Association of low shunt burden from PDA and adverse outcomes in premature infants.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-09-20 DOI:10.1038/s41372-025-02437-4

Chase Brandt, Hatice Dilara Mat, Adrianne R Bischoff, Patrick J McNamara, Danielle R Rios

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引用次数: 0

Abstract

Objective: Compare the incidence of death or adverse respiratory outcome in patients with low shunt burden from PDA to those with no PDA and evaluate secondary outcomes associated with PDA between groups.

Study design: Retrospective cohort study of all infants born <30 weeks gestation from 8/2018 to 5/2023 with TNE in the first postnatal week. Two groups: no PDA burden and low PDA burden. Primary outcome was composite of death or adverse respiratory outcome.

Results: 112 infants [no PDA (n = 69), low PDA burden (n = 43)] with mean gestational age and birth weight 27 ± 2 weeks and 1006 ± 310 g, respectively, were included. Baseline demographics were comparable with no difference in primary outcome (p = 0.2).

Conclusion: Prolonged exposure to low-volume PDA shunt was not associated with increased risk of death or abnormal respiratory outcome. Findings highlight the importance of redefining eligibility criteria for PDA trials, based on adjudication of shunt volume, to limit enrollment to patients with moderate- to high-volume shunts.

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PDA低分流负担与早产儿不良结局的关系。

目的：比较低分流负荷PDA患者与无PDA患者的死亡或不良呼吸结局发生率，并评估两组之间与PDA相关的次要结局。研究设计：所有出生婴儿的回顾性队列研究结果：纳入112例婴儿[无PDA (n = 69)，低PDA负担（n = 43）]，平均胎龄和出生体重分别为27±2周和1006±310 g。基线人口统计学具有可比性，主要结局无差异（p = 0.2）。结论：长期暴露于小容量PDA分流器与死亡风险增加或呼吸结果异常无关。研究结果强调了重新定义PDA试验资格标准的重要性，该标准基于分流器容量的判定，以限制中等至高容量分流器患者的入组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.