Journal of Orthopaedic Surgery and Research最新文献

{"title":"Do wrist anatomical differences predispose to scapholunate ligament injury? A case-control radiographic study.","authors":"Ebubekir Eravsar, Ali Gulec, Fatih Bilal Sezer, Ibrahim Ozkan, Ali Özdemir, Mehmet Ali Acar","doi":"10.1186/s13018-025-06296-9","DOIUrl":"10.1186/s13018-025-06296-9","url":null,"abstract":"<p><strong>Purpose: </strong>Scapholunate interosseous ligament (SLIL) injury is the most common cause of carpal instability and may lead to scapholunate advanced collapse if untreated. While several anatomical wrist variations have been implicated in other wrist pathologies, limited studies have explored their role in SLIL injuries. This study aimed to compare specific anatomical parameters on wrist radiographs between patients with arthroscopically confirmed SLIL injuries and healthy individuals to identify potential anatomical predispositions.</p><p><strong>Methods: </strong>This study analyzed bilateral wrist radiographs of 87 patients who underwent arthroscopic dorsal capsulodesis for SLIL injuries between 2010 and 2023. A control group of 87 asymptomatic individuals with normal wrist radiographs was also included. Standardized anteroposterior and lateral wrist X-rays were collaboratively evaluated by three orthopedic surgeons. Parameters measured included radial inclination (RI), lunate fossa inclination (LFI), ulnar variance (UV), lunate tilting angle (LTA), lunate uncovering index (LUCI), carpal height ratio (CHR), palmar tilting angle (PTA), and lunate morphology. Group comparisons were performed, and a multiple logistic regression analysis was conducted using variables found to be significant in univariate analysis to identify independent anatomical predictors of SLIL injury.</p><p><strong>Results: </strong>There were no significant differences between the SLIL-injured patient group and the control group in terms of gender, age, and side (p > 0.05). RI (p < 0.001) and LFI (p = 0.016) were significantly lower, while LTA (p < 0.001) was significantly higher in the SLIL-injured patient group. Multiple logistic regression analysis revealed that lower RI (OR: 0.853, 95% CI: 0.769-0.946; p = 0.003) and higher LTA (OR: 1.126, 95% CI: 1.052-1.204; p = 0.001) were independently associated with SLIL injury. LFI did not remain significant in the final model. No significant differences were observed in UV, LUCI, PTA, CHR, or lunate type between groups.</p><p><strong>Conclusion: </strong>Low RI and increased LTA may represent anatomical risk factors for SLIL injury. Other parameters were not associated with an increased risk of injury. This study was not designed to establish a radiological diagnosis of SLIL injury; rather, it demonstrates that SLIL injuries may be influenced by individual anatomical variations. Further large scale studies are needed to validate these findings and to better understand the anatomical contributions to SLIL injury susceptibility.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"823"},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Shoulder range of motion and strength in beach tennis athletes compared to volleyball and tennis players: implications for injury risk and performance.","authors":"Ana Paula Ramos, Leonardo Luiz Barretti Secchi, Filippo Migliorini, Nicola Maffulli, Rodrigo Okubo","doi":"10.1186/s13018-025-06295-w","DOIUrl":"10.1186/s13018-025-06295-w","url":null,"abstract":"","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"822"},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute medial tibial plateau elevation with gradual metaphyseal correction using an Ilizarov fixator for late-presenting infantile Langenskiold stage V and VI Blount's disease. Short-term results.","authors":"Mohamed Abdelaal Hussein, Mokhtar Ahmed Alsayed, Ali H Al-Yami, Eyad A Alakkas, Raad M M Althaqafi, Ahmed Aljahdali, Gamal Ahmed Hosny, Ahmed A Khalifa","doi":"10.1186/s13018-025-05829-6","DOIUrl":"10.1186/s13018-025-05829-6","url":null,"abstract":"<p><strong>Purpose: </strong>Correcting severe deformities associated with advanced stages of Blount's disease in adolescents varies in the literature between acute and gradual corrections. We aimed to report the early results (radiological and complications) of performing acute medial tibial plateau elevation combined with gradually correcting the metaphyseal deformity using an Illizarov external fixator in adolescents with late-presenting infantile Langenskiold stage V and VI Blount's disease.</p><p><strong>Methods: </strong>A prospective case series of 24 patients (24 limbs) with Langenskiold stage V and VI Blount's disease having a mean age of 11.63 ± 1.74 years were included. The radiological outcomes included hip-knee-ankle (HKA) angle, medial proximal tibial angle (MPTA), joint line convergence angle (JLCA), Posterior proximal tibial angle (PPTA), and medial tibial plateau depression angle (MTPDA). Complications at any time point were reported.</p><p><strong>Results: </strong>The Illizarov frame was removed after a mean of 14 ± 2.04 weeks postoperatively. After a mean follow up of 23.33 ± 9.43 months, all the radiological outcomes improved significantly (< 0.001) compared to preoperative values, HKA: 182.17 ± 1.97 vs. 148.29 ± 9.88, MPTA:88.0 (87.0-90.0) vs. 75.5 (70.0-80.0), PPTA 82.0 ± 1.82 vs. 67.67 ± 5.02, JLCA: 2.46 ± 1.77 vs. 19.92 ± 2.75, and MTPDA: 1.96 ± 2.07 vs. 50.08 ± 7.19. No cases of neurovascular complications. The pin tract infection rate was 62.5%, and all were treated conservatively. Varus deformity recurred in 5 (20.8%) patients, all at the metaphyseal level, with no collapse at the elevated medial tibial plateau. Significant Leg length discrepancy (> 2 cm) was encountered in 6 (25%) patients (five were patients with recurrent varus deformities, where the LLD was compensated after deformity correction).</p><p><strong>Conclusion: </strong>The management protocol we adopted, which entailed acute elevation of the medial tibial plateau depression combined with gradual correction of the proximal tibial deformity assisted by the Illizarov external fixator, provided promising results regarding its safety, ability of full deformity correction, and acceptable recurrence incidence.</p><p><strong>Clinical trial registration: </strong>Not applicable.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"821"},"PeriodicalIF":2.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the clinical efficacy of percutaneous endoscopic lumbar interbody fusion through different surgical approaches: a retrospective study.","authors":"Zijia Feng, Ziqi He, Jianshu Zhu, Changfeng Fu","doi":"10.1186/s13018-025-06265-2","DOIUrl":"10.1186/s13018-025-06265-2","url":null,"abstract":"<p><strong>Background: </strong>This is a retrospective study to compare the clinical efficacy of percutaneous endoscopic posterior lumbar interbody fusion (PE-PLIF), percutaneous endoscopic transforaminal lumbar interbody fusion (PE-TLIF), and trans-articular process percutaneous endoscopic lumbar interbody fusion (trans-AP PELIF).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of patients with lumbar spinal stenosis or lumbar disc herniation who underwent percutaneous endoscopic lumbar interbody fusion (PELIF) through different surgical approaches in our hospital from January 2018 to December 2023.According to the operation method, the patients were divided into PE-PLIF group (n = 24), PE-TLIF group (n = 16) and trans-AP PELIF group (n = 9). The perioperative, follow-up and imaging data of the three groups were compared.</p><p><strong>Results: </strong>All patients in the three groups successfully completed the operation. Compared with the PE-PLIF group, the operation time, intraoperative blood loss and postoperative drainage volume in the PE-TLIF group and the trans-AP PELIF group were significantly reduced (P < 0.05).There was no significant difference in the length of hospital stay, complication rates, and the time to first ambulation among the three groups (P > 0.05). The Visual Analogue Scale for back pain (VAS-B) and leg pain (VAS-L), Japanese Orthopaedic Association (JOA), and Oswestry Disability Index (ODI) scores of the three groups were significantly improved compared with those before operation (P < 0.05). There was no significant difference in the VAS-B, VAS-L, JOA and ODI scores among the three groups before the operation and at the same time points after the operation (P > 0.05).Compared with pre-operation, the disc height (DH) was improved at the last follow-up (P < 0.05).There was no significant difference in lumbar lordosis angle (LLA) between the pre-operation and the last follow-up (P > 0.05). There was no significant difference in these two indicators among the three groups before the operation and at the same time points after the operation (P > 0.05). The fusion rates of the three groups were all 100%, and there was no significant difference in the fusion effect (P > 0.05).</p><p><strong>Conclusions: </strong>The three different approaches of PELIF have good efficacy and similar postoperative recovery effect. Compared with the PE-PLIF, the PE-TLIF and the trans-AP PELIF have the advantages of shorter operation time, less intraoperative bleeding and less postoperative drainage. (Registration number: MR-22-25-033828; date of registration: 2025-04-28; retrospectively registered).</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"820"},"PeriodicalIF":2.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interlimb differences in gait kinematics, kinetics, and muscle activation during walking and running one year after acute unilateral Achilles tendon rupture.","authors":"Kari Huseth, Guðni Rafn Harðarson, Per Aagaard, Annelie Gutke, Roland Zügner, Jón Karlsson, Katarina Nilsson Helander, Elin Larsson, Annelie Brorsson, Roy Tranberg","doi":"10.1186/s13018-025-06221-0","DOIUrl":"10.1186/s13018-025-06221-0","url":null,"abstract":"<p><strong>Background: </strong>Approximately 30% of individuals with Achilles tendon rupture do not fully restore normal gait function, regardless of the treatment chosen. Limited knowledge exists about the long-term kinematic, kinetic, and neuromuscular adaptations after repair of an acute Achilles tendon rupture and their impact on muscle/tendon function. This exploratory cross-sectional study assessed between-limb differences in terms of lower-limb kinematics, kinetics, and muscle activation during walking and jogging stance phases one year after an Achilles tendon rupture.</p><p><strong>Methods: </strong>Thirty-seven participants (29 males, 8 females; mean age 47.4 ± 9.4 years) were included in the study one year after Achilles tendon rupture, who were both operatively and non-operatively treated. Electromyography (EMG) was recorded synchronously with kinematic and kinetic data using an optical motion capture system with a cluster-based marker set allowing six degrees of freedom. Bilateral EMG was collected from the tibialis anterior, medial and lateral gastrocnemius, and soleus muscles. The stance phase was divided into initial contact to mid-stance (IC-MS) and mid-stance to toe-off (MS-TO). Differences between affected and unaffected limbs were analyzed with multivariate normal models, reporting point estimates and 95% credible intervals.</p><p><strong>Results: </strong>During walking, triceps surae activation increased in MS-TO, while running showed greater activation in IC-MS. Affected limbs showed higher lateral gastrocnemius activation during walking IC-MS (2.1 EMG%; CI: 0.5-3.7) as well as greater medial (3.4%; CI: 0.5-6.3) and lateral (4.9%; CI: 2.3-7.6) activation in MS-TO. Ankle sagittal joint excursion was reduced in walking MS-TO (-1.8°; CI: -2.8 to - -0.8) and running MS-TO (-4.1°; CI: -5.8 to -3.5), with decreased sagittal plantarflexor moments during running (0.06 Nm/kg: CI: 0.01-0.11).</p><p><strong>Conclusion: </strong>One year after Achilles tendon rupture, walking was characterized by increased gastrocnemius muscle activation and reduced ankle sagittal joint excursion compared with the unaffected side. Moreover, running also showed reduced ankle joint excursion accompanied by attenuated plantar flexor moments, however, without any evident side-to-side differences in EMG recordings. Despite the observed inter-limb deficits, gait resembled normative kinematic patterns, likely reflecting compensatory mechanisms. EMG and joint moments were more variable than kinematics. These results support the need for individualized targeted long-term triceps surae rehabilitation following Achilles tendon rupture.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"819"},"PeriodicalIF":2.8,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Effectiveness of anabolic and anti-resorptive agents for preventing postmenopausal osteoporosis fractures: a systematic review and network meta-analysis.","authors":"Peng Su, Maofu Li, Jian Xiao, Longbin Bai","doi":"10.1186/s13018-025-06255-4","DOIUrl":"10.1186/s13018-025-06255-4","url":null,"abstract":"","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"818"},"PeriodicalIF":2.8,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haptic-visual evaluation of the J-Sign revealed a significant correlation with patella height, tibial tubercle - trochlear groove distance, trochlear bump height and the total number of risk factors for lateral patellar instability.","authors":"Felix Zimmermann, Eric Mandelka, Jula Gierse, Sven Y Vetter, Paul Alfred Grützner, Peter Balcarek","doi":"10.1186/s13018-025-05946-2","DOIUrl":"10.1186/s13018-025-05946-2","url":null,"abstract":"","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"817"},"PeriodicalIF":2.8,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"More than pain and physical limitation: the declined cognitive performance associated with rotator cuff injuries.","authors":"Poyu Chen, Chih-Hao Chiu, Po-Tsun Chen","doi":"10.1186/s13018-025-06180-6","DOIUrl":"10.1186/s13018-025-06180-6","url":null,"abstract":"<p><strong>Background: </strong>Rotator cuff (RC) injuries often lead to shoulder pain, physical limitations, sleep disturbances, and emotional distress. However, the relationship between these symptoms and cognitive decline remains unclear.</p><p><strong>Methods: </strong>We recruited 150 patients with RC injury, who completed the Visual Analog Scale (VAS) for pain, the American Shoulder and Elbow Surgeons scale (ASES), the Pittsburgh Sleep Quality Index (PSQI), the Beck Depression Inventory II (BDI-II), and the State-Trait Anxiety Inventory (STAI). Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), Digit Symbol Substitution Test (DSST), Trail Making Test (TMT), and Digit Span.</p><p><strong>Results: </strong>High prevalence rates of potential MCI (54% based on MoCA) and sleep disturbance (64.7%) were found. Depressive and anxiety symptoms were present in 18% and 28-30%, respectively. Multiple regressions indicated that older age, lower education, poorer sleep quality, and higher state anxiety were significant predictors across various cognitive tests, but not the pain intensity. Instead, logistic regression confirmed that older age (OR = 1.08, 95% CI: 1.04-1.12) and lower shoulder function (OR = 0.97, 95% CI: 0.95-0.99) significantly increased MCI risk.</p><p><strong>Discussion: </strong>This study highlights that while pain intensity itself was not a predictor of cognitive decline, other associated symptoms like sleep disturbances and emotional distress contribute to poor cognitive function. Furthermore, the physical limitations resulting from RC injuries increase the risk of mild cognitive impairment (MCI). Management of RC injuries should thus address cognitive factors alongside physical and psychological symptoms.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"816"},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-cultural adaptation and validation of the Chinese version of American orthopaedic foot and ankle society hallux metatarsophalangeal-interphalangeal scale (AOFAS-Hallux-MTP-IP) in patients with hallux valgus.","authors":"Qiong Wang, Jin Tong, Jiabao Liang, Dongdong Ji, Zhe Wang, Jingqi Liang, Hongmou Zhao","doi":"10.1186/s13018-025-06196-y","DOIUrl":"10.1186/s13018-025-06196-y","url":null,"abstract":"<p><strong>Background: </strong>Hallux valgus (HV) is a common deformity of the hallux, which affects the functional ability of patients and reduces their quality of life. The American Orthopaedic Foot and Ankle Society (AOFAS) Hallux Metatarsophalangeal (MTP)-Interphalangeal (IP) scale is a questionnaire widely used to comprehensively assess the condition of hallux deformities. The purpose of this study was to translate the AOFAS-MTP-IP scale into a Chinese version (AOFAS-MTP-IP-CV), conduct cross-cultural adaptation, and simultaneously evaluate its validity and reliability.</p><p><strong>Methods: </strong>Translate the AOFAS-Hallux-MTP-IP-CV according to general guidelines and conduct cross-cultural adaptation for it. From November 2024 to June 2025, a total of 120 patients with HV deformity who could communicate in Chinese were included. They successfully completed the demographic questionnaire, the Manchester-Oxford Foot Questionnaire-Chinese version (MOXFQ-CV), and the EuroQoL Group's five‑dimension questionnaire (EQ‑5D). The reliability of AOFAS-Hallux-MTP-IP-CV was determined by internal consistency, inter-rater reliability, intra-rater reliability, and test-retest reliability. Two orthopedic surgeons were responsible for the collection of questionnaires. The intra-rater reliability and inter-rater reliability were evaluated by the intraclass correlation coefficient (ICC). The internal consistency of the scale items was assessed by calculating the Cronbach's alpha coefficient. The Bland-Altman analysis was used to test the consistency between test-retest assessments. The construct validity of AOFAS-Hallux-MTP-IP-CV was determined by MOXFQ-CV and EQ-5D. Floor/ceiling effects were analyzed to assess scale responsiveness, with < 15% of scores at floor/ceiling levels indicating adequate range.</p><p><strong>Results: </strong>The AOFAS-Hallux-MTP-IP-CV was well accepted with no ceiling or floor effect. The intra-rater reliabilities of the total score of the AOFAS-Hallux-MTP-IP-CV and the pain, function, and alignment dimensions were 0.941, 0.925, 0.945, and 0.922, respectively. The inter-rater reliabilities were 0.916, 0.877, 0.885, and 0.896, respectively. The Bland-Altman plots showed good consistency in test-retest measurements. The total score of AOFAS-Hallux-MTP-IP-CV showed moderate to strong correlations with the pain dimension (r = -0.676) and the walking/standing dimension (r = -0.757) of the MOXFQ and the EQ-5D (r = -0.601).</p><p><strong>Conclusion: </strong>The AOFAS-Hallux-MTP-IP-CV has good feasibility, reliability and validity. It can be recommended for the comprehensive assessment of the clinical conditions of patients with hallux valgus (HV) deformity in Mainland China.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"814"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a novel rabbit model of angular kyphosis and characterization of its neuropathological features.","authors":"Xueneng Yang, Huaiquan Gu, Ruijuan Li, Bo Li, Liming Guo, Jun Shu","doi":"10.1186/s13018-025-06220-1","DOIUrl":"10.1186/s13018-025-06220-1","url":null,"abstract":"<p><strong>Background: </strong>Angular kyphosis, often resulting from congenital anomalies, trauma, infections, or tumors, can cause severe spinal cord compression, ischemia, and neurological dysfunction. Due to its sharp curvature and complexity, angular kyphosis remains challenging to treat surgically. This study aimed to establish a rabbit model to mimic the progression of angular kyphosis and its neurological consequences.</p><p><strong>Methods: </strong>Fifty-six New Zealand white rabbits were divided into four groups: Group A (sham), and Groups B-D (2, 4, and 8 weeks postoperative, respectively). Angular kyphosis was induced via a V-shaped osteotomy between the L2 and L3 vertebrae. Motor function was assessed using Basso-Beattie-Bresnahan Locomotor Rating Scale(BBB scores). Radiological evaluations included Cobb angle and spinal canal occupancy. Histological and apoptosis analyses were conducted to evaluate spinal cord damage.</p><p><strong>Results: </strong>The induced model reliably produced progressive kyphosis with worsening neurological function. BBB scores declined over time, while Cobb angles and canal occupancy rates increased significantly. Histological examination revealed spinal cord ischemia and increased neuronal apoptosis, aligning with observed motor deficits.</p><p><strong>Conclusion: </strong>This rabbit model effectively replicates the clinical features of angular kyphosis, including progressive spinal cord compression and neurological impairment. It provides a reliable platform for investigating the pathophysiology of spinal deformities and evaluating therapeutic interventions.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"815"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}