Journal of nutritional science and vitaminology最新文献_第5页

Effect of Mixed Solid Food and Water Intake on Blood Glucose Level and Energy Metabolism. 固体食物和水混合摄入对血糖水平和能量代谢的影响。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.490

Takuro Tobina, Kaori Nakamine, Shouhei Takeuchi, Rie Tomiga-Takae, Katsuhisa Omagari, Tomoki Yamashita

{"title":"Effect of Mixed Solid Food and Water Intake on Blood Glucose Level and Energy Metabolism.","authors":"Takuro Tobina, Kaori Nakamine, Shouhei Takeuchi, Rie Tomiga-Takae, Katsuhisa Omagari, Tomoki Yamashita","doi":"10.3177/jnsv.70.490","DOIUrl":"https://doi.org/10.3177/jnsv.70.490","url":null,"abstract":"Carbohydrate-rich solid foods, such as bread, pasta, and steamed rice, are applied for test meals in studies examining digestion and absorption of food related to glucose metabolism and sports science. Such research must consider that drinking water is sometimes better as it avoids the risk of choking or aspiration. However, the water increases test meal volume and dilutes glucose concentration, which may influence the digestion and absorption of ingested foods, as well as energy metabolism. Therefore, this study aimed to investigate whether the peak time and concentration of glucose and energy metabolism will differ among the intake of steamed rice alone (Rice), simultaneous intake of steamed rice and water (Mixed), and water alone (Water). Following the intake of the test meals, there was an immediate increase in blood glucose in Mixed compared to Rice and Water. The glucose peak time of Rice (60 (56-68) min; median and quartile) was also delayed compared to Mixed (38 (29-45) min). The blood lactate peak time was also significantly different in Mixed and Rice. Although meal and time interaction was not found in energy expenditure, Mixed increases the respiratory quotient by 40 min compared to Water. In conclusion, this study demonstrated that simultaneous intake of steamed rice and water hasted digestion and absorption of glucose and activates glycolysis. Future studies investigating gastric emptying rate and glucose metabolism should ensure that the conditions of fluid intake and the test meal volumes are consistent and do not differ significantly.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 6","pages":"490-495"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic Oral Intake of Soy Peptide Alleviates Anhedonia in Normally Housed Male C57BL/6J Mice. 长期口服大豆肽可缓解正常饲养的雄性 C57BL/6J 小鼠的失神症状。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.430

Miku Hamasaki, Chihiro Yano, Koki Zeze, Kengo Kuroki, Nana Nishikawa, Hiroaki Kozaki, Shigeki Furuya

引用次数: 0

Summer Nutritional Status and Appetite Are Associated with the Frequency of Hot Meal/Drink Intake among Japanese Older People. 日本老年人的夏季营养状况和食欲与热餐/热饮摄入频率有关。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.288

Kyoko Fujihira, Masaki Takahashi, Ai Iizuka, Hiroyuki Suzuki, Naoyuki Hayashi

{"title":"Summer Nutritional Status and Appetite Are Associated with the Frequency of Hot Meal/Drink Intake among Japanese Older People.","authors":"Kyoko Fujihira, Masaki Takahashi, Ai Iizuka, Hiroyuki Suzuki, Naoyuki Hayashi","doi":"10.3177/jnsv.70.288","DOIUrl":"https://doi.org/10.3177/jnsv.70.288","url":null,"abstract":"This study examined the relationship between the frequency of consuming cold or hot meal/drink during summer and the nutritional status, appetite, and energy intake among Japanese older people. The cross-sectional study was conducted in August 2021, targeting 60 adults aged 65 y and older. The Mini Nutritional Assessment (MNA) was used for nutritional status evaluation, the Simplified Nutritional Appetite Questionnaire (SNAQ) for appetite scoring, and food frequency questionnaire to assess energy intake. Participants reported on the frequency of consuming cold or hot meal/drink during the summer. Those who reported consuming hot meals \"moderate\" (p=0.033) or \"frequent\" (p=0.005) during summer had a higher BMI than those who reported minimal consumption. Participants who reported \"frequent\" consumption of hot meals in summer had higher MNA scores than those who reported \"minimal\" consumption (p=0.014). Participants who reported a \"frequent\" consumption of hot meals had higher SNAQ scores compared to those who reported \"minimal\" (p<0.001) or \"moderate\" (p=0.001). Similarly, participants who reported a \"frequent\" consumption of hot drinks had higher SNAQ scores than those reporting \"minimal\" (p=0.021) or \"moderate\" (p=0.008). The nutritional status and appetite during summer in Japanese older people were associated with the frequency of consuming hot meals and drinks.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 3","pages":"288-292"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Oleuropein on Anti-Obesity and Uncoupling Protein 1 Level in Brown Adipose Tissue in Mild Treadmill Walking Rats with Diet-Induced Obesity. 油菜素对轻度跑步机行走肥胖大鼠抗肥胖和棕色脂肪组织中解偶联蛋白1水平的影响

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.193

Yuriko Oi-Kano, Tsuyoshi Goto, Haruya Takahashi, Yusaku Iwasaki, Teruo Kawada

{"title":"Effect of Oleuropein on Anti-Obesity and Uncoupling Protein 1 Level in Brown Adipose Tissue in Mild Treadmill Walking Rats with Diet-Induced Obesity.","authors":"Yuriko Oi-Kano, Tsuyoshi Goto, Haruya Takahashi, Yusaku Iwasaki, Teruo Kawada","doi":"10.3177/jnsv.70.193","DOIUrl":"10.3177/jnsv.70.193","url":null,"abstract":"Oleuropein aglycone (OA), which is the absorbed form of oleuropein, is a major phenolic compound in extra virgin olive oil. We analyzed the anti-obesity effect of OA intake combined with mild treadmill walking (MTW, 4 m/min for 20 min/d, 5-6 d/wk, without electric shocks and slope) in rats under a high-fat diet (HF). Four-week-old male Sprague-Dawley rats (n=28) were equally divided into four groups: control (HF), 0.08% oleuropein-supplemented HF (HFO), HF with MTW (HF+W), and HFO with MTW (HFO+W) groups. After 28 d, the inguinal subcutaneous fat content and weight gain were significantly lower in the HFO+W group than in the control group. The HFO+W group also had significantly higher levels of urinary noradrenaline secretion, interscapular brown adipose tissue, uncoupling protein 1, brain transient receptor potential ankyrin subtype 1 (TRPA1), vanilloid subtype 1 (TRPV1), and brain-derived neurotrophic factor (BDNF) than the control group. Especially, the HFO+W group showed a synergistic effect on noradrenaline secretion. Therefore, OA combined with MTW may accelerate the enhancement of UCP1 and BDNF levels in rats with HF-induced obesity by increasing noradrenaline secretion after TRPA1 and TRPV1 activation.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 3","pages":"193-202"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Muscle-Protective Effect of Carnosine against Dexamethasone-Induced Muscle Atrophy in C2C12 Myotube. 肉碱对地塞米松诱导的 C2C12 肌管肌肉萎缩的保护作用

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.219

Md Mizanur Rahman, Anayt Ulla, Hiroki Moriwaki, Yusuke Yasukawa, Takayuki Uchida, Takeshi Nikawa

{"title":"Muscle-Protective Effect of Carnosine against Dexamethasone-Induced Muscle Atrophy in C2C12 Myotube.","authors":"Md Mizanur Rahman, Anayt Ulla, Hiroki Moriwaki, Yusuke Yasukawa, Takayuki Uchida, Takeshi Nikawa","doi":"10.3177/jnsv.70.219","DOIUrl":"https://doi.org/10.3177/jnsv.70.219","url":null,"abstract":"This study investigated the protective effect of carnosine and its components (L-histidine and β-alanine [HA]) against dexamethasone (Dex)-induced muscle atrophy in C2C12 myotubes. Myotubes were treated with Dex (10 μM) to induce muscle atrophy manifested by decreased myotube diameter, low myosin heavy chain content, and increased expression of muscle atrophy-associated ubiquitin ligases (Atrogin-1, MuRF-1, and Cbl-b). Carnosine (20 mM) treatment significantly improved the myotube diameter and MyHC protein expression level in Dex-treated C2C12 myotubes. It also downregulated the expression of Atrogin-1, MuRF-1, and Cbl-b and suppressed the expression of forkhead box O3 (FoxO3a) mediated by Dex. Furthermore, reactive oxygen species production was increased by Dex but was ameliorated by carnosine treatment. However, HA (20 mM), the component of carnosine, treatment was found ineffective in preventing Dex-induced protein damage. Therefore, based on above results it can be suggested that carnosine could be a potential therapeutic agent to prevent Dex-induced muscle atrophy compared to its components HA.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 3","pages":"219-227"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Japanese Diet on Post-Exercise Glycogen Recovery in Mice Skeletal Muscle and Liver. 日本饮食对小鼠运动后骨骼肌和肝脏糖原恢复的影响。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.470

Atsuko Koike, Takuya Karasawa, Shin Terada

{"title":"Effects of Japanese Diet on Post-Exercise Glycogen Recovery in Mice Skeletal Muscle and Liver.","authors":"Atsuko Koike, Takuya Karasawa, Shin Terada","doi":"10.3177/jnsv.70.470","DOIUrl":"https://doi.org/10.3177/jnsv.70.470","url":null,"abstract":"The diet consumed by most Japanese people, which contains high amounts of carbohydrate and low levels of fat compared with the Western-style diet (WD), has been considered an effective diet for promoting glycogen recovery after exercise. However, there is no direct evidence to support this general belief, because no studies have examined the effect of whole, actually cooked Japanese-style diet (JD) on post-exercise glycogen replenishment. In this study, we comparatively examined the effects of a cooked typical JD and WD on glycogen accumulation in mouse skeletal muscle and liver after acute exercise. One-week menus (total 21 meals) of the JD and WD were reproduced based on national nutrition surveys in Japan and the U.S. All the meals were cooked, mixed and then fed to mice after acute 60-min running exercise. After the 4-h recovery period, mice given the JD had significantly higher muscle and liver glycogen concentrations than those fed the isoenergetic WD. Furthermore, even after the 24-h recovery period, the JD-fed mice also had significantly higher muscle glycogen concentration than the isoenergetic WD-fed group. Compared with the mice fed a WD, the JD-fed mice showed significantly higher plasma insulin level during the 4-h but not the 24-h recovery period. These results suggest that both short- and long-term feeding of the JD promote post-exercise muscle glycogen recovery compared to the WD, possibly through an insulin-dependent mechanism and non-insulin-dependent mechanism, respectively.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 6","pages":"470-480"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Disaster Knowledge Level and the First Step of Stockpiling Food for a Disaster. 灾害知识水平与为灾害储备食物的第一步之间的关系。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.422

Moeka Harada, Nobuyo Tsuboyama-Kasaoka, Jun Oka, Rie Kobayashi

{"title":"Association between Disaster Knowledge Level and the First Step of Stockpiling Food for a Disaster.","authors":"Moeka Harada, Nobuyo Tsuboyama-Kasaoka, Jun Oka, Rie Kobayashi","doi":"10.3177/jnsv.70.422","DOIUrl":"https://doi.org/10.3177/jnsv.70.422","url":null,"abstract":"This study clarifies the association between disaster knowledge levels and beginning to stockpile food at home as a disaster preparedness. This survey was conducted between 18-20 December 2019 using a self-administered web-based questionnaire. The participants were recruited from panel members of an online survey company. A total of 1,200 adults living in the five Japanese prefectures with the highest predicted food shortages after the anticipated Nankai Trough earthquake, took part in the study. Multivariable logistic regression analyses revealed a significant positive relationship between disaster knowledge level and beginning food stockpiling (p for trend <0.001). Compared with those who had a low level of disaster knowledge, participants who had a medium level of knowledge were 2.11 times more likely to begin stockpiling food (adjusted odds ratio [OR]: 2.11, 95% confidence intervals [CI]: 1.49-2.97), whereas those with the highest knowledge level were 2.52 times more likely to begin stockpiling food (adjusted OR: 2.52, 95% CI: 1.79-3.56). Beginning food stockpiling can be the first step toward disaster preparedness. It is considered that people with low disaster knowledge levels are more likely to have no beginning food stockpiling and are at high risk for disasters. These findings suggest ways to approach prioritizing people facing high disaster risk.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 5","pages":"422-429"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Individualized Nutritional Management Using Dishcook Improves Nutrition Status Markers in Patients with Intellectual Disability. 使用 Dishcook 进行个性化营养管理可改善智障患者的营养状况指标。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.352

Yuki Niida, Hidenori Onishi, Hirohiko Ohama, Hiromasa Tsubouchi, Akemi Koujimoto, Yasutaka Mizukami, Tomoko Okamoto, Masamichi Ikawa, Masafumi Kubota, Mayu Takebe, Naoko Takaku, Kino Tsuji, Chizu Kawahara, Taisei Inoue, Daiki Hasegawa, Yoshihiro Nakamori, Takeshi Hirobe, Osamu Yamamura

{"title":"Individualized Nutritional Management Using Dishcook Improves Nutrition Status Markers in Patients with Intellectual Disability.","authors":"Yuki Niida, Hidenori Onishi, Hirohiko Ohama, Hiromasa Tsubouchi, Akemi Koujimoto, Yasutaka Mizukami, Tomoko Okamoto, Masamichi Ikawa, Masafumi Kubota, Mayu Takebe, Naoko Takaku, Kino Tsuji, Chizu Kawahara, Taisei Inoue, Daiki Hasegawa, Yoshihiro Nakamori, Takeshi Hirobe, Osamu Yamamura","doi":"10.3177/jnsv.70.352","DOIUrl":"https://doi.org/10.3177/jnsv.70.352","url":null,"abstract":"Dishcook is a new cooking system that allows individual cooking using a dedicated induction heater. This study investigated whether Dishcook use affects the nutritional value of individuals with intellectual disabilities. This study was conducted on users receiving support from a continuous-employment office in Obama City, Fukui Prefecture, in 2022. Of these participants, 18 (seven women and 11 men) who requested the use of the Dishcook were included in the analysis. The study period was from January to August 2023. The mean age was 48.72±16.24 y. A significant increase in the overall phase angles of the limbs was observed. Triglyceride, LDL cholesterol, HbA1c, and serum zinc levels improved in patients who used the Dishcook. The phase angle obtained using Bioelectrical Impedance Analysis also improved, indicating the usefulness of the Dishcook in treating metabolic diseases and the possibility of individualized nutritional management.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 4","pages":"352-358"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Short-Term Zinc-Deficient Diet Maintains Serum Calcium Concentrations through Ca Absorption-Related Gene Expression in Rats. 短期缺锌饮食通过大鼠与钙吸收相关的基因表达维持血清钙浓度

IF 1.6 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.82

Takako Suzuki, Kazuharu Suzuki, Jun Takahashi, Yukio Nakamura

{"title":"A Short-Term Zinc-Deficient Diet Maintains Serum Calcium Concentrations through Ca Absorption-Related Gene Expression in Rats.","authors":"Takako Suzuki, Kazuharu Suzuki, Jun Takahashi, Yukio Nakamura","doi":"10.3177/jnsv.70.82","DOIUrl":"10.3177/jnsv.70.82","url":null,"abstract":"We investigated the effects of short-term dietary zinc deficiency on zinc and calcium metabolism. Four-week-old male Wistar rats were divided into two pair-fed groups for a 1-wk treatment: zinc-deficient group (ZD, 1 ppm); control group (PF, 30 ppm). The mRNA expression of zinc transporters, such as Slc39a (Zip) 4, Zip5, Zip10, and Slc30a (ZnT) 1, in various tissues (liver, kidney, and duodenum) quickly responded to dietary zinc deficiency. Although there was no significant difference in serum calcium concentrations between the PF and ZD groups, serum 1,25-dihydroxycholecalciferol (1,25(OH)2D3) was higher in the ZD group than in the PF group. Moreover, short-term zinc deficiency significantly increased mRNA expression of transient receptor potential (TRP) cation channel subfamily vanilloid (V) member 6, S100 calcium binding protein G (S100g), and ATPase plasma membrane Ca2+ transporting 1 (Atp2b1) in the duodenum. Furthermore, short-term zinc deficiency increased vitamin D receptor (VDR) and cytochrome P450 family 24 subfamily A member 1 (Cyp24a1) mRNA expression in the kidney. These findings suggested that short-term zinc deficiency maintains serum calcium concentrations through Ca absorption-related gene expression in the duodenum, and that short-term zinc deficiency induced the expression of Cyp24a1 in kidney in response to an increase in the serum 1,25(OH)2D3 level.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 1","pages":"82-87"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upregulation Effect of Citrus Species on Brain-Derived Neurotrophic Factor. 柑橘对脑神经营养因子的上调作用

IF 1.6 4区医学

Journal of nutritional science and vitaminology Pub Date : 2024-01-01 DOI: 10.3177/jnsv.70.61

Kensuke Nakajima, Ahreum Han, Arisa Kayano, Shigeru Oiso

{"title":"Upregulation Effect of Citrus Species on Brain-Derived Neurotrophic Factor.","authors":"Kensuke Nakajima, Ahreum Han, Arisa Kayano, Shigeru Oiso","doi":"10.3177/jnsv.70.61","DOIUrl":"10.3177/jnsv.70.61","url":null,"abstract":"Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays fundamental roles in neuronal survival and synaptic plasticity. Its upregulation in the brain can effectively prevent and treat central nervous system (CNS) diseases, including depression, Alzheimer's disease (AD), and Parkinson's disease (PD). BDNF is synthesized in various peripheral tissues as well as in the brain and can be transported from peripheral circulation into the brain through the blood-brain barrier. Therefore, foods that upregulate BDNF in peripheral tissues may be beneficial in preventing and treating these CNS diseases. Previously, we revealed that treatment with Chinpi (Citrus unshiu peel) and Citrus natsudaidai increased BDNF levels in the human renal adenocarcinoma cell line ACHN. Here, we evaluated the effects of 21 citrus cultivars on BDNF production in ACHN cells by measuring BDNF levels in the cell culture medium. We found that treatment with peels and pulps of 13 citrus varieties increased BDNF levels in ACHN cells. Treatment with Aurantium, Acrumen, and their hybrids citrus varieties showed a potent BDNF-upregulating effect but not with varieties belonging to Limonellus, Citrophorum, and Cephalocitrus. In addition, treatment with some of those Acrumen and its hybrid citrus species resulted in elevated levels of BDNF transcripts in ACHN cells. These results suggest that peels of many citrus cultivars contain ingredients with a potential BDNF-upregulating ability, which may be novel drug seeds for treating depression, AD, and PD. Furthermore, many citrus cultivars could be used as BDNF-upregulating foods.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"70 1","pages":"61-71"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0