Journal of nutritional science and vitaminology最新文献_第2页

A Combination of Oxidative Stress-Induced DNA Damage and NAD⁺ Synthesis Inhibition Induces Synthetic Lethality in A549 Cells. 氧化应激诱导的DNA损伤和NAD+合成抑制联合诱导A549细胞的合成致死

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2026-01-01 DOI: 10.3177/jnsv.72.131

Yasuhito Nitta, Masashi Yamamoto, Keisuke Yaku, Hitoshi Uchida, Atsushi Hayashi, Takashi Nakagawa

{"title":"A Combination of Oxidative Stress-Induced DNA Damage and NAD+ Synthesis Inhibition Induces Synthetic Lethality in A549 Cells.","authors":"Yasuhito Nitta, Masashi Yamamoto, Keisuke Yaku, Hitoshi Uchida, Atsushi Hayashi, Takashi Nakagawa","doi":"10.3177/jnsv.72.131","DOIUrl":"https://doi.org/10.3177/jnsv.72.131","url":null,"abstract":"Nicotinamide adenine dinucleotide (NAD+) is an important coenzyme involved in various redox reactions. Further, NAD+ is a substrate for poly-ADP-ribose polymerase (PARP). DNA single-strand break (SSB) induces PARP auto-ADP-ribosylation and recruits DNA repair complex. Oxidative stress, due to hydrogen peroxide (H2O2), generally induces SSB DNA damage and depletes NAD+ via PARP-mediated poly ADP-ribosylation. A low dose of H2O2 treatment induces NAD+ depletion but not cell death; therefore, we used it to induce synthetic lethality. After inducing DNA damage in A549 cells, a significant decline in NAD+ levels was observed at 1 h after H2O2 treatment; however, NAD+ levels were restored to normal levels at 24 h after the treatment. Next, we investigated how NAD+ was resynthesized after the treatment. In particular, the source of ribose moiety in NAD+ was unknown. We used a stable isotope-labeled glucose and identified that phosphoribosyl pyrophosphate (PRPP), the source of the ribose moiety in NAD+, originated from glucose and not from ADP-ribose, a degradation product of auto-ADP-ribosylated PARP through NUDT5. Then, we examined whether the NAD+ resynthesis inhibition by glucose depletion could induce synthetic lethality with the low-dose H2O2 treatment. H2O2 treatment or glucose depletion did not induce cell death when used separately; however, a combination of both treatments induces the synthetic lethality in A549 cells. These results signify that a combination of oxidative stress and NAD+ synthesis inhibition is an optimal and minimal invasive therapeutic option to induce cell death in cancer cells.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 2","pages":"131-140"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of the Rice Endosperm Protein Hydrolysate B on Appetite in Healthy Japanese Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. 水稻胚乳蛋白水解物B对日本健康受试者食欲的影响：一项随机、双盲、安慰剂对照的临床试验

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2026-01-01 DOI: 10.3177/jnsv.72.76

Natsumi Taira, Toshihiro Mihara, Yuki Higuchi, Hajime Takahashi, Masaru Sato, Kousaku Ohinata

{"title":"The Effect of the Rice Endosperm Protein Hydrolysate B on Appetite in Healthy Japanese Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.","authors":"Natsumi Taira, Toshihiro Mihara, Yuki Higuchi, Hajime Takahashi, Masaru Sato, Kousaku Ohinata","doi":"10.3177/jnsv.72.76","DOIUrl":"10.3177/jnsv.72.76","url":null,"abstract":"Rice endosperm protein hydrolysate B (REPH-B) is produced by enzymatic degradation of rice endosperm protein. REPH-B contains the following peptides: QAFEPIRSV, pEAFEPIRSV, and TNPWHSPRQGSF. A previous study reported that REPH-B has the ability to induce plasma acylated ghrelin secretion and increase food intake in animal models. In this study, we investigated the effect of REPH-B on appetite in healthy adults aged over 40 y who had a relatively low visual analogue scale (VAS) score for hunger. Forty-six healthy subjects who were aware that their appetite had decreased were enrolled. Subjects were randomly allocated to one of two groups. The influence of REPH-B on appetite was evaluated by VAS under two conditions: repeated intake over 2 wk (Study 1) and single intake (Study 2). Though a single intake of REPH-B had no influence on any of the parameters evaluated, repeated intake of REPH-B significantly improved the VAS score for hunger. In conclusion, repeated intake of REPH-B might increase hunger in healthy adults who suffer from a lack of appetite. This study was registered with UMIN Clinical Trials Registry as UMIN000049108.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 1","pages":"76-83"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147325696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Consuming a Docosahexaenoic Acid-Enriched Milk Beverage on the Erythrocyte Omega-3 Index and Stress Index in Healthy Japanese Schoolchildren Aged 12 to 15 Years. 饮用富含二十二碳六烯酸的牛奶饮料对日本12 ~ 15岁健康学童红细胞Omega-3指数和应激指数的影响

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2026-01-01 DOI: 10.3177/jnsv.72.189

Takashi Ichinose, Nobuhiko Tachibana, Kentaro Matsuzaki, Arata Hashimoto, Eiji Iwaoka, Setsushi Kato, Shuzo Ohata, Miho Ohno, Atsushi Nagai, Michio Hashimoto

{"title":"Effects of Consuming a Docosahexaenoic Acid-Enriched Milk Beverage on the Erythrocyte Omega-3 Index and Stress Index in Healthy Japanese Schoolchildren Aged 12 to 15 Years.","authors":"Takashi Ichinose, Nobuhiko Tachibana, Kentaro Matsuzaki, Arata Hashimoto, Eiji Iwaoka, Setsushi Kato, Shuzo Ohata, Miho Ohno, Atsushi Nagai, Michio Hashimoto","doi":"10.3177/jnsv.72.189","DOIUrl":"https://doi.org/10.3177/jnsv.72.189","url":null,"abstract":"Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are polyunsaturated fatty acids that are essential to human health. DHA in particular plays an important role in the development and maintenance of the brain. As seafood consumption has decreased sharply in Japan, concerns have grown about brain growth and development in infants and school-aged children. It is therefore critical to investigate the effects of DHA/EPA intake on the brain functions of school-aged children. The International Society for the Study of Fatty Acids and Lipids has proposed the erythrocyte omega-3 index as the standard measure of omega-3 fatty acid uptake. In this pilot study, we investigated the effects of consuming a DHA-enriched milk beverage fortified with 297 mg DHA and 137 mg EPA on the erythrocyte omega-3 and stress indices in schoolchildren. Intake of the DHA-enriched milk beverage for 12 wk led to an increase in the erythrocyte omega-3 index from 6.46% to 7.67% in children aged 12 to 15 y. Moreover, it led to a significant decrease in the \"helplessness\" score, which is an item on the stress response scale. These results suggest that daily intake of DHA, even in low amounts, could alleviate stress in school-aged children, potentially preventing various problematic behaviors.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 2","pages":"189-195"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Verification of the Effect of Heat-Killed Saccharomyces cerevisiae PA YEAST SC-1 on the Gut Environment: A Culture Study Using Human Feces and a Randomized, Double-Blind, Placebo-Controlled Crossover Trial in Healthy Adults. 热杀酿酒酵母PA酵母SC-1对肠道环境影响的验证：人类粪便培养研究和健康成人随机、双盲、安慰剂对照交叉试验

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2026-01-01 DOI: 10.3177/jnsv.72.141

Junichi Node, Yosuke Kikuchi, Kento Kurihara, Yuka Togashi, Michihiro Sakakibara, Katsuhiro Miyajima, Shukuko Ebihara

{"title":"Verification of the Effect of Heat-Killed Saccharomyces cerevisiae PA YEAST SC-1 on the Gut Environment: A Culture Study Using Human Feces and a Randomized, Double-Blind, Placebo-Controlled Crossover Trial in Healthy Adults.","authors":"Junichi Node, Yosuke Kikuchi, Kento Kurihara, Yuka Togashi, Michihiro Sakakibara, Katsuhiro Miyajima, Shukuko Ebihara","doi":"10.3177/jnsv.72.141","DOIUrl":"https://doi.org/10.3177/jnsv.72.141","url":null,"abstract":"To test the efficacy of heat-killed Saccharomyces cerevisiae PA YEAST SC-1 (PA YEAST SC-1) in improving the gut environment, we conducted a culture study using feces from healthy adults and a randomized double-blind placebo-controlled crossover controlled trial in healthy adults. In human clinical trials, the gut microbiota was used as the primary endpoint and defecation status, fecal physicochemical tests, blood immune system tests, Constipation Assessment Scale-middle term (CAS-MT), and clinical laboratory values were measured as secondary endpoints. Culture tests showed that adding PA YEAST SC-1 substantially increased acetic acid and propionic acid levels. In a human clinical trial, PA YEAST SC-1 intake significantly increased the occupancy of short-chain fatty acid-producing bacteria (such as Parabacteroides genus), while propionic acid and the total amount of short-chain fatty acids tended to increase. Phenol, skatole, and fecal pH levels were significantly reduced. These studies indicate that PA YEAST SC-1 was utilized by the human gut bacteria and influenced the gut microbiota and metabolites, improving the gut environment.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 2","pages":"141-153"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sedentary Behaviour and Free-Living Physical Activity Intensity as Determinants of Physical Activity Level in Young Adult Women without Regular Exercise Habits. 久坐行为和自由生活体力活动强度是没有规律运动习惯的年轻成年女性体力活动水平的决定因素。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2026-01-01 DOI: 10.3177/jnsv.72.9

Hibiki Aikawa, Yoichi Hatamoto, Eiichi Yoshimura, Takuro Tobina, Makoto Ayabe, Hideaki Kumahara

{"title":"Sedentary Behaviour and Free-Living Physical Activity Intensity as Determinants of Physical Activity Level in Young Adult Women without Regular Exercise Habits.","authors":"Hibiki Aikawa, Yoichi Hatamoto, Eiichi Yoshimura, Takuro Tobina, Makoto Ayabe, Hideaki Kumahara","doi":"10.3177/jnsv.72.9","DOIUrl":"10.3177/jnsv.72.9","url":null,"abstract":"There is a growing amount of research on the association of physical activity level (PAL) and physical activity-related energy expenditure (PAEE) with physical activity (PA) intensity or body composition variables; however, the age of the target population, especially young adults, is limited. In this study, we aimed to investigate the association between PA indices such as each PA intensity, including sedentary behaviour (SB), and free-living energy expenditure using the doubly labelled water (DLW) method. Using the DLW method under free-living conditions, total energy expenditure was evaluated in 32 healthy women without regular exercise habits in their 20 s. PA, including the percentage of time spent engaging in light, moderate, and vigorous physical intensities, was measured using a validated accelerometer. The %SB was also calculated. Partial correlation coefficients of the relationship between the PAL and PA variables, including sleeping time, age, and body composition indices, were calculated while controlling for the effect of multiple variables. PAEE normalised for body weight (PAEE/kg) and average PAL were 10.2±3.0 kcal/kg/d (42.7±12.7 kJ/kg/d) and 1.60±0.17, respectively. PAL and PAEE/kg had significant negative partial correlations with %SB (r=-0.428, p=0.033 and r=-0.484, p=0.014, respectively). The results indicate that reducing SB attributes to higher values of PAL and PAEE/kg. This is the first study to clarify the contribution of SB and other PA indices to the intensity of PAL and free-living energy expenditure using DLW in young adult women without regular exercise habits.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 1","pages":"9-18"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Paramyosin as a Novel Allergen in Edible Cricket Protein. 食用蟋蟀蛋白中新过敏原副肌球蛋白的鉴定。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2026-01-01 DOI: 10.3177/jnsv.72.70

Minami Nakamura, Hiroki Matsuki, Kanon Hagiwara, Saki Okuno, Kosuke Kataoka, Seiya Ashikari, Kensuke Ikeda, Katsuyuki Miyawaki, Takahito Watanabe, Shintaro Inoue, Taro Mito, Toru Asahi, Akira Takahashi, Takayuki Uchida, Takeshi Nikawa

{"title":"Identification of Paramyosin as a Novel Allergen in Edible Cricket Protein.","authors":"Minami Nakamura, Hiroki Matsuki, Kanon Hagiwara, Saki Okuno, Kosuke Kataoka, Seiya Ashikari, Kensuke Ikeda, Katsuyuki Miyawaki, Takahito Watanabe, Shintaro Inoue, Taro Mito, Toru Asahi, Akira Takahashi, Takayuki Uchida, Takeshi Nikawa","doi":"10.3177/jnsv.72.70","DOIUrl":"10.3177/jnsv.72.70","url":null,"abstract":"Edible insects have recently gained attention as a sustainable protein source. In a dietary intervention clinical trial, participants consumed one of the following for 28 d: wheat bread, soy protein bread, cricket protein bread, or a mixed bread containing both cricket and soy proteins. Although individuals with known allergies to soy, crustaceans, or wheat were excluded, several participants developed allergic dermatitis (erythema with itching) after consuming cricket protein bread. This study, therefore, aims to identify potential allergens in cricket protein that may have triggered these reactions. To do so, we analyzed serum samples from an individual who developed allergic dermatitis after consuming the cricket protein or cricket-soy protein mixed bread. Our results revealed a novel allergen candidate. In contrast, this allergen was not detected in serum from an individual who consumed the same bread but did not experience an allergic reaction. The newly identified allergen was solubilized by heating at 95ºC for 5 min in 10% SDS. Using liquid chromatography-mass spectrometry (LC-MS/MS) and database searches in the National Center for Biotechnology Information (NCBI) Gryllus protein database, paramyosin was identified as a candidate protein. Our findings suggest a new allergen candidate in cricket protein, which is regarded as a promising alternative protein source and edible insect. Furthermore, these results support the safety assessment of cricket consumption and underscore the importance of allergen screening in edible crickets.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 1","pages":"70-75"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between Diet and Training: Impact on Blood ALT and γ-GTP Levels in Heavyweight Male Athletes. 饮食与训练的相关性：对重量级男运动员血液ALT和γ-GTP水平的影响。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2026-01-01 DOI: 10.3177/jnsv.72.19

Yukika Yoshizawa, Megumi Matsumoto, Jun Konno, Hidehiko Kushi

{"title":"Correlation between Diet and Training: Impact on Blood ALT and γ-GTP Levels in Heavyweight Male Athletes.","authors":"Yukika Yoshizawa, Megumi Matsumoto, Jun Konno, Hidehiko Kushi","doi":"10.3177/jnsv.72.19","DOIUrl":"10.3177/jnsv.72.19","url":null,"abstract":"Some heavyweight athletes like track and field throwing and heavyweight judo, have high levels of visceral fat, which raises concerns about develop reduced liver function. This study presents a detailed analysis of the relationships among dietary intake, physical activity, and factors that exacerbate blood test results in these athletes. The study involved 20 track and field throwers (TF) and 9 judo heavyweight athletes (JH). We conducted body composition measurements using the impedance method, a training survey, and a semi-quantitative diet survey over 3 d. We performed blood tests to determine the effects of dietary intake and training on liver function. Blood tests revealed alanine aminotransferase (ALT) and γ-glutamyl transpeptidase (γ-GTP) levels of 33±3 and 22±2 U/L in the TF, and 28±5 and 25±2 U/L in the JH. Daily energy intake and exercise energy expenditure were 3,018±149 and 884±71 kcal/d in the TF, and 3,160±146 and 1,593±153 kcal/d in the JH, respectively. We found positive correlations among weight, carbohydrate intake and energy ratio, ALT levels, and γ-GTP levels in both groups. While decreased liver function is traditionally addressed by discontinuing training, this study suggests that dietary adjustments may also be necessary.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 1","pages":"19-29"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the Value of Serum TG/HDL-C Ratio Combined with Controlling Nutritional Status Score in Assessing Lesion Severity and Short-Term Prognosis in Patients with Coronary Atherosclerosis. 血清TG/HDL-C比值结合控制营养状态评分评价冠状动脉粥样硬化患者病变严重程度及短期预后的价值分析

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2026-01-01 DOI: 10.3177/jnsv.72.85

ChunYan Wang, Dong Liu, YiJia Ma, JinDa Liu, LiQiang Zhou

{"title":"Analysis of the Value of Serum TG/HDL-C Ratio Combined with Controlling Nutritional Status Score in Assessing Lesion Severity and Short-Term Prognosis in Patients with Coronary Atherosclerosis.","authors":"ChunYan Wang, Dong Liu, YiJia Ma, JinDa Liu, LiQiang Zhou","doi":"10.3177/jnsv.72.85","DOIUrl":"https://doi.org/10.3177/jnsv.72.85","url":null,"abstract":"Coronary artery disease (CAD) remains one of the leading causes of death worldwide. This study aimed to evaluate the predictive value of combining the serum to high-density lipoprotein cholesterol ratio (TG/HDL-C) with the Controlling Nutritional Status (CONUT) score for assessing lesion severity and short-term prognosis in CAD patients. A total of 138 patients undergoing their first coronary angiography were enrolled and divided into CAD (n=88) and non-CAD (n=50) groups. Baseline characteristics and laboratory parameters were collected, and TG/HDL-C ratio and CONUT score were calculated. Lesion severity was assessed using the Gensini score, and CAD patients were followed for 6 mo. Multivariate logistic regression was performed to identify independent risk factors, evaluated the predictive performance. Both TG/HDL-C ratio (odds ratio [OR]=3.58) and CONUT score (OR=1.70) were independent predictors of CAD severity and showed significant positive correlations with Gensini scores. ROC analysis demonstrated that the combined model of TG/HDL-C and CONUT score achieved an area under the curve (AUC) of 0.86 for predicting CAD severity, outperforming individual markers. The combined model also exhibited stable predictive value for short-term prognosis (AUC=0.80). Serum TG/HDL-C ratio and CONUT score are independent and effective biomarkers for evaluating lesion severity and short-term prognosis in CAD patients. The combined predictive model enhances accuracy and may serve as a clinical tool for risk assessment and intervention decisions.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 2","pages":"85-92"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Food Restriction Impairs Exercise-Induced Bone Mass Acquisition and Causes Iron Metabolic Disturbance with Storage Depletion in Young Female Rats. 在年轻雌性大鼠中，食物限制损害运动诱导的骨量获取并引起铁代谢紊乱和储存损耗。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2026-01-01 DOI: 10.3177/jnsv.72.101

Kazuki Kioka, Yuki Aikawa, Kota Noboritate, Hayata Yamamoto, Kaya Sugiyama, Hana Shingu, Kyosuke Watanabe, Hirotaka Suzuki, Naomi Omi

{"title":"Food Restriction Impairs Exercise-Induced Bone Mass Acquisition and Causes Iron Metabolic Disturbance with Storage Depletion in Young Female Rats.","authors":"Kazuki Kioka, Yuki Aikawa, Kota Noboritate, Hayata Yamamoto, Kaya Sugiyama, Hana Shingu, Kyosuke Watanabe, Hirotaka Suzuki, Naomi Omi","doi":"10.3177/jnsv.72.101","DOIUrl":"https://doi.org/10.3177/jnsv.72.101","url":null,"abstract":"Low energy availability is a core feature of Relative Energy Deficiency in Sport that impairs skeletal and hematologic health. However, the contributions of short-term energy restriction and exercise as well as their potential interactive effects remain unclear. This study aimed to clarify the effects of short-term food restriction on exercise-induced bone mass acquisition and its simultaneous impact on iron metabolism in young female rats. Female Sprague-Dawley rats (5 wk old) underwent environmental acclimation and treadmill running exercise training for 1 wk each and randomly grouped into seven groups. The groups included a sedentary and ad libitum feeding group, along with groups fed 90%, 70%, or 50% of the average ad-lib intake under sedentary or running exercise conditions for 15 d. The results showed low tibial bone mineral density (BMD) and ferritin levels and high serum iron levels due to a significant main effect of food restriction. Hematocrit-adjusted erythrocyte counts were unchanged, indicating an iron metabolic disturbance characterized by depleted stores despite high circulating iron. Exercise significantly increased tibial BMD, but the 50% food restriction groups (sedentary and exercise) showed significantly lower values than the exercise 90% group. Serum iron levels showed significant differences even in the 70% food restriction group compared with the 90% group. Tibial BMD and serum iron levels were weakly negatively correlated. This study revealed that, in young female rats, short-term 50% food restriction resulted in decreased BMD while short-term 70% and 50% food restriction resulted in iron metabolic disturbances under both sedentary and exercise conditions.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 2","pages":"101-112"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective Eating Behavior and Delayed Bedtime in Children Aged 3-6 Years: The Mediating Role of Breakfast Tryptophan Intake. 3-6岁儿童选择性饮食行为与延迟就寝：早餐色氨酸摄入量的中介作用。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2026-01-01 DOI: 10.3177/jnsv.72.62

Naoki Sakane, Yaeko Kawaguchi, Junichiro Somei, Akiko Suganuma, Masayuki Domichi

{"title":"Selective Eating Behavior and Delayed Bedtime in Children Aged 3-6 Years: The Mediating Role of Breakfast Tryptophan Intake.","authors":"Naoki Sakane, Yaeko Kawaguchi, Junichiro Somei, Akiko Suganuma, Masayuki Domichi","doi":"10.3177/jnsv.72.62","DOIUrl":"10.3177/jnsv.72.62","url":null,"abstract":"Mealtime behaviors may influence sleep patterns in preschool children; however, this relationship remains unclear. This study aimed to clarify which mealtime behaviors affect sleep among preschool children. A total of 283 children aged 3-6 y were included in this study. Problematic mealtime behaviors-such as selective eating, clumsiness/manners, interest and concentration in eating, oral motor function, and overeating-were assessed. Data on wake-up time, bedtime, total sleep duration, and sleep midpoint were collected. The tryptophan index (Trp index) was calculated at breakfast. A mediation analysis, controlling for age in month and sex, was conducted under the assumption of a causal pathway from selective eating behavior to bedtime via the Trp index. The analysis estimated both direct and indirect effects. Compared to the non-selective eating behavior group (n=121), the selective eating behavior group (n=162) exhibited later wake-up times (6:44±0:28 vs. 6:52±0:32; p=0.043), later bedtimes (21:15±0:37 vs. 21:33±0:33; p<0.001), later midpoints of sleep (2:00±0:27 vs. 2:13±0:31; p<0.001), shorter total sleep (9.5±0.6 vs. 9.3±0.7 h; p=0.018), and a lower Trp-index (285±167 vs. 234±149; p=0.007). Selective eating behavior was associated with lower tryptophan intake at breakfast, which in turn was linked to later bedtimes. The mediation analysis showed that tryptophan intake partially mediated the relationship between selective eating behavior and sleep timing (proportion mediated=13.6%). These findings suggests that a significant association was observed between selective eating behavior and poor sleep habits, and tryptophan intake at breakfast partially mediated this association.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 1","pages":"62-69"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0