Journal of nutritional science and vitaminology最新文献

{"title":"Adding Lemon and n-3 PUFA-Rich Oil to Tomato Juice Preload to a Carbohydrate Meal Ameliorates Early Glycemic and Insulin Responses in Young Healthy Women: A Randomized Crossover Trial.","authors":"Yuki Higuchi, Shizuo Kajiyama, Kaoru Kitta, Takashi Miyawaki, Shinya Matsumoto, Neiko Ozasa, Shintaro Kajiyama, Yoshitaka Hashimoto, Michiaki Fukui, Saeko Imai","doi":"10.3177/jnsv.71.133","DOIUrl":"10.3177/jnsv.71.133","url":null,"abstract":"<p><p>The aim was to evaluate the acute effect of drinking tomato juice preloaded with lemon and perilla oil 10 min before consuming carbohydrate on postprandial blood glucose, insulin, and lipids concentrations in young healthy women. In this randomized controlled crossover study, 21 women (age 21.1±0.6 y, HbA1c 5.2±0.2%, mean±SD) consumed either 200 g of tomato juice, tomato juice with 10 g of lemon juice and 5 g of perilla oil (n-3 PUFA-rich oil), or water 10 min before consuming 200 g of boiled white rice for 3 separate days. The energy and fat in tomato juice with lemon/n-3 PUFA-rich oil were higher (energy 402 kcal, fat 5.6 g) than tomato juice (354 kcal, 0.6 g) and water (315 kcal, 0.6 g). The blood parameters were measured at 0, 30, 60, and 120 min after carbohydrate consumption and compared among 3 d. The plasma glucose at 30 min in tomato juice with lemon/n-3 PUFA-rich oil was significantly lower than that of water (103.1±3.4 mg/dL vs. 127.8±4.0 mg/dL, p<0.001, mean±SE) and tended to be lower than that of tomato juice (113.9±4.9 mg/dL, p=0.078). The serum insulin at 30 min was also significantly lower in tomato juice with lemon/n-3 PUFA-rich oil than that of tomato juice (p<0.01). Adding lemon and n-3 PUFA-rich oil to tomato juice before carbohydrate meal can be practical method to lower early postprandial glucose and insulin responses in young healthy women.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"133-139"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling Extended Alcohol Exposure in Mice Using a Solidified Lieber-DeCarli Diet with an Optimized Feeding Box.","authors":"Shuhei Morioka, Hazuki Ioroi, Sho Matsui, Yasuo Oguri, Satoshi Tsuzuki, Tsutomu Sasaki","doi":"10.3177/jnsv.71.474","DOIUrl":"https://doi.org/10.3177/jnsv.71.474","url":null,"abstract":"<p><p>Alcoholic liver disease (ALD) is a significant health issue globally, arising as a consequence of excessive alcohol consumption. Currently, there is no specific pharmacotherapy for ALD, and the most effective treatment options remain abstinence or reduced alcohol intake. The Lieber-DeCarli liquid diet (LDC) has long been used to model ALD and other alcohol-related disorders in rodents. However, challenges in managing LDC, such as difficulties with food intake measurement and maintaining nutritional balance, complicate its use. To overcome these limitations, we developed a novel protocol by converting the liquid LDC into a solid form using agar, creating the solidified LDC diet (SLD). This adaptation facilitates precise control of food intake for pair-feeding and prevents nutritional deficiencies. Mice can be fed SLD either with or without 5% (w/w) ethanol over several weeks, and the addition of an oral ethanol gavage on the final day induces fatty liver and liver injury, mirroring the characteristics of ALD. This approach offers several advantages over traditional LDC, including streamlined diet preparation, consistent intake, and improved control over pair-feeding, reducing the variability of ethanol effects across subjects. The new SLD protocol promotes a more reliable modeling of ALD, contributing to more reproducible results and aiding research into pharmacological interventions for ALD and alcohol-related disorders.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 5","pages":"474-485"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Egg Consumption and Coronary Artery Disease in Japanese Patients Undergoing Coronary Angiography.","authors":"Yoshimi Kishimoto, Emi Saita, Reiko Ohmori, Kazuo Kondo, Yukihiko Momiyama","doi":"10.3177/jnsv.71.435","DOIUrl":"10.3177/jnsv.71.435","url":null,"abstract":"<p><p>Many prospective studies of egg consumption and coronary artery disease (CAD) provided conflicting findings, and ethnicity may influence CAD risk. Two Japanese cohort studies, which were conducted around 1990, reported no significant association between egg consumption and CAD. However, there was no study showing the association between egg consumption and CAD in Japanese patients undergoing coronary angiography (CAG), whose intakes were assessed at the time of CAD diagnosis. The present study is a cross-sectional study to investigate egg intake and CAD in 795 Japanese patients undergoing CAG. Egg intake was classified into 3 categories (<3, 3-4 eggs/wk, and ≥1 egg/d). CAD was found in 506 patients, of whom 299 had multi-vessel disease (MVD). The prevalence of CAD or MVD did not differ markedly among 3 groups of <3, 3-4 eggs/wk, and ≥1 egg/d. Even after adjusting atherosclerotic risk factors and dietary intakes, multivariate analyses showed no significant associations between egg intake and CAD or MVD. Odds ratios (ORs) for 3-4 eggs/wk and ≥1 egg/d compared to <3 eggs/wk was 0.91 (95%CI: 0.62-1.34) and 1.06 (0.67-1.67) for CAD and 0.79 (0.55-1.15) and 1.22 (0.80-1.87) for MVD. However, only among 504 patients without lipid-lowering drugs, patients with 3-4 eggs/wk less often had MVD than those with <3 eggs/wk (p<0.05). In multivariate analyses, ORs for 3-4 eggs/wk and ≥1 egg/d compared to <3 eggs/wk were 0.56 (0.33-0.96) and 1.21 (0.69-2.13) for MVD. Thus, egg consumption was not associated with an increased risk at CAD in Japanese patients undergoing CAG.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 5","pages":"435-441"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maslinic Acid Supplementation Suppressed Early Onset Muscle Soreness and Systemic Fatigue after Full Marathon: A Randomized, Double-Blind, Placebo-Controlled Trial.","authors":"Katsuyuki Tokinoya, Takanaga Shirai, Kazuki Uemichi, Shusaku Murata, Yuki Yamauchi, Shotaro Murata, Tohru Takemasa","doi":"10.3177/jnsv.71.448","DOIUrl":"10.3177/jnsv.71.448","url":null,"abstract":"<p><p>Completing a full marathon not only causes muscle soreness and fatigue but also increases damage markers in the blood. Supplementary strategies can be used to reduce these effects. In a previous study, we focused on maslinic acid (MA), which reduces pain and suppresses inflammation. This study examined the effects of MA intake in full marathons. Twenty-seven healthy amateur runners (19 males and 8 females) were allocated to either the placebo (Pla) group or the MA group. Owing to one absence and variations in sample collection success, data from 22-26 participants were included in the final analyses depending on the outcome measure. Subjective muscle soreness and fatigue were assessed using a numerical rating scale (0-10), and blood samples were collected at three time points: before the race (Pre), immediately after the race (Post), and one day after (Day 1). Nonparametric statistical analyses revealed significant time effects for several blood markers; however, no group differences were observed at any time point. In contrast, subjective scores of muscle soreness at several sites and systemic fatigue did not differ between groups at Post but were significantly lower in the MA group than in the Pla group on Day 1 (p<0.017). These findings suggest that although MA supplementation during a full marathon does not attenuate immediate post-race physiological or subjective responses, it may facilitate the recovery process by reducing perceived muscle soreness and fatigue the following day.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 5","pages":"448-455"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal Absorption of L-Glucose via Sodium/Glucose Cotransporter 1 (Sglt1) in Rats.","authors":"Kunihiro Kishida, Yukiyasu Toyoda, Takamasa Tsuzuki","doi":"10.3177/jnsv.71.564","DOIUrl":"https://doi.org/10.3177/jnsv.71.564","url":null,"abstract":"<p><p>L-Glucose is an enantiomer of D-glucose. It is controversial whether intestinal absorption of L-glucose is mediated by sodium/glucose cotransporter 1 (Sglt1). We examined whether L-glucose is absorbed via Sglt1 using KGA-2727, an Sglt1-specific inhibitor, and via glucose transporter (Glut5), a fructose transporter, using fructose-fed rats as well. KGA-2727 significantly blocked the increase of plasma L-glucose levels and lowered the C_max and AUC_{0-180 min} values. Feeding the high-fructose diet induced significantly higher intestinal Glut5 mRNA expression and higher absorption of orally administered D-fructose, but did not affect L-glucose levels and pharmacokinetic parameters. The results suggest that L-glucose is likely transported via Sglt1 in rat small intestine.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 6","pages":"564-567"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Molecular Mechanisms and Treatment of Cancer-Related Cachexia.","authors":"Yongfei You, Yong Wang, Guohua Zhang, Yong Li","doi":"10.3177/jnsv.71.1","DOIUrl":"10.3177/jnsv.71.1","url":null,"abstract":"<p><p>Cancer cachexia is a multifactorial syndrome characterized by persistent skeletal muscle loss, with or without fat loss, which cannot be completely reversed by traditional nutritional support and leads to impaired organ function. Cachexia seriously reduces the quality of life of (QOL) patients, affects the therapeutic effect against cancers, increases the incidence of complications, and is an important cause of death for patients with advanced cancers. To date, no effective medical intervention has completely reversed cachexia, and no medication has been agreed upon. Here, we describe recent advances in the diagnosis, molecular mechanism and treatment of cancer-related cachexia.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"1-15"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of Screening Test for Inadequate Dietary Folate Intake Using Urinary Potassium Excretion as a Proxy Indicator in Young Adult Japanese Women.","authors":"Mami Sakuda, Ribeka Takachi, Tomoko Asai, Naoko Suga, Atsuko Kitano, Kumiko Saito, Kenji Toyama, Reiko Inai, Sachiko Maruya, Ai Tsuji, Rieko Nakata, Satoru Matsuda, Yasunori Ogura","doi":"10.3177/jnsv.71.442","DOIUrl":"10.3177/jnsv.71.442","url":null,"abstract":"<p><p>Although folate is essential for preconception care and reproductive health, non-invasive and valid methods for screening inadequate dietary folate intake are lacking. Urinary potassium excretion, a recovery biomarker of potassium intake, can be used as a proxy for dietary folate intake if the main sources of dietary folate and potassium are the same. This study examined the accuracy of screening using urinary potassium excretion as a proxy for inadequate dietary folate intake. Participants comprised 104 female university students who completed 3-d weighed food records (3dWFR) and 24-h urine collection on the third day of 3dWFR in April-July between 2019 and 2022. The major sources of dietary folate and potassium were identified, and the correlation coefficients between their intake and urinary potassium excretion were calculated. The area under the curve (AUC) and 95% confidence interval (CI) were calculated using receiver operating characteristic analysis. Vegetables were the food groups that contributed the most to dietary folate intake (42.7%) and potassium intake (28.9%). The correlation coefficient (r=0.57, p<0.001) between dietary folate intake based on the 3dWFR and potassium excretion was almost the same as that between potassium intake and excretion (r=0.63, p<0.001). Urinary potassium excretion could discriminate at ≥100-≥550 μg in 50 μg increments for insufficient dietary folate intake with >0.7 AUC value (and >0.5 lower limit of 95% CI). These findings indicate that urinary potassium excretion can be used as a proxy indicator to screen for individuals with inadequate dietary folate intake.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 5","pages":"442-447"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Regulation of Cholecystokinin Production by Synthetic and Natural Glucocorticoids in Enteroendocrine Cells.","authors":"Shingo Nakajima, Shoko Tsuchimine, Tohru Hira, Hiroshi Kunugi","doi":"10.3177/jnsv.71.411","DOIUrl":"https://doi.org/10.3177/jnsv.71.411","url":null,"abstract":"<p><p>Chronic stress often causes abnormal eating behavior and metabolism due at least in part to the activation of hypothalamic-pituitary-adrenal (HPA) axis resulting in increases glucocorticoids secretion. Cholecystokinin (CCK) is an anorexic gut hormone secreted from enteroendocrine I cells and controls digestion through the gastric emptying and digestive enzyme secretion. In the present study, we highlighted the function of glucocorticoids in CCK-producing cells with enteroendocrine model cell lines and male Wistar rats. We found that glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) are expressed in STC-1 cells known as an I cell model line. Synthetic (dexamethasone; DEX) and endogenous (corticosterone; CORT) glucocorticoids reduced CCK transcription in STC-1 cells. Depolarization-induced CCK secretion was attenuated by both glucocorticoids, whereas dietary peptide-induced CCK secretion was enhanced by acute CORT treatment. DEX and CORT treatments weakened phosphorylated signaling pathway for CCK transcription in an agonist-specific manner. Daily single injection of DEX but not CORT for 4 d decreased Cck mRNA in the upper small intestine with altered metabolism and gut glucocorticoid sensitivity in male Wistar rats. These findings provide a new insight to reveal stress-induced abnormal nutrient and metabolic status in relation to gastrointestinal dysfunctions.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 5","pages":"411-420"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Excessive Sucrose Intake on Aggressive Behavior and Peripheral Stress-Related Hormone and Catecholamines in BALB/c Mice during Adolescent Development.","authors":"Tohru Miyata, Eichi Nojima, Yuji Minai","doi":"10.3177/jnsv.71.16","DOIUrl":"10.3177/jnsv.71.16","url":null,"abstract":"<p><p>As binge eating and unbalanced diets increase the prevalence of obesity and metabolic disorders, it has been noted that the increase in psychiatric disorders is also a consequence of diet. The present study examined aggressive behavior and peripheral stress-related hormone and catecholamine levels in BALB/c mice fed a high-sucrose diet during adolescent development. BALB/c mice are rarely used in research assessing the effect of diet, but were used for ethnic and personal differences and as a new experimental model. BALB/c mice were fed a diet in which all carbohydrate components were replaced with sucrose for 4 wk and were subjected to the resident-intruder and social dominance tube test. Plasma insulin, corticosterone, and catecholamine levels were also compared to mice fed a control diet. The high-sucrose diet did not alter body weight, glucose tolerance, and plasma insulin levels in BALB/c mice, indicating that the diet was resilient to obesity. Mice fed a high-sucrose diet exhibited increased aggressive behaviors in the resident-intruder test and had a significantly higher win rate in the tube test. Increases in adrenal weight and plasma corticosterone as well as noradrenaline and adrenaline levels were exhibited in mice fed a high-sucrose diet. In particular, this is the first evidence of increased social dominance and hyperplasia of the adrenal glands by a sucrose diet. Sucrose diet intake increased aggression in mice and caused elevated peripheral hormones involving the HPA axis and the sympathetic nervous system, indicating that this may be a central nervous system-mediated effect of excess sucrose.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"16-24"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Compound Nutritional Supplement Relieving the Core Symptoms of Autism Rats.","authors":"Xinrong Pan, Yaoyao Xiu, Shiting Huang, Jinjie Lai, Xiaoxue Wang, Xinhui Cao, Liqun Jiang","doi":"10.3177/jnsv.71.34","DOIUrl":"10.3177/jnsv.71.34","url":null,"abstract":"<p><p>Autism, with a global morbidity of approximately 0.6% annually, significantly burdens on families and society. A predominant characteristic among autistic children is intestinal dysfunction, generating nutrient absorption issues. This often causes vitamin and mineral deficiencies, which significantly impacts neurological development. To address this, we have developed a comprehensive nutritional supplement containing compound vitamins, minerals, and gut bacteria. The aim of this study is to investigate the behavioral effects of this supplement on autism rats. The supplement formulated in this study encompasses compound vitamins, minerals, and intestinal bacteria. The autism offspring model (VPA model) was established through intraperitoneal injection of sodium valproate into pregnant rats. Behavioral assessments, gastrointestinal microbiota analysis, and brain development evaluations were conducted to assess the effects of the supplement on VPA offspring rats. A nutritional supplement enriched with vitamins (VB6, VB12, VC, VD, folic acid), minerals (calcium, magnesium), and bifidobacteria was prepared. Open field experiments demonstrated a 3-mo supplementation intervention effectively alleviated anxiety symptoms and enhanced curiosity levels in VPA offspring. The bead embedding experiment revealed the supplementation significantly improved stereotypical behaviors in VPA offspring. The nesting experiment showed a 3-mo supplementation intervention effectively enhanced cognitive abilities in VPA offspring rats. The three-box social experiment demonstrated the supplementation improved social novelty and tendency in VPA offspring. Analysis of gastrointestinal microbiota revealed the supplementation modulated the gut microbiome, promoting better nutrient absorption and overall health. Our findings suggest the comprehensive nutritional supplement, containing compound vitamins, minerals, and gut bacteria, effectively alleviates core symptoms of autism in rats. This study provides valuable insights into the potency of nutritional interventions in improving the quality of life for autistic individuals. Future research is warranted to further explore the mechanisms underlying these observed benefits and to assess the long-term effects of this supplement in larger clinical trials.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"34-45"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}