Journal of nutritional science and vitaminology最新文献_第5页

Selective Eating Behavior and Delayed Bedtime in Children Aged 3-6 Years: The Mediating Role of Breakfast Tryptophan Intake. 3-6岁儿童选择性饮食行为与延迟就寝：早餐色氨酸摄入量的中介作用。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2026-01-01 DOI: 10.3177/jnsv.72.62

Naoki Sakane, Yaeko Kawaguchi, Junichiro Somei, Akiko Suganuma, Masayuki Domichi

{"title":"Selective Eating Behavior and Delayed Bedtime in Children Aged 3-6 Years: The Mediating Role of Breakfast Tryptophan Intake.","authors":"Naoki Sakane, Yaeko Kawaguchi, Junichiro Somei, Akiko Suganuma, Masayuki Domichi","doi":"10.3177/jnsv.72.62","DOIUrl":"10.3177/jnsv.72.62","url":null,"abstract":"Mealtime behaviors may influence sleep patterns in preschool children; however, this relationship remains unclear. This study aimed to clarify which mealtime behaviors affect sleep among preschool children. A total of 283 children aged 3-6 y were included in this study. Problematic mealtime behaviors-such as selective eating, clumsiness/manners, interest and concentration in eating, oral motor function, and overeating-were assessed. Data on wake-up time, bedtime, total sleep duration, and sleep midpoint were collected. The tryptophan index (Trp index) was calculated at breakfast. A mediation analysis, controlling for age in month and sex, was conducted under the assumption of a causal pathway from selective eating behavior to bedtime via the Trp index. The analysis estimated both direct and indirect effects. Compared to the non-selective eating behavior group (n=121), the selective eating behavior group (n=162) exhibited later wake-up times (6:44±0:28 vs. 6:52±0:32; p=0.043), later bedtimes (21:15±0:37 vs. 21:33±0:33; p<0.001), later midpoints of sleep (2:00±0:27 vs. 2:13±0:31; p<0.001), shorter total sleep (9.5±0.6 vs. 9.3±0.7 h; p=0.018), and a lower Trp-index (285±167 vs. 234±149; p=0.007). Selective eating behavior was associated with lower tryptophan intake at breakfast, which in turn was linked to later bedtimes. The mediation analysis showed that tryptophan intake partially mediated the relationship between selective eating behavior and sleep timing (proportion mediated=13.6%). These findings suggests that a significant association was observed between selective eating behavior and poor sleep habits, and tryptophan intake at breakfast partially mediated this association.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 1","pages":"62-69"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between the Timing of Seafood, EPA, DHA Consumption and Sleep Pattern: A Cross-Sectional Study. 食用海产品的时间、EPA、DHA的消耗和睡眠模式之间的关系：一项横断面研究。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2026-01-01 DOI: 10.3177/jnsv.72.272

Yun-Peng Lo, Eriko Yoshida, Kenji Uchida, Shigenobu Shibata, Yu Tahara

{"title":"Association between the Timing of Seafood, EPA, DHA Consumption and Sleep Pattern: A Cross-Sectional Study.","authors":"Yun-Peng Lo, Eriko Yoshida, Kenji Uchida, Shigenobu Shibata, Yu Tahara","doi":"10.3177/jnsv.72.272","DOIUrl":"https://doi.org/10.3177/jnsv.72.272","url":null,"abstract":"Seafood, which is rich in omega-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), is reported to be associated with sleep. Animal studies have suggested that these fatty acids influence circadian clock system. People can be classified into morning, intermediate, and evening types based on their chronotype. Social jetlag, defined as the discrepancy in sleep schedule between workdays and free days, is more pronounced in individuals with an evening chronotype. However, the association between the timing of seafood and EPA and or DHA consumption and sleep phase in humans remains unclear. This cross-sectional study aimed to examine the relationship between seafood, EPA, and DHA intake at three different mealtimes and from snacks and sleep patterns among Japanese adults. Dietary and sleep data were collected from 5,975 adults aged 18-75. Generalized estimating equations were used to assess the associations between sleep patterns and seafood, EPA, and DHA intake at breakfast, lunch, dinner, and snack times-measured using a mobile food-logging application-taking chronotype and social jetlag into consideration. Higher total daily intake of seafood, EPA, and DHA was associated with a morning chronotype and less social jetlag. Intake at breakfast and lunch related to morningness and less social jetlag, with breakfast showing the strongest association. These findings suggest that both the quantity and timing of seafood, EPA, and DHA intake may be related to sleep patterns; however, causal relationships cannot be inferred due to the cross-sectional design.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 4","pages":"272-283"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persimmon-Derived Tannins Ameliorated Cholesterol Levels in Liver Tissues Induced by a High-Fat Diet and Concurrently Increased the Diversity of the Gut Microbiota of Rats. 柿子衍生单宁改善高脂肪饮食诱导的肝组织胆固醇水平，同时增加肠道微生物群的多样性。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2026-01-01 DOI: 10.3177/jnsv.72.307

Naoko Mochida, Shin-Ichi Kayano, Masahiro Kitabatake, Toshihiro Ito, Yasunori Ogura, Hiroe Kikuzaki, Yoko Matsumura

{"title":"Persimmon-Derived Tannins Ameliorated Cholesterol Levels in Liver Tissues Induced by a High-Fat Diet and Concurrently Increased the Diversity of the Gut Microbiota of Rats.","authors":"Naoko Mochida, Shin-Ichi Kayano, Masahiro Kitabatake, Toshihiro Ito, Yasunori Ogura, Hiroe Kikuzaki, Yoko Matsumura","doi":"10.3177/jnsv.72.307","DOIUrl":"https://doi.org/10.3177/jnsv.72.307","url":null,"abstract":"A number of studies have suggested that tannins improve lipid metabolism disorders. Based on the close relationship between liver and the gut microbiota through the gut-liver axis, we hypothesized that tannins may reduce lipid accumulation in the liver by modulating the gut microbiota. To test this hypothesis, we administered persimmon-derived tannins to rats fed a high-fat diet for 11 wk. Blood parameters and cholesterol, TG, and lipid droplet areas in the liver tissues were measured, and the gut microbiota of the cecal contents was analyzed using 16S rDNA sequencing. The results showed that persimmon-derived tannins significantly suppressed high-fat diet-induced increases in hepatic cholesterol levels. We also observed significant changes in the gut microbiota, including increased α- and β-diversity, a decreased Bacillota/Bacteroidota ratio, and an increased relative abundance of 15 genera, including Akkermansia, Bacteroides, Alloprevotella, and Alistipes. Collectively, these results suggest that persimmon-derived tannins may reduce lipid accumulation in the liver tissues, at least in part, through modulating the gut microbiota, indicating their potential as a functional food component for the prevention of liver diseases. Moreover, these findings provide new insights into the role of plant-derived polyphenols in the regulation of lipid metabolism through gut microbiota modulation. This study is significant because it revealed a relationship between the functionality of persimmon-derived tannins and the gut microbiota.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"72 4","pages":"307-318"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Correlation of the Severity of Vascular Calcification with Calcium and Phosphorus Metabolism and Microinflammation in Malnourished Uremic Patients. 营养不良尿毒症患者血管钙化程度与钙磷代谢及微炎症的临床相关性

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.148

Li Zhang, ChenChen Li, Yan Gao, ZiWen Zhang, Lin Li, Jing Hu, Ling Tian

{"title":"Clinical Correlation of the Severity of Vascular Calcification with Calcium and Phosphorus Metabolism and Microinflammation in Malnourished Uremic Patients.","authors":"Li Zhang, ChenChen Li, Yan Gao, ZiWen Zhang, Lin Li, Jing Hu, Ling Tian","doi":"10.3177/jnsv.71.148","DOIUrl":"https://doi.org/10.3177/jnsv.71.148","url":null,"abstract":"The research assessed calcium (Ca) and phosphorus (P) metabolism and microinflammation in malnourished uremic patients, focusing on the severity of vascular calcification, and examined the relationship between Ca and P metabolism indicators and microinflammation and the severity of vascular calcification. Seventy-eight patients undergoing hemodialysis treatment for ≥6 mo were collected. General information and anthropometric and blood biochemical indices were recorded, including gender, age, body mass index, mid-arm muscle circumference, albumin, intact parathyroid hormone, and Ca and P product (Ca×P). The severity of vascular calcification was graded. The correlation between the severity of vascular calcification in patients and each of the clinical indicators was analyzed. The diagnostic value of Ca and P metabolism and microinflammatory factors for vascular calcification in malnourished uremic patients was assessed. All enrolled patients were divided into a non-vascular calcification group (n=42) and a vascular calcification group (n=36) according to coronary artery calcification (CAC) scoring, and the probability of vascular calcification was 46%. The dialysis duration, Ca×P, P, hypersensitive C-reactive protein (hs-CRP), and interleukin 6 (IL-6) levels were significantly higher in the vascular calcification group than in the non-vascular calcification group. hs-CRP, IL-6, Ca×P, and P had predictive potency for vascular calcification in patients. CAC scores were correlated positively with hs-CRP, IL-6, Ca×P, and P. Malnourished uremic patients have a higher incidence of vascular calcification. hs-CRP, IL-6, Ca×P, and P are all independent risk factors for vascular calcification in uremic patients, and are positively correlated with the severity of vascular calcification.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"148-154"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Dietary Menthol on Autonomic Thermoregulation in a Cold Environment. 饲粮薄荷醇对低温环境下自主体温调节的影响。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.173

Noriyuki Mori, Masumi Takano, Aya Nakashima, Eriko Inoue, Miki Yanai, Nanako Kondo, Asaka Maikuma

{"title":"Effects of Dietary Menthol on Autonomic Thermoregulation in a Cold Environment.","authors":"Noriyuki Mori, Masumi Takano, Aya Nakashima, Eriko Inoue, Miki Yanai, Nanako Kondo, Asaka Maikuma","doi":"10.3177/jnsv.71.173","DOIUrl":"https://doi.org/10.3177/jnsv.71.173","url":null,"abstract":"Human body temperature homeostasis is regulated by both behavioral and autonomic thermoregulation. The transient receptor potential melastatin 8 (TRPM8) channel, a cold receptor, plays a critical role in cold perception and thermoregulation. Menthol, which activates TRPM8, has been shown to promote the \"browning\" of white adipocytes, enhancing thermogenesis. However, its effect on autonomic thermoregulation has remained unclear. To address this, the present study examines the influence of dietary menthol intake on autonomic thermoregulation in mice, with a focus on body temperature regulation under cold conditions. In this experiment, mice were fed diets containing 0.25% and 0.5% menthol for either 2 or 4 wk. The results indicated that the 0.5% menthol diet significantly reduced food intake, body weight, and visceral fat. In contrast, the 0.25% menthol diet showed no significant impact on these factors. Notably, mice treated with the 0.25% menthol diet for 4 wk suppressed the decrease in rectal and interscapular brown adipose tissue (IBAT) temperatures in a cold environment under anesthesia. Additionally, TRPM8 gene expression in IBAT was upregulated after 4 wk of 0.25% menthol diet consumption. These findings suggest that dietary menthol, especially at low concentrations, improves autonomic thermoregulation by activating TRPM8 without significantly affecting food intake or body weight.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"173-179"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium, Vitamin D, and Dairy Intake and Premenstrual Syndrome: A Cross-Sectional Study. 钙、维生素D和乳制品摄入与经前综合症：一项横断面研究。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.155

Akiko Nanri, Mirai Sakanari, Haruka Mantani, Anri Hirabayashi, Momoka Furuse, Natsuki Yokote, Michi Nakamura, Takashi Takeda, Masanori Ohta

{"title":"Calcium, Vitamin D, and Dairy Intake and Premenstrual Syndrome: A Cross-Sectional Study.","authors":"Akiko Nanri, Mirai Sakanari, Haruka Mantani, Anri Hirabayashi, Momoka Furuse, Natsuki Yokote, Michi Nakamura, Takashi Takeda, Masanori Ohta","doi":"10.3177/jnsv.71.155","DOIUrl":"https://doi.org/10.3177/jnsv.71.155","url":null,"abstract":"Calcium and vitamin D have been suggested to be associated with the amelioration of symptoms of premenstrual syndrome (PMS). However, evidence for an association between the dietary intake of these nutrients and PMS is limited and inconsistent. We examined the cross-sectional association of calcium and vitamin D intake with PMS. Participants were 390 women aged 22-49 y who responded to a mail survey in 2022-2023. Dietary intake was assessed using a validated self-administered diet history questionnaire. PMS were assessed using the Premenstrual Symptoms Questionnaire. Logistic regression analysis was used to estimate odds ratios of PMS according to tertiles of calcium and vitamin D intake with adjustment for potential confounding variables. The prevalence of moderate to severe PMS was 10% (39 women). Neither calcium nor vitamin D intake was significantly associated with PMS. However, calcium intake was associated with a decreased prevalence of PMS, albeit without statistical significance, with multivariable-adjusted odds ratios (95% CI) for PMS in the lowest through highest tertiles of calcium intake of 1.00 (reference), 0.47 (0.18-1.25), and 0.27 (0.07-1.08), respectively (p for trend=0.06). The odds ratio of PMS was low in the highest tertile of vitamin D intake compared with the lowest, but without statistical significance (odds ratio 0.56, 95% CI 0.19-1.66). Our findings suggest that calcium and vitamin D intake was not appreciably associated with PMS. The suggestive inverse association between calcium intake and PMS requires further investigation.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"155-162"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The J-Curve Relationship between Free Carnitine Levels and Cardiovascular Events in Patients with Heart Failure. 心力衰竭患者游离肉碱水平与心血管事件的j曲线关系

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.140

Shingo Watanabe, Junichi Onuma, Michio Usui

{"title":"The J-Curve Relationship between Free Carnitine Levels and Cardiovascular Events in Patients with Heart Failure.","authors":"Shingo Watanabe, Junichi Onuma, Michio Usui","doi":"10.3177/jnsv.71.140","DOIUrl":"https://doi.org/10.3177/jnsv.71.140","url":null,"abstract":"Hypocarnitinemia is thought to exacerbate heart failure by impairing mitochondrial function and increasing oxidative stress. While some studies suggest that elevated acylcarnitine levels are linked to cardiovascular events, limited data are available on the relationship between free carnitine levels and clinical outcomes in heart failure patients. This study aimed to investigate the association between free carnitine levels and clinical outcomes in patients hospitalized for heart failure. This retrospective study included 271 consecutive patients admitted to our hospital for their first episode of acute heart failure. Patients were divided into four quartiles based on free carnitine levels (quartile 1: <37.0 μmol/L, n=69; quartile 2: 37.0-49.7 μmol/L, n=68; quartile 3: 49.7-58.9 μmol/L, n=67; quartile 4: ≥58.9 μmol/L, n=67). The primary endpoints were 1-y cardiac mortality, rehospitalization due to heart failure, and its composite endpoint. The incidence of cardiovascular events was compared among the quartiles. Creatinine levels were significantly higher in quartile 4 than in other groups. There were no significant differences in age or BNP among the four groups. Additionally, the 1-y mortality rate was significantly higher in both quartile 1 and quartile 4, while the rehospitalization rate for heart failure within 1 y post-discharge was significantly higher in quartile 4. In summary, the relationship between free carnitine levels and mortality in heart failure patients showed a J-curve pattern, with both low and high levels associated with worse outcomes. Thus, extreme free carnitine levels may serve as potential risk factors for adverse clinical outcomes in this population.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"140-147"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the Effects of Short-Term Pterostilbene Intake on Healthy Participants: A Pilot Study. 短期摄入紫檀芪对健康参与者的影响分析：一项初步研究。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.70

Kurataka Otsuka, Daisuke Kuriki, Keiko Kamachi, Akira Tanaka, Ryosuke Matsuoka

{"title":"Analysis of the Effects of Short-Term Pterostilbene Intake on Healthy Participants: A Pilot Study.","authors":"Kurataka Otsuka, Daisuke Kuriki, Keiko Kamachi, Akira Tanaka, Ryosuke Matsuoka","doi":"10.3177/jnsv.71.70","DOIUrl":"10.3177/jnsv.71.70","url":null,"abstract":"Pterostilbene, a polyphenolic compound and an analog of resveratrol, exerts various biological activities and has higher bioavailability and metabolic stability than resveratrol. However, the effectiveness of pterostilbene intake in humans, particularly its effect on blood microRNA (miRNA) expression levels, has not been evaluated. Accordingly, this pilot study aimed to investigate the effects of pterostilbene on blood biochemistry and blood miRNA expression levels and the safety of continuous intake at doses of 10 or 100 mg/d over 12 wk. A double-blind, placebo-controlled parallel-arm comparison trial was conducted with 30 healthy men. In the analysis of blood miRNA expression levels, miR-34a and miR-193b showed very high increases at week 4 and after week 4 of intake, respectively, suggesting that the responders might be present among participants in the pterostilbene intake group. No adverse events were reported during the trial in any participant, and no abnormalities were observed upon examination by the responsible physician. Thus, pterostilbene intake would regulate blood miRNA expression levels, and the results can be utilized in human studies investigating miRNA expression levels with functional food ingredients.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"70-80"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Effects of Short- and Long-Chain Fructans: A Novel Strategy for Mitigating Ovalbumin Allergy via Microbiome-Driven Acetate Production. 短链和长链果聚糖的协同作用：通过微生物驱动的醋酸生产减轻卵清蛋白过敏的新策略。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.238

Hideaki Takahashi, Tadashi Fujii, Chikako Yamada, Kotoyo Fujiki, Nobuhiro Kondo, Kento Kuramitsu, Kohei Funasaka, Eizaburo Ohno, Yoshiki Hirooka, Takumi Tochio

{"title":"Synergistic Effects of Short- and Long-Chain Fructans: A Novel Strategy for Mitigating Ovalbumin Allergy via Microbiome-Driven Acetate Production.","authors":"Hideaki Takahashi, Tadashi Fujii, Chikako Yamada, Kotoyo Fujiki, Nobuhiro Kondo, Kento Kuramitsu, Kohei Funasaka, Eizaburo Ohno, Yoshiki Hirooka, Takumi Tochio","doi":"10.3177/jnsv.71.238","DOIUrl":"https://doi.org/10.3177/jnsv.71.238","url":null,"abstract":"The gut microbiota has been implicated in the modulation of food allergies. Building on previous studies on the preventive effects of combining short-chain fructan 1-kestose (Kes) and long-chain fructan inulin (Inu) in food allergies, we investigated their therapeutic effects in an ovalbumin (OVA)-induced food allergy mouse model. Following OVA sensitization, the mice received 5% Kes and Inu, either individually or a combined 2.5% dose of each, for 4 wk. We assessed allergy-related markers, such as OVA-specific serum IgE (OVA-sIgE) levels, in the blood and monitored changes in the gut microbiome. The intake of fructans ameliorated allergic symptoms and stabilized rectal temperatures, with a significant reduction in OVA-sIgE levels only in the combined Kes and Inu group (Kes+Inu), p<0.05. Gut microbiota diversity analysis revealed significant differences in beta diversity between the groups not receiving fructans and those receiving Kes, Inu, or Kes+Inu (p<0.01 each). Specifically, in the Kes+Inu group, the abundance of the genus UBA7173 belonging to the family Muribaculaceae significantly increased. Additionally, acetate levels were significantly elevated only in the Kes+Inu group and correlated positively with the presence of the genus UBA7173. These findings indicated that the combined intake of Kes and Inu improves allergic outcomes, positively affects the gut microbiome, and enhances the production of acetate.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 3","pages":"238-247"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Cannabidiol Bioavailability: Development and Evaluation of an Amorphous Cannabidiol Powder Formulation. 提高大麻二酚的生物利用度：无定形大麻二酚粉末制剂的开发与评价。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.312

Hiroki Aoyama, Tatsuya Ogawa, Hitomi Ozawa-Umeta, Koji Teshima, Tadashi Hashimoto, Teruyuki Sudo, Kazuki Hashimoto, Takanori Tsuda

{"title":"Enhancing Cannabidiol Bioavailability: Development and Evaluation of an Amorphous Cannabidiol Powder Formulation.","authors":"Hiroki Aoyama, Tatsuya Ogawa, Hitomi Ozawa-Umeta, Koji Teshima, Tadashi Hashimoto, Teruyuki Sudo, Kazuki Hashimoto, Takanori Tsuda","doi":"10.3177/jnsv.71.312","DOIUrl":"https://doi.org/10.3177/jnsv.71.312","url":null,"abstract":"Despite the various beneficial properties of cannabidiol (CBD), such as antioxidant, anti-inflammatory, analgesic, antidepressant, and anxiolytic activities, its clinical utility is limited due to its notably low bioavailability (BA). To address this issue, we developed an amorphous CBD powder formulation using solvent shift method, which only uses materials approved for food-grade applications. In a pharmacokinetic study in male Sprague-Dawley rats, we orally administered 10 mg/kg of CBD isolate powder with a crystalline structure and our developed amorphous CBD powder formulation. The Cmax values demonstrated a 3.9-fold increase for the amorphous CBD powder formulation containing polyvinylpyrrolidone (PVP) as a polymer (F3) and a 3.0-fold increase for the amorphous CBD powder formulation containing hydroxypropyl methylcellulose (HPMC) as a polymer (F4) compared to the CBD isolate powder. Furthermore, the AUC0-6h values for F3 and F4 were 5.3- and 5.2-fold higher than those for CBD isolate powder, respectively, indicating a significant enhancement. The Tmax values were also significantly shorter for F3 and F4, at 0.9±0.1 h and 0.8±0.1 h, respectively, compared to >6.0 h for CBD isolate powder. These findings demonstrate the superior BA of the amorphous CBD formulation. Based on these results, the amorphous CBD formulation is expected to be a highly absorbable CBD formulation, thereby advancing its use in food and supplements.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 4","pages":"312-320"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0