Journal of nutritional science and vitaminology最新文献_第4页

High Proportions of Low Body Mass Index and Menstrual Dysfunction among Rhythmic Gymnasts: Association with Body Image Distortion and Eating Behaviors and Attitudes. 艺术体操运动员高比例低体重指数和月经功能障碍：与身体形象扭曲和饮食行为态度的关系。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.519

Kayo Yoshitani-Kuwabara, Yukina Yumen, Yumi Takayama, Natsuho Kitayama, Narumi Nagai

{"title":"High Proportions of Low Body Mass Index and Menstrual Dysfunction among Rhythmic Gymnasts: Association with Body Image Distortion and Eating Behaviors and Attitudes.","authors":"Kayo Yoshitani-Kuwabara, Yukina Yumen, Yumi Takayama, Natsuho Kitayama, Narumi Nagai","doi":"10.3177/jnsv.71.519","DOIUrl":"https://doi.org/10.3177/jnsv.71.519","url":null,"abstract":"In aesthetic sports, a visually appealing physique is often deemed advantageous; however, excessive dietary restrictions may lead to health risks. We hypothesized that rhythmic gymnasts exhibit higher proportions of low body mass index (low BMI, <18.5 kg/m2) and menstrual dysfunction (MD) compared with not only non-aesthetic sports athletes but also non-athlete women. We measured BMI, menstruation conditions, body image (BI) distortion, Eating Attitude Test (EAT-26) scores, and eating behaviors in three female groups: rhythmic gymnasts (n=40), volleyball players as non-aesthetic sports athletes (n=46), and age-matched non-athletes (n=108). Logistic regression analyses were conducted to identify risk factors for low BMI and MD. The rhythmic gymnasts had significantly higher rates of low BMI and MD (p<0.001), greater BI distortion (p<0.05) and EAT-26 scores (p<0.001), and more frequent breakfast skipping (p<0.05) than the other two groups. Logistic regression analyses revealed that being a rhythmic gymnast and BI distortion (overestimation) were independently associated with a low BMI, and higher EAT-26 scores were independently associated with MD. These findings suggest that low BMI and MD are prevalent among rhythmic gymnasts and BI distortion and unhealthy eating attitudes may be associated with these conditions. Further research is required to prevent being underweight and related health risks among female athletes in various aesthetic sports.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 6","pages":"519-525"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wheat Alkylresorcinols Induce Non-Rapid Eye Movement Sleep by Reducing Core Body Temperature in Mice. 小麦烷基间苯二酚通过降低小鼠核心体温诱导非快速眼动睡眠。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.574

Katsutaka Oishi, Hiroki Okauchi, Sayaka Higo-Yamamoto

{"title":"Wheat Alkylresorcinols Induce Non-Rapid Eye Movement Sleep by Reducing Core Body Temperature in Mice.","authors":"Katsutaka Oishi, Hiroki Okauchi, Sayaka Higo-Yamamoto","doi":"10.3177/jnsv.71.574","DOIUrl":"https://doi.org/10.3177/jnsv.71.574","url":null,"abstract":"Wheat alkylresorcinols (ARs) possess several biological activities that include antioxidative and neuroprotective properties. The effects of ARs on sleep regulation remain unknown. In this study, we hypothesized that ARs may contribute to the sleep-improving effects of whole grains. Male C3H/HeN mice were individually housed under a 12-h light-12-h dark cycle and intragastrically injected with vehicle or ARs at the time of lights off (activity onset). We then continuously monitored electrical activity in the brain using polygraphic electroencephalography, spontaneous locomotor activity, and subcutaneous and core body temperatures in the mice. An initial decrease in core body temperature was followed by decreased subcutaneous body temperature, locomotor activity, wakefulness, and increased non-rapid eye movement sleep for several hours in the mice injected with ARs. These findings suggested that ARs improve sleep onset by reducing core body temperature. Further studies are required to elucidate the molecular mechanism of the effects of ARs on body temperature and sleep regulation.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 6","pages":"574-577"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Patterns and Premenstrual Syndrome: A Cross-Sectional Study. 饮食模式和经前综合症：一项横断面研究。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.568

Akiko Nanri, Michi Nakamura, Takashi Takeda, Masanori Ohta

{"title":"Dietary Patterns and Premenstrual Syndrome: A Cross-Sectional Study.","authors":"Akiko Nanri, Michi Nakamura, Takashi Takeda, Masanori Ohta","doi":"10.3177/jnsv.71.568","DOIUrl":"10.3177/jnsv.71.568","url":null,"abstract":"This study investigated the cross-sectional association between major dietary patterns and premenstrual syndrome (PMS). Participants were 427 women aged 22-50 y who responded to a mail survey in 2022-2023. Dietary patterns were derived using principal component analysis based on consumption of 52 food and beverage items ascertained by a validated self-administered diet history questionnaire. PMS were assessed using the Premenstrual Symptoms Questionnaire. Logistic regression analysis was used to estimate odds ratios of PMS according to tertiles of dietary pattern scores. The prevalence of moderate to severe PMS was 9.6% (41 women). We identified four dietary patterns: vegetable, tomato and fish, Japanese, and alcohol dietary patterns. No dietary pattern was significantly associated with PMS. However, the odds ratios of PMS in the highest tertile of the vegetable dietary pattern (characterized by high intake of vegetables, mushrooms, potatoes, seaweeds, and chicken) tended to be lower compared to the lowest tertile. The multivariable-adjusted odds ratio of PMS for the highest versus lowest tertile of the vegetable dietary pattern score was 0.69 (95% confidence interval 0.30-1.59). None of the dietary patterns were appreciably associated with PMS. The finding of lower odds of PMS among women with a high score for the vegetable dietary pattern deserves further investigation.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 6","pages":"568-573"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Powdered Morus australis Leaves on Arterial Stiffness Response after Sucrose Ingestion in Healthy Young Men: A Pilot Study. 桑叶粉对健康青年摄入蔗糖后动脉僵硬反应的影响：一项初步研究。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.63

Daisuke Kume, Masato Nishiwaki, Masaaki Ito

{"title":"Effect of Powdered Morus australis Leaves on Arterial Stiffness Response after Sucrose Ingestion in Healthy Young Men: A Pilot Study.","authors":"Daisuke Kume, Masato Nishiwaki, Masaaki Ito","doi":"10.3177/jnsv.71.63","DOIUrl":"10.3177/jnsv.71.63","url":null,"abstract":"Acute arterial stiffening occurs during postprandial hyperglycemia. Such vascular responses are suggested to be averted by suppressing the postprandial glycemic response. We previously developed an α-glucosidase-inhibiting tea powder from the leaves of Morus australis (M. australis), a mulberry species distributed in the Ryukyu Islands, and demonstrated that this powder has an inhibitory effect on blood glucose elevation after sucrose ingestion. This study aimed to investigate the effect of powdered M. australis leaf intake on the arterial stiffness response after sucrose ingestion. In a randomized crossover design, 12 healthy young men completed two trials: with (mulberry [M] trial) and without (control [C] trial) intake of powdered M. australis leaves before ingestion of 75 g of sucrose. Blood glucose levels and brachial-ankle pulse wave velocity (baPWV), an index of systemic arterial stiffness, were measured at baseline and 30, 60, and 120 min after ingestion. Both trials caused a significant increase in blood glucose levels at 30 and 60 min after ingestion, with significantly lower values at 30 min after ingestion in the M trial than in the C trial. baPWV significantly increased at 60 min after ingestion in the C trial, but not in the M trial. These findings demonstrate that prior ingestion of powdered M. australis leaves can prevent the transient arterial stiffening after sucrose ingestion in healthy young men.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 1","pages":"63-69"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Nutrition Education for Breakfast Intake on Morning Gastric Motility in High School Students Living in Dormitories. 早餐营养教育对宿生早晨胃动力的影响。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.277

Shiori Wakisaka, Yukina Yumen, Yumi Takayama, Kayo Yoshitani, Miyoko Okuzono, Akari Iwami, Narumi Nagai

{"title":"The Effects of Nutrition Education for Breakfast Intake on Morning Gastric Motility in High School Students Living in Dormitories.","authors":"Shiori Wakisaka, Yukina Yumen, Yumi Takayama, Kayo Yoshitani, Miyoko Okuzono, Akari Iwami, Narumi Nagai","doi":"10.3177/jnsv.71.277","DOIUrl":"https://doi.org/10.3177/jnsv.71.277","url":null,"abstract":"Skipping breakfast is observed in approximately 30% of youth. Since gastric motility is involved in morning appetite, we conducted a 2-wk nutrition education program for high school dormitory students to encourage breakfast consumption and examined whether gastric myoelectrical activity before breakfast was improved. Gastric motility was assessed by measuring the dominant frequency (DF), derived from power spectrum analysis of normal waves occurring approximately three times per minute, and the percentage (%) normal power. Participants were divided into a normal-gastric motility group (Normal-GM, DF ≥ 2.5 cpm, % normal power ≥50%, n=10) and a low-gastric motility group (Low-GM, DF<2.5 cpm, % normal power <50%, n=7) based on the morning gastric motility index. Nutrition education (i.e. the intervention) was provided to all participants and the same measurements were taken 2 wk later. The results showed an improvement in DF in the Low-GM group (1.99±0.09 cpm to 2.90±0.22 cpm, p=0.008) after the intervention. In addition, % normal power increased significantly only in the Low-GM group (42.9±2.6% to 54.2±2.9%, p=0.047). These results suggest that regular breakfast consumption may help normalize lower morning gastric motility in high school students.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 3","pages":"277-282"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Amino Acid and Fatty Acid in Seafood, Meat, Beans, and Eggs Using the Food Composition Table. 用食品成分表比较海鲜、肉类、豆类和鸡蛋中的氨基酸和脂肪酸。

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.211

Hisami Yamanaka-Okumura, Shiori Yamamoto, Miyu Kenzaka, Sae Nakao, Sari Natsume, Haruka Nishiyama, Miyuki Imafuku, Chika Oue, Yutaka Taketani

{"title":"Comparison of Amino Acid and Fatty Acid in Seafood, Meat, Beans, and Eggs Using the Food Composition Table.","authors":"Hisami Yamanaka-Okumura, Shiori Yamamoto, Miyu Kenzaka, Sae Nakao, Sari Natsume, Haruka Nishiyama, Miyuki Imafuku, Chika Oue, Yutaka Taketani","doi":"10.3177/jnsv.71.211","DOIUrl":"https://doi.org/10.3177/jnsv.71.211","url":null,"abstract":"Nutritional guidance typically uses protein and lipid intake rather than amino acids and fatty acids. However, the composition of amino acids and fatty acids varies depending on the food source, requiring detailed analysis for accurate dietary assessment. Currently, limited research exists on the detailed composition of foods commonly consumed in Japan. Therefore, we aimed to compare the characteristics of amino acid and fatty acid in foods that are the major sources of protein in the Japanese diet. Data cleaning was performed on 2,478 foods listed in the Food Composition Table 2020 (8th revision). Heatmap cluster analysis was performed for food groups, amino acid, and fatty acid, and statistical analysis was performed to determine the percentage differences between food groups. Heat map cluster analysis of the fish and meat data showed that the foods were divided into two groups in the first level (fish and meat). Characteristic amino acid and fatty acid were 5/8 for meat, 1/27 for fish, and 13/0 for common, and no common fatty acid were noted. Significant differences were found between nine amino acids and 31 fatty acids. Heat map cluster analysis using data on seafood, meat, legumes, and eggs showed that foods could be classified into two clusters at the first level: seafood and meat, with legumes and eggs included in the meat cluster. The results of the heat map cluster analysis using statistical analysis and means indicated that seafood, meat, and legumes were characterized differently, especially in terms of fatty acid.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 3","pages":"211-222"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between the Frequency of the Combined Staple, Main, and Side Dishes Examined Using a Validated Questionnaire and the Intake of Nutrients and Food Groups among Young and Middle-Aged Japanese Adults: Results from the DOSANCO Health Study: A Cross-Sectional Study. 使用有效问卷调查的主食、主食和配菜的组合频率与日本青壮年成年人营养物质和食物种类的摄入量之间的关系：来自DOSANCO健康研究的结果：一项横断面研究。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.201

Akinori Yaegashi, Emiko Okada, Takashi Kimura, Koshi Nakamura, Shigekazu Ukawa, Takafumi Nakagawa, Akihiro Imae, Mami Matsushita, Yukiko Minegishi, Izumi Momose, Mari Shimizu, Junko Suzuki, Chizuru Kubo, Atsuko Yamaguchi, Manabu Musashi, Iwao Ohkubo, Akiko Tamakoshi

{"title":"Association between the Frequency of the Combined Staple, Main, and Side Dishes Examined Using a Validated Questionnaire and the Intake of Nutrients and Food Groups among Young and Middle-Aged Japanese Adults: Results from the DOSANCO Health Study: A Cross-Sectional Study.","authors":"Akinori Yaegashi, Emiko Okada, Takashi Kimura, Koshi Nakamura, Shigekazu Ukawa, Takafumi Nakagawa, Akihiro Imae, Mami Matsushita, Yukiko Minegishi, Izumi Momose, Mari Shimizu, Junko Suzuki, Chizuru Kubo, Atsuko Yamaguchi, Manabu Musashi, Iwao Ohkubo, Akiko Tamakoshi","doi":"10.3177/jnsv.71.201","DOIUrl":"10.3177/jnsv.71.201","url":null,"abstract":"To clarify the association between the intake frequency of a meal combination of staple, main, and side dishes (SMS meal), determined using a validated questionnaire, and the intake of various nutrients and food groups among Japanese adults. In this cross-sectional study, we analyzed data from 936 persons aged 18-64 y who participated in the Dynamics of Lifestyle and Neighborhood Community on Health Study. The intake frequency of SMS meals was assessed using our validated questionnaire and validated. The intake of nutrients and food groups was examined using validated food-frequency questionnaires. To examine the association of the intake frequency of SMS meals with the intake of specific nutrients and food groups, linear regression analysis was conducted with adjustment for age, body mass index, education history, living status (alone or not), smoking status, and alcohol drinking. The intake frequency of SMS meals was significantly positively associated with the intake of 24/32 nutrients in men, 8/32 nutrients in women, 6/16 food groups in men, and 1/16 food groups in women, and significantly negatively associated with 2/16 food groups in men. A higher intake frequency of SMS meals was not significantly associated with a higher intake of salt or saturated fats. Our results suggest that a higher intake frequency of SMS meals, examined using a validated questionnaire, may be associated with a higher intake of certain nutrients and food groups among young and middle-aged adults without a higher intake of salt and saturated fats.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 3","pages":"201-210"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Ascorbic Acid Levels and Hepatic L-Gulonolactone Oxidase Activity in KK-Ay Mice and Streptozotocin-Diabetic Mice under Hyperglycemic Conditions. 高血糖条件下KK-Ay小鼠和链脲霉素糖尿病小鼠抗坏血酸水平和肝脏l -古罗内酯氧化酶活性的比较

IF 0.7 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.101

Keizo Umegaki, Kaori Yokotani, Kanna Ieiri, Hiroaki Kawasaki

{"title":"Comparison of Ascorbic Acid Levels and Hepatic L-Gulonolactone Oxidase Activity in KK-Ay Mice and Streptozotocin-Diabetic Mice under Hyperglycemic Conditions.","authors":"Keizo Umegaki, Kaori Yokotani, Kanna Ieiri, Hiroaki Kawasaki","doi":"10.3177/jnsv.71.101","DOIUrl":"https://doi.org/10.3177/jnsv.71.101","url":null,"abstract":"Blood ascorbic acid (AsA) concentrations are lower in diabetic patients than in the general population, a phenomenon that is also observed in streptozotocin (STZ)-diabetic models of type 1 diabetes. However, the occurrence of diabetes in KK-Ay mice, a model for type 2 diabetes, the most common form of diabetes, remains unclear. Although this mouse can synthesize AsA, understanding its level changes during diabetes progression could help in analyzing AsA's effects on type 2 diabetes. Therefore, the present study investigated the relationship between hyperglycemia and AsA concentrations in the blood and organs of KK-Ay mice, and discussed the findings in relation to those observed in STZ-diabetic mice. Male KK-Ay mice were examined at different stages of diabetes (pre-diabetic, early onset, and hyperglycemic maintenance). STZ-diabetic mice were generated by administering STZ to ICR mice. AsA concentrations were measured in plasma, blood mononuclear cells, and tissues, along with hepatic L-gulonolactone oxidase (GLO) activity and mRNA expression levels. Unexpectedly, AsA concentrations in KK-Ay mice increased under hyperglycemic conditions, while they decreased in STZ-diabetic mice. A consistent relationship was not observed between organ AsA concentrations and hyperglycemia. GLO activity and mRNA expression levels increased in KK-Ay mice, but decreased in STZ-diabetic mice, suggesting an innate defense mechanism against hyperglycemia in KK-Ay mice. These results indicate that different diabetes models exhibit distinct changes in AsA concentrations and hepatic GLO activity under hyperglycemic conditions, highlighting the importance of considering endogenous AsA when evaluating the antioxidant properties of dietary components in KK-Ay mice.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 2","pages":"101-109"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Combined Tunicamycin and a High-Fat Diet Rich in Saturated Fatty Acids on the Development of Steatohepatitis. Tunicamycin联合富含饱和脂肪酸的高脂肪饮食对脂肪性肝炎发展的影响。

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.402

Chie Takahashi-Muto, Rieko Tanaka-Yachi, Chikako Kiyose

{"title":"Effects of Combined Tunicamycin and a High-Fat Diet Rich in Saturated Fatty Acids on the Development of Steatohepatitis.","authors":"Chie Takahashi-Muto, Rieko Tanaka-Yachi, Chikako Kiyose","doi":"10.3177/jnsv.71.402","DOIUrl":"https://doi.org/10.3177/jnsv.71.402","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is influenced by various factors including diet, genetic predisposition, adipocytokines, oxidative stress and endoplasmic reticulum (ER) stress. In this study, we examined how pre-feeding mice a high-fat diet rich in saturated fatty acids (SFAs) affected various indicators of liver disease after administering tunicamycin (TM), an ER stress inducer. We used 4-wk-old male C57BL/6J mice, dividing them into four groups: a normal diet (C), a high-fat diet (F), a normal diet with TM (CT), and a high-fat diet with TM (FT). After 8 wk of feeding, we administered TM intraperitoneally to the CT and FT groups, followed by an anatomical examination 24 h later. TM administration led to increased triglyceride (TG) and cholesterol accumulation in the liver, while significantly lowering TG, cholesterol, and ApoB levels in the plasma. Although liver TG levels were higher in the CT group compared to the FT group, large lipid droplets were present in all individuals only in the FT group. Classic non-alcoholic steatohepatitis markers, such as neutrophil infiltration and hepatocyte ballooning, were not observed. Additionally, plasma alanine aminotransferase activity and expression levels of ER stress-related proteins were significantly higher in the FT group than in the CT or F groups. These findings indicate that combining a high-fat diet rich in SFAs with TM exacerbates ER stress-induced fatty liver disease. This model may be a valuable tool for preclinical trials aimed at addressing ER stress in early-stage NAFLD.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 5","pages":"402-410"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Calcium Alginate on the Suppression of Postprandial Elevation of Serum Triglyceride Level in Humans-A Placebo-Controlled, Randomized, Double-Blind, Crossover Study. 海藻酸钙对人类餐后血清甘油三酯水平升高的抑制作用——一项安慰剂对照、随机、双盲、交叉研究

IF 1.1 4区医学

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI: 10.3177/jnsv.71.467

Yusuke Namiki, Satsuki Kimura, Risa Sasaki, Yoko Homma, Chihiro Miyajima, Fumiyoshi Kasahara, Atsushi Kuwabara, Takuo Ogihara

{"title":"Effect of Calcium Alginate on the Suppression of Postprandial Elevation of Serum Triglyceride Level in Humans-A Placebo-Controlled, Randomized, Double-Blind, Crossover Study.","authors":"Yusuke Namiki, Satsuki Kimura, Risa Sasaki, Yoko Homma, Chihiro Miyajima, Fumiyoshi Kasahara, Atsushi Kuwabara, Takuo Ogihara","doi":"10.3177/jnsv.71.467","DOIUrl":"10.3177/jnsv.71.467","url":null,"abstract":"In this study, the effect of calcium alginate (Ca-Alg) on postprandial serum triglycerides (TG) was examined in healthy adults in a placebo-controlled, randomized, double-blind, crossover study. Eight healthy adults were given a fat-loaded food followed by placebo or 1.5 g (300 mg/capsule×5) of Ca-Alg, and serum TG and remnant-like lipoprotein cholesterol (RLP-C) levels were measured before and at various times (2, 3, 4 and 6 h) after consumption of the fat-loaded food. The results showed that TG and RLP-C levels were significantly lower at all time points in the Ca-Alg intake group compared to the control group, starting 2 h after consumption of the fat-loaded food. The area under the time curve (AUC0-6h) and the highest level observed (Cmax) up to 6 h after the food were also significantly lower in the Ca-Alg intake group than in the control group. Furthermore, biochemical analyses revealed that at 6 h after consumption of the fat-loaded food, ΔCa (change in serum calcium concentration) was significantly increased, whereas ΔNa (change in serum sodium concentration) was significantly decreased in the Ca-Alg intake group compared to the control group. These results indicate that Ca-Alg may have broad applications as a supplement that also contributes to the prevention of lifestyle-related diseases such as hyperlipidemia.","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":"71 5","pages":"467-473"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0