Journal of nutritional science and vitaminology最新文献

{"title":"Serum 25-Hydroxyvitamin D Levels and Longitudinal Changes in Muscle Mass and Function in Peritoneal Dialysis Patients: A Prospective Cohort Study.","authors":"Lailiang Wang, Congping Xue, Beixia Zhu, Fangfang Zhou, Qun Luo","doi":"10.3177/jnsv.72.1","DOIUrl":"10.3177/jnsv.72.1","url":null,"abstract":"<p><p>Data regarding to how serum 25 hydroxyvitamin D (25(OH)D) levels affect muscle mass and function in end-stage renal disease (ESRD) patients have led to inconclusive results. The main goal of this research was to examine the relationship between 25(OH)D levels and the risk of deterioration in muscle mass and function among ESRD patients on continuous ambulatory peritoneal dialysis (CAPD). Eligible ESRD patients on CAPD were prospectively included, and followed up at 3-mo intervals in Ningbo No. 2 Hospital, the tertiary care center in the Ningbo region, Zhejiang Province, China for 12 mo. The mean 25(OH)D level <20 ng/mL of all visits during the 12-mo follow-up period was the exposure of interest. Primary outcome was defined as the deterioration of muscle mass and function at the end of the 12-mo follow-up. The absolute difference with 95% confidence interval (CI) of the incidence of deterioration of muscle mass and function between the groups with mean 25(OH)D<20 ng/mL and ≥20 ng/mL were estimated. The relationship between 25(OH)D levels and the risk of deterioration in muscle mass and function was examined by employing multivariate logistic regression models. Participants with 25(OH)D<20 ng/mL or 25(OH)D≥20 ng/mL in each visit were included as a sensitivity analysis. Subgroup analysis was conducted based on the age (<60 y and ≥60 y). Two hundred twenty-one eligible participants were included for the final statistical analysis. Among these 221 participants, patients with the mean 25(OH)D<20 ng/mL was 64.7% (143/221). During the 12-mo follow-up period, the incidence of deterioration in muscle mass and function was 37.6% (83/221). Compared to paticipants with mean 25(OH)D≥20 ng/mL, the incidence in paticipants with mean 25(OH)D<20 ng/mL was significantly higher (46.2% vs 21.8%, p<0.001), with an absolute difference of 24% (95%CI 12-37%). After adjustment for potential confounding factors, mean 25(OH)D<20 ng/mL was still associated with increased risk of the deterioration in muscle mass and function (OR=3.18, 95%CI 1.51-6.70, p=0.002). The association was consistent in the sensitivity analysis (OR=3.22, 95%CI 1.49-6.97, p=0.003). In subgroup analysis, the relationship between mean 25(OH)D<20 ng/mL and the deterioration in muscle mass and function remained consistent (OR=5.59, 95%CI 1.82-17.15, p=0.003) in paticipants with age ≥60 y; however, no significant relationship was identified in patients with age <60 y (OR=2.05, 95%CI 0.72-5.84, p=0.18). Our study demonstrated that lower serum 25(OH)D levels were significantly associated with an increased risk of the deterioration in muscle mass and function in ESRD patients on CAPD, especially in elderly individuals, implicating that vitamin D supplementation might represent an effective way to prevent and treat sarcopenia, frailty and their clinical complications. However, due to inherent limitations in the study, further research is necessary to establish a definitive causal relationship.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 1","pages":"1-8"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147325759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Food Addiction and Its Influencing Factors in Overweight/Obesity Population: A Cross-Sectional Study.","authors":"Yongkang Mao, Yuanyuan Zhou, Nana Li, Xi Wang, Yan Luo, Daomei Cheng, Ju Li, Lingyu Zhong, Yanfeng Zhu","doi":"10.3177/jnsv.72.40","DOIUrl":"10.3177/jnsv.72.40","url":null,"abstract":"<p><p>Obesity represents a major public health challenge with extensive physical and psychological implications. Food addiction (FA), a rising concern linked to obesity, remains insufficiently studied in China. This study investigates the prevalence of FA and identifies factors associated with FA among overweight/obesity. Data were collected between August 2021 and January 2022 from 126 overweight/obesity through structured surveys and questionnaires. Comparative analyses of demographic characteristics, anthropometric indicators, and dietary patterns were performed between participants exhibiting FA symptoms and those without FA. FA symptoms were identified in 43.65% of the participants, with higher prevalence among individuals from the Tibetan population. Subgroup analysis of Tibetan participants revealed that a higher intake of tubers, fats, and sodium was associated with an increased risk of FA, whereas manganese intake may exert a protective effect against FA. Participants with FA showed significantly higher anthropometric measurements, including body mass index (BMI), waist circumference, and body fat percentage, compared to non-FA (NFA) counterparts. Furthermore, a dietary pattern characterized by elevated intake of tubers, fats, energy-dense foods and certain trace elements such as sodium was significantly associated with an increased risk of FA. Overweight/obesity with FA display distinct dietary imbalances, marked by higher BMI and increased consumption of tubers and fats, accompanied by increased intake of specific trace elements. This study is crucial for identifying and evaluating the effectiveness of FA in order to develop targeted interventions and optimise obesity treatment strategies.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 1","pages":"40-52"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Correlation of the Severity of Vascular Calcification with Calcium and Phosphorus Metabolism and Microinflammation in Malnourished Uremic Patients.","authors":"Li Zhang, ChenChen Li, Yan Gao, ZiWen Zhang, Lin Li, Jing Hu, Ling Tian","doi":"10.3177/jnsv.71.148","DOIUrl":"https://doi.org/10.3177/jnsv.71.148","url":null,"abstract":"<p><p>The research assessed calcium (Ca) and phosphorus (P) metabolism and microinflammation in malnourished uremic patients, focusing on the severity of vascular calcification, and examined the relationship between Ca and P metabolism indicators and microinflammation and the severity of vascular calcification. Seventy-eight patients undergoing hemodialysis treatment for ≥6 mo were collected. General information and anthropometric and blood biochemical indices were recorded, including gender, age, body mass index, mid-arm muscle circumference, albumin, intact parathyroid hormone, and Ca and P product (Ca×P). The severity of vascular calcification was graded. The correlation between the severity of vascular calcification in patients and each of the clinical indicators was analyzed. The diagnostic value of Ca and P metabolism and microinflammatory factors for vascular calcification in malnourished uremic patients was assessed. All enrolled patients were divided into a non-vascular calcification group (n=42) and a vascular calcification group (n=36) according to coronary artery calcification (CAC) scoring, and the probability of vascular calcification was 46%. The dialysis duration, Ca×P, P, hypersensitive C-reactive protein (hs-CRP), and interleukin 6 (IL-6) levels were significantly higher in the vascular calcification group than in the non-vascular calcification group. hs-CRP, IL-6, Ca×P, and P had predictive potency for vascular calcification in patients. CAC scores were correlated positively with hs-CRP, IL-6, Ca×P, and P. Malnourished uremic patients have a higher incidence of vascular calcification. hs-CRP, IL-6, Ca×P, and P are all independent risk factors for vascular calcification in uremic patients, and are positively correlated with the severity of vascular calcification.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"148-154"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Dietary Menthol on Autonomic Thermoregulation in a Cold Environment.","authors":"Noriyuki Mori, Masumi Takano, Aya Nakashima, Eriko Inoue, Miki Yanai, Nanako Kondo, Asaka Maikuma","doi":"10.3177/jnsv.71.173","DOIUrl":"https://doi.org/10.3177/jnsv.71.173","url":null,"abstract":"<p><p>Human body temperature homeostasis is regulated by both behavioral and autonomic thermoregulation. The transient receptor potential melastatin 8 (TRPM8) channel, a cold receptor, plays a critical role in cold perception and thermoregulation. Menthol, which activates TRPM8, has been shown to promote the \"browning\" of white adipocytes, enhancing thermogenesis. However, its effect on autonomic thermoregulation has remained unclear. To address this, the present study examines the influence of dietary menthol intake on autonomic thermoregulation in mice, with a focus on body temperature regulation under cold conditions. In this experiment, mice were fed diets containing 0.25% and 0.5% menthol for either 2 or 4 wk. The results indicated that the 0.5% menthol diet significantly reduced food intake, body weight, and visceral fat. In contrast, the 0.25% menthol diet showed no significant impact on these factors. Notably, mice treated with the 0.25% menthol diet for 4 wk suppressed the decrease in rectal and interscapular brown adipose tissue (IBAT) temperatures in a cold environment under anesthesia. Additionally, TRPM8 gene expression in IBAT was upregulated after 4 wk of 0.25% menthol diet consumption. These findings suggest that dietary menthol, especially at low concentrations, improves autonomic thermoregulation by activating TRPM8 without significantly affecting food intake or body weight.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"173-179"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium, Vitamin D, and Dairy Intake and Premenstrual Syndrome: A Cross-Sectional Study.","authors":"Akiko Nanri, Mirai Sakanari, Haruka Mantani, Anri Hirabayashi, Momoka Furuse, Natsuki Yokote, Michi Nakamura, Takashi Takeda, Masanori Ohta","doi":"10.3177/jnsv.71.155","DOIUrl":"https://doi.org/10.3177/jnsv.71.155","url":null,"abstract":"<p><p>Calcium and vitamin D have been suggested to be associated with the amelioration of symptoms of premenstrual syndrome (PMS). However, evidence for an association between the dietary intake of these nutrients and PMS is limited and inconsistent. We examined the cross-sectional association of calcium and vitamin D intake with PMS. Participants were 390 women aged 22-49 y who responded to a mail survey in 2022-2023. Dietary intake was assessed using a validated self-administered diet history questionnaire. PMS were assessed using the Premenstrual Symptoms Questionnaire. Logistic regression analysis was used to estimate odds ratios of PMS according to tertiles of calcium and vitamin D intake with adjustment for potential confounding variables. The prevalence of moderate to severe PMS was 10% (39 women). Neither calcium nor vitamin D intake was significantly associated with PMS. However, calcium intake was associated with a decreased prevalence of PMS, albeit without statistical significance, with multivariable-adjusted odds ratios (95% CI) for PMS in the lowest through highest tertiles of calcium intake of 1.00 (reference), 0.47 (0.18-1.25), and 0.27 (0.07-1.08), respectively (p for trend=0.06). The odds ratio of PMS was low in the highest tertile of vitamin D intake compared with the lowest, but without statistical significance (odds ratio 0.56, 95% CI 0.19-1.66). Our findings suggest that calcium and vitamin D intake was not appreciably associated with PMS. The suggestive inverse association between calcium intake and PMS requires further investigation.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"155-162"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The J-Curve Relationship between Free Carnitine Levels and Cardiovascular Events in Patients with Heart Failure.","authors":"Shingo Watanabe, Junichi Onuma, Michio Usui","doi":"10.3177/jnsv.71.140","DOIUrl":"https://doi.org/10.3177/jnsv.71.140","url":null,"abstract":"<p><p>Hypocarnitinemia is thought to exacerbate heart failure by impairing mitochondrial function and increasing oxidative stress. While some studies suggest that elevated acylcarnitine levels are linked to cardiovascular events, limited data are available on the relationship between free carnitine levels and clinical outcomes in heart failure patients. This study aimed to investigate the association between free carnitine levels and clinical outcomes in patients hospitalized for heart failure. This retrospective study included 271 consecutive patients admitted to our hospital for their first episode of acute heart failure. Patients were divided into four quartiles based on free carnitine levels (quartile 1: <37.0 μmol/L, n=69; quartile 2: 37.0-49.7 μmol/L, n=68; quartile 3: 49.7-58.9 μmol/L, n=67; quartile 4: ≥58.9 μmol/L, n=67). The primary endpoints were 1-y cardiac mortality, rehospitalization due to heart failure, and its composite endpoint. The incidence of cardiovascular events was compared among the quartiles. Creatinine levels were significantly higher in quartile 4 than in other groups. There were no significant differences in age or BNP among the four groups. Additionally, the 1-y mortality rate was significantly higher in both quartile 1 and quartile 4, while the rehospitalization rate for heart failure within 1 y post-discharge was significantly higher in quartile 4. In summary, the relationship between free carnitine levels and mortality in heart failure patients showed a J-curve pattern, with both low and high levels associated with worse outcomes. Thus, extreme free carnitine levels may serve as potential risk factors for adverse clinical outcomes in this population.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"140-147"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Effects of Short-Term Pterostilbene Intake on Healthy Participants: A Pilot Study.","authors":"Kurataka Otsuka, Daisuke Kuriki, Keiko Kamachi, Akira Tanaka, Ryosuke Matsuoka","doi":"10.3177/jnsv.71.70","DOIUrl":"10.3177/jnsv.71.70","url":null,"abstract":"<p><p>Pterostilbene, a polyphenolic compound and an analog of resveratrol, exerts various biological activities and has higher bioavailability and metabolic stability than resveratrol. However, the effectiveness of pterostilbene intake in humans, particularly its effect on blood microRNA (miRNA) expression levels, has not been evaluated. Accordingly, this pilot study aimed to investigate the effects of pterostilbene on blood biochemistry and blood miRNA expression levels and the safety of continuous intake at doses of 10 or 100 mg/d over 12 wk. A double-blind, placebo-controlled parallel-arm comparison trial was conducted with 30 healthy men. In the analysis of blood miRNA expression levels, miR-34a and miR-193b showed very high increases at week 4 and after week 4 of intake, respectively, suggesting that the responders might be present among participants in the pterostilbene intake group. No adverse events were reported during the trial in any participant, and no abnormalities were observed upon examination by the responsible physician. Thus, pterostilbene intake would regulate blood miRNA expression levels, and the results can be utilized in human studies investigating miRNA expression levels with functional food ingredients.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"70-80"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Effects of Short- and Long-Chain Fructans: A Novel Strategy for Mitigating Ovalbumin Allergy via Microbiome-Driven Acetate Production.","authors":"Hideaki Takahashi, Tadashi Fujii, Chikako Yamada, Kotoyo Fujiki, Nobuhiro Kondo, Kento Kuramitsu, Kohei Funasaka, Eizaburo Ohno, Yoshiki Hirooka, Takumi Tochio","doi":"10.3177/jnsv.71.238","DOIUrl":"https://doi.org/10.3177/jnsv.71.238","url":null,"abstract":"<p><p>The gut microbiota has been implicated in the modulation of food allergies. Building on previous studies on the preventive effects of combining short-chain fructan 1-kestose (Kes) and long-chain fructan inulin (Inu) in food allergies, we investigated their therapeutic effects in an ovalbumin (OVA)-induced food allergy mouse model. Following OVA sensitization, the mice received 5% Kes and Inu, either individually or a combined 2.5% dose of each, for 4 wk. We assessed allergy-related markers, such as OVA-specific serum IgE (OVA-sIgE) levels, in the blood and monitored changes in the gut microbiome. The intake of fructans ameliorated allergic symptoms and stabilized rectal temperatures, with a significant reduction in OVA-sIgE levels only in the combined Kes and Inu group (Kes+Inu), p<0.05. Gut microbiota diversity analysis revealed significant differences in beta diversity between the groups not receiving fructans and those receiving Kes, Inu, or Kes+Inu (p<0.01 each). Specifically, in the Kes+Inu group, the abundance of the genus UBA7173 belonging to the family Muribaculaceae significantly increased. Additionally, acetate levels were significantly elevated only in the Kes+Inu group and correlated positively with the presence of the genus UBA7173. These findings indicated that the combined intake of Kes and Inu improves allergic outcomes, positively affects the gut microbiome, and enhances the production of acetate.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 3","pages":"238-247"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Cannabidiol Bioavailability: Development and Evaluation of an Amorphous Cannabidiol Powder Formulation.","authors":"Hiroki Aoyama, Tatsuya Ogawa, Hitomi Ozawa-Umeta, Koji Teshima, Tadashi Hashimoto, Teruyuki Sudo, Kazuki Hashimoto, Takanori Tsuda","doi":"10.3177/jnsv.71.312","DOIUrl":"https://doi.org/10.3177/jnsv.71.312","url":null,"abstract":"<p><p>Despite the various beneficial properties of cannabidiol (CBD), such as antioxidant, anti-inflammatory, analgesic, antidepressant, and anxiolytic activities, its clinical utility is limited due to its notably low bioavailability (BA). To address this issue, we developed an amorphous CBD powder formulation using solvent shift method, which only uses materials approved for food-grade applications. In a pharmacokinetic study in male Sprague-Dawley rats, we orally administered 10 mg/kg of CBD isolate powder with a crystalline structure and our developed amorphous CBD powder formulation. The C_max values demonstrated a 3.9-fold increase for the amorphous CBD powder formulation containing polyvinylpyrrolidone (PVP) as a polymer (F3) and a 3.0-fold increase for the amorphous CBD powder formulation containing hydroxypropyl methylcellulose (HPMC) as a polymer (F4) compared to the CBD isolate powder. Furthermore, the AUC_0-6h values for F3 and F4 were 5.3- and 5.2-fold higher than those for CBD isolate powder, respectively, indicating a significant enhancement. The T_max values were also significantly shorter for F3 and F4, at 0.9±0.1 h and 0.8±0.1 h, respectively, compared to >6.0 h for CBD isolate powder. These findings demonstrate the superior BA of the amorphous CBD formulation. Based on these results, the amorphous CBD formulation is expected to be a highly absorbable CBD formulation, thereby advancing its use in food and supplements.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 4","pages":"312-320"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized Nutritional Rehabilitation Improves Muscle Strength, Cognitive Function, and Quality of Life in Elderly Patients with Sarcopenia and Cognitive Impairment: A Randomized Controlled Trial.","authors":"Zhi Chen, QiaoYi Hu","doi":"10.3177/jnsv.71.507","DOIUrl":"10.3177/jnsv.71.507","url":null,"abstract":"<p><p>Sarcopenia, the progressive loss of muscle mass and strength, greatly affects the elderly. Combined with cognitive impairment, it severely impairs physical function and quality of life. While personalized nutritional rehabilitation programs are proposed, their efficacy remains understudied. To evaluate the effects of individualized nutritional rehabilitation on clinical symptoms and prognosis in elderly patients with sarcopenia and cognitive impairment. This randomized controlled trial enrolled 96 patients with sarcopenia and cognitive impairment (March 2022-March 2023), randomly assigned to intervention (individualized nutritional rehabilitation plus standard care, n=48) or control groups (standard care only, n=48). Assessments included nutritional markers (hemoglobin, albumin, vitamin D), muscle strength (Medical Research Council scale), balance (Berg Balance Scale), physical performance (Short Physical Performance Battery), activities of daily living, grip strength, 5-times sit-to-stand test, 6-m walk speed, cognitive function (Montreal Cognitive Assessment), and quality of life pre- and post-intervention. Post-intervention, the intervention group showed significantly higher hemoglobin, albumin, vitamin D, and lower Patient-Generated Subjective Global Assessment scores (all p<0.05). They demonstrated superior improvements in upper/lower limb strength, Short Physical Performance Battery, Berg Balance Scale, Activities of Daily Living scores, grip strength, sit-to-stand time, and 6-min walk distance (all p<0.05). Montreal Cognitive Assessment scores improved more in the intervention group (25.3±3.2 vs 22.1±3.5, p<0.05). Quality of life improved significantly more in the intervention versus control group (p<0.05). Individualized nutritional rehabilitation effectively improves nutritional status, muscle strength, physical function, cognitive performance, and quality of life in elderly patients with sarcopenia and cognitive impairment.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 6","pages":"507-518"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}