{"title":"饲粮薄荷醇对低温环境下自主体温调节的影响。","authors":"Noriyuki Mori, Masumi Takano, Aya Nakashima, Eriko Inoue, Miki Yanai, Nanako Kondo, Asaka Maikuma","doi":"10.3177/jnsv.71.173","DOIUrl":null,"url":null,"abstract":"<p><p>Human body temperature homeostasis is regulated by both behavioral and autonomic thermoregulation. The transient receptor potential melastatin 8 (TRPM8) channel, a cold receptor, plays a critical role in cold perception and thermoregulation. Menthol, which activates TRPM8, has been shown to promote the \"browning\" of white adipocytes, enhancing thermogenesis. However, its effect on autonomic thermoregulation has remained unclear. To address this, the present study examines the influence of dietary menthol intake on autonomic thermoregulation in mice, with a focus on body temperature regulation under cold conditions. In this experiment, mice were fed diets containing 0.25% and 0.5% menthol for either 2 or 4 wk. The results indicated that the 0.5% menthol diet significantly reduced food intake, body weight, and visceral fat. In contrast, the 0.25% menthol diet showed no significant impact on these factors. Notably, mice treated with the 0.25% menthol diet for 4 wk suppressed the decrease in rectal and interscapular brown adipose tissue (IBAT) temperatures in a cold environment under anesthesia. Additionally, TRPM8 gene expression in IBAT was upregulated after 4 wk of 0.25% menthol diet consumption. These findings suggest that dietary menthol, especially at low concentrations, improves autonomic thermoregulation by activating TRPM8 without significantly affecting food intake or body weight.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"173-179"},"PeriodicalIF":0.7000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of Dietary Menthol on Autonomic Thermoregulation in a Cold Environment.\",\"authors\":\"Noriyuki Mori, Masumi Takano, Aya Nakashima, Eriko Inoue, Miki Yanai, Nanako Kondo, Asaka Maikuma\",\"doi\":\"10.3177/jnsv.71.173\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Human body temperature homeostasis is regulated by both behavioral and autonomic thermoregulation. The transient receptor potential melastatin 8 (TRPM8) channel, a cold receptor, plays a critical role in cold perception and thermoregulation. Menthol, which activates TRPM8, has been shown to promote the \\\"browning\\\" of white adipocytes, enhancing thermogenesis. However, its effect on autonomic thermoregulation has remained unclear. To address this, the present study examines the influence of dietary menthol intake on autonomic thermoregulation in mice, with a focus on body temperature regulation under cold conditions. In this experiment, mice were fed diets containing 0.25% and 0.5% menthol for either 2 or 4 wk. The results indicated that the 0.5% menthol diet significantly reduced food intake, body weight, and visceral fat. In contrast, the 0.25% menthol diet showed no significant impact on these factors. Notably, mice treated with the 0.25% menthol diet for 4 wk suppressed the decrease in rectal and interscapular brown adipose tissue (IBAT) temperatures in a cold environment under anesthesia. Additionally, TRPM8 gene expression in IBAT was upregulated after 4 wk of 0.25% menthol diet consumption. These findings suggest that dietary menthol, especially at low concentrations, improves autonomic thermoregulation by activating TRPM8 without significantly affecting food intake or body weight.</p>\",\"PeriodicalId\":16624,\"journal\":{\"name\":\"Journal of nutritional science and vitaminology\",\"volume\":\"71 2\",\"pages\":\"173-179\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of nutritional science and vitaminology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3177/jnsv.71.173\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of nutritional science and vitaminology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3177/jnsv.71.173","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Effects of Dietary Menthol on Autonomic Thermoregulation in a Cold Environment.
Human body temperature homeostasis is regulated by both behavioral and autonomic thermoregulation. The transient receptor potential melastatin 8 (TRPM8) channel, a cold receptor, plays a critical role in cold perception and thermoregulation. Menthol, which activates TRPM8, has been shown to promote the "browning" of white adipocytes, enhancing thermogenesis. However, its effect on autonomic thermoregulation has remained unclear. To address this, the present study examines the influence of dietary menthol intake on autonomic thermoregulation in mice, with a focus on body temperature regulation under cold conditions. In this experiment, mice were fed diets containing 0.25% and 0.5% menthol for either 2 or 4 wk. The results indicated that the 0.5% menthol diet significantly reduced food intake, body weight, and visceral fat. In contrast, the 0.25% menthol diet showed no significant impact on these factors. Notably, mice treated with the 0.25% menthol diet for 4 wk suppressed the decrease in rectal and interscapular brown adipose tissue (IBAT) temperatures in a cold environment under anesthesia. Additionally, TRPM8 gene expression in IBAT was upregulated after 4 wk of 0.25% menthol diet consumption. These findings suggest that dietary menthol, especially at low concentrations, improves autonomic thermoregulation by activating TRPM8 without significantly affecting food intake or body weight.
期刊介绍:
The Journal of Nutritional Science and Vitaminology is an international medium publishing in English of original work in all branches of nutritional science, food science and vitaminology from any country.
Manuscripts submitted for publication should be as concise as possible and must be based on the results of original research or of original interpretation of existing knowledge not previously published. Although data may have been reported, in part, in preliminary or
abstract form, a full report of such research is unacceptable if it has been or will be submitted for consideration by another journal.