Faris N Al Gharaibeh, Star Liu, James L Wynn, Khyzer B Aziz
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引用次数: 0
Abstract
Objective: Assess the utility of the neonatal sequential organ failure assessment score (nSOFA) for evaluation-specific mortality discrimination in all late-onset infection (LOI) evaluations.
Methods: Retrospective Cohort of all neonates who had an LOI evaluation from 2012 to 2023 in a single level IV Academic NICU in Florida, USA. The primary outcome was LOI-evaluation-specific mortality.
Results: 1481 neonates had 2916 LOI evaluations with a 3.8% mortality rate. The AUROC for the nSOFA score at evaluation was 0.76 (95% CI 0.71-0.81) and improved to 0.82 (95% CI 0.78-0.87) six hours after. nSOFA ≥2 within 6 h of the start of the LOI was 87% sensitive and 66% specific, with a 99% NPV for mortality, p < 0.0001.
Conclusions: The nSOFA score had good to excellent mortality discrimination at the LOI evaluation level. These results solidify the utility of the nSOFA score as the foundation for a consensus definition of neonatal sepsis.
目的：评估新生儿顺序器官衰竭评估评分（nSOFA）在所有迟发性感染（LOI）评估中评估特异性死亡率歧视的效用。方法：回顾性队列研究2012 - 2023年在美国佛罗里达州一家IV级学术NICU接受LOI评估的所有新生儿。主要终点是loi评估特异性死亡率。结果：1481例新生儿LOI评价2916次，死亡率3.8%。评估时nSOFA评分的AUROC为0.76 (95% CI 0.71-0.81)， 6小时后提高至0.82 （95% CI 0.78-0.87）。在LOI开始后6小时内，nSOFA≥2的敏感性为87%，特异性为66%，死亡率NPV为99%。结论：nSOFA评分在LOI评价水平上具有良好至优异的死亡率区分能力。这些结果巩固了nSOFA评分作为新生儿败血症共识定义的基础。
期刊介绍：
The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development.
The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.
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