Journal of Perinatology最新文献_第7页

Effect of therapeutic hypothermia on surfactant proteins, anti-inflammatory and pro-fibrotic mediators. 治疗性低温对表面活性蛋白、抗炎和促纤维化介质的影响。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-02 DOI: 10.1038/s41372-025-02285-2

Chiara Autilio, Lhousseine Touqui, Silvia Foligno, Raquel Arroyo, Paul S Kingma, Alejandro A Alonso, Jesus Perez-Gil, Daniele De Luca

{"title":"Effect of therapeutic hypothermia on surfactant proteins, anti-inflammatory and pro-fibrotic mediators.","authors":"Chiara Autilio, Lhousseine Touqui, Silvia Foligno, Raquel Arroyo, Paul S Kingma, Alejandro A Alonso, Jesus Perez-Gil, Daniele De Luca","doi":"10.1038/s41372-025-02285-2","DOIUrl":"https://doi.org/10.1038/s41372-025-02285-2","url":null,"abstract":"Objectives: To study the effect of hypothermia on surfactant proteins, anti-inflammatory and pro-fibrotic mediators DESIGN: Prospective, pragmatic study enrolling asphyxiated neonates without lung injury. Surfactant proteins (SP), Club cell secretory protein (CC-10), tumor growth factor-β1 (TGF-β1), human fibroblast growth factor-2 (hFGF) and anti-inflammatory interleukins (IL) were measured in broncho-alveolar lavage fluids obtained before, during and after hypothermia.Results: Twelve neonates were studied. SP-A, -B, -C, -D and CC-10 levels were similar before, during and after hypothermia. IL-10, IL-13, IL-14 were inconsistently detected only in five out of twelve patients and not in all timepoints; TGF-β1 was always undetectable. hFGF decreased during hypothermia (pre = 92 [52-193.6], during = 19.4 [0-42.6], post = 31.8 [0-83] ng/mL, p = 0.026) with levels before hypothermia being significantly higher than those obtained during and after the treatment (post hoc p = 0.025).Conclusions: In cooled neonates without any lung disorder, hypothermia is associated with lower hFGF but not with any changes in surfactant proteins or anti-inflammatory molecules.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of congenital heart disease and prematurity on brain injury from a national registry. 先天性心脏病和早产对脑损伤的影响

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-02 DOI: 10.1038/s41372-025-02281-6

Giulia P Lima, Sarah U Morton, Isabella Zaniletti, Philip Levy, Nathaly Sweeney, Leeann Pavlek, Shannon E G Hamrick, Sharada H Gowda, Rakesh Rao, Molly K Ball, Paulomi M Chaudhry

引用次数: 0

A pilot study of a virtual reality-based simulation platform for Neonatal Resuscitation Program training. 新生儿复苏计划培训虚拟现实模拟平台试点研究。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-01 Epub Date: 2024-10-14 DOI: 10.1038/s41372-024-02145-5

GiaKhanh Trinh, Ryan M McAdams

{"title":"A pilot study of a virtual reality-based simulation platform for Neonatal Resuscitation Program training.","authors":"GiaKhanh Trinh, Ryan M McAdams","doi":"10.1038/s41372-024-02145-5","DOIUrl":"10.1038/s41372-024-02145-5","url":null,"abstract":"Objective: This pilot implementation study introduces a novel, neonatal-specific virtual reality (VR) simulation platform for resuscitation training and assesses its initial feasibility and reception in a neonatal intensive care unit setting.Study design: We developed a custom VR model simulating a resuscitation scenario for a 30-week neonate. Neonatal providers completed individualized training sessions and post-training surveys.Results: Thirty-eight neonatal providers participated in the study. The VR platform was well-received, with 97% willing to use it again and 95% recommending it. Most participants (70.3%) found VR more realistic than traditional methods, with an average usefulness rating of 4.5/5. However, 40.5% reported adverse effects like eye strain and motion sickness. Feedback led to three significant VR platform upgrades.Conclusion: This study demonstrates strong enthusiasm for VR among neonatal providers. While promising, further research with larger samples and comparisons to traditional methods is needed to fully evaluate VR's effectiveness in neonatal resuscitation training.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"521-526"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of video review to enhance recognition of intubation attempt duration and success in fetal care center delivery room resuscitations. 利用视频回顾提高对胎护中心产房复苏插管尝试时间和成功的认识。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-01 Epub Date: 2025-02-25 DOI: 10.1038/s41372-025-02240-1

Morgan E Hill, Jae H Kim, Stefanie Riddle

引用次数: 0

Meta-analysis and Mendelian randomization study on the association between exposure to chlorinated disinfection byproducts and preterm birth risk. 氯化消毒副产物暴露与早产风险关系的荟萃分析和孟德尔随机化研究。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-01 Epub Date: 2025-01-09 DOI: 10.1038/s41372-024-02195-9

Changxia Cheng, Yanling Pei, Guangyu Shan, Yutao Liu

{"title":"Meta-analysis and Mendelian randomization study on the association between exposure to chlorinated disinfection byproducts and preterm birth risk.","authors":"Changxia Cheng, Yanling Pei, Guangyu Shan, Yutao Liu","doi":"10.1038/s41372-024-02195-9","DOIUrl":"10.1038/s41372-024-02195-9","url":null,"abstract":"Objective: This study aims to investigate the correlation between exposure to disinfection byproducts of chlorination and preterm birth (PTB) through evidence-based medicine Meta-analysis and Mendelian randomization (MR) analysis.Study design: Meta-analysis was conducted on 17 studies involving 1,251,426 neonates, revealing a higher risk of PTB with exposure to total trihalomethanes (TTHMs) and chloroform. Mendelian randomization (MR) analysis confirmed a causal relationship between chlorides and PTB.Results: TTHMs and chloroform were associated with increased PTB risk, while haloacetic acids showed no significant association. TTHMs were linked to small gestational age. Ethnicity and study design influenced heterogeneity.Conclusions: Exposure to chlorination byproducts, particularly TTHMs and chloroform, poses a significant risk for PTB. MR analysis supports a causal relationship between chlorides and PTB, highlighting the importance of water disinfection byproduct control in preventing PTB.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"438-447"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes, safety and health economics of introduction of video laryngoscopy-assisted less invasive surfactant administration. 引入视频喉镜辅助微创表面活性给药的结果、安全性和卫生经济学。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-01 Epub Date: 2024-11-22 DOI: 10.1038/s41372-024-02162-4

Venkata Gupta, Barry Weinberger, Stephanie G Galanti, Jimikumar Patel, Gangajal Kasniya, Dalibor Kurepa

{"title":"Outcomes, safety and health economics of introduction of video laryngoscopy-assisted less invasive surfactant administration.","authors":"Venkata Gupta, Barry Weinberger, Stephanie G Galanti, Jimikumar Patel, Gangajal Kasniya, Dalibor Kurepa","doi":"10.1038/s41372-024-02162-4","DOIUrl":"10.1038/s41372-024-02162-4","url":null,"abstract":"Background: Less invasive surfactant administration (LISA) is associated with better outcomes than InSurE (Intubation-Surfactant administration-Extubation). Video-laryngoscopy (VL) facilitates intubation in neonates, however safety and cost-effectiveness of VL-assisted LISA have not been evaluated.Methods: We compared the outcomes of infants receiving VL-assisted LISA (n = 67) with a historical cohort of infants who received InSurE (n = 52). Secondary aims were to evaluate safety and cost-effectiveness.Results: VL-assisted LISA was associated with reduced duration of non-invasive ventilation (NIV), reduced duration of oxygen therapy, reduced composite days on NIV and mechanical ventilation (MV), and shorter NICU stay with lower hospital costs for infants ≥29 weeks GA, compared to InSurE. In the VL-assisted LISA group, 66% of the tracheal catheters were placed on the first attempt and 16% of infants displayed desaturation during placement.Conclusion: In infants ≥29 weeks GA, VL-assisted LISA reduced exposure to NIV, oxygen, NIV and MV combined, length of stay, and cost of care compared to InSurE.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"513-520"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic accuracy and short-term implications of prenatally diagnosed vascular rings: a single center study. 产前诊断血管环的诊断准确性和短期意义：一项单中心研究。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-01 Epub Date: 2025-03-04 DOI: 10.1038/s41372-025-02244-x

Nicolle M Ceneri, Michelle L Udine, Manan H Desai, Steven J Staffa, Wendy Ho, Leanne Buckels, Stephanie R Lacey, Mary T Donofrio

{"title":"Diagnostic accuracy and short-term implications of prenatally diagnosed vascular rings: a single center study.","authors":"Nicolle M Ceneri, Michelle L Udine, Manan H Desai, Steven J Staffa, Wendy Ho, Leanne Buckels, Stephanie R Lacey, Mary T Donofrio","doi":"10.1038/s41372-025-02244-x","DOIUrl":"10.1038/s41372-025-02244-x","url":null,"abstract":"Objective: To assess the diagnostic accuracy and postnatal outcomes of fetuses with a suspected vascular ring (VR).Study design: Single-center retrospective study of patients with suspected VR by fetal echocardiography. Postnatal evaluation included echocardiography +/- cross-sectional imaging. Outcomes, including symptomatology and surgery, were recorded and compared between VR types.Results: Of 68 suspected fetal VRs, 81% were confirmed postnatally. Concordance between fetal and postnatal anatomy was 76%. Five neonates required resuscitation unrelated to VR. Symptoms presented in 13 patients (median 45 days), independent of VR type. Surgical intervention was performed in 15 patients (median 99 days); 80% were symptomatic. At a median follow-up of 6 months, 4 patients were symptomatic including 3 postoperative.Conclusions: Fetal echocardiography accurately identifies and characterizes VR anatomy in most instances. Specialized delivery planning in uncomplicated cases is unnecessary given absence of symptoms at birth. Fetal diagnosis may not indicate surgical disease, as symptoms do not occur in all and early surgery does not guarantee symptom resolution.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"487-494"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perfluoroalkyl substances and preterm birth. 全氟烷基物质与早产。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-01 Epub Date: 2025-02-18 DOI: 10.1038/s41372-025-02231-2

Anne M Mullin, Abby F Fleisch, Clementina Mesaros, Rachel Ledyard, Michele R Hacker, Heather H Burris

引用次数: 0

Buprenorphine vs. morphine: impact on neonatal opioid withdrawal syndrome (NOWS) outcomes in a single center retrospective study. 丁丙诺啡与吗啡：单中心回顾性研究对新生儿阿片类药物戒断综合征（NOWS）结果的影响。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-01 Epub Date: 2024-07-13 DOI: 10.1038/s41372-024-02046-7

Saminathan Anbalagan, Victoria Anderson, Michael T Favara, Daniela Stark, David Carola, Kolawole Solarin, Susan Adeniyi-Jones, Walter K Kraft, Zubair H Aghai

{"title":"Buprenorphine vs. morphine: impact on neonatal opioid withdrawal syndrome (NOWS) outcomes in a single center retrospective study.","authors":"Saminathan Anbalagan, Victoria Anderson, Michael T Favara, Daniela Stark, David Carola, Kolawole Solarin, Susan Adeniyi-Jones, Walter K Kraft, Zubair H Aghai","doi":"10.1038/s41372-024-02046-7","DOIUrl":"10.1038/s41372-024-02046-7","url":null,"abstract":"Objectives: To compare clinical outcomes for infants with neonatal opioid withdrawal syndrome (NOWS) treated with buprenorphine or morphine.Study design: Retrospective study of infants born ≥35 weeks' gestation and admitted to the NICU for NOWS treatment between 2011 and 2022. Length of treatment, length of stay in the hospital, and the need for secondary medications were compared between buprenorphine and morphine treated neonates. Multiple regression analysis was performed, adjusting for baseline differences and confounders.Results: 417 neonates were treated with morphine and 232 with buprenorphine. The buprenorphine group had shorter treatment days [-10.8 days; 95% CI: -8.08 to -13.53] and shorter hospital stay [-11.8 days; 95% CI: -8.83 to -14.78]. The buprenorphine group was no more likely to receive phenobarbital or clonidine (26% vs. 29%).Conclusion: In this large single-center study, buprenorphine was associated with shorter lengths of treatment and hospital stay in the treatment of NOWS compared to morphine.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"473-479"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outpatient tapering of buprenorphine in opioid use disorder pregnancies may improve neonatal outcomes. 门诊减少丁丙诺啡在阿片类药物使用障碍妊娠可能改善新生儿结局。

IF 2.4 3区医学

Journal of Perinatology Pub Date : 2025-04-01 Epub Date: 2025-02-10 DOI: 10.1038/s41372-025-02211-6

Darshan Shah, Rakesh Adelli, Alyson Chroust, Nicole Lewis, Martin Olsen

{"title":"Outpatient tapering of buprenorphine in opioid use disorder pregnancies may improve neonatal outcomes.","authors":"Darshan Shah, Rakesh Adelli, Alyson Chroust, Nicole Lewis, Martin Olsen","doi":"10.1038/s41372-025-02211-6","DOIUrl":"10.1038/s41372-025-02211-6","url":null,"abstract":"Objective: The main objective of the study was to compare neonatal outcomes: the incidence of NOWS, length of hospital stay (LOS), admission to neonatal intensive care (NICU), birth weight, treatment with morphine, and head circumference between newborns of mothers who had tapering of buprenorphine (T group) during pregnancy to non-tapering of buprenorphine (NT group).Study design: It was a prospective, pilot, case-control trial of pregnant women done in North-East Tennessee in pregnancy with opioid use disorder (OUD) in the tapered (T) group as a part of clinical care while the NT group did not taper medication.Results: Significant differences were observed among neonatal outcomes; average birth weight and head circumference (p < 0.05) and admission to NICU (p < 0.05) between the two groups by t-test, and in maternal buprenorphine doses, 1.47 versus 7.6 (p < 0.0001).Conclusion: Comprehensive outpatient buprenorphine tapering can be done in OUD pregnancy with improved neonatal outcomes after careful discussion with providers of the risks and benefits.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"480-486"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0