Maria S. Rueda, Lamia Soghier, Joseph Campos, Burak Bahar, James E. Bost, Jiaxiang Gai, Rana F. Hamdy
{"title":"Blood volume collected for cultures in infants with suspected neonatal sepsis","authors":"Maria S. Rueda, Lamia Soghier, Joseph Campos, Burak Bahar, James E. Bost, Jiaxiang Gai, Rana F. Hamdy","doi":"10.1038/s41372-024-02120-0","DOIUrl":"10.1038/s41372-024-02120-0","url":null,"abstract":"To evaluate blood culture sample volumes, identify factors linked to insufficient samples, and compare volumes among neonates treated for culture-negative-sepsis, sepsis-rule-outs, and bloodstream infections (BSI). Observational cohort of blood cultures collected during NICU stay. Association of age, weight, gender, source, and collection time with lower-than-recommended volumes was determined by logistic regression. Blood culture inocula of patients with culture-negative-sepsis, sepsis rule-out, and BSI were compared using ANOVA. 742 blood cultures were obtained from 292 neonates. Median inoculum was 1 mL (IQR:0.6–1.4), and 259 bottles (35%) had inocula <0.9 mL. Night shift sample collection was associated with lower-than-recommended volumes (p = 0.006). No difference in sample volumes was observed between culture-negative-sepsis, sepsis-rule-outs, and BSI (p = 0.5). Median NICU blood culture volumes align with recommendations. Night shift collections correlate with lower volumes. Sample volumes don’t differ in patients with culture-negative-sepsis, BSI, and sepsis-rule-out, and should not be a justification for longer duration of antibiotics.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"44 12","pages":"1800-1804"},"PeriodicalIF":2.4,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lucy E. Geraghty, Greta Gambacorta, Colm P. F. O’Donnell
{"title":"Direct laryngoscopy versus indirect videolaryngoscopy for intubating newborn manikins: a randomised crossover study","authors":"Lucy E. Geraghty, Greta Gambacorta, Colm P. F. O’Donnell","doi":"10.1038/s41372-024-02110-2","DOIUrl":"10.1038/s41372-024-02110-2","url":null,"abstract":"Gaining and maintaining proficiency at endotracheal intubation is challenging. Recent clinical trials suggest videolaryngoscopy is beneficial for teaching inexperienced clinicians to intubate newborn infants, but may take longer compared to standard laryngoscopy. Preferences for devices among clinicians are unclear. Simulation studies using manikins have shown that use of videolaryngoscopes (VLs) likely improves intubation outcomes, at least in the short term. This study is the first to compare different VLs and SL as they are designed in clinicians with varying levels of experience in term and preterm manikins. This setup more closely mimics real-life clinical practice in comparison to trials exclusively of novices or using VL devices to intubate directly. Our study is relevant to members of the perinatal and neonatal clinical care team and related to using technology to improve neonatal outcomes. It is of particular importance in the current environment of reduced opportunities to learn and maintain neonatal intubation skills due to changes in neonatal practice and clinical care.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"45 1","pages":"146-148"},"PeriodicalIF":2.4,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sclerothrapy of giant lymphatic malformation in neonates.","authors":"Fan Hu, Fan Ma, Xiaoliang Liu, Jiayun Yu","doi":"10.1038/s41372-024-02113-z","DOIUrl":"https://doi.org/10.1038/s41372-024-02113-z","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the sclerotherapy of giant (≥8 mm) lymphatic malformations in neonates and discuss effective treatment.</p><p><strong>Methods: </strong>This was a single-center retrospective study. Twelve patients received bleomycin (BLM) (six patients) or BLM combined with polidocanol (POL) (eight patients). The safety and effects of BLM and BLM + POL were analyzed using a t-test for categorical data and likelihood ratios or Fisher's exact test for continuous data. Factors resulting in an increased number of treatment sessions were studied.</p><p><strong>Results: </strong>Treatment began 2-5 days after birth. The patients in the BLM group underwent more treatment sessions. Gestational age, lesion size and type, total response, and complications showed no significant differences between groups. Larger and mixed-ype lesions required more treatment sessions.</p><p><strong>Conclusions: </strong>Both BLM group and BLM + POL group appear relatively safe and effective in neonates with giant lymphatic malformations. The combination of the two agents reduced the number of procedures and general anesthesia required.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Richie Dalai, Sarita Mohapatra, Thirumurthy Velpandian, Jeeva Sankar, Anu Thukral, Ankit Verma, Minu Bajpai, R. Dhinakaran, Mohammad Tousifullah, Ramesh Agarwal
{"title":"Antiseptic efficacy and plasma chlorhexidine levels following two different methods of application of 1% aqueous chlorhexidine gluconate for skin disinfection in preterm newborns: a randomized controlled trial","authors":"Richie Dalai, Sarita Mohapatra, Thirumurthy Velpandian, Jeeva Sankar, Anu Thukral, Ankit Verma, Minu Bajpai, R. Dhinakaran, Mohammad Tousifullah, Ramesh Agarwal","doi":"10.1038/s41372-024-02122-y","DOIUrl":"10.1038/s41372-024-02122-y","url":null,"abstract":"Many neonatal units have started using Chlorhexidine gluconate for neonatal skin antisepsis. However, there is in-vitro evidence of inhibition of neurite growth. The current study aimed to compare two methods of its local application, for the extent of systemic absorption and antiseptic efficacy. Parallel group, blinded, randomised trial, at a Level III, neonatal intensive care unit. Between December 2020 to July 2022, neonates from 28 to 34 weeks gestation, were randomized to local skin antisepsis by either- (a) 1% aqueous chlorhexidine (CHG aq) followed by cleansing off the residual agent with sterile water swab (Cleansing group) or (b)1% CHG aq followed by air drying (No cleansing group). The outcome measures were the proportion of post antisepsis skin swabs with no/insignificant growth, and the plasma chlorhexidine levels. Of the total of 457 enrollments (Cleansing: n = 230; No Cleansing: n = 227), 216 (93.91%) in “Cleansing” vs. 221 (97.36%) in “No cleansing” (risk difference -3.45%, 95% CI –7.2 to 0.28%; p = 0.072) had no/insignificant growth post-antisepsis. The lower bound of the confidence interval crossed the pre-specified non-inferiority limit of 5%. The median (IQR) plasma chlorhexidine levels were not significantly different between the two groups (7.9 (5.6, 17.9)) ng/mL in Cleansing vs. 6.5 (4.6, 17.7) in No cleansing groups (p = 0.437). Cleansing with sterile water after application of chlorhexidine in preterm neonates was not shown to be non-inferior compared to no cleansing, for skin antisepsis efficacy. Systemic absorption occurred to a similar extent despite cleansing off the residual agent. CTRI/2020/10/028719","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"45 1","pages":"128-133"},"PeriodicalIF":2.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kayla R Holloway, Joshua Radack, Alejandra Barreto, Barbara H Chaiyachati, Diana Montoya-Williams, Angela M Ellison, Heather H Burris
{"title":"The \"Other\" race category on birth certificates and its impact on analyses of preterm birth inequity.","authors":"Kayla R Holloway, Joshua Radack, Alejandra Barreto, Barbara H Chaiyachati, Diana Montoya-Williams, Angela M Ellison, Heather H Burris","doi":"10.1038/s41372-024-02123-x","DOIUrl":"10.1038/s41372-024-02123-x","url":null,"abstract":"<p><strong>Objective: </strong>Not all individuals self-identify with race categories on birth certificates, selecting \"Other\" and writing in identities. Our hypothesis was that curating write-in responses in the \"Other\" race category would contribute to understanding preterm birth inequities.</p><p><strong>Methods: </strong>We analyzed Pennsylvania birth certificates (2006-2014). Two independent coders reviewed each write-in response among those who selected \"Other\" race. We compared preterm birth rates across subpopulations within \"Other\" race category using a Monte Carlo simulated Chi-square test.</p><p><strong>Results: </strong>Among 1,196,125 singleton births, 72,891 (6.1%) exclusively selected \"Other\" race; Hispanic more often than non-Hispanic individuals (54.5% vs 0.7%), p < 0.0001). Only 545 (0.8%) of Hispanic individuals wrote in responses aligned with preestablished race categories compared to 2,601 (33.2%) of non-Hispanic individuals. Preterm birth rates varied significantly across identities within the \"Other\" group (P < 0.001).</p><p><strong>Conclusion: </strong>Utilizing combinations of self-identified race, ethnicity, and continental origin may facilitate public health efforts focused on birth outcome equity.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Madeleine C. Ing, Olivia A. Keane, Ashwini Lakshmanan, Eugene Kim, Henry C. Lee, Lorraine I. Kelley-Quon
{"title":"Opioid equipotency conversions for hospitalized infants: a systematic review","authors":"Madeleine C. Ing, Olivia A. Keane, Ashwini Lakshmanan, Eugene Kim, Henry C. Lee, Lorraine I. Kelley-Quon","doi":"10.1038/s41372-024-02121-z","DOIUrl":"10.1038/s41372-024-02121-z","url":null,"abstract":"Hospitalized infants commonly receive opioids to reduce pain and minimize distress during invasive procedures. However, infant neurodevelopment is significantly impacted by cumulative and prolonged opioid exposures. While opioid conversion has been studied extensively in adults, no standardized equipotency opioid conversions exist for hospitalized infants and opioid stewardship efforts are inconsistent. We performed a systematic review to identify opioid dosing conversions commonly used in hospitalized infants <1 year of age, finding fourteen articles which documented or cited a calculation of cumulative opioid exposure. Morphine milligram equivalents (MME) conversion factors varied widely, with nine studies citing conversion equivalent equations commonly used in adults. Efforts to expand safe opioid stewardship to hospitalized infants will require evidence-based consensus for opioid equipotency dose conversions which acknowledge the unique physiology of infants.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"44 12","pages":"1709-1718"},"PeriodicalIF":2.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41372-024-02121-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ariadne Malamitsi-Puchner, Despina D Briana, Josef Neu
{"title":"The conundrum of intestinal injury in preterm infants receiving mother's own milk.","authors":"Ariadne Malamitsi-Puchner, Despina D Briana, Josef Neu","doi":"10.1038/s41372-024-02125-9","DOIUrl":"https://doi.org/10.1038/s41372-024-02125-9","url":null,"abstract":"<p><p>\"Necrotizing enterocolitis\" (\"NEC\") is a heterogeneous group of intestinal injuries experienced primarily in preterm infants. Risk factors include among others preterm gut microbiome alterations. Maternal milk (MM), or otherwise parent milk, is protective for the developing intestine due to its constituents, which include bioactive antimicrobials, immunomodulatory molecules, human milk oligosaccharides (HMOs), secretory immunoglobulin A (sIgA), and microorganisms. However, some preterm infants receiving exclusively mother's own milk (MOM) develop intestinal injuries. Studies showed predisposition to increased risk for \"NEC\", when a decreased MM HMO, disialyllacto-N-tetraose, is combined with an altered infant's gut microbiome. The intestine may also become more prone to injury with a greater amount of bacteria not bound to IgA. Variations in MM composition may alter the offspring gut microbiome, depriving protection. The different \"NEC\" entities should be considered to play a role as to why, in many studies, MOM does not provide absolute protection against preterm intestinal injury.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew R. Michienzi, Ashly Dunham, Andrew J. Groberg
{"title":"Is fluid balance in the first 14 days of life associated with respiratory outcomes in extremely premature neonates? EBM Lesson: Covariate selection in an observation study","authors":"Matthew R. Michienzi, Ashly Dunham, Andrew J. Groberg","doi":"10.1038/s41372-024-02119-7","DOIUrl":"https://doi.org/10.1038/s41372-024-02119-7","url":null,"abstract":"<p>Starr MC, Griffin R, Gist KM, Segar JL, Raina R, et al. Association of Fluid Balance with Short- and Long-term Respiratory Outcomes in Extremely Premature Neonates: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open 2022 [1].</p><p>Secondary Analysis of a Randomized Clinical Trial.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"121 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neurological outcomes and associated perinatal factors in infants born between 22 and 25 weeks with active care","authors":"Yu Ariyoshi, Takayuki Iriyama, Takahiro Seyama, Seisuke Sayama, Eriko Yano, Kensuke Suzuki, Taiki Samejima, Mari Ichinose, Masatake Toshimitsu, Kenbun Sone, Atsushi Ito, Yoshihiko Shitara, Keiichi Kumasawa, Kohei Kashima, Satsuki Kakiuchi, Yasushi Hirota, Naoto Takahashi, Yutaka Osuga","doi":"10.1038/s41372-024-02093-0","DOIUrl":"https://doi.org/10.1038/s41372-024-02093-0","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Objectives</h3><p>To elucidate the outcomes of periviable infants receiving active care (AC) and explore perinatal factors associated with neurodevelopmental outcomes.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This is a single-center retrospective study on infants born at 22–25 weeks of gestation, all of whom received AC. A developmental quotient (DQ) ≥ 85 at corrected 18 months was judged as normal.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Fifty-seven infants were included in the study. The survival rates at discharge were 83%, 86%, 93%, and 93% at 22, 23, 24, and 25 gestational weeks, respectively. The overall percentage of normal DQ was 26/47 (55%). Acidemia in the arterial blood gas measured within 6 h after birth was identified as a factor significantly associated with subnormal DQ.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Not only high survival rates, but also favorable neurodevelopmental outcomes may be achieved by AC in periviable infants. Moreover, impaired neurodevelopmental outcomes may be associated with early postnatal acidemia following initial resuscitation.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"50 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexander E. Graf, Simon Bellido, Chellapriya Vythinathan, Jigar Govind, Lawrence Fordjour, Sydney C. Butts, Ann Woodhouse Plum
{"title":"Reporting nasal pressure injuries in neonates receiving non-invasive ventilation: a scoping review","authors":"Alexander E. Graf, Simon Bellido, Chellapriya Vythinathan, Jigar Govind, Lawrence Fordjour, Sydney C. Butts, Ann Woodhouse Plum","doi":"10.1038/s41372-024-02006-1","DOIUrl":"10.1038/s41372-024-02006-1","url":null,"abstract":"Although neonates receiving Non-Invasive Ventilation (NIV) for respiratory support are at risk for nasal pressure injuries, efforts to standardize reporting are limited. A scoping review was conducted to identify the reporting systems used for describing these injuries. PubMed, Embase, and Web of Science were queried for papers reporting nasal injury with NIV usage in neonates. The primary outcome was reporting system usage. 705 titles and abstracts were screened. 40 papers met inclusion criteria. Most studies were Randomized Clinical Trials (37.5%) or cohort studies (37.5%). Most commonly, nasal injuries were reported using a unique, descriptive scale developed by the authors (10 studies, 25%). The Fischer et al 2010 scale, a three-stage reporting system, was used in 8 studies (20%). While 15 studies (38.0%) reported on specific anatomic subsite injury, only 2 studies (5.0%) employed endoscopy for assessment. Wide heterogeneity in pressure injury reporting secondary to NIV exists across specialties, institutions, and literature.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"44 12","pages":"1-9"},"PeriodicalIF":2.4,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}