Journal of nutritional science and vitaminology最新文献_第8页

Adult Chicken Bone-Derived Components Reverse the Impaired Calcium Homeostasis and Bone Mass in Mice Lacking 1,25(OH)₂D₃-VDR Signaling. 成年鸡骨源性成分逆转缺乏1,25(OH)2D3-VDR信号的小鼠钙稳态和骨量受损

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.81

Tamao Nishiura, Hitoki Yamanaka, Risako Mori, Shigeaki Kato, Masato Nakane, Satoshi Kotoura, Ritsuko Masuyama

{"title":"Adult Chicken Bone-Derived Components Reverse the Impaired Calcium Homeostasis and Bone Mass in Mice Lacking 1,25(OH)2D3-VDR Signaling.","authors":"Tamao Nishiura, Hitoki Yamanaka, Risako Mori, Shigeaki Kato, Masato Nakane, Satoshi Kotoura, Ritsuko Masuyama","doi":"10.3177/jnsv.71.81","DOIUrl":"10.3177/jnsv.71.81","url":null,"abstract":"Female adult chickens, known as laying hens, possess a distinctive bone structure in the intracortical region, which is responsible for storing calcium. Given the cyclical nature of calcium storage and demand during the egg-laying cycle, the medullary bone of laying hens plays a crucial role in maintaining calcium homeostasis. In this study, we examined the potential of orally administered components derived from adult chicken bones to improve calcium homeostasis and bone mass in mice. Samples from adult chickens and young chickens without egg-laying experience were prepared by pressing meat parts, including bones, and administered to wild type (WT) and vitamin D receptor knockout (VDRKO) mice respectively. The phenotypes observed in VDRKO mice, such as severe reductions in serum calcium concentration and bone mass, were normalized in mice fed the adult chicken bone-containing diet to the same extent as in WT mice. These effects were not observed in mice fed a young chicken bone-containing diet. The adult chicken bone-containing diet increased apparent calcium absorption in VDRKO mice compared to other dietary groups. To determine the effects on bone metabolism, osteoclasts activity was evaluated by histological measurements and the quantification of serum osteoclast marker, and it was restored by the adult chicken bone-containing diet. In addition, the treatment of adult chicken bone-derived components increased osteoclasts differentiation in vitro from cultured bone marrow macrophage. These results show that adult chicken bone-derived components improve calcium and bone homeostasis in mice lacking vitamin D action through combined effects that target calcium metabolism and bone turnover.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"81-92"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Factors of Malnutrition in Nasopharyngeal Carcinoma Patients Undergoing Radiotherapy and Construction of a Predictive Model. 鼻咽癌放疗患者营养不良的危险因素及预测模型的建立

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.537

Chaohui Zhan, Zhixun Gong, Nannan Ji, Xinmei Ju

{"title":"Risk Factors of Malnutrition in Nasopharyngeal Carcinoma Patients Undergoing Radiotherapy and Construction of a Predictive Model.","authors":"Chaohui Zhan, Zhixun Gong, Nannan Ji, Xinmei Ju","doi":"10.3177/jnsv.71.537","DOIUrl":"https://doi.org/10.3177/jnsv.71.537","url":null,"abstract":"Malnutrition is a common and serious complication in patients undergoing radiotherapy for nasopharyngeal carcinoma (NPC). This study aimed to identify risk factors for malnutrition and to construct and validate a predictive model to aid early detection. A total of 158 NPC patients treated with radiotherapy at the Second Affiliated Hospital of Hainan Medical University between March 2023 and November 2024 were retrospectively analyzed. Demographic, clinical, and biochemical data were collected, and nutritional status was assessed using the Patient-Generated Subjective Global Assessment (PG-SGA). Patients were classified as malnourished or non-malnourished, and potential predictors were evaluated using Least Absolute Shrinkage and Selection Operator (LASSO) regression followed by multivariable logistic regression. Among all patients, 118 (74.7%) developed malnutrition. Nutritional support and total protein were identified as independent protective factors, while dysphagia emerged as an independent risk factor. A nomogram incorporating these factors demonstrated strong discriminatory ability (AUC=0.964), good calibration, and clinical utility across threshold probabilities of 0.2-1.0 as shown by decision curve analysis. These findings indicate that malnutrition is highly prevalent in NPC patients undergoing radiotherapy and highlight the importance of nutritional support and protein status in reducing risk. The developed model offers a practical tool for early screening and targeted intervention in clinical practice.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 6","pages":"537-543"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contents of Volume 71. 第71卷的内容。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.578

引用次数: 0

The Effect of Heat-Killed Lacticaseibacillus paracasei K71 on Abdominal Fat Reduction: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparative Trial. 热杀副干酪乳杆菌K71对腹部脂肪减少的影响：一项随机、双盲、安慰剂对照、平行组比较试验。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.486

Kana Yamamoto-Yamaya, Yoshie Senda-Sugimoto, Toshihiro Mihara, Jiro Saito, Yuki Higuchi, Hajime Takahashi

{"title":"The Effect of Heat-Killed Lacticaseibacillus paracasei K71 on Abdominal Fat Reduction: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparative Trial.","authors":"Kana Yamamoto-Yamaya, Yoshie Senda-Sugimoto, Toshihiro Mihara, Jiro Saito, Yuki Higuchi, Hajime Takahashi","doi":"10.3177/jnsv.71.486","DOIUrl":"10.3177/jnsv.71.486","url":null,"abstract":"It has been confirmed that Lacticaseibacillus paracasei (formerly designated as Lactobacillus paracasei: L. paracasei) K71, a lactic acid bacterium isolated from sakekasu (sake lees) has immunomodulatory and anti-obesity effects. This study aimed to investigate the effect of heat-killed L. paracasei K71 intake on reducing abdominal fat in a randomized, double-blind, placebo-controlled, parallel-group comparative trial. Eighty healthy male and female subjects with a BMI of ≥23 and <30 were selected and randomly assigned to one of two groups, a test food group and a placebo group. Subjects ingested either a test food containing 50 mg (approximately 1×1011 bacteria) of heat-killed L. paracasei K71 or a placebo for 12 wk. Abdominal fat area and volume, as calculated by computed tomography, body weight, BMI, body fat percentage, waist circumference, hip circumference, waist-to-hip ratio, and blood markers were evaluated. In PPS, no significant between-group differences were observed in any item. On the other hand, in subjects with no significant changes in lifestyle, compared with the placebo group, the test food group showed significant decreases in subcutaneous fat area, visceral fat volume, subcutaneous fat volume, body fat percentage, and hip circumference after 12 wk. Moreover, no adverse events due to the test food containing heat-killed L. paracasei K71 were observed during the test period. These results suggest that continuous intake of heat-killed L. paracasei K71 has the effect of reducing abdominal fat in healthy subjects with a high BMI. This trial was registered at UMIN-CTR (UMIN000051324).","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 5","pages":"486-497"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of α- and δ-Tocotrienol on Human Airway Smooth Muscle Cells~Tocotrienols as Potential Candidates for the Treatment of Airway Remodeling in Asthma. α-和δ-生育三烯醇对人气道平滑肌细胞的影响~生育三烯醇作为治疗哮喘气道重塑的潜在候选者。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.300

Ryota Okazaki, Aditya Sri Listyoko, Tomoya Harada, Miki Takata, Masato Morita, Hiroki Ishikawa, Yoshihiro Funaki, Genki Inui, Akira Yamasaki

{"title":"Effect of α- and δ-Tocotrienol on Human Airway Smooth Muscle Cells~Tocotrienols as Potential Candidates for the Treatment of Airway Remodeling in Asthma.","authors":"Ryota Okazaki, Aditya Sri Listyoko, Tomoya Harada, Miki Takata, Masato Morita, Hiroki Ishikawa, Yoshihiro Funaki, Genki Inui, Akira Yamasaki","doi":"10.3177/jnsv.71.300","DOIUrl":"https://doi.org/10.3177/jnsv.71.300","url":null,"abstract":"Tocotrienols are members of the vitamin E family and exhibit antioxidant properties, immunomodulatory effects, and anti-inflammatory actions. Previously, we demonstrated that γ-tocotrienol inhibits human airway smooth muscle (ASM) cell proliferation, migration, contractile phenotype expression, and extracellular matrix protein synthesis by suppressing RhoA activation. In this study, we investigated whether α- or δ-tocotrienol modulates transforming growth factor-beta 1 (TGF-β1)-induced contractile phenotype expression in human ASM cells and platelet-derived growth factor-BB (PDGF-BB)-induced proliferation and migration of ASM cells. Human ASM cells were pretreated with α- or δ-tocotrienol before stimulation with PDGF-BB to promote proliferation and migration or with TGF-β1 to induce smooth muscle actin expression. PDGF-BB-stimulated ASM cell proliferation and migration were assessed using colorimetric and transwell migration assays. Additionally, we examined the signaling pathways involved in the effects of α- or δ-tocotrienol on PDGF-BB-induced ASM proliferation and migration, as well as TGF-β1-induced smooth muscle actin expression. TGF-β1 increased α-smooth muscle actin expression in human ASM cells. Treatment with α- and δ-tocotrienol slightly reduced α-smooth muscle actin levels, though this reduction was not statistically significant. In contrast, PDGF-BB-induced ASM cell proliferation and migration were significantly inhibited by α- and δ-tocotrienol treatment. The effects of α- and δ-tocotrienol on ASM proliferation and migration involve the RhoA signaling pathway and a reduction in reactive oxygen species (ROS) production. These findings suggest that α- and δ-tocotrienol exert beneficial effects on airway remodeling in asthma by inhibiting the proliferation and migration of human ASM cells.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 4","pages":"300-311"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D Deficiency Is Associated with an Increased Risk of Macroalbuminuria in Chinese Patients with Type 2 Diabetes. 维生素D缺乏与中国2型糖尿病患者大量蛋白尿风险增加有关

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.283

Xiulin Wang, Wenjin Xiao

{"title":"Vitamin D Deficiency Is Associated with an Increased Risk of Macroalbuminuria in Chinese Patients with Type 2 Diabetes.","authors":"Xiulin Wang, Wenjin Xiao","doi":"10.3177/jnsv.71.283","DOIUrl":"10.3177/jnsv.71.283","url":null,"abstract":"This research examines the correlation between serum 25-hydroxyvitamin D [25(OH)D] levels and albuminuria. A total of 203 hospitalized patients diagnosed with type 2 diabetes mellitus (T2DM) were selected from February to October 2023 and categorized into groups according to their urine albumin-to-creatinine ratio (UACR). Spearman correlation analysis and multiple regression analysis were used to assess the relationship between 25(OH)D and UACR. Among the 203 T2DM patients included, the prevalence of vitamin D deficiency was 59.1%. The 25(OH)D levels in the macroalbuminuria group 9.37 ng/mL (5.98, 15.60) were significantly lower than those in the normal albuminuria group 18.26 ng/mL (14.40, 23.52) and microalbuminuria group 18.20 ng/mL (11.71, 24.20) with statistical significance (p<0.001). Spearman correlation analysis showed a negative correlation between serum 25(OH)D and UACR (r=-0.173, p=0.014). Stepwise linear regression analysis, after adjusting for confounding factors, revealed a linear negative correlation between 25(OH)D and albuminuria (β=-0.278, p<0.001). In the multivariable logistic regression analysis, no association was identified between vitamin D deficiency and microalbuminuria in patients with T2DM. However, vitamin D deficiency may significantly increase the risk of macroalbuminuria in patients with T2DM,with an odds ratio (OR) of 4.747 (95% CI: 1.157-19.473). Vitamin D deficiency is prevalent among the study population. Serum 25(OH)D levels exhibited a significant negative correlation with UACR, suggesting a relationship between vitamin D deficiency and an elevated risk of macroalbuminuria in individuals with T2DM.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 4","pages":"283-289"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modified Irwin Test with Single Intravenous Administration of Caffeine in Mice. 小鼠单次静脉给药改良欧文试验。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.267

Sung-Hyun Cho, Su-Jeong Kim, Caglar Doguer, Miae Doo, Jung-Heun Ha

引用次数: 0

Association between Screen Time and Lifestyle Habits among Upper Elementary School Children. 小学高年级儿童屏幕时间与生活习惯的关系

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.248

Asami Baba, Rikako Yoshitake, Yumiko Inose, Naomi Omi

{"title":"Association between Screen Time and Lifestyle Habits among Upper Elementary School Children.","authors":"Asami Baba, Rikako Yoshitake, Yumiko Inose, Naomi Omi","doi":"10.3177/jnsv.71.248","DOIUrl":"https://doi.org/10.3177/jnsv.71.248","url":null,"abstract":"This cross-sectional study examined the link between screen time and lifestyle habits in upper elementary school children. It included 400 elementary schoolchildren studying in the fifth and sixth grades in elementary (187 boys, 213 girls, age: 10-12 y) in Japan. Gender, obesity index, physical fitness score, screen time, and lifestyle habits related to breakfast, midnight snacks, exercise, and sleep were the study items. Using logistic regression analysis, we examined lifestyle habits factors and screen time as the dependent and independent variables, respectively. We found that >3 h of screen time was significantly associated with increased odds of eating breakfast sometimes or never (odds ratio [95% confidence interval] 2.37 [1.05, 5.38]) and eating midnight snacks (2.72 [1.41, 5.23]). Additionally, the same factor significantly associated with <6 h of sleep (10.45 [2.78, 39.30]) and bedtime later than 10 pm (2.81 [1.43, 5.53]) and 11 pm (3.97 [1.95, 8.07]). These results hold true even after accounting for demographics, obesity index, and physical fitness score. Conversely, 2-3 h of screen time was significantly associated with sleep onset conditions (2.05 [1.17, 3.58]), whereas >3 h of screen time was not. Our results showed that increased screen time was associated with skipping breakfast, midnight snacks, sleep onset conditions, and less bedtime.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 3","pages":"248-255"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Blue Rose Extract Powder Intake on Skin Characteristics in Middle-Aged and Older Japanese Women-Randomized, Double-Blind, and Placebo-Controlled Trial. 蓝玫瑰提取物粉摄入对日本中老年妇女皮肤特征的影响：随机、双盲、安慰剂对照试验

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.163

Daisuke Aoyagi, Tomoe Yamada-Kato, Isao Okunishi

{"title":"Effects of Blue Rose Extract Powder Intake on Skin Characteristics in Middle-Aged and Older Japanese Women-Randomized, Double-Blind, and Placebo-Controlled Trial.","authors":"Daisuke Aoyagi, Tomoe Yamada-Kato, Isao Okunishi","doi":"10.3177/jnsv.71.163","DOIUrl":"https://doi.org/10.3177/jnsv.71.163","url":null,"abstract":"In this study, we aimed at evaluating the effect of improving skin conditions on petal-derived blue rose extract (BRE) powder intake in middle-aged and older women in Japan. We conducted a randomized, double-blind, and placebo-controlled parallel study in 48 healthy Japanese women aged 40-50 y who were aware of dry skin. We divided the participants equally into two groups (i.e., 24-24 in the test and control groups, respectively). The participants consumed 100 mg either the placebo or BRE powder daily for 4 wk. We performed skin measurements before-and-after 4 wk of continuous intake. Upon 4 wk after continuous intake, the BRE group displayed improved skin quality compared with the control group. The primary outcome was stratum corneum water content, which significantly improved in the BRE group. The secondary outcomes, melanin index, stains, wrinkles, and rough texture showed improvements between the groups as well. Visual perception, roughness of texture, and wrinkles were improved between the groups. Finally, transparency yielded better scores within the groups. This study presents the results of the first functional test targeting BRE, unraveling various effect of improving skin condition and highlighting the potential of taking BRE in skin care.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"163-172"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between the Intakes of Plant Foods and Coronary Artery Disease in Japanese Patients Undergoing Coronary Angiography. 在接受冠状动脉造影的日本患者中，植物性食物摄入与冠状动脉疾病之间的关系

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.93

Emi Saita, Yoshimi Kishimoto, Reiko Ohmori, Kazuo Kondo, Yukihiko Momiyama

{"title":"Associations between the Intakes of Plant Foods and Coronary Artery Disease in Japanese Patients Undergoing Coronary Angiography.","authors":"Emi Saita, Yoshimi Kishimoto, Reiko Ohmori, Kazuo Kondo, Yukihiko Momiyama","doi":"10.3177/jnsv.71.93","DOIUrl":"10.3177/jnsv.71.93","url":null,"abstract":"Several Japanese cohort studies have reported that the intakes of plant foods, such as vegetables, fruits, seaweed, and soy products, are inversely associated with coronary artery disease (CAD). However, the results of these studies have been inconsistent. We investigated the association between CAD and the intakes of plant foods in 802 Japanese patients undergoing coronary angiography. The intakes of vegetables, fruits, seaweed, and soy products were determined by 3 categories (<3, 3-4, and >4 times/wk). CAD was found in 511 patients, of whom 173 had myocardial infarction (MI). Patients with higher vegetable and fruit intakes had a significantly lower prevalence of CAD and tended to have a lower prevalence of MI. However, no significant difference was found in the prevalence of CAD or MI among the 3 groups of seaweed and soy product intakes. In the multivariate analyses, the prevalence of CAD decreased depending on the intakes of vegetables and fruits. The odds ratios (OR) for >4 times/wk intakes of vegetables and fruits relative to <3 times/wk were 0.46 (95%CI: 0.29-0.74) and 0.62 (0.40-0.95), respectively. Thus, in Japanese patients undergoing coronary angiography, the intakes of vegetables and fruits were found to be inversely associated with CAD but not with MI. However, no significant association was found between the intakes of seaweed or soy products and CAD or MI.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"93-99"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0