Journal of Orthopaedic Surgery and Research最新文献

{"title":"Efficacy of radiofrequency microdebridement (TOPAZ) in tendinopathy: a systematic review and meta-analysis of randomised clinical trials.","authors":"Cheryl Loh, Stella Polzer, Neal Millar, Dimitris Challoumas","doi":"10.1186/s13018-026-06827-y","DOIUrl":"https://doi.org/10.1186/s13018-026-06827-y","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of our systematic review and meta-analysis was to assess the outcomes associated with the use of radiofrequency microdebridement (RM; TOPAZ) as compared to other interventions in all tendinopathies.</p><p><strong>Methods: </strong>We searched multiple databases for RCTs reporting efficacy outcomes associated with the use of RM in any type of tendinopathy, compared to any other treatment or no treatment. Outcome measures of interest included patient-reported pain visual analogue scale (VAS, primary outcome), patient-reported function and complications (secondary outcomes). Outcomes were pooled separately at short- (up to 12 weeks), mid- (13-52 weeks) and long-term (more than 52 weeks) follow-up. Risk of bias of each study and certainty of evidence of each result were assessed using the Cochrane Collaboration and GRADE tools, respectively.</p><p><strong>Results: </strong>Nine RCTs with a total of 318 patients were included. For the primary outcome, when comparing RM with surgical release, no statistically significant differences were found at any follow-up time point when all tendinopathies were combined [lateral elbow, shoulder, Achilles; short-term mean difference, MD, 0.32, 95% confidence interval (-1.19 to 1.83); mid-term MD 0.09 (-0.22 to 0.40); long-term MD -0.04 (-0.30 to 0.23)] or when lateral elbow tendinopathy, shoulder and Achilles tendinopathies were analysed separately (low certainty evidence). When comparing RM with physiotherapy in Achilles tendinopathy, RM was statistically superior for pain at long-term follow-up [MD -3.50 (-4.90 to -2.10), low certainty, single study]. Finally, when RM was added to surgical release in shoulder and gluteal tendinopathy, there were no significant pain-relieving benefits compared to surgical release alone at short-, mid- or long-term follow-up for shoulder, and long-term follow-up for gluteal. Some functional short- and mid-term benefits were observed with the use of RM in some tendinopathies.</p><p><strong>Conclusion: </strong>Based on the existing evidence, the use of RM is associated with generally equivalent outcomes compared to surgical release for the included tendinopathies. A formal cost analysis may be useful in the future for definitive conclusions, as well as more high-quality RCTs.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supercritical carbon dioxide decellularization of porcine annulus fibrosus for regenerative medicine.","authors":"Lien-Chen Wu, Yueh-Ying Hsieh, Chia-Hsien Chen, Ting-Shuo Hsu, Chang-Jung Chiang","doi":"10.1186/s13018-026-06821-4","DOIUrl":"10.1186/s13018-026-06821-4","url":null,"abstract":"<p><strong>Background: </strong>Scaffold implantation has emerged as a promising therapeutic strategy for the repair of intervertebral disc (IVD) herniation and degeneration. Decellularized scaffolds enhance the biocompatibility and feasibility of xenogeneic transplantation; however, conventional decellularization methods may introduce cytotoxic residues that impair IVD regeneration. In this study, we utilized supercritical CO₂ (scCO₂) to decellularize porcine annulus fibrosus (AF) tissue for potential IVD reconstruction.</p><p><strong>Methods: </strong>By combining freeze-thaw cycles with scCO₂, we optimized the decellularization protocol and evaluated the structural and biochemical characteristics of the resulting scaffolds.</p><p><strong>Results: </strong>Our findings indicate that this method effectively disrupts cellular components while significantly reducing residual nucleic acids and α-Gal xenogeneic antigens, thereby lowering immunogenicity. Importantly, the decellularization process preserved collagen content without causing denaturation or degradation. Although glycosaminoglycan (GAG) content was reduced, the porous structure of the scaffolds remained intact, which is critical for nutrient diffusion and potential cell infiltration following implantation. Furthermore, the decellularized scaffolds were processed under conditions expected to minimize biological contamination, suggesting their potential suitability for subsequent biomedical applications.</p><p><strong>Conclusions: </strong>These results demonstrate that the optimized decellularization method can generate structurally preserved annulus fibrosus scaffolds with reduced immunogenic components, supporting their potential application in spinal tissue engineering.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13151132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical properties of mature porcine anterior cruciate ligaments (ACL) and the impact of cyclic loading.","authors":"Mohamad Agha Mahmoud, Tara Rashid, Michel Paul Johan Teuben, Johannes Greven, Filippo Migliorini, Sven Nebelung, Christian David Weber, Nicola Maffulli, Frank Hildebrand, Hans-Christoph Pape, Miguel Pishnamaz","doi":"10.1186/s13018-025-06143-x","DOIUrl":"https://doi.org/10.1186/s13018-025-06143-x","url":null,"abstract":"<p><strong>Background: </strong>Experimental modelling is required to test novel anterior cruciate ligament (ACL) grafts. Porcine ACLs resemble human ACLs regarding in situ force distribution and anatomic characteristics. However, their essential properties remain unclear. This study describes essential baseline porcine ACL properties and determines the impact of standardised cyclic loading.</p><p><strong>Methods: </strong>Twenty mature porcine cadaver knee joints were used for standardised biomechanical testing. Axial tensile loading was performed, and force to failure (F_max), elongation, stiffness, yield point, and absorbed energy by ACL ligament were determined. Baseline values were compared with samples exposed to cyclic loading (10.000 runs).</p><p><strong>Results: </strong>Dimensions were determined by computed tomography (CT) scanning. ACLs showed a mean F_max of 720.5 N ± 108.6 N, whereas a mean F_max of 614.9 N ± 98.1 N was found upon cyclic loading, p = 0.07. Stiffness did not differ between groups (baseline: 76.9 N/mm ± 8.9 N/mm vs. after cyclical loading: 76.1 N/mm ± 9.5 N/mm, p = 0.8). Furthermore, sample elongation during cyclic loading was unaltered. A biphasic pattern of ACL rupturing, reflecting two separate porcine bundles, was identified.</p><p><strong>Conclusion: </strong>Two separate porcine bundles have been identified as being in line with humans. The robust results of this study underline the applicability of this model to the human condition. Moreover, specific features of porcine ACL may form a template for developing synthetic ligaments and tailored treatment protocols.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147530168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond local injury: pathogenic roles of metabolic, endocrine, and aging-associated systemic factors in tendinopathy and novel therapeutic strategies.","authors":"Yuqi Lin, Zhichao Liu, Lianjie Peng, Shihan Wang, Kun Li, Xingyu Lv, Jianxiang He","doi":"10.1186/s13018-026-06820-5","DOIUrl":"10.1186/s13018-026-06820-5","url":null,"abstract":"<p><p>Tendinopathy, characterized by persistent pain and impaired function, is a globally prevalent condition imposing heavy socioeconomic burdens. Long regarded as an isolated local lesion, it is increasingly recognized as a regional manifestation of systemic dysregulation driven by the metabolic-endocrine-aging axis-not merely a peripheral \"background factor.\" This review systematically analyzes four key pathogenic pathways: hyperglycemia-induced advanced glycation end-product (AGE) deposition, dyslipidemia-driven metabolic inflammation, sex hormone fluctuation-mediated collagen homeostasis disruption, and the cellular senescence-senescence-associated secretory phenotype (SASP) cascade. Together, these systemic factors remodel the tendon cell microenvironment, alter extracellular matrix biomechanics, and reduce the tissue's mechanical load tolerance. Traditional local-focused treatments have demonstrated limited efficacy, requiring a shift to a \"systemic-local synergistic regulation\" paradigm. Critically, a new clinical staging system integrating systemic risk factors is urgently needed. By establishing a \"systemic-local\" crosstalk model and highlighting the urgent need for a novel clinical staging system integrating systemic risk factors-our primary novel contribution-this review provides key insights for researchers and clinicians, supporting the optimization of personalized therapeutic strategies and improved clinical outcomes for tendinopathy.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147530203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: METTL3 accelerates staphylococcal protein A (SpA)-induced osteomyelitis progression by regulating m6A methylation-modified miR-320a.","authors":"Ding Gao, Jian Shi, Siyu Lu, Junyi Li, Kehan Lv, Yongqing Xu, Muguo Song","doi":"10.1186/s13018-026-06782-8","DOIUrl":"10.1186/s13018-026-06782-8","url":null,"abstract":"","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13023119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147530189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excessive external rotation of the ipsilateral iliac wing following Pemberton acetabuloplasty: a three-dimensional computed tomography study.","authors":"Yu-Han Chen, Kuan-Wen Wu, Chih-Kai Hong, Chia-Che Lee, Yu-Hung Chen, Ken N Kuo, Ting-Ming Wang","doi":"10.1186/s13018-026-06790-8","DOIUrl":"10.1186/s13018-026-06790-8","url":null,"abstract":"<p><strong>Background: </strong>Emerging evidence suggests that developmental dysplasia of the hip involves not only localized acetabular dysplasia but also internal rotation of the entire innominate bone. Pemberton acetabuloplasty is widely used to improve acetabular coverage in walking-age children and generally yields favorable radiographic and clinical outcomes. However, the effect of this procedure on the global rotational alignment of the innominate bone has not been systematically investigated.</p><p><strong>Methods: </strong>This retrospective comparative study included patients with a primary diagnosis of developmental dysplasia of the hip who underwent Pemberton acetabuloplasty at a tertiary care center between January 2011 and October 2021. Postoperative pelvic computed tomography scans were available for 20 unilateral and 12 bilateral cases, all of which were included in the analysis. In unilateral cases, the operated hemipelvis was compared with the contralateral side using paired t-tests to minimize inter-individual variability. Pelvic rotational parameters were further compared between unilateral and bilateral groups. Finally, data from all operated hips were pooled to evaluate the association between postoperative innominate rotational alignment and acetabular anteversion using Pearson's correlation coefficient.</p><p><strong>Results: </strong>In unilateral cases, the operated side demonstrated significantly greater external rotation of the upper pelvis compared with the contralateral side (mean difference, 3.3°; 95% confidence interval [CI], 0.7°-5.9°; p = 0.002), whereas acetabular anteversion and lower pelvic rotation did not differ significantly. No significant differences in pelvic rotational parameters or acetabular anteversion were observed between unilateral and bilateral procedures. When all operated hips were pooled for analysis, lower pelvic rotation demonstrated a moderate positive correlation with acetabular anteversion (r = 0.614, p < 0.001), while upper pelvic rotation showed a weak but statistically significant correlation (r = 0.308, p = 0.042).</p><p><strong>Conclusions: </strong>Postoperative excessive external rotation of the upper hemipelvis was observed following Pemberton acetabuloplasty, suggesting that structural alterations may extend beyond localized acetabular reshaping. These findings offer additional insight into the broader morphological changes associated with the procedure. Further prospective studies incorporating longitudinal imaging and objective functional assessment are warranted to better define the clinical significance of these structural alterations.</p><p><strong>Level of evidence: </strong>Level III, Retrospective comparative study.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147521129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Freezing nitrogen ethanol composite in treating giant cell tumor of bone: a clinical series of 32 patients.","authors":"Kuan-Lin Chen, Chao-Ming Chen, Abigail R Tud, Po-Kuei Wu, Wei-Ming Chen","doi":"10.1186/s13018-026-06771-x","DOIUrl":"10.1186/s13018-026-06771-x","url":null,"abstract":"<p><strong>Background: </strong>Giant cell tumor of bone (GCTB) is a benign yet locally aggressive tumor that often affects young adults around the knee. Intralesional curettage with adjuvants reduces recurrence but complications remain. Freezing nitrogen ethanol composite (FNEC), a semi-solid cryogen, has emerged as a novel adjunct with promising early results. This study evaluated the mid- to long-term outcomes of FNEC following curettage for GCTB.</p><p><strong>Methods: </strong>A retrospective review of consecutive GCTB patients underwent intralesional curettage and FNEC cryotherapy between 2017 and 2022. A standardized three-phase protocol (pre-cooling, freezing, thawing) was applied after intralesional curettage and before bone grafting or substitute filling, with fixation as required. Demographics, tumor characteristics, and disease status at presentation (primary vs. recurrent), oncological outcome, complications, and functional outcome were recorded.</p><p><strong>Results: </strong>The cohort included 17 men and 15 women, mean age 34.8 years. Eighteen lesions (56.3%) were around the knee, the rest in the distal radius, proximal humerus, proximal femur, talus, and metatarsus. Four recurrences (12.5%) occurred, yielding 2- and 5-year recurrence-free-survival of 93.8% and 90.6%. Patients with primary lesion had superior recurrence-free survival compared with recurrent lesion (95.0% and 95.0% vs. 91.7% and 83.3% at 2 and 5 years). No recurrence was observed in primary knee lesions. Complications included one wound dehiscence and one case of subcutaneous irritation. No fractures or structural collapse was noted. The mean MSTS score was 93.2%.</p><p><strong>Conclusion: </strong>FNEC is a safe and effective adjuvant for curettage in GCTB, achieving excellent local control and functional outcomes with minimal complications.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147530263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of distant metastasis among Chinese osteosarcoma patients: a systematic review and meta-analysis.","authors":"Xinyu Huang, Sanmao Liu, Jiaxing Zeng, Shunyu Lu","doi":"10.1186/s13018-026-06804-5","DOIUrl":"10.1186/s13018-026-06804-5","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to conduct a meta-analysis integrating multiple literature sources to explore the risk factors for distant metastasis (DM) in osteosarcoma (OS).</p><p><strong>Methods: </strong>We searched PubMed, Cochrane Library, Embase, and Web of Science (up to August 16, 2025) for observational studies on risk factors for DM in OS. A meta-analysis was conducted according to the PRISMA guidelines. After data extraction, STATA 15.0 was used to calculate the pooled odds ratio (OR) values and 95% confidence interval (CI).</p><p><strong>Results: </strong>This meta-analysis included 12 studies involving 16,656 patients, of which 2,540 cases had DM, with a prevalence of 15.24%. The meta-analysis results showed that the risk factors for DM in OS were associated with male gender [OR = 0.71, 95%CI (0.59, 0.84), P < 0.001], T2 [OR = 2.26, 95%CI (1.85, 2.75), P < 0.001], T3 [OR = 4.37, 95%CI (2.84, 6.73), P < 0.001], TX [OR = 2.72, 95%CI (1.31, 5.63), P = 0.007], N1 [OR = 4.05, 95%CI (2.29, 7.19), P < 0.001], NX [OR = 2.70, 95%CI (1.40, 5.19), P = 0.003], tumor size (> 10 cm) [OR = 3.37, 95%CI (2.17, 5.22), P < 0.001], tumor size (unknown) [OR = 3.81, 95%CI (2.60, 5.58), P < 0.001], primary site surgery [OR = 0.32, 95%CI (0.17, 0.60), P < 0.001], and bone metastases [OR = 5.81, 95%CI (4.09, 8.24), P < 0.001], but not with tumor grade (low, unknown), tumor size (5-10 cm), axial bone, or radiotherapy.</p><p><strong>Conclusion: </strong>This and previous studies demonstrate that DM in OS is influenced by multiple known risk factors, most of which can be identified during preoperative assessment. The crucial step lies in translating these preoperative insights into concrete postoperative preventive actions. This approach holds significant value for improving clinical management quality and formulating individualized postoperative follow-up and intervention plans. These findings, derived from clinical data within a Chinese population, are particularly applicable to the management of OS patients in China, offering tailored guidance for this demographic.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13141334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147521143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"piR-27222 alleviates dexamethasone-induced osteoporosis by inhibiting ferroptosis through modulating WWP1.","authors":"Yusen Dai, Xile Wen, Daoyou Li, Minghang Chen","doi":"10.1186/s13018-026-06793-5","DOIUrl":"10.1186/s13018-026-06793-5","url":null,"abstract":"","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147521158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The expression characteristics of miR-206-3p in musculoskeletal tissue and its clinical significance.","authors":"Khan Akhtar Ali, Xuefeng Yuan, Tianxiang Cui, Qianqian Yu, Zhiqian Yi, Hui Huang","doi":"10.1186/s13018-026-06785-5","DOIUrl":"10.1186/s13018-026-06785-5","url":null,"abstract":"<p><strong>Background and objective: </strong>Osteosarcopenia, a comorbidity of osteoporosis and sarcopenia in the elderly, involves bone-muscle crosstalk, but its core molecular mechanism remains unclear. miR-206 is traditionally considered muscle-specific; this study explores miR-206-3p's expression in musculoskeletal tissue and correlation with clinical parameters.</p><p><strong>Methods: </strong>A prospective cohort of 158 elderly hip fracture patients (79 osteosarcopenia, 79 controls) was enrolled. qRT-PCR, in situ hybridization, and scRNA-seq were used to analyze miR-206-3p's expression, distribution, and cell specificity. Correlations with grip strength, gait speed, and BMD were assessed.</p><p><strong>Results: </strong>miR-206-3p was significantly downregulated in both tissues of the osteosarcopenia group (P < 0.001), highly expressed in Myod1⁺ muscle satellite cells and Runx2⁺ osteoprogenitor cells (> 82%), and weakly in mature cells (< 12%). It positively correlated with grip strength, gait speed, and BMD (r = 0.562-0.682, P < 0.001).</p><p><strong>Conclusion: </strong>miR-206-3p is co-expressed in bone-muscle progenitor cells, with synchronous downregulation linked to functional decline, challenging its \"muscle-specific\" notion and serving as a key molecular hub for bone-muscle crosstalk.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13141340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}