Journal of nutritional science and vitaminology最新文献

{"title":"Relationship between Masticatory Behaviors and Body Mass Index in Healthy Adults Using a Wearable Mastication Counter.","authors":"Arata Tsutsui, Keiichi Ishigami, Takahiro Sakaue, Shinji Togo, Erik-Masao Boller, Tomotaka Takeda, Kazunori Nakajima","doi":"10.3177/jnsv.72.299","DOIUrl":"https://doi.org/10.3177/jnsv.72.299","url":null,"abstract":"<p><p>This study investigated the relationship between masticatory behaviors, masticatory ability, and body mass index (BMI) in healthy adult males and females using a newly developed wearable mastication counter. A total of 106 healthy dentulous participants were included. Assessments during rice ball consumption evaluated mastication frequency, meal duration, mastication speed, masticatory ability, and the presence of fast-eating habits. Statistical analyses compared factors by sex and fast-eating habits and examined the relationships between BMI and these factors, with a 5% significance level. The results showed that BMI was significantly associated with sex, fast-eating habits, and mastication frequency. Females had higher mastication frequency and longer meal durations but mastication speed and lower masticatory ability compared with males. Additionally, participants in the fast-eating group exhibited higher BMI, lower mastication frequency, and shorter meal durations than those in the non-fast-eating group. In conclusion, BMI was associated with sex, fast-eating habit, and mastication frequency in this cross-sectional sample. Further longitudinal or interventional studies are needed to clarify causality.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 4","pages":"299-306"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Fat Fermented Milk Enhanced the Bioavailability of Fat-Soluble Vitamins in Humans: A Crossover Study.","authors":"Masashi Morifuji, Saori Takahashi, Chikaho Sano, Shunsuke Baba, Satomi Ichikawa","doi":"10.3177/jnsv.72.53","DOIUrl":"10.3177/jnsv.72.53","url":null,"abstract":"<p><p>Deficiencies of essential fat-soluble vitamins have been identified in several conditions. Previously we reported the co-ingestion of non-fat fermented milk and vegetables enhanced absorption of carotenoids. Both carotenoids and fat-soluble vitamins have similar absorption mechanisms. Therefore, we hypothesized that the absorption of fat-soluble vitamins may be enhanced when co-ingested with non-fat fermented milk. Twenty healthy male participants were included in this two-group, two-phase crossover study. Participants co-ingested 50 g of a fat-soluble vitamin solution with either 75 g of water or 75 g of non-fat fermented milk before switching after a 2-wk washout. The fat-soluble vitamins were mixed in 50 g of water with 830 μg vitamin A (as retinol), 230 μg of vitamin D (as cholecalciferol), 100.8 mg of vitamin E, and 16.8 mg of vitamin K (as menaquinone-7). Blood samples were collected before and 2, 4, 6, and 8 h after test food consumption and the concentrations of fat-soluble vitamins in the triacylglycerol-rich lipoprotein (TRL) and total plasma fractions were determined. The incremental area under the curve for retinyl palmitate, cholecalciferol, and menaquinone-7 concentrations in the total plasma fraction, and α-tocopherol and γ-tocopherol concentrations in the TRL fraction of plasma were significantly higher for the group of the co-ingestion of fat-soluble vitamins and non-fat fermented milk, compared with the co-ingestion of fat-soluble vitamins and water. Our findings suggest a new nutritional means by which fat-soluble vitamin bioavailability can be enhanced via co-ingestion with non-fat fermented milk. This approach could improve nutritional deficiencies of global health concern.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 1","pages":"53-61"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Energy Intake Assessed by the Food Frequency Questionnaire for Japanese Athletes (FFQJA) Using the Doubly Labeled Water Method.","authors":"Kazuko Ishikawa-Takata, Natsume Osako, Ryoka Suzaki, Norimitsu Kinoshita","doi":"10.3177/jnsv.72.256","DOIUrl":"10.3177/jnsv.72.256","url":null,"abstract":"<p><p>Energy intake assessed using the food frequency questionnaire for Japanese athletes (FFQJA) was evaluated with the doubly labeled water method. The subjects (n=10) were recruited from a male track and field team in one university. The average total energy intake assessed using the FFQJA was 2,662 (standard deviation: 445) kcal, and the average total energy expenditure assessed using the doubly labeled water method was 3,149 (337) kcal. The FFQJA estimate of total energy intake was 486 (897) kcal lower than the total energy expenditure corrected for changes in body weight. A percentage difference between total energy intake and corrected total energy expenditure was -10.3% on average. No significant difference was found between energy intake and corrected energy expenditure. However, Kendall's τ_b and weighted Kappa suggested poor agreement at the individual level. Bland-Altman plot analysis suggested that there was no significant relation between differences in total energy intake and corrected total energy expenditure and average of total energy intake and corrected total energy expenditure (r=-0.493, p=0.147). Because the present study examined only a small number of participants and all of whom were male track and field athletes from the same team, future studies will be needed to clarify the generalizability of these findings.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 3","pages":"256-259"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agaro-Oligosaccharides Modulate Gut Microbiota to Improve Lipid Metabolism in Obesity Model Rats.","authors":"Kento Kuramitsu, Yasuyuki Kitaura, Koji Karasawa, Natasia Hoshiba, Tadashi Fujii, Hideaki Takahashi, Eizaburo Ohno, Kohei Funasaka, Yoshiki Hirooka, Takumi Tochio","doi":"10.3177/jnsv.72.343","DOIUrl":"https://doi.org/10.3177/jnsv.72.343","url":null,"abstract":"<p><p>Obesity is a global health concern, prompting extensive research to identify food components with potential anti-obesity properties. Agaro-oligosaccharides (AOS) have been reported to have anti-obesity effects; however, the precise mechanisms underlying these effects, particularly in relation to the gut microbial metabolites, remain unclear. This study investigated the anti-obesity effects of AOS using Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an established animal model of obesity. Seven-week-old Long-Evans Tokushima Otsuka (LETO) and OLETF rats were fed a control diet or a diet supplemented with AOS for 13 wk. Blood parameters, liver lipids, and gene expression in the liver and ileum were analyzed. Bile acids were evaluated using liquid chromatography-mass spectrometry, and the cecal microbiota was analyzed using 16S rRNA sequencing. AOS supplementation suppressed body weight gain, improved metabolic parameters, and reduced hepatic triglycerides in OLETF rats. AOS supplementation altered bile acids and gut microbiota composition, increasing Akkermansia muciniphila abundance in the cecum. In addition, AOS intake downregulated the expression of lipid synthesis-related genes in the liver and ceramide synthesis-related genes in the ileum. AOS supplementation influences obesity and lipid metabolism by modulating the gut microbiota and bile acid metabolism. Therefore, AOS may help prevent various diseases by improving lipid metabolism.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 4","pages":"343-351"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Early Nutritional Intervention on Clinical Remission Rates and Quality of Life in Newly Diagnosed Inflammatory Bowel Disease Patients.","authors":"Yi Gao, Suqin Xia, Xiaoxue Shen","doi":"10.3177/jnsv.72.30","DOIUrl":"10.3177/jnsv.72.30","url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder influenced by multiple factors including genetic susceptibility, immune dysregulation, environmental triggers, and nutritional status. Nutritional deficiencies are common in IBD patients and may contribute to disease progression and poor clinical outcomes. In this study, we examined how early nutritional intervention affected clinical remission rates, disease activity, and quality of life in newly diagnosed IBD patients. We retrospectively analyzed clinical data from 153 newly diagnosed IBD patients, dividing them into two groups: 78 patients who received early nutritional intervention combined with conventional treatment (intervention group) and 75 patients who received conventional treatment alone (control group). Following treatment periods of 4, 8, 12, and 24 wk, we assessed clinical remission rates, disease activity indices (CDAI for Crohn's disease and Mayo scores for ulcerative colitis), quality of life scores (IBDQ), inflammatory markers, nutritional status, and disease-related complications. Early nutritional intervention led to enhanced clinical remission rates beginning at 8 wk and continuing through 24 wk. Disease activity indices showed progressive improvement in the intervention group, with both CDAI scores in Crohn's disease patients and Mayo scores in ulcerative colitis patients demonstrating notable reductions by the 24-wk assessment. Quality of life scores improved substantially in the intervention group, particularly evident at the 12 and 24-wk time points. Inflammatory markers, including C-reactive protein, erythrocyte sedimentation rate, and fecal calprotectin, exhibited marked decreases in patients receiving nutritional intervention. Nutritional parameters demonstrated improvement in the intervention group, with both serum albumin and prealbumin levels showing restoration toward normal ranges. Additionally, patients in the intervention group experienced lower rates of rehospitalization, extraintestinal complications, and disease relapse during the 24-wk follow-up period. These findings indicate that early nutritional intervention significantly improves clinical outcomes in newly diagnosed IBD patients by enhancing remission rates, reducing disease activity and inflammatory burden, optimizing nutritional status, and decreasing complications. This intervention strategy may represent a valuable therapeutic approach for improving both short-term and long-term prognosis in IBD management.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 1","pages":"30-39"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a Low-Iodine Diet in Post-Thyroidectomy Thyroid Cancer Patients Receiving I-131 Therapy at the Vietnam National Cancer Hospital.","authors":"Bach Viet Hoang, Thuy Thi Tran, Anh Tran Mai LE, Tien Thi Hong Nguyen, Dung Thi Nguyen, Huong Thi LE","doi":"10.3177/jnsv.72.113","DOIUrl":"10.3177/jnsv.72.113","url":null,"abstract":"<p><p>The effects of a low-iodine diet intervention in post-thyroidectomy thyroid cancer patients undergoing radioactive iodine (I-131) therapy has been shown to the improve clinical outcomes of patients worldwide. However, studies evaluating the 24-h dietary intake of low-iodine diets for thyroid cancer patients in Vietnam remain limited. Therefore, we conducted a study to assess the effectiveness of the low-iodine diet and to compare the diet between patients who managed it on their own and those who received guidance from nutrition specialists, with the aim of developing a more effective dietary regimen and monitoring intervention. This was a controlled interventional study comparing two groups: the intervention group received a specialized low-iodine diet designed by a team of experts, while the control group followed the standard hospital low-iodine diet protocol. The effectiveness of the intervention was assessed by measuring urinary iodine concentration and 24-h dietary intake. The mean urinary iodine concentration in the intervention group was lower than in the control group (9.2±3.9 vs. 10.3±3.5 μg/dL), though the difference was not statistically significant (p>0.05). Regarding 24-h dietary intake, the proportion of patients meeting energy and protein requirements was higher in the intervention group (p<0.05). Dietary intake of eicosapentaenoic acid (EPA) was also significantly higher in the intervention group (p<0.05). Nutritional intervention helped ensure adequate energy intake and improved the provision of specific nutrients for patients undergoing I-131 therapy after thyroid cancer surgery.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 2","pages":"113-119"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Appetite, Hunger, and Desired Food Intake of the University Students Belonging to an Athletic Club before and after Practices in Summer and Winter.","authors":"Yusuke Takagi, Yosuke Ogiso, Tadashi Uno, Tetsuya Kita","doi":"10.3177/jnsv.72.182","DOIUrl":"10.3177/jnsv.72.182","url":null,"abstract":"<p><p>The purpose of this study was to evaluate changes in the indices of appetite and hunger before and after the practice among university students of the athletic club in summer and winter. The participants were 16 healthy university female students (age: 19.8±1.3 y) who were members of the university basketball team. The survey was conducted once in July and once in February (2 d total). Basketball practice was held after school on both days (around 5:00 p.m. to 8:00 p.m.). The indices of appetite and hunger were measured immediately before and after practice, 15 and 30 min after practice. The indices of appetite and hunger increased significantly after 15 min of practice in winter, and a significant high positive correlation (r=0.88, p<0.05) was found between the appetite and hunger. On the other hand, the index of hunger in summer showed no significant difference between the immediately after practice and the thereafter. Although a significant positive correlation (r=0.50, p<0.05) was found between the appetite and the hunger, the correlation coefficient was significantly lower than that in winter. No significant differences were found between the seasons for both indices. It is thought that physiological responses to energy expenditure and increased heat dissipation increased appetite and hunger after winter practice among the students. After summer practice, the appetite for cold foods increased, however, there was no significant increase in hunger due to the effect of increased water intake.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 2","pages":"182-188"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alfa-Lipoic Acid and Lipoamide Can Promote Extracellular Coenzyme Q₁₀ Reduction in Presence of Hep G2 Cells; Involvement of Cell-Mediating α-Lipoic Acid- or Lipoamide-Coenzyme Q₁₀ Reduction Cycle.","authors":"Takayuki Takahashi, Tadashi Okamoto","doi":"10.3177/jnsv.72.120","DOIUrl":"10.3177/jnsv.72.120","url":null,"abstract":"<p><p>α-Lipoic acid (LA) and coenzyme Q₁₀ (CoQ₁₀) are frequently taken alone or in combination as dietary supplements with expectations of energy-stimulating effects and antioxidant actions. However, although the amino derivative of LA, α-lipoamide (LA-NH₂), has more powerful biological activities than LA, its clinical use is limited. In the body, most of LA and CoQ₁₀ are in their unstable reduced form, but the reduction mechanisms and interactions between these compounds in the body are not well-understood. Therefore, we investigated their cell-mediated-reductions and interactions between exogenous CoQ₁₀ and LA or LA-NH₂. The reduction of exogenously added CoQ₁₀ was promoted by the co-addition of LA or LA-NH₂ only in the presence of Hep G2 cells, and this promotion was stronger with LA-NH₂ than LA. As a mechanism, we found that exogenous LA and LA-NH₂ were first reduced to their corresponding reduced forms mainly by thioredoxin reductase 1 and lipoamide dehydrogenase, respectively, in cells, and then the reduced forms were rapidly excreted from the cells, where they reduced extracellular CoQ₁₀ to ubiquinol-10 (CoQ₁₀H₂) non-enzymatically. Moreover, it was suggested that exogenous CoQ₁₀ reduction by reduced LA-NH₂ may also occur not only outside but also inside the cells. These results suggest that the combination of LA or LA-NH₂ and CoQ₁₀ can effectively increase the extracellular CoQ₁₀H₂ level in the body. Therefore, it is expected that their combined use will further potentiate the preventive and/or protective effects against various diseases caused by oxidative stress compared with single use, and contribute more effectively to health promotion and anti-aging.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 2","pages":"120-130"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Combination of Oxidative Stress-Induced DNA Damage and NAD⁺ Synthesis Inhibition Induces Synthetic Lethality in A549 Cells.","authors":"Yasuhito Nitta, Masashi Yamamoto, Keisuke Yaku, Hitoshi Uchida, Atsushi Hayashi, Takashi Nakagawa","doi":"10.3177/jnsv.72.131","DOIUrl":"10.3177/jnsv.72.131","url":null,"abstract":"<p><p>Nicotinamide adenine dinucleotide (NAD⁺) is an important coenzyme involved in various redox reactions. Further, NAD⁺ is a substrate for poly-ADP-ribose polymerase (PARP). DNA single-strand break (SSB) induces PARP auto-ADP-ribosylation and recruits DNA repair complex. Oxidative stress, due to hydrogen peroxide (H₂O₂), generally induces SSB DNA damage and depletes NAD⁺ via PARP-mediated poly ADP-ribosylation. A low dose of H₂O₂ treatment induces NAD⁺ depletion but not cell death; therefore, we used it to induce synthetic lethality. After inducing DNA damage in A549 cells, a significant decline in NAD⁺ levels was observed at 1 h after H₂O₂ treatment; however, NAD⁺ levels were restored to normal levels at 24 h after the treatment. Next, we investigated how NAD⁺ was resynthesized after the treatment. In particular, the source of ribose moiety in NAD⁺ was unknown. We used a stable isotope-labeled glucose and identified that phosphoribosyl pyrophosphate (PRPP), the source of the ribose moiety in NAD⁺, originated from glucose and not from ADP-ribose, a degradation product of auto-ADP-ribosylated PARP through NUDT5. Then, we examined whether the NAD⁺ resynthesis inhibition by glucose depletion could induce synthetic lethality with the low-dose H₂O₂ treatment. H₂O₂ treatment or glucose depletion did not induce cell death when used separately; however, a combination of both treatments induces the synthetic lethality in A549 cells. These results signify that a combination of oxidative stress and NAD⁺ synthesis inhibition is an optimal and minimal invasive therapeutic option to induce cell death in cancer cells.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 2","pages":"131-140"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Errata.","authors":"","doi":"10.3177/jnsv.72.84","DOIUrl":"https://doi.org/10.3177/jnsv.72.84","url":null,"abstract":"","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 1","pages":"84"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}