Comparison of neurodevelopmental outcomes of extremely preterm infants undergoing trans-catheter closure of the patent ductus arteriosus compared to surgical ligation.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-09-23 DOI:10.1038/s41372-025-02417-8

D C Kaluarachchi, V Y Chock, B T Do, M A Rysavy, M N Sankar, M M Laughon, C H Backes, T T Colaizy, E F Bell, P J McNamara, S R Hintz, G Natarajan

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引用次数: 0

Abstract

Background: There is a paucity of data on neurodevelopmental outcomes in preterm infants who undergo transcatheter patent ductus arteriosus (PDA) closure (TCPC).

Objective: To evaluate neurodevelopmental impairment (NDI) or death at 2 years among preterm infants treated with TCPC compared to surgical ligation.

Methods: Retrospective cohort study of infants born at <27 weeks' gestation at NICHD NRN sites. Comparisons were made between infants who underwent TCPC and PDA ligation.

Results: TCPC and surgical ligation were performed on 99 and 279 infants, respectively. Death or severe NDI occurred in 49% of infants with TCPC and 40% with surgical ligation. There was no difference in odds of death or severe NDI between the two groups [aOR 1.12 95% CI: 0.55-2.26)].

Conclusion: TCPC had similar odds of death or severe NDI compared to surgical ligation. These findings need to be evaluated in large prospective studies as the management practice around the TCPC evolves.

Clinical trial registration: ClinicalTrials.gov ID: Generic Database: NCT00063063.

查看原文本刊更多论文

经导管关闭动脉导管未闭与手术结扎对极早产儿神经发育的影响。

背景：关于经导管动脉导管未闭（PDA）闭合（TCPC）的早产儿神经发育结局的数据缺乏。目的：与手术结扎相比，评估TCPC治疗早产儿2岁时神经发育障碍（NDI）或死亡。结果：分别对99例和279例患儿行TCPC和结扎手术。49%的TCPC婴儿死亡或严重NDI， 40%的TCPC婴儿手术结扎。两组患者死亡或严重NDI的几率无差异[aOR 1.12 95% CI: 0.55-2.26)]。结论：与手术结扎相比，TCPC的死亡或严重NDI的几率相似。随着围绕TCPC的管理实践的发展，这些发现需要在大型前瞻性研究中进行评估。临床试验注册：ClinicalTrials.gov ID：通用数据库：NCT00063063。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.