Anti-Obesity Effects of a Combination of Whole-Body Vibration Stimulus and Dietary D-Allulose on Rats Fed a High-Fat Diet.

Abstract

Whole-body vibration (WBV) has gained attention as a light-resistance exercise and can increase energy metabolism. The rare sugar D-allulose has anti-obesity effects that are mediated by the suppression of hepatic lipogenesis. In this study, we examined the anti-obesity effects of a combination of WBV and dietary D-allulose in rats fed a high-fat diet. Thirty-two male Wistar rats (3-wk-old) were randomly assigned to four groups: sedentary control (C), WBV (V), D-allulose (A), and WBV+D-allulose (VA). Rats in Groups A and VA were fed a 5% D-allulose diet, and rats in Groups V and VA were subjected to WBV using a vibrating platform during the 8-wk experimental period. Total abdominal adipose tissue was significantly lower in Groups V, A, and VA than that in Group C, whereas no differences were observed between Groups V, A, and VA. Dietary D-allulose significantly decreased the weights and percentages of carcass and total body fats, whereas the WBV stimulus significant reduced only the total body fat mass. We observed that both long-term WBV stimulation and dietary D-allulose intake inhibited body fat accumulation in rats fed a high-fat diet, which led to obesity; however, no synergistic effect of this combination could be confirmed.