Journal of PerinatologyPub Date : 2025-05-01Epub Date: 2025-01-16DOI: 10.1038/s41372-024-02202-z
Seham Elmrayed, Susan Dai, Abhay Lodha, Manoj Kumar, Tanis R Fenton
{"title":"Preterm growth assessment: the latest findings on age correction.","authors":"Seham Elmrayed, Susan Dai, Abhay Lodha, Manoj Kumar, Tanis R Fenton","doi":"10.1038/s41372-024-02202-z","DOIUrl":"10.1038/s41372-024-02202-z","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of age correction up to 36 months of age for growth assessments of extremely preterm (<28 weeks) and very preterm (28 to <32 weeks) infants.</p><p><strong>Study design: </strong>This longitudinal analysis used data from the Preterm Infant Multicenter Growth Study (2001-2014).</p><p><strong>Results: </strong>1,416 children were included (Median gestational age = 27 weeks). Chronological age-based weight, height, and head circumference z-scores were consistently lower than those based on corrected age for all ages (0, 4, 8, 21 and 36 months) by up to -5.2 (95% confidence interval -5.4, -5.1) z-scores for length at term. Using chronological age, higher proportions of children were misclassified as having suboptimal growth (up to 72.9% misdiagnosed as stunted and 89.8% misdiagnosed as underweight at term).</p><p><strong>Conclusion: </strong>For extremely and very preterm children, age correction is required for all growth measures through 36 months of corrected age.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"607-615"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of PerinatologyPub Date : 2025-05-01Epub Date: 2024-07-17DOI: 10.1038/s41372-024-02054-7
Christie J Bruno, Megan M Gray, Kristen T Leeman, Kerri Z Machut, Renate Savich, Cynthia Crabtree, Lindsay C Johnston
{"title":"A survey on transparency in clinical work expectations and compensation factors: empowering women in neonatology.","authors":"Christie J Bruno, Megan M Gray, Kristen T Leeman, Kerri Z Machut, Renate Savich, Cynthia Crabtree, Lindsay C Johnston","doi":"10.1038/s41372-024-02054-7","DOIUrl":"10.1038/s41372-024-02054-7","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"676-677"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141633814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danielle Ackley, Jiamin Yin, Carl D'Angio, Jeffrey Meyers, Bridget Young
{"title":"Correction: Human milk derived fortifiers are associated with glucose, phosphorus, and calcium derangements.","authors":"Danielle Ackley, Jiamin Yin, Carl D'Angio, Jeffrey Meyers, Bridget Young","doi":"10.1038/s41372-025-02241-0","DOIUrl":"10.1038/s41372-025-02241-0","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"698"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of PerinatologyPub Date : 2025-05-01Epub Date: 2025-02-22DOI: 10.1038/s41372-025-02238-9
Chelsea Lockyear, Ashley Stark, Henry P Foote, Anthony Agyeman, Manar Bouleqcha, Noam Cohen, Clare Matusevich, Ansley Pantsari, Shuyan Wang, Sharla Rent, William Malcolm, Veeral N Tolia, Rachel G Greenberg, Samia Aleem
{"title":"Medical treatment of gastroesophageal reflux in the neonatal intensive care unit: current practice.","authors":"Chelsea Lockyear, Ashley Stark, Henry P Foote, Anthony Agyeman, Manar Bouleqcha, Noam Cohen, Clare Matusevich, Ansley Pantsari, Shuyan Wang, Sharla Rent, William Malcolm, Veeral N Tolia, Rachel G Greenberg, Samia Aleem","doi":"10.1038/s41372-025-02238-9","DOIUrl":"10.1038/s41372-025-02238-9","url":null,"abstract":"<p><strong>Objective: </strong>To determine current prescribing practice of acid-suppressive therapy in preterm infants admitted to the neonatal intensive care unit (NICU).</p><p><strong>Study design: </strong>Cohort study of infants 22 to 27 weeks gestation discharged from Pediatrix Medical Group NICUs between 2015 and 2020.</p><p><strong>Results: </strong>Of 13,735 infants meeting inclusion criteria, 11% were exposed to acid-suppressive therapy during hospitalization, with 3% of those treated on the day of discharge. Exposed infants had lower birthweights (BW) (p < 0.001). 42% of infants exposed to acid-suppressive therapy received a gastroesophageal reflux disease (GERD) diagnosis (p < 0.001). Median (25th-75th percentile) duration of use was 7 (4-14) days. Use decreased overall during the 5-year period (p < 0.001).</p><p><strong>Conclusion: </strong>Acid-suppressive therapies are used commonly in preterm infants and receipt is higher in infants with lower BWs. Use has significantly decreased over time and appears to be targeted, with many infants treated for one-week courses and without a diagnosis of GERD.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"616-621"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of PerinatologyPub Date : 2025-05-01Epub Date: 2025-03-22DOI: 10.1038/s41372-025-02269-2
Caroline G Borden, Veronika Shabanova, Sarah N Taylor, Catherine O Buck
{"title":"Alterations in infant adipokine concentrations in the first postnatal week with exposure to diabetes in pregnancy.","authors":"Caroline G Borden, Veronika Shabanova, Sarah N Taylor, Catherine O Buck","doi":"10.1038/s41372-025-02269-2","DOIUrl":"10.1038/s41372-025-02269-2","url":null,"abstract":"<p><strong>Objective: </strong>Characterize changes in neonatal energy metabolism hormones in first postnatal week.</p><p><strong>Study design: </strong>Concentrations of leptin, adiponectin, insulin, resistin, and ghrelin were measured in cord and infant blood collected in the first postnatal week in a prospective cohort of term and preterm infants. Change over time in each hormone was modeled using linear mixed effects regression.</p><p><strong>Result: </strong>Among 106 infants, 65 (61%) were preterm and 44 (42%) were exposed to diabetes (DM) in pregnancy. DM group had higher leptin [between group difference β 2.5 (95%CI: 1.72-3.70)] and resistin [β 1.5 (95%CI:1.14, 1.92)] and lower ghrelin [β 0.49] [95%CI: (0.32-0.76)] versus non-DM group. Preterm infants had lower adiponectin [β 0.80 (95%CI: 0.67-0.96)] versus term group. Insulin varied by DM and prematurity (interaction-term p value < 0.05).</p><p><strong>Conclusion: </strong>In this cohort, hormone concentrations varied by DM and prematurity. Early alterations in energy metabolism hormones may reflect changes in developmental programming which persist in the early postnatal period.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"622-627"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of PerinatologyPub Date : 2025-05-01Epub Date: 2024-12-04DOI: 10.1038/s41372-024-02184-y
Tiana T Nguyen, Roberta Pineda, Stacey Reynolds, Elizabeth E Rogers, Audrey E Kane
{"title":"Medical and sociodemographic characteristics related to feeding therapy referral and service provision for preterm infants in the neonatal intensive care unit.","authors":"Tiana T Nguyen, Roberta Pineda, Stacey Reynolds, Elizabeth E Rogers, Audrey E Kane","doi":"10.1038/s41372-024-02184-y","DOIUrl":"10.1038/s41372-024-02184-y","url":null,"abstract":"<p><strong>Objective: </strong>To determine the scope of feeding therapy for preterm infants in the NICU and medical and sociodemographic factors related to feeding therapy referral and service provision.</p><p><strong>Study design: </strong>Retrospective study of infants born <37 weeks gestation in a level IV NICU between January 2017 and December 2019.</p><p><strong>Result: </strong>Among 547 infants, 27% of infants received a feeding therapy referral, and 74% of those referrals were problem-based referrals. Feeding therapy referrals were more likely among infants with lower gestational ages and birthweights (both p < 0.001). In addition, infants with greater medical complexity, who required oxygen at 36 weeks, who had a history of mechanical ventilation, and who had a higher postmenstrual age at discharge were more likely to be referred to feeding therapy (all p < 0.001).</p><p><strong>Conclusion: </strong>While medical factors relate to feeding therapy referrals, there are other complex person and system factors that determine feeding therapy referral and service provision.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"657-664"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of PerinatologyPub Date : 2025-05-01Epub Date: 2025-03-26DOI: 10.1038/s41372-025-02277-2
Mark A Underwood
{"title":"The fifty billion dollar question: does formula cause necrotizing enterocolitis?","authors":"Mark A Underwood","doi":"10.1038/s41372-025-02277-2","DOIUrl":"10.1038/s41372-025-02277-2","url":null,"abstract":"<p><p>The question of whether preterm infant formulas cause necrotizing enterocolitis (NEC) is the subject of multiple lawsuits and has daily relevance in the care of preterm infants. Research supporting the hypothesis that toxic components in infant formula cause NEC is limited to preclinical data while data from human infants are lacking. Human milk should be the first choice for most preterm infants, however, preterm infant formula is at times a critical alternative. It is the absence of human milk that increases NEC risk rather than toxic components in preterm infant formula.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"565-571"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of PerinatologyPub Date : 2025-05-01Epub Date: 2025-04-25DOI: 10.1038/s41372-025-02310-4
Ryan M McAdams, Renate Savich, Patrick J McNamara, Lily Lou, Jens C Eickhoff, Satyan Lakshminrusimha
{"title":"Impact of shift durations on sleep, fatigue, and wellness among neonatologists: a cross-sectional survey analysis.","authors":"Ryan M McAdams, Renate Savich, Patrick J McNamara, Lily Lou, Jens C Eickhoff, Satyan Lakshminrusimha","doi":"10.1038/s41372-025-02310-4","DOIUrl":"10.1038/s41372-025-02310-4","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effects of shift durations on sleep, fatigue, and wellness among U.S. neonatologists in diverse settings.</p><p><strong>Methods: </strong>A cross-sectional survey of U.S. neonatologists yielded 810 responses from 4400 recipients. Statistical analyses included ANOVA, logistic regression, and cluster analysis.</p><p><strong>Results: </strong>Younger neonatologists (<35 years) reported the highest fatigue levels, with females more affected than males (p = 0.0185). Male neonatologists were less likely than females (OR 0.55, p = 0.0013), and those in university settings more likely than non-university settings (OR 1.43, p = 0.0389), to report adverse effects of shifts >16 h. Cluster analysis identified three fatigue patterns, with the most severe among younger neonatologists working shifts >16 h.</p><p><strong>Conclusion: </strong>Long shifts (>16 h) negatively affect neonatologists' wellness, particularly younger and female clinicians. With most neonatal-perinatal medicine fellows being female, policies addressing shift duration are needed.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"589-594"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of PerinatologyPub Date : 2025-05-01Epub Date: 2024-12-09DOI: 10.1038/s41372-024-02198-6
Mar Romero-Lopez, Mamta Naik, Lindsay F Holzapfel, Jon E Tyson, Claudia Pedroza, Kaashif A Ahmad, Matthew A Rysavy, Waldemar A Carlo, Yuxin Zhang, Covi Tibe, Ariel A Salas
{"title":"Enteral nutritional practices in extremely preterm infants: a survey of U.S. NICUs.","authors":"Mar Romero-Lopez, Mamta Naik, Lindsay F Holzapfel, Jon E Tyson, Claudia Pedroza, Kaashif A Ahmad, Matthew A Rysavy, Waldemar A Carlo, Yuxin Zhang, Covi Tibe, Ariel A Salas","doi":"10.1038/s41372-024-02198-6","DOIUrl":"10.1038/s41372-024-02198-6","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"670-672"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of PerinatologyPub Date : 2025-05-01Epub Date: 2024-11-20DOI: 10.1038/s41372-024-02182-0
Yingying Zheng, Jennifer Fowler, Chance Rector, Dmitry Tumin, Maja Herco
{"title":"Impact of changing donor human milk feeding guideline for extremely preterm infants on the use of infant formula and cost of donor human milk purchase.","authors":"Yingying Zheng, Jennifer Fowler, Chance Rector, Dmitry Tumin, Maja Herco","doi":"10.1038/s41372-024-02182-0","DOIUrl":"10.1038/s41372-024-02182-0","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"665-667"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}