{"title":"Does intratracheal budesonide mixed with surfactant increase survival without bronchopulmonary dysplasia in extremely preterm infants?","authors":"Giulia P Lima, Kristen T Leeman","doi":"10.1038/s41372-025-02391-1","DOIUrl":"https://doi.org/10.1038/s41372-025-02391-1","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evidence on the effect of in-utero cannabis exposure in neonates.","authors":"Basel Thayyil, Kamran Yusuf","doi":"10.1038/s41372-025-02383-1","DOIUrl":"https://doi.org/10.1038/s41372-025-02383-1","url":null,"abstract":"<p><p>The global prevalence of cannabis use during pregnancy is increasing, driven by perceived therapeutic benefits and greater societal acceptance. Concurrently, the psychoactive potency of cannabis products has risen significantly, due to increase in concentrations of Tetrahydrocannabinol (THC) from 5% to 30%. THC crosses the placenta, disrupts the endocannabinoid system critical for neurodevelopment, and accumulates in fetal tissues. THC is transferred into breast milk, with breastfed infants receiving ~2.5% of the maternal dose, raising concerns regarding neurodevelopmental consequences. An increasing number of studies and metanalysis have demonstrated association of prenatal cannabis exposure with low birth weight, preterm birth, neonatal intensive care unit admission, and reduced Apgar scores. Longitudinal studies show brain alterations in offspring, affecting memory, attention, and executive function. The inability to conduct randomized controlled trials due to ethical constraints necessitates reliance on observational studies, underscoring the need for rigorous longitudinal research to delineate causality.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emily A Messick, Stephen A Hart, Julie Strominger, Sara Conroy, Carl H Backes, Clifford L Cua
{"title":"Gestational age-based outcomes of neonates with Down syndrome in the neonatal intensive care unit (NICU): review of pediatric health information system (PHIS) database.","authors":"Emily A Messick, Stephen A Hart, Julie Strominger, Sara Conroy, Carl H Backes, Clifford L Cua","doi":"10.1038/s41372-025-02384-0","DOIUrl":"https://doi.org/10.1038/s41372-025-02384-0","url":null,"abstract":"<p><strong>Objective: </strong>To examine differences in neonatal intensive care unit (NICU) outcomes in neonates with Down syndrome (DS) by gestational age (GA) using a large national database STUDY DESIGN: Retrospective analysis of Pediatric Health Information System database, including neonates with DS admitted to the NICU <30 days old from 1/1/2008-12/31/2022. Neonates were stratified by GA (extremely preterm, very preterm, moderate/late preterm, term). GA-based risk differences were examined for NICU outcomes using term neonates as reference.</p><p><strong>Results: </strong>Overall mortality rate was 7% with increasing mortality as GA decreased (RD 6.1 [95% CI 4.8, 7.5], RD 25.4 [95% CI 20.5, 30.6], RD 36.8 [95% CI 27.3, 46.8] for moderate/late preterm, very preterm, extremely preterm). The overall rate of pulmonary hypertension was 23% and 14% of the cohort required a gastrostomy tube.</p><p><strong>Conclusion: </strong>Prematurity significantly increases risk of NICU mortality for neonates with DS. Rates of pulmonary hypertension and gastrostomy were high throughout all groups.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fu-Sheng Chou, Hung-Wen Yeh, Crystal Hsueh, Jing Zhang, Maria Fe B Villosis, Karine Barseghyan, Ashwini Lakshmanan, Reese H Clark
{"title":"Categorizing weight growth of infants born before 32 weeks' gestation using the 2023 postnatal growth charts for preterm infants.","authors":"Fu-Sheng Chou, Hung-Wen Yeh, Crystal Hsueh, Jing Zhang, Maria Fe B Villosis, Karine Barseghyan, Ashwini Lakshmanan, Reese H Clark","doi":"10.1038/s41372-025-02374-2","DOIUrl":"https://doi.org/10.1038/s41372-025-02374-2","url":null,"abstract":"<p><strong>Objective: </strong>To categorize growth and correlate growth categories with morbidities in infants born before 32 weeks of gestation.</p><p><strong>Study design: </strong>This retrospective study categorized weight growth by correlating mean growth velocity (GV) with growth trajectory z-score changes ( <math><mi>Δ</mi> <mi>G</mi> <mi>T</mi> <mi>Z</mi></math> ), as measured using 2023 Postnatal Growth Charts for Preterm Infants. The associations between weight categories and morbidities were assessed.</p><p><strong>Results: </strong>Weight gain of infants without morbidities was categorized into three groups based on correlating <math><mi>Δ</mi> <mi>G</mi> <mi>T</mi> <mi>Z</mi></math> with mean GV: slower ( <math><mi>Δ</mi> <mi>G</mi> <mi>T</mi> <mi>Z</mi></math> < -0.1), in-parallel ( <math><mi>Δ</mi> <mi>G</mi> <mi>T</mi> <mi>Z</mi></math> -0.1 to 0.3), and faster ( <math><mi>Δ</mi> <mi>G</mi> <mi>T</mi> <mi>Z</mi></math> > 0.3). The proportions of infants with and without morbidities in these categories were evaluated across two distinct cohorts, revealing similar patterns. Both slower and faster growth were associated with bronchopulmonary dysplasia, while only slower growth was associated with retinopathy of prematurity.</p><p><strong>Conclusion: </strong>Using the 2023 Postnatal Growth Charts for Preterm Infants, this study presents an alternative method for weight growth categorization.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mathies Rondagh, Margot J A van de Sande, Lisanne S A Tollenaar, Sylke J Steggerda, Jeanine M M van Klink, Linda S de Vries, Femke Slaghekke, Sophie G Groene, Enrico Lopriore
{"title":"Twin anemia polycythemia sequence and the risk of iron deficiency in donors and iron overload in recipients.","authors":"Mathies Rondagh, Margot J A van de Sande, Lisanne S A Tollenaar, Sylke J Steggerda, Jeanine M M van Klink, Linda S de Vries, Femke Slaghekke, Sophie G Groene, Enrico Lopriore","doi":"10.1038/s41372-025-02386-y","DOIUrl":"https://doi.org/10.1038/s41372-025-02386-y","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is administration of corticosteroids in late preterm infant born 34–36 weeks’ gestation associated with adverse childhood neurodevelopment outcomes?","authors":"Zohaib Sayyed, Naveed Hussain","doi":"10.1038/s41372-025-02353-7","DOIUrl":"10.1038/s41372-025-02353-7","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"45 10","pages":"1493-1496"},"PeriodicalIF":2.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Allison Young, Luna Vorster, James Riviello, Duy Dinh, Rita Shah, Jennifer Erklauer, Amir Navaei, Andrea Ontaneda
{"title":"Multimodal neuromonitoring modalities of neonatal patients on extracorporeal membrane oxygenation.","authors":"Allison Young, Luna Vorster, James Riviello, Duy Dinh, Rita Shah, Jennifer Erklauer, Amir Navaei, Andrea Ontaneda","doi":"10.1038/s41372-025-02385-z","DOIUrl":"https://doi.org/10.1038/s41372-025-02385-z","url":null,"abstract":"<p><strong>Objectives: </strong>To describe the neonatal population requiring ECMO; characterize their neurologic injury; summarize multimodal neuromonitoring (MNM) utilized for neonatal ECMO patients; and discern impacts of MNM on patient management.</p><p><strong>Study design: </strong>This retrospective chart review includes neonates admitted from 2019 to 2023 requiring ECMO. Data include patient characteristics; details of neurologic injury; radiographic, electroencephalogram (EEG), and near-infrared spectroscopy (NIRS) findings; and effects of MNM on patient management.</p><p><strong>Results: </strong>Among 53 patients, MNM included head ultrasound (53/53, 100%), continuous EEG (35/53,66%), and NIRS (24/53,45%). The frequency of EEG and NIRS monitoring increased after implementing a MNM protocol. Adverse neurologic events were detected in 18 patients (34%). Responses to MNM findings included change in anticoagulation (12/18,67%), recommending additional neuroimaging (11/18,61%), and anti-seizure medication administration (7/18,39%).</p><p><strong>Conclusion: </strong>MNM during ECMO facilitates timely detection of evolving neurologic injury and informs patient management. Utilizing a MNM protocol increased the number of neonates receiving continuous neuromonitoring.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sabrina Montgomery, Katherine Bianco, Elizabeth B Sherwin, Hayley E Miller, Ruth B Lathi, Stephanie A Leonard
{"title":"Trends in fetal autopsy and placental histopathology following stillbirth, United States, 2014-2023.","authors":"Sabrina Montgomery, Katherine Bianco, Elizabeth B Sherwin, Hayley E Miller, Ruth B Lathi, Stephanie A Leonard","doi":"10.1038/s41372-025-02381-3","DOIUrl":"https://doi.org/10.1038/s41372-025-02381-3","url":null,"abstract":"","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Krystal Austin, Olga Smith, Monica McLemore, Sarah Lewis, Safyer McKenzie-Sampson, Taylor E Washington, Elizabeth E Rogers, Kayla L Karvonen
{"title":"Staff perspectives on racial inequities in the neonatal intensive care unit: the REJOICE study.","authors":"Krystal Austin, Olga Smith, Monica McLemore, Sarah Lewis, Safyer McKenzie-Sampson, Taylor E Washington, Elizabeth E Rogers, Kayla L Karvonen","doi":"10.1038/s41372-025-02378-y","DOIUrl":"https://doi.org/10.1038/s41372-025-02378-y","url":null,"abstract":"<p><strong>Objective: </strong>To understand staff perspectives on racism experienced by both parents and staff members in the neonatal intensive care unit (NICU).</p><p><strong>Study design: </strong>Open-ended surveys and semi-structured interviews were conducted with staff at an urban level IV NICU from 2021 to 2022. Themes were generated and refined using thematic analysis. The main outcome constituted participants' experiences of structural racism.</p><p><strong>Results: </strong>72 multi-disciplinary and racially and ethnically diverse participants completed the survey and 10 participants were also interviewed. Five major themes were identified: (1) a wide range of denial and recognition of racism existed, (2) workplace culture and relationships both protected against and facilitated racism, (3) staff experienced a lack of workforce diversity and minority tax, and witnessed (4) biased communication and language barriers, and (5) disparate resource allocation.</p><p><strong>Conclusions: </strong>Similar to other healthcare worker and caregiver reports, NICU staff members also experience and witness interpersonal, institutional, and structural forms of racism.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marwa A. Khalil, Samantha D’Aversa, Tara Lozy, Nicole T. Spillane
{"title":"The performance of growth charts in well term newborns in screening for hypoglycemia","authors":"Marwa A. Khalil, Samantha D’Aversa, Tara Lozy, Nicole T. Spillane","doi":"10.1038/s41372-025-02373-3","DOIUrl":"10.1038/s41372-025-02373-3","url":null,"abstract":"To compare the performance of Fenton Growth Chart (FGC) with WHO Growth Chart (WGC) to identify term infants at risk for hypoglycemia. A retrospective study of infants screened for hypoglycemia due to SGA or LGA status determined by FGC and/or WGC. Nine hundred and seventy infants were included. There was 47.7% agreement between growth charts. A total of 283 (29.2%) newborns developed hypoglycemia. Of those with hypoglycemia, 53.7% were identified by both charts. WGC was more sensitive for all categories of hypoglycemia examined; hypoglycemia (81.3% [CI 76.2–86.7] vs 72.4% [CI 66.8–77.6]), severe hypoglycemia (80.8% [CI 67.5–90.4] vs 71.2% [CI 56.9–82.9]), and hypoglycemia requiring NICU transfer (88.5% [CI 69.9–97.6] vs 65.4% [CI 44.2–82.8). The FGC was more specific for all hypoglycemia categories. There was poor agreement between WGC and FGC for hypoglycemia in term infants. The WGC was more sensitive in detecting hypoglycemia and was non-inferior to the FGC.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":"45 10","pages":"1352-1359"},"PeriodicalIF":2.4,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41372-025-02373-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}