早期肠外脂质摄入支持早产儿足月期小脑神经代谢。

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-06-23 DOI:10.1038/s41372-025-02336-8

Sudeepta K Basu, Katherine M Ottolini, Kushal J Kapse, Julius Ngwa, Steve C N Hui, Nickie Andescavage, Jonathan Murnick, Adre J du Plessis, Catherine Limperopoulos

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引用次数: 0

摘要

目的：关键的早期肠外营养对早产儿大脑神经代谢的影响尚不清楚。本研究描述了肠道外脂质和热量摄入与小脑神经代谢物的关系。方法：在一项前瞻性观察队列研究中，早产儿[出生≤32周胎龄（GA）]在足月时接受了小脑体素的质子磁共振波谱（1H-MRS）采集。通过图表复习计算生命前4周的肠外脂质和热量摄入（g/kg/d或kcal/kg/d）。结果：48例出生年龄28.3±2.4周的早产儿在经后38.9±1.9周行1H-MRS检查。小脑n -乙酰天冬氨酸[NAA]与4周肠外脂质（Rho = 0.4, p = 0.005）和热量（Rho = 0.3, p = 0.047）摄入呈正相关。谷氨酸[Glx]表现出积极的趋势。经协变量调整后，4周的肠外脂质摄入与较高的NAA （B系数= 0.89,p = 0.003）和Glx （B = 1.72, p = 0.045）相关。结论：肠外脂质摄入与较高的小脑NAA和Glx浓度相关，支持早产儿的大脑发育。

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Early parenteral lipid intake supports cerebellar neurometabolism at term-age in preterm infants.

Objectives: The impact of crucial early parenteral nutrition on neurometabolism of the preterm brain remains unclear. This study characterizes the relationship of parenteral lipid and caloric intake with cerebellar neurometabolites.

Methods: Very premature infants [born ≤32-week gestational age (GA)] in a prospective observational cohort study underwent a proton magnetic resonance spectroscopy (¹H-MRS) acquisition from a cerebellar voxel at term-age. Parenteral lipid and caloric intake (g/kg/d or kcal/kg/d) in the first 4 weeks of life were calculated by chart review.

Results: 48 preterm infants born at 28.3 ± 2.4 weeks GA underwent ¹H-MRS at 38.9 ± 1.9 weeks postmenstrual age. Cerebellar N-acetylaspartate [NAA] positively correlated with 4-week parenteral lipid (Rho = 0.4, p = 0.005) and caloric (Rho = 0.3, p = 0.047) intake. Glutamate [Glx] demonstrated a positive trend. Adjusted for covariates, 4-week parenteral lipid intake was associated with higher NAA (B coefficient = 0.89, p = 0.003) and Glx (B = 1.72, p = 0.045).

Conclusions: Parenteral lipid intake is associated with higher cerebellar NAA and Glx concentrations, supporting brain development in preterm infants.

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.