Journal of nutritional science and vitaminology最新文献_第2页

Association between the Frequency of the Combined Staple, Main, and Side Dishes Examined Using a Validated Questionnaire and the Intake of Nutrients and Food Groups among Young and Middle-Aged Japanese Adults: Results from the DOSANCO Health Study: A Cross-Sectional Study. 使用有效问卷调查的主食、主食和配菜的组合频率与日本青壮年成年人营养物质和食物种类的摄入量之间的关系：来自DOSANCO健康研究的结果：一项横断面研究。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.201

Akinori Yaegashi, Emiko Okada, Takashi Kimura, Koshi Nakamura, Shigekazu Ukawa, Takafumi Nakagawa, Akihiro Imae, Mami Matsushita, Yukiko Minegishi, Izumi Momose, Mari Shimizu, Junko Suzuki, Chizuru Kubo, Atsuko Yamaguchi, Manabu Musashi, Iwao Ohkubo, Akiko Tamakoshi

{"title":"Association between the Frequency of the Combined Staple, Main, and Side Dishes Examined Using a Validated Questionnaire and the Intake of Nutrients and Food Groups among Young and Middle-Aged Japanese Adults: Results from the DOSANCO Health Study: A Cross-Sectional Study.","authors":"Akinori Yaegashi, Emiko Okada, Takashi Kimura, Koshi Nakamura, Shigekazu Ukawa, Takafumi Nakagawa, Akihiro Imae, Mami Matsushita, Yukiko Minegishi, Izumi Momose, Mari Shimizu, Junko Suzuki, Chizuru Kubo, Atsuko Yamaguchi, Manabu Musashi, Iwao Ohkubo, Akiko Tamakoshi","doi":"10.3177/jnsv.71.201","DOIUrl":"https://doi.org/10.3177/jnsv.71.201","url":null,"abstract":"To clarify the association between the intake frequency of a meal combination of staple, main, and side dishes (SMS meal), determined using a validated questionnaire, and the intake of various nutrients and food groups among Japanese adults. In this cross-sectional study, we analyzed data from 936 persons aged 18-64 y who participated in the Dynamics of Lifestyle and Neighborhood Community on Health Study. The intake frequency of SMS meals was assessed using our validated questionnaire and validated. The intake of nutrients and food groups was examined using validated food-frequency questionnaires. To examine the association of the intake frequency of SMS meals with the intake of specific nutrients and food groups, linear regression analysis was conducted with adjustment for age, body mass index, education history, living status (alone or not), smoking status, and alcohol drinking. The intake frequency of SMS meals was significantly positively associated with the intake of 24/32 nutrients in men, 8/32 nutrients in women, 6/16 food groups in men, and 1/16 food groups in women, and significantly negatively associated with 2/16 food groups in men. A higher intake frequency of SMS meals was not significantly associated with a higher intake of salt or saturated fats. Our results suggest that a higher intake frequency of SMS meals, examined using a validated questionnaire, may be associated with a higher intake of certain nutrients and food groups among young and middle-aged adults without a higher intake of salt and saturated fats.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 3","pages":"201-210"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Amino Acid and Fatty Acid in Seafood, Meat, Beans, and Eggs Using the Food Composition Table. 用食品成分表比较海鲜、肉类、豆类和鸡蛋中的氨基酸和脂肪酸。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.211

Hisami Yamanaka-Okumura, Shiori Yamamoto, Miyu Kenzaka, Sae Nakao, Sari Natsume, Haruka Nishiyama, Miyuki Imafuku, Chika Oue, Yutaka Taketani

{"title":"Comparison of Amino Acid and Fatty Acid in Seafood, Meat, Beans, and Eggs Using the Food Composition Table.","authors":"Hisami Yamanaka-Okumura, Shiori Yamamoto, Miyu Kenzaka, Sae Nakao, Sari Natsume, Haruka Nishiyama, Miyuki Imafuku, Chika Oue, Yutaka Taketani","doi":"10.3177/jnsv.71.211","DOIUrl":"https://doi.org/10.3177/jnsv.71.211","url":null,"abstract":"Nutritional guidance typically uses protein and lipid intake rather than amino acids and fatty acids. However, the composition of amino acids and fatty acids varies depending on the food source, requiring detailed analysis for accurate dietary assessment. Currently, limited research exists on the detailed composition of foods commonly consumed in Japan. Therefore, we aimed to compare the characteristics of amino acid and fatty acid in foods that are the major sources of protein in the Japanese diet. Data cleaning was performed on 2,478 foods listed in the Food Composition Table 2020 (8th revision). Heatmap cluster analysis was performed for food groups, amino acid, and fatty acid, and statistical analysis was performed to determine the percentage differences between food groups. Heat map cluster analysis of the fish and meat data showed that the foods were divided into two groups in the first level (fish and meat). Characteristic amino acid and fatty acid were 5/8 for meat, 1/27 for fish, and 13/0 for common, and no common fatty acid were noted. Significant differences were found between nine amino acids and 31 fatty acids. Heat map cluster analysis using data on seafood, meat, legumes, and eggs showed that foods could be classified into two clusters at the first level: seafood and meat, with legumes and eggs included in the meat cluster. The results of the heat map cluster analysis using statistical analysis and means indicated that seafood, meat, and legumes were characterized differently, especially in terms of fatty acid.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 3","pages":"211-222"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Skipping Breakfast on Academic Performance in Youths: A Meta-Analysis of Observational Studies. 不吃早餐对青少年学业成绩的影响：观察性研究的荟萃分析。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.339

Takahiro Seura, Riko Nagai, Sara Yamazaki, Kenichi Bando, Misako Sogawa

{"title":"The Impact of Skipping Breakfast on Academic Performance in Youths: A Meta-Analysis of Observational Studies.","authors":"Takahiro Seura, Riko Nagai, Sara Yamazaki, Kenichi Bando, Misako Sogawa","doi":"10.3177/jnsv.71.339","DOIUrl":"10.3177/jnsv.71.339","url":null,"abstract":"Academic performance, assessed through tests and assignments, significantly influences long-term outcomes, such as employment, income, and quality of life. Several recent studies have indicated a relationship between skipping breakfast and academic performance; however, no meta-analysis has been performed to explore this association. In the present study, we conducted a meta-analysis of observational studies to synthesize the association between skipping breakfast and academic performance in youths. We perused the literature published before October 2024 using PubMed, Science Direct, Springer Link, and Scopus. We calculated a pooled odds ratio (OR) with 95% confidence interval (95% CI) using a random effects model. The study quality was assessed using the Newcastle-Ottawa Scale adapted for cross-sectional studies. With regard the quality of the included studies, two articles were considered unsatisfactory, five as satisfactory, sixteen as good, and two as very good. After screening, 24 observational studies with 37 reports were included in the meta-analysis. A positive association was observed between skipping breakfast and the risk of poor academic performance (pooled OR=2.08, 95% CI=1.82-2.37). Subgroup analyses based on gender, region, sample size, assessment tools, definition of outcomes, and confounding variables also revealed that skipping breakfast is positively correlated with poor academic performance in youths. In conclusion, this meta-analysis indicates that skipping breakfast is positively associated with poor academic performance in youths.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 4","pages":"339-348"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the Inhibitory Effects of Fatty Acid Derivatives on URAT1 Function, a Renal Urate Re-Absorber. 脂肪酸衍生物对肾尿酸再吸收剂URAT1功能抑制作用的研究。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.331

Yu Toyoda, Hiroki Saito, Hiroshi Hirata, Ami Ota-Kontani, Youichi Tsuchiya, Tappei Takada

{"title":"Investigation of the Inhibitory Effects of Fatty Acid Derivatives on URAT1 Function, a Renal Urate Re-Absorber.","authors":"Yu Toyoda, Hiroki Saito, Hiroshi Hirata, Ami Ota-Kontani, Youichi Tsuchiya, Tappei Takada","doi":"10.3177/jnsv.71.331","DOIUrl":"https://doi.org/10.3177/jnsv.71.331","url":null,"abstract":"The global increase in hyperuricemia, a pathological condition characterized by elevated serum urate concentrations, emphasizes the importance of appropriate management of uric acid homeostasis in the body. Enhancing renal urate excretion is clinically relevant to achieve serum urate-lowering, and the functional inhibition of urate transporter 1 (URAT1), a renal urate transporter involved in the reabsorption of urate, has been recognized as a promising strategy. In this context, natural substances, including food ingredients with URAT1-inhibitory activity, have garnered significant interest. A previous study demonstrated that various fatty acids, including α-linolenic acid (α-LA), inhibit URAT1; however, further investigations are required to expand our understanding for this important topic. The present study focused on certain metabolites derived from α-LA, especially jasmonates (lipid-derived cyclopentanone compounds in plants) and related substances, and investigated their effects on URAT1-mediated urate transport activity, using a mammalian cell-based functional assay system. Among the tested substances (14 authentic chemicals), 12-oxo-phytodienoic acid (a precursor of jasmonic acid harboring a cyclopentenone ring with two carbon chains in its structure) showed a good URAT1-inhibitory activity with the half maximal inhibitory concentration (IC50) value of 15.9 μM. Comparable results were obtained with prostaglandin A1 (PGA1) and PGA2, which are known as cyclopentenone PGs, that exhibited IC50 values of 22.5 μM and 16.8 μM, respectively. Although further studies are required to address the effects of these substances on the urate regulation in humans, our findings contribute to a deeper understanding of the interactions between URAT1 and natural substances.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 4","pages":"331-338"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functions of Coffee Fermented by Rhizopus oligosporus. 寡孢根霉发酵咖啡的功能研究。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.386

Shin Nishiumi, Tatsuo Nakahara, Mei Kimura, Chihiro Fujiwara, Aki Hayakawa, Sara Hosoki, Hana Kato, Karen Kuroki, Miki Nakano, Rikako Sakamoto, Mio Yamaoka

{"title":"Functions of Coffee Fermented by Rhizopus oligosporus.","authors":"Shin Nishiumi, Tatsuo Nakahara, Mei Kimura, Chihiro Fujiwara, Aki Hayakawa, Sara Hosoki, Hana Kato, Karen Kuroki, Miki Nakano, Rikako Sakamoto, Mio Yamaoka","doi":"10.3177/jnsv.71.386","DOIUrl":"https://doi.org/10.3177/jnsv.71.386","url":null,"abstract":"Rhizopus oligosporus (R. oligosporus) is a fungus belonging to the Mucoraceae and is usually used to ferment soybeans in East Asia. R. oligosporus-fermented soybeans are called tempeh and are mainly eaten in East Asia. The recent researches have demonstrated that R. oligosporus can also ferment the beans other than soybeans. In this study, raw coffee beans were fermented with R. oligosporus, and then the effects of coffee prepared from the fermented beans were investigated. The amounts of fats and saccharides were lower in the R. oligosporus-fermented coffee beans than in the unfermented coffee beans, but the amount of dietary fiber was increased in the fermented coffee beans. The R. oligosporus-fermented coffee exhibited decreased total polyphenol levels, and its antioxidant activity was also reduced. However, the concentration of chlorogenic acid, which is one of polyphenols, in the R. oligosporus-fermented coffee was higher than that in the unfermented coffee. In comparison to the unfermented coffee, the R. oligosporus-fermented coffee inhibited α-amylase and α-glucosidase activity more strongly, inhibited cancer growth more weakly or to a similar level, and inhibited H2O2-induced reactive oxygen species production more weakly. The inhibition of α-amylase and α-glycosidase activity is considered to contribute to the prevention of obesity and diabetes. Fermenting raw coffee beans with R. oligosporus may contribute to improving certain effects of coffee, especially the preventative effects against obesity and diabetes.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 4","pages":"386-393"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Phylloquinone Content in 42 Species Algae Inhabiting the Japanese Coast and Relationship between Phylloquinone and Chlorophyll Contents. 日本海岸42种藻类叶绿醌含量评价及与叶绿素含量的关系

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.118

Rina Tanaka, Toshiyuki Shibata, Kosuke Yamamoto, Ryusuke Tanaka

{"title":"Evaluation of Phylloquinone Content in 42 Species Algae Inhabiting the Japanese Coast and Relationship between Phylloquinone and Chlorophyll Contents.","authors":"Rina Tanaka, Toshiyuki Shibata, Kosuke Yamamoto, Ryusuke Tanaka","doi":"10.3177/jnsv.71.118","DOIUrl":"https://doi.org/10.3177/jnsv.71.118","url":null,"abstract":"Terrestrial green plants are rich in phylloquinone (PK), and their PK content is highly correlated with the chlorophyll content. However, there are few studies on the PK content of algae and its correlation with chlorophyll content. To evaluate the PK content in algae and its correlation with chlorophyll, the PK and chlorophyll contents in algae, including Phaeophyta (18 species), Rhodophyta (17 species), and Chlorophyta (seven species), were determined. Algae, particularly Phaeophyta, contain more functional components than do other green terrestrial plants. Therefore, other components such as carotenoids, polyphenols, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability were analyzed to confirm their correlation with PK. Furthermore, terrestrial plants such as leafy vegetables, other vegetables, and tea powder were evaluated for the same components and compared with the experimental results for algae. This results showed that PK was abundant in Phaeophyta and almost all samples contained more than 100 μg/100 g of dry samples. In particular, Sargassum muticum contained 514.11±11.29 μg/100 g. However, almost all of the Rhodophyta and Chlorophyta contained a little PK. The results also confirmed a positive correlation between the PK and chlorophyll content in Rhodophyta (R2=0.7085), Chlorophyta (R2=0.7264), and terrestrial plants (R2=0.8436). However, no correlation was observed between the PK and chlorophyll content in Phaeophyta (R2=0.1013). In addition, the principal component analysis results showed no correlation between PK and other components, such as carotenoids and polyphenols, and DPPH radical scavenging ability in algae. However, Phaeophyta also contained more functional components, such as carotenoids, polyphenols, and DPPH radical scavenging ability than the other algal groups.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"118-132"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural and Functional Characteristics of FMN-Dependent NADPH-Indigo Reductase Homolog from Bacillus cohnii. 玉米芽孢杆菌fmn依赖性nadph -靛蓝还原酶同源物的结构和功能特征。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.180

Kazunari Yoneda, Haruhiko Sakuraba, Junji Hayashi, Yuki Naruse, Tomohiro Araki, Toshihisa Ohshima

引用次数: 0

Brazilian Green Propolis Regulates Thermogenesis via Two Distinct Pathways. 巴西绿蜂胶通过两种不同的途径调节产热。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.375

Takuma Hyodo, Nobuaki Okumura, Takanori Tsuda

{"title":"Brazilian Green Propolis Regulates Thermogenesis via Two Distinct Pathways.","authors":"Takuma Hyodo, Nobuaki Okumura, Takanori Tsuda","doi":"10.3177/jnsv.71.375","DOIUrl":"https://doi.org/10.3177/jnsv.71.375","url":null,"abstract":"Brazilian green propolis (BGP), produced by honey bees, induces beige adipocyte formation and accelerates whole-body energy metabolism. Artepillin C (ArtC), the major cinnamic acid derivative of BGP, induces beige adipocyte formation and increases thermogenesis in inguinal white adipose tissue. However, the effects of BGP on beige adipocyte formation and energy metabolism remain unclear. Therefore, we aimed to examine the effects of BGP on beige adipocyte formation and thermogenesis. We used in vitro and in vivo approaches, such as cell culture and differentiation, component testing, thermogenesis measurement, and calcium influx assay. First, ArtC was confirmed to be a major BGP component contributing to beige adipocyte formation in vitro and in vivo. BGP-induced interscapular brown adipose tissue (iBAT) thermogenesis was not observed upon ArtC stimulation. Thereafter, inhibitory studies revealed that iBAT thermogenesis could be related to the transient receptor potential vanilloid 1 (TRPV1)-sympathetic nervous system channel. Finally, we identified culifolin, a cinnamic acid derivative of BGP, as an active component of this response, which activates calcium signaling in TRPV1-expressing cells. In addition, culifolin administration significantly increased the mouse iBAT temperature to the same extent as increased by BGP. Thus, BGP has a unique biological function in activating the two distinct pathways of brown-adipocyte and beige-adipocyte thermogenesis, contributing to increased energy expenditure.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 4","pages":"375-385"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the Efficacy of Pre-Germinated Brown Rice Extract and γ-Oryzanol against Non-Alcoholic Fatty Liver Disease and Cardiac Complications Induced by a High-Fructose/Fat Diet. 预发芽糙米提取物和γ-谷米醇对高果糖/高脂肪饮食诱导的非酒精性脂肪性肝病和心脏并发症的疗效比较

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.321

Bin-Nan Wu, Hui-Li Lin, Huey-Jen Su, Pei-Wen Cheng, Ya-Mei Chen, Chi-Long Hao, Kuo-Ping Shen

{"title":"Comparison of the Efficacy of Pre-Germinated Brown Rice Extract and γ-Oryzanol against Non-Alcoholic Fatty Liver Disease and Cardiac Complications Induced by a High-Fructose/Fat Diet.","authors":"Bin-Nan Wu, Hui-Li Lin, Huey-Jen Su, Pei-Wen Cheng, Ya-Mei Chen, Chi-Long Hao, Kuo-Ping Shen","doi":"10.3177/jnsv.71.321","DOIUrl":"https://doi.org/10.3177/jnsv.71.321","url":null,"abstract":"This animal experiment aimed to evaluate the efficacy of the extract of pre-germinated brown rice (EP) and γ-oryzanol on non-alcoholic fatty liver disease (NAFLD) and the cardiac complications associated with it. WKY rats were fed high-fructose water (HFW) and high-fat diet (HFD) for 4 wk to induce NAFLD. The other two groups were fed HFW and HFD, while oral administration of EP 200 μL/kg or γ-oryzanol 2 mg/kg every day for 4 wk. NAFLD was successfully induced in as evidenced by clear increases in body, hepatic and cardiac weight as well as by increases in blood pressure and heart rate, hypertriglyceridemia, hyperuricemia, higher liver function index: glutamic pyruvic transaminase (GPT), higher levels of IL-6 and TNF-α in the blood and higher levels TG in the liver. NAFLD rats also had adverse changes the protein expressions of lipid synthesis, inflammation, cardiac fibrosis and hypertrophy. However, when the NAFLD rats were simultaneously fed EP or γ-oryzanol, the development of adverse diet-induced effects, including glutamic oxaloacetic transaminase (GOT), were clearly ameliorated. Specifically, EP could reduce uric acid levels, while γ-oryzanol did not. EP, as well as γ-oryzanol, reversed the increases in levels of lipid synthesis, inflammation, cardiac fibrosis and hypertrophy. We concluded that EP effectively prevented HFW/HFD-induced NAFLD and its associated cardiac complications, which it likely achieved through an improvement of lipid homeostasis and inhibition of inflammation. We believe that EP, like γ-oryzanol, can be developed as a beneficial agent for the prevention and control of NAFLD and associated cardiac dysfunction.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 4","pages":"321-330"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Oligonol^® Supplementation on Abdominal Fat in Japanese Overweight Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study. 寡糖醇®补充剂对日本超重志愿者腹部脂肪的影响：一项随机、双盲、安慰剂对照、平行组研究。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.357

Jun Takanari, Manami Misu, Kazunori Goto, Takuma Shio, Yukiko Fukuchi, Hajime Fujii, Jun Nishihira

{"title":"Effects of Oligonol® Supplementation on Abdominal Fat in Japanese Overweight Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study.","authors":"Jun Takanari, Manami Misu, Kazunori Goto, Takuma Shio, Yukiko Fukuchi, Hajime Fujii, Jun Nishihira","doi":"10.3177/jnsv.71.357","DOIUrl":"https://doi.org/10.3177/jnsv.71.357","url":null,"abstract":"Obesity is known to induce diabetes, hypertension, and dyslipidemia, and reducing obesity is important from the perspective of disease prevention. Oligonol, a standardized oligomerized-polyphenol from Litchi chinensis fruit extract, is expected to have high absorption and body fat reduction. In this study, the effects of Oligonol intake on abdominal fat were examined in overweight Japanese participants. This randomized, double-blind, placebo-controlled trial was performed including 66 overweight adult men and women (body mass index [BMI] of 25 or more and less than 30 kg/m2) who were assigned to receive a daily dose of placebo or 200 mg Oligonol (40 mg as monomers and dimers of flavanols from lychee and tea) for 12 wk. The primary endpoint was a reduction of the visceral fat area (VFA) as quantified by computed tomography scanning after continual intake of test foods for 12 wk. In addition, body weight, BMI, waist circumference, peripheral blood tests, and general urinalysis were performed. Of 66 participants (33 per group), 63 were included in the efficacy analysis (placebo n=32; Oligonol n=31). Intake of 200 mg Oligonol significantly reduced abdominal VFA compared with the placebo group. No clinically relevant adverse events related to the intake of Oligonol were observed. These results indicate that Oligonol had the abdominal visceral fat reduction effect in overweight participants.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 4","pages":"357-365"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0