{"title":"Oral dextrose gel for hypoglycemia in a well-baby nursery: a baby-friendly initiative","authors":"Mansi Batra, Kelechi Ikeri, Michelle Blake, Genevieve Mantell, Ramachandra Bhat, Michael Zayek","doi":"10.1038/s41372-024-02114-y","DOIUrl":"https://doi.org/10.1038/s41372-024-02114-y","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Objectives</h3><p>To assess the impact of oral dextrose gel (ODG) treatment on NICU admission rates for hypoglycemic infants in a well-baby nursery.</p><h3 data-test=\"abstract-sub-heading\">Study design</h3><p>We retrospectively compared newborn infants at risk for hypoglycemia born during the intervention period (<i>n</i> = 3775) with historical controls (<i>n</i> = 655). We also compared the rates of the primary outcome (NICU admission) and secondary outcomes (exclusive breastfeeding and hospital costs) between the two periods.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Following the implementation of ODG supplementation, the NICU admissions rates dropped from 4% to 2%, <i>p</i> < 0.05, for at-risk infants and from 15% to 7%, <i>p</i> < 0.05, for hypoglycemic infants in the baseline and intervention periods, respectively, with an adjusted OR (95% CI) of 0.39 (0.24–0.64), <i>p</i> < 0.001. Additionally, the ODG protocol sustained rates of exclusive breastfeeding in contrast to the institutional protocol.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The adoption of an ODG protocol fosters a more nurturing and baby-friendly environment through reduced NICU transfers, support for exclusive breastfeeding, and decreased hospital costs.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"5 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cecile L. Yama, Rachel G. Greenberg, Erika Johnson, Deesha D. Mago-Shah
{"title":"Social needs and healthcare utilization in NICU graduates","authors":"Cecile L. Yama, Rachel G. Greenberg, Erika Johnson, Deesha D. Mago-Shah","doi":"10.1038/s41372-024-02105-z","DOIUrl":"10.1038/s41372-024-02105-z","url":null,"abstract":"Unplanned healthcare utilization after neonatal intensive care unit (NICU) discharge challenges families and healthcare systems. The impact of social needs on post-NICU healthcare utilization is underexplored. Our objective was to identify social needs among NICU graduates and examine associations between social needs and post-NICU healthcare utilization. A prospective cohort design was used to screen for social needs and track healthcare utilization among 112 NICU graduates attending a NICU follow-up clinic (2021–2022). Associations between social needs and healthcare utilization were analyzed using non-parametric statistical tests. Of 112 patients screened, 20 (18%) had some social need. Infants with social needs experienced statistically significant higher rates of hospitalizations, overall encounters, and missed appointments. Social needs are associated with increased unplanned healthcare utilization and missed appointments. Addressing these needs during NICU follow-up may improve preventative care attendance and reduce unplanned healthcare use, leading to better outcomes for vulnerable infants and cost-savings for healthcare systems.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"44 12","pages":"1732-1737"},"PeriodicalIF":2.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41372-024-02105-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Margot Hillyer, Michael Fundora, Feifei Williams, Michelle Gleason, Mary Lukacs, Shannon Hamrick, Jonathan Meisel, Shanelle Clarke, Natalie Korcinsky-Tillman, Nikhil Chanani
{"title":"Standardizing the diagnosis of necrotizing enterocolitis in infants with congenital heart disease","authors":"Margot Hillyer, Michael Fundora, Feifei Williams, Michelle Gleason, Mary Lukacs, Shannon Hamrick, Jonathan Meisel, Shanelle Clarke, Natalie Korcinsky-Tillman, Nikhil Chanani","doi":"10.1038/s41372-024-02112-0","DOIUrl":"https://doi.org/10.1038/s41372-024-02112-0","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Objective</h3><p>This quality improvement initiative aimed to standardize the diagnosis of necrotizing enterocolitis (NEC) in infants with congenital heart disease (CHD).</p><h3 data-test=\"abstract-sub-heading\">Study design</h3><p>A multidisciplinary team developed clinical practice guidelines for the diagnosis and treatment of NEC within the Cardiac Intensive Care Unit (CICU). The diagnosis rate of NEC per 100 at-risk admissions was the primary outcome measure. NEC order set usage was employed as a process measure, and the balancing measures monitored were CICU length of stay (LOS) and mortality.</p><h3 data-test=\"abstract-sub-heading\">Result</h3><p>After guideline development and implementation, the diagnosis rate of NEC decreased from 3% to 1%, sustained over three years. The EMR order set enabled guideline integration into daily workflow. No change was noted in CICU LOS or mortality.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Guideline implementation standardized the diagnosis of NEC in infants with CHD. Establishing a standardized definition and subsequent treatment regimen has enabled us to provide more consistent and appropriate care.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"47 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adriana Hoffman, Sriram Satyavolu, Danah Muhanna, Sindhoosha Malay, Thomas Raffay, Anne Windau, Eric M. Ransom, Devashis Mukherjee
{"title":"Predictors of mortality and severe illness from Escherichia coli sepsis in neonates","authors":"Adriana Hoffman, Sriram Satyavolu, Danah Muhanna, Sindhoosha Malay, Thomas Raffay, Anne Windau, Eric M. Ransom, Devashis Mukherjee","doi":"10.1038/s41372-024-02117-9","DOIUrl":"10.1038/s41372-024-02117-9","url":null,"abstract":"Neonatal Escherichia coli (E. coli) sepsis is increasing. There is limited data on the factors contributing to increased mortality and severity of illness in neonatal E. coli sepsis. A retrospective review of neonates (<30 days) admitted to a Level IV NICU in the United States from 2008 to 2022 diagnosed with E. coli bloodstream or cerebrospinal fluid infection was conducted. Primary outcome was defined as mortality from or severe illness during E. coli infection (defined as a need for inotropic support or metabolic acidosis). E. coli neonatal sepsis rate increased from 2008 to 2022 (average of 1.12 per 1000 live births). The primary outcome, which occurred in 57.4% of cases, was independently associated with prematurity, neutropenia, and thrombocytopenia. Ampicillin resistance was not associated with the primary outcome. GA, neutropenia, and thrombocytopenia but not ampicillin resistance, are associated with mortality or severe illness from E. coli sepsis.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"44 12","pages":"1-6"},"PeriodicalIF":2.4,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41372-024-02117-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emily Abdelmessih, Purnahamsi V. Desai, Joanna Tracy, John Papadopoulos, Ferras Bashqoy
{"title":"Don’t wait, vaccinate: evaluation of routine vaccination administration and reactogenicity in preterm infants","authors":"Emily Abdelmessih, Purnahamsi V. Desai, Joanna Tracy, John Papadopoulos, Ferras Bashqoy","doi":"10.1038/s41372-024-02111-1","DOIUrl":"https://doi.org/10.1038/s41372-024-02111-1","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Objective</h3><p>To evaluate the incidence of cardiorespiratory events in preterm infants when administering the 2-month vaccine series all at once compared to spreading vaccines over multiple days.</p><h3 data-test=\"abstract-sub-heading\">Study design</h3><p>This single-center, retrospective cohort study from 2019–2022 included preterm neonates receiving 2-month vaccinations. The primary outcome was incidence of cardiorespiratory events from time of initial vaccine administration up to 48 h after final administration. Univariate analysis was performed to identify predictors of primary outcome.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>There were 127 patients (pre-practice change <i>n</i>1 = 52, post-practice change <i>n</i>2 = 75) included with no difference in the number of cardiorespiratory events between groups. Predictors of severe event included younger gestational age, smaller birth weight, shorter birth length, and greater cardiorespiratory events at baseline. Vaccine schedule interruptions occur more often when administration is spread over multiple days.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Administration of 2-month vaccinations all at once was not associated with increased cardiorespiratory events and prevents interruptions to vaccine schedule.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"73 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Numra Abdul Aleem, John T. Wren Jr., J. Lauren Ruoss, Amy H. Stanford, Rachael M. Hyland, Brady Thomas, Regan E. Giesinger, Patrick J. McNamara
{"title":"Neonatal cardiac POCUS—a survey of academic neonatal centers in the United States","authors":"Numra Abdul Aleem, John T. Wren Jr., J. Lauren Ruoss, Amy H. Stanford, Rachael M. Hyland, Brady Thomas, Regan E. Giesinger, Patrick J. McNamara","doi":"10.1038/s41372-024-02108-w","DOIUrl":"10.1038/s41372-024-02108-w","url":null,"abstract":"To investigate the current state of clinical practice and training regarding the use of cardiac point of care ultrasound (cPOCUS) in neonatal intensive care units. An online survey was disseminated through the Association of Academic Directors of Neonatology to appraise clinical usage, infrastructure, and training for cPOCUS. A single response per center was obtained. Overall survey response rate was 51% (48/94). Of respondents [40/48 (83%)] who reported having a POCUS program, 19/40 (47%) reported performing cPOCUS. In 74% of centers, <10 cPOCUS studies are performed monthly. Only 16% (3/19) of centers had standardized imaging protocols. The most common indication for cPOCUS was central line evaluation. Only 9 (19%) programs reported cPOCUS training, of whom 4 had a formalized process of ongoing competency assessment. Although use of cPOCUS is increasing, program infrastructure and governance, training, and evaluation vary markedly between institutions and are missing in many. There is an urgent need to develop consensus standards regarding clinical practice and training.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"44 10","pages":"1509-1514"},"PeriodicalIF":2.4,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caitlin Hoffman, Melissa Harris, Krishna Acharya, Margaret Malnory, Susan Cohen, Joanne Lagatta
{"title":"Impact of systematic screening for social determinants of health in a level IV neonatal intensive care unit.","authors":"Caitlin Hoffman, Melissa Harris, Krishna Acharya, Margaret Malnory, Susan Cohen, Joanne Lagatta","doi":"10.1038/s41372-024-02096-x","DOIUrl":"10.1038/s41372-024-02096-x","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether screening for social determinants of health (SDoH) in a level IV neonatal intensive care unit (NICU) could uncover additional family needs.</p><p><strong>Methods: </strong>Secondary analysis of a prospective study in a level IV NICU. Participants filled out the Protocol for Responding to and Assessing Patients' Assets, Risks and Experiences (PRAPARE) tool, which includes economic, housing, transportation, and safety questions. Questionnaires were completed via secure tablet; the research team notified social workers of reported needs. Illness and demographic characteristics were compared between families who did and did not report resource needs. Manual chart review assessed subsequent response to reported SDoH needs.</p><p><strong>Results: </strong>Of 319 respondents, 61(19%) reported resource needs. Of 61 families, 88% received repeat social work encounters to re-assess for resources; 59% received new resource referrals.</p><p><strong>Conclusions: </strong>Systematic SDoH screening can identify needs throughout the NICU stay, even among families already connected to social work support.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vera Balog, Gabor Liszkay, Lajos Lantos, Agnes Jermendy, Gusztav Belteki
{"title":"High-frequency oscillatory ventilation with or without volume guarantee during neonatal transport.","authors":"Vera Balog, Gabor Liszkay, Lajos Lantos, Agnes Jermendy, Gusztav Belteki","doi":"10.1038/s41372-024-02109-9","DOIUrl":"https://doi.org/10.1038/s41372-024-02109-9","url":null,"abstract":"<p><strong>Objectives: </strong>To analyse deviation of ventilator parameters from their set targets during high-frequency oscillatory ventilation (HFOV) with or without volume guarantee (VG) and compare the two modes during emergency neonatal transport.</p><p><strong>Study design: </strong>Retrospective observational study using the fabian™ HFOi ventilator.</p><p><strong>Results: </strong>Median deviation of mean airway pressure from the set value was <1 cmH<sub>2</sub>O. During HFOV the pressure amplitude differed from the set value by <1 cmH<sub>2</sub>O. During HFOV-VG median deviation of the oscillation volume (VThf) from the targeted value was -0.07 mL/kg, but in some cases VThf was by >0.38 mL/kg below target. Setting maximum allowed amplitude 10 cmH<sub>2</sub>O above the usually required amplitude improved maintenance of VThf. HFOV and HFOV-VG parameters were similar, except the lower amplitude during HFOV without VG. VThf <2.5 mL/kg avoided hypercapnia in most cases.</p><p><strong>Conclusions: </strong>HFOV and HFOV-VG maintain ventilator parameters close to their targets and are promising modalities during neonatal transport.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kathryn Joanna Paul, Senbagam Virudachalam, Diana Montoya-Williams, Scott Lorch
{"title":"Associations between food insecurity and low birth weight severity in a national sample.","authors":"Kathryn Joanna Paul, Senbagam Virudachalam, Diana Montoya-Williams, Scott Lorch","doi":"10.1038/s41372-024-02094-z","DOIUrl":"https://doi.org/10.1038/s41372-024-02094-z","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}