Journal of Orthopaedic Surgery and Research最新文献

{"title":"The addition of vitamin E could reduce femoral head penetration of the polyethylene liners.","authors":"Fanxiao Liu, Ling Gao, Dawei Wang, Qingyu Zhang","doi":"10.1186/s13018-024-05402-7","DOIUrl":"10.1186/s13018-024-05402-7","url":null,"abstract":"<p><strong>Background: </strong>Vitamin E-diffused highly cross-linked polyethylene (HXLPE/Vit E) is a relatively advanced material used in total hip arthroplasty (THA) but whether it shows superiority is unclear.</p><p><strong>Objective: </strong>This meta-analysis was performed to investigate the effect of HXLPE/Vit E liners in THA.</p><p><strong>Methods: </strong>Medline/PubMed, Embase and Cochrane Library databases were searched to retrieve studies assessing the efficacy of HXLPE/Vit E liners in THA with the design of a randomized, controlled trial. Meta-analyses were conducted to merge the outcome estimates of interest, such as the femoral head penetration (FHP), FHP rate, FHP in x- (medial/lateral), y- (vertical) and z- (anteroposterior) axes, cup inclination angle, Harris hip score (HHS), numeric rating scale (NRS) and complications. Then pooled outcomes at different time points during the follow-up period were calculated.</p><p><strong>Results: </strong>Follow an elaborate search of related databases, 23 studies involving a total of 54,920 participants were deemed eligible for this meta-analysis. The pooled results revealed significant decreased FHP at the last follow-up (pooled Mean Difference [MD] = -0.10, 95% confidence intervals [CIs]: -0.14 to -0.06). The subgroup analysis revealed a consistent trend at different time points during the follow-up. Significant decrease in the FHP rate were identified at the postoperative 1-2 years (pooled MD = -0.01, 95% CIs: -0.02 to -0.00) rather than at 2-5, 5-7, and 7-10 years. The combined results of clinical scores demonstrated no significant changes in the HHS, NRS, and EQ-5D variables. Additionally, no significant differences in the revision and cup inclination angle were identified during the follow-up period.</p><p><strong>Conclusions: </strong>This study indicated that HXLPE/Vit E liner in total hip arthroplasty may decrease the femoral head penetration, mainly due to the decreased wear in proximal directions. However, no improvement on the clinical functions and complications were identified, and whether HXLPE/Vit E has the potential to prevent implant loosening or revision surgery could not be identified, which requires to be elaborated by high-quality randomized controlled trials.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"72"},"PeriodicalIF":2.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of cervical spine flexion-extension motion on odontoid parameters.","authors":"Longao Huang, Dun Liu, Hongyuan Xu, Junfei Feng, Tao Kang, Shengwang Wei, Hua Jiang","doi":"10.1186/s13018-025-05488-7","DOIUrl":"10.1186/s13018-025-05488-7","url":null,"abstract":"<p><strong>Objective: </strong>To assess the stability of odontoid parameters on flexion-extension motion and to validate the accuracy of the physiological cervical lordosis (CL) predictive formula across different cervical positions.</p><p><strong>Methods: </strong>Standard cervical spine lateral radiographs in neutral, flexion, and extension positions were collected to measure odontoid incidence (OI), odontoid tilt (OT), C2 slope (C2S), CL, T1 slope (T1S), and T1S minus CL (T1S-CL). Friedman's test was used to assess the differences in parameters among the three cervical spine positions. The predictive performance of the formula CL = 0.36× OI - 0.67 × OT - 0.69 × T1S was assessed and validated using the Pearson correlation coefficient (r), coefficient of determination (R²), mean squared error (MSE), and mean absolute error (MAE).</p><p><strong>Results: </strong>No significant differences were found for OI and T1S among the three different cervical spine positions (p = 0.162 and p = 0.186, respectively). There was a strong, significant positive correlation between the predicted value and actual value of physiological CL at three cervical positions (neutral, flexion, and extension). The predictions for the neutral position were the most accurate, with statistical measures of r = 0.85 (p < 0.01), R²=0.82, MAE = 4.28, and MSE = 27.77.</p><p><strong>Conclusion: </strong>OI is a stable and reliable anatomic parameter, not affected by cervical spine flexion-extension motion. OI can serve as a supplementary parameter for evaluating cervical sagittal balance and compensatory ability. The formula CL = 0.36×OI - 0.67×OT - 0.69×T1S provides the best predictions for physiological CL in the neutral position.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"68"},"PeriodicalIF":2.8,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An examination of ankle joint position sense, postural control and associated neuromuscular deficits in patients with plantar fasciitis: a cross-sectional analysis with advanced biomechanical and psychosocial correlates.","authors":"Shaker Hassan S Alshehri, Mastour Saeed Alshahrani, Saeed Y Al Adal, Faisal M Alyazedi, Hani Hassan Alnakhli, Ravi Shankar Reddy","doi":"10.1186/s13018-025-05485-w","DOIUrl":"10.1186/s13018-025-05485-w","url":null,"abstract":"<p><strong>Background: </strong>Ankle joint position sense (AJPS) accuracy and postural control are crucial for maintaining balance and stability, particularly in individuals with plantar fasciitis who may experience proprioceptive and functional impairments. Understanding how psychosocial factors, such as pain catastrophizing, and biomechanical measures, like muscle strength and gait parameters related to proprioception and postural control, can inform more effective treatment approaches. This study aimed to (1) examine the relationship between AJPS accuracy and biomechanical factors-including postural stability, lower limb muscle strength, and gait parameters-in individuals with plantar fasciitis d (2) analyze the impact of psychosocial factors, including pain catastrophizing, physical activity level, and quality of life, on AJPS accuracy and postural control in this population.</p><p><strong>Methods: </strong>A total of 126 participants (63 with plantar fasciitis and 63 controls) were recruited. AJPS was assessed using a digital inclinometer across four movement directions (plantarflexion, dorsiflexion, inversion, eversion). Postural stability metrics (antero-posterior and medio-lateral sway) were measured using computerized posturography, while muscle strength in plantar flexors, dorsiflexors, inverters, and evertors was assessed with a hand-held dynamometer. Gait parameters (step length, cadence, stance time) were captured via 3D motion capture. Pain catastrophizing, physical activity, and quality of life were evaluated using validated questionnaires (PCS, IPAQ, FHSQ).</p><p><strong>Results: </strong>Significant differences were observed in AJPS accuracy between groups, with plantar fasciitis patients showing higher AJPS error in plantarflexion (mean difference = 1.22°, p < 0.001) and dorsiflexion (mean difference = 1.31°, p < 0.001). Pain catastrophizing was a significant predictor of AJPS in plantarflexion (β = -0.05, p = 0.001). Postural stability was negatively correlated with AJPS accuracy, particularly in mediolateral sway (r = -0.32, p = 0.037), while physical activity and quality of life had minimal effects.</p><p><strong>Conclusion: </strong>This study highlights the impact of pain catastrophizing on proprioceptive deficits in plantar fasciitis, emphasizing the importance of addressing psychological as well as biomechanical factors in treatment. Integrating cognitive-behavioral strategies may enhance proprioceptive accuracy and stability outcomes in this population.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"67"},"PeriodicalIF":2.8,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Femoral neck system (FNS) versus 4 cannulated compression screws (CCSs) in the treatment of young patients with Pauwels type III femoral neck fracture: a retrospective comparative study.","authors":"Yang Gao, Tianle Ma, Xiaohu Chang, Peng Jia, Xiaoteng Li, Xin Tang","doi":"10.1186/s13018-025-05461-4","DOIUrl":"10.1186/s13018-025-05461-4","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the clinical effectiveness of the femoral neck system (FNS) compared to four cannulated compression screws (CCSs) for managing Pauwels type III femoral neck fractures in young patients.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on young patients with Pauwels type III femoral neck fractures treated at our hospital from January 2021 to December 2022. Patients were categorized into two groups based on their respective internal fixation methods: the FNS group (32 cases) and the CCSs group (41 cases). Various demographic and clinical variables, including age, gender, fracture side, mechanism of injury, Garden classification, and time interval between injury and surgery, were collected. Comparisons were made between the two groups regarding operative duration, intraoperative blood loss, length of hospital stay, hospitalization expenses, time to fracture healing, and Harris hip score at one year post-surgery. Additionally, postoperative complications such as wound infections, nonunion, femoral neck shortening, avascular necrosis of the femoral head, and hardware failure were analyzed. Follow-up duration ranged from 12 to 24 months for all patients.</p><p><strong>Results: </strong>There were no significant differences between the FNS and CCSs groups in terms of demographic characteristics, fracture characteristics, time to fracture healing, duration of hospital stay, and Harris hip score at one year post-surgery (p > 0.05). However, the CCSs group exhibited significantly shorter operative time, reduced intraoperative blood loss, and lower hospitalization costs compared to the FNS group (p < 0.05). Patients treated with FNS had longer operative durations (82.33 ± 28.85 min vs. 66.58 ± 14.38 min, p = 0.006), higher blood loss (106.67 ± 65.83 mLvs.70.00 ± 27.39 mL, p < 0.001), and increased hospitalization expenses (58,345.98 ± 3706.57 RMB vs. 35,427.63 ± 3019.30 RMB, p < 0.0001). The incidence of postoperative complications was 21.8% in the FNS group and 26.8% in the CCSs group (p > 0.05), with no significant differences observed in the rates of wound infections, femoral neck shortening, femoral head necrosis, nonunion, and hardware failure between the two groups (p > 0.05).</p><p><strong>Conclusion: </strong>In the management of Pauwels type III femoral neck fractures in young patients, FNS demonstrates clinical efficacy comparable to CCSs. However, considering factors such as operative time, intraoperative blood loss, and hospitalization costs, CCSs may be preferred.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"65"},"PeriodicalIF":2.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of stem cells alone and in combination with low-level laser therapy for sciatic nerve repair in rats.","authors":"Mohsen Shalalvand, Hamidreza Mahaseni Aghdam, Ahmad Asghari, Siamak Nehzat, Fatemeh Shahsavari, Rojin Ardalani","doi":"10.1186/s13018-025-05455-2","DOIUrl":"10.1186/s13018-025-05455-2","url":null,"abstract":"<p><p>This study evaluated the efficacy of tubular constructs containing stem cells and Type I collagen, both independently and in conjunction with low-level laser therapy (LLLT), in repairing the sciatic nerve in a rat model. In this animal study, the right sciatic nerve of 30 male Wistar rats, each weighing 250-300 g, was surgically excised to a length of 8 mm. The rats were then randomly allocated to three groups (n = 10 per group). In Group 1, the excised nerve segment was utilized as an autograft and sutured at the defect site. In Group 2, a tubular construct containing stem cells and Type I collagen was used to bridge the proximal and distal ends of the nerve. Group 3 received the same intervention as group 2, supplemented with 5 weeks of LLLT. After 5 and 12 weeks, rats underwent histological, behavioral, and electrophysiological assessments. Data were statistically analyzed using analysis of variance (ANOVA), Bonferroni post-hoc test, and Kruskal-Wallis test. At both 5 and 12 weeks, axonal count and nerve repair scores showed no significant differences among the three groups (P > 0.05). Notably, the Sciatic Functional Index (SFI) was the most favorable (lowest) in the autograft group, whereas the stem cell-only group exhibited the least favorable (highest) SFI at 5 weeks (P < 0.001). Additionally, distal latency was highest in the stem cell group and lowest in the stem cell combined with LLLT group at 5 weeks (P < 0.001). A significant difference was observed between the autograft and stem cell plus LLLT groups (P < 0.05). In conclusion, the application of stem cell-laden tubular constructs in conjunction with LLLT demonstrated efficacy for sciatic nerve repair in rats.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"66"},"PeriodicalIF":2.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superior biomechanical stability of pedicle screws compared to lateral mass screws: recommendations for bicortical positioning and enhancing bone contact in geriatric C1 vertebrae.","authors":"Leon-Gordian Leonhardt, Leonie Rörup, Anna Lena Kammal, Michael Hahn, Marc Dreimann, Benjamin Ondruschka, Felix Nikolai von Brackel, Tim Rolvien, Lennart Viezens, Simon von Kroge","doi":"10.1186/s13018-025-05472-1","DOIUrl":"10.1186/s13018-025-05472-1","url":null,"abstract":"<p><strong>Background: </strong>In atlantoaxial instabilities, posterior C1/C2 fusion using lateral mass screws (LMS) or pedicle screws (PS) in a mono- or bicortical position in the atlas is a typical treatment. The bone microstructure and positioning of the screw trajectories appear to be of significant relevance for stability.</p><p><strong>Purpose: </strong>The aim of this study was a comparative analysis of the mechanical durability of screw fixation concerning microstructural characteristics of the trajectories of LMS and PS in mono- and bicortical position.</p><p><strong>Methods: </strong>Human C1 from geriatric body donors (n = 28; 50% female, age 80.8 ± 13.9 years) were collected and characterized based on their bone microstructure. Additionally, the mechanical stability of LMS and PS fixation in mono- and bicortical positioning was tested by mechanical loading. High-resolution quantitative computed tomography was used to analyze the bone microstructure of cylinders corresponding to the trajectories of PS and LMS in mono- and bicortical locations in each C1. After instrumentation with both screw types and types of fixation, the mechanical stability was tested by increased cyclic loading in cranio-caudal direction.</p><p><strong>Results: </strong>Trajectories of PS presented with more bone volume and a higher contact length to cortical bone. Simultaneously, a higher number of cycles and a higher maximum force was needed to loosen PS compared to LMS, while the loose by torque at the experiment end was still greater in PS. Differences between mono- and bicortical positioning of PS and LMS have only been observed in the initial stiffness of screws. When comparing microstructural and mechanical properties, the cortical contact length and bone volume in screw trajectories were strongest associated with a high loose and cycle count.</p><p><strong>Conclusions: </strong>This study suggests that mono- and bicortical positioning of PS is similarly efficient in creating a stable basis for screw fixation in the atlas. While PS are superior to LMS, the contact with cortical bone is of major relevance for a stable foundation.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"63"},"PeriodicalIF":2.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of osteokines in spinal cord injury: potential biomarkers during rehabilitation.","authors":"Jing Liu, Jingyi Yang, Qi Wu, Zixuan Fang, Tong Wang, Zun Wang, Daoming Xu","doi":"10.1186/s13018-024-05415-2","DOIUrl":"10.1186/s13018-024-05415-2","url":null,"abstract":"<p><p>After spinal cord injury (SCI), mechanical unloading, denervation, as well as negative changes in blood supply, inflammation state, and hormone levels produce significant negative effects on bone density, leading to a high prevalence of osteoporosis after SCI. It has been recently discovered that skeletal bone also has endocrine functions. Osteokines, secreted from bone tissue, could play multiple roles in regulating bone density, muscle mass, glucose metabolism, and functions of the central nervous system-changes in the osteokine levels after SCI have been detected. Therefore, bone density and osteokine levels should be stressed in clinical settings. Clinical treatment measures for bone loss after SCI include exercise training, physical agent therapy, acupuncture, and so on. According to previous studies, these treatments could affect the expression levels of osteokines. In conclusion, bone loss and changes in osteokines after SCI are worthy of great attention during the rehabilitation of SCI. Osteokines could become biomarkers during SCI rehabilitation, reflecting both bone density and systemic functions. This review summarized recent findings regarding bone loss after SCI, changes in osteokines, and the effect of rehabilitation therapies, with a particular emphasis on the local and systemic regulatory roles of osteokines, as well as their potential as biomarkers during SCI rehabilitation.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"64"},"PeriodicalIF":2.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B-doped nano-hydroxyapatite facilitates proliferation and differentiation of osteoblasts.","authors":"Qiao Kang, Wenhao Wang, Shengtao Wu, Ganggang Hu","doi":"10.1186/s13018-024-05414-3","DOIUrl":"10.1186/s13018-024-05414-3","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to explore the mechanism by which Boron-doped nano-hydroxyapatite (B-nHAp) facilitates the proliferation and differentiation of osteoblasts through controlled release of B.</p><p><strong>Methods: </strong>B-nHAp characterization was accomplished by means of X-ray diffraction, scanning electron microscopy, inductively coupled plasma mass spectrometry, and transmission electron microscopy. Human bone marrow mesenchymal stem cells (hBMSCs) were subjected to flow cytometry, alizarin red S staining, and cell counting kit-8 assay for proliferation and differentiation determination. Western blotting for protein expression detection together with real-time quantitative polymerase chain reaction for mRNA expression measurement were carried out on those related to hBMSC proliferation and differentiation. Immunofluorescence staining was conducted to determine the activity of the Wnt/β-catenin signaling pathway.</p><p><strong>Results: </strong>B-nHAp particles had structured configuration and uniform size, and a typical nHAp crystal structure. The B content in B-nHAp was in line with expectation. hBMSCs displayed stemness. B-nHAp significantly facilitated the proliferation of hBMSCs, and significantly more mineralized nodules formed in the B-nHAp group. B-nHAp significantly upregulated the expressions of marker molecules related to hBMSC proliferation and differentiation. B-nHAp boosted the activity of the Wnt/β-catenin signaling pathway.</p><p><strong>Conclusion: </strong>B-nHAp modulates the Wnt/β-catenin signaling pathway to significantly enhance the proliferative and differential abilities of osteoblasts, potentially as an efficient material for bone repair.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"62"},"PeriodicalIF":2.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tetramethylpyrazine promotes osteo-angiogenesis during bone fracture repair.","authors":"Jiangbo Ai, Jingzhou Zheng","doi":"10.1186/s13018-024-05371-x","DOIUrl":"10.1186/s13018-024-05371-x","url":null,"abstract":"<p><strong>Background: </strong>Nonunion following a long bone fracture has gained a lot of attention due to the dreadful impact on the life quality of tremendous patients. Recent data have demonstrated the important involvement of angiogenesis in improving fracture healing. Tetramethylpyrazine (TMP) is an active component of Chinese herbal medicine with various biological activities including pro-angiogenesis property. However, the activity and mechanism of action of TMP in osteo-angiogenesis during bone fracture repair bone fracture healing remain unknown. In this study, TMP was tested for its specific activities in rat aortic endothelial cells (RAECs) and fractured rat model.</p><p><strong>Methods: </strong>The effect of TMP on angiogenesis and migration in RAECs was detected by conducting matrigel tubulogenesis assay and transwell assay. Histopathological changes were observed in the rats from each group using H&E staining. The levels of inflammation and coagulation markers in rats were evaluated by ELISA. The expression of osteogenesis-related genes in rats was assessed by RT-qPCR and western blotting.</p><p><strong>Results: </strong>TMP promoted angiogenesis processes and migratory ability in RAECs. TMP improved histopathological changes in fractured rat model. The concentration of inflammatory markers (IL-2, IL-6, IL-1beta) in the serum of fractured rats were suppressed by TMP treatment. TMP also had the potential to inhibit blood coagulation in rat tibia fracture model. In addition, the expression and protein levels of osteogenesis-related markers (ALP, Runx2, and OPN-1) were elevated by TMP in the tissues from the fractured rats. In mechanism, TMP significantly promoted the activation of VEGF/FLK1 pathway in vitro and in vivo.</p><p><strong>Conclusion: </strong>TMP accelerated the repair of bone fracture by promoting angiogenesis and osteogenesis.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"58"},"PeriodicalIF":2.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of forearm rotation on wrist flexor and extensor muscle activities.","authors":"Kazuhiro Ikeda, Koji Kaneoka, Naoto Matsunaga, Akira Ikumi, Masashi Yamazaki, Yuichi Yoshii","doi":"10.1186/s13018-024-05363-x","DOIUrl":"10.1186/s13018-024-05363-x","url":null,"abstract":"<p><p>The forearm muscles coordinately control wrist motion, and their activity is affected by forearm rotation. Although forearm rotation has been implicated in the development of lateral and medial epicondylitis, its biomechanical background remains unknown. Therefore, the present study investigated the activity of wrist muscles in various forearm positions. Surface electromyography of the extensor carpi radialis brevis, extensor carpi ulnaris, flexor carpi radialis, and flexor carpi ulnaris was performed on 40 healthy upper limbs. We initially measured muscle strength and electromyographic activity (integrated electromyographic value per second) at maximum voluntary output towards wrist extension and flexion in a neutral position. We then assessed electromyographic activity under constant wrist torque (75% of maximum strength in the neutral position) in pronation, the neutral position, and supination. The percentage of maximum electromyographic activity was evaluated for each position. In wrist extension, the extensor carpi radialis brevis was activated during forearm pronation, while extensor carpi ulnaris activity did not change in any forearm position. In wrist flexion, the flexor carpi radialis was activated during forearm supination, while flexor carpi ulnaris activity was significantly lower with forearm pronation than in the neutral position. Since muscle activation increases traction force at the tendon origin, forearm positions that increase muscle activity may be a biomechanical risk factor for the development of tendinopathy. The present results are consistent with epidemiological and pathological findings on lateral and medial epicondylitis. These results provide insights into wrist biomechanics and the pathophysiology of lateral and medial epicondylitis.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"53"},"PeriodicalIF":2.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}