Journal of nutritional science and vitaminology最新文献

{"title":"Association of Dietary Inflammatory Index with Omega-3 Index in Female Athlete.","authors":"Mami Fujibayashi, Akiko Suganuma, Masayuki Domichi, Ikuyo Hayashi, Ryohei Yamakata, Hiroyoshi Fujikawa, Akihito Kumano, Kota Kijima, Sayaka Tomokane, Yukio Ogura, Naoki Sakane","doi":"10.3177/jnsv.71.55","DOIUrl":"10.3177/jnsv.71.55","url":null,"abstract":"<p><p>Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have unique properties that benefit female athletes. No study has examined the association between the dietary inflammatory index (DII) and omega-3 index. Therefore, we investigated the association between the DII and omega-3 index. This cross-sectional study included female university athletes and age- and sex-matched controls. Data were collected from anthropometric assessments, a food frequency questionnaire (FFQ), and blood tests for lipidomics. The energy-adjusted DII was calculated using the FFQ. Seventy-four athletes (mean age=19.7±1.2 y, mean BMI=21.1±2.4) and 38 controls (mean age=20.0±0.9 y, mean BMI=20.3±2.4) were enrolled in the study. The athlete group tended to have a higher percentage of high risk/intermediate in the omega-3 index (75.7% vs. 57.9%; p=0.082) or high-risk category in the trans-fat index (9.5% vs. 0.0%; p=0.093) compared to the control group. The energy-adjusted DII negatively correlated with the omega-3 index, although n-3 PUFA intake did not correlate with the omega-3 index in either group. The present findings indicated that DII might affect omega-3 index independent of n-3 PUFAs intake in female athlete. Health care professionals and coach should consider nutritional interventions based on the omega-3 index rather than relying solely on n-3 PUFAs intake for female athletes.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"55-62"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adding Lemon and n-3 PUFA-Rich Oil to Tomato Juice Preload to a Carbohydrate Meal Ameliorates Early Glycemic and Insulin Responses in Young Healthy Women: A Randomized Crossover Trial.","authors":"Yuki Higuchi, Shizuo Kajiyama, Kaoru Kitta, Takashi Miyawaki, Shinya Matsumoto, Neiko Ozasa, Shintaro Kajiyama, Yoshitaka Hashimoto, Michiaki Fukui, Saeko Imai","doi":"10.3177/jnsv.71.133","DOIUrl":"10.3177/jnsv.71.133","url":null,"abstract":"<p><p>The aim was to evaluate the acute effect of drinking tomato juice preloaded with lemon and perilla oil 10 min before consuming carbohydrate on postprandial blood glucose, insulin, and lipids concentrations in young healthy women. In this randomized controlled crossover study, 21 women (age 21.1±0.6 y, HbA1c 5.2±0.2%, mean±SD) consumed either 200 g of tomato juice, tomato juice with 10 g of lemon juice and 5 g of perilla oil (n-3 PUFA-rich oil), or water 10 min before consuming 200 g of boiled white rice for 3 separate days. The energy and fat in tomato juice with lemon/n-3 PUFA-rich oil were higher (energy 402 kcal, fat 5.6 g) than tomato juice (354 kcal, 0.6 g) and water (315 kcal, 0.6 g). The blood parameters were measured at 0, 30, 60, and 120 min after carbohydrate consumption and compared among 3 d. The plasma glucose at 30 min in tomato juice with lemon/n-3 PUFA-rich oil was significantly lower than that of water (103.1±3.4 mg/dL vs. 127.8±4.0 mg/dL, p<0.001, mean±SE) and tended to be lower than that of tomato juice (113.9±4.9 mg/dL, p=0.078). The serum insulin at 30 min was also significantly lower in tomato juice with lemon/n-3 PUFA-rich oil than that of tomato juice (p<0.01). Adding lemon and n-3 PUFA-rich oil to tomato juice before carbohydrate meal can be practical method to lower early postprandial glucose and insulin responses in young healthy women.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"133-139"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Molecular Mechanisms and Treatment of Cancer-Related Cachexia.","authors":"Yongfei You, Yong Wang, Guohua Zhang, Yong Li","doi":"10.3177/jnsv.71.1","DOIUrl":"10.3177/jnsv.71.1","url":null,"abstract":"<p><p>Cancer cachexia is a multifactorial syndrome characterized by persistent skeletal muscle loss, with or without fat loss, which cannot be completely reversed by traditional nutritional support and leads to impaired organ function. Cachexia seriously reduces the quality of life of (QOL) patients, affects the therapeutic effect against cancers, increases the incidence of complications, and is an important cause of death for patients with advanced cancers. To date, no effective medical intervention has completely reversed cachexia, and no medication has been agreed upon. Here, we describe recent advances in the diagnosis, molecular mechanism and treatment of cancer-related cachexia.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"1-15"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Excessive Sucrose Intake on Aggressive Behavior and Peripheral Stress-Related Hormone and Catecholamines in BALB/c Mice during Adolescent Development.","authors":"Tohru Miyata, Eichi Nojima, Yuji Minai","doi":"10.3177/jnsv.71.16","DOIUrl":"10.3177/jnsv.71.16","url":null,"abstract":"<p><p>As binge eating and unbalanced diets increase the prevalence of obesity and metabolic disorders, it has been noted that the increase in psychiatric disorders is also a consequence of diet. The present study examined aggressive behavior and peripheral stress-related hormone and catecholamine levels in BALB/c mice fed a high-sucrose diet during adolescent development. BALB/c mice are rarely used in research assessing the effect of diet, but were used for ethnic and personal differences and as a new experimental model. BALB/c mice were fed a diet in which all carbohydrate components were replaced with sucrose for 4 wk and were subjected to the resident-intruder and social dominance tube test. Plasma insulin, corticosterone, and catecholamine levels were also compared to mice fed a control diet. The high-sucrose diet did not alter body weight, glucose tolerance, and plasma insulin levels in BALB/c mice, indicating that the diet was resilient to obesity. Mice fed a high-sucrose diet exhibited increased aggressive behaviors in the resident-intruder test and had a significantly higher win rate in the tube test. Increases in adrenal weight and plasma corticosterone as well as noradrenaline and adrenaline levels were exhibited in mice fed a high-sucrose diet. In particular, this is the first evidence of increased social dominance and hyperplasia of the adrenal glands by a sucrose diet. Sucrose diet intake increased aggression in mice and caused elevated peripheral hormones involving the HPA axis and the sympathetic nervous system, indicating that this may be a central nervous system-mediated effect of excess sucrose.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"16-24"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult Chicken Bone-Derived Components Reverse the Impaired Calcium Homeostasis and Bone Mass in Mice Lacking 1,25(OH)₂D₃-VDR Signaling.","authors":"Tamao Nishiura, Hitoki Yamanaka, Risako Mori, Shigeaki Kato, Masato Nakane, Satoshi Kotoura, Ritsuko Masuyama","doi":"10.3177/jnsv.71.81","DOIUrl":"10.3177/jnsv.71.81","url":null,"abstract":"<p><p>Female adult chickens, known as laying hens, possess a distinctive bone structure in the intracortical region, which is responsible for storing calcium. Given the cyclical nature of calcium storage and demand during the egg-laying cycle, the medullary bone of laying hens plays a crucial role in maintaining calcium homeostasis. In this study, we examined the potential of orally administered components derived from adult chicken bones to improve calcium homeostasis and bone mass in mice. Samples from adult chickens and young chickens without egg-laying experience were prepared by pressing meat parts, including bones, and administered to wild type (WT) and vitamin D receptor knockout (VDRKO) mice respectively. The phenotypes observed in VDRKO mice, such as severe reductions in serum calcium concentration and bone mass, were normalized in mice fed the adult chicken bone-containing diet to the same extent as in WT mice. These effects were not observed in mice fed a young chicken bone-containing diet. The adult chicken bone-containing diet increased apparent calcium absorption in VDRKO mice compared to other dietary groups. To determine the effects on bone metabolism, osteoclasts activity was evaluated by histological measurements and the quantification of serum osteoclast marker, and it was restored by the adult chicken bone-containing diet. In addition, the treatment of adult chicken bone-derived components increased osteoclasts differentiation in vitro from cultured bone marrow macrophage. These results show that adult chicken bone-derived components improve calcium and bone homeostasis in mice lacking vitamin D action through combined effects that target calcium metabolism and bone turnover.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"81-92"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Compound Nutritional Supplement Relieving the Core Symptoms of Autism Rats.","authors":"Xinrong Pan, Yaoyao Xiu, Shiting Huang, Jinjie Lai, Xiaoxue Wang, Xinhui Cao, Liqun Jiang","doi":"10.3177/jnsv.71.34","DOIUrl":"10.3177/jnsv.71.34","url":null,"abstract":"<p><p>Autism, with a global morbidity of approximately 0.6% annually, significantly burdens on families and society. A predominant characteristic among autistic children is intestinal dysfunction, generating nutrient absorption issues. This often causes vitamin and mineral deficiencies, which significantly impacts neurological development. To address this, we have developed a comprehensive nutritional supplement containing compound vitamins, minerals, and gut bacteria. The aim of this study is to investigate the behavioral effects of this supplement on autism rats. The supplement formulated in this study encompasses compound vitamins, minerals, and intestinal bacteria. The autism offspring model (VPA model) was established through intraperitoneal injection of sodium valproate into pregnant rats. Behavioral assessments, gastrointestinal microbiota analysis, and brain development evaluations were conducted to assess the effects of the supplement on VPA offspring rats. A nutritional supplement enriched with vitamins (VB6, VB12, VC, VD, folic acid), minerals (calcium, magnesium), and bifidobacteria was prepared. Open field experiments demonstrated a 3-mo supplementation intervention effectively alleviated anxiety symptoms and enhanced curiosity levels in VPA offspring. The bead embedding experiment revealed the supplementation significantly improved stereotypical behaviors in VPA offspring. The nesting experiment showed a 3-mo supplementation intervention effectively enhanced cognitive abilities in VPA offspring rats. The three-box social experiment demonstrated the supplementation improved social novelty and tendency in VPA offspring. Analysis of gastrointestinal microbiota revealed the supplementation modulated the gut microbiome, promoting better nutrient absorption and overall health. Our findings suggest the comprehensive nutritional supplement, containing compound vitamins, minerals, and gut bacteria, effectively alleviates core symptoms of autism in rats. This study provides valuable insights into the potency of nutritional interventions in improving the quality of life for autistic individuals. Future research is warranted to further explore the mechanisms underlying these observed benefits and to assess the long-term effects of this supplement in larger clinical trials.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"34-45"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Blue Rose Extract Powder Intake on Skin Characteristics in Middle-Aged and Older Japanese Women-Randomized, Double-Blind, and Placebo-Controlled Trial.","authors":"Daisuke Aoyagi, Tomoe Yamada-Kato, Isao Okunishi","doi":"10.3177/jnsv.71.163","DOIUrl":"https://doi.org/10.3177/jnsv.71.163","url":null,"abstract":"<p><p>In this study, we aimed at evaluating the effect of improving skin conditions on petal-derived blue rose extract (BRE) powder intake in middle-aged and older women in Japan. We conducted a randomized, double-blind, and placebo-controlled parallel study in 48 healthy Japanese women aged 40-50 y who were aware of dry skin. We divided the participants equally into two groups (i.e., 24-24 in the test and control groups, respectively). The participants consumed 100 mg either the placebo or BRE powder daily for 4 wk. We performed skin measurements before-and-after 4 wk of continuous intake. Upon 4 wk after continuous intake, the BRE group displayed improved skin quality compared with the control group. The primary outcome was stratum corneum water content, which significantly improved in the BRE group. The secondary outcomes, melanin index, stains, wrinkles, and rough texture showed improvements between the groups as well. Visual perception, roughness of texture, and wrinkles were improved between the groups. Finally, transparency yielded better scores within the groups. This study presents the results of the first functional test targeting BRE, unraveling various effect of improving skin condition and highlighting the potential of taking BRE in skin care.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"163-172"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between the Intakes of Plant Foods and Coronary Artery Disease in Japanese Patients Undergoing Coronary Angiography.","authors":"Emi Saita, Yoshimi Kishimoto, Reiko Ohmori, Kazuo Kondo, Yukihiko Momiyama","doi":"10.3177/jnsv.71.93","DOIUrl":"10.3177/jnsv.71.93","url":null,"abstract":"<p><p>Several Japanese cohort studies have reported that the intakes of plant foods, such as vegetables, fruits, seaweed, and soy products, are inversely associated with coronary artery disease (CAD). However, the results of these studies have been inconsistent. We investigated the association between CAD and the intakes of plant foods in 802 Japanese patients undergoing coronary angiography. The intakes of vegetables, fruits, seaweed, and soy products were determined by 3 categories (<3, 3-4, and >4 times/wk). CAD was found in 511 patients, of whom 173 had myocardial infarction (MI). Patients with higher vegetable and fruit intakes had a significantly lower prevalence of CAD and tended to have a lower prevalence of MI. However, no significant difference was found in the prevalence of CAD or MI among the 3 groups of seaweed and soy product intakes. In the multivariate analyses, the prevalence of CAD decreased depending on the intakes of vegetables and fruits. The odds ratios (OR) for >4 times/wk intakes of vegetables and fruits relative to <3 times/wk were 0.46 (95%CI: 0.29-0.74) and 0.62 (0.40-0.95), respectively. Thus, in Japanese patients undergoing coronary angiography, the intakes of vegetables and fruits were found to be inversely associated with CAD but not with MI. However, no significant association was found between the intakes of seaweed or soy products and CAD or MI.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"93-99"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum 25-Hydroxyvitamin D Levels and the Risk of Post-Traumatic Wound Infection.","authors":"Zhanyi Zhang, Xizhe Yang, Mengyuan Li, Bo Li","doi":"10.3177/jnsv.71.110","DOIUrl":"https://doi.org/10.3177/jnsv.71.110","url":null,"abstract":"<p><p>Post-traumatic wound infection is commonly observed in trauma patients and has a poor prognosis. Vitamin D is a significant modulator of the immune system and may play a role in preventing wound infection. However, the inherent limitations and inconsistent results of previous observational studies restricted them from inferring causal effects. We employed Mendelian randomization design to estimate the causal effects of serum 25-hydroxyvitamin D levels on the risk of post-traumatic wound infection. Data in the analysis were extracted from large-scale genome-wide association studies with 417,580 individuals for serum 25-hydroxyvitamin D measurements and 218,546 individuals for post-traumatic wound infection. Multivariable Mendelian randomization analyses were performed to adjust for confounding variables. We also conducted extensive sensitivity analyses to verify the main results. The results revealed a causal relationship between higher serum 25-hydroxyvitamin D levels and a lower post-traumatic wound infection risk (OR=0.473, p=0.014). The causality remained after adjustment of potential confounding factors according to Multivariable Mendelian randomization analyses (OR=0.361, p<0.001). Sensitivity tests suggested the reliability of our findings. This study indicated a causal association between genetically predicted high serum 25-hydroxyvitamin D levels and a decreased risk of post-traumatic wound infection.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"110-117"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thanks to Reviewers.","authors":"","doi":"10.3177/jnsv.71.184","DOIUrl":"https://doi.org/10.3177/jnsv.71.184","url":null,"abstract":"","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"184"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}