Journal of nutritional science and vitaminology最新文献_第6页

Fructo-Oligosaccharides Enhance the Expression of Genes Related to Focal Adhesion- and Inflammation-Pathways in Small Intestinal Absorptive Caco-2 Cells. 低聚果糖增强小肠吸收性Caco-2细胞局灶黏附和炎症通路相关基因的表达

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.481

Aya Harasawa, Shiori Ishiyama, Kazuki Mochizuki

{"title":"Fructo-Oligosaccharides Enhance the Expression of Genes Related to Focal Adhesion- and Inflammation-Pathways in Small Intestinal Absorptive Caco-2 Cells.","authors":"Aya Harasawa, Shiori Ishiyama, Kazuki Mochizuki","doi":"10.3177/jnsv.70.481","DOIUrl":"https://doi.org/10.3177/jnsv.70.481","url":null,"abstract":"Recently, we demonstrated, using mRNA microarray analysis, that fructo-oligosaccharides (FOS), which are indigestible carbohydrates, enhanced the expression of several inflammation-related genes, such as CLEC7A, CCL2, ITGA2, and F3, by ≥4-fold in Caco-2 cells, a model of human intestinal absorptive cells, independently of intestinal bacteria (Harasawa A et al., Nutrition, 112140, 2023). However, whether FOS enhances the expression of genes in other pathways, particularly the non-inflammatory pathways, in Caco-2 cells has not been investigated. Here, we explored the pathways affected by FOS, based on identification of differentially expressed genes with ≥2-fold change (linear-fold change) in expression upon FOS treatment. Caco-2 cells were cultured for 24 h in high glucose-Dulbecco's modified Eagle medium supplemented with 10% fetal calf serum containing FOS. The differentially expressed genes in these cells, identified using mRNA microarray analysis, were categorized using the pathway analysis and subsequently upregulated genes in typical pathways were subjected to protein network analysis. RT-qPCR was performed to validate the expression of selected genes. Treatment with 10% FOS enhanced the expression of a set of genes, such as ITGB8, ITGA6, SPP1, CAV1, LAMA3, ARHGAP5, and LAMC2, in the focal adhesion pathway. In addition, this treatment increased the expression of many genes involved in various inflammatory pathways, such as TNF, ITGA5, ITGB3, PTGS2, FGF2, FLNC, EDNRB, VEGFA, and MMP13. Protein network analysis showed that genes in the focal adhesion and endothelin pathways induced by FOS were closely associated with each other. FOS treatment of human intestinal absorptive-like cells enhances a set of genes in the focal adhesion and inflammation pathways.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 6","pages":"481-489"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant Vitamin Intake and LOX-Index in Japanese Municipal Workers. 日本市政工人的抗氧化维生素摄入量和 LOX 指数

IF 1.6 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.36

Mirai Sakanari, Masanori Ohta, Mayumi Nagano, Yoko Umeki, Akiko Nanri

{"title":"Antioxidant Vitamin Intake and LOX-Index in Japanese Municipal Workers.","authors":"Mirai Sakanari, Masanori Ohta, Mayumi Nagano, Yoko Umeki, Akiko Nanri","doi":"10.3177/jnsv.70.36","DOIUrl":"10.3177/jnsv.70.36","url":null,"abstract":"Antioxidant vitamin intake has been reported to be associated with decreased risk of cardiovascular diseases. To date, however, no study has examined the association between antioxidant vitamin intake and LOX-index, a predictive biomarker of cardiovascular disease. We investigated the cross-sectional association between antioxidant vitamin (α-carotene, β-carotene, α-tocopherol, and vitamin C) intake and LOX-index in Japanese municipal workers. Participants were 346 workers (171 men and 175 women aged 19-71 y) who received a health check-up and participated in a nutrition and health survey. Antioxidant vitamin intake was assessed using a validated brief self-administered diet history questionnaire. LOX-index was calculated by multiplying serum concentrations of the soluble form of lectin-like oxidized LDL receptor 1 by those of LOX-1 ligands containing apolipoprotein B. Multiple regression analysis was used to estimate the geometric mean of LOX-index according to tertile of each antioxidant vitamin intake. Overall, α-carotene, β-carotene, α-tocopherol, and vitamin C intake were not associated with LOX-index. However, in stratified analyses by sex, geometric means of LOX-index tended to decrease with antioxidant vitamin intake in women, but not in men. The geometric means of LOX-index for the lowest through highest tertile of α-carotene intake were 771 (604-984), 639 (511-799), and 564 (469-677) (p for trend=0.07). Our results suggest that there is no association between antioxidant vitamin intake and LOX-index in Japanese workers. The suggestive inverse association between antioxidant vitamin intake and LOX-index in women warrants further investigation.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 1","pages":"36-43"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of 1-Kestose on the Abundance of Inflammation-Related Gene mRNA in Adipose Tissue and the Gut Microbiota Composition in Rats Fed a High-Fat Diet. 1-Kestose 对高脂饮食大鼠脂肪组织中炎症相关基因 mRNA 丰度和肠道微生物群组成的影响

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.311

Kento Kuramitsu, Yoshihiro Kadota, Ayako Watanabe, Akihito Endo, Yoshiharu Shimomura, Yasuyuki Kitaura

{"title":"The Effects of 1-Kestose on the Abundance of Inflammation-Related Gene mRNA in Adipose Tissue and the Gut Microbiota Composition in Rats Fed a High-Fat Diet.","authors":"Kento Kuramitsu, Yoshihiro Kadota, Ayako Watanabe, Akihito Endo, Yoshiharu Shimomura, Yasuyuki Kitaura","doi":"10.3177/jnsv.70.311","DOIUrl":"https://doi.org/10.3177/jnsv.70.311","url":null,"abstract":"Chronic inflammation in adipose tissue is thought to contribute to insulin resistance, which involves the gut microbiota. Our previous studies have demonstrated that ingestion of 1-kestose can alter the gut microbiota composition, increase cecal butyrate levels, and improve insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Additionally, we found that 1-kestose supplementation ameliorated insulin resistance in obese rat models fed a high-fat diet (HFD), although the effects of 1-kestose on the abundance of inflammation-related gene in adipose tissue and gut microbiota composition in these rats were not explored. This study aimed to investigate the impact of 1-kestose on these parameters in HFD-fed rats, compared to OLETF rats. Male Sprague-Dawley rats were divided into two dietary groups, control or HFD, for 19 wk. Each group was further subdivided to receive either tap water or tap water supplemented with 2% (w/v) 1-kestose throughout the study. We evaluated gene expression in adipose tissue, as well as short-chain fatty acids (SCFAs) levels and microbial composition in the cecum contents. 1-Kestose intake restored the increased relative abundance of tumor necrosis factor (Tnf) mRNA in adipose tissue and the reduced level of butyrate in the cecum contents of HFD-fed rats to those observed in control diet-fed rats. Additionally, 1-kestose consumption changed the composition of the gut microbiota, increasing Butyricicoccus spp., decreasing UGC-005 and Streptococcus spp., in the cecum contents of HFD-fed rats. Our findings suggest that 1-kestose supplementation reduces adipose tissue inflammation and increases butyrate levels in the gut of HFD-fed rats, associated with changes in the gut microbiota composition, distinct from those seen in OLETF rats.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 4","pages":"311-317"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimal Body Weights for Adults with Severe Motor and Intellectual Disabilities. 严重运动障碍和智力障碍成人的最佳体重。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.248

Osamu Uemura, Yuki Oshio, Yuka Hasegawa, Hideaki Nakashima, Kiyomi Hattori, Yoshihiro Otobe

{"title":"Optimal Body Weights for Adults with Severe Motor and Intellectual Disabilities.","authors":"Osamu Uemura, Yuki Oshio, Yuka Hasegawa, Hideaki Nakashima, Kiyomi Hattori, Yoshihiro Otobe","doi":"10.3177/jnsv.70.248","DOIUrl":"https://doi.org/10.3177/jnsv.70.248","url":null,"abstract":"Determining the optimal body weight for individuals with severe motor and intellectual disabilities (SMID) lacks a standardized approach. In this study, we aimed to develop a formula to estimate the ideal body weight for each SMID patient, considering factors such as reduced muscle and bone mass. We analyzed data from 111 SMID patients (56 male, 55 female; age range 20 to 73 y) who underwent blood tests measuring creatinine (Cr) and cystatin C (cysC) for clinical reasons between Feb. 2018 and Feb. 2023. To create the optimal body weight formula, we utilized three variables: height, estimated glomerular filtration (eGFR)-Cr, and eGFR-cysC. The validity of the formula was assessed by comparing the measured triceps subcutaneous fat thickness (TSF) to the reference TSF (%TSF), evaluating how accurately it reflects the appropriate physique. The derived optimal body weight formula is as follows: Optimal body weight=(height)2×(18.5-25.0)×{1-0.41×(1-eGFR-cysC/eGFR-Cr)}×0.93. Our formula demonstrated validity when using %TSF as an indicator. Establishing a method to determine optimal body weight in SMID patients, considering their low muscle and bone mass, is crucial for accurate nutritional assessment and subsequent nutritional management.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 3","pages":"248-251"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Alaska Pollack Protein Ingestion on Neuromuscular Adaptation in Young Healthy Adults: A Randomized, Placebo-Controlled Trial. 摄入阿拉斯加鳕鱼蛋白质对健康年轻人神经肌肉适应性的影响：随机安慰剂对照试验。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.228

Tetsuya Hirono, Saeko Ueda, Eriko Yoshida, Kenji Uchida, Aleš Holobar, Yukiko Mita, Kohei Watanabe

{"title":"Effects of Alaska Pollack Protein Ingestion on Neuromuscular Adaptation in Young Healthy Adults: A Randomized, Placebo-Controlled Trial.","authors":"Tetsuya Hirono, Saeko Ueda, Eriko Yoshida, Kenji Uchida, Aleš Holobar, Yukiko Mita, Kohei Watanabe","doi":"10.3177/jnsv.70.228","DOIUrl":"10.3177/jnsv.70.228","url":null,"abstract":"Alaska pollack protein (APP), has been reported as a protein source that can enhance muscle hypertrophy more than other protein sources in animal studies. This study aimed to examine the effects of APP ingestion on muscle quantity and quality in young adults. Fifty-five young college students were assigned to two groups: APP and placebo (whey protein: WP) groups, and instructed to ingest 4.5 g of each protein in addition to daily meals, and to maintain their usual daily physical activities for 3 mo. Twenty-one and 23 students completed the intervention and were analyzed in APP and WP groups, respectively. The maximum knee extension torque significantly increased in both groups during the intervention. The motor unit discharge rate, which is an indicator of activation, for a given force level significantly decreased in both groups during the intervention, but its decrease in the APP group was significantly greater than in the WP group. Echo intensity of the vastus lateralis evaluated by ultrasound images significantly decreased in both groups. The muscle thickness and skeletal muscle mass did not change. Small amount of additional APP intake induces greater effects on neural activation than WP, suggesting the greater neural economy of generation of force.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 3","pages":"228-236"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional Imbalance between Omega-6 and Omega-3 Polyunsaturated Fatty Acids during Pregnancy Increases the Number of Pyramidal Neurons in the Basolateral Amygdala and Anxiety-Related Behavior in Offspring. 孕期奥米加 6 和奥米加 3 多不饱和脂肪酸之间的营养失衡会增加基底外侧杏仁核中锥体神经元的数量和后代的焦虑相关行为。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.411

Taro Kikuchi, Daigo Omokawa, Masanori Katakura, Miho Matsumata, Hidenori Aizawa, Makoto Sugita, Nobuyuki Sakayori

{"title":"Nutritional Imbalance between Omega-6 and Omega-3 Polyunsaturated Fatty Acids during Pregnancy Increases the Number of Pyramidal Neurons in the Basolateral Amygdala and Anxiety-Related Behavior in Offspring.","authors":"Taro Kikuchi, Daigo Omokawa, Masanori Katakura, Miho Matsumata, Hidenori Aizawa, Makoto Sugita, Nobuyuki Sakayori","doi":"10.3177/jnsv.70.411","DOIUrl":"https://doi.org/10.3177/jnsv.70.411","url":null,"abstract":"Modern agriculture allows for the production of foods that are high in n-6 linoleic acid and low in n-3 α-linolenic acid (LAhigh/ALAlow), which are suggested to be associated with an increased risk for the onset of anxiety disorders. However, there is not sufficient evidence to understand its underlying brain mechanism. Given that mouse offspring derived from mothers fed a LAhigh/ALAlow diet during gestation and early lactation showed increased anxiety-related behaviors and that rodents exposed to a LAhigh/ALAlow diet are more vulnerable to stress, in this study, we investigated the effects of maternal LAhigh/ALAlow diet consumption on stress-induced anxiety-related behavior and the brain structures involved in the expression of negative emotional states in mouse offspring. In a standard environment, offspring exposed to either the control diet or the LAhigh/ALAlow diet in utero showed similar stay times in the center zone in the open field test. On the other hand, under stressful environments, offspring exposed to the LAhigh/ALAlow diet in utero showed decreased stay times in the center zone compared to those exposed to the control diet. We further found that the number of a subpopulation of pyramidal neurons in the basolateral amygdala, which can regulate negative emotional behaviors, was greater in the offspring exposed to the LAhigh/ALAlow diet compared to those exposed to the control diet. These data suggest that maternal dietary imbalance between n-6 and n-3 polyunsaturated fatty acids confers stress vulnerability to offspring during the process of brain development.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 5","pages":"411-421"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paternal Zinc Deficiency and Its Transgenerational Effects on Zinc Transporters in Drosophila. 果蝇父系锌缺乏及其对锌转运蛋白的跨代影响。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.462

Kamaldeen Olalekan Sanusi, Murtala Bello Abubakar, Kasimu Ghandi Ibrahim, Mustapha Umar Imam

{"title":"Paternal Zinc Deficiency and Its Transgenerational Effects on Zinc Transporters in Drosophila.","authors":"Kamaldeen Olalekan Sanusi, Murtala Bello Abubakar, Kasimu Ghandi Ibrahim, Mustapha Umar Imam","doi":"10.3177/jnsv.70.462","DOIUrl":"https://doi.org/10.3177/jnsv.70.462","url":null,"abstract":"The nutritional status of fathers plays a significant role in influencing the growth, metabolism, and susceptibility to diseases in their offspring. Paternal zinc deficiency can lead to developmental programming effects on the offspring's zinc homeostasis. This study investigated the effects of paternal zinc deficiency on the zinc homeostasis of offspring in a Drosophila melanogaster (fruit fly) model. Male flies were reared on a diet supplemented with a zinc-chelator, N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN), from the egg stage until adulthood, and their offspring were subsequently reared on a normal diet for 7 d. Body zinc status and zinc transporters were assessed afterwards. The results indicated that the prenatal zinc deficiency significantly lowered total body zinc levels (p<0.05) compared to the controls. Additionally, the mRNA levels of zinc transporters, dZip42C.1, dZnT63C, and dZnT35C, were lower in the zinc-deficient male parents (p<0.05) and their male offspring (p<0.05). These findings suggested that paternal zinc deficiency can alter offspring zinc homeostasis, even when the offspring was fed a zinc-sufficient diet. This is an important finding, as zinc is an essential nutrient that is required for a variety of bodily functions. Further research is needed to better understand the mechanisms by which zinc deficiency in the male parent affects the health of the offspring and to develop strategies to prevent this from happening.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 6","pages":"462-469"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consumption of Fructooligosaccharides Influences the Action of Fecal MicroRNAs in Altering the Structure of Cultured Gut Microbiota in Mice. 食用果寡糖会影响粪便微RNA在改变小鼠培养肠道微生物群结构中的作用

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.387

Fumina Ohsaka, Moeka Yasui, Mayuko Yamaguchi, Kei Sonoyama

{"title":"Consumption of Fructooligosaccharides Influences the Action of Fecal MicroRNAs in Altering the Structure of Cultured Gut Microbiota in Mice.","authors":"Fumina Ohsaka, Moeka Yasui, Mayuko Yamaguchi, Kei Sonoyama","doi":"10.3177/jnsv.70.387","DOIUrl":"https://doi.org/10.3177/jnsv.70.387","url":null,"abstract":"Fecal microRNAs (miRNAs) derived from intestinal epithelial cells have been suggested to influence gut microbiota homeostasis. We recently showed that supplementing murine fecal small RNAs, most likely miRNAs, alters the structure of cultured fecal microbiota in a sequence-dependent manner. The present study investigated the effect of consuming fructooligosaccharides (FOS) on the action of fecal small RNAs in altering the structure of cultured fecal microbiota. Female C57BL/6J mice were allowed free access to AIN-93G diet, and tap water supplemented with or without 4% (w/v) FOS for 2 wk. As assessed by 16S rRNA gene sequence analysis in cecal contents, the gut microbiota structure differed between mice supplemented with and without FOS. Fecal bacteria isolated from the cecal contents of mice without FOS supplementation were cultured for 24 h under anaerobic conditions. The structure of cultured microbiota differed between the cultures supplemented with small RNAs isolated from the cecal contents of mice supplemented with and without FOS. Microarray analysis showed that the miRNA profile in the cecal contents differed between mice supplemented with and without FOS. We propose that FOS consumption influences the action of intestinal epithelial cell-derived miRNAs in altering the structure of cultured gut microbiota, and such FOS action is associated with changes in the profile of miRNAs. It may be possible that intestinal epithelial cell-derived miRNAs contribute, at least in part, to diet-induced alteration of gut microbiota.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 5","pages":"387-395"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Immature Soybeans on Lipid Metabolism in Rats Fed Normal and High-Fat High-Fructose NAFLD Diets. 未成熟大豆对正常膳食和高脂肪高果糖非酒精性脂肪肝膳食大鼠脂质代谢的影响

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.370

Takafumi Mizushige, Tomohiro Suzuki, Tadayoshi Utsuki, Yuna Ishikawa, Kirara Ogawa, Chinatsu Kanamaru, Sayo Shoji, Dai Nogimura, Haruna Aiso, Eriko Yoshida, Kenji Uchida, Yukihito Kabuyama

{"title":"Effects of Immature Soybeans on Lipid Metabolism in Rats Fed Normal and High-Fat High-Fructose NAFLD Diets.","authors":"Takafumi Mizushige, Tomohiro Suzuki, Tadayoshi Utsuki, Yuna Ishikawa, Kirara Ogawa, Chinatsu Kanamaru, Sayo Shoji, Dai Nogimura, Haruna Aiso, Eriko Yoshida, Kenji Uchida, Yukihito Kabuyama","doi":"10.3177/jnsv.70.370","DOIUrl":"https://doi.org/10.3177/jnsv.70.370","url":null,"abstract":"Edamame and chamame (brown edamame) are immature soybeans that contain abundant protein, vitamins, and dietary fiber. Edamame has a different nutrient composition compared with mature soybeans, as evidenced by its higher content of vitamins and folic acid. Recent studies have shown that proteins in mature soybeans, such as β-conglycinin, and dietary fiber influence the metabolism of lipids such as triglyceride and cholesterol. However, the effect of edamame on lipid metabolism has not been reported. In the present study, we investigated whether oral consumption of edamame or chamame affects lipid metabolism. We focused on the analysis of hepatic lipids, serum cholesterol, and fecal lipids in rats after feeding them a normal or non-alcoholic fatty liver disease (NAFLD) diet containing edamame or chamame for 6 wk. We found that the consumption of dietary edamame and chamame significantly lowered hepatic triglyceride and serum cholesterol levels compared with those in the control groups fed with normal and NAFLD diets. Intake of edamame and chamame improved the NAFLD-like fatty liver. Finally, intake of edamame and chamame resulted in a significantly higher amount of fecal lipids and bile acid than in the control, suggesting the stimulation of lipid excretion. Together, dietary edamame and chamame decrease hepatic and serum cholesterol by promoting lipid excretion, not by the regulation of hepatic gene expression, leading to the improvement of lipid metabolism in both normal and NAFLD model rats.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 5","pages":"370-379"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral Dysfunctions Caused by Pyridoxamine Deficiency in Drosophila melanogaster. 黑腹果蝇缺乏吡哆胺导致的行为障碍

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.252

Kohei Ueno, Izumi Nohara, Mitsuhiro Miyashita, Masanari Itokawa, Haruo Okado, Makoto Arai, Minoru Saitoe

引用次数: 0