Effects of Excessive Sucrose Intake on Aggressive Behavior and Peripheral Stress-Related Hormone and Catecholamines in BALB/c Mice during Adolescent Development.

Abstract

As binge eating and unbalanced diets increase the prevalence of obesity and metabolic disorders, it has been noted that the increase in psychiatric disorders is also a consequence of diet. The present study examined aggressive behavior and peripheral stress-related hormone and catecholamine levels in BALB/c mice fed a high-sucrose diet during adolescent development. BALB/c mice are rarely used in research assessing the effect of diet, but were used for ethnic and personal differences and as a new experimental model. BALB/c mice were fed a diet in which all carbohydrate components were replaced with sucrose for 4 wk and were subjected to the resident-intruder and social dominance tube test. Plasma insulin, corticosterone, and catecholamine levels were also compared to mice fed a control diet. The high-sucrose diet did not alter body weight, glucose tolerance, and plasma insulin levels in BALB/c mice, indicating that the diet was resilient to obesity. Mice fed a high-sucrose diet exhibited increased aggressive behaviors in the resident-intruder test and had a significantly higher win rate in the tube test. Increases in adrenal weight and plasma corticosterone as well as noradrenaline and adrenaline levels were exhibited in mice fed a high-sucrose diet. In particular, this is the first evidence of increased social dominance and hyperplasia of the adrenal glands by a sucrose diet. Sucrose diet intake increased aggression in mice and caused elevated peripheral hormones involving the HPA axis and the sympathetic nervous system, indicating that this may be a central nervous system-mediated effect of excess sucrose.