{"title":"Real-time ultrasound to assess the umbilical catheter position in neonates: a randomized, controlled trial.","authors":"Lalita Ponin, Chayatat Ruangkit, Nichanan Ruangwattanapaisarn, Pracha Nuntnarumit","doi":"10.1038/s41372-024-02128-6","DOIUrl":"https://doi.org/10.1038/s41372-024-02128-6","url":null,"abstract":"<p><strong>Objective: </strong>To compare real-time ultrasound (RT-US) use as an adjunct tool to verify umbilical catheter placement versus standard care without ultrasound.</p><p><strong>Study design: </strong>Neonates requiring umbilical venous catheter (UVC) and umbilical artery catheter (UAC) placement were randomized into the standard formula (No-US) and the RT-US groups. X-rays were used to confirm the catheter position.</p><p><strong>Result: </strong>Fifty and forty-nine neonates were in the RT-US and No-US groups, respectively. RT- US showed a significantly higher rate of initial X-ray-confirmed proper catheter position than No-US (p < 0.001). The rates of proper positions of UVCs and UACs were significantly higher in the RT-US group than in the No-US group (both p < 0.001). Neonates in the RT-US group required fewer catheter adjustments and subsequent X-rays than those in the No-US group.</p><p><strong>Conclusion: </strong>RT-US enhances the accuracy of UVC and UAC placement, reduces catheter adjustments, and the number of X-rays required.</p><p><strong>Trial registration: </strong>TCTR20190622001.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alessia Gallipoli, Sharon Unger, Amr El Shahed, Chun-Po Steve Fan, Marisa Signorile, Diane Wilson, Rebecca Hoban
{"title":"Outcomes after intranasal human milk therapy in preterm infants with intraventricular hemorrhage.","authors":"Alessia Gallipoli, Sharon Unger, Amr El Shahed, Chun-Po Steve Fan, Marisa Signorile, Diane Wilson, Rebecca Hoban","doi":"10.1038/s41372-024-02147-3","DOIUrl":"https://doi.org/10.1038/s41372-024-02147-3","url":null,"abstract":"<p><strong>Objective: </strong>Intraventricular hemorrhage (IVH) is a common cause of brain injury in preterm infants. Fresh human milk (HM) contains stem cells (SCs) that could potentially be delivered via intranasal HM (IHM). In this IHM pilot study, we describe outcomes.</p><p><strong>Study design: </strong>Infants <33 weeks gestation with IVH were given IHM until maximum 28 days of age. Short-term neurologic outcomes and follow-up testing were compared to historic HM-fed infants. Longitudinal outcomes were plotted using linear mixed models. Weighted G-computation quantified treatment effects. Propensity score models calculated inverse probability weights for IVH grade, gestational age, and sex.</p><p><strong>Result: </strong>37 infants (35.1% grade 3-4 IVH) were compared to 191 historic controls (17.8% grade 3-4 IVH). Post-hemorrhagic ventricular dilatation was common (25.7% IHM patients). Most weighted outcomes, although not significant, favored IHM at 4-12 and 18 months corrected age.</p><p><strong>Conclusion: </strong>This phase 1 study suggests powered trials of IHM for brain injury are needed. CLINICAL TRIAL REGISTRY NAME: clinicaltrials.gov identifier NCT04225286.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of QI collaboratives in neonatology.","authors":"Roopali Bapat, Stephen Pearlman","doi":"10.1038/s41372-024-02124-w","DOIUrl":"https://doi.org/10.1038/s41372-024-02124-w","url":null,"abstract":"<p><p>Quality improvement collaboratives (QICs) use their collective experiences from participating centers to accelerate the translation of evidence into practice, resulting in reduced variation and improved clinical outcomes. There are several regional, national, and international QICs in neonatology. In this review, we discuss the framework and evaluate national QICs primarily based in US and share the contributions of selected studies. We found that the QICs in neonatology play a significant role in identification of target topics, developing best practices, improving provider knowledge, building QI capacity, and improving outcomes. The key strengths of QICs are that they produce more generalizable learnings, involve a larger patient population which enhances statistical analysis, and offer resources to smaller institutions. Limitations include institutions contributing unequally to the overall results, difficulty in interpreting results when multiple improvement strategies are applied simultaneously, and the possible lack of academic recognition for individual center leadership.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mar Romero-Lopez, Samantha Su, Rafael Bravo, Danielle R Rios, Tina Oak Findley, Covi Anne Tibe, Patrick J McNamara
{"title":"The effect of furosemide on extremely premature infants treated with nonsteroidal anti-inflammatory drugs for persistent patent ductus arteriosus.","authors":"Mar Romero-Lopez, Samantha Su, Rafael Bravo, Danielle R Rios, Tina Oak Findley, Covi Anne Tibe, Patrick J McNamara","doi":"10.1038/s41372-024-02148-2","DOIUrl":"https://doi.org/10.1038/s41372-024-02148-2","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Maternity care practices supportive of breastfeeding in U.S. advanced neonatal care units, United States, 2022","authors":"E. Anstey, A. Noiman, E. Boundy, J. Nelson","doi":"10.1038/s41372-024-02139-3","DOIUrl":"10.1038/s41372-024-02139-3","url":null,"abstract":"To describe breastfeeding-supportive practices in U.S. maternity hospitals with advanced neonatal care units (ANCU). Using 2022 mPINC data, we calculated the percent of hospitals reporting (1) breastfeeding-supportive practices for “most” (≥80%) mother-baby dyads in ANCUs, by hospital demographic characteristics and (2) infant receipt of mother’s own milk or donor milk at any time while in the ANCU, by ANCU level. More than 90% of hospitals reported that “most” mothers (≥80%) were advised on some breastfeeding-supportive practices. Fewer hospitals reported that “most” mothers expressed milk within one hour of birth (37%) or that kangaroo care was practiced for “most” eligible newborns (63%). Receipt of mother’s own milk varied by unit level and state. Breastfeeding-supportive practices requiring the technical competency of healthcare providers (e.g., early milk expression, kangaroo care) are less likely to be implemented in ANCU settings compared to practices centered around providing advice or education.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"44 11","pages":"1560-1566"},"PeriodicalIF":2.4,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Genevieve L. Buser, Horia Marginean, Mayen Dada, Savannah Woodward, Alexis Young, Chiayi Chen, Mark W. Tomlinson
{"title":"Hepatitis C infection screening and connection to care among postpartum patients and exposed infants in two community hospitals, 3-year follow-up — Oregon, 2019–2024","authors":"Genevieve L. Buser, Horia Marginean, Mayen Dada, Savannah Woodward, Alexis Young, Chiayi Chen, Mark W. Tomlinson","doi":"10.1038/s41372-024-02138-4","DOIUrl":"10.1038/s41372-024-02138-4","url":null,"abstract":"Determine prevalence of hepatitis C virus (HCV) positivity among postpartum patients to inform prenatal screening recommendations, postpartum connection to care, and infant HCV screening practices. Convenience sample of postpartum patients at one urban and one suburban hospital to undergo rapid fingerstick testing for hepatitis C antibodies. Of 2060 postpartum participants successfully screened, 20 (0.97%) had evidence of past or current HCV infection. One co-infection with syphilis occurred. After a median follow-up of 3.75 years, 6 of 12 participants (50.0%) with chronic HCV infection completed treatment with cure, and 9 of 20 infants (45.0%) completed screening. One neonatal transmission event occurred (5.8%). HCV infection was more common in our postpartum population than other viral infections routinely screened for during pregnancy. Efforts to decrease perinatal HCV transmission should focus on early postpartum connection to treatment team, early screening in infants aged 2–6 months, and pediatric test completion.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"45 1","pages":"122-127"},"PeriodicalIF":2.4,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Albertina Lee, Joern-Hendrik Weitkamp, Angie Tune, Jim Couto, Krithika Lingappan
{"title":"Success and opportunities of the American Academy of Pediatrics Marshall Klaus research grant program in neonatal-perinatal medicine.","authors":"Albertina Lee, Joern-Hendrik Weitkamp, Angie Tune, Jim Couto, Krithika Lingappan","doi":"10.1038/s41372-024-02137-5","DOIUrl":"https://doi.org/10.1038/s41372-024-02137-5","url":null,"abstract":"<p><strong>Background: </strong>Physician-scientists are a crucial link between clinical practice and research. The American Academy of Pediatrics (AAP) initiated the Marshall Klaus Perinatal Research Award to enhance the development of research skills among physicians training in Neonatal-Perinatal Medicine.</p><p><strong>Methods: </strong>In this study, we sought to identify trends in funding along with geographical and demographic variables of the applicants and mentees and assess the applicants' scholarly productivity and funding from the National Institutes of Health (NIH). We reviewed the data of applicants and awardees from 2015-2024.</p><p><strong>Results: </strong>We found that basic science applications had a higher funding likelihood than clinical/translational applications. The geographical distribution of awardees is skewed. There was a significant association between awardee status and K08 or K23 funding attainment.</p><p><strong>Conclusions: </strong>Future efforts should support more equitable award distribution and a diverse research landscape in neonatal-perinatal medicine.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Avery Zierk, Mary Jo Gumbel, Rachel Mackenzie, Kelle Matthews, Francis Simmons, Anna Bustin, Christina DeFelice, Heidi Morris, Leane Soorikian, Kimberly Swartz, Amanda Nickel, Kathleen Gibbs
{"title":"A quality improvement initiative to reduce excess inhaled therapy use in the neonatal intensive care unit.","authors":"Avery Zierk, Mary Jo Gumbel, Rachel Mackenzie, Kelle Matthews, Francis Simmons, Anna Bustin, Christina DeFelice, Heidi Morris, Leane Soorikian, Kimberly Swartz, Amanda Nickel, Kathleen Gibbs","doi":"10.1038/s41372-024-02132-w","DOIUrl":"https://doi.org/10.1038/s41372-024-02132-w","url":null,"abstract":"<p><strong>Objective: </strong>Inhaled medications are commonly used at our single-center, Level IV neonatal intensive care unit (NICU). We lacked a standardized process for measuring efficacy of these medications to guide optimal duration of use, potentially leading to their overuse.</p><p><strong>Methods: </strong>We utilized quality improvement methodology to reduce the length of inhaled hypertonic saline (HTS) course durations and high frequency albuterol use. Interventions included education, data sharing, and implementation of a respiratory therapy assessment tool.</p><p><strong>Results: </strong>The average inhaled HTS course duration decreased from 8.7 to 4.2 days. The percentage of q4 albuterol administrations per total albuterol doses administered monthly decreased from 39 to 20%.</p><p><strong>Conclusion: </strong>Developing a shared mental model between interprofessional providers for the indication and effect of inhaled agents and standardizing assessment of these medications' efficacy can reduce their overuse.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Venkatasai Devarapalli, Makenzie Niven, Jared Canonigo, Beverly Spray, Indirapriya Avulakunta, Jared Beavers, Jennifer Andrews, Vikramaditya Dumpa
{"title":"Prophylactic dextrose gel use in newborns at risk for hypoglycemia","authors":"Venkatasai Devarapalli, Makenzie Niven, Jared Canonigo, Beverly Spray, Indirapriya Avulakunta, Jared Beavers, Jennifer Andrews, Vikramaditya Dumpa","doi":"10.1038/s41372-024-02133-9","DOIUrl":"10.1038/s41372-024-02133-9","url":null,"abstract":"To assess the impact of prophylactic dextrose gel on short-term outcomes in infants at risk for hypoglycemia. Retrospective, single-center, observational study of neonates at risk for hypoglycemia -infants of diabetic mothers, large and small for gestational age infants, born between January 2015 and May 2023. Infants were categorized into two groups for analysis. 1. Pre- dextrose gel (01/2015 to 04/2018, n = 788) and 2. Dextrose gel (01/2019 to 05/2023, n = 1495). Infant demographic data and outcome variables were compared between the two groups. 2283 infants were eligible. Prophylactic dextrose gel use was associated with decreased admission rates to NICU secondary to hypoglycemia (2.7% vs. 6.5%), reduced incidence of hypoglycemia (32% vs. 43.3%), and higher exclusive breastmilk use at discharge (47% vs. 37.3%). The use of prophylactic dextrose gel in certain high-risk newborns was associated with improved patient outcomes.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"44 11","pages":"1640-1646"},"PeriodicalIF":2.4,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pradeep Kumar Velumula, Praveen Kumar Boddu, Luna Khanal, Sanket Jani, Nithi Fernandes, Ronald Thomas, Monika Bajaj, Sanjay Chawla
{"title":"Association of antenatal steroid administration with neonatal morbidities among late preterm multiple gestation infants","authors":"Pradeep Kumar Velumula, Praveen Kumar Boddu, Luna Khanal, Sanket Jani, Nithi Fernandes, Ronald Thomas, Monika Bajaj, Sanjay Chawla","doi":"10.1038/s41372-024-02130-y","DOIUrl":"10.1038/s41372-024-02130-y","url":null,"abstract":"There is limited evidence on the efficacy of antenatal steroids (ANS) among women with multiple gestations at risk of late preterm delivery. This retrospective study included multiple gestation, late preterm infants (340/7–366/7 weeks’ gestational age), born between January 2013 and December 2022. The primary outcome was composite respiratory outcome, defined as the need for respiratory support by 72 hours of age. Logistic and linear regressions were performed to compare the primary and secondary outcomes with and without exposure to any ANS, adjusted for gestational age, sex of infant, histologic chorioamnionitis, and intrauterine growth restriction. The composite respiratory outcome was significantly lower in any ANS group compared to no ANS group (28.6% vs. 33.7%) [adjusted odds ratio 0.50, 95% CI, 0.33–0.75, p < 0.001]. In late preterm multiple gestation infants, any ANS exposure was associated with lower risk of composite respiratory outcome.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"45 1","pages":"24-29"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}