Journal of nutritional science and vitaminology最新文献_第10页

Establishment of Model Mice to Evaluate Low Niacin Nutritional Status. 评价低烟酸营养状况的模型小鼠的建立。

IF 1.6 4区医学

Journal of nutritional science and vitaminology Pub Date : 2023-01-01 DOI: 10.3177/jnsv.69.305

Amane Mizutani, Miu Sato, Hidetsugu Fujigaki, Yasuko Yamamoto, Kuniaki Saito, Sho Hatayama, Tsutomu Fukuwatari

{"title":"Establishment of Model Mice to Evaluate Low Niacin Nutritional Status.","authors":"Amane Mizutani, Miu Sato, Hidetsugu Fujigaki, Yasuko Yamamoto, Kuniaki Saito, Sho Hatayama, Tsutomu Fukuwatari","doi":"10.3177/jnsv.69.305","DOIUrl":"10.3177/jnsv.69.305","url":null,"abstract":"Niacin is involved in many biological reactions relating energy metabolism, redox reactions, DNA repair and longevity, and low NAD levels with aging and feeding high fat diets develop and progress age-related diseases. Although recent findings suggest the requirement of niacin insufficient animal model to further study, appropriate animal models have not been established yet because niacin is biosynthesized from tryptophan via tryptophan-nicotinamide pathway. To establish model mice to evaluate niacin nutritional status, we used kynurenine 3-monooxygenase knock out (KMO-/-) mice which lack NAD biosynthesis pathway from tryptophan. To determine the niacin requirement and assess niacin nutritional markers, 4 wk old KMO-/- mice were fed 2-30 mg/kg nicotinic acid containing diets for 28 d. More than 4 mg/kg but not less than 3 mg/kg nicotinic acid containing diets induced maximum growth, and niacin nutritional markers in the blood, liver and urine increased with increase of dietary nicotinic acid. These results showed that several niacin nutritional markers reflect niacin nutritional status, niacin nutritional status can be controlled by dietary nicotinic acid, and niacin requirement for maximum growth is 4 mg/kg nicotinic acid diets in the KMO-/- mice. This animal model useful to investigate pathophysiology and mechanism of niacin deficiency, clarify the relationships between niacin nutritional status and age-related and lifestyle diseases, and evaluate factors affecting niacin nutritional status.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"69 5","pages":"305-313"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71521770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Methodological Basis for Estimating Human Mercaptalbumin in Serum and Plasma Using a Thiol-Binding Resin. 使用巯基结合树脂估算血清和血浆中人巯基蛋白的方法学基础。

IF 1.6 4区医学

Journal of nutritional science and vitaminology Pub Date : 2023-01-01 DOI: 10.3177/jnsv.69.340

Fuka Tabata, Yasuaki Wada, Satomi Kawakami, Akiko Tamakoshi, Kazuhiro Miyaji

{"title":"A Methodological Basis for Estimating Human Mercaptalbumin in Serum and Plasma Using a Thiol-Binding Resin.","authors":"Fuka Tabata, Yasuaki Wada, Satomi Kawakami, Akiko Tamakoshi, Kazuhiro Miyaji","doi":"10.3177/jnsv.69.340","DOIUrl":"10.3177/jnsv.69.340","url":null,"abstract":"Human serum albumin is categorized into human mercaptalbumin (HMA) and human non-mercaptalbumin (HNA), according to the redox state of the cysteine residue at position 34. The ratio of HMA to total albumin (%HMA) is a novel biomarker of oxidative stress as well as protein nutritional status, but measuring %HMA normally requires an expensive analyzer such as HPLC and LC-MS, and can hardly be conducted in many clinical sites. To address this issue, we aimed to develop a methodological basis for estimating %HMA without these analyzers. An analytical method was investigated consisting of three steps, i.e., 1) removal of HMA from serum or plasma by using a thiol-binding resin (i.e., thereby obtaining a HNA fraction), 2) determination of both total albumin and HNA concentrations by a colorimetric assay or ELISA, and 3) calculation of %HMA. Proof-of-concept experiments, using serum and plasma samples of 4 adult volunteers, showed that the estimated value of %HMA obtained by this analytical method was significantly correlated with the theoretical value of %HMA determined by HPLC. The subsequent validation experiment, using 86 serum samples of pregnant women in the Japanese participants of SMILE Iwamizawa, also confirmed the significant association between the estimated and theoretical values of %HMA. This analytical method can be a basis to determine %HMA without using HPLC or LC-MS, contributing to the universalization of %HMA measurement as a clinical test.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"69 5","pages":"340-346"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71521853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contents of Volume 69. 第 69 卷的内容。

IF 1.6 4区医学

Journal of nutritional science and vitaminology Pub Date : 2023-01-01 DOI: 10.3177/jnsv.69.493

引用次数: 0

Effect of Zinc-Deficient Diet on Two Strains of Mice. 缺锌饮食对两个品系小鼠的影响

IF 1.6 4区医学

Journal of nutritional science and vitaminology Pub Date : 2023-01-01 DOI: 10.3177/jnsv.69.444

Kana Tadokoro, Masanori Ohta, Yukiko Kakuno, Ayaka Iid, Tsuyoshi Nakamura

{"title":"Effect of Zinc-Deficient Diet on Two Strains of Mice.","authors":"Kana Tadokoro, Masanori Ohta, Yukiko Kakuno, Ayaka Iid, Tsuyoshi Nakamura","doi":"10.3177/jnsv.69.444","DOIUrl":"10.3177/jnsv.69.444","url":null,"abstract":"Zinc (Zn) deficiency is one of the most common nutritional deficiencies worldwide. It is associated with reduced nutritional status and has been reported in cases of growth retardation, alopecia, and decreased serum alkaline phosphatase (ALP). It has also been reported to occur during total parenteral nutrition (TPN) administration and is associated with various diseases, such as liver diseases, diabetes, and kidney disease. We used Zn-deficient mice of ICR and C57BL/6J strains to investigate the various effects of Zn deficiency on the body, assuming that a healthy person may also become deficient in Zn either due to an unbalanced diet or malabsorption. The results showed that a Zn-deficient diet suppressed body weight gain and increased the tissue weight of the kidneys and cecum in both strains of mice. Biochemical data showed no decrease in serum ALP activity in either strain. Furthermore, in C57BL/6J mice, a Zn-deficient diet caused alopecia, loss of villi in the small intestine, and eventually affected the intestinal mucosa, which could be a risk factor for poor nutritional status. Although previous reports have shown that serum ALP activity is decreased during Zn deficiency, this is the first study that used 4-wk-old mice of ICR and C57BL/6J strains to show that serum ALP activity, which is a Zn deficiency marker, did not decrease in the two strains of Zn-deficient mice; furthermore, a Zn-deficient diet causes various symptoms.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"69 6","pages":"444-453"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139087288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Essential Amino Acids in the Diet of Children and Adolescents. 儿童和青少年饮食中的必需氨基酸。

IF 1.6 4区医学

Journal of nutritional science and vitaminology Pub Date : 2023-01-01 DOI: 10.3177/jnsv.69.190

Wioletta Waksmanska, Rafal Bobinski, Tomasz Ilczak, Anna Pielesz

{"title":"Essential Amino Acids in the Diet of Children and Adolescents.","authors":"Wioletta Waksmanska, Rafal Bobinski, Tomasz Ilczak, Anna Pielesz","doi":"10.3177/jnsv.69.190","DOIUrl":"https://doi.org/10.3177/jnsv.69.190","url":null,"abstract":"The increasing requirement for energy and nutrients as a child grows older may result in nutritional deficiencies. The research was to assess the intake level of essential amino acids in the daily diet of children and adolescents living in rural areas. The research was conducted using a questionnaire that analysed food products consumed every day. The questionnaires were completed with the help of the researcher over a period of 7 d. Anthropometric measurements were carried out on every research participant. The participants' financial situation was calculated using a 5-degree scale, where 5 meant very good and 1 very bad. Insufficient body mass was recorded in the study group in 11.1% of boys and 14.7% of girls. Excessive body mass occurred more often among the girls (31%) than the boys (27.9%). Among boys aged 7-15 y old, protein provided 12.8% of the calorie requirement, while for the girls the figure was 13.6%. Among pupils aged 16-18 y old, the figures were 14.06% for boys and 14.33% for girls. Analysis of the results showed that irrespective of age or gender, no insufficient intake of amino acids was recorded among the study participants. In the study group of children and adolescents from rural areas, every third study participant suffered from excess body weight. Due to the fact that the intake of essential amino acids exceeded recommended RDA, it is vital that educational programmes are implemented on how to maintain a correctly balanced diet.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"69 3","pages":"190-196"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9742376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Technique of Measurement of Gastrointestinal Luminal Nutrient Sensing and These Absorptions: Ussing Chamber (Short-Circuit Current) Technique. 胃肠营养感测及其吸收的测量技术:利用腔室(短路电流)技术。

IF 1.6 4区医学

Journal of nutritional science and vitaminology Pub Date : 2023-01-01 DOI: 10.3177/jnsv.69.164

Shin-Ichiro Karaki

引用次数: 0

Effects of Combining Docosahexaenoic Acid and Eicosapentaenoic Acid with Sesame Lignan on Vascular Endothelial Function. 二十二碳六烯酸和二十碳五烯酸与芝麻木质素联合应用对血管内皮功能的影响。

IF 1.6 4区医学

Journal of nutritional science and vitaminology Pub Date : 2023-01-01 DOI: 10.3177/jnsv.69.370

Satoshi Morita, Hideyuki Sasaki, Yoshihisa Kaneda, Tomohiro Rogi, Takayuki Izumo, Masaaki Nakai

{"title":"Effects of Combining Docosahexaenoic Acid and Eicosapentaenoic Acid with Sesame Lignan on Vascular Endothelial Function.","authors":"Satoshi Morita, Hideyuki Sasaki, Yoshihisa Kaneda, Tomohiro Rogi, Takayuki Izumo, Masaaki Nakai","doi":"10.3177/jnsv.69.370","DOIUrl":"10.3177/jnsv.69.370","url":null,"abstract":"Vascular endothelial cells produce vasoactive substances, such as nitric oxide (NO), to regulate vascular relaxation and contraction. Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) enhance NO production in endothelial cells, and sesamin, a sesame lignan contained in sesame seeds, also promotes NO production. This study examined DHA, EPA, and sesamin's combined effects since it was expected that combining them would further enhance NO production in endothelial cells. Using a human umbilical vein endothelial cell (HUVEC), the NO amount secreted in the culture supernatant was analyzed. Sesamin metabolite (SC1) was used in the experiments because it is a major metabolite in human blood after sesamin absorption. When cells were treated with DHA or EPA alone, they increased NO production in a concentration-dependent manner, whereas no change in NO production was observed for SC1. NO production increased when DHA and EPA were treated in combination with SC1, although the low DHA and EPA concentrations showed no difference in NO production. In the concentrations in which the combined effect was observed, SC1 activated eNOS via calcium signaling, whereas DHA and EPA activated eNOS via alterations in the membrane lipid environment. The combined effect of the two pathways was considered to have enhanced the eNOS activity. These results suggested that combining DHA, EPA, and sesamin might improve vascular endothelial function.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"69 5","pages":"370-376"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71521768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Intake of Vitamin D during Pregnancy and the Risk of Postpartum Depressive Symptoms: The Japan Environment and Children's Study. 妊娠期膳食维生素D摄入量与产后抑郁症状的风险:日本环境与儿童研究

IF 1.6 4区医学

Journal of nutritional science and vitaminology Pub Date : 2023-01-01 DOI: 10.3177/jnsv.69.14

Kasumi Tsunoda, Kei Hamazaki, Kenta Matsumura, Haruka Kasamatsu, Akiko Tsuchida, Hidekuni Inadera

{"title":"Dietary Intake of Vitamin D during Pregnancy and the Risk of Postpartum Depressive Symptoms: The Japan Environment and Children's Study.","authors":"Kasumi Tsunoda, Kei Hamazaki, Kenta Matsumura, Haruka Kasamatsu, Akiko Tsuchida, Hidekuni Inadera","doi":"10.3177/jnsv.69.14","DOIUrl":"https://doi.org/10.3177/jnsv.69.14","url":null,"abstract":"Many recent clinical and epidemiological studies have demonstrated the effects of vitamin D on health, yet few studies have examined the association of dietary intake of vitamin D during pregnancy with postpartum depressive symptoms. This study examined this association in a large cohort of 74,840 pregnant women who are enrolled in the longitudinal Japan Environment and Children's Study. Dietary vitamin D intake during pregnancy (specifically after learning of the pregnancy to mid-late pregnancy) was determined using the Food Frequency Questionnaire. Postpartum depressive symptoms 1 mo after delivery were assessed using the Edinburgh Postnatal Depression Scale. Logistic regression analysis showed a reduced risk of postpartum depressive symptoms for all except the first quintile of vitamin D intake: second quintile (adjusted odds ratio [95% confidence interval]: 0.88 [0.82-0.94]), third (0.83 [0.78-0.89]), fourth (0.87 [0.81-0.93]), and fifth (0.90 [0.83-0.97]). Post-adjustment trend tests revealed a significant association between dietary vitamin D intake and postpartum depressive symptoms (p for trend=0.004). Our results revealed a higher vitamin D intake during pregnancy was associated with a lower risk of postpartum depressive symptoms 1 mo after delivery, suggesting the potential applicability of vitamin D in reducing postpartum depression.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"69 1","pages":"14-20"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10812258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Vitamin D₃ Promotes Not Motor Coordination but Motor Skill Learning without Influence on Muscle Function. 维生素D3不是促进运动协调，而是促进运动技能学习，而不影响肌肉功能。

IF 1.6 4区医学

Journal of nutritional science and vitaminology Pub Date : 2023-01-01 DOI: 10.3177/jnsv.69.229

Tomohisa Kitamura, Naoko Tsugawa, Honami Ogasawara, Masahito Matsumoto, Keiji Itaka, Masahiko Okubo, Tetsuya Yoda, Tatsuo Suda, Tsuyoshi Sato

{"title":"Vitamin D3 Promotes Not Motor Coordination but Motor Skill Learning without Influence on Muscle Function.","authors":"Tomohisa Kitamura, Naoko Tsugawa, Honami Ogasawara, Masahito Matsumoto, Keiji Itaka, Masahiko Okubo, Tetsuya Yoda, Tatsuo Suda, Tsuyoshi Sato","doi":"10.3177/jnsv.69.229","DOIUrl":"https://doi.org/10.3177/jnsv.69.229","url":null,"abstract":"Although motor coordination or motor skill learning are improved by taking vitamin D in the animal experiment, muscle function have not been estimated. Here we examined the effect of vitamin D3 administration on motor coordination and motor skill learning, muscle strength, and muscle volume in mice fed a vitamin D deficient diet. In mice fed a vitamin D deficient diet, serum calcium and 25(OH)D3 concentrations were measured. We then conducted Rotarod test, beam walking assay, micro-CT analysis, and forelimb grip strength test. Administration of vitamin D3 elongated the retention time in the Rotarod test in a time dependent manner. In contrast, the time to reach a beam goal box in beam walking assay was not changed in mice administered with vitamin D3, compared to the control. Oral administration of vitamin D3 did not affect muscle strength nor muscle volume. Oral administration of vitamin D3 promotes not motor coordination but motor skill learning and does not affect muscle function.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"69 4","pages":"229-236"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10126994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and Application of Monoclonal Antibodies for an Immune Complex Transfer Enzyme Immunoassay of an Egg White Allergen, Lipocalin-Type Prostaglandin D Synthase. 蛋白过敏原脂钙素型前列腺素D合酶的免疫分析

IF 1.6 4区医学

Journal of nutritional science and vitaminology Pub Date : 2023-01-01 DOI: 10.3177/jnsv.69.129

Satoshi Numata, Hao Luo, Makiko Suzuki

{"title":"Preparation and Application of Monoclonal Antibodies for an Immune Complex Transfer Enzyme Immunoassay of an Egg White Allergen, Lipocalin-Type Prostaglandin D Synthase.","authors":"Satoshi Numata, Hao Luo, Makiko Suzuki","doi":"10.3177/jnsv.69.129","DOIUrl":"https://doi.org/10.3177/jnsv.69.129","url":null,"abstract":"We have previously reported that lipocalin-type prostaglandin D synthase (L-PGDS) in egg white reacts with IgE antibodies from children with egg allergies. However, antibodies against chicken L-PGDS are not commercially available, and the amount of L-PGDS in egg white is unclear. In this study, we prepared four monoclonal antibodies against chicken L-PGDS and developed a sandwich enzyme-linked immunosorbent assay (ELISA) and a highly sensitive immune complex transfer enzyme immunoassay (ICT-EIA) to quantify L-PGDS in hen egg whites. The detection sensitivity of ICT-EIA for L-PGDS (0.01 ng/mL) was 2,000-fold higher than that of ELISA, which could not be adapted to determine the amount of L-PGDS in egg white. Thus, ICT-EIA is a better method for quantification of trace allergens and expected to be applied to the quantification of other food allergens. Hen eggs (white-shelled eggs from Julia Lite hens, brown-shelled eggs, and iodine-enriched eggs from Boris Brown hens) were purchased from markets in Kochi City, Japan, and the amounts of L-PGDS in them were determined by ICT-EIA. The amounts of L-PGDS per hen egg white were: brown-shelled eggs, 1,179.3±214.3 μg/egg; iodine-enriched eggs, 607.7±126.1 μg/egg; and white-shelled eggs, 350.0±74.1 μg/egg. These results show that the amount of L-PGDS in hen eggs varies depending on the hen lineage; it could also be affected to some extent by other factors, such as feeds and breeding environment.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"69 2","pages":"129-135"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9392558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0