Paige E Condit, Ryan Lindstrom, Shayla N Gunderson, Matthew W Harer
{"title":"Evaluation of kidney oxygenation compared to intestinal oxygenation and feeding timing in preterm neonates.","authors":"Paige E Condit, Ryan Lindstrom, Shayla N Gunderson, Matthew W Harer","doi":"10.1038/s41372-026-02915-3","DOIUrl":"10.1038/s41372-026-02915-3","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stefanie Riddle, Isabella Zaniletti, Karna Murthy, Alaina Pyle, Ellen Bendel-Stenzel, Elizabeth Jacobson, Theresa Grover, Heidi Karpen, Franscesca Miquel-Verges, Sadie Williams, Jennifer Rumpel, Michael A Padula
{"title":"Predicting risk of infection in infants with gastroschisis.","authors":"Stefanie Riddle, Isabella Zaniletti, Karna Murthy, Alaina Pyle, Ellen Bendel-Stenzel, Elizabeth Jacobson, Theresa Grover, Heidi Karpen, Franscesca Miquel-Verges, Sadie Williams, Jennifer Rumpel, Michael A Padula","doi":"10.1038/s41372-026-02880-x","DOIUrl":"https://doi.org/10.1038/s41372-026-02880-x","url":null,"abstract":"<p><strong>Objective: </strong>Identify clinical predictors of bloodstream (BSI) and urinary tract infections (UTI) in infants with gastroschisis.</p><p><strong>Study design: </strong>Retrospective analysis of infants with gastroschisis admitted to 47 neonatal intensive care units (NICUs) contributing to the Children's Hospitals Neonatal Database (CHND) from 2010-23. Outcomes were occurrence of BSI or UTI before discharge. Generalized linear models with generalized estimating equation (GEE) to account for hospitals as clusters utilized to identify factors independently related to the outcomes.</p><p><strong>Result: </strong>Of 3987 eligible infants, rates of early BSI (within 3 days of birth) were 0.4%, any BSI 7.6% and UTI 3.5%. Median age of infection was 32 days for BSI and 39 days for UTI. Bowel atresia, silo/staged closure, patch closure, and additional anomalies were independently associated with these infections.</p><p><strong>Conclusion: </strong>We identified clinical predictors of BSI and UTI, which should facilitate limitation of antibiotic use in low risk patients.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robert Seán Ballantine, Ellen Campbell, Ovidiu Croitoru, Emma Jackson, Eric John Lyne, Ciara McGoldrick, Sally Mary Murphy, Karina Oganezova, Tavishi Shukla, Sujjanv S Yogesan, James Trayer, Philip Stewart, Stephen Carroll, Aoife Branagan, Edna Roche, Saira Tabassum, Thomas Abrahamsson, Nicholas Embleton, Janet Berrington, Saenz de Pipaon Miguel, Daphne H Klerk, Lise Aunsholt, Jennifer Canvasser, Erin Pryor, Camilia Cami R Martin, Judith Meehan, Eleanor J Molloy
{"title":"Definitions of neonatal Necrotizing Enterocolitis (NEC) in randomised controlled trials: a systematic review.","authors":"Robert Seán Ballantine, Ellen Campbell, Ovidiu Croitoru, Emma Jackson, Eric John Lyne, Ciara McGoldrick, Sally Mary Murphy, Karina Oganezova, Tavishi Shukla, Sujjanv S Yogesan, James Trayer, Philip Stewart, Stephen Carroll, Aoife Branagan, Edna Roche, Saira Tabassum, Thomas Abrahamsson, Nicholas Embleton, Janet Berrington, Saenz de Pipaon Miguel, Daphne H Klerk, Lise Aunsholt, Jennifer Canvasser, Erin Pryor, Camilia Cami R Martin, Judith Meehan, Eleanor J Molloy","doi":"10.1038/s41372-026-02905-5","DOIUrl":"https://doi.org/10.1038/s41372-026-02905-5","url":null,"abstract":"<p><strong>Background and aims: </strong>Necrotizing Enterocolitis (NEC) is a significant cause of morbidity and mortality for preterm neonates. Although Bell's criteria are frequently used to assess stage of NEC, it was not a definition and, since its inception in 1978 and with the survival of neonates at earlier gestations, there is a requirement for an updated NEC definition. This systematic review aimed to evaluate the use of criteria for the diagnosis and staging of NEC in randomised clinical control trials.</p><p><strong>Methods: </strong>This systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A search was conducted through PubMed to identify Randomised Control Trials (RCTs) in the last twenty years that used NEC in the study title and in either the primary outcome or the inclusion criterion.</p><p><strong>Results: </strong>The initial search identified fifty-six RCTs. Thirty-six RCTs were included for full-text analysis. Thirty-three trials used Bell's criteria or Modified Bell's criteria to define NEC and three RCTs unique, author-created definitions.</p><p><strong>Conclusions: </strong>There is consistent use of Bell's and Modified Bell's criteria of necrotizing enterocolitis in RCTs. However, international consensus on further modifications of the definition will greatly contribute to both research and clinical practice relating to NEC, in allowing greater consistency in the staging of NEC, and therefore optimal management.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multimodal non-pharmacological pain relief during adhesive tape removal in preterm infants: a randomized controlled trial.","authors":"Negarin Akbari, Canan Genc, Duygu Gozen, Ayhan Tastekin, Emine Irem Abayli","doi":"10.1038/s41372-026-02911-7","DOIUrl":"https://doi.org/10.1038/s41372-026-02911-7","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effectiveness of facilitated tucking combined with oral breast milk (FT + OBM) and kangaroo care combined with oral breast milk (KC + OBM) in reducing pain during adhesive tape removal in preterm infants.</p><p><strong>Study design: </strong>This randomized controlled trial was conducted in a Level III NICU in Turkey and registered with the clinical trial ID NCT06455631. A total of 119 preterm infants (gestational age 30⁰⁄⁷-36⁶⁄⁷ weeks) were randomly assigned to FT + OBM, KC + OBM, or control groups. Pain was assessed using the Premature Infant Pain Profile-Revised, and physiological parameters were analyzed using generalized estimating equations.</p><p><strong>Results: </strong>Both intervention groups showed significantly lower pain scores than the control group (p < 0.001). Pain increased during tape removal but decreased afterward in both intervention groups. No significant difference was found between intervention groups.</p><p><strong>Conclusion: </strong>Two intervention groups are effective non-pharmacological strategies for reducing pain in preterm infants.</p><p><strong>Clinical trial registration: </strong>The trial has been registered on www.</p><p><strong>Clinicaltrials: </strong>gov , ID: NCT06455631. Patient enrollment began prior to trial registration due to the urgency of recruiting within a limited study period and delays in obtaining access to the trial registration platform. The study protocol was finalized and approved by the institutional ethics committee before enrollment, and no changes were made to the protocol after registration.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara B DeMauro, Meghan Burkhardt, Melissa Hanin, Audrey N Miller, Melissa House, Meaghan Ransom, Tara DuPont, Megan Lagoski, Audrey Wood, Brianna K Brei, Kristin Brinker, Chelsea Wittwer, Kathleen Gibbs
{"title":"Neurodevelopmental therapy in NICUs that care for infants with bronchopulmonary dysplasia.","authors":"Sara B DeMauro, Meghan Burkhardt, Melissa Hanin, Audrey N Miller, Melissa House, Meaghan Ransom, Tara DuPont, Megan Lagoski, Audrey Wood, Brianna K Brei, Kristin Brinker, Chelsea Wittwer, Kathleen Gibbs","doi":"10.1038/s41372-026-02891-8","DOIUrl":"https://doi.org/10.1038/s41372-026-02891-8","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chloe Salzmann, Evan Cross, Ke Yan, Jian Zhang, Erwin Cabacungan, T Hang Nghiem-Rao, Alicia Sprecher
{"title":"Timing and intensity of lactation support influences NICU discharge on maternal milk.","authors":"Chloe Salzmann, Evan Cross, Ke Yan, Jian Zhang, Erwin Cabacungan, T Hang Nghiem-Rao, Alicia Sprecher","doi":"10.1038/s41372-026-02895-4","DOIUrl":"https://doi.org/10.1038/s41372-026-02895-4","url":null,"abstract":"<p><strong>Objective: </strong>We evaluated maternal and infant factors that influence lactation success within the neonatal intensive care unit (NICU) and the impact of early lactation support.</p><p><strong>Study design: </strong>This was a retrospective cohort study of 862 maternal-infant dyads admitted to the NICU. The relationship between lactation support and discharge home receiving mother's own milk (MOM) was examined after adjusting for demographic and clinical covariates.</p><p><strong>Result: </strong>Infants whose mothers who had 4-6 lactation visits within the first 14 days were 8.93 times more likely to discharge receiving MOM (95% CI 4.86-16.40, P < 0.05). Infants born to mothers who were White, primiparous, partnered, had private insurance, and with higher household incomes were more likely to discharge receiving MOM.</p><p><strong>Conclusion: </strong>At least 4 lactation visits within the first 2 weeks postpartum increases the likelihood of infant discharge on MOM. Hospitals should provide adequate access to lactation consultants to account for this need.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stephanie K Kukora, Megan Mariner Gray, Courtney Kiser McLean, Jeanne Krick
{"title":"Threats to neonatologists' professional identity formation: ethical implications of condensing neonatal-perinatal fellowship.","authors":"Stephanie K Kukora, Megan Mariner Gray, Courtney Kiser McLean, Jeanne Krick","doi":"10.1038/s41372-026-02899-0","DOIUrl":"https://doi.org/10.1038/s41372-026-02899-0","url":null,"abstract":"<p><p>The American Board of Pediatrics (ABP) recently announced a plan to alter pediatric subspecialty fellowship training. Such changes pose meaningful ethical and psychosocial consequences on neonatologists' professional identity formation (PIF), including how they develop moral reasoning, experience and manage distress, and sustain themselves in practice. In the current state, the ABP's plan poses serious ethical risks, compromising not only the foundations of future neonatologists but also our mission to provide high-quality patient care. In this paper, we argue that it is an ethical imperative for Neonatal-Perinatal Medicine (NPM) fellowship programs to nurture the evolving professional identities of learners who will guide future innovation and progress in the field, while providing education that supports ethical, family-centered, high-quality clinical care for the most vulnerable patients.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kristina Thompsen, Malika Shah, Joseph Fishbein, Lindsay Skibley, Leena B Mithal
{"title":"Evaluation of reflexive, hearing-targeted congenital cytomegalovirus screening at a high-volume center.","authors":"Kristina Thompsen, Malika Shah, Joseph Fishbein, Lindsay Skibley, Leena B Mithal","doi":"10.1038/s41372-026-02897-2","DOIUrl":"https://doi.org/10.1038/s41372-026-02897-2","url":null,"abstract":"<p><strong>Objective: </strong>Examine congenital cytomegalovirus (cCMV) testing practices before and after implementation of a hospital-wide, reflexive, hearing-targeted screening policy.</p><p><strong>Study design: </strong>91079 infants from 2016 to 2023 were included retrospectively from our center. cCMV testing and diagnosis rates were compared before and after implementation of a provider cCMV education program and policy automating a nursing order for cCMV test prior to discharge after referred NBHS.</p><p><strong>Result: </strong>The proportion of infants with referred NBHS who underwent cCMV screening increased after implementation compared to prior (7.7% versus 95.2%, p < 0.0001). cCMV screening for non-hearing-related cCMV indicators also increased (0.9% versus 3.3%, p < 0.0001). cCMV positivity rates prior to and after implementation were 0.015% and 0.036%, respectively (p = 0.053).</p><p><strong>Conclusion: </strong>This hospital-wide, reflexive, hearing-targeted screening policy was associated with significantly improved cCMV screening rates and may enhance early cCMV detection, supporting standardized hospital-specific protocols and education to implement state mandates.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alyssa R Thomas, Lene Nymo Trulsen, Philip T Levy, Noorjahan Ali, Anup C Katheria
{"title":"Video-based assessment of delivery room stabilization in newborns with prenatally diagnosed congenital heart disease: Insights beyond chart review.","authors":"Alyssa R Thomas, Lene Nymo Trulsen, Philip T Levy, Noorjahan Ali, Anup C Katheria","doi":"10.1038/s41372-026-02890-9","DOIUrl":"https://doi.org/10.1038/s41372-026-02890-9","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah N Kunz, Marinka Zitnik, Daniel Helkey, Sheila Razdan, Jeffrey B Gould, Jochen Profit, John A F Zupancic
{"title":"Differential transport patterns by race and ethnicity in very low birth weight infants.","authors":"Sarah N Kunz, Marinka Zitnik, Daniel Helkey, Sheila Razdan, Jeffrey B Gould, Jochen Profit, John A F Zupancic","doi":"10.1038/s41372-026-02896-3","DOIUrl":"https://doi.org/10.1038/s41372-026-02896-3","url":null,"abstract":"<p><strong>Objective: </strong>To determine how the likelihood of acute transfer for very low birth weight (VLBW) infants differs by race and ethnicity.</p><p><strong>Study design: </strong>This retrospective cohort study used data for VLBW, preterm ( < 37 weeks) infants <28 days old born between 2012 and 2018 to identify acute inter-hospital transports between hospitals in California. We calculated the odds ratio for acute transport for each race and ethnicity (non-Hispanic White, non-Hispanic Black, Asian American/Native Hawaiian/Pacific Islander [AANHPI], and Hispanic), controlling for network, hospital, maternal sociodemographic, and infant clinical characteristics.</p><p><strong>Result: </strong>AANHPI infants were significantly less likely to be transported compared to non-Hispanic White infants (OR 0.85; p = 0.01) after risk adjustment. Hospital-level factors (e.g. NICU level) were most significantly associated with transfer likelihood.</p><p><strong>Conclusion: </strong>The likelihood of acute transfer for VLBW infants differs by race and ethnicity, which may reflect underlying inequities and implicit biases in the system of care.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}