Journal of nutritional science and vitaminology最新文献_第5页

The Impact of Skipping Breakfast on Academic Performance in Youths: A Meta-Analysis of Observational Studies. 不吃早餐对青少年学业成绩的影响：观察性研究的荟萃分析。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.339

Takahiro Seura, Riko Nagai, Sara Yamazaki, Kenichi Bando, Misako Sogawa

{"title":"The Impact of Skipping Breakfast on Academic Performance in Youths: A Meta-Analysis of Observational Studies.","authors":"Takahiro Seura, Riko Nagai, Sara Yamazaki, Kenichi Bando, Misako Sogawa","doi":"10.3177/jnsv.71.339","DOIUrl":"10.3177/jnsv.71.339","url":null,"abstract":"Academic performance, assessed through tests and assignments, significantly influences long-term outcomes, such as employment, income, and quality of life. Several recent studies have indicated a relationship between skipping breakfast and academic performance; however, no meta-analysis has been performed to explore this association. In the present study, we conducted a meta-analysis of observational studies to synthesize the association between skipping breakfast and academic performance in youths. We perused the literature published before October 2024 using PubMed, Science Direct, Springer Link, and Scopus. We calculated a pooled odds ratio (OR) with 95% confidence interval (95% CI) using a random effects model. The study quality was assessed using the Newcastle-Ottawa Scale adapted for cross-sectional studies. With regard the quality of the included studies, two articles were considered unsatisfactory, five as satisfactory, sixteen as good, and two as very good. After screening, 24 observational studies with 37 reports were included in the meta-analysis. A positive association was observed between skipping breakfast and the risk of poor academic performance (pooled OR=2.08, 95% CI=1.82-2.37). Subgroup analyses based on gender, region, sample size, assessment tools, definition of outcomes, and confounding variables also revealed that skipping breakfast is positively correlated with poor academic performance in youths. In conclusion, this meta-analysis indicates that skipping breakfast is positively associated with poor academic performance in youths.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 4","pages":"339-348"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the Inhibitory Effects of Fatty Acid Derivatives on URAT1 Function, a Renal Urate Re-Absorber. 脂肪酸衍生物对肾尿酸再吸收剂URAT1功能抑制作用的研究。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.331

Yu Toyoda, Hiroki Saito, Hiroshi Hirata, Ami Ota-Kontani, Youichi Tsuchiya, Tappei Takada

{"title":"Investigation of the Inhibitory Effects of Fatty Acid Derivatives on URAT1 Function, a Renal Urate Re-Absorber.","authors":"Yu Toyoda, Hiroki Saito, Hiroshi Hirata, Ami Ota-Kontani, Youichi Tsuchiya, Tappei Takada","doi":"10.3177/jnsv.71.331","DOIUrl":"https://doi.org/10.3177/jnsv.71.331","url":null,"abstract":"The global increase in hyperuricemia, a pathological condition characterized by elevated serum urate concentrations, emphasizes the importance of appropriate management of uric acid homeostasis in the body. Enhancing renal urate excretion is clinically relevant to achieve serum urate-lowering, and the functional inhibition of urate transporter 1 (URAT1), a renal urate transporter involved in the reabsorption of urate, has been recognized as a promising strategy. In this context, natural substances, including food ingredients with URAT1-inhibitory activity, have garnered significant interest. A previous study demonstrated that various fatty acids, including α-linolenic acid (α-LA), inhibit URAT1; however, further investigations are required to expand our understanding for this important topic. The present study focused on certain metabolites derived from α-LA, especially jasmonates (lipid-derived cyclopentanone compounds in plants) and related substances, and investigated their effects on URAT1-mediated urate transport activity, using a mammalian cell-based functional assay system. Among the tested substances (14 authentic chemicals), 12-oxo-phytodienoic acid (a precursor of jasmonic acid harboring a cyclopentenone ring with two carbon chains in its structure) showed a good URAT1-inhibitory activity with the half maximal inhibitory concentration (IC50) value of 15.9 μM. Comparable results were obtained with prostaglandin A1 (PGA1) and PGA2, which are known as cyclopentenone PGs, that exhibited IC50 values of 22.5 μM and 16.8 μM, respectively. Although further studies are required to address the effects of these substances on the urate regulation in humans, our findings contribute to a deeper understanding of the interactions between URAT1 and natural substances.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 4","pages":"331-338"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functions of Coffee Fermented by Rhizopus oligosporus. 寡孢根霉发酵咖啡的功能研究。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.386

Shin Nishiumi, Tatsuo Nakahara, Mei Kimura, Chihiro Fujiwara, Aki Hayakawa, Sara Hosoki, Hana Kato, Karen Kuroki, Miki Nakano, Rikako Sakamoto, Mio Yamaoka

{"title":"Functions of Coffee Fermented by Rhizopus oligosporus.","authors":"Shin Nishiumi, Tatsuo Nakahara, Mei Kimura, Chihiro Fujiwara, Aki Hayakawa, Sara Hosoki, Hana Kato, Karen Kuroki, Miki Nakano, Rikako Sakamoto, Mio Yamaoka","doi":"10.3177/jnsv.71.386","DOIUrl":"https://doi.org/10.3177/jnsv.71.386","url":null,"abstract":"Rhizopus oligosporus (R. oligosporus) is a fungus belonging to the Mucoraceae and is usually used to ferment soybeans in East Asia. R. oligosporus-fermented soybeans are called tempeh and are mainly eaten in East Asia. The recent researches have demonstrated that R. oligosporus can also ferment the beans other than soybeans. In this study, raw coffee beans were fermented with R. oligosporus, and then the effects of coffee prepared from the fermented beans were investigated. The amounts of fats and saccharides were lower in the R. oligosporus-fermented coffee beans than in the unfermented coffee beans, but the amount of dietary fiber was increased in the fermented coffee beans. The R. oligosporus-fermented coffee exhibited decreased total polyphenol levels, and its antioxidant activity was also reduced. However, the concentration of chlorogenic acid, which is one of polyphenols, in the R. oligosporus-fermented coffee was higher than that in the unfermented coffee. In comparison to the unfermented coffee, the R. oligosporus-fermented coffee inhibited α-amylase and α-glucosidase activity more strongly, inhibited cancer growth more weakly or to a similar level, and inhibited H2O2-induced reactive oxygen species production more weakly. The inhibition of α-amylase and α-glycosidase activity is considered to contribute to the prevention of obesity and diabetes. Fermenting raw coffee beans with R. oligosporus may contribute to improving certain effects of coffee, especially the preventative effects against obesity and diabetes.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 4","pages":"386-393"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Calcium Alginate on the Suppression of Postprandial Elevation of Serum Triglyceride Level in Humans-A Placebo-Controlled, Randomized, Double-Blind, Crossover Study. 海藻酸钙对人类餐后血清甘油三酯水平升高的抑制作用——一项安慰剂对照、随机、双盲、交叉研究

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.467

Yusuke Namiki, Satsuki Kimura, Risa Sasaki, Yoko Homma, Chihiro Miyajima, Fumiyoshi Kasahara, Atsushi Kuwabara, Takuo Ogihara

{"title":"Effect of Calcium Alginate on the Suppression of Postprandial Elevation of Serum Triglyceride Level in Humans-A Placebo-Controlled, Randomized, Double-Blind, Crossover Study.","authors":"Yusuke Namiki, Satsuki Kimura, Risa Sasaki, Yoko Homma, Chihiro Miyajima, Fumiyoshi Kasahara, Atsushi Kuwabara, Takuo Ogihara","doi":"10.3177/jnsv.71.467","DOIUrl":"10.3177/jnsv.71.467","url":null,"abstract":"In this study, the effect of calcium alginate (Ca-Alg) on postprandial serum triglycerides (TG) was examined in healthy adults in a placebo-controlled, randomized, double-blind, crossover study. Eight healthy adults were given a fat-loaded food followed by placebo or 1.5 g (300 mg/capsule×5) of Ca-Alg, and serum TG and remnant-like lipoprotein cholesterol (RLP-C) levels were measured before and at various times (2, 3, 4 and 6 h) after consumption of the fat-loaded food. The results showed that TG and RLP-C levels were significantly lower at all time points in the Ca-Alg intake group compared to the control group, starting 2 h after consumption of the fat-loaded food. The area under the time curve (AUC0-6h) and the highest level observed (Cmax) up to 6 h after the food were also significantly lower in the Ca-Alg intake group than in the control group. Furthermore, biochemical analyses revealed that at 6 h after consumption of the fat-loaded food, ΔCa (change in serum calcium concentration) was significantly increased, whereas ΔNa (change in serum sodium concentration) was significantly decreased in the Ca-Alg intake group compared to the control group. These results indicate that Ca-Alg may have broad applications as a supplement that also contributes to the prevention of lifestyle-related diseases such as hyperlipidemia.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 5","pages":"467-473"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

11,12-Epoxyeicosatrienoic Acid Attenuates Adipose Inflammation in Diet-Induced Obese Mice. 11,12-环氧二碳三烯酸减轻饮食诱导的肥胖小鼠的脂肪炎症。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.427

Huichen Zhao, Xiaoli Ma, Xiaocheng Yan, Xiaodong Zhao, Xinguo Hou, Yuchao Zhang, Yuantao Liu

{"title":"11,12-Epoxyeicosatrienoic Acid Attenuates Adipose Inflammation in Diet-Induced Obese Mice.","authors":"Huichen Zhao, Xiaoli Ma, Xiaocheng Yan, Xiaodong Zhao, Xinguo Hou, Yuchao Zhang, Yuantao Liu","doi":"10.3177/jnsv.71.427","DOIUrl":"https://doi.org/10.3177/jnsv.71.427","url":null,"abstract":"Epoxyeicosatrienoic acids (EETs), the epoxidation products of arachidonic acid, were shown to have vasodilation and anti-inflammatory activity in many tissues. In the present study, the roles and mechanisms of EETs in the development of inflammation in adipose tissue were investigated in obese mice. Diet-induced obesity models were established on male C57BL/6 mice, and randomly divided into three groups: OB group (saline), EET group (11,12-EET), or EEZE group (14,15-epoxyeicosa-5(Z)-enoicacid). The levels of cytochrome P450 (CYP) 2J6, hypoxia inducible factor (HIF)-1α, 11,12-EET, interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α were determined. Angiogenesis was evaluated with platelet endothelial cell adhesion molecule-1 (CD31); Insulin resistance was evaluated with homeostasis model assessment of insulin resistance (HOMA-IR). In diet-induced obese mice, CYP2J6 expression in both mRNA and protein levels was downregulated and 11,12-EET level was reduced, levels of IL-6, IL-1β, TNF-α, and HIF-1α were increased in epididymal adipose tissue and in serum compared with non-obese controls. These changes were attenuated by exogenous 11,12-EET, whereas but aggravated by 14,15-EEZE, an EET antagonist. CD31-positive cells in the epididymal adipose tissue of obese mice were markedly reduced, which was significantly improved by 11,12-EET. HOMA-IR was increased but markedly attenuated by 11,12-EET in obese mice. These findings indicate that dysregulation of the CYP epoxygenases/EETs pathway may contribute to adipose inflammation in diet-induced obese mice. Exogenous EETs may attenuate adipose inflammation through modulation of adipose angiogenesis and hypoxia, which may have a favorable effect on systemic insulin resistance.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 5","pages":"427-434"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between the Degree of Health and Food Stockpiling for Disaster among Japanese Adults. 日本成年人健康程度与备灾食品储备的关系

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.498

Xin Liang, Nobuyo Tsuboyama-Kasaoka, Shuichi Uehara, Motoyoshi Kubo, Kozue Miyashiro, Takayuki Ishikawa, Reiko Ohmori

{"title":"Association between the Degree of Health and Food Stockpiling for Disaster among Japanese Adults.","authors":"Xin Liang, Nobuyo Tsuboyama-Kasaoka, Shuichi Uehara, Motoyoshi Kubo, Kozue Miyashiro, Takayuki Ishikawa, Reiko Ohmori","doi":"10.3177/jnsv.71.498","DOIUrl":"10.3177/jnsv.71.498","url":null,"abstract":"Natural disasters have occurred frequently in Japan and are currently the focus of much attention. The objective of this study is to investigate the association between the degree of health and food stockpiling for disasters across Japan. This study conducted an online survey from November 25 to 29, 2022, via a self-administered web-based questionnaire. The sample for this study consisted of 2,000 individuals over the age of 20 who registered with an online survey company. The associations between the degree of health and food stockpiling for disasters were analyzed (n=1,634). Only 11.9% of the participants had a high level of health, whereas 52.5% had a low level. Fewer than half of the participants had a middle level of health (35.6%). A multivariable logistic regression analysis was conducted to examine the association between the degree of health and food stockpiling for disasters. The analysis revealed a significant positive association between the degree of health and food stockpiling behavior for disasters. The levels of health, physical health and social health were significantly positively related to food stockpiling. Therefore, it is crucial to focus on personality traits to promote food stockpiling for disasters. This study emphasized that the degree of health should receive more attention in research, which could help promote food stockpiling for disasters.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 5","pages":"498-506"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Retrospective Study of the Association between Low Vitamin B1 in the Blood and Cognitive Impairment in Patients with Alzheimer's Disease. 阿尔茨海默病患者血液中维生素B1含量低与认知功能障碍关系的回顾性研究

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.421

Yuji Higaki, Yu Kobayashi

{"title":"A Retrospective Study of the Association between Low Vitamin B1 in the Blood and Cognitive Impairment in Patients with Alzheimer's Disease.","authors":"Yuji Higaki, Yu Kobayashi","doi":"10.3177/jnsv.71.421","DOIUrl":"10.3177/jnsv.71.421","url":null,"abstract":"This retrospective observational study investigated the association between low vitamin B1 (VB1) levels and cognitive impairment in 77 Japanese patients with Alzheimer's disease (AD). Multivariable regression analysis identified a significant correlation between low VB1 levels (<2.6 μg/dL) and lower Mini-Mental State Examination (MMSE) scores. Fisher's exact test demonstrated a strong association between VB1 deficiency and cognitive impairment (p=0.001). Scatter plot analysis supported these findings, illustrating a dose-dependent trend: patients with severe VB1 deficiency consistently exhibited low cognitive function, while those with higher VB1 levels showed better MMSE scores. In contrast, VB12 and folate levels showed no clear association with cognitive function. These results, together with animal studies, suggest that VB1 deficiency may contribute to AD-related neurodegeneration. While benfotiamine, a lipid-soluble VB1 derivative, has been suggested to improve cognition, its causal effect remains uncertain due to the study's cross-sectional design. Selection bias and the lack of dietary data are also limitations. Further longitudinal research is needed to determine whether VB1 supplementation could help mitigate cognitive decline in AD patients.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 5","pages":"421-426"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural and Functional Characteristics of FMN-Dependent NADPH-Indigo Reductase Homolog from Bacillus cohnii. 玉米芽孢杆菌fmn依赖性nadph -靛蓝还原酶同源物的结构和功能特征。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.180

Kazunari Yoneda, Haruhiko Sakuraba, Junji Hayashi, Yuki Naruse, Tomohiro Araki, Toshihisa Ohshima

引用次数: 0

Brazilian Green Propolis Regulates Thermogenesis via Two Distinct Pathways. 巴西绿蜂胶通过两种不同的途径调节产热。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.375

Takuma Hyodo, Nobuaki Okumura, Takanori Tsuda

{"title":"Brazilian Green Propolis Regulates Thermogenesis via Two Distinct Pathways.","authors":"Takuma Hyodo, Nobuaki Okumura, Takanori Tsuda","doi":"10.3177/jnsv.71.375","DOIUrl":"https://doi.org/10.3177/jnsv.71.375","url":null,"abstract":"Brazilian green propolis (BGP), produced by honey bees, induces beige adipocyte formation and accelerates whole-body energy metabolism. Artepillin C (ArtC), the major cinnamic acid derivative of BGP, induces beige adipocyte formation and increases thermogenesis in inguinal white adipose tissue. However, the effects of BGP on beige adipocyte formation and energy metabolism remain unclear. Therefore, we aimed to examine the effects of BGP on beige adipocyte formation and thermogenesis. We used in vitro and in vivo approaches, such as cell culture and differentiation, component testing, thermogenesis measurement, and calcium influx assay. First, ArtC was confirmed to be a major BGP component contributing to beige adipocyte formation in vitro and in vivo. BGP-induced interscapular brown adipose tissue (iBAT) thermogenesis was not observed upon ArtC stimulation. Thereafter, inhibitory studies revealed that iBAT thermogenesis could be related to the transient receptor potential vanilloid 1 (TRPV1)-sympathetic nervous system channel. Finally, we identified culifolin, a cinnamic acid derivative of BGP, as an active component of this response, which activates calcium signaling in TRPV1-expressing cells. In addition, culifolin administration significantly increased the mouse iBAT temperature to the same extent as increased by BGP. Thus, BGP has a unique biological function in activating the two distinct pathways of brown-adipocyte and beige-adipocyte thermogenesis, contributing to increased energy expenditure.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 4","pages":"375-385"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the Efficacy of Pre-Germinated Brown Rice Extract and γ-Oryzanol against Non-Alcoholic Fatty Liver Disease and Cardiac Complications Induced by a High-Fructose/Fat Diet. 预发芽糙米提取物和γ-谷米醇对高果糖/高脂肪饮食诱导的非酒精性脂肪性肝病和心脏并发症的疗效比较

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.321

Bin-Nan Wu, Hui-Li Lin, Huey-Jen Su, Pei-Wen Cheng, Ya-Mei Chen, Chi-Long Hao, Kuo-Ping Shen

{"title":"Comparison of the Efficacy of Pre-Germinated Brown Rice Extract and γ-Oryzanol against Non-Alcoholic Fatty Liver Disease and Cardiac Complications Induced by a High-Fructose/Fat Diet.","authors":"Bin-Nan Wu, Hui-Li Lin, Huey-Jen Su, Pei-Wen Cheng, Ya-Mei Chen, Chi-Long Hao, Kuo-Ping Shen","doi":"10.3177/jnsv.71.321","DOIUrl":"https://doi.org/10.3177/jnsv.71.321","url":null,"abstract":"This animal experiment aimed to evaluate the efficacy of the extract of pre-germinated brown rice (EP) and γ-oryzanol on non-alcoholic fatty liver disease (NAFLD) and the cardiac complications associated with it. WKY rats were fed high-fructose water (HFW) and high-fat diet (HFD) for 4 wk to induce NAFLD. The other two groups were fed HFW and HFD, while oral administration of EP 200 μL/kg or γ-oryzanol 2 mg/kg every day for 4 wk. NAFLD was successfully induced in as evidenced by clear increases in body, hepatic and cardiac weight as well as by increases in blood pressure and heart rate, hypertriglyceridemia, hyperuricemia, higher liver function index: glutamic pyruvic transaminase (GPT), higher levels of IL-6 and TNF-α in the blood and higher levels TG in the liver. NAFLD rats also had adverse changes the protein expressions of lipid synthesis, inflammation, cardiac fibrosis and hypertrophy. However, when the NAFLD rats were simultaneously fed EP or γ-oryzanol, the development of adverse diet-induced effects, including glutamic oxaloacetic transaminase (GOT), were clearly ameliorated. Specifically, EP could reduce uric acid levels, while γ-oryzanol did not. EP, as well as γ-oryzanol, reversed the increases in levels of lipid synthesis, inflammation, cardiac fibrosis and hypertrophy. We concluded that EP effectively prevented HFW/HFD-induced NAFLD and its associated cardiac complications, which it likely achieved through an improvement of lipid homeostasis and inhibition of inflammation. We believe that EP, like γ-oryzanol, can be developed as a beneficial agent for the prevention and control of NAFLD and associated cardiac dysfunction.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 4","pages":"321-330"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0