Proteinuria in preterm neonates: influence of fetal growth restriction.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-04-19 DOI:10.1038/s41372-025-02306-0

Arvind Sehgal, Criona Levins, Emma Yeomans, Zhong Lu, David Metz

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引用次数: 0

Abstract

Objective: To compare proteinuria in preterm neonates with fetal growth restriction-small for gestational age (FGR-SGA) against equally preterm but appropriate for gestational age (AGA) neonates.

Study design: Prospective, observational cohort study.

Results: Eighteen FGR-SGA neonates were compared with 18 AGA neonates (gestation; 29 ± 1 vs 29 ± 2 weeks, P = 0.8). Urine total protein (median [interquartile range]) in FGR-SGA was higher 370 [323, 573] vs 255 [193, 453] mg/L in AGA, P = 0.017 at first assessment (week one) and 565 [445, 743] vs 225 [135, 458] mg/L, P = 0.0011 at second assessment (week four). Urine protein creatinine ratio was 393 [250, 445] in FGR-SGA vs 227 [163, 367] mg/mmol in AGA, P = 0.029 at first assessment and 444 [368, 699] vs 240 [199, 411] mg/mmol, P = 0.0014 at second assessment. Mean blood pressure was higher in FGR-SGA group & directly correlated with proteinuria.

Conclusions: Increased proteinuria in FGR-SGA suggests reduced nephron endowment and hyper-filtration.

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早产儿蛋白尿：胎儿生长受限的影响。

目的：比较胎儿生长受限-小于胎龄（FGR-SGA）早产儿和同等早产但适宜胎龄（AGA）新生儿的蛋白尿。研究设计：前瞻性、观察性队列研究。结果：18例FGR-SGA新生儿与18例AGA新生儿(妊娠期；29±1 vs 29±2周，P = 0.8)。FGR-SGA组尿总蛋白（中位数[四分位数范围]）高于AGA组，分别为370[323,573]和255 [193,453]mg/L，第一次评估（第1周）和565[445,743]和225 [135,458]mg/L，第二次评估（第4周），P = 0.0011。FGR-SGA组尿蛋白肌酐比值为393 [250,445]vs 227 [163, 367] mg/mmol，第一次评估时P = 0.029；第二次评估时为444 [368,699]vs 240 [199, 411] mg/mmol, P = 0.0014。FGR-SGA组平均血压升高，与蛋白尿直接相关。结论：FGR-SGA中蛋白尿增加提示肾元供体减少和超滤过。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.