Journal of nutritional science and vitaminology最新文献

Clinical Correlation of the Severity of Vascular Calcification with Calcium and Phosphorus Metabolism and Microinflammation in Malnourished Uremic Patients. 营养不良尿毒症患者血管钙化程度与钙磷代谢及微炎症的临床相关性

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.148

Li Zhang, ChenChen Li, Yan Gao, ZiWen Zhang, Lin Li, Jing Hu, Ling Tian

{"title":"Clinical Correlation of the Severity of Vascular Calcification with Calcium and Phosphorus Metabolism and Microinflammation in Malnourished Uremic Patients.","authors":"Li Zhang, ChenChen Li, Yan Gao, ZiWen Zhang, Lin Li, Jing Hu, Ling Tian","doi":"10.3177/jnsv.71.148","DOIUrl":"https://doi.org/10.3177/jnsv.71.148","url":null,"abstract":"The research assessed calcium (Ca) and phosphorus (P) metabolism and microinflammation in malnourished uremic patients, focusing on the severity of vascular calcification, and examined the relationship between Ca and P metabolism indicators and microinflammation and the severity of vascular calcification. Seventy-eight patients undergoing hemodialysis treatment for ≥6 mo were collected. General information and anthropometric and blood biochemical indices were recorded, including gender, age, body mass index, mid-arm muscle circumference, albumin, intact parathyroid hormone, and Ca and P product (Ca×P). The severity of vascular calcification was graded. The correlation between the severity of vascular calcification in patients and each of the clinical indicators was analyzed. The diagnostic value of Ca and P metabolism and microinflammatory factors for vascular calcification in malnourished uremic patients was assessed. All enrolled patients were divided into a non-vascular calcification group (n=42) and a vascular calcification group (n=36) according to coronary artery calcification (CAC) scoring, and the probability of vascular calcification was 46%. The dialysis duration, Ca×P, P, hypersensitive C-reactive protein (hs-CRP), and interleukin 6 (IL-6) levels were significantly higher in the vascular calcification group than in the non-vascular calcification group. hs-CRP, IL-6, Ca×P, and P had predictive potency for vascular calcification in patients. CAC scores were correlated positively with hs-CRP, IL-6, Ca×P, and P. Malnourished uremic patients have a higher incidence of vascular calcification. hs-CRP, IL-6, Ca×P, and P are all independent risk factors for vascular calcification in uremic patients, and are positively correlated with the severity of vascular calcification.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"148-154"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Dietary Menthol on Autonomic Thermoregulation in a Cold Environment. 饲粮薄荷醇对低温环境下自主体温调节的影响。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.173

Noriyuki Mori, Masumi Takano, Aya Nakashima, Eriko Inoue, Miki Yanai, Nanako Kondo, Asaka Maikuma

{"title":"Effects of Dietary Menthol on Autonomic Thermoregulation in a Cold Environment.","authors":"Noriyuki Mori, Masumi Takano, Aya Nakashima, Eriko Inoue, Miki Yanai, Nanako Kondo, Asaka Maikuma","doi":"10.3177/jnsv.71.173","DOIUrl":"https://doi.org/10.3177/jnsv.71.173","url":null,"abstract":"Human body temperature homeostasis is regulated by both behavioral and autonomic thermoregulation. The transient receptor potential melastatin 8 (TRPM8) channel, a cold receptor, plays a critical role in cold perception and thermoregulation. Menthol, which activates TRPM8, has been shown to promote the \"browning\" of white adipocytes, enhancing thermogenesis. However, its effect on autonomic thermoregulation has remained unclear. To address this, the present study examines the influence of dietary menthol intake on autonomic thermoregulation in mice, with a focus on body temperature regulation under cold conditions. In this experiment, mice were fed diets containing 0.25% and 0.5% menthol for either 2 or 4 wk. The results indicated that the 0.5% menthol diet significantly reduced food intake, body weight, and visceral fat. In contrast, the 0.25% menthol diet showed no significant impact on these factors. Notably, mice treated with the 0.25% menthol diet for 4 wk suppressed the decrease in rectal and interscapular brown adipose tissue (IBAT) temperatures in a cold environment under anesthesia. Additionally, TRPM8 gene expression in IBAT was upregulated after 4 wk of 0.25% menthol diet consumption. These findings suggest that dietary menthol, especially at low concentrations, improves autonomic thermoregulation by activating TRPM8 without significantly affecting food intake or body weight.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"173-179"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium, Vitamin D, and Dairy Intake and Premenstrual Syndrome: A Cross-Sectional Study. 钙、维生素D和乳制品摄入与经前综合症：一项横断面研究。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.155

Akiko Nanri, Mirai Sakanari, Haruka Mantani, Anri Hirabayashi, Momoka Furuse, Natsuki Yokote, Michi Nakamura, Takashi Takeda, Masanori Ohta

{"title":"Calcium, Vitamin D, and Dairy Intake and Premenstrual Syndrome: A Cross-Sectional Study.","authors":"Akiko Nanri, Mirai Sakanari, Haruka Mantani, Anri Hirabayashi, Momoka Furuse, Natsuki Yokote, Michi Nakamura, Takashi Takeda, Masanori Ohta","doi":"10.3177/jnsv.71.155","DOIUrl":"https://doi.org/10.3177/jnsv.71.155","url":null,"abstract":"Calcium and vitamin D have been suggested to be associated with the amelioration of symptoms of premenstrual syndrome (PMS). However, evidence for an association between the dietary intake of these nutrients and PMS is limited and inconsistent. We examined the cross-sectional association of calcium and vitamin D intake with PMS. Participants were 390 women aged 22-49 y who responded to a mail survey in 2022-2023. Dietary intake was assessed using a validated self-administered diet history questionnaire. PMS were assessed using the Premenstrual Symptoms Questionnaire. Logistic regression analysis was used to estimate odds ratios of PMS according to tertiles of calcium and vitamin D intake with adjustment for potential confounding variables. The prevalence of moderate to severe PMS was 10% (39 women). Neither calcium nor vitamin D intake was significantly associated with PMS. However, calcium intake was associated with a decreased prevalence of PMS, albeit without statistical significance, with multivariable-adjusted odds ratios (95% CI) for PMS in the lowest through highest tertiles of calcium intake of 1.00 (reference), 0.47 (0.18-1.25), and 0.27 (0.07-1.08), respectively (p for trend=0.06). The odds ratio of PMS was low in the highest tertile of vitamin D intake compared with the lowest, but without statistical significance (odds ratio 0.56, 95% CI 0.19-1.66). Our findings suggest that calcium and vitamin D intake was not appreciably associated with PMS. The suggestive inverse association between calcium intake and PMS requires further investigation.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"155-162"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The J-Curve Relationship between Free Carnitine Levels and Cardiovascular Events in Patients with Heart Failure. 心力衰竭患者游离肉碱水平与心血管事件的j曲线关系

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.140

Shingo Watanabe, Junichi Onuma, Michio Usui

{"title":"The J-Curve Relationship between Free Carnitine Levels and Cardiovascular Events in Patients with Heart Failure.","authors":"Shingo Watanabe, Junichi Onuma, Michio Usui","doi":"10.3177/jnsv.71.140","DOIUrl":"https://doi.org/10.3177/jnsv.71.140","url":null,"abstract":"Hypocarnitinemia is thought to exacerbate heart failure by impairing mitochondrial function and increasing oxidative stress. While some studies suggest that elevated acylcarnitine levels are linked to cardiovascular events, limited data are available on the relationship between free carnitine levels and clinical outcomes in heart failure patients. This study aimed to investigate the association between free carnitine levels and clinical outcomes in patients hospitalized for heart failure. This retrospective study included 271 consecutive patients admitted to our hospital for their first episode of acute heart failure. Patients were divided into four quartiles based on free carnitine levels (quartile 1: <37.0 μmol/L, n=69; quartile 2: 37.0-49.7 μmol/L, n=68; quartile 3: 49.7-58.9 μmol/L, n=67; quartile 4: ≥58.9 μmol/L, n=67). The primary endpoints were 1-y cardiac mortality, rehospitalization due to heart failure, and its composite endpoint. The incidence of cardiovascular events was compared among the quartiles. Creatinine levels were significantly higher in quartile 4 than in other groups. There were no significant differences in age or BNP among the four groups. Additionally, the 1-y mortality rate was significantly higher in both quartile 1 and quartile 4, while the rehospitalization rate for heart failure within 1 y post-discharge was significantly higher in quartile 4. In summary, the relationship between free carnitine levels and mortality in heart failure patients showed a J-curve pattern, with both low and high levels associated with worse outcomes. Thus, extreme free carnitine levels may serve as potential risk factors for adverse clinical outcomes in this population.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"140-147"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the Effects of Short-Term Pterostilbene Intake on Healthy Participants: A Pilot Study. 短期摄入紫檀芪对健康参与者的影响分析：一项初步研究。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.70

Kurataka Otsuka, Daisuke Kuriki, Keiko Kamachi, Akira Tanaka, Ryosuke Matsuoka

{"title":"Analysis of the Effects of Short-Term Pterostilbene Intake on Healthy Participants: A Pilot Study.","authors":"Kurataka Otsuka, Daisuke Kuriki, Keiko Kamachi, Akira Tanaka, Ryosuke Matsuoka","doi":"10.3177/jnsv.71.70","DOIUrl":"10.3177/jnsv.71.70","url":null,"abstract":"Pterostilbene, a polyphenolic compound and an analog of resveratrol, exerts various biological activities and has higher bioavailability and metabolic stability than resveratrol. However, the effectiveness of pterostilbene intake in humans, particularly its effect on blood microRNA (miRNA) expression levels, has not been evaluated. Accordingly, this pilot study aimed to investigate the effects of pterostilbene on blood biochemistry and blood miRNA expression levels and the safety of continuous intake at doses of 10 or 100 mg/d over 12 wk. A double-blind, placebo-controlled parallel-arm comparison trial was conducted with 30 healthy men. In the analysis of blood miRNA expression levels, miR-34a and miR-193b showed very high increases at week 4 and after week 4 of intake, respectively, suggesting that the responders might be present among participants in the pterostilbene intake group. No adverse events were reported during the trial in any participant, and no abnormalities were observed upon examination by the responsible physician. Thus, pterostilbene intake would regulate blood miRNA expression levels, and the results can be utilized in human studies investigating miRNA expression levels with functional food ingredients.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"70-80"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Powdered Morus australis Leaves on Arterial Stiffness Response after Sucrose Ingestion in Healthy Young Men: A Pilot Study. 桑叶粉对健康青年摄入蔗糖后动脉僵硬反应的影响：一项初步研究。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.63

Daisuke Kume, Masato Nishiwaki, Masaaki Ito

{"title":"Effect of Powdered Morus australis Leaves on Arterial Stiffness Response after Sucrose Ingestion in Healthy Young Men: A Pilot Study.","authors":"Daisuke Kume, Masato Nishiwaki, Masaaki Ito","doi":"10.3177/jnsv.71.63","DOIUrl":"10.3177/jnsv.71.63","url":null,"abstract":"Acute arterial stiffening occurs during postprandial hyperglycemia. Such vascular responses are suggested to be averted by suppressing the postprandial glycemic response. We previously developed an α-glucosidase-inhibiting tea powder from the leaves of Morus australis (M. australis), a mulberry species distributed in the Ryukyu Islands, and demonstrated that this powder has an inhibitory effect on blood glucose elevation after sucrose ingestion. This study aimed to investigate the effect of powdered M. australis leaf intake on the arterial stiffness response after sucrose ingestion. In a randomized crossover design, 12 healthy young men completed two trials: with (mulberry [M] trial) and without (control [C] trial) intake of powdered M. australis leaves before ingestion of 75 g of sucrose. Blood glucose levels and brachial-ankle pulse wave velocity (baPWV), an index of systemic arterial stiffness, were measured at baseline and 30, 60, and 120 min after ingestion. Both trials caused a significant increase in blood glucose levels at 30 and 60 min after ingestion, with significantly lower values at 30 min after ingestion in the M trial than in the C trial. baPWV significantly increased at 60 min after ingestion in the C trial, but not in the M trial. These findings demonstrate that prior ingestion of powdered M. australis leaves can prevent the transient arterial stiffening after sucrose ingestion in healthy young men.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"63-69"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Ascorbic Acid Levels and Hepatic L-Gulonolactone Oxidase Activity in KK-Ay Mice and Streptozotocin-Diabetic Mice under Hyperglycemic Conditions. 高血糖条件下KK-Ay小鼠和链脲霉素糖尿病小鼠抗坏血酸水平和肝脏l -古罗内酯氧化酶活性的比较

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.101

Keizo Umegaki, Kaori Yokotani, Kanna Ieiri, Hiroaki Kawasaki

{"title":"Comparison of Ascorbic Acid Levels and Hepatic L-Gulonolactone Oxidase Activity in KK-Ay Mice and Streptozotocin-Diabetic Mice under Hyperglycemic Conditions.","authors":"Keizo Umegaki, Kaori Yokotani, Kanna Ieiri, Hiroaki Kawasaki","doi":"10.3177/jnsv.71.101","DOIUrl":"https://doi.org/10.3177/jnsv.71.101","url":null,"abstract":"Blood ascorbic acid (AsA) concentrations are lower in diabetic patients than in the general population, a phenomenon that is also observed in streptozotocin (STZ)-diabetic models of type 1 diabetes. However, the occurrence of diabetes in KK-Ay mice, a model for type 2 diabetes, the most common form of diabetes, remains unclear. Although this mouse can synthesize AsA, understanding its level changes during diabetes progression could help in analyzing AsA's effects on type 2 diabetes. Therefore, the present study investigated the relationship between hyperglycemia and AsA concentrations in the blood and organs of KK-Ay mice, and discussed the findings in relation to those observed in STZ-diabetic mice. Male KK-Ay mice were examined at different stages of diabetes (pre-diabetic, early onset, and hyperglycemic maintenance). STZ-diabetic mice were generated by administering STZ to ICR mice. AsA concentrations were measured in plasma, blood mononuclear cells, and tissues, along with hepatic L-gulonolactone oxidase (GLO) activity and mRNA expression levels. Unexpectedly, AsA concentrations in KK-Ay mice increased under hyperglycemic conditions, while they decreased in STZ-diabetic mice. A consistent relationship was not observed between organ AsA concentrations and hyperglycemia. GLO activity and mRNA expression levels increased in KK-Ay mice, but decreased in STZ-diabetic mice, suggesting an innate defense mechanism against hyperglycemia in KK-Ay mice. These results indicate that different diabetes models exhibit distinct changes in AsA concentrations and hepatic GLO activity under hyperglycemic conditions, highlighting the importance of considering endogenous AsA when evaluating the antioxidant properties of dietary components in KK-Ay mice.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"101-109"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Phylloquinone Content in 42 Species Algae Inhabiting the Japanese Coast and Relationship between Phylloquinone and Chlorophyll Contents. 日本海岸42种藻类叶绿醌含量评价及与叶绿素含量的关系

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.118

Rina Tanaka, Toshiyuki Shibata, Kosuke Yamamoto, Ryusuke Tanaka

{"title":"Evaluation of Phylloquinone Content in 42 Species Algae Inhabiting the Japanese Coast and Relationship between Phylloquinone and Chlorophyll Contents.","authors":"Rina Tanaka, Toshiyuki Shibata, Kosuke Yamamoto, Ryusuke Tanaka","doi":"10.3177/jnsv.71.118","DOIUrl":"https://doi.org/10.3177/jnsv.71.118","url":null,"abstract":"Terrestrial green plants are rich in phylloquinone (PK), and their PK content is highly correlated with the chlorophyll content. However, there are few studies on the PK content of algae and its correlation with chlorophyll content. To evaluate the PK content in algae and its correlation with chlorophyll, the PK and chlorophyll contents in algae, including Phaeophyta (18 species), Rhodophyta (17 species), and Chlorophyta (seven species), were determined. Algae, particularly Phaeophyta, contain more functional components than do other green terrestrial plants. Therefore, other components such as carotenoids, polyphenols, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability were analyzed to confirm their correlation with PK. Furthermore, terrestrial plants such as leafy vegetables, other vegetables, and tea powder were evaluated for the same components and compared with the experimental results for algae. This results showed that PK was abundant in Phaeophyta and almost all samples contained more than 100 μg/100 g of dry samples. In particular, Sargassum muticum contained 514.11±11.29 μg/100 g. However, almost all of the Rhodophyta and Chlorophyta contained a little PK. The results also confirmed a positive correlation between the PK and chlorophyll content in Rhodophyta (R2=0.7085), Chlorophyta (R2=0.7264), and terrestrial plants (R2=0.8436). However, no correlation was observed between the PK and chlorophyll content in Phaeophyta (R2=0.1013). In addition, the principal component analysis results showed no correlation between PK and other components, such as carotenoids and polyphenols, and DPPH radical scavenging ability in algae. However, Phaeophyta also contained more functional components, such as carotenoids, polyphenols, and DPPH radical scavenging ability than the other algal groups.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"118-132"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural and Functional Characteristics of FMN-Dependent NADPH-Indigo Reductase Homolog from Bacillus cohnii. 玉米芽孢杆菌fmn依赖性nadph -靛蓝还原酶同源物的结构和功能特征。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.180

Kazunari Yoneda, Haruhiko Sakuraba, Junji Hayashi, Yuki Naruse, Tomohiro Araki, Toshihisa Ohshima

引用次数: 0

Dietary Patterns Rich in Soybean Products, Vegetables, Fish, Fruits, and Miso Soup Were Inversely Associated with Fatty Liver Index: The Nagahama Study. 富含豆制品、蔬菜、鱼、水果和味噌汤的饮食模式与脂肪肝指数呈负相关：永滨研究。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.25

Yoko Ueba, Kaori Ikeda, Yasuharu Tabara, Takeo Nakayama, Daisuke Tanaka, Yoshimitsu Takahashi, Shinji Kosugi, Kazuya Setoh, Takahisa Kawaguchi, Fumihiko Matsuda, Nobuya Inagaki

{"title":"Dietary Patterns Rich in Soybean Products, Vegetables, Fish, Fruits, and Miso Soup Were Inversely Associated with Fatty Liver Index: The Nagahama Study.","authors":"Yoko Ueba, Kaori Ikeda, Yasuharu Tabara, Takeo Nakayama, Daisuke Tanaka, Yoshimitsu Takahashi, Shinji Kosugi, Kazuya Setoh, Takahisa Kawaguchi, Fumihiko Matsuda, Nobuya Inagaki","doi":"10.3177/jnsv.71.25","DOIUrl":"10.3177/jnsv.71.25","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prominent liver disease occurring in approximately 25% of the general population. As treatment, lifestyle modification is essential, but there are few reports on dietary patterns associated with MASLD except for the Mediterranean diet. This study examines dietary habits related to MASLD using the fatty liver index (FLI). Longitudinal analysis of a community-based cohort, the Nagahama Prospective Cohort for Comprehensive Human Bioscience, was performed. Dietary habits were assessed by a self-reported questionnaire on food intake frequency, and factor analysis was applied to identify dietary patterns. Multiple regression analysis was performed with baseline FLI or FLI after 5 y as the dependent variable and sex, age, and/or baseline FLI, and factor scores of each dietary pattern as simultaneous independent variables. The same analyses stratified by sex or body mass index (BMI) were also performed. Three thousand five hundred one participants were included. The 15 food items of the questionnaire were summarized into four dietary patterns. Dietary patterns rich in soybean products, vegetables, fish, fruits, and miso soup, which is characteristic of traditional Japanese diet, negatively correlated with FLI and FLI after 5 y (partial regression coefficient: -3.01 and -1.03, respectively; p<0.01 for both). The result was similar in sex-specific analysis and in BMI<23 kg/m2 group, when the participants were stratified according to BMI. Our results suggest that dietary patterns rich in soybean products, vegetables, fish, fruits, and miso soup are protective factors against MASLD especially in individuals with BMI<23 kg/m2.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"25-33"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0