Antibiotic exposure and infection epidemiology among newborns with congenital diaphragmatic hernia

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-08-18 DOI:10.1038/s41372-025-02389-9

Sabrina J. Flohr, Leny Mathew, Holly L. Hedrick, Natalie E. Rintoul, Talene A. Metjian, Sanjeev K. Swami, Jeffrey S. Gerber, Alexandra K. Medoro, Dustin D. Flannery

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Abstract

To describe infection epidemiology and measure antibiotic utilization among a large cohort of newborns with congenital diaphragmatic hernia (CDH). Retrospective observational study including inborn newborns with CDH at a level IV referral center (free-standing children’s hospital with special delivery unit) and two associated level III birth centers who underwent active care and survived to NICU admission, born 1/2013-11/2022 with available disposition. Of 381 newborns with CDH who were admitted to the NICU, 370 (97.1%) received antibiotics. There were 137 (36.1%) newborns with a positive bacterial culture from any source; 78/381 (20.4%) had a positive culture from blood, urine, or spinal fluid. Nearly all newborns with CDH at our center received antibiotics during their hospitalization, but the majority did not have a positive bacterial culture result, indicating opportunities exist for antibiotic stewardship among this population.

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新生儿先天性膈疝抗生素暴露与感染流行病学。

目的：了解新生儿先天性膈疝（CDH）感染流行病学及抗生素使用情况。研究设计：回顾性观察性研究，包括在IV级转诊中心（设有特殊分娩单元的独立儿童医院）和两个相关的III级分娩中心出生的CDH新生儿，这些新生儿接受了积极的护理并存活到NICU入住，出生于2013年1月至2022年11月，有可用的处置。结果：381例新生儿CDH入住NICU， 370例（97.1%）接受抗生素治疗。细菌培养阳性137例（36.1%）新生儿；78/381（20.4%）的血、尿或脊髓液培养呈阳性。结论：本中心几乎所有CDH新生儿在住院期间都接受了抗生素治疗，但大多数患者的细菌培养结果未呈阳性，这表明在这一人群中存在抗生素管理的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.