Journal of Orthopaedic Surgery and Research最新文献

{"title":"Bioelectronic osteosynthesis plate to monitor the fracture bone healing using electric capacitive variations.","authors":"Diogo G Pires, Nuno M Silva, A Completo, Marco P Soares Dos Santos","doi":"10.1186/s13018-025-05534-4","DOIUrl":"10.1186/s13018-025-05534-4","url":null,"abstract":"<p><strong>Background: </strong>Bone fractures represent a global public health issue. Over the past few decades, a sustained increase in the number of incidents and prevalent cases have been reported, as well as in the years lived with disability. Current monitoring techniques predominantly rely on imaging methods, which can result in subjective assessments, and expose patients to unnecessary cumulative doses of radiation. Besides, they are costly and incapable of providing continuous daily detection of fracture healing stages. Technological advances are still required to design fixation systems with the ability to minimize the risk of delayed healing and nonunion conditions for timely medical intervention, such that preventive procedures can be provided. This work proposes.</p><p><strong>Methods: </strong>An innovative bioelectronic osteosynthesis plate, minimally customized from a fixation device used in clinical practice, was developed to monitor the bone-implant interface to effectively detect the progression of bone fractures stages. Our technology includes a network-architectured capacitive interdigitated system, a Bluetooth module, an analog-to-digital converter, a multiplexer, a microcontroller, and a miniaturized battery.</p><p><strong>Results: </strong>Both experimental tests with biological tissues and numerical simulations show strong evidence that this bioelectronic implant is able: (i) to detect the four distinct bone healing stages, with capacitance decreases throughout the healing process; and (ii) to monitor the callus formation across multiple target regions.</p><p><strong>Conclusions: </strong>This work provides a significant contribution to the design of bioelectronic implant technologies for highly personalized sensing of biointerfaces. Our bioelectronic fixation implant supports faster fracture healing, mainly for delayed healing and non-union conditions.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"105"},"PeriodicalIF":2.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomal miR-122 derived from M2 macrophages induces osteogenic differentiation of bone marrow mesenchymal stem cells in the treatment of alcoholic osteonecrosis of the femoral head.","authors":"Guoping Le, Riyou Wen, Huaixi Fang, Zhifa Huang, Yong Wang, Hanwen Luo","doi":"10.1186/s13018-025-05515-7","DOIUrl":"10.1186/s13018-025-05515-7","url":null,"abstract":"<p><p>Alcoholic osteonecrosis of the femoral head (AIONFH) is caused by long-term heavy drinking, which leads to abnormal alcohol and lipid metabolism, resulting in femoral head tissue damage, and then pathological necrosis of femoral head tissue. If not treated in time in clinical practice, it will seriously affect the quality of life of patients and even require hip replacement to treat alcoholic femoral head necrosis. This study will confirm whether M2 macrophage exosome (M2-Exo) miR-122 mediates alcohol-induced BMSCs osteogenic differentiation, ultimately leading to the inhibition of femoral head necrosis. M2 macrophages were identified by flow cytometry, and the isolated exosomes were characterized by transmission electron microscopy (TEM) and Nanoparticle Tracking Analysis (NTA). Next, miR-122 was overexpressed by transfecting miR-122 mimic, and the expression of miR-122 in M2 macrophages and their exosomes was evaluated. Subsequently, the effect of exosomal miR-122 on the osteogenic differentiation ability of BMSCs was detected, including cell proliferation, expression of osteogenic-related genes (RUNX2, BMP2, OPN, ALP), and calcium nodule formation. Finally, the therapeutic effect of M2-Exo was analyzed in a rat model of AIONFH, and bone repair and pathological damage were evaluated by Micro-CT, RT-qPCR, HE, Masson staining, and immunohistochemistry (COL I). The results showed that M2 macrophages were successfully polarized, with an average M2-Exo particle size of 156.4 nm and a concentration of 3.2E + 12 particles/mL. The expression of miR-122 in M2 macrophages is significantly higher than that in M0 macrophages, and miR-122 mimic can increase the content of miR-122 in M2-Exo. miR-122 in M2-Exo can promote osteogenic differentiation of rat bone marrow BMSCs, enhance cell viability, and increase the expression of osteogenesis-related genes. After being applied to the AIONFH rat model, the injection of M2-exo and miR-122 mimics significantly improved the repair effect of articular cartilage, alleviated pathological changes, and promoted the regeneration of bone tissue. M2-macrophage-derived exosomal miR-122 induces osteogenic differentiation of bone mesenchymal stem cells in treating AIONFH.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"107"},"PeriodicalIF":2.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of serum and local GRP78 and CHOP expressions with disease progression in patients with non-traumatic osteonecrosis of femoral head.","authors":"Peng Zhang, Qing-He Ye, Wen-Xiu Zhu, Yong-Heng Zhao, Hong-Xun Zhu, Biao-Fang Wei","doi":"10.1186/s13018-025-05541-5","DOIUrl":"10.1186/s13018-025-05541-5","url":null,"abstract":"<p><strong>Background: </strong>The endoplasmic reticulum stress (ER stress) has been involved in various musculoskeletal disorders including non-traumatic osteonecrosis of femoral head (NT-ONFH).</p><p><strong>Objective: </strong>The current study aimed to investigate the association of glucose-regulated protein 78 (GRP78) as well as CCAAT/enhancer-binding protein homologous protein (CHOP) expressions in serum and femoral head (FH) tissues with NT-ONFH's severity.</p><p><strong>Methods: </strong>We enrolled NT-ONFH patients (n = 150) alongside healthy controls (HCs, n = 150). Meanwhile, 49 patients with femoral neck fracture (FNF) were also enrolled. Serum CHOP and GRP78 levels were determined through enzyme linked immunosorbent assay (ELISA). Local CHOP and GRP78 expressions were detected by immunohistochemistry, western blot, alongside real-time polymerase chain reaction (RT-PCR). Radiographic severity was assessed by FICAT grading system. The visual analogue scale (VAS) together with Harris hip score (HHS) were utilized to determine symptomatic severity.</p><p><strong>Results: </strong>Serum CHOP and GRP78 levels were markedly increased in NT-ONFH patients than HCs. NT-ONFH patients at FICAT stage 4 showed significant higher serum CHOP and GRP78 levels in contrast with those at stage 3. Furthermore, patients at stage 3 demonstrated higher serum CHOP and GRP78 levels than those at stage 2. There was a positive correlation observed between the serum CHOP and GRP78 levels and the severity of the FICAT stages. A total of 42 ONFH patients at FICAT stage 3, 40 patients at FICAT stage 4, and 49 FNF patients received total hip replacement (THR). The mRNA and protein levels of CHOP and GRP78 were elevated in necrotic area compared to the non-necrotic area of ONFH patients and the FH tissues of FNF patients with statistical significance. The expression levels of CHOP and GRP78 within the local tissues were significantly elevated in patients at FICAT stage 4 as opposed to those at stage 3. Besides, ROC curve analysis indicated that serum and local CHOP and GRP78 expressions may act as indicators of disease progression. The levels of CHOP and GRP78, both in serum and at the local site, were in a positive correlation with VAS scores but an inverse relationship with HHS.</p><p><strong>Conclusions: </strong>Serum and local GRP78 as well as CHOP expressions were positively linked with disease progression in NT-ONFH patients. Potential therapeutics targeting ER stress related protein may serve as a method for alleviating NT-ONFH.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"108"},"PeriodicalIF":2.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periprosthetic femoral fractures in minimally-invasive anterolateral short stem versus transgluteal straight stem cementless total hip arthroplasty: What are the differences in the femoral and pelvic morphology?","authors":"Matthias Luger, Sandra Feldler, Manuel Gahleitner, Lorenz Pisecky, Tobias Gotterbarm, Christian Stadler","doi":"10.1186/s13018-025-05502-y","DOIUrl":"10.1186/s13018-025-05502-y","url":null,"abstract":"<p><strong>Background: </strong>The occurrence of periprosthetic femoral fractures (PFFs) in cementless total hip arthroplasty (THA) might be associated with the proximal femoral morphology and the pelvis. PFFs in short stem THA are associated with an increased Canal Flare Index. PFFs in straight stem THA show a decreased Canal Flare Index. Therefore, this study aims to compare the femoral and pelvic geometry in PFFs between short stem and straight stem THA.</p><p><strong>Methods: </strong>A retrospective comparative propensity-score matched study was performed. An institutional database of 5358 THAs was screened for early PFFs within the first 90 days after surgery. All cases of 136 PFFs in primary cementless THA were collected and matched, resulting in 67 PFFs in the straight stem and 37 PFFs in the short stem group. Both groups were analyzed regarding several parameters for femoral and pelvic morphology.</p><p><strong>Results: </strong>A significantly lower distance from the anterior superior iliac spine to the greater trochanter (AGT) was detected in the straight stem group (96.4 vs. 104.8 mm, p = 0.024). All other femoral and pelvic parameters did not differ between both groups. Postoperative Vancouver A PFFs were significantly higher in straight stem THA, while postoperative Vancouver B PFFs were significantly higher in short stem THA.</p><p><strong>Conclusion: </strong>The morphology of the proximal femur and the pelvis do not differ in several radiological parameters in patients sustaining a PFF between cementless short stem implanted via an anterolateral approach and straight stem THA implanted via a transgluteal approach. While there are differences in the Vancouver types of PFFs, these differences do not reflect any difference in the morphology of the proximal femur and the pelvis.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"110"},"PeriodicalIF":2.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling new therapeutic horizons in rheumatoid arthritis: an In-depth exploration of circular RNAs derived from plasma exosomes.","authors":"Guoqing Li, Hongyi Chen, Jiacheng Shen, Yimin Ding, Jingqiong Chen, Yongbin Zhang, Mingrui Tang, Nan Xu, Yuxuan Fang","doi":"10.1186/s13018-025-05494-9","DOIUrl":"10.1186/s13018-025-05494-9","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA), a chronic inflammatory joint disease causing permanent disability, involves exosomes, nanosized mammalian extracellular particles. Circular RNA (circRNA) serves as a biomarker in RA blood samples. This research screened differentially expressed circRNAs in RA patient plasma exosomes for novel diagnostic biomarkers. In this study, samples of RA patients with insufficient response to methotrexate (MTX-IR), combined use of tumor necrosis factor inhibitors (TNFi) were followed up for half a year, and 56 circRNA samples of self-test data were stratified into training, testing, and external validation cohorts according to whether American College of Rheumatology 20% improvement criteria (ACR20) was achieved. A diagnostic xgboost model was developed using common hub genes identified by random forest and least absolute shrinkage and selection operator (LASSO), with intersection genes derived from overlapping machine learning-selected genes. Diagnostic performance evaluated via receiver operating characteristic (ROC) curves using pROC for area under the curve (AUC). Optimal LASSO model with 4 circRNAs determined, with AUC > 0.6 for key genes. The model validation performed well on the test set, but not significantly on the validation set. Then, circRNA screening was performed in combination with clinical data, and cross-validation identified hsa-circ0002715, hsa-circ0001946, hsa-circ0000836, and rheumatoid factor (RF) as key genes, among which hsa-circ0002715 and hsa-circ0001946 were emphasized as key markers on the training set. In addition, the morphology and size of exosomes and the expression of CD9 and CD81 verified the successful extraction of exosomes. The qPCR analysis of plasma exosomes in TNFi patients found that the expression of hsa-circ0002715 was higher than that in patients who didn't reach ACR20, and the expression of hsa-circ0001946 was lower than that in patients who didn't reach ACR20. The above studies suggested that hsa-circ0002715 and hsa-circ0001946 may become markers for predicting MTX-IR RA patients and TNFi precision treatment.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"109"},"PeriodicalIF":2.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of the Arabic version of the Forgotten Joint Score usage in total hip arthroplasty.","authors":"Waleed Albishi, Nasser M AbuDujain, Orfan Arafah, Ibrahim S Alshaygy, Abdulaziz Almaawi, Zyad A Aldosari, Mohammed N Alhuqbani, Omar A Aldosari, Saad M Alangari","doi":"10.1186/s13018-025-05532-6","DOIUrl":"10.1186/s13018-025-05532-6","url":null,"abstract":"<p><strong>Background: </strong>The ultimate goal of arthroplasty is thought to be the ability to \"forget\" a joint implant in daily activities. The Forgotten Joint Score (FJS-12), a score system that evaluates how much patients have been able to forget their hip or knee prosthesis, was recently published. It is based on a self-administered questionnaire that consists of 12 items. The major goal of the current study was to validate, adapt, and evaluate a Arabic-language FJS-12 (Ar-FJS-12) version in patients who had undergone total hip replacement (THA).</p><p><strong>Materials and methods: </strong>The study included 107 patients who underwent THA 1-5 years ago and completed the Ar-FJS. The construct validity of the study was evaluated using the reduced Western Ontario and McMaster Universities Osteoarthritis Index (rWOMAC). To assess the test-retest reliability, 72 people took the Ar-FJS test twice.</p><p><strong>Results: </strong>Cronbach's alpha (Internal Consistency) of the Ar-FJS-12 was 0.957 and the intraclass correlation coefficient (ICC) was 0.931 indicating high reliability. For construct validity, there was a moderate significant correlation between the Arabic the rWOMAC with r = 0.595. The ceiling effect was 1.9% (n = 2), whereas the floor effect was 1.9% (n = 2).</p><p><strong>Conclusion: </strong>The Arabic version of the FJS-12 valid, reliable tool and can be recommended for patients in Arabic-speaking communities who have undergone hip arthroplasty.</p><p><strong>Level of evidence: </strong>III, validity and reliability study.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"104"},"PeriodicalIF":2.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safe distances for transforaminal posterior lumbar interbody fusion under one-hole split endoscopy: three-dimensional reconstruction measurement of 1-degree degenerative lumbar spondylolisthesis at the L_4/5 segment.","authors":"Changzhen Liu, Jiabin Ren, Zhaozhong Sun, Sa Li, Zhimeng Feng, Yuefei Li","doi":"10.1186/s13018-025-05474-z","DOIUrl":"10.1186/s13018-025-05474-z","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;One-hole split endoscopy (OSE) is a novel endoscopic technique that offers some advantages in spinal surgery. However, without a clear understanding of the safe zone for OSE, surgeons risk injuring nerve roots during the procedure. This study aimed to measure the safe distances among critical bone markers, the intervertebral space and nerve roots between 1-degree degenerative lumbar spondylolisthesis (DLS) and non-DLS at the L&lt;sub&gt;4/5&lt;/sub&gt; segment in patients via three-dimensional reconstruction and to compare the differences in relevant safety distances between the two groups. These findings provide a theoretical reference for the safe application of the OSE technique in transforaminal posterior lumbar interbody fusion (TPLIF).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The CT data of 56 patients were obtained, including 30 patients with 1-degree DLS at the L&lt;sub&gt;4/5&lt;/sub&gt; segment (DLS group) and 26 patients with non-DLS (non-DLS group). The bone markers were determined in a three-dimensional model. The relevant distances were as follows: (1) Vertical distance (VD): inferior articular process tip (IAPT) to the upper margin of the intervertebral space (VD&lt;sub&gt;1&lt;/sub&gt;); superior articular process tip and the highest point of the mammillary process (HPMP) to the lower margin of the intervertebral space (VD&lt;sub&gt;2&lt;/sub&gt;, VD&lt;sub&gt;3&lt;/sub&gt;). (2) Horizontal distance (HD): the lateral boundary to the medial boundary at the upper margin of the intervertebral space (HD&lt;sub&gt;1&lt;/sub&gt;) and at the lower margin of the intervertebral space (HD&lt;sub&gt;2&lt;/sub&gt;); the medial margin of the articular surface in the coronal position of the superior articular process to the medial boundary at the lower margin of the intervertebral space (HD&lt;sub&gt;3&lt;/sub&gt;); and the HPMP to the lateral boundary at the upper margin of the intervertebral space (HD&lt;sub&gt;4&lt;/sub&gt;) and at the lower margin of the intervertebral space (HD&lt;sub&gt;5&lt;/sub&gt;).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In the DLS group and non-DLS group, the VD&lt;sub&gt;1&lt;/sub&gt; were (10.97 ± 2.15) mm and (11.32 ± 1.70) mm, the VD&lt;sub&gt;2&lt;/sub&gt; were (11.06 ± 1.75) mm and (10.96 ± 0.91) mm, the VD&lt;sub&gt;3&lt;/sub&gt; were (4.76 ± 1.54) mm and (5.01 ± 1.02) mm, the HD&lt;sub&gt;1&lt;/sub&gt; were (10.54 ± 1.49) mm and (10.97 ± 1.06) mm, the HD&lt;sub&gt;2&lt;/sub&gt; were (17.43 ± 2.01) mm and (17.32 ± 1.70) mm, and the HD&lt;sub&gt;3&lt;/sub&gt; were (2.21 ± 0.99) mm and (2.11 ± 1.33) mm. These measurement distances were not significantly different between the two groups. While HD&lt;sub&gt;4&lt;/sub&gt; (4.17 ± 1.41) mm in the DLS group was significantly greater than HD&lt;sub&gt;4&lt;/sub&gt; (3.29 ± 1.78) mm in the non-DLS group, HD&lt;sub&gt;5&lt;/sub&gt; (1.89 ± 0.93) mm in the DLS group was significantly lower than HD&lt;sub&gt;5&lt;/sub&gt; (2.63 ± 1.45) mm in the non-DLS group (P &lt; 0.05). There was no significant difference between VD&lt;sub&gt;1&lt;/sub&gt; and VD&lt;sub&gt;2&lt;/sub&gt; in the DLS group.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Bone markers represent a novel positioning method for the treatment of 1-degree L&lt;sub&gt;4/5&lt;/sub","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"103"},"PeriodicalIF":2.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mid- to long-term clinical outcomes of modified technique skip-level titanium plate fixation in cervical laminoplasty compared to continuous fixation.","authors":"Shuo Feng, QiRui Zhu, Yang Sun, ZiYao Ding, Zhe Zhuang, Heng-Heng Yu, Ma-Ji Sun, Feng Yuan","doi":"10.1186/s13018-025-05491-y","DOIUrl":"10.1186/s13018-025-05491-y","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the efficacy and safety of skip titanium plates combined with adjacent spinous process suture suspension versus continuous titanium plate fixation in cervical laminoplasty.</p><p><strong>Methods: </strong>A retrospective analysis of 125 patients (62 men, 63 women, average age 60.9 ± 10.4 years) with multilevel cervical spondylotic myelopathy who had cervical laminoplasty with Arch titanium plate fixation from January 2012 to March 2024 in our hospital was done. Patients were stratified into two cohorts based on the fixation technique: Group A (n = 64): Modified technique of skip-level titanium plate fixation (Arch titanium plates at C4 and C6 levels combined with adjacent spinous process suture suspension)Group B (n = 61): Continuous plating (Arch titanium plates applied sequentially from C3 to C7).The comparative analysis focused on perioperative parameters (operative duration, intraoperative blood loss, length of hospital stay), economic factors (hospital costs), and various clinical indicators.</p><p><strong>Results: </strong>The average follow up period was (73.0 ± 38.4) months. Both groups showed no significant differences in gender, age, and disease duration (P > 0.05). Group A had lower hospitalization costs, intraoperative blood loss, operation time, and postoperative hospital stay compared to Group B (P < 0.05). Postoperatively, both groups had significant improvements in JOA scores and NDI (P < 0.005), but there were no significant differences in postoperative scores and improvement rates between the two groups (P > 0.05). At 3 months postoperatively and at the last follow-up, the C2-7 Cobb angle and cervical curvature index decreased compared to preoperative values (P < 0.05), with a significant difference in the C2-7 Cobb angle at the last follow-up (P < 0.05). The sagittal diameter of the spinal canal from C3 to C7 significantly increased (P < 0.05), but there were no significant differences in the improvement of C3, C5, and C7 between the two groups (P > 0.05). At 3 months postoperatively, the opening angles of the C4 and C6 laminae in Group A were smaller than those in Group B (P < 0.05), but there were no significant differences at the last follow-up (P > 0.05). The healing of the C4 and C6 laminae in Group B was superior to that in Group A (P < 0.05), but there were no differences in healing at the last follow-up (P > 0.05). The incidence of axial symptoms was similar (10.9% in Group A and 14.8% in Group B, P = 0.523).</p><p><strong>Conclusions: </strong>During C3-7 laminoplasty, the clinical efficacy of the method combining mini titanium plate fixation (at C4 and C6) with suture fixation is comparable to that of continuous fixation. Moreover, it has an advantage in cost control.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"100"},"PeriodicalIF":2.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-208a-3p discriminates osteoporosis, predicts fracture, and regulates osteoclast activation through targeting STC1.","authors":"Hongbing Qian, Fei Jia, Huiling Qin","doi":"10.1186/s13018-025-05512-w","DOIUrl":"10.1186/s13018-025-05512-w","url":null,"abstract":"<p><strong>Background: </strong>Osteoporosis (OP) frequently occurs in post-menopausal women, increasing the risk of fracture. Early screening OP could improve the prevention of fractures.This study focused on the significance of miR-208a-3p in diagnosing OP and development regulation, aiming to explore a novel biomarker and therapeutic target for OP.</p><p><strong>Methods: </strong>The study enrolled a total of 154 post-menopausal women and grouping was performed based on the incidence of OP and fracture. The significance of miR-208a-3p was evaluated from the perspectives of menopausal correlation, OP diagnosis, and fracture prediction. In mechanism, the regulatory effect and mechanism of miR-208a-3p on osteoclast activation was investigated.</p><p><strong>Results: </strong>miR-208a-3p was menopause-related showing a negative correlation with E₂ and positive correlations with FSH and LH. Significant upregulation of miR-208a-3p was observed in post-menopausal women with OP and showed significant diagnostic potential. Increasing miR-208a-3p was positively correlated with bone metabolism markers and negatively correlated with BMD of post-menopausal women with OP. Moreover, miR-208a-3p was also identified as a risk factor for fracture. STC1 was identified as a direct target of miR-208a-3p and was negatively regulated by miR-208a-3p. Silencing miR-208a-3p significantly alleviated macrophage inflammation and osteoblast activation, which was reversed by the knockdown of STC1.</p><p><strong>Conclusion: </strong>Serum miR-208a-3p served as a diagnostic biomarker for OP and a risk factor for fracture in post-menopausal women. miR-208a-3p regulated macrophage inflammation and further mediated osteoclast activation via targeting STC1.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"98"},"PeriodicalIF":2.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spacer-type tibial osteotomy versus open wedge high tibial osteotomy and unicompartmental knee arthroplasty for Kellgren-Lawrence grade 3-4 medial unicompartmental knee osteoarthritis in patients younger than 65 years.","authors":"Yi Zhang, Xiangzhi Yin, Jinli Chen, Yingze Zhang, Tengbo Yu","doi":"10.1186/s13018-025-05533-5","DOIUrl":"10.1186/s13018-025-05533-5","url":null,"abstract":"<p><strong>Background: </strong>Spacer-type tibial osteotomy have been proven a novel and effective osteotomy to treat osteoarthritis, while lack of comparison with other surgical methods in younger patients. This study aims to evaluate the short-term clinical outcomes of spacer-type tibial osteotomy versus open wedge high tibial osteotomy (OWHTO) and unicompartmental knee arthroplasty (UKA) for Kellgren-Lawrence (K-L) grade 3-4 osteoarthritis (OA) in patients younger than 65 years.</p><p><strong>Methods: </strong>This retrospective study analyzed a total of 224 patients with K-L grade 3-4 knee OA treated from March 2018 to November 2020. Three groups were created according to the operation type. The clinical outcomes recorded preoperatively and at 6, 12 and 24 months postoperatively were the range of motion (ROM), visual analogue scale (VAS), American Knee Society Score (KSS), Western Ontario and McMaster Universities Global (WOMAC) score, operation time, length of incision, relevant complications and failures. Radiographic parameters were measured to evaluate the correction of varus deformity.</p><p><strong>Results: </strong>The cohort comprised 224 patients; 70 underwent spacer-type tibial osteotomy, 73 underwent OWHTO, and 81 underwent UKA. The spacer group had the shortest incision (P = 0.000), least amount of bleeding (P = 0.000), and shortest operation time (P = 0.000). UKA achieved the most significant pain relief based on VAS (P = 0.014), KSS pain score (0.030), and WOMAC score (P = 0.000) at 6 months postoperatively, but there were no differences between three groups at 12 and 24 months postoperatively. The spacer and OWHTO groups achieved significantly greater ROM changes compared with the UKA group (all P = 0.000). The complication rate did not significantly differ between the three groups. No surgical failures were identified in HTO but two spacer dislocations in spacer group and three polyethylene dislocations in UKA.</p><p><strong>Conclusion: </strong>For younger patients with K-L grade 3-4 OA, OWHTO seems to be the most appropriate method through clinical comparisons. Although spacer-type tibial osteotomy offers shorter operation time and comparable clinical outcomes, it also has extended recovery phase, additional fibular incision and the risk of spacer dislocation, which did not appear to be superior to OWHTO and UKA under the indications outlined in this study.</p><p><strong>Trial registration: </strong>Retrospectively registered, QYFY WZLL 27,021.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"99"},"PeriodicalIF":2.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}