{"title":"The Inverse Association between Alcohol Consumption and Coronary Artery Disease in Japanese Men Undergoing Coronary Angiography.","authors":"Emi Saita, Yoshimi Kishimoto, Reiko Ohmori, Kazuo Kondo, Yukihiko Momiyama","doi":"10.3177/jnsv.71.230","DOIUrl":"https://doi.org/10.3177/jnsv.71.230","url":null,"abstract":"<p><p>Several Japanese cohort studies reported that alcohol consumption was inversely associated with coronary artery disease (CAD). However, these results were inconsistent. We investigated alcohol consumption and CAD in 802 patients undergoing coronary angiography, in whom foods, beverages and alcohol intakes were assessed. Alcohol intake was classified into 4 categories: nondrinkers, light (<23 g/d), moderate (23-45 g/d), and heavy (≥46 g/d) drinkers. Among 583 men, CAD was found in 404, of whom 137 had myocardial infarction (MI). The prevalence of CAD and MI stepwisely decreased on alcohol intake: 80% and 30% in nondrinkers, 65% and 20% in light, 60% and 17% in moderate, and 54% and 16% in heavy drinkers (p<0.001). However, serum γ-GTP levels were higher in heavy drinkers than in nondrinkers. In multivariate analyses, odds ratios for <23 g/d, 23-45 g/d and ≥46 g/d alcohol intakes compared to nondrinkers was 0.53 (95%CI: 0.33-0.85), 0.44 (0.24-0.81), and 0.33 (0.16-0.68) for CAD, and 0.56 (0.34-0.90), 0.62 (0.32-1.20), and 0.43 (0.18-1.01) for MI. Among 219 women, CAD and MI were present in 107 and 36. Compared with nondrinkers, light and moderate to heavy drinkers less often had CAD (52%, 41%, and 29%) and MI (19%, 9%, and 14%), but these differences did not reach statistical significance. In women, no significant association was found between alcohol intake and CAD. Thus, in Japanese men undergoing coronary angiography, alcohol consumption was inversely associated with CAD, but heavy consumption was associated with abnormally high γ-GTP levels. In women, no significant association was found between alcohol consumption and CAD.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 3","pages":"230-237"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cephalotaxus harringtonia and Their Constituents Harringtonine Alkaloids Inhibit FoxO1 and 3a Activity and Atrophy-Related Gene Expression in C2C12 Myotubes.","authors":"Manami Kato, Tomoki Sato, Hiroyuki Fuchino, Hitomi Kawakami, Kayo Yoshimatsu, Kanako Iijima, Shino Hiraoka, Kun Tang, Yasuko Manabe, Nobuharu L Fujii, Yasutomi Kamei, Shinji Miura","doi":"10.3177/jnsv.71.256","DOIUrl":"https://doi.org/10.3177/jnsv.71.256","url":null,"abstract":"<p><p>The expression of the forkhead box O (FoxO) transcription factor, FoxO, in the skeletal muscle is involved in muscle atrophy caused by disuse, fasting, diabetes, and cachexia. Since inhibition of FoxO activity has been shown to be effective in preventing muscle atrophy in genetically engineered animals, inhibition of FoxO activity by dietary components may contribute to the prevention of muscle atrophy. In this study, 4,006 plant extracts were evaluated for FoxO1 and FoxO3a inhibitory activity using a reporter gene assay system, and the extracts from Cephalotaxus harringtonia showed potent inhibitory activities. These extracts also suppressed dexamethasone-induced expression of FoxO target genes, such as atrogin-1 and cathepsin L in C2C12 myotubes. Furthermore, harringtonine alkaloids, harringtonine and homoharringtonine, contained in Cephalotaxus harringtonia inhibited FoxOs activities and suppressed dexamethasone-induced expression of FoxO target genes in C2C12 myotubes, suggesting that harringtonine alkaloids contributed to the effects observed in C2C12 myotubes treated with Cephalotaxus harringtonia extract. However, these extracts and harringtonine alkaloids did not improve weakness in dexamethasone-atrophic myotubes. In conclusion, harringtonine alkaloids from Cephalotaxus harringtonia suppressed FoxO1 and 3a activity and the expression of their target atrophy genes in C2C12 myotubes, but these alkaloids had no the effect on dexamethasone-induced reduction in muscle contractility.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 3","pages":"256-266"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dietary Patterns Rich in Soybean Products, Vegetables, Fish, Fruits, and Miso Soup Were Inversely Associated with Fatty Liver Index: The Nagahama Study.","authors":"Yoko Ueba, Kaori Ikeda, Yasuharu Tabara, Takeo Nakayama, Daisuke Tanaka, Yoshimitsu Takahashi, Shinji Kosugi, Kazuya Setoh, Takahisa Kawaguchi, Fumihiko Matsuda, Nobuya Inagaki","doi":"10.3177/jnsv.71.25","DOIUrl":"10.3177/jnsv.71.25","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prominent liver disease occurring in approximately 25% of the general population. As treatment, lifestyle modification is essential, but there are few reports on dietary patterns associated with MASLD except for the Mediterranean diet. This study examines dietary habits related to MASLD using the fatty liver index (FLI). Longitudinal analysis of a community-based cohort, the Nagahama Prospective Cohort for Comprehensive Human Bioscience, was performed. Dietary habits were assessed by a self-reported questionnaire on food intake frequency, and factor analysis was applied to identify dietary patterns. Multiple regression analysis was performed with baseline FLI or FLI after 5 y as the dependent variable and sex, age, and/or baseline FLI, and factor scores of each dietary pattern as simultaneous independent variables. The same analyses stratified by sex or body mass index (BMI) were also performed. Three thousand five hundred one participants were included. The 15 food items of the questionnaire were summarized into four dietary patterns. Dietary patterns rich in soybean products, vegetables, fish, fruits, and miso soup, which is characteristic of traditional Japanese diet, negatively correlated with FLI and FLI after 5 y (partial regression coefficient: -3.01 and -1.03, respectively; p<0.01 for both). The result was similar in sex-specific analysis and in BMI<23 kg/m<sup>2</sup> group, when the participants were stratified according to BMI. Our results suggest that dietary patterns rich in soybean products, vegetables, fish, fruits, and miso soup are protective factors against MASLD especially in individuals with BMI<23 kg/m<sup>2</sup>.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"25-33"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Relationship between Children's Behavioral Characteristics and Eating Attitudes: A Cross-Sectional Study in Japanese Preschool Children.","authors":"Hiroko Inoue, Yukina Morimoto, Ayako Hashimoto, Ikuko Nagaya, Noriko Kameyama, Kozue Nakamura, Toshiko Kuwano","doi":"10.3177/jnsv.71.192","DOIUrl":"https://doi.org/10.3177/jnsv.71.192","url":null,"abstract":"<p><p>We aimed to clarify the relationship between eating situations and behavioural problems in Japanese preschool children. Subjects were 591 children who attended nursery school in city Y, Japan, and their guardians. We administered a questionnaire that included the children's behavioural characteristics and items pertaining to eating situations, family structure, and guardian's educational background. We analysed the association between eating situations, meal greetings, pleasant mealtime, states of mastication, eating speed, and behavioural problems among preschool children. In these analyses, a Total Difficulty Score (TDS) was used to classify children's behavioural characteristics into two groups, 'Normal' and 'Borderline/Abnormal,' and binomial logistic regression analysis was performed. We calculated the odds ratio (OR) and 95% confidence interval (95% CI) for 'Borderline/Abnormal.' Children who rarely ate breakfast with their families had an adjusted OR of 10.59 for borderline/abnormal TDS compared to children who ate breakfast with their families four or more days a week (p=0.005). Children who chewed only a little at meals had an adjusted OR of 3.25 for borderline/abnormal TDS than children who chewed well. Furthermore, the children who answered that mealtimes were not pleasant mealtime had an adjusted OR of 3.01 for borderline/abnormal TDS than children who always had pleasant mealtime. The results of this study suggested that children's behavioural problems, based on their TDS classification, were related to their eating situations and eating behaviours.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 3","pages":"192-200"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Probiotic Drinks Containing 2,3-Dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one on Cognitive Function of Middle-Aged and Older Individuals.","authors":"Masato Tomizawa, Taiki Sato, Shuichi Segawa, Shin-Ichiro Iio, Tsuyoshi Takara","doi":"10.3177/jnsv.71.223","DOIUrl":"10.3177/jnsv.71.223","url":null,"abstract":"<p><p>The compound 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP) possesses antioxidant properties; however, its effects on cognitive function are unclear. This study examined the effects of DDMP-containing beverages on the cognitive function of healthy middle-aged and older Japanese individuals. We conducted a randomized, double-blind, and placebo-controlled parallel study. The study protocol was registered with the University Hospital Medical Network Clinical Trials Registry (UMIN000052639). In this study, 220 participants who were aware of their memory decline were enrolled and randomly assigned to the intervention or placebo group. The participants ingested the test food [65 mL lactic acid bacteria (LAB) beverage containing 2.2 mg DDMP] or placebo food (65 mL LAB beverage without DDMP) once a day for 12 wk. Cognitive function was assessed before the test and after 12 wk. The primary endpoint was verbal memory, while other cognitive function items and oxidative stress markers were set as the secondary outcomes. Differences in changes among the groups were assessed using analysis of covariance. After 12 wk, verbal and composite memory scores were considerably higher in the DDMP group than in the placebo group. However, no significant differences in oxidative stress markers were noticed. Therefore, consumption of a LAB beverage containing DDMP can markedly improve verbal and composite memory in middle-aged and older individuals with memory deterioration.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 3","pages":"223-229"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Errata.","authors":"","doi":"10.3177/jnsv.71.394","DOIUrl":"https://doi.org/10.3177/jnsv.71.394","url":null,"abstract":"","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 4","pages":"394"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Active Vitamin D Corrects Cerebrovascular Dysfunction and Aberrant Vasopressin Expression in the Hypertension Phenotype of 1α-Hydroxylase Knockout Mice.","authors":"Wei Zhang, Yingying Hu, Luqing Zhang, Ping Dong, Dongmei Li, Ronghui DU","doi":"10.3177/jnsv.71.290","DOIUrl":"https://doi.org/10.3177/jnsv.71.290","url":null,"abstract":"<p><p>Vitamin D has a protective effect on the brain under hypertensive conditions. Studies have shown that 1,25-dihydroxyvitamin D<sub>3</sub> (1,25(OH)<sub>2</sub>D<sub>3</sub>) can negatively regulate hypertension and central renin-angiotensin system activation through a central anti-oxidative mechanism in 1α-hydroxylase knockout mice. To confirm whether endogenous or exogenous 1,25(OH)<sub>2</sub>D<sub>3</sub> deficiency or supplementation alters cerebrovascular function and vasopressin expression through anti-oxidation, researchers provided 1α(OH)ase<sup>-/-</sup> mice and their wild-type littermates with regular diet, a high-calcium, high-phosphorus rescue diet with N-acetyl-L-cysteine supplementation, or 1,25(OH)<sub>2</sub>D<sub>3</sub> subcutaneous injection. The results showed that the hypertension phenotype was present in the 1α(OH)ase<sup>-/-</sup> mice, with upregulated vasopressin expression and increased brain/blood oxidative stress. These pathologic changes were corrected by 1,25(OH)<sub>2</sub>D<sub>3</sub> or N-acetyl-L-cysteine plus rescue diet. The findings suggest that 1,25(OH)<sub>2</sub>D<sub>3</sub> may be a promising protective intervention to reduce brain impairment induced by oxidative stress in the hypertension phenotype of 1α(OH)ase<sup>-/-</sup> mice.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 4","pages":"290-299"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of Dietary Inflammatory Index with Omega-3 Index in Female Athlete.","authors":"Mami Fujibayashi, Akiko Suganuma, Masayuki Domichi, Ikuyo Hayashi, Ryohei Yamakata, Hiroyoshi Fujikawa, Akihito Kumano, Kota Kijima, Sayaka Tomokane, Yukio Ogura, Naoki Sakane","doi":"10.3177/jnsv.71.55","DOIUrl":"10.3177/jnsv.71.55","url":null,"abstract":"<p><p>Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have unique properties that benefit female athletes. No study has examined the association between the dietary inflammatory index (DII) and omega-3 index. Therefore, we investigated the association between the DII and omega-3 index. This cross-sectional study included female university athletes and age- and sex-matched controls. Data were collected from anthropometric assessments, a food frequency questionnaire (FFQ), and blood tests for lipidomics. The energy-adjusted DII was calculated using the FFQ. Seventy-four athletes (mean age=19.7±1.2 y, mean BMI=21.1±2.4) and 38 controls (mean age=20.0±0.9 y, mean BMI=20.3±2.4) were enrolled in the study. The athlete group tended to have a higher percentage of high risk/intermediate in the omega-3 index (75.7% vs. 57.9%; p=0.082) or high-risk category in the trans-fat index (9.5% vs. 0.0%; p=0.093) compared to the control group. The energy-adjusted DII negatively correlated with the omega-3 index, although n-3 PUFA intake did not correlate with the omega-3 index in either group. The present findings indicated that DII might affect omega-3 index independent of n-3 PUFAs intake in female athlete. Health care professionals and coach should consider nutritional interventions based on the omega-3 index rather than relying solely on n-3 PUFAs intake for female athletes.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"55-62"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adding Lemon and n-3 PUFA-Rich Oil to Tomato Juice Preload to a Carbohydrate Meal Ameliorates Early Glycemic and Insulin Responses in Young Healthy Women: A Randomized Crossover Trial.","authors":"Yuki Higuchi, Shizuo Kajiyama, Kaoru Kitta, Takashi Miyawaki, Shinya Matsumoto, Neiko Ozasa, Shintaro Kajiyama, Yoshitaka Hashimoto, Michiaki Fukui, Saeko Imai","doi":"10.3177/jnsv.71.133","DOIUrl":"10.3177/jnsv.71.133","url":null,"abstract":"<p><p>The aim was to evaluate the acute effect of drinking tomato juice preloaded with lemon and perilla oil 10 min before consuming carbohydrate on postprandial blood glucose, insulin, and lipids concentrations in young healthy women. In this randomized controlled crossover study, 21 women (age 21.1±0.6 y, HbA1c 5.2±0.2%, mean±SD) consumed either 200 g of tomato juice, tomato juice with 10 g of lemon juice and 5 g of perilla oil (n-3 PUFA-rich oil), or water 10 min before consuming 200 g of boiled white rice for 3 separate days. The energy and fat in tomato juice with lemon/n-3 PUFA-rich oil were higher (energy 402 kcal, fat 5.6 g) than tomato juice (354 kcal, 0.6 g) and water (315 kcal, 0.6 g). The blood parameters were measured at 0, 30, 60, and 120 min after carbohydrate consumption and compared among 3 d. The plasma glucose at 30 min in tomato juice with lemon/n-3 PUFA-rich oil was significantly lower than that of water (103.1±3.4 mg/dL vs. 127.8±4.0 mg/dL, p<0.001, mean±SE) and tended to be lower than that of tomato juice (113.9±4.9 mg/dL, p=0.078). The serum insulin at 30 min was also significantly lower in tomato juice with lemon/n-3 PUFA-rich oil than that of tomato juice (p<0.01). Adding lemon and n-3 PUFA-rich oil to tomato juice before carbohydrate meal can be practical method to lower early postprandial glucose and insulin responses in young healthy women.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"133-139"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Molecular Mechanisms and Treatment of Cancer-Related Cachexia.","authors":"Yongfei You, Yong Wang, Guohua Zhang, Yong Li","doi":"10.3177/jnsv.71.1","DOIUrl":"10.3177/jnsv.71.1","url":null,"abstract":"<p><p>Cancer cachexia is a multifactorial syndrome characterized by persistent skeletal muscle loss, with or without fat loss, which cannot be completely reversed by traditional nutritional support and leads to impaired organ function. Cachexia seriously reduces the quality of life of (QOL) patients, affects the therapeutic effect against cancers, increases the incidence of complications, and is an important cause of death for patients with advanced cancers. To date, no effective medical intervention has completely reversed cachexia, and no medication has been agreed upon. Here, we describe recent advances in the diagnosis, molecular mechanism and treatment of cancer-related cachexia.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"1-15"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}