纯母乳喂养的早产儿发生坏死性小肠结肠炎的相关危险因素：一项单中心病例对照研究

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-08-30 DOI:10.1038/s41372-025-02401-2

Haider Ailumerab, Jamie L Miller, Lise DeShea, William Howard Beasley, Hala Chaaban, Erynn M Bergner

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引用次数: 0

摘要

目的：确定接受纯母乳饮食（EHMD）的早产儿发生坏死性小肠结肠炎（NEC）的早期新生儿和母体危险因素。研究设计：在接受EHMD治疗时发生NEC≥2期的早产儿与在相同饮食条件下未发生NEC的对照组进行比较。选择NEC的预测因子，根据文献或单预测因子模型的显著性进行多预测因子logistic回归分析。结果：共纳入27例，对照组98例，平均GA = 27周。各组在基线特征上无显著差异。产妇尿路感染、分娩前产妇中性粒细胞与淋巴细胞比值和第一周血管加压素的使用显著预测NEC。结论：尽管使用EHMD， NEC仍然值得关注，强调其多因素性质。结果强调了母体炎症和早期新生儿血流动力学不稳定在NEC发展中的潜在作用。研究结果可以为未来旨在识别高危婴儿的研究提供信息。

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Risk factors associated with the development of necrotizing enterocolitis in preterm infants on an exclusive human milk diet: a single-center case-control study.

Objective: Identify early neonatal and maternal risk factors for development of necrotizing enterocolitis (NEC) in preterm infants receiving an exclusive human milk diet (EHMD).

Study design: Preterm infants who developed NEC stage ≥2 while receiving an EHMD were compared to matched controls who did not develop NEC on the same diet. Predictors of NEC were selected for multiple-predictor logistic regression analysis based on literature or significance in single-predictor models.

Results: A total of 27 cases and 98 controls (mean GA = 27 weeks) were included. Groups did not differ significantly on baseline characteristics. Maternal urinary tract infection, maternal neutrophil-to-lymphocyte ratio before delivery, and vasopressor use during the first week significantly predicted NEC.

Conclusion: Despite the use of EHMD, NEC remains a concern, underlining its multifactorial nature. Results highlight the potential role of maternal inflammation and early neonatal hemodynamic instability in NEC development. Findings could inform future research aimed at identifying high-risk infants.

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.