右美托咪定对新生儿镇静、疼痛、呼吸状态和心血管系统的影响。

IF 2.4 3区 医学 Q2 OBSTETRICS & GYNECOLOGY
Marjorie M Makoni, Ivonne Sierra-Strum, Adrianne R Bischoff, Jamie L Miller, Lise DeShea, William Howard Beasley, Edgardo Szyld
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引用次数: 0

摘要

目的:描述右美托咪定对新生儿镇静、疼痛、呼吸状态和血流动力学的影响。方法:回顾性研究206例IV级NICU(2016-2021)持续输注右美托咪定的婴儿。术前记录疼痛/镇静评分、血压、血管加压和肌力评分(VIS)以及伴随使用的镇静/镇痛药物(CSA),每3-4 h记录一次,持续24 h。结果:中位PMA:32周。结论:右美托咪定联合CSA增加了具有独特心肌结构和功能的早产儿心血管不稳定,因此易感程度更高。临床试验注册(如有):无(不适用)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dexmedetomidine's effect on neonatal sedation, pain, respiratory status and cardiovascular system.

Objective: To describe the effects of dexmedetomidine on sedation, pain, respiratory status, and hemodynamics in neonates.

Methods: A retrospective study of 206 infants in a level IV NICU (2016-2021) receiving continuous dexmedetomidine infusion. Pain/sedation scores, BP, vasopressor and inotrope score (VIS), and concomitant sedatives/analgesics (CSA) were recorded before and every 3-4 h for 24 h.

Results: Median PMA:32 weeks. Hypotension occurred in 26%, primarily in infants <32weeks PMA, correlating with higher VIS and CSA. CSA use significantly predicted vasopressors/inotrope use.

Conclusion: Dexmedetomidine, with CSA, increases cardiovascular instability in preterm infants who have unique myocardial structure and function and therefore higher vulnerability.

Clinical trial registration (if any): None (not applicable).

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来源期刊
Journal of Perinatology
Journal of Perinatology 医学-妇产科学
CiteScore
5.40
自引率
6.90%
发文量
284
审稿时长
3-8 weeks
期刊介绍: The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.
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