Journal of Perinatology最新文献_第5页

Medical treatment of gastroesophageal reflux in the neonatal intensive care unit: current practice.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-22 DOI: 10.1038/s41372-025-02238-9

Chelsea Lockyear, Ashley Stark, Henry P Foote, Anthony Agyeman, Manar Bouleqcha, Noam Cohen, Clare Matusevich, Ansley Pantsari, Shuyan Wang, Sharla Rent, William Malcolm, Veeral N Tolia, Rachel G Greenberg, Samia Aleem

{"title":"Medical treatment of gastroesophageal reflux in the neonatal intensive care unit: current practice.","authors":"Chelsea Lockyear, Ashley Stark, Henry P Foote, Anthony Agyeman, Manar Bouleqcha, Noam Cohen, Clare Matusevich, Ansley Pantsari, Shuyan Wang, Sharla Rent, William Malcolm, Veeral N Tolia, Rachel G Greenberg, Samia Aleem","doi":"10.1038/s41372-025-02238-9","DOIUrl":"10.1038/s41372-025-02238-9","url":null,"abstract":"Objective: To determine current prescribing practice of acid-suppressive therapy in preterm infants admitted to the neonatal intensive care unit (NICU).Study design: Cohort study of infants 22 to 27 weeks gestation discharged from Pediatrix Medical Group NICUs between 2015 and 2020.Results: Of 13,735 infants meeting inclusion criteria, 11% were exposed to acid-suppressive therapy during hospitalization, with 3% of those treated on the day of discharge. Exposed infants had lower birthweights (BW) (p < 0.001). 42% of infants exposed to acid-suppressive therapy received a gastroesophageal reflux disease (GERD) diagnosis (p < 0.001). Median (25th-75th percentile) duration of use was 7 (4-14) days. Use decreased overall during the 5-year period (p < 0.001).Conclusion: Acid-suppressive therapies are used commonly in preterm infants and receipt is higher in infants with lower BWs. Use has significantly decreased over time and appears to be targeted, with many infants treated for one-week courses and without a diagnosis of GERD.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Golden hour management of infants with congenital diaphragmatic hernia: 15 year experience at a high-volume center.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-21 DOI: 10.1038/s41372-025-02226-z

K Taylor Wild, Holly L Hedrick, Natalie E Rintoul, Anne M Ades, Juliana S Gebb, Leny Mathew, Tom Reynolds, Anna Bostwick, Elizabeth Eppley, Sabrina Flohr, N Scott Adzick, Elizabeth E Foglia

{"title":"Golden hour management of infants with congenital diaphragmatic hernia: 15 year experience at a high-volume center.","authors":"K Taylor Wild, Holly L Hedrick, Natalie E Rintoul, Anne M Ades, Juliana S Gebb, Leny Mathew, Tom Reynolds, Anna Bostwick, Elizabeth Eppley, Sabrina Flohr, N Scott Adzick, Elizabeth E Foglia","doi":"10.1038/s41372-025-02226-z","DOIUrl":"https://doi.org/10.1038/s41372-025-02226-z","url":null,"abstract":"Objective: To review the evolution of golden hour management and outcomes for infants with congenital diaphragmatic hernia (CDH).Study design: Retrospective single center cohort study of infants with CDH born 2008-2023 at a quaternary children's hospital. Infants were grouped into 3 epochs: 2008-2013, 2014-2018, and 2019-2023. Outcome measures included extracorporeal membrane oxygenation therapy and survival.Result: There were 454 infants, including 106 (2008-2013), 156 (2014-2018), and 192 (2019-2023). Despite increased disease severity, survival improved over time, from 71% (2008-2013) to 82% (2014-2018) and 83% (2019-2023), p = 0.02 for trend, with no difference in ECMO utilization.Conclusion: Management of infants with CDH continues to evolve with ongoing experience at our high-volume center. Despite increasing severity of illness, survival outcomes have improved over time. In the absence of clinical trial data, observational data should be evaluated rigorously to inform care in a data-driven manner.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal pulmonary function tests in infants born to COVID-19 positive mothers. COVID-19 阳性母亲所生婴儿的新生儿肺功能测试。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-21 DOI: 10.1038/s41372-025-02237-w

Katy Ruch, Kelvin D MacDonald, Kseniya Parkhotyuk, Diane Schilling, Mathew Olson, Shawn Mehess, Kristin Milner, Cindy T McEvoy

{"title":"Neonatal pulmonary function tests in infants born to COVID-19 positive mothers.","authors":"Katy Ruch, Kelvin D MacDonald, Kseniya Parkhotyuk, Diane Schilling, Mathew Olson, Shawn Mehess, Kristin Milner, Cindy T McEvoy","doi":"10.1038/s41372-025-02237-w","DOIUrl":"https://doi.org/10.1038/s41372-025-02237-w","url":null,"abstract":"Objective: To compare pulmonary function tests (PFTs), specifically passive respiratory system compliance (Crs), in infants of mothers positive for COVID-19 during pregnancy compared to PFTs from a historical cohort of matched, healthy reference infants.Study design: A prospective cohort study of infants born to COVID-19 positive mothers. Crs was measured with the single breath occlusion technique. Historical cohort data was obtained from a pre-COVID-19 data repository. Respiratory questionnaires were done at 1-year postnatal age.Results: Twenty-four PFTs in the COVID-19 cohort were compared with PFTs from 24 reference subjects. Infants of the COVID-19 positive mothers had a Crs of 3.57 ml/cmH2O versus 3.76 mL/cmH2O in the reference group (p > 0.05). The remaining PFT outcomes were comparable between groups. The COVID-19 infants reported more allergic symptoms and conditions through 1-year.Conclusion: We found no difference in Crs in infants of mothers with COVID-19 during pregnancy compared to a historical pre-COVID reference cohort.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

General movement assessments in neonates born with congenital gastrointestinal anomalies: a single site, retrospective study.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-21 DOI: 10.1038/s41372-024-02207-8

Lisa Soumekh, Samantha Bell, Sandra L Espinosa, Tristan Grogan, Kalpashri Kesavan, Kara L Calkins

{"title":"General movement assessments in neonates born with congenital gastrointestinal anomalies: a single site, retrospective study.","authors":"Lisa Soumekh, Samantha Bell, Sandra L Espinosa, Tristan Grogan, Kalpashri Kesavan, Kara L Calkins","doi":"10.1038/s41372-024-02207-8","DOIUrl":"https://doi.org/10.1038/s41372-024-02207-8","url":null,"abstract":"Objective: We aimed to characterize general movements in neonates with congenital gastrointestinal anomalies and to compare them to general movements in extremely low birth weight (ELBW) infants.Study design: This was a retrospective, single-site study. Subjects were divided into two groups: those with gastrointestinal (GI) anomalies and ELBW infants (birth weight <1 kg). The primary outcome was general movement assessments.Result: Ninety-six infants were included (n = 51, GI group and n = 45, ELBW group). The rates of abnormal general movements between the groups were comparable (writhing movements: 61% vs. 59%, p = 0.89; fidgety movements: 20% vs. 36%, p = 0.13). Writhing movements were different (100% poor repertoire, 0% cramped synchronous in the GI group vs. 50% poor repertoire and 50% cramped synchronous in the ELBW group, p < 0.001).Conclusion: Infants with gastrointestinal anomalies are at risk for abnormal general movements. Abnormal fidgety general movements may be an early biomarker for future motor deficits.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experiences of communication in the neonatal intensive care unit for mothers with a preferred language other than English.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-20 DOI: 10.1038/s41372-025-02229-w

Nikita S Kalluri, Rachel E Witt, Zuzanna Kubicka, Margaret G Parker, Erika G Cordova-Ramos

{"title":"Experiences of communication in the neonatal intensive care unit for mothers with a preferred language other than English.","authors":"Nikita S Kalluri, Rachel E Witt, Zuzanna Kubicka, Margaret G Parker, Erika G Cordova-Ramos","doi":"10.1038/s41372-025-02229-w","DOIUrl":"https://doi.org/10.1038/s41372-025-02229-w","url":null,"abstract":"Objective: To understand the experiences of mothers with a preferred language other than English (PLOE) in communicating with staff and engaging in the care of their hospitalized infant.Design: We qualitatively analyzed a previously collected and a prospective dataset comprised of transcripts of 36 interviews with Spanish-, Haitian Creole-, and Brazilian Portuguese-speaking mothers of preterm infants from 3 NICUs. We applied the constant comparative method to develop codes and themes, which were inductively structured using the socio-ecological framework.Results: We identified themes across socio-ecological levels: Individual (unaddressed language barriers, varied maternal empowerment, and justification of suboptimal interpreter use); Interpersonal (family-staff language concordance facilitating engagement, positive impact of non-interpreted informal interactions, and differential treatment based on maternal language status); Institutional (system-level interpretation barriers and varied interpreter service quality).Conclusion: Mothers with PLOE face multilevel communication and engagement barriers in the NICU; we discuss potential interventions to improve equity in these areas.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving Commitment to Family-Centered Care in the NICU: A Multicenter Collaborative Quality Improvement Project.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-20 DOI: 10.1038/s41372-025-02232-1

Malathi Balasundaram, Henry C Lee, Laura C Hedli, Kerri Z Machut, Dharshi Sivakumar, Morgan Kowalski, Rafael Mendelsohn, Keira Sorrells, Colby Day

{"title":"Improving Commitment to Family-Centered Care in the NICU: A Multicenter Collaborative Quality Improvement Project.","authors":"Malathi Balasundaram, Henry C Lee, Laura C Hedli, Kerri Z Machut, Dharshi Sivakumar, Morgan Kowalski, Rafael Mendelsohn, Keira Sorrells, Colby Day","doi":"10.1038/s41372-025-02232-1","DOIUrl":"10.1038/s41372-025-02232-1","url":null,"abstract":"Objective: Despite evidence demonstrating the positive impact of family-centered care (FCC) in the neonatal intensive care unit (NICU), FCC is not standard of care. This multi-center, quality improvement initiative aimed to increase the percentage of NICUs with FCC committees and Family Partnership Councils (FPCs).Study design: Participating NICUs were divided into small groups for collaborative mentoring. A key driver diagram and Pareto charts evaluated barriers to FCC and directed interventions. The primary outcome measure was development of an FCC committee and/or FPC. Process measures were views of bi-monthly educational webinars, evaluated using Statistical Process Control charts.Result: Across 22 NICUs, the percentage with FCC committees and FPCs increased from 18% to 59% and 18% to 45%, respectively. Average webinar views increased from 28 to 182 views/webinar with clear signal on XmR chart.Conclusion: A collaborative mentoring model and focused education achieved the goal of increasing NICU FCC committees and FPCs.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A budget impact analysis of an expanded criteria for pasteurized donor human milk use: a single center experience.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-20 DOI: 10.1038/s41372-025-02235-y

Dylan G Choi, Kelly Stapleton, Cynthia L Gong, Stephanie A Schnell, Leah Yieh

引用次数: 0

Correction: Human milk derived fortifiers are associated with glucose, phosphorus, and calcium derangements.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-20 DOI: 10.1038/s41372-025-02241-0

Danielle Ackley, Jiamin Yin, Carl D'Angio, Jeffrey Meyers, Bridget Young

引用次数: 0

The effect of using dexmedetomidine versus morphine as sedation on long-term neurodevelopmental outcomes of encephalopathic neonates undergoing therapeutic hypothermia.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-20 DOI: 10.1038/s41372-025-02227-y

Tatiana A Nuzum, Sadaf H Kazmi, Elena V Wachtel

{"title":"The effect of using dexmedetomidine versus morphine as sedation on long-term neurodevelopmental outcomes of encephalopathic neonates undergoing therapeutic hypothermia.","authors":"Tatiana A Nuzum, Sadaf H Kazmi, Elena V Wachtel","doi":"10.1038/s41372-025-02227-y","DOIUrl":"https://doi.org/10.1038/s41372-025-02227-y","url":null,"abstract":"Objective: To compare neurodevelopmental outcomes using Bayley Scales of Infant Development (BSID), between encephalopathic neonates undergoing therapeutic hypothermia (TH), sedated with either continuous dexmedetomidine or intermittent morphine.Study design: Retrospective, observational cohort study including encephalopathic neonates born between 2014 - 2022 that underwent TH at two Regional Perinatal Centres, and completed neurodevelopmental follow-up assessments.Results: There were no significant differences in demographics or short-term neurologic outcomes between morphine (n = 30) and dexmedetomidine (n = 32) groups. At 12 months, median motor composite scores (104 vs 98.5, p = 0.02) and median fine motor scaled scores (SS) (11 vs 10, p = 0.01) were significantly higher in the dexmedetomidine group. Median expressive language SS were slightly higher in the morphine group (11 v 10, p = 0.05). BSID scores at 18-24 months were similar.Conclusion: This study supports the use of dexmedetomidine as first-line sedation agent during TH, given comparable 18-24 month neurodevelopmental outcomes.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perfluoroalkyl substances and preterm birth.

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-02-18 DOI: 10.1038/s41372-025-02231-2

Anne M Mullin, Abby F Fleisch, Clementina Mesaros, Rachel Ledyard, Michele R Hacker, Heather H Burris

引用次数: 0