Li Zhang, ChenChen Li, Yan Gao, ZiWen Zhang, Lin Li, Jing Hu, Ling Tian
{"title":"Clinical Correlation of the Severity of Vascular Calcification with Calcium and Phosphorus Metabolism and Microinflammation in Malnourished Uremic Patients.","authors":"Li Zhang, ChenChen Li, Yan Gao, ZiWen Zhang, Lin Li, Jing Hu, Ling Tian","doi":"10.3177/jnsv.71.148","DOIUrl":"https://doi.org/10.3177/jnsv.71.148","url":null,"abstract":"<p><p>The research assessed calcium (Ca) and phosphorus (P) metabolism and microinflammation in malnourished uremic patients, focusing on the severity of vascular calcification, and examined the relationship between Ca and P metabolism indicators and microinflammation and the severity of vascular calcification. Seventy-eight patients undergoing hemodialysis treatment for ≥6 mo were collected. General information and anthropometric and blood biochemical indices were recorded, including gender, age, body mass index, mid-arm muscle circumference, albumin, intact parathyroid hormone, and Ca and P product (Ca×P). The severity of vascular calcification was graded. The correlation between the severity of vascular calcification in patients and each of the clinical indicators was analyzed. The diagnostic value of Ca and P metabolism and microinflammatory factors for vascular calcification in malnourished uremic patients was assessed. All enrolled patients were divided into a non-vascular calcification group (n=42) and a vascular calcification group (n=36) according to coronary artery calcification (CAC) scoring, and the probability of vascular calcification was 46%. The dialysis duration, Ca×P, P, hypersensitive C-reactive protein (hs-CRP), and interleukin 6 (IL-6) levels were significantly higher in the vascular calcification group than in the non-vascular calcification group. hs-CRP, IL-6, Ca×P, and P had predictive potency for vascular calcification in patients. CAC scores were correlated positively with hs-CRP, IL-6, Ca×P, and P. Malnourished uremic patients have a higher incidence of vascular calcification. hs-CRP, IL-6, Ca×P, and P are all independent risk factors for vascular calcification in uremic patients, and are positively correlated with the severity of vascular calcification.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"148-154"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of Dietary Menthol on Autonomic Thermoregulation in a Cold Environment.","authors":"Noriyuki Mori, Masumi Takano, Aya Nakashima, Eriko Inoue, Miki Yanai, Nanako Kondo, Asaka Maikuma","doi":"10.3177/jnsv.71.173","DOIUrl":"https://doi.org/10.3177/jnsv.71.173","url":null,"abstract":"<p><p>Human body temperature homeostasis is regulated by both behavioral and autonomic thermoregulation. The transient receptor potential melastatin 8 (TRPM8) channel, a cold receptor, plays a critical role in cold perception and thermoregulation. Menthol, which activates TRPM8, has been shown to promote the \"browning\" of white adipocytes, enhancing thermogenesis. However, its effect on autonomic thermoregulation has remained unclear. To address this, the present study examines the influence of dietary menthol intake on autonomic thermoregulation in mice, with a focus on body temperature regulation under cold conditions. In this experiment, mice were fed diets containing 0.25% and 0.5% menthol for either 2 or 4 wk. The results indicated that the 0.5% menthol diet significantly reduced food intake, body weight, and visceral fat. In contrast, the 0.25% menthol diet showed no significant impact on these factors. Notably, mice treated with the 0.25% menthol diet for 4 wk suppressed the decrease in rectal and interscapular brown adipose tissue (IBAT) temperatures in a cold environment under anesthesia. Additionally, TRPM8 gene expression in IBAT was upregulated after 4 wk of 0.25% menthol diet consumption. These findings suggest that dietary menthol, especially at low concentrations, improves autonomic thermoregulation by activating TRPM8 without significantly affecting food intake or body weight.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"173-179"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Calcium, Vitamin D, and Dairy Intake and Premenstrual Syndrome: A Cross-Sectional Study.","authors":"Akiko Nanri, Mirai Sakanari, Haruka Mantani, Anri Hirabayashi, Momoka Furuse, Natsuki Yokote, Michi Nakamura, Takashi Takeda, Masanori Ohta","doi":"10.3177/jnsv.71.155","DOIUrl":"https://doi.org/10.3177/jnsv.71.155","url":null,"abstract":"<p><p>Calcium and vitamin D have been suggested to be associated with the amelioration of symptoms of premenstrual syndrome (PMS). However, evidence for an association between the dietary intake of these nutrients and PMS is limited and inconsistent. We examined the cross-sectional association of calcium and vitamin D intake with PMS. Participants were 390 women aged 22-49 y who responded to a mail survey in 2022-2023. Dietary intake was assessed using a validated self-administered diet history questionnaire. PMS were assessed using the Premenstrual Symptoms Questionnaire. Logistic regression analysis was used to estimate odds ratios of PMS according to tertiles of calcium and vitamin D intake with adjustment for potential confounding variables. The prevalence of moderate to severe PMS was 10% (39 women). Neither calcium nor vitamin D intake was significantly associated with PMS. However, calcium intake was associated with a decreased prevalence of PMS, albeit without statistical significance, with multivariable-adjusted odds ratios (95% CI) for PMS in the lowest through highest tertiles of calcium intake of 1.00 (reference), 0.47 (0.18-1.25), and 0.27 (0.07-1.08), respectively (p for trend=0.06). The odds ratio of PMS was low in the highest tertile of vitamin D intake compared with the lowest, but without statistical significance (odds ratio 0.56, 95% CI 0.19-1.66). Our findings suggest that calcium and vitamin D intake was not appreciably associated with PMS. The suggestive inverse association between calcium intake and PMS requires further investigation.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"155-162"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The J-Curve Relationship between Free Carnitine Levels and Cardiovascular Events in Patients with Heart Failure.","authors":"Shingo Watanabe, Junichi Onuma, Michio Usui","doi":"10.3177/jnsv.71.140","DOIUrl":"https://doi.org/10.3177/jnsv.71.140","url":null,"abstract":"<p><p>Hypocarnitinemia is thought to exacerbate heart failure by impairing mitochondrial function and increasing oxidative stress. While some studies suggest that elevated acylcarnitine levels are linked to cardiovascular events, limited data are available on the relationship between free carnitine levels and clinical outcomes in heart failure patients. This study aimed to investigate the association between free carnitine levels and clinical outcomes in patients hospitalized for heart failure. This retrospective study included 271 consecutive patients admitted to our hospital for their first episode of acute heart failure. Patients were divided into four quartiles based on free carnitine levels (quartile 1: <37.0 μmol/L, n=69; quartile 2: 37.0-49.7 μmol/L, n=68; quartile 3: 49.7-58.9 μmol/L, n=67; quartile 4: ≥58.9 μmol/L, n=67). The primary endpoints were 1-y cardiac mortality, rehospitalization due to heart failure, and its composite endpoint. The incidence of cardiovascular events was compared among the quartiles. Creatinine levels were significantly higher in quartile 4 than in other groups. There were no significant differences in age or BNP among the four groups. Additionally, the 1-y mortality rate was significantly higher in both quartile 1 and quartile 4, while the rehospitalization rate for heart failure within 1 y post-discharge was significantly higher in quartile 4. In summary, the relationship between free carnitine levels and mortality in heart failure patients showed a J-curve pattern, with both low and high levels associated with worse outcomes. Thus, extreme free carnitine levels may serve as potential risk factors for adverse clinical outcomes in this population.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"140-147"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of the Effects of Short-Term Pterostilbene Intake on Healthy Participants: A Pilot Study.","authors":"Kurataka Otsuka, Daisuke Kuriki, Keiko Kamachi, Akira Tanaka, Ryosuke Matsuoka","doi":"10.3177/jnsv.71.70","DOIUrl":"10.3177/jnsv.71.70","url":null,"abstract":"<p><p>Pterostilbene, a polyphenolic compound and an analog of resveratrol, exerts various biological activities and has higher bioavailability and metabolic stability than resveratrol. However, the effectiveness of pterostilbene intake in humans, particularly its effect on blood microRNA (miRNA) expression levels, has not been evaluated. Accordingly, this pilot study aimed to investigate the effects of pterostilbene on blood biochemistry and blood miRNA expression levels and the safety of continuous intake at doses of 10 or 100 mg/d over 12 wk. A double-blind, placebo-controlled parallel-arm comparison trial was conducted with 30 healthy men. In the analysis of blood miRNA expression levels, miR-34a and miR-193b showed very high increases at week 4 and after week 4 of intake, respectively, suggesting that the responders might be present among participants in the pterostilbene intake group. No adverse events were reported during the trial in any participant, and no abnormalities were observed upon examination by the responsible physician. Thus, pterostilbene intake would regulate blood miRNA expression levels, and the results can be utilized in human studies investigating miRNA expression levels with functional food ingredients.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"70-80"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synergistic Effects of Short- and Long-Chain Fructans: A Novel Strategy for Mitigating Ovalbumin Allergy via Microbiome-Driven Acetate Production.","authors":"Hideaki Takahashi, Tadashi Fujii, Chikako Yamada, Kotoyo Fujiki, Nobuhiro Kondo, Kento Kuramitsu, Kohei Funasaka, Eizaburo Ohno, Yoshiki Hirooka, Takumi Tochio","doi":"10.3177/jnsv.71.238","DOIUrl":"https://doi.org/10.3177/jnsv.71.238","url":null,"abstract":"<p><p>The gut microbiota has been implicated in the modulation of food allergies. Building on previous studies on the preventive effects of combining short-chain fructan 1-kestose (Kes) and long-chain fructan inulin (Inu) in food allergies, we investigated their therapeutic effects in an ovalbumin (OVA)-induced food allergy mouse model. Following OVA sensitization, the mice received 5% Kes and Inu, either individually or a combined 2.5% dose of each, for 4 wk. We assessed allergy-related markers, such as OVA-specific serum IgE (OVA-sIgE) levels, in the blood and monitored changes in the gut microbiome. The intake of fructans ameliorated allergic symptoms and stabilized rectal temperatures, with a significant reduction in OVA-sIgE levels only in the combined Kes and Inu group (Kes+Inu), p<0.05. Gut microbiota diversity analysis revealed significant differences in beta diversity between the groups not receiving fructans and those receiving Kes, Inu, or Kes+Inu (p<0.01 each). Specifically, in the Kes+Inu group, the abundance of the genus UBA7173 belonging to the family Muribaculaceae significantly increased. Additionally, acetate levels were significantly elevated only in the Kes+Inu group and correlated positively with the presence of the genus UBA7173. These findings indicated that the combined intake of Kes and Inu improves allergic outcomes, positively affects the gut microbiome, and enhances the production of acetate.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 3","pages":"238-247"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of Ascorbic Acid Levels and Hepatic L-Gulonolactone Oxidase Activity in KK-Ay Mice and Streptozotocin-Diabetic Mice under Hyperglycemic Conditions.","authors":"Keizo Umegaki, Kaori Yokotani, Kanna Ieiri, Hiroaki Kawasaki","doi":"10.3177/jnsv.71.101","DOIUrl":"https://doi.org/10.3177/jnsv.71.101","url":null,"abstract":"<p><p>Blood ascorbic acid (AsA) concentrations are lower in diabetic patients than in the general population, a phenomenon that is also observed in streptozotocin (STZ)-diabetic models of type 1 diabetes. However, the occurrence of diabetes in KK-Ay mice, a model for type 2 diabetes, the most common form of diabetes, remains unclear. Although this mouse can synthesize AsA, understanding its level changes during diabetes progression could help in analyzing AsA's effects on type 2 diabetes. Therefore, the present study investigated the relationship between hyperglycemia and AsA concentrations in the blood and organs of KK-Ay mice, and discussed the findings in relation to those observed in STZ-diabetic mice. Male KK-Ay mice were examined at different stages of diabetes (pre-diabetic, early onset, and hyperglycemic maintenance). STZ-diabetic mice were generated by administering STZ to ICR mice. AsA concentrations were measured in plasma, blood mononuclear cells, and tissues, along with hepatic L-gulonolactone oxidase (GLO) activity and mRNA expression levels. Unexpectedly, AsA concentrations in KK-Ay mice increased under hyperglycemic conditions, while they decreased in STZ-diabetic mice. A consistent relationship was not observed between organ AsA concentrations and hyperglycemia. GLO activity and mRNA expression levels increased in KK-Ay mice, but decreased in STZ-diabetic mice, suggesting an innate defense mechanism against hyperglycemia in KK-Ay mice. These results indicate that different diabetes models exhibit distinct changes in AsA concentrations and hepatic GLO activity under hyperglycemic conditions, highlighting the importance of considering endogenous AsA when evaluating the antioxidant properties of dietary components in KK-Ay mice.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"101-109"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Powdered Morus australis Leaves on Arterial Stiffness Response after Sucrose Ingestion in Healthy Young Men: A Pilot Study.","authors":"Daisuke Kume, Masato Nishiwaki, Masaaki Ito","doi":"10.3177/jnsv.71.63","DOIUrl":"10.3177/jnsv.71.63","url":null,"abstract":"<p><p>Acute arterial stiffening occurs during postprandial hyperglycemia. Such vascular responses are suggested to be averted by suppressing the postprandial glycemic response. We previously developed an α-glucosidase-inhibiting tea powder from the leaves of Morus australis (M. australis), a mulberry species distributed in the Ryukyu Islands, and demonstrated that this powder has an inhibitory effect on blood glucose elevation after sucrose ingestion. This study aimed to investigate the effect of powdered M. australis leaf intake on the arterial stiffness response after sucrose ingestion. In a randomized crossover design, 12 healthy young men completed two trials: with (mulberry [M] trial) and without (control [C] trial) intake of powdered M. australis leaves before ingestion of 75 g of sucrose. Blood glucose levels and brachial-ankle pulse wave velocity (baPWV), an index of systemic arterial stiffness, were measured at baseline and 30, 60, and 120 min after ingestion. Both trials caused a significant increase in blood glucose levels at 30 and 60 min after ingestion, with significantly lower values at 30 min after ingestion in the M trial than in the C trial. baPWV significantly increased at 60 min after ingestion in the C trial, but not in the M trial. These findings demonstrate that prior ingestion of powdered M. australis leaves can prevent the transient arterial stiffening after sucrose ingestion in healthy young men.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"63-69"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effects of Nutrition Education for Breakfast Intake on Morning Gastric Motility in High School Students Living in Dormitories.","authors":"Shiori Wakisaka, Yukina Yumen, Yumi Takayama, Kayo Yoshitani, Miyoko Okuzono, Akari Iwami, Narumi Nagai","doi":"10.3177/jnsv.71.277","DOIUrl":"https://doi.org/10.3177/jnsv.71.277","url":null,"abstract":"<p><p>Skipping breakfast is observed in approximately 30% of youth. Since gastric motility is involved in morning appetite, we conducted a 2-wk nutrition education program for high school dormitory students to encourage breakfast consumption and examined whether gastric myoelectrical activity before breakfast was improved. Gastric motility was assessed by measuring the dominant frequency (DF), derived from power spectrum analysis of normal waves occurring approximately three times per minute, and the percentage (%) normal power. Participants were divided into a normal-gastric motility group (Normal-GM, DF ≥ 2.5 cpm, % normal power ≥50%, n=10) and a low-gastric motility group (Low-GM, DF<2.5 cpm, % normal power <50%, n=7) based on the morning gastric motility index. Nutrition education (i.e. the intervention) was provided to all participants and the same measurements were taken 2 wk later. The results showed an improvement in DF in the Low-GM group (1.99±0.09 cpm to 2.90±0.22 cpm, p=0.008) after the intervention. In addition, % normal power increased significantly only in the Low-GM group (42.9±2.6% to 54.2±2.9%, p=0.047). These results suggest that regular breakfast consumption may help normalize lower morning gastric motility in high school students.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 3","pages":"277-282"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between the Frequency of the Combined Staple, Main, and Side Dishes Examined Using a Validated Questionnaire and the Intake of Nutrients and Food Groups among Young and Middle-Aged Japanese Adults: Results from the DOSANCO Health Study: A Cross-Sectional Study.","authors":"Akinori Yaegashi, Emiko Okada, Takashi Kimura, Koshi Nakamura, Shigekazu Ukawa, Takafumi Nakagawa, Akihiro Imae, Mami Matsushita, Yukiko Minegishi, Izumi Momose, Mari Shimizu, Junko Suzuki, Chizuru Kubo, Atsuko Yamaguchi, Manabu Musashi, Iwao Ohkubo, Akiko Tamakoshi","doi":"10.3177/jnsv.71.201","DOIUrl":"https://doi.org/10.3177/jnsv.71.201","url":null,"abstract":"<p><p>To clarify the association between the intake frequency of a meal combination of staple, main, and side dishes (SMS meal), determined using a validated questionnaire, and the intake of various nutrients and food groups among Japanese adults. In this cross-sectional study, we analyzed data from 936 persons aged 18-64 y who participated in the Dynamics of Lifestyle and Neighborhood Community on Health Study. The intake frequency of SMS meals was assessed using our validated questionnaire and validated. The intake of nutrients and food groups was examined using validated food-frequency questionnaires. To examine the association of the intake frequency of SMS meals with the intake of specific nutrients and food groups, linear regression analysis was conducted with adjustment for age, body mass index, education history, living status (alone or not), smoking status, and alcohol drinking. The intake frequency of SMS meals was significantly positively associated with the intake of 24/32 nutrients in men, 8/32 nutrients in women, 6/16 food groups in men, and 1/16 food groups in women, and significantly negatively associated with 2/16 food groups in men. A higher intake frequency of SMS meals was not significantly associated with a higher intake of salt or saturated fats. Our results suggest that a higher intake frequency of SMS meals, examined using a validated questionnaire, may be associated with a higher intake of certain nutrients and food groups among young and middle-aged adults without a higher intake of salt and saturated fats.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 3","pages":"201-210"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}