Journal of Orthopaedic Surgery and Research最新文献

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Safety and efficacy of percutaneous toe flexor tenotomies under local anesthesia in an outpatient setting. 局部麻醉下经皮屈趾肌腱切断术在门诊的安全性和有效性。
IF 2.8 3区 医学
Journal of Orthopaedic Surgery and Research Pub Date : 2026-04-03 DOI: 10.1186/s13018-026-06823-2
Giovanni Manzi, Alexis Nogier, Antonio Izzo, Alessio Bernasconi, Philippe Beaudet
{"title":"Safety and efficacy of percutaneous toe flexor tenotomies under local anesthesia in an outpatient setting.","authors":"Giovanni Manzi, Alexis Nogier, Antonio Izzo, Alessio Bernasconi, Philippe Beaudet","doi":"10.1186/s13018-026-06823-2","DOIUrl":"https://doi.org/10.1186/s13018-026-06823-2","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to assess of the safety and effectiveness of percutaneous toe flexor tenotomies under local anaesthesia in an outpatient setting, in terms of complications, functional outcomes, pain on VAS, and patient satisfaction.</p><p><strong>Methods: </strong>The authors conducted a retrospective observational study of 22 patients with painful lesser toe deformities who underwent flexor tendon tenotomies between 2018 and 2021. Inclusion criteria were (i) flexible or mild rigid deformities with plantar flexion of the distal and/or proximal interphalangeal joints, (ii) pain, footwear discomfort, or cutaneous lesions, (iii) failed conservative treatment consisting of shoe modifications, silicone orthoses, podiatric treatment, and (iv) no contraindications to local anaesthesia. Before the surgery, the authors collected patient characteristics, pain on visual analogue scale (VAS), and the American Orthopaedic Foot and Ankle Society (AOFAS) score. Intraoperatively, total operating room time, and surgical time was recorded. Postoperatively, pain on VAS, AOFAS score, patient satisfaction, duration of analgesic use, and time to return to driving were collected.</p><p><strong>Results: </strong>The cohort of 22 patients, aged 75.9 ± 8.1, comprised 13 men and 9 women, and included 27 feet. Following the surgery, all patients were able to walk unaided and were discharged the same day. There were several complications, including same-day dressing changes due to bleeding (n = 3), persistent MTP hyperextension (n = 1), and reoperation for recurrent deformity which required proximo interphalangeal (PIP) arthrodesis (n = 1). The patients used analgesics for 1.3 ± 1.3 days, and were able to return to driving in 6.3 ± 9.1 days. At follow-up of 19 ± 9.9 months, 21 patients were satisfied and would undergo the procedure again (95%), and only 3 had postoperative ulcers (11%). Pain on VAS decreased from 5.0 ± 2.0 (range, 1-8) to 0.7 ± 1.5 (range, 0-6), while AOFAS improved from 43.4 ± 16.8 (range, 15-75) to 83.5 ± 19.3 (range, 15-100).</p><p><strong>Conclusion: </strong>Percutaneous toe flexor tenotomies under local anaesthesia in an outpatient setting can be performed safely without the need for a full operating theatre, and leads to minimal complications. Furthermore, there was a significant reduction in pain on VAS, and increase in AOFAS score, and almost all patients were satisfied and would undergo the surgery again.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reconstruction of the medial patellofemoral ligament using a double-bundle semitendinosus tendon graft and a single suture anchor. 双束半腱肌腱移植及单缝线锚钉重建髌股内侧韧带。
IF 2.8 3区 医学
Journal of Orthopaedic Surgery and Research Pub Date : 2026-04-03 DOI: 10.1186/s13018-026-06840-1
Weizong Sun, Junchao Zhao, Binyang Meng, Zi Zhang, Liang Zhang, Jiangang Cao
{"title":"Reconstruction of the medial patellofemoral ligament using a double-bundle semitendinosus tendon graft and a single suture anchor.","authors":"Weizong Sun, Junchao Zhao, Binyang Meng, Zi Zhang, Liang Zhang, Jiangang Cao","doi":"10.1186/s13018-026-06840-1","DOIUrl":"https://doi.org/10.1186/s13018-026-06840-1","url":null,"abstract":"<p><strong>Background: </strong>The double bundle medial patellofemoral ligament reconstruction (MPFL-R) is a well-established surgical technique for the management of patellar instability. While double anchor screw fixation on the patellar side is currently favored by many surgeons, this article presents a modified surgical approach involving minor technical modifications that may decrease dependence on internal implants.</p><p><strong>Methods: </strong>From July 2016 to August 2023, the same surgeon performed two distinct MPFL-R procedures on patients with recurrent patellar dislocation. The novel single-anchor MPFL-R technique involves fixing the inferior graft bundle into a surgically created medial bony groove of the patella using a single suture anchor, while the superior bundle is passed through the junction of the vastus medialis obliquus (VMO) tendon and the patella. The double-anchor MPFL-R technique utilizes two suture anchors placed on the patella to separately secure the inferior and superior graft bundles, following the established surgical approach. Functional outcomes were assessed preoperatively and at follow-up using the Kujala, Lysholm, and Tegner scores. Radiological outcomes, including the Insall-Salvati index, tibial tubercle-trochlear groove (TT-TG) distance, and patellar tilt angle (PTA), were also evaluated preoperatively and during follow-up.</p><p><strong>Results: </strong>A total of 40 patients (42 knees) in the single-anchor (SA) group and 72 patients (76 knees) in the double-anchor (DA) group were included. Patient characteristics were comparable between the two groups. Preoperative clinical scores were as follows: Kujala (SA: 59.0 ± 9.2, DA: 60.1 ± 8.1), Lysholm (SA: 62.7 ± 9.1, DA: 61.6 ± 8.3), and Tegner (SA: 2.8 ± 1.0, DA: 3.1 ± 1.3). Postoperative scores improved to Kujala (SA: 88.3 ± 4.7, DA: 90.6 ± 4.8), Lysholm (SA: 90.8 ± 4.2, DA: 91.0 ± 4.9), and Tegner (SA: 4.6 ± 1.2, DA: 4.8 ± 1.5). Radiologically, preoperative patella trochlear angle (PTA) values were SA: 31.8 ± 9.0 and DA: 29.3 ± 10.2, which improved postoperatively to SA: 14.7 ± 8.6 and DA: 12.6 ± 6.3. All postoperative outcomes demonstrated significant improvement compared to preoperative values (P < 0.001). However, no significant differences were observed between the SA and DA groups in any outcome measure (P > 0.05).</p><p><strong>Conclusion: </strong>Single-anchor MPFL-R is a reliable technique for managing recurrent patellar dislocation, demonstrating comparable clinical and radiographic outcomes to the double-anchor approach. This method provides a feasible surgical alternative for surgeons already proficient in the double-anchor technique.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147615829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long non-coding RNA LINC-PINT: emerging clinical significance and molecular mechanisms in knee osteoarthritis. 长链非编码RNA LINC-PINT:膝关节骨关节炎的新临床意义和分子机制。
IF 2.8 3区 医学
Journal of Orthopaedic Surgery and Research Pub Date : 2026-04-02 DOI: 10.1186/s13018-026-06822-3
Shen Zhou, Yushuai Zhang, Shouhai Jiang, Chuankai Zhang
{"title":"Long non-coding RNA LINC-PINT: emerging clinical significance and molecular mechanisms in knee osteoarthritis.","authors":"Shen Zhou, Yushuai Zhang, Shouhai Jiang, Chuankai Zhang","doi":"10.1186/s13018-026-06822-3","DOIUrl":"https://doi.org/10.1186/s13018-026-06822-3","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The underlying pathophysiological mechanisms of knee osteoarthritis (KOA) remain incompletely understood. This study aimed to investigate the clinical significance of long non-coding RNA LINC-PINT in KOA and elucidate its molecular mechanism in regulating chondrocyte function via the miR-324-3p/GPX4 axis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;100 KOA patient samples and 40 normal knee cartilage tissue samples were collected, and the relevant gene expression was quantified using RT-qPCR. C28/I2 was cultured in vitro to establish an IL-1β-induced KOA cellular model. Dual-luciferase reporter and RNA immunoprecipitation (RIP) assays were performed to validate the targeted molecular regulatory interactions. Cell proliferation and apoptosis, as well as inflammatory factors levels, were assessed using cell counting kit-8 (CCK-8), flow cytometry, and enzyme-linked immunosorbent assay (ELISA), respectively. Oxidative stress-related indicators and Fe&lt;sup&gt;2+&lt;/sup&gt; concentration were evaluated using commercial assay kits. Western blotting was performed to detect protein expression.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In KOA tissues, LINC-PINT and glutathione peroxidase 4 (GPX4) were significantly downregulated, whereas miR-324-3p was markedly upregulated. LINC-PINT demonstrated the potential diagnostic discrimination ability and was identified as an independent protective factor in KOA. Overexpression of LINC-PINT effectively counteracted interleukin-1 beta (IL-1β)-induced suppression of chondrocyte proliferation, reduced apoptosis, and attenuated the secretion of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), while significantly alleviating cartilage matrix degradation, as indicated by increased expression of collagen II and aggrecan and decreased matrix metallopeptidase 13 (MMP13) levels. Moreover, LINC-PINT directly bound to miR-324-3p, which in turn directly targeted GPX4. Functional rescue assays further confirmed that transfection with a miR-324-3p mimic reversed the protective effects of LINC-PINT overexpression on chondrocytes, whereas GPX4 overexpression mitigated the detrimental effects induced by the miR-324-3p mimic. IL-1β disrupted the cellular redox balance by increasing the levels of Fe&lt;sup&gt;2+&lt;/sup&gt;, reactive oxygen species (ROS), and (malondialdehyde) MDA and by inhibiting superoxide dismutase (SOD) activity and the GSH/GSSG ratio. Overexpression of LINC-PINT can counteract these effects, and the protective effect was enhanced when combined with Per-1. Transfection with miR-mimic reversed the protective effect of LINC-PINT, suggesting that LINC-PINT may act as a competitive endogenous RNA (ceRNA) to capture this pro-oxidative miR-324-3p. Finally, overexpression of GPX4 could protect cells from miRNA-induced damage, highlighting its crucial role in alleviating iron-dependent oxidative stress and iron-overloaded apoptosis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;LINC-PINT demonstrated the potential diagnostic dis","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and radiologic outcomes of expandable versus static cages in biportal endoscopic TLIF: focus on endplate injury and subsidence. 双门静脉内窥镜TLIF中可伸缩与静态固定架的临床和放射学结果:关注终板损伤和下沉。
IF 2.8 3区 医学
Journal of Orthopaedic Surgery and Research Pub Date : 2026-04-02 DOI: 10.1186/s13018-026-06756-w
Tae Hoon Kang, Geumho Lee, Byungjun Kang, Jeongwoon Han, Hyun-Jin Park, Minjoon Cho, Jae Hyup Lee
{"title":"Clinical and radiologic outcomes of expandable versus static cages in biportal endoscopic TLIF: focus on endplate injury and subsidence.","authors":"Tae Hoon Kang, Geumho Lee, Byungjun Kang, Jeongwoon Han, Hyun-Jin Park, Minjoon Cho, Jae Hyup Lee","doi":"10.1186/s13018-026-06756-w","DOIUrl":"https://doi.org/10.1186/s13018-026-06756-w","url":null,"abstract":"<p><strong>Background: </strong>Expandable cages (ECs) theoretically enhance disc height restoration in biportal endoscopic transforaminal lumbar interbody fusion (BE-TLIF), but concerns persist regarding endplate injury and early subsidence. This study compared the safety and efficacy of ECs versus static cages (SCs) in BE-TLIF.</p><p><strong>Methods: </strong>We retrospectively analyzed 73 BE-TLIF levels (37 ECs, 36 SCs) performed by a single surgeon between May 2023 and May 2025. BE-TLIF allowed direct endplate visualization and routine bilateral facet release. SCs were banana-shaped PEEK or 3D porous titanium cages inserted in the largest feasible size and rotated into position, whereas ECs were bullet-shaped titanium cages expanding only in height. Radiographic outcomes included endplate injury on postoperative CT, subsidence at 6 weeks and 3 months, disc height change, and segmental lordosis/PI-LL. Clinical outcomes were VAS (back/leg), ODI, and FRI.</p><p><strong>Results: </strong>Despite lower BMI and higher BMD in the EC group, subsidence was significantly more frequent with ECs. ECs showed higher endplate injury (18.9% vs. 2.8%, p = 0.030) and greater disc height loss at 6 weeks (- 0.96 ± 1.89 vs. - 0.18 ± 1.37 mm, p = 0.047). Clinically significant (> 2 mm) and severe (> 25% height) subsidence occurred more often with ECs (35.1% vs. 11.1%, p = 0.032; 18.9% vs. 2.8%, p = 0.030). All patients with endplate injury developed subsidence. No new subsidence appeared after 6 weeks. Although ECs achieved greater immediate disc height restoration (4.07 ± 2.28 vs. 2.65 ± 2.13 mm, p = 0.009), they yielded less pain improvement (VAS back: p = 0.004 at 6 weeks, p = 0.029 at 3 months; VAS leg: p = 0.001 at 6 weeks, p = 0.002 at 3 months), while ODI and FRI were comparable. Segmental lordosis and PI-LL correction did not differ.</p><p><strong>Conclusions: </strong>In this short-term analysis of BE-TLIF, ECs are associated with higher risks of endplate injury and early subsidence, leading to inferior early pain outcomes despite superior initial disc height restoration. These drawbacks likely stem from titanium composition, small footprint, and concentrated expansion forces on the central endplate. These findings suggest that, despite the technical advantages of BE-TLIF regarding endplate preparation and bilateral facet release, current EC designs may possess inherent limitations, underscoring the need for cautious use in osteoporotic patients and further investigation into long-term clinical durability.</p><p><strong>Trial registration: </strong>Retrospectively registered.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction Note: A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarthritis (KOA). 摘要:一项荟萃分析和系统评价了富血小板血浆联合透明质酸(PRP + HA)与PRP单药治疗膝关节骨关节炎(KOA)的临床疗效和安全性。
IF 2.8 3区 医学
Journal of Orthopaedic Surgery and Research Pub Date : 2026-04-01 DOI: 10.1186/s13018-026-06838-9
Dan Du, Yuan Liang
{"title":"Retraction Note: A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarthritis (KOA).","authors":"Dan Du, Yuan Liang","doi":"10.1186/s13018-026-06838-9","DOIUrl":"10.1186/s13018-026-06838-9","url":null,"abstract":"","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"21 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13041170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging pathogenetic mechanisms in adolescent idiopathic scoliosis: the role of inflammation and gut microbiota. 青少年特发性脊柱侧凸的新发病机制:炎症和肠道微生物群的作用。
IF 2.8 3区 医学
Journal of Orthopaedic Surgery and Research Pub Date : 2026-04-01 DOI: 10.1186/s13018-026-06837-w
Bartosz Kruk, Karolina Skonieczna-Żydecka, Wiktoria Czarnecka, Natalia Tuczyńska, Albert Podkówka, Piotr Szredzki, Grzegorz Pasternak, Karolina Kokot, Jowita Biernawska, Sławomir Zacha
{"title":"Emerging pathogenetic mechanisms in adolescent idiopathic scoliosis: the role of inflammation and gut microbiota.","authors":"Bartosz Kruk, Karolina Skonieczna-Żydecka, Wiktoria Czarnecka, Natalia Tuczyńska, Albert Podkówka, Piotr Szredzki, Grzegorz Pasternak, Karolina Kokot, Jowita Biernawska, Sławomir Zacha","doi":"10.1186/s13018-026-06837-w","DOIUrl":"https://doi.org/10.1186/s13018-026-06837-w","url":null,"abstract":"<p><strong>Purpose: </strong>This narrative review was conducted to analyse current evidence on inflammation-related mechanisms contributing to the pathogenesis and progression of adolescent idiopathic scoliosis (AIS).</p><p><strong>Methods: </strong>A comprehensive narrative synthesis of studies investigating inflammatory biomarkers, immune cell phenotypes, cytokine pathways, paraspinal muscle immunobiology, gut microbiota composition, and their mechanistic links to bone and muscle remodeling in AIS was performed. Evidence was integrated from clinical, genetic, histological, microbiological, and experimental models.</p><p><strong>Results: </strong>Evidence indicates that AIS is associated with chronic low-grade inflammation affecting systemic immunity, bone metabolism, and paraspinal muscle structure. Altered cytokine activity (IL-6, IL-1β, TNF-α, IL-17) promotes osteoclastogenesis, extracellular matrix degradation, and reduced bone mineral density. Paraspinal muscles on the concave side exhibit fibrosis, macrophage imbalance, and impaired regeneration, consistent with persistent inflammatory signalling. Additionally, gut microbiota dysbiosis-characterized by reduced bacteria producing short chain fatty acids (SCFA) and increased pro-inflammatory taxa-may contribute to endotoxemia, immune activation, and disruption of the gut-bone-muscle axis. Inflammatory markers such as the neutrophil-to-lymphocyte ratio correlate with curve severity, and genetic and Mendelian randomization analyses suggest that specific microbial taxa may modulate AIS risk.</p><p><strong>Conclusions: </strong>Current evidence supports a multifactorial biological model of AIS in which chronic low-grade inflammation acts as a central integrator of systemic and local pathogenic processes. Altered cytokine signaling and immune cell imbalance promote dysregulated bone remodeling via the RANKL/RANK pathway, while persistent inflammatory activation within paraspinal muscles contributes to fibrosis, impaired regeneration, and biomechanical asymmetry. In parallel, gut microbiota dysbiosis may further amplify inflammatory signalling through intestinal barrier dysfunction, reduced production of anti-inflammatory microbial metabolites, and activation of the gut-bone-muscle axis. Although causal relationships remain to be fully established, these interconnected mechanisms provide a coherent framework linking immune dysregulation, musculoskeletal remodeling, and curve progression in AIS, highlighting opportunities for biomarker discovery and the development of targeted preventive and adjunctive therapeutic strategies.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accuracy and heterogeneity of histological analysis for detecting periprosthetic joint infections. 检测假体周围关节感染的组织学分析的准确性和异质性。
IF 2.8 3区 医学
Journal of Orthopaedic Surgery and Research Pub Date : 2026-04-01 DOI: 10.1186/s13018-026-06817-0
Jiazheng Xu, Lihua Zhang, Yunhao Tang, Zhigang Song, Wei Chai, Rui Li
{"title":"Accuracy and heterogeneity of histological analysis for detecting periprosthetic joint infections.","authors":"Jiazheng Xu, Lihua Zhang, Yunhao Tang, Zhigang Song, Wei Chai, Rui Li","doi":"10.1186/s13018-026-06817-0","DOIUrl":"https://doi.org/10.1186/s13018-026-06817-0","url":null,"abstract":"<p><strong>Background: </strong>Intraoperative frozen section histology is a cornerstone for diagnosing periprosthetic joint infection (PJI), yet its reported accuracy varies significantly. Previous studies have primarily focused on the accuracy of histopathological diagnosis for PJI, with analysis of heterogeneous sources remaining insufficient. This study aimed to systematically evaluate the diagnostic accuracy of frozen sections for PJI and, specifically, to analyze where the discrepancies may exist.</p><p><strong>Methods: </strong>We retrospectively reviewed 171 patients (89 PJI, 82 Aseptic) undergoing revision hip or knee arthroplasty (2015-2023). PJI was defined strictly by International Consensus Meeting (ICM) major criteria to avoid incorporation bias. Aseptic failures were confirmed by a lack of infection signs and > 2 years of survival without antibiotic usage. Diagnostic performance of frozen section in the diagnosis of PJI was evaluated. Histological heterogeneity was quantified by analyzing the concordance rate across three distinct tissue specimens per case. We further compared diagnostic accuracy using different interpretation strategies: requiring either one, two, or three positive samples to confirm the diagnosis. Additionally, inter-observer agreement was assessed by two independent pathologists re-evaluating 81 sections.</p><p><strong>Results: </strong>The overall sensitivity was 71.9% (95% CI 61.4-80.9%) and specificity was 75.6% (95% CI 64.9-84.4%), with an area under the curve (AUC) of 0.738 (95% CI 0.672-0.803). Diagnostic performance was consistent between hip and knee revisions (p = 0.829). Notably, histological heterogeneity was prevalent: among confirmed PJI cases, only 44.0% (37/84) exhibited consistent positive results across all three specimens, whereas 73.7% of aseptic cases were consistently negative. Among the three specimens, if consider at least one specimen had >5 neutrophils per high power field in 5 high power fields (×400) as histology positive, the sensitivity and specificity was 70.2% (59.3-79.7%) and 73.7% (62.3-83.1%), respectively. Furthermore, inter-observer agreement was moderate (Kappa = 0.581), suggesting that diagnostic interpretation varies between pathologists.</p><p><strong>Conclusion: </strong>Intraoperative frozen section analysis provides reliable diagnostic accuracy for patients meeting ICM Major Criteria, with consistent performance across hip and knee revisions. However, the significant heterogeneity existed in both surgical sampling and pathological interpretation. Standardization from the surgeon's intraoperative sampling to the pathologist's result interpretation stage may offer a potential solution to this problem.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of foot and ankle training combined with traditional Chinese medicine massage and self-myofascial release are effective in postoperative rehabilitation of calcaneal fractures. 足踝关节训练结合中医推拿和自我肌筋膜松解对跟骨骨折术后康复效果显著。
IF 2.8 3区 医学
Journal of Orthopaedic Surgery and Research Pub Date : 2026-04-01 DOI: 10.1186/s13018-026-06824-1
Tao Su, Zeyang Li
{"title":"Effect of foot and ankle training combined with traditional Chinese medicine massage and self-myofascial release are effective in postoperative rehabilitation of calcaneal fractures.","authors":"Tao Su, Zeyang Li","doi":"10.1186/s13018-026-06824-1","DOIUrl":"https://doi.org/10.1186/s13018-026-06824-1","url":null,"abstract":"<p><strong>Objective: </strong>To explore the intervention effect of foot and ankle training combined with plantar fascia stress training on postoperative heel fracture patients.</p><p><strong>Methods: </strong>Seventy-eight patients with heel fracture who underwent surgical treatment in the orthopedic inpatient department of a hospital from February 2020 to October 2020 were selected as the study subjects, and a randomized controlled trial was conducted with postoperative follow-up. These patients were randomly grouped to obtain the control group (Group D) and the intervention group (Group G), which had the same number of cases, 39 cases. Group D only underwent routine ankle training, including dorsiflexion, plantarflexion, and internal and external rotation exercises of the ankle joint. On the basis of group D, group G added plantar fascia stress training, and used foam rollers and solid rubber balls as auxiliary tools for plantar rolling exercises, 3 groups a day, 50 times in each group. And during the intervals of rolling exercises, combine traditional Chinese medicine massage and acupoint pressing, maintain for about 30 s each time, and repeat 2-3 times.</p><p><strong>Results: </strong>At the end of the experiment, unlike patients in group D, patients in group G had higher Maryland foot scores, lower swelling values, lower visual analog pain scores, lower probability of complications (P < 0.05), higher vitality scores, shorter time to incision healing, shorter time to fracture healing, higher percentage of the healthy support phase to the total cycle of the healthy gait, higher treatment compliance scores, and higher overall effective rate was higher (P < 0.001). The total effective rate in group G was 97.44%.</p><p><strong>Conclusion: </strong>By means of foot and ankle training combined with plantar fascia stress training, it can effectively alleviate the pain of patients with heel fracture and exercise the function of the ankle joint.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Posterior Fixation and Fusion (PFF) versus Combined Anterior and Posterior Fixation and Fusion (CAPFF) for type B and C thoracolumbar spine injuries: a systematic review and meta‑analysis. 纠正:后路固定融合(PFF)与前后路联合固定融合(CAPFF)治疗B型和C型胸腰椎损伤:系统回顾和荟萃分析。
IF 2.8 3区 医学
Journal of Orthopaedic Surgery and Research Pub Date : 2026-04-01 DOI: 10.1186/s13018-026-06716-4
Vincent L Mkochi, Hari Sharma, Alexis G Gonzalez, Hao-Hua Wu
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引用次数: 0
Retraction Note: Psoralen synergizes with exosome-loaded SPC25 to alleviate senescence of nucleus pulposus cells in intervertebral disc degeneration. 注:补骨脂素与载外泌体SPC25协同作用,减轻椎间盘退变时髓核细胞的衰老。
IF 2.8 3区 医学
Journal of Orthopaedic Surgery and Research Pub Date : 2026-03-31 DOI: 10.1186/s13018-026-06826-z
Lei Yang, Zhaoyong Li, Chao Zhang, Shuofu Li, Long Chen, Shaofeng Yang, Yantao Guo
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引用次数: 0
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