Journal of Orthopaedic Surgery and Research最新文献

{"title":"Diagnostic efficacy of nerve root sedimentation sign in post-lumbar interbody fusion patients: an imaging evaluation and modification.","authors":"Jia Chen, Zhikun Xu, Hao Wu, Zhenhua Feng, Fengdong Zhao","doi":"10.1186/s13018-025-05672-9","DOIUrl":"10.1186/s13018-025-05672-9","url":null,"abstract":"<p><strong>Background: </strong>The sedimentation sign offers an efficient method for evaluating lumbar spinal stenosis. However, limited research exists regarding its applicability to post-operative MRI scans. This study aims to assess the viability of utilizing the nerve root sedimentation sign (NRSS) and Schizas classification (SC) in the evaluation of post-operative lumbar stenosis.</p><p><strong>Methods: </strong>Patients were classified into seven groups using SC: A1, A2, A3, A4, B, C and D. The dural sac cross-sectional area (DSCA), anterior-posterior dural sac diameter (AP), and the Oswestry disability index (ODI) of each group were compared. The difference in DSCA between direct and indirect decompression surgery was also compared to confirm whether the deformation of the spinal canal will affect the results.</p><p><strong>Results: </strong>232 postoperative patients were evaluated. The variance of analysis showed that DCSA, AP and ODI had significant differences among the SC groups and NRSS groups postoperatively (P < 0.01). Comparison of DSCA results between direct and indirect decompression postoperative patients showed significant differences between groups A1 and A2, A2 and A3. AP comparison results showed significant differences between groups A1 and A2. ODI comparison results showed significant differences between groups A2 and A3. Among OLIF patients, groups A1 and A2 had mean DSCA values greater than 100mm², while in the T/PLIF group, groups A1-4 had mean DSCA values greater than 100mm².</p><p><strong>Conclusion: </strong>Both sedimentation signs are applicable for the evaluation of postoperative lumbar spinal stenosis. We recommend updating the definition of negative nerve root sedimentation sign to nerve root sedimentation on the dorsal side of the dural sac, with an occupying area less than half, and greater than half considered positive sign. Sedimentation sign is mainly formed by the interaction of gravity, extradural pressure, and nerve root tension.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"258"},"PeriodicalIF":2.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ghrelin increases cis-platinum resistance and promotes aggressiveness of osteosarcoma by activating AKT and Wnt/β-catenin pathways.","authors":"Menglin Cong, Shufeng Li, Yu Fu, Ting Wang, Huizhen Wei, Xiaojie Ma, Fangming Liu, XieHuang Sheng, Kehan Long, Haocheng Hou, Xuecheng Sun, Weiwei Li, Lei Zhang","doi":"10.1186/s13018-024-05261-2","DOIUrl":"10.1186/s13018-024-05261-2","url":null,"abstract":"<p><p>Osteosarcoma (OS) is the most common primary bone malignancy because of its extra high tendency of metastasis. In-depth research is needed to uncover the pathogenesis of patients with OS cells. We collected 74 tissue samples from patients with OS cells and measured the expression levels of ghrelin by immunohistochemistry. Ghrelin was added into OS cell lines in CCK8 assays, JC-1 staining and Western blot analysis were performed to explore its effect on the aggressiveness of OS cells and drug resistance. To determine its function, ghrelin was overexpressed or knocked down in OS cells and then detect cell proliferation in the xenograft mouse model and orthotopic model. Western blot analysis was performed to explore ghrelin-regulated signal pathways. In this work, we identified the relation between the level of ghrelin expression and poor prognosis of OS patients. As well as promoting proliferation, migration, and invation, ghrelin promotes the survival of OS in vitro as well as in vivo, and reduces the apoptosis of OS cells. What's more, ghrelin increases the resistance of cis-platinum by changing mitochondrial function and decreases the expression of MDR-1. Above all, these results demonstrated ghrelin exerts tumorigenic and metastatic effects and may be a potential therapeutic target.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"253"},"PeriodicalIF":2.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injury risk reduction programs including balance training reduce the incidence of anterior cruciate ligament injuries in soccer players: a systematic review and meta-analysis.","authors":"Wenbo Su, Jing Wang, Yuxuan Ying, Bin Lu, Hangbing Liu, Zixiang Zhou, Chang Liu, Hezhang Yun","doi":"10.1186/s13018-025-05639-w","DOIUrl":"10.1186/s13018-025-05639-w","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Anterior cruciate ligament (ACL) injuries are exceedingly common among soccer players and severely impact their careers and health. This study evaluates the effects of injury risk reduction programs, including balance training exercises, on the incidence of ACL injuries in soccer players through a meta-analysis. The aim is to promote the health of soccer players, enhance their athletic performance, and provide valuable insights for further research in the field of sports medicine.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study strictly adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive literature search was conducted through PubMed, EBSCO, and Web of Science databases, covering all entries from the inception of the databases until February 2024.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Eligible studies were individually assessed using the Cochrane Risk of Bias Tool version 2, and the quality of the evidence obtained was rigorously evaluated using the GRADE approach. Data analysis and processing were performed using Stata 18 software. Eight studies were ultimately selected for inclusion in the meta-analysis, encompassing 20,336 participants and 1,512,099 exposure hours, with 190 cases of ACL injuries identified among soccer players. The pooled results indicated that, compared to the control group, groups using injury risk reduction programs that included balance training had a 58% reduction in the overall rate of ACL injuries per 1,000 exposure hours (IRR 0.42, 95% CI: 0.27 to 0.66). The overall study heterogeneity was low, with an I&lt;sup&gt;2&lt;/sup&gt;value of 33.3% and a P-value of 0.186. Subgroup analyses showed that in trials involving male participants, the rate of ACL injuries per 1,000 exposure hours was reduced by 50% compared to the control group (IRR 0.50, 95% CI: 0.29 to 0.88), with an I&lt;sup&gt;2&lt;/sup&gt; value of 44.8% and P = 0.178. In trials involving female participants, ACL injuries were reduced by 61% (IRR 0.39, 95% CI: 0.24 to 0.62), with an I&lt;sup&gt;2&lt;/sup&gt; value of 42.5% and P = 0.157. In trials with participants training less than three times per week, ACL injuries were reduced by 43% per 1,000 exposure hours compared to the control group (IRR 0.57, 95% CI: 0.35 to 0.93), with an I&lt;sup&gt;2&lt;/sup&gt; value of 0.00% and P = 0.727. In trials with participants training three times or more per week, ACL injuries were reduced by 57% (IRR 0.43, 95% CI: 0.21 to 0.88), with an I&lt;sup&gt;2&lt;/sup&gt; value of 28.2% and P = 0.238. In trials with participants training for 20 min or more per week, the rate of ACL injuries per 1,000 exposure hours was reduced by 50% compared to the control group (IRR 0.50, 95% CI: 0.26 to 0.93), with an I&lt;sup&gt;2&lt;/sup&gt; value of 1.2% and P = 0.363. In trials with participants training less than 20 min per week, ACL injuries were reduced by 46% (IRR 0.54, 95% CI: 0.33 to 0.91), with an I&lt;sup&gt;2&lt;/sup&gt; value of 0.00% and P = 0.544.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"248"},"PeriodicalIF":2.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between anterior or posterior femoral head necrosis and collapse based on MRI-defined key necrotic layer sets.","authors":"Yawei Dong, Yan Yan, Jun Zhou, Kaiqiang Tang, Xiaohan Wang, Rui Quan, Jiaming Lin, Yan Jia, Zelu Zheng, Baohong Mi, Weiheng Chen","doi":"10.1186/s13018-025-05633-2","DOIUrl":"10.1186/s13018-025-05633-2","url":null,"abstract":"<p><strong>Background: </strong>Current clinical studies on femoral head necrotic lesions primarily focus on the medial and lateral regions, while detailed MRI-based methods to evaluate the relationship between anterior or posterior necrosis and collapse remain lacking.</p><p><strong>Objective: </strong>By defining the anterior and posterior positions of the femoral head in MRI, a method was proposed for rapid clinical prognosis assessment of femoral head necrosis based on necrotic location.</p><p><strong>Metohd: </strong>A retrospective analysis was conducted on TSE sequence T1W1 coronal plane images from 200 cases of femoral head necrosis. The frequency of necrotic lesions appearing on each MRI layer was statistically analyzed to construct a high-frequency necrotic layer set. Among these cases, 100 hips were randomly selected, and the relationship between femoral head collapse at one-year follow-up and different high-frequency necrotic layer sets was analyzed to identify the key necrotic layer set. Based on this, the anterior and posterior regions of the femoral head were defined on MRI. The remaining 100 hips were used as a validation set to assess the impact of anterior or posterior necrosis of the femoral head, as defined by this method, on collapse.</p><p><strong>Results: </strong>In this study, a total of eight high-frequency necrotic lesion layer sets (S1-S8) were constructed based on MRI data. Among them, S3 (L1 + L2 + L0 + L3) showed the strongest correlation with femoral head collapse, with an AUC of 0.662. Therefore, S3 was defined as the anterior side of the femoral head. Analysis of the validation set revealed that, using this method, the probability of femoral head collapse was 11.4 times higher when necrotic lesions appeared on the anterior side compared to the absence of necrosis on the anterior side.</p><p><strong>Conclusion: </strong>In MRI, the anterior side of the femoral head corresponds to the S3 region, where necrosis increases the risk of collapse by 11.4 times.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"251"},"PeriodicalIF":2.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of exercise prescription in patients with osteoporotic fractures: a systematic review and meta-analysis.","authors":"Mingzhe Yu, Pei Zhou, Yanjun Che, Yuan Luo","doi":"10.1186/s13018-025-05636-z","DOIUrl":"10.1186/s13018-025-05636-z","url":null,"abstract":"<p><strong>Background: </strong>Patients with osteoporotic fractures will further lose bone mineral density and the incidence of refractures will be greatly increased, which is one of the leading causes of death and disability in the elderly. Exercise prescription is effective in enhancing bone strength in patients with osteoporosis, but its effects on patients with osteoporotic fractures have not been systematically reviewed. The purpose of this study is to retrospectively analyze the effect of exercise prescription on bone mineral density in patients with osteoporotic fractures, so as to provide a basis for clinicians to provide postoperative guidance for fracture patients.</p><p><strong>Method: </strong>We searched online databases for published studies on exercise prescription for people with osteoporotic fractures up to September 2024. We included 11 randomized controlled trials that reported the effect of exercise prescription on bone mineral density in people with osteoporotic fractures, and four of these studies reported the effect of exercise prescription on the incidence of refracture in people with osteoporotic fractures. We analysed changes in bone mineral density and incidence of refractures using a fixed-effect model, and meta-regression analyses were performed for subgroups.</p><p><strong>Results: </strong>Of the 701 articles reviewed, we included 11 randomized controlled trials in the meta-analysis. A total of 1101 samples were pooled, including 357 males and 744 females. This study found that exercise prescription was effective in increasing bone mineral density in patients with osteoporotic fractures (MD: 0.07; 95%CI: 0.06 to 0.09), reducing the incidence of refracture by about 3.67 times (OR: 3.67; 95%CI: 1.74 to 7.72). Both whole-body exercise (MD: 0.09; 95% CI: 0.06 to 0.11) and local exercise of the affected limb (MD: 0.06; 95%CI: 0.04 to 0.09) can effectively improve the patient's bone mineral density, and more than 1 year of exercise may be better (MD: 0.10; 95%CI: 0.07 to 0.14).</p><p><strong>Conclusion: </strong>Reasonable exercise prescription can effectively improve bone mineral density and reduce the incidence of refracture in patients with osteoporotic fractures.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"250"},"PeriodicalIF":2.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, bacteriological profile and predictors of surgical site infections following limb amputation at Bugando medical centre and Sekou toure referral regional hospital, Mwanza, Tanzania.","authors":"Haitham Hamudu, Helmut Nyawale, Vitus Silago, Mariam M Mirambo, Phillipo L Chalya, Stephen E Mshana","doi":"10.1186/s13018-025-05638-x","DOIUrl":"10.1186/s13018-025-05638-x","url":null,"abstract":"<p><strong>Background: </strong>Surgical site infections (SSIs) after limb amputations have been associated with increased patient morbidity, mortality and costs. This study aimed to determine the incidence, bacteriological profile and predictors of SSIs following limb amputation at Bugando Medical Centre (BMC) and Sekou Toure Regional Referral Hospital (SRRH).</p><p><strong>Methods: </strong>The longitudinal study was conducted among patients undergoing limb amputations between March and July 2024 at BMC and SRRH. Pre-tested structured questionnaires were used to collect sociodemographic and clinical data. Clinical diagnosis of SSI was done using CDC criteria followed by collection of wound or pus swab for culture and susceptibility testing. Univariate and multivariate logistic regression modelling was done using STATA version 15.0 to assess associations between clinical variables and odds of SSI.</p><p><strong>Results: </strong>A total of 120 patients with a median (IQR) age of 58 [43.5-66.5] years were enrolled. The indications for limb amputations included diabetic foot ulcers (50.8%,61/120), trauma (8.3%,10/120), malignancy (8.3%,10/120), gangrene (9.2%,11/120), peripheral vascular disease (16.7%,20/120) and congenital malformations (6.7%,8/120). The incidence of SSIs was (30%,36/120), with Escherichia coli (36.7%; 11/30) and Staphylococcus aureus (23%; 7/30) being the most frequently isolated pathogens. More than half of the Gram-negative isolates were resistant to third and fourth generations cephalosporins which were commonly used as prophylactic antibiotics in the study settings. Age above 65 years (OR = 0.21, 95% CI: 0.05-0.95, p = 0.043), smoking (OR = 14.3, 95% CI: 1.33-10.00, p = 0.027), ASA Class III (OR = 13.33, 95% CI: 2.82-63.14, p = 0.001), longer surgery duration (≥ 2 h) (OR = 4.09, 95% CI: 1.30-12.89, p = 0.016) and blood transfusion (OR = 2.4, 95% CI: 0.7-8.00, p = 0.02) were independently associated with SSIs.</p><p><strong>Conclusion: </strong>About one third of the patients developed SSIs following limb amputation. Odds of SSIs were increased in patients with low age, smoking, high ASA score, prolonged surgery and who received blood transfusion. This highlighted the need to update the management protocol of limb amputation in relation to antibiotics prophylaxis among patients with increased risk of SSIs based on the local antimicrobial surveillance prevalence data.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"252"},"PeriodicalIF":2.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive model for surgical intervention in pediatric acute hematogenous osteomyelitis.","authors":"Jiale Guo, Wei Feng, Baojian Song, Danjiang Zhu, Yuwei Wen, Qiang Wang","doi":"10.1186/s13018-025-05641-2","DOIUrl":"10.1186/s13018-025-05641-2","url":null,"abstract":"<p><strong>Background: </strong>The emergence of multidrug-resistant bacteria has resulted in more complicated disease courses and worsening prognoses for patients with acute hematogenous osteomyelitis (AHO), increasing the necessity for surgical intervention. This research attempts to identify the risk variables related to surgical patients and build prediction models.</p><p><strong>Method: </strong>From December 2015 to December 2022, children admitted to a single quaternary care pediatric hospital with AHO had their charts retrospectively reviewed. Based on the therapy methods, the patients were divided into 3 cohorts: multiple surgery, single surgery, and conservative care. Multivariate logistic regression analysis was used to identify independent risk factors related to single and recurrent surgery. A nomogram was created to visually represent the various risk factors, and a calibration curve was plotted to evaluate the model's goodness of fit. The Hosmer-Lemeshow test and the area under the receiver operating characteristic (ROC) curve were used to assess how well the models matched.</p><p><strong>Results: </strong>A total of 218 patients were included in the analysis, out of which 150 patients underwent surgical procedures, with 21 individuals undergoing multiple surgeries. The multivariate binary logistic regression revealed that an increase in absolute neutrophil counts (ANC) (adjusted odds ratio [aOR], 1.14 [95% confidence interval {CI}, 1.05-1.24]) and the presence of Methicillin-resistant Staphylococcus aureus (MRSA) (aOR, 6.97 [95% CI, 1.94-25.06]) were strong predictors of surgical intervention. The prediction model demonstrated an area under the curve (AUC) value of 0.76, while the Hosmer-Lemeshow test showed χ² = 7.3, P = 0.50. In another separated model, the C-reactive protein (CRP) level upon admission (aOR, 1.02 [95% CI, 1.00-1.03]) and the CRP level after the initial surgery (aOR, 1.04 [95% CI, 1.01-1.06]) strongly predict multiple surgeries, with the AUC value of 0.91 obtained and HosmerLemeshow test (χ² = 8.7, P = 0.36) yielded. The calibration curves of the two models were drawn separately, and it was observed that the slopes of both models were close to one.</p><p><strong>Conclusion: </strong>Two prediction models were developed by statistical analysis of clinical data. Their accuracy and discrimination were validated, indicating a promising potential for clinical application.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"249"},"PeriodicalIF":2.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of anterior cruciate ligament deficiency severity on the outcomes of fixed-bearing unicompartmental knee arthroplasty: a retrospective study.","authors":"Shuhan Jia, Di Long, Bo Zhang, Mingyang Sun, Fengji Liu, Yixuan Jiao, Guoan Wang, Bin Zhang","doi":"10.1186/s13018-025-05635-0","DOIUrl":"10.1186/s13018-025-05635-0","url":null,"abstract":"<p><strong>Objective: </strong>Anterior cruciate ligament deficiency (ACLD) has traditionally been regarded as a contraindication for unicompartmental knee arthroplasty (UKA). However, advancements in surgical techniques and improvements in prosthetic manufacturing have challenged this notion. Controversy persists regarding whether the anterior cruciate ligament (ACL) influences the postoperative outcomes of fixed-bearing (FB) UKA. This study aimed to evaluate the impact of varying severities of ACLD on the clinical outcomes of FB-UKA.</p><p><strong>Methods: </strong>This retrospective analysis included 81 patients (87 knees) who underwent FB-UKA for anteromedial osteoarthritis (AMOA). Patients were categorised into three groups on the basis of preoperative MRI and intraoperative findings: the intact ACL group (31 knees), the partial ACLD group (39 knees), and the complete ACLD group (17 knees). Patient demographics (age, body mass index [BMI]), preoperative hip-knee-ankle angle (HKA), follow-up duration, and preoperative and last follow-up data, collected more than one year postoperatively, were recorded, including the Hospital for Special Surgery knee score (HSS), Lysholm score, visual analogue scale (VAS) for pain, range of motion (ROM), postoperative X-ray assessment of the position of the femoral component relative to the tibial component, as well as evaluation of radiolucent lines on the postoperative X-rays. Statistical analyses were conducted to determine differences in clinical outcomes, including pre-and postoperative changes, among the three groups. Postoperative complications, such as infection, aseptic loosening, prosthetic dislocation, or periprosthetic fractures requiring revision surgery, were recorded.</p><p><strong>Results: </strong>There were no significant differences among the three groups in terms of age, BMI, follow-up duration, preoperative HKA, baseline Lysholm score, HSS knee score, VAS score, or ROM (P > 0.05). Postoperatively, all three groups showed significant improvements in the Lysholm score, HSS knee score, VAS score, and ROM (P < 0.001), with no significant differences in the extent of improvement among the groups (P > 0.05). The position of the femoral component relative to the tibial component did not differ significantly among the groups (P > 0.05), and no radiolucent lines were observed in any of the patients. No patients experienced complications such as infection, aseptic loosening, periprosthetic fractures, or prosthetic dislocations that required revision surgery at the latest follow-up.</p><p><strong>Conclusion: </strong>FB-UKA is a viable surgical option for the treatment of AMOA. For patients with AMOA and stable anteroposterior knee alignment, ACLD does not adversely affect short- to midterm outcomes following FB-UKA. Even in cases of partial or complete ACLD, careful patient selection and optimised surgical techniques can yield outcomes comparable to those in patients with intact ACLs.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"244"},"PeriodicalIF":2.8,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance evolution of the Nano Boron nitride enhanced bone cement composites.","authors":"Hong Wang, Kangrui Zhang, Wenduo Niu, Sicong Min, Fan Lu, Shifeng Zhang, Wensheng Gao, Hua Han, Yayi Xia","doi":"10.1186/s13018-025-05626-1","DOIUrl":"10.1186/s13018-025-05626-1","url":null,"abstract":"<p><p>Bone cement is a research hotspot and has been partially applied in the field of bone repair thanks to the good mechanical, physical and antibacterial properties. However, the easy wear and high temperature during curing characteristics would cause surrounding tissue necrosis, which seriously limits the wider application to some extent. In this work, the hexagonal boron nitride (h-BN) nano flakes were optimized to enhance the bone cement matrix (PMMA) via mechanical doping. The doping of h-BN into PMMA results in an improved mechanical (bending stress increased by 26%), thermal-conductivity (increased by 175% with the loading of 20 wt%), wear-resistance properties, in addition, the h-BN has no significant impact on cell activity. What's more, the co-modification of PMMA with h-BN and Vancomycin (Va) endows the bone cement composites with more persistent drug release characteristics. This comprehensive performance evolution evaluation provides a reference for the innovative application of modified bone cement.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"245"},"PeriodicalIF":2.8,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and treatment of postoperative voice complications following anterior cervical discectomy and fusion: a systematic review.","authors":"Geena Jung, Jorden Xavier, Shaun Wu, Rachel Schwartz, Rachel Kominsky, Mitchell S Fourman","doi":"10.1186/s13018-025-05464-1","DOIUrl":"10.1186/s13018-025-05464-1","url":null,"abstract":"<p><strong>Background: </strong>There is a wide discrepancy in the literature regarding the incidence of postoperative dysphonia following ACDF. How postoperative dysphonia is measured is also inconsistent, with many studies relying on patient-reported outcomes rather than diagnostic laryngoscopy. The purpose of this study was to consolidate information regarding dysphonia after ACDF to improve diagnosis and management.</p><p><strong>Methods: </strong>A comprehensive database search was performed using key terms. Inclusion criteria was as follows: published within 10 years, subjects > 18 years of age, ACDF for treatment of cervical radiculopathy and/or myelopathy, reports of postoperative changes in voice, and at least one postoperative follow-up between one week and six months. Works that included endoscopic surgical techniques and/or subjects with a history of cancer or trauma to the operated region were excluded. Reviews and meta-analyses were also removed from analysis.</p><p><strong>Results: </strong>Twenty-one eligible studies were analyzed. Evaluation methods varied, with incidence rates ranging from 0.3 to 27%. Symptoms typically arose within one week post-op, persisting up to one year. Treatment modalities included steroids, speech therapy, and laryngoplasty. Mechanisms included recurrent laryngeal nerve injury, endotracheal tube pressure, and postoperative edema.</p><p><strong>Conclusions: </strong>Postoperative voice complications following ACDF represent a clinically significant outcome that can impact a patient's quality of life. Patients should be counseled preoperatively about the potential risk, and managed postoperatively to mitigate long-term impairments. Involvement of otolaryngologists may help prevent these complications or allow for early detection and management, underscoring the importance of multidisciplinary care in optimizing surgical outcomes.</p>","PeriodicalId":16629,"journal":{"name":"Journal of Orthopaedic Surgery and Research","volume":"20 1","pages":"239"},"PeriodicalIF":2.8,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}