Journal of nutritional science and vitaminology最新文献_第9页

Effects of Japanese Diet on Post-Exercise Glycogen Recovery in Mice Skeletal Muscle and Liver. 日本饮食对小鼠运动后骨骼肌和肝脏糖原恢复的影响。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.470

Atsuko Koike, Takuya Karasawa, Shin Terada

{"title":"Effects of Japanese Diet on Post-Exercise Glycogen Recovery in Mice Skeletal Muscle and Liver.","authors":"Atsuko Koike, Takuya Karasawa, Shin Terada","doi":"10.3177/jnsv.70.470","DOIUrl":"https://doi.org/10.3177/jnsv.70.470","url":null,"abstract":"The diet consumed by most Japanese people, which contains high amounts of carbohydrate and low levels of fat compared with the Western-style diet (WD), has been considered an effective diet for promoting glycogen recovery after exercise. However, there is no direct evidence to support this general belief, because no studies have examined the effect of whole, actually cooked Japanese-style diet (JD) on post-exercise glycogen replenishment. In this study, we comparatively examined the effects of a cooked typical JD and WD on glycogen accumulation in mouse skeletal muscle and liver after acute exercise. One-week menus (total 21 meals) of the JD and WD were reproduced based on national nutrition surveys in Japan and the U.S. All the meals were cooked, mixed and then fed to mice after acute 60-min running exercise. After the 4-h recovery period, mice given the JD had significantly higher muscle and liver glycogen concentrations than those fed the isoenergetic WD. Furthermore, even after the 24-h recovery period, the JD-fed mice also had significantly higher muscle glycogen concentration than the isoenergetic WD-fed group. Compared with the mice fed a WD, the JD-fed mice showed significantly higher plasma insulin level during the 4-h but not the 24-h recovery period. These results suggest that both short- and long-term feeding of the JD promote post-exercise muscle glycogen recovery compared to the WD, possibly through an insulin-dependent mechanism and non-insulin-dependent mechanism, respectively.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 6","pages":"470-480"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic Oral Intake of Soy Peptide Alleviates Anhedonia in Normally Housed Male C57BL/6J Mice. 长期口服大豆肽可缓解正常饲养的雄性 C57BL/6J 小鼠的失神症状。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.430

Miku Hamasaki, Chihiro Yano, Koki Zeze, Kengo Kuroki, Nana Nishikawa, Hiroaki Kozaki, Shigeki Furuya

引用次数: 0

Individualized Nutritional Management Using Dishcook Improves Nutrition Status Markers in Patients with Intellectual Disability. 使用 Dishcook 进行个性化营养管理可改善智障患者的营养状况指标。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.352

Yuki Niida, Hidenori Onishi, Hirohiko Ohama, Hiromasa Tsubouchi, Akemi Koujimoto, Yasutaka Mizukami, Tomoko Okamoto, Masamichi Ikawa, Masafumi Kubota, Mayu Takebe, Naoko Takaku, Kino Tsuji, Chizu Kawahara, Taisei Inoue, Daiki Hasegawa, Yoshihiro Nakamori, Takeshi Hirobe, Osamu Yamamura

{"title":"Individualized Nutritional Management Using Dishcook Improves Nutrition Status Markers in Patients with Intellectual Disability.","authors":"Yuki Niida, Hidenori Onishi, Hirohiko Ohama, Hiromasa Tsubouchi, Akemi Koujimoto, Yasutaka Mizukami, Tomoko Okamoto, Masamichi Ikawa, Masafumi Kubota, Mayu Takebe, Naoko Takaku, Kino Tsuji, Chizu Kawahara, Taisei Inoue, Daiki Hasegawa, Yoshihiro Nakamori, Takeshi Hirobe, Osamu Yamamura","doi":"10.3177/jnsv.70.352","DOIUrl":"https://doi.org/10.3177/jnsv.70.352","url":null,"abstract":"Dishcook is a new cooking system that allows individual cooking using a dedicated induction heater. This study investigated whether Dishcook use affects the nutritional value of individuals with intellectual disabilities. This study was conducted on users receiving support from a continuous-employment office in Obama City, Fukui Prefecture, in 2022. Of these participants, 18 (seven women and 11 men) who requested the use of the Dishcook were included in the analysis. The study period was from January to August 2023. The mean age was 48.72±16.24 y. A significant increase in the overall phase angles of the limbs was observed. Triglyceride, LDL cholesterol, HbA1c, and serum zinc levels improved in patients who used the Dishcook. The phase angle obtained using Bioelectrical Impedance Analysis also improved, indicating the usefulness of the Dishcook in treating metabolic diseases and the possibility of individualized nutritional management.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 4","pages":"352-358"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Short-Term Zinc-Deficient Diet Maintains Serum Calcium Concentrations through Ca Absorption-Related Gene Expression in Rats. 短期缺锌饮食通过大鼠与钙吸收相关的基因表达维持血清钙浓度

IF 1.6 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.82

Takako Suzuki, Kazuharu Suzuki, Jun Takahashi, Yukio Nakamura

{"title":"A Short-Term Zinc-Deficient Diet Maintains Serum Calcium Concentrations through Ca Absorption-Related Gene Expression in Rats.","authors":"Takako Suzuki, Kazuharu Suzuki, Jun Takahashi, Yukio Nakamura","doi":"10.3177/jnsv.70.82","DOIUrl":"10.3177/jnsv.70.82","url":null,"abstract":"We investigated the effects of short-term dietary zinc deficiency on zinc and calcium metabolism. Four-week-old male Wistar rats were divided into two pair-fed groups for a 1-wk treatment: zinc-deficient group (ZD, 1 ppm); control group (PF, 30 ppm). The mRNA expression of zinc transporters, such as Slc39a (Zip) 4, Zip5, Zip10, and Slc30a (ZnT) 1, in various tissues (liver, kidney, and duodenum) quickly responded to dietary zinc deficiency. Although there was no significant difference in serum calcium concentrations between the PF and ZD groups, serum 1,25-dihydroxycholecalciferol (1,25(OH)2D3) was higher in the ZD group than in the PF group. Moreover, short-term zinc deficiency significantly increased mRNA expression of transient receptor potential (TRP) cation channel subfamily vanilloid (V) member 6, S100 calcium binding protein G (S100g), and ATPase plasma membrane Ca2+ transporting 1 (Atp2b1) in the duodenum. Furthermore, short-term zinc deficiency increased vitamin D receptor (VDR) and cytochrome P450 family 24 subfamily A member 1 (Cyp24a1) mRNA expression in the kidney. These findings suggested that short-term zinc deficiency maintains serum calcium concentrations through Ca absorption-related gene expression in the duodenum, and that short-term zinc deficiency induced the expression of Cyp24a1 in kidney in response to an increase in the serum 1,25(OH)2D3 level.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 1","pages":"82-87"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upregulation Effect of Citrus Species on Brain-Derived Neurotrophic Factor. 柑橘对脑神经营养因子的上调作用

IF 1.6 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.61

Kensuke Nakajima, Ahreum Han, Arisa Kayano, Shigeru Oiso

{"title":"Upregulation Effect of Citrus Species on Brain-Derived Neurotrophic Factor.","authors":"Kensuke Nakajima, Ahreum Han, Arisa Kayano, Shigeru Oiso","doi":"10.3177/jnsv.70.61","DOIUrl":"10.3177/jnsv.70.61","url":null,"abstract":"Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays fundamental roles in neuronal survival and synaptic plasticity. Its upregulation in the brain can effectively prevent and treat central nervous system (CNS) diseases, including depression, Alzheimer's disease (AD), and Parkinson's disease (PD). BDNF is synthesized in various peripheral tissues as well as in the brain and can be transported from peripheral circulation into the brain through the blood-brain barrier. Therefore, foods that upregulate BDNF in peripheral tissues may be beneficial in preventing and treating these CNS diseases. Previously, we revealed that treatment with Chinpi (Citrus unshiu peel) and Citrus natsudaidai increased BDNF levels in the human renal adenocarcinoma cell line ACHN. Here, we evaluated the effects of 21 citrus cultivars on BDNF production in ACHN cells by measuring BDNF levels in the cell culture medium. We found that treatment with peels and pulps of 13 citrus varieties increased BDNF levels in ACHN cells. Treatment with Aurantium, Acrumen, and their hybrids citrus varieties showed a potent BDNF-upregulating effect but not with varieties belonging to Limonellus, Citrophorum, and Cephalocitrus. In addition, treatment with some of those Acrumen and its hybrid citrus species resulted in elevated levels of BDNF transcripts in ACHN cells. These results suggest that peels of many citrus cultivars contain ingredients with a potential BDNF-upregulating ability, which may be novel drug seeds for treating depression, AD, and PD. Furthermore, many citrus cultivars could be used as BDNF-upregulating foods.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 1","pages":"61-71"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fructo-Oligosaccharides Enhance the Expression of Genes Related to Focal Adhesion- and Inflammation-Pathways in Small Intestinal Absorptive Caco-2 Cells. 低聚果糖增强小肠吸收性Caco-2细胞局灶黏附和炎症通路相关基因的表达

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.481

Aya Harasawa, Shiori Ishiyama, Kazuki Mochizuki

{"title":"Fructo-Oligosaccharides Enhance the Expression of Genes Related to Focal Adhesion- and Inflammation-Pathways in Small Intestinal Absorptive Caco-2 Cells.","authors":"Aya Harasawa, Shiori Ishiyama, Kazuki Mochizuki","doi":"10.3177/jnsv.70.481","DOIUrl":"https://doi.org/10.3177/jnsv.70.481","url":null,"abstract":"Recently, we demonstrated, using mRNA microarray analysis, that fructo-oligosaccharides (FOS), which are indigestible carbohydrates, enhanced the expression of several inflammation-related genes, such as CLEC7A, CCL2, ITGA2, and F3, by ≥4-fold in Caco-2 cells, a model of human intestinal absorptive cells, independently of intestinal bacteria (Harasawa A et al., Nutrition, 112140, 2023). However, whether FOS enhances the expression of genes in other pathways, particularly the non-inflammatory pathways, in Caco-2 cells has not been investigated. Here, we explored the pathways affected by FOS, based on identification of differentially expressed genes with ≥2-fold change (linear-fold change) in expression upon FOS treatment. Caco-2 cells were cultured for 24 h in high glucose-Dulbecco's modified Eagle medium supplemented with 10% fetal calf serum containing FOS. The differentially expressed genes in these cells, identified using mRNA microarray analysis, were categorized using the pathway analysis and subsequently upregulated genes in typical pathways were subjected to protein network analysis. RT-qPCR was performed to validate the expression of selected genes. Treatment with 10% FOS enhanced the expression of a set of genes, such as ITGB8, ITGA6, SPP1, CAV1, LAMA3, ARHGAP5, and LAMC2, in the focal adhesion pathway. In addition, this treatment increased the expression of many genes involved in various inflammatory pathways, such as TNF, ITGA5, ITGB3, PTGS2, FGF2, FLNC, EDNRB, VEGFA, and MMP13. Protein network analysis showed that genes in the focal adhesion and endothelin pathways induced by FOS were closely associated with each other. FOS treatment of human intestinal absorptive-like cells enhances a set of genes in the focal adhesion and inflammation pathways.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 6","pages":"481-489"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Disaster Knowledge Level and the First Step of Stockpiling Food for a Disaster. 灾害知识水平与为灾害储备食物的第一步之间的关系。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.422

Moeka Harada, Nobuyo Tsuboyama-Kasaoka, Jun Oka, Rie Kobayashi

{"title":"Association between Disaster Knowledge Level and the First Step of Stockpiling Food for a Disaster.","authors":"Moeka Harada, Nobuyo Tsuboyama-Kasaoka, Jun Oka, Rie Kobayashi","doi":"10.3177/jnsv.70.422","DOIUrl":"https://doi.org/10.3177/jnsv.70.422","url":null,"abstract":"This study clarifies the association between disaster knowledge levels and beginning to stockpile food at home as a disaster preparedness. This survey was conducted between 18-20 December 2019 using a self-administered web-based questionnaire. The participants were recruited from panel members of an online survey company. A total of 1,200 adults living in the five Japanese prefectures with the highest predicted food shortages after the anticipated Nankai Trough earthquake, took part in the study. Multivariable logistic regression analyses revealed a significant positive relationship between disaster knowledge level and beginning food stockpiling (p for trend <0.001). Compared with those who had a low level of disaster knowledge, participants who had a medium level of knowledge were 2.11 times more likely to begin stockpiling food (adjusted odds ratio [OR]: 2.11, 95% confidence intervals [CI]: 1.49-2.97), whereas those with the highest knowledge level were 2.52 times more likely to begin stockpiling food (adjusted OR: 2.52, 95% CI: 1.79-3.56). Beginning food stockpiling can be the first step toward disaster preparedness. It is considered that people with low disaster knowledge levels are more likely to have no beginning food stockpiling and are at high risk for disasters. These findings suggest ways to approach prioritizing people facing high disaster risk.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 5","pages":"422-429"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant Vitamin Intake and LOX-Index in Japanese Municipal Workers. 日本市政工人的抗氧化维生素摄入量和 LOX 指数

IF 1.6 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.36

Mirai Sakanari, Masanori Ohta, Mayumi Nagano, Yoko Umeki, Akiko Nanri

{"title":"Antioxidant Vitamin Intake and LOX-Index in Japanese Municipal Workers.","authors":"Mirai Sakanari, Masanori Ohta, Mayumi Nagano, Yoko Umeki, Akiko Nanri","doi":"10.3177/jnsv.70.36","DOIUrl":"10.3177/jnsv.70.36","url":null,"abstract":"Antioxidant vitamin intake has been reported to be associated with decreased risk of cardiovascular diseases. To date, however, no study has examined the association between antioxidant vitamin intake and LOX-index, a predictive biomarker of cardiovascular disease. We investigated the cross-sectional association between antioxidant vitamin (α-carotene, β-carotene, α-tocopherol, and vitamin C) intake and LOX-index in Japanese municipal workers. Participants were 346 workers (171 men and 175 women aged 19-71 y) who received a health check-up and participated in a nutrition and health survey. Antioxidant vitamin intake was assessed using a validated brief self-administered diet history questionnaire. LOX-index was calculated by multiplying serum concentrations of the soluble form of lectin-like oxidized LDL receptor 1 by those of LOX-1 ligands containing apolipoprotein B. Multiple regression analysis was used to estimate the geometric mean of LOX-index according to tertile of each antioxidant vitamin intake. Overall, α-carotene, β-carotene, α-tocopherol, and vitamin C intake were not associated with LOX-index. However, in stratified analyses by sex, geometric means of LOX-index tended to decrease with antioxidant vitamin intake in women, but not in men. The geometric means of LOX-index for the lowest through highest tertile of α-carotene intake were 771 (604-984), 639 (511-799), and 564 (469-677) (p for trend=0.07). Our results suggest that there is no association between antioxidant vitamin intake and LOX-index in Japanese workers. The suggestive inverse association between antioxidant vitamin intake and LOX-index in women warrants further investigation.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 1","pages":"36-43"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paternal Zinc Deficiency and Its Transgenerational Effects on Zinc Transporters in Drosophila. 果蝇父系锌缺乏及其对锌转运蛋白的跨代影响。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.462

Kamaldeen Olalekan Sanusi, Murtala Bello Abubakar, Kasimu Ghandi Ibrahim, Mustapha Umar Imam

{"title":"Paternal Zinc Deficiency and Its Transgenerational Effects on Zinc Transporters in Drosophila.","authors":"Kamaldeen Olalekan Sanusi, Murtala Bello Abubakar, Kasimu Ghandi Ibrahim, Mustapha Umar Imam","doi":"10.3177/jnsv.70.462","DOIUrl":"https://doi.org/10.3177/jnsv.70.462","url":null,"abstract":"The nutritional status of fathers plays a significant role in influencing the growth, metabolism, and susceptibility to diseases in their offspring. Paternal zinc deficiency can lead to developmental programming effects on the offspring's zinc homeostasis. This study investigated the effects of paternal zinc deficiency on the zinc homeostasis of offspring in a Drosophila melanogaster (fruit fly) model. Male flies were reared on a diet supplemented with a zinc-chelator, N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN), from the egg stage until adulthood, and their offspring were subsequently reared on a normal diet for 7 d. Body zinc status and zinc transporters were assessed afterwards. The results indicated that the prenatal zinc deficiency significantly lowered total body zinc levels (p<0.05) compared to the controls. Additionally, the mRNA levels of zinc transporters, dZip42C.1, dZnT63C, and dZnT35C, were lower in the zinc-deficient male parents (p<0.05) and their male offspring (p<0.05). These findings suggested that paternal zinc deficiency can alter offspring zinc homeostasis, even when the offspring was fed a zinc-sufficient diet. This is an important finding, as zinc is an essential nutrient that is required for a variety of bodily functions. Further research is needed to better understand the mechanisms by which zinc deficiency in the male parent affects the health of the offspring and to develop strategies to prevent this from happening.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 6","pages":"462-469"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of 1-Kestose on the Abundance of Inflammation-Related Gene mRNA in Adipose Tissue and the Gut Microbiota Composition in Rats Fed a High-Fat Diet. 1-Kestose 对高脂饮食大鼠脂肪组织中炎症相关基因 mRNA 丰度和肠道微生物群组成的影响

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.311

Kento Kuramitsu, Yoshihiro Kadota, Ayako Watanabe, Akihito Endo, Yoshiharu Shimomura, Yasuyuki Kitaura

{"title":"The Effects of 1-Kestose on the Abundance of Inflammation-Related Gene mRNA in Adipose Tissue and the Gut Microbiota Composition in Rats Fed a High-Fat Diet.","authors":"Kento Kuramitsu, Yoshihiro Kadota, Ayako Watanabe, Akihito Endo, Yoshiharu Shimomura, Yasuyuki Kitaura","doi":"10.3177/jnsv.70.311","DOIUrl":"https://doi.org/10.3177/jnsv.70.311","url":null,"abstract":"Chronic inflammation in adipose tissue is thought to contribute to insulin resistance, which involves the gut microbiota. Our previous studies have demonstrated that ingestion of 1-kestose can alter the gut microbiota composition, increase cecal butyrate levels, and improve insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Additionally, we found that 1-kestose supplementation ameliorated insulin resistance in obese rat models fed a high-fat diet (HFD), although the effects of 1-kestose on the abundance of inflammation-related gene in adipose tissue and gut microbiota composition in these rats were not explored. This study aimed to investigate the impact of 1-kestose on these parameters in HFD-fed rats, compared to OLETF rats. Male Sprague-Dawley rats were divided into two dietary groups, control or HFD, for 19 wk. Each group was further subdivided to receive either tap water or tap water supplemented with 2% (w/v) 1-kestose throughout the study. We evaluated gene expression in adipose tissue, as well as short-chain fatty acids (SCFAs) levels and microbial composition in the cecum contents. 1-Kestose intake restored the increased relative abundance of tumor necrosis factor (Tnf) mRNA in adipose tissue and the reduced level of butyrate in the cecum contents of HFD-fed rats to those observed in control diet-fed rats. Additionally, 1-kestose consumption changed the composition of the gut microbiota, increasing Butyricicoccus spp., decreasing UGC-005 and Streptococcus spp., in the cecum contents of HFD-fed rats. Our findings suggest that 1-kestose supplementation reduces adipose tissue inflammation and increases butyrate levels in the gut of HFD-fed rats, associated with changes in the gut microbiota composition, distinct from those seen in OLETF rats.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 4","pages":"311-317"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0