Journal of nutritional science and vitaminology最新文献_第8页

On the Relationship between MMA Levels in Blood Products and Donor Sex, Age, and Donation Frequency. 血液制品中 MMA 含量与献血者性别、年龄和献血次数的关系。

IF 1.6 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.124

Fei Li, Aiwei Zhu, Caixia Huang, Hui Guo, Lingling Zhu, Hua Zhuang, Suochun Cao

{"title":"On the Relationship between MMA Levels in Blood Products and Donor Sex, Age, and Donation Frequency.","authors":"Fei Li, Aiwei Zhu, Caixia Huang, Hui Guo, Lingling Zhu, Hua Zhuang, Suochun Cao","doi":"10.3177/jnsv.70.124","DOIUrl":"https://doi.org/10.3177/jnsv.70.124","url":null,"abstract":"As the aging process accelerates, the age structure of blood donors turns to older and even aged groups. Methylmalonic acid (MMA), a byproduct of propionate metabolism, may be upregulated in the serum of older adults. As a mediator of chronic disease and tumor progression, the MMA content in blood products has become the focus of research. Absolute concentrations of MMA in blood products were determined based on the liquid chromatography-tandem mass spectrometry, so as to analyze how they were affected by donors' age, sex, and frequency of blood donation. The MMA content in leukocyte-depleted suspended red blood cell (lds-RBC) was significantly higher than that in fresh plasma (p<0.0001). The MMA content among five age groups showed no difference in either fresh plasma or lds-RBCs. The MMA content in fresh plasma was similar in the parameters of the sex, whereas that in lds-RBCs was higher in males than that in females (p=0.035). There were no significant differences in MMA content when it comes to different frequencies of blood donors in either fresh plasma or lds-RBCs. Additionally, there was no significant difference or clear trend in the rate of elevated plasma MMA levels among different sexes, age groups, and blood donation frequency groups. MMA in the blood products from donors in China does not compromise the safety of blood transfusions for cancer patients. Nevertheless, there is a need to focus on MMA levels in Chinese and to develop race-specific and age-specific normal reference ranges.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 2","pages":"124-130"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alfacalcidol-Induced Kidney Injury in Patients with Severe Motor and Intellectual Disabilities. 阿法骨化醇诱发严重运动障碍和智力障碍患者的肾损伤。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.365

Osamu Uemura, Yuka Hasegawa, Hideaki Nakashima, Kiyomi Hattori, Mari Koduka, Yoshihiro Otobe

{"title":"Alfacalcidol-Induced Kidney Injury in Patients with Severe Motor and Intellectual Disabilities.","authors":"Osamu Uemura, Yuka Hasegawa, Hideaki Nakashima, Kiyomi Hattori, Mari Koduka, Yoshihiro Otobe","doi":"10.3177/jnsv.70.365","DOIUrl":"https://doi.org/10.3177/jnsv.70.365","url":null,"abstract":"Patients with severe motor and intellectual disabilities (SMID) often experience insufficient physical activity, leading to osteoporosis. The active form of vitamin D is commonly prescribed for the prevention or treatment of osteoporosis. We observed four cases of kidney injury believed to be associated with the administration of 1α-OH vitamin D (alfacalcidol) preparations. This study employed a case series design to investigate change in kidney function in SMID patients following administration or discontinuation of alfacalcidol. We retrospectively analyzed data of 23 SMID patients (sex: 10 males, 13 females; age range: 27 to 74 y), and assessed kidney function, serum calcium, and albumin levels. Data was grouped into A: 16 cases collected both before starting alfacalcidol administration and during alfacalcidol administration; and into B: 11 cases collected during alfacalcidol administration and after discontinuation of alfacalcidol administration. Of the 23 patients, four were assigned into both group A and group B. Of the 16 cases in group A, six showed ≥30% decreased kidney function. Of the 11 cases in group B, the median values of modified Cr-eGFR were 43.0 and 65.1 mL/min/1.73 m2, respectively (p=0.008), indicating a significant improvement in kidney function. It is essential for practitioners to understand that osteoporosis may ordinarily occur in SMID patients due to reduced bone stimulation. Thus caution must be exercised when administering active vitamin D preparations to this population, as they carry a risk of kidney organ damage despite having no direct effect on bone health.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 5","pages":"365-369"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Cereal Consumption (Frugra^®) on Autonomic Nervous System Function in Healthcare Workers Who Skip Breakfast. 食用谷物 (Frugra®) 对不吃早餐的医护人员自主神经系统功能的影响。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.380

Hideki Ebina, Tomotaka Dohi, Yoshifumi Fukushima, Kosuke Fukao, Takatoshi Kasai, Seiji Ueda, Satoshi Matsushita, Atsushi Amano, Tohru Minamino

{"title":"Effect of Cereal Consumption (Frugra®) on Autonomic Nervous System Function in Healthcare Workers Who Skip Breakfast.","authors":"Hideki Ebina, Tomotaka Dohi, Yoshifumi Fukushima, Kosuke Fukao, Takatoshi Kasai, Seiji Ueda, Satoshi Matsushita, Atsushi Amano, Tohru Minamino","doi":"10.3177/jnsv.70.380","DOIUrl":"https://doi.org/10.3177/jnsv.70.380","url":null,"abstract":"In this study, we aimed to clarify the effects of breakfast intervention on autonomic nerve function in healthcare workers who skip breakfast. This cross-sectional, interventional study was conducted between January 2020 and December 2021. All participants were full-time healthcare workers who completed a self-administered questionnaire on fatigue and subjective symptoms and underwent noninvasive autonomic nerve function tests. \"Skippers\" were defined as individuals who ate breakfast <4 times per week, and \"eaters\" were those who ate breakfast >4 times per week. We introduced a cereal, Frugra (Calbee, Inc.), to skippers who opted for the breakfast intervention. Subsequently, they completed the questionnaire again and repeated the autonomic nerve function tests. Among 196 participants (age [mean±SD]: 29.8±7.8 y; 177 women and 19 men), 120 were categorized as skippers and 76 as eaters. In the skipper group, more participants were nurses, lived alone, and worked the night shift than in the eater group. The Chalder Fatigue Scale (CFS) score in the skipper group was higher than that in the eater group, although not significantly. Regarding autonomic nerve function, no significant differences were observed between the groups. In 50 skippers who opted for the breakfast intervention, the CFS score significantly decreased after 4 wk. Log low frequency and log coefficient of component variance total power significantly increased, whereas log high frequency increased, but not significantly, after the intervention. In conclusion, for healthcare workers who were breakfast skippers, the consumption of breakfast cereal reduced their fatigue level and improved their autonomic nervous system activity.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 5","pages":"380-386"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nitrate and Nitrite Concentrations in Fingertip Serum Following Beetroot Juice Ingestion Correlate with Those in Venous Plasma. 摄入甜菜根汁后指尖血清中的硝酸盐和亚硝酸盐浓度与静脉血浆中的硝酸盐和亚硝酸盐浓度相关。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.441

Naoto Fujii, Shin Omori, Yufuko Kataoka, Takeshi Nishiyasu, Naomi Omi

{"title":"Nitrate and Nitrite Concentrations in Fingertip Serum Following Beetroot Juice Ingestion Correlate with Those in Venous Plasma.","authors":"Naoto Fujii, Shin Omori, Yufuko Kataoka, Takeshi Nishiyasu, Naomi Omi","doi":"10.3177/jnsv.70.441","DOIUrl":"https://doi.org/10.3177/jnsv.70.441","url":null,"abstract":"Dietary nitrate (NO3-) supplementation can offer health benefit and improve exercise performance by increasing nitric oxide (NO) through NO3--nitrite (NO2-)-NO pathway. Individuals may benefit from dietary NO3- supplementation by monitoring blood [NO3-] and [NO2-], although a simple and practical method for assessing blood [NO3-] and [NO2-] has not been established. We examined whether fingertip serum samples could substitute for venous plasma samples in assessing [NO3-] and [NO2-]. Ten young adults consumed 140 mL of nitrate-rich beetroot juice. Fingertip serum and venous plasma samples were collected at baseline and every hour for up to 4 h after ingestion. [NO3-] and [NO2-] were similar between samples at baseline, whereas they were higher in fingertip serum throughout the post-ingestion periods. Significant correlations existed between fingertip serum vs. venous plasma for both [NO3-] and [NO2-] throughout post-drink periods, except [NO3-] assessed at 2 and 4 h after ingestion of beetroot juice. We show that although fingertip serum [NO3-] and [NO2-] overestimate those measured by venous plasma after dietary NO3- intake (125-141% and 156-183% of venous values), [NO3-] and [NO2-] in fingertip serum samples may be utilized for assessing blood [NO3-] and [NO2-] levels, although [NO3-] assessment may lack precision compared to [NO2-].","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 5","pages":"441-444"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vegetable and Fruit Intake and LOX-Index in Japanese Municipal Workers. 日本市政工人的蔬菜和水果摄入量与 LOX 指数。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.396

Mirai Sakanari, Masanori Ohta, Mayumi Nagano, Yoko Umeki, Akiko Nanri

{"title":"Vegetable and Fruit Intake and LOX-Index in Japanese Municipal Workers.","authors":"Mirai Sakanari, Masanori Ohta, Mayumi Nagano, Yoko Umeki, Akiko Nanri","doi":"10.3177/jnsv.70.396","DOIUrl":"10.3177/jnsv.70.396","url":null,"abstract":"Vegetable and fruit intake has been reported to be associated with decreased risk of cardiovascular disease. To date, however, no study has examined the association between vegetable and fruit intake and LOX-index, which reflects the progression of atherosclerosis and is a predictive biomarker of stroke and coronary heart disease. Here, we examined the cross-sectional association between vegetable and fruit intake and LOX-index in Japanese municipal workers. Participants were 338 workers (166 men and 172 women aged 19-71 y) with no history of serious disease who participated in a health and nutrition survey. Vegetable and fruit intake was assessed using a validated brief self-administered diet history questionnaire. LOX-index was calculated by multiplying serum concentrations of the soluble form of lectin-like oxidized LDL receptor-1 by those of LOX-1 ligands containing apolipoprotein B. Multiple regression analysis was used to estimate the geometric mean of LOX-index according to tertile of vegetable and/or fruit intake. Total vegetable and fruit intake was associated with a trend toward decreased LOX-index after adjustment for covariates (p for trend=0.067). In stratified analyses by sex, a significant inverse association between total vegetable and fruit intake and LOX-index was observed in women (p for trend=0.023), whereas such association was not observed in men (p for trend=0.70). None of the intakes of vegetables, fruit, green and yellow vegetables, or other vegetables was associated with LOX-index. Our results suggest that higher intake of total vegetables and fruit is associated with a lower LOX-index in Japanese women.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 5","pages":"396-405"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ameliorative Effect of Raspberry Ketone on Hypothalamic Inflammation in High Fat Diet-Induced Obese Mice. 树莓酮对高脂饮食诱导的肥胖小鼠下丘脑炎症的改善作用。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.496

Zhao Yao, Zhenhua Zhu, Xingyou Chen, Xiaoping Li

{"title":"Ameliorative Effect of Raspberry Ketone on Hypothalamic Inflammation in High Fat Diet-Induced Obese Mice.","authors":"Zhao Yao, Zhenhua Zhu, Xingyou Chen, Xiaoping Li","doi":"10.3177/jnsv.70.496","DOIUrl":"https://doi.org/10.3177/jnsv.70.496","url":null,"abstract":"This study aimed to investigate the regulatory effects of raspberry ketone on hypothalamic inflammation and its mechanism. Mouse microglia cells (BV2 cells) were cultured in vitro with palmitic acid (100 μM) to induce inflammation model and then incubated with raspberry ketone (5, 20, 50 μM) alone or raspberry ketone (50 μM) and the specific inhibitor of uncoupling protein 2 (UCP2), genipin (10 μM), to test the role of UCP2 in raspberry ketone regulatory of inflammation. Meanwhile, C57BL/6J mice were fed a high-fat diet containing raspberry ketone (0.2%, wt/wt) for 16 wk or 7 d to observe the effects of raspberry ketone on the body weights and hypothalamic inflammation of mice. The expression levels of inflammatory factors, including interleukin-6 (IL-6), interleukin-1beta (IL-1β) and tumour necrosis factor alpha (TNF-α), were detected using RT-qPCR, Elisa, and Western blotting, respectively. At the cellular level, raspberry ketone reduced the content of inflammatory factors in BV2 cells and in the cell culture medium. Genipin inhibited the anti-inflammatory effect of raspberry ketone on BV2 cells. At the animal level, after 16 wk of feeding, raspberry ketone-containing diets significantly reduced the body weight of mice, but had no significant effect on the mRNA expression level of hypothalamic inflammatory factors. On the other hand, 7 d of raspberry ketone gavage significantly reduced mRNA and protein expression of hypothalamic inflammatory factors. The results of this study suggest that raspberry ketone could regulate high-fat diet-induced obesity in mice, and the specific mechanism may be to inhibit hypothalamic inflammation in mice by regulating UCP2 gene expression.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 6","pages":"496-502"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Mixed Solid Food and Water Intake on Blood Glucose Level and Energy Metabolism. 固体食物和水混合摄入对血糖水平和能量代谢的影响。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.490

Takuro Tobina, Kaori Nakamine, Shouhei Takeuchi, Rie Tomiga-Takae, Katsuhisa Omagari, Tomoki Yamashita

{"title":"Effect of Mixed Solid Food and Water Intake on Blood Glucose Level and Energy Metabolism.","authors":"Takuro Tobina, Kaori Nakamine, Shouhei Takeuchi, Rie Tomiga-Takae, Katsuhisa Omagari, Tomoki Yamashita","doi":"10.3177/jnsv.70.490","DOIUrl":"https://doi.org/10.3177/jnsv.70.490","url":null,"abstract":"Carbohydrate-rich solid foods, such as bread, pasta, and steamed rice, are applied for test meals in studies examining digestion and absorption of food related to glucose metabolism and sports science. Such research must consider that drinking water is sometimes better as it avoids the risk of choking or aspiration. However, the water increases test meal volume and dilutes glucose concentration, which may influence the digestion and absorption of ingested foods, as well as energy metabolism. Therefore, this study aimed to investigate whether the peak time and concentration of glucose and energy metabolism will differ among the intake of steamed rice alone (Rice), simultaneous intake of steamed rice and water (Mixed), and water alone (Water). Following the intake of the test meals, there was an immediate increase in blood glucose in Mixed compared to Rice and Water. The glucose peak time of Rice (60 (56-68) min; median and quartile) was also delayed compared to Mixed (38 (29-45) min). The blood lactate peak time was also significantly different in Mixed and Rice. Although meal and time interaction was not found in energy expenditure, Mixed increases the respiratory quotient by 40 min compared to Water. In conclusion, this study demonstrated that simultaneous intake of steamed rice and water hasted digestion and absorption of glucose and activates glycolysis. Future studies investigating gastric emptying rate and glucose metabolism should ensure that the conditions of fluid intake and the test meal volumes are consistent and do not differ significantly.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 6","pages":"490-495"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Summer Nutritional Status and Appetite Are Associated with the Frequency of Hot Meal/Drink Intake among Japanese Older People. 日本老年人的夏季营养状况和食欲与热餐/热饮摄入频率有关。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.288

Kyoko Fujihira, Masaki Takahashi, Ai Iizuka, Hiroyuki Suzuki, Naoyuki Hayashi

{"title":"Summer Nutritional Status and Appetite Are Associated with the Frequency of Hot Meal/Drink Intake among Japanese Older People.","authors":"Kyoko Fujihira, Masaki Takahashi, Ai Iizuka, Hiroyuki Suzuki, Naoyuki Hayashi","doi":"10.3177/jnsv.70.288","DOIUrl":"https://doi.org/10.3177/jnsv.70.288","url":null,"abstract":"This study examined the relationship between the frequency of consuming cold or hot meal/drink during summer and the nutritional status, appetite, and energy intake among Japanese older people. The cross-sectional study was conducted in August 2021, targeting 60 adults aged 65 y and older. The Mini Nutritional Assessment (MNA) was used for nutritional status evaluation, the Simplified Nutritional Appetite Questionnaire (SNAQ) for appetite scoring, and food frequency questionnaire to assess energy intake. Participants reported on the frequency of consuming cold or hot meal/drink during the summer. Those who reported consuming hot meals \"moderate\" (p=0.033) or \"frequent\" (p=0.005) during summer had a higher BMI than those who reported minimal consumption. Participants who reported \"frequent\" consumption of hot meals in summer had higher MNA scores than those who reported \"minimal\" consumption (p=0.014). Participants who reported a \"frequent\" consumption of hot meals had higher SNAQ scores compared to those who reported \"minimal\" (p<0.001) or \"moderate\" (p=0.001). Similarly, participants who reported a \"frequent\" consumption of hot drinks had higher SNAQ scores than those reporting \"minimal\" (p=0.021) or \"moderate\" (p=0.008). The nutritional status and appetite during summer in Japanese older people were associated with the frequency of consuming hot meals and drinks.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 3","pages":"288-292"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Oleuropein on Anti-Obesity and Uncoupling Protein 1 Level in Brown Adipose Tissue in Mild Treadmill Walking Rats with Diet-Induced Obesity. 油菜素对轻度跑步机行走肥胖大鼠抗肥胖和棕色脂肪组织中解偶联蛋白1水平的影响

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.193

Yuriko Oi-Kano, Tsuyoshi Goto, Haruya Takahashi, Yusaku Iwasaki, Teruo Kawada

{"title":"Effect of Oleuropein on Anti-Obesity and Uncoupling Protein 1 Level in Brown Adipose Tissue in Mild Treadmill Walking Rats with Diet-Induced Obesity.","authors":"Yuriko Oi-Kano, Tsuyoshi Goto, Haruya Takahashi, Yusaku Iwasaki, Teruo Kawada","doi":"10.3177/jnsv.70.193","DOIUrl":"10.3177/jnsv.70.193","url":null,"abstract":"Oleuropein aglycone (OA), which is the absorbed form of oleuropein, is a major phenolic compound in extra virgin olive oil. We analyzed the anti-obesity effect of OA intake combined with mild treadmill walking (MTW, 4 m/min for 20 min/d, 5-6 d/wk, without electric shocks and slope) in rats under a high-fat diet (HF). Four-week-old male Sprague-Dawley rats (n=28) were equally divided into four groups: control (HF), 0.08% oleuropein-supplemented HF (HFO), HF with MTW (HF+W), and HFO with MTW (HFO+W) groups. After 28 d, the inguinal subcutaneous fat content and weight gain were significantly lower in the HFO+W group than in the control group. The HFO+W group also had significantly higher levels of urinary noradrenaline secretion, interscapular brown adipose tissue, uncoupling protein 1, brain transient receptor potential ankyrin subtype 1 (TRPA1), vanilloid subtype 1 (TRPV1), and brain-derived neurotrophic factor (BDNF) than the control group. Especially, the HFO+W group showed a synergistic effect on noradrenaline secretion. Therefore, OA combined with MTW may accelerate the enhancement of UCP1 and BDNF levels in rats with HF-induced obesity by increasing noradrenaline secretion after TRPA1 and TRPV1 activation.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 3","pages":"193-202"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Muscle-Protective Effect of Carnosine against Dexamethasone-Induced Muscle Atrophy in C2C12 Myotube. 肉碱对地塞米松诱导的 C2C12 肌管肌肉萎缩的保护作用

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.219

Md Mizanur Rahman, Anayt Ulla, Hiroki Moriwaki, Yusuke Yasukawa, Takayuki Uchida, Takeshi Nikawa

{"title":"Muscle-Protective Effect of Carnosine against Dexamethasone-Induced Muscle Atrophy in C2C12 Myotube.","authors":"Md Mizanur Rahman, Anayt Ulla, Hiroki Moriwaki, Yusuke Yasukawa, Takayuki Uchida, Takeshi Nikawa","doi":"10.3177/jnsv.70.219","DOIUrl":"https://doi.org/10.3177/jnsv.70.219","url":null,"abstract":"This study investigated the protective effect of carnosine and its components (L-histidine and β-alanine [HA]) against dexamethasone (Dex)-induced muscle atrophy in C2C12 myotubes. Myotubes were treated with Dex (10 μM) to induce muscle atrophy manifested by decreased myotube diameter, low myosin heavy chain content, and increased expression of muscle atrophy-associated ubiquitin ligases (Atrogin-1, MuRF-1, and Cbl-b). Carnosine (20 mM) treatment significantly improved the myotube diameter and MyHC protein expression level in Dex-treated C2C12 myotubes. It also downregulated the expression of Atrogin-1, MuRF-1, and Cbl-b and suppressed the expression of forkhead box O3 (FoxO3a) mediated by Dex. Furthermore, reactive oxygen species production was increased by Dex but was ameliorated by carnosine treatment. However, HA (20 mM), the component of carnosine, treatment was found ineffective in preventing Dex-induced protein damage. Therefore, based on above results it can be suggested that carnosine could be a potential therapeutic agent to prevent Dex-induced muscle atrophy compared to its components HA.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 3","pages":"219-227"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0