Journal of Orthopaedic Surgery and Research最新文献

{"title":"Similarities in distribution pattern between acute multiple osteoporotic vertebral compression fractures and vertebral fractures cascades.","authors":"Feng Wang, Rui Sun, Shao-Dong Zhang, Xiao-Tao Wu","doi":"10.1186/s13018-024-05337-z","DOIUrl":"10.1186/s13018-024-05337-z","url":null,"abstract":"<p><strong>Backgroud: </strong>Osteoporotic vertebral compression fractures (OVCF) cascades (OVCFcs) repeatedly cause vertebral compression to involve multiple vertebra. This study aimed to introduce an accelerated form of OVCFcs: acute multiple OVCF (amOVCF).</p><p><strong>Methods: </strong>OVCF patients with multiple vertebral augmentations in a spine center between June 2016 and October 2020 were retrospectively studied. Demographics, spine trauma, anatomical distribution, and distribution pattern of OVCF in OVCFcs and amOVCF were summarized and compared.</p><p><strong>Results: </strong>429 patients with multiple vertebral augmentations in 1164 vertebra were included. There were 210 OVCFcs accumulating 622 OVCF and 219 amOVCF simultaneously involving 542 vertebra. The OVCFcs progressed at 0.48 fractures and 0.56 vertebra per year. Both OVCFcs and amOVCF demonstrated asymmetrical bimodal distribution in spine and most frequently involved L1. The incidence of adjacent OVCF was 40.14% in amOVCF with 2 OVCF and 84.72% in amOVCF with ≥ 3 OVCF, and the distribution pattern of OVCF was not significantly different between amOVCF and OVCFcs. The female/male ratio was 5.56 in OVCFcs and not different from that of 4.34 in amOVCF. The age of females (73.41 ± 8.08 and 76.29 ± 8.25 years old) but not males (77.20 ± 10.13 and 79.75 ± 10.21 years old) was significantly increased from initial to last OVCF in OVCFcs. amOVCF had similar age (72.26 ± 10.09 years old) as OVCFcs at initial OVCF (73.99 ± 8.51 years old) and were significantly younger than OVCFcs at last OVCF (76.82 ± 8.64 years old). 54.29% in OVCFcs and 48.4% in amOVCF reported no evident trauma, and the ratio of apparent spine trauma was higher in amOVCF (43.38%) than in OVCFcs (28.54%).</p><p><strong>Conclusions: </strong>amOVCF are accelerated form of OVCFcs showing similar anatomical distribution and distribution pattern of OVCF in spine. Both amOVCF and OVCFcs cause multiple fragility fractures without significant spine trauma.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"19 1","pages":"844"},"PeriodicalIF":2.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11657487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CRNDE alleviates IL-1β-induced chondrocyte damage by modulating miR-31/NF-κB pathway.","authors":"Jiuxiang Liu, Jiangqi Cheng, Hao Zhou, Qiang Zuo, Feng Liu","doi":"10.1186/s13018-024-05182-0","DOIUrl":"10.1186/s13018-024-05182-0","url":null,"abstract":"<p><strong>Background: </strong>The long non-coding RNA CRNDE (CRNDE) has been identified as a lncRNA associated with osteoarthritis (OA), playing a role the age-related degeneration of articular cartilage. However, the precise mechanism by which CRNDE affects the physiological functions of OA chondrocytes remains unclear.</p><p><strong>Methods: </strong>To simulate the inflammatory conditions observed in OA, interleukin (IL)-1β-stimulated chondrocyte C-28/I2 cells were utilized. The expression levels of CRNDE and miR-31 were assessed using reverse transcription-polymerase chain reaction (RT-PCR). Chondrocyte viability and apoptosis were evaluated through CCK-8 assay and flow cytometry, respectively. The levels of IL-6, IL-1β and Tumor necrosis factor (TNF-α) were determined using enzyme-linked immunosorbent assay (ELISA). mRNA expression levels of MMP-13, Aggrecan and COL2A1 were detected by quantitative RT-PCR. Western blot analysis was performed to evaluate the protein levels of factors related to cartilage matrix degradation, including p-p65, p65 and p-IκBα of the NF-κB pathway.</p><p><strong>Results: </strong>CRNDE expression was downregulated in both OA cartilage tissues and IL-1β-stimulated chondrocytes. Overexpression of CRNDE mitigated IL-1β-stimulated chondrocytes apoptosis, inflammatory responses, and cartilage matrix degradation. Compared with healthy controls, OA tissues exhibited reduced expression of miR-31, which was negatively correlated with the expression of CRNDE. Additionally, overexpression of miR-31 partially reversed the inhibitory effects of CRNDE on apoptosis, inflammation, cartilage matrix degradation, and the inactivation of Nuclear factor (NF)-κB pathway induced by IL-1β stimulation. Moreover, silencing of CRNDE exacerbated IL-1β-induced chondrocytes damage, which was aliviated by the NF-κB pathway inhibitor, Bay 11-7082.</p><p><strong>Conclusion: </strong>CRNDE alleviated IL-1β-induced injuries in OA chondrocytes by suppressing the miR-31-mediated NF-κB signaling pathway.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"19 1","pages":"860"},"PeriodicalIF":2.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of cold and cryo-preserved nerve allografts with low-dose FK506 for motor nerve regeneration: a preclinical study.","authors":"Jong Pil Kim, Soon Chul Heo, Dae Hee Lee, Jun Sang Bae, Young Kwang Shin, Su Hyeok Son, Il Yong Park, Hae-Won Kim, Jun Hee Lee, Kyung Wook Kim","doi":"10.1186/s13018-024-05343-1","DOIUrl":"10.1186/s13018-024-05343-1","url":null,"abstract":"<p><strong>Background: </strong>Despite their ability to regenerate as well as autografts, the use of nerve allografts is limited by the need for immunosuppression and the risk of disease transmission. Further, decellularized allografts lacking Schwann cells limit axonal regeneration in long nerve defects. This study evaluated sciatic nerve regeneration in rats implanted with cold- or cryopreserved allografts, and examined the effects of FK506, an immunosuppressant that targets calcineurin function, on motor recovery.</p><p><strong>Methods: </strong>Sixty-five male Lewis rats were divided into five groups of 13, each with a 10-mm sciatic nerve gap. Group I received an autograft, whereas Groups II and III received allografts pretreated with cryopreservation and cold preservation, respectively. Groups IV and V were also implanted with cryo- and cold-preserved allografts, but were treated with a low dose of FK506. Motor regeneration was assessed at 20 weeks by the measurement of ankle contracture, compound muscle action potential, maximal isometric tetanic force, wet muscle weight of the tibialis anterior, peroneal nerve histomorphometry, and immunohistochemistry of the reconstructed sciatic nerve.</p><p><strong>Results: </strong>Similar motor recovery was observed between the autografts and both types of allografts. The groups treated with FK506 showed improved recovery, particularly in terms of ankle angle and tibialis anterior muscle weight. Histomorphometry revealed a superior myelinated fiber area and nerve ratio in the cold-preserved allograft group, while Group II displayed a less well-organized morphology.</p><p><strong>Conclusion: </strong>This study demonstrates that cold- or cryopreserved nerve allografts represent effective alternatives to autografts for peripheral nerve reconstruction, with low-dose FK506 enhancing motor recovery without necessitating immunosuppression.</p><p><strong>Level of evidence i: </strong>Basic Science Level I.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"19 1","pages":"859"},"PeriodicalIF":2.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative intravenous dexamethasone did not reduce the severity of persistent postsurgical pain after total knee arthroplasty: a prospective, randomized, double-blind, placebo-controlled trial.","authors":"Nitchanant Kitcharanant, Prangmalee Leurcharusmee, Pichitchai Atthakomol, Warakorn Jingjit","doi":"10.1186/s13018-024-05362-y","DOIUrl":"10.1186/s13018-024-05362-y","url":null,"abstract":"<p><strong>Background: </strong>Even with the great advancements in recent years in total knee arthroplasty (TKA), some patients continue to have persistent postsurgical pain (PPSP). The advantages of systemic corticosteroids in the perioperative context have been further supported by previously published trials. However, the impact of dexamethasone on the intensity of post-TKA PPSP is still unclear. We aimed to investigate its effect on the degree of PPSP and compare that with a placebo.</p><p><strong>Methods: </strong>In this randomized, double-blind, placebo-controlled study, 48 patients undergoing unilateral TKA were given intravenous dexamethasone 10 mg or saline just before spinal anesthesia was induced, and they also received two additional doses of dexamethasone 10 mg or saline 24 and 48 h after surgery. A standardized, multimodal analgesic regimen was administered to each patient. The modified WOMAC pain scores at 12 weeks postoperative were the main outcome. The secondary outcomes included pain during a walk of five meters, pain during active knee flexion at 45 degrees, maximum pain at rest during the previous 24 h, nausea visual analogue scale values, and use of rescue opioid and antiemetic medications.</p><p><strong>Results: </strong>There was no difference in modified WOMAC pain scores 12 weeks after surgery between patients who received and did not receive perioperative dexamethasone. At 24, 30, 48, 54, and 72 h following surgery, the dexamethasone group experienced considerably less pain during a five-meter walk and during 45 degrees active knee flexion (p < 0.01). At postoperative 0-24, 24-48, and 48-72 h, the dexamethasone group experienced less maximal pain at rest (p < 0.01). The dexamethasone group also had less visual analogue scale scores for nausea at 6, 24, 30, 48, and 54 h after surgery (p < 0.02). During the first 0-24 and 24-48 h, the dexamethasone group consumed fewer opioids and antiemetic medications (p < 0.01). All patients showed no signs of wound complications.</p><p><strong>Conclusions: </strong>When compared to a placebo at 12 weeks after TKA, intravenous dexamethasone did not reduce PPSP. Nevertheless, early postoperative pain was relieved by perioperative intravenous dexamethasone, which also decreased the need for opioid and antiemetic medications and decreased postoperative nausea and vomiting.</p><p><strong>Trial registration: </strong>NCT02760459.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"19 1","pages":"854"},"PeriodicalIF":2.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11657332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of the position of the femoral endobutton on knee function in the posterior cruciate ligament reconstruction: a retrospective study.","authors":"Libin Xu, Fangyong Lou, Haitao Jiang","doi":"10.1186/s13018-024-05347-x","DOIUrl":"10.1186/s13018-024-05347-x","url":null,"abstract":"<p><strong>Background: </strong>To investigate the effect of the position of the femoral endobutton on knee function in the posterior cruciate ligament reconstruction (PCLR).</p><p><strong>Methods: </strong>A retrospective study was conducted to analyze 96 patients who underwent single-bundle reconstruction of posterior cruciate ligament (PCL) in our hospital from January 2020 to June 2023. The patients were divided into three groups according to the position of the endobutton on the lateral knee radiography. The first group is the position of endobutton in front of the lateral cortex of the femur, the second group is the position of endobutton in back of the lateral cortex of the femur, and the third group is the position of endobutton behind the femur. Knee Lysholm score, International Knee Documentation Committee (IKDC) Evaluation, Tegner Activity Scale, knee flexion angle and postoperative complication rate of the three groups were compared to evaluate whether there were statistical differences among the three groups.</p><p><strong>Results: </strong>There were 39 patients in group 1, 46 patients in group 2, and 11 patients in group 3. The mean Lysholm Knee Scores of the group 1 was 91.77, 92.17 in group 2, and 90.36 in group 3. The mean IKDC Evaluation of group 1 was 90.48, 92.41 in group 2, and 93.00 in group 3. Tegner Activity Level was 5.69 in group 1, 5.72 in group 2, and 5.45 in group 3. The mean flexion degree was found as 125° in patients in group1, 127° in group 2, and 122° in group 3. There was no statistically significant difference between Lysholm Knee Scores (p = 0.434), IKDC (p = 0.068), Tegner Activity Level (p = 0.797), and knee flexion angle (p = 0.135). There was also no significant difference in the incidence of complications among the three groups (p > 0.05).</p><p><strong>Conclusion: </strong>There were not statistically differences in clinical functional results when comparing patients' endobutton location on femur. This indicates that it does not need to adjust the orientation of the exit hole of the femur whether it is forward or backward during the PCLR.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"19 1","pages":"858"},"PeriodicalIF":2.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11657873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CCL4L2 participates in tendinopathy progression by promoting macrophage inflammatory responses: a single-cell analysis.","authors":"Junxiang Xu, Minzhe Zheng, Zongxian Feng, Qiji Lin","doi":"10.1186/s13018-024-05268-9","DOIUrl":"10.1186/s13018-024-05268-9","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Tendinopathy is very common in clinical practice, which is highly prevalent in athletes, sports enthusiasts and other people involved in high-load weight-bearing activities. Common types of tendinopathy include rotator cuff injury, Achilles tendinitis, tennis elbow and so on. Macrophages (Macs) are key immune cells in the pathogenesis of tendinopathy. In this study, CCL4L2&lt;sup&gt;+&lt;/sup&gt; M1-related signaling pathways were screened by combining single-cell RNA sequencing (scRNA-seq) to explore their significance in tendinopathy treatment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Immune cell populations were screened by Uniform Manifold Approximation and Projection (UMAP) downscaling, and Mac cell subsets were annotated using cell marker genes. The cellular communication mechanism between different cellular subsets such as Macs and tendon stem/progenitor cells (TSPCs) was demonstrated by cellular communication analysis. Based on cell marker genes of CCL4L2 + M1, Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were performed to compare the expression differences in M1 and M2 between the Disease and Healthy groups. Associations between CCL4L2&lt;sup&gt;+&lt;/sup&gt; M1 and TSPCs were inferred by cell-cell communication analysis. The effects of CCL4L2 on Mac polarization and TSPCs were verified by enzyme-linked immunosorbent assay (ELISA) and real-time fluorescence quantitative PCR (qPCR).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The proportions of TSPCs, endothelial cells (ECs), smooth muscle cells (SMCs), and immune cells were significantly elevated in the Disease group. The proportion of M1 cells in the Disease group was higher than that in the Healthy group, while the proportion of M2 cells was lower than that in the Healthy group. M1 differentially expressed genes (DEGs) were mainly enriched to disease-related and immunoinflammation-related signaling pathways. Signaling intensities between M1 and TSPCs in pathways related to immunoinflammation and ischemic injury were significantly increased in the Disease group. The proportion of CCL4L2 + M1 in the Disease group was significantly higher than in the Healthy group, and communications between CCL4L2 + M1 and TSPCs varied significantly. Compared with the Control group, the expression levels of inflammatory cytokines were higher in the CCL4L2 group, and the expression levels of tendon differentiation markers (Egr1, Mkx, Scx, Type 1 collagen, Tnmd) were significantly down-regulated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The present study analyzed the heterogeneous alterations in the Healthy and Disease groups by scRNA-seq data and found that there was a significant inflammatory infiltrate in the Disease group with markedly increased Mac activity, which was associated with activation of the CCL4L2 + M1-associated signaling pathways. CCL4L2 promotes M1 polarization and inhibits TSPC differentiation through activating M1-related inflammatory signaling pathways. These findi","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"19 1","pages":"836"},"PeriodicalIF":2.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kinematic status of Bryan and Mobi-C artificial cervical discs post cervical hybrid surgery: a retrospective study.","authors":"Yukun Ma, Yang Xiong, Ting Wang, Xing Yu, Chuanhong Li, Letian Meng, He Zhao, Yongdong Yang, Dingyan Zhao, Fengxian Wang, Yi Qu","doi":"10.1186/s13018-024-05316-4","DOIUrl":"10.1186/s13018-024-05316-4","url":null,"abstract":"<p><strong>Objective: </strong>To examine the mid-term efficacy and imaging results of using the Mobi-C and Bryan implants after cervical hybrid surgery for 2-level cervical spondylolisthesis, and to observe their postoperative changes and differences in the flexion-extension center of rotation (FE-COR) for the anterior cervical disc replacement (ACDR) segment.</p><p><strong>Methods: </strong>Patients who underwent cervical hybrid surgery between June 2014 and June 2019 were included in this study. The mJOA, NDI, and VAS scores were used to assess clinical outcomes, and the FE-COR of the ACDR segment was measured. Pre-operative and 36-month radiographs were collected to compare the range of motion (ROM) in the total cervical spine, ACDR segmental ROM, and operated adjacent segmental ROM. Translation distances for the Mobi-C and Bryan devices were measured. The degree of disc degeneration in the adjacent segment and bony fusion of the ACDF segment were observed.</p><p><strong>Results: </strong>Eighty-one patients were included (40 in the Mobi-C group and 41 in the Bryan group). All patients showed improvements in their postoperative mJOA, NDI, and VAS scores (P < 0.05). The C2-C7 ROM decreased in both groups (P < 0.05). There was no significant decrease in ACDR segmental ROM and upper or lower adjacent segmental ROM compared with preoperatively (P > 0.05). No significant differences were found between the two groups in the above ROM measurements (P > 0.05). For the Mobi-C group, the follow-up compared with pre-surgery showed statistical significance in both FE-COR-X (44.86 ± 7.70% vs. 57.13 ± 8.45%, P < 0.05) and FE-COR-Y (52.29 ± 12.71% vs. 34.47 ± 10.32%, P < 0.05). For the Bryan group, there were no significant differences at follow-up in FE-COR-X and FE-COR-Y compared with pre-surgery (P > 0.05). No significant difference in translation distance between the two groups was observed (P > 0.05). All ACDF segments were in a stable condition. Twenty-two out of 162 adjacent segments showed imaging ASD (9 cases in the Mobi-C group and 13 cases in the Bryan group). In the Mobi-C group, there were mild cases in 6 instances and moderate cases in 3 instances. In the Bryan group, there were mild cases in 8 instances and moderate cases in 5 instances.</p><p><strong>Conclusions: </strong>Cervical hybrid surgery using either the Mobi-C or Bryan artificial cervical discs can achieve satisfactory results. The FE-COR of the Mobi-C segment shifts forward and downward, while the FE-COR of the Bryan segment is relatively closer to the pre-operative condition. Changes in the FE-COR after hybrid surgery in both the Mobi-C and Bryan segments might not affect clinical outcomes.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"19 1","pages":"857"},"PeriodicalIF":2.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11657316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of orthopedic robots in total hip arthroplasty: a network meta-analysis and systematic review.","authors":"Zhenhua Wu, Yin Zheng, Xiwei Zhang","doi":"10.1186/s13018-024-05279-6","DOIUrl":"10.1186/s13018-024-05279-6","url":null,"abstract":"<p><strong>Background: </strong>With the increasing demand for total hip arthroplasty (THA) and the inevitable trend of orthopedic robots and artificial intelligence in the future, it is necessary to explore the safety and effectiveness of orthopedic robots in THA. Currently, most orthopedic robots are in the early stages of development, and evaluating their clinical efficacy can assist in making informed decisions for practical use.</p><p><strong>Objective: </strong>To explore the advantages of 7 types of robot-assisted THA with respect to 5 indicators.</p><p><strong>Methods: </strong>Literature from databases such as CNKI, PubMed, and Web of Science was retrieved up to July 17, 2024. Literature evaluation was conducted via Review Manager 5.4, and a network meta-analysis was performed via RStudio (version 4.4.1).</p><p><strong>Results: </strong>A total of 17 studies involving 1741 patients were included. In direct comparisons, the operation time was longer for MAKO (MD = 19; CI = 6.7, 31), TRex (MD = 37, CI = 20, 54) and YUANHUA (MD = 35, CI = 4.2, 66) than for C-THA. The leg length discrepancy (LLD) was smaller for TRex (MD = -3.4, CI = -6.6, -0.36) and RO (MD = -4.3, CI = -8.7, -0.064) than for C-THA. In the comprehensive best probability ranking, operation time [C-THA (96%) > TJ (68%) > RO (53.2%) > MAKO (53%) > LA (45%) > YU (21%) > TR (13%)], blood loss [TJ (89%) > C-THA (50%) > LA (49%) > YU (42%) > MAKO (20%)], LLD [RO (83%) > TR (75%) > MAKO (61%) > TJ (51%) > YU (43%) > JJ (40%) > C-THA (24%) > LA (22%)], HHS [RO (65%) > C-THA (55%) > LA (51%) > TR (50%) > JJ (48%) > YU (46%) > MAKO (37%)], and infection [TJ (77%) > C-THA (67%) > MAKO (44%) > RO (10%)].</p><p><strong>Conclusion: </strong>Each of the seven types of RA-THA and C-THA has its own advantages, with TJ and RO RA-THA being slightly more prominent. Overall, in terms of safety and effectiveness, RA-THA is generally superior to C-THA, although further development is still needed.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"19 1","pages":"846"},"PeriodicalIF":2.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-articular injection of exosomes derived from different stem cells in animal models of osteoarthritis: a systematic review and meta- analysis.","authors":"Yajie Kong, Yuzhong Wang, Yujia Yang, Yu Hou, Jingjing Yu, Meiling Liu, Siyi Xie, Yongzhou Song","doi":"10.1186/s13018-024-05227-4","DOIUrl":"10.1186/s13018-024-05227-4","url":null,"abstract":"<p><strong>Background: </strong>In recent years, the increasing incidence of osteoarthritis (OA) has attracted widespread public attention; however, the available effective treatments are limited. As a result, new therapeutic approaches, including stem cell and exosome therapies, have been proposed and are gradually gaining popularity. Because exosomes are immunocompatible, there is thought to be more potential for their use in clinical settings. This study summarizes the efficacy of exosomes in the treatment of OA.</p><p><strong>Methods: </strong>In total, we conducted a comprehensive search of the PubMed, Web of Science, and Embase databases using medical subject headings terms to identify studies published from their inception until November 2023 that investigated the use of stem cell-derived exosomes in treating OA. We focused on specific outcomes including osteophyte score, chondrocyte count, pain level, qPCR and histological assessments such as the OARSI (Osteoarthritis research society international) score to measure cartilage degeneration. For data extraction, we used GetData Graph Digitizer to retrieve values from graphs, and the meta-analysis was conducted using RevMan 5.3 software. We chose mean difference (MD) as the primary effect measure since all included studies reported the same outcomes. Ultimately, 20 articles met the inclusion criteria and were included in the meta-analysis.</p><p><strong>Results: </strong>We evaluated 20 studies comprising a total of 400 subjects. Compared with control groups, the exosome-treated groups showed significantly improved histological outcomes, as measured by the OARSI score (n = 400; MD = -3.54; 95% CI = [-4.30, -2.79]; P < 0.00001; I² = 98%). This indicates a marked reduction in cartilage degeneration and OA severity in the exosome-treated groups. Notably, exosome therapy was more effective when administered during the early stages of OA. Additionally, a once-weekly dosing schedule yielded better results compared to more frequent administrations. Of the three exosome isolation methods assessed, kit-based extraction demonstrated a trend toward superior therapeutic efficacy.</p><p><strong>Conclusions: </strong>Exosome treatment improved OA compared to placebo treatment.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"19 1","pages":"834"},"PeriodicalIF":2.8,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with postoperative coronal imbalance in adult patients with severe and rigid scoliosis: a retrospective study.","authors":"Congying Zou, Luming Tao, Lei Zang, Yong Hai","doi":"10.1186/s13018-024-05328-0","DOIUrl":"10.1186/s13018-024-05328-0","url":null,"abstract":"<p><strong>Background: </strong>Extensive studies examined coronal imbalance (CIB) in adolescent and adult degenerative scoliosis; however, few studies addresses on CIB in adult with severe rigid scoliosis (SRS). Therefore, we analyzed postoperative SRS patients to identify factors associated with postoperative CIB.</p><p><strong>Methods: </strong>In this retrospective study, we investigated SRS patients undergoing one-stage posterior column osteotomy (PCO) and fusion at our hospital between August 2012 and January 2019. The preoperative, postoperative and follow-up whole-spine anteroposterior (AP) radiographs were evaluated. Potential risk factors for postoperative CIB were analyzed using the LASSO regression, and independent risk factors were identified using binary logistic regression. A nomogram prediction model was constructed and validated.</p><p><strong>Results: </strong>Ninety eligible SRS patients were included. Postoperative radiographs showed a main curve correction rate of 54.17 ± 14.02%; however, follow-up CIB persisted in 26.67% of patients. Three independent variables affecting follow-up CIB were identified by LASSO regression, including preoperative CIB+ [OR = 12.414 (95% CI: 2.228, 69.162), P = 0.004], major curve flexibility index < 10% [OR = 14.300 (95% CI: 2.200, 92.957), P = 0.005], and immediate postoperative CIB [OR = 5.169 (95% CI: 1.387, 19.263), P = 0.014]. ROC and DCA analysis demonstrated that the nomogram had good predictive performance.</p><p><strong>Conclusions: </strong>Preoperative CIB+, major curve flexibility index < 10%, and immediate postoperative CIB were significantly associated with postoperative CIB. These findings offer valuable guidance to improve surgical outcomes and reduce complications.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"19 1","pages":"833"},"PeriodicalIF":2.8,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}