Journal of Ovarian Research最新文献

{"title":"Potential impact of air pollution on polycystic ovary syndrome incidence: a global analysis of 171 countries and regions from 1990 to 2021.","authors":"Yihao Chen, Yangyang Dai, Jiahua Qian, Yuhe Si, Fangyuan Chen, Zhiqing Hong, Jingwei Wang, Chunbao Mo, Jianxiong Ma","doi":"10.1186/s13048-025-01777-1","DOIUrl":"https://doi.org/10.1186/s13048-025-01777-1","url":null,"abstract":"<p><strong>Background: </strong>Although polycystic ovary syndrome (PCOS) incidence is associated with air pollution, the relationship between air pollution, especially fluctuations in global NO₂ concentrations, and the burden of PCOS remains unclear. In this ecological study, we aimed to investigate this relationship using the Global Burden of Disease 2021 dataset.</p><p><strong>Methods: </strong>Data on age-standardized incidence rates (ASIR) of PCOS were collected from 171 countries and regions over a 30-year period (1990-2021). Corresponding data on air pollution (NO₂, SO₂, particulate matter [PM], and O₃) and other indicators were also collected. Mixed linear models and geographic detectors were used to assess the relationship between various indicators and PCOS burden. Furthermore, the weighted quantile sum regressions were used to estimate the effect of multiple exposures to NO₂, SO₂, PM, and O₃ on the burden of PCOS. Utilizing restricted cubic spline regression and subgroup analysis to gain deeper insights into the association between NO₂ and PCOS.</p><p><strong>Results: </strong>Results from the mixed linear models and geographic detectors showed that NO₂, SO₂, PM, and O₃ were associated with an increased ASIR of PCOS. Meanwhile, the mixed linear models further demonstrated a positive correlation between the incidence of PCOS and the concentration of air pollutants. In further investigating the relationship between NO₂ and PCOS, we found that the associations between the concentration of NO₂ and ASIR were non-linear (P for non-linear < 0.001). Moreover, the association between NO₂ and PCOS was more pronounced in regions with middle to high economic development.</p><p><strong>Conclusions: </strong>The continuous presence and fluctuations in the concentrations of multiple air pollutants, particularly NO₂, may be potential contributors to the increasing burden of PCOS. These findings may suggest that improvements in air quality could be associated with a reduced burden of PCOS.</p>","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"198"},"PeriodicalIF":4.2,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the interplay between oxidative stress and inflammation in polycystic ovary syndrome: outcome of a case-control study.","authors":"Khurshid Ahmad Padder, Nusrat Jahan, Mohmad Aadil Yousuf, Idrees Ayoub Shah, Gulzar Ahmad Bhat, Rabia Khurshid, Mahrukh Hameed Zargar, Mohd Ashraf Ganie","doi":"10.1186/s13048-025-01734-y","DOIUrl":"https://doi.org/10.1186/s13048-025-01734-y","url":null,"abstract":"","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"196"},"PeriodicalIF":4.2,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12382036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Follicular sphericity based on three-dimensional transvaginal ultrasound algorithms predicts ovarian responsiveness to in vitro fertilization.","authors":"Jingwei Yang, Miao Wang, Danni Zhou, Hong Ye, Guoning Huang, Xuemei Lian, Xiaodong Zhang","doi":"10.1186/s13048-025-01771-7","DOIUrl":"10.1186/s13048-025-01771-7","url":null,"abstract":"<p><strong>Background: </strong>The principal indicators adopted for the assessment of follicular quality are still two-dimensional ultrasound(2D-US) imaging parameters, but these do not reflect the three-dimensional morphology of follicles. We herein aimed to explore novel parameters of ovarian follicles by three-dimensional ultrasound (3D-US) by comparing various follicles on the trigger day in gonadotropin-releasing hormone antagonist (GnRH-ant) stimulation cycles, and investigated the effects on ovarian responsiveness, oocyte and embryo quality.</p><p><strong>Methods: </strong>This was a prospective observational study of women who commenced their first controlled ovarian stimulation (COS) cycle with a GnRH-ant protocol from March 2023 to March 2024. A total of 248 patients were included in the study and 3D-US scanning was conducted on the HCG administration day. Utilizied 3D-US measurement data were then implemented to calculate follicular sphericity. Population demographics, infertility work-up, and ultrasonographic biomarkers were employed to construct models for the prediction of ovarian responsiveness and embryo quality.</p><p><strong>Results: </strong>The ROC analysis showed that the cut-off point for enabling follicular sphericity to exert a significant effect on MII oocyte was 0.716, and the patients were assigned to two groups: low sphericity(< 0.716) and high sphericity(≥ 0.716). Applying the Wilcoxon signed-rank test and the general linear model for univariate analysis and controlling for confounders, women in the low sphericity group achieved a higher oocyte retrieval rate, MII oocyte rate, follicular output rate (FORT), ovarian sensitivity index (OSI), and Day 3-8cell rate relative to women in the high sphericity group (adjusted β = 5.46, 5.15, 1.08, 2.39, 1.17, respectively; all P value < 0.05) in patients with normal ovarian reserve.</p><p><strong>Conclusion: </strong>This study was based on 3D-US measurements, follicular sphericity reliably predicted oocyte and embryo quality during in vitro fertilization monitoring in patients with normal ovarian reserve. We observed that follicular sphericity served as an available ultrasound parameter, reflecting the follicular development in COS, and providing insights for adjusting gonadotropin drug regimens.</p><p><strong>Trials registration: </strong>http://www.chictr.org.cn Identifier: ChiCTR2400085886.</p>","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"197"},"PeriodicalIF":4.2,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12382038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of tumor markers reveals EDA fibronectin as a promising target in high-grade serous ovarian cancer.","authors":"Alessia Piermattei, Roberto De Luca, Frederik Peissert, Louis Plüss, Emanuele Puca, Nicoletta D'Alessandris, Antonio Travaglino, Francesca Sillano, Tina Pasciuto, Diana Giannarelli, Gian Franco Zannoni, Anna Fagotti, Dario Neri, Giovanni Scambia, Marianna Buttarelli, Camilla Nero","doi":"10.1186/s13048-025-01772-6","DOIUrl":"https://doi.org/10.1186/s13048-025-01772-6","url":null,"abstract":"<p><strong>Background: </strong>Ovarian cancer remains a major clinical challenge with more than 40.000 annual deaths in Europe and in the United States, highlighting the need for better diagnostic and therapeutic strategies. This study first presents an immunohistochemical evaluation of the extra-domains A and B containing fibronectin (EDA-FN, EDB-FN), fibroblast activation protein (FAP), and carcinoembryonic antigen (CEA) in ovarian cancer specimens. Based on the initial results, the analysis was subsequently expanded to provide a comprehensive assessment of EDA-FN expression in human epithelial ovarian cancer tissue samples.</p><p><strong>Methods: </strong>An initial exploratory immunohistochemical analysis was performed on 60 formalin fixed paraffin embedded (FFPE) epithelial ovarian cancer (EOC) tissue sections from 47 patients, including 47 specimens collected at first diagnosis and 13 matched relapsed lesions. Tissue sections were stained using previously validated antibodies specific to EDA-FN, EDB-FN, FAP and CEA, to evaluate the stromal immunoreactive score (sIRS Part 1). Following the completion of Part 1, the study was expanded to specifically analyze the most abundant antigen found (EDA-FN) on 204 FFPE High Grade Serous ovarian cancer (HGSOC) tissue samples from 102 subjects, including primary and metastatic sites from the same patient (Part 2).</p><p><strong>Results: </strong>In Part 1, stromal expression of EDA-FN, EDB-FN and FAP was observed in epithelial ovarian cancer with no significant differences between matched primary and relapse tumor tissues. CEA was exclusively found in mucinous ovarian cancer (MOC). EDA-FN was the most abundant antigen among the ones investigated, prompting a deeper investigation in Part 2. In the expanded EOC cohort, EDA-FN remained highly abundant across all molecular subgroups (HRp, HRd/BRCAwt, and BRCAmut) and clinical subgroups (naïve vs. pretreated patients), but was found at elevated level in metastases compared to the corresponding primary tumors.</p><p><strong>Conclusions: </strong>These findings highlight that EDA-FN is an excellent target for HGSOC, while CEA could serve as a potential target for MOC. Clinical investigations are warranted to evaluate innovative treatments in ovarian cancer targeting these antigens.</p>","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"194"},"PeriodicalIF":4.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ovarian cystectomy on oncological and reproductive outcomes in borderline ovarian tumors: a retrospective study from a tertiary center.","authors":"Chujun Jiang, Yuyin Liu, Jianzhong Yu, Liying Huang, Xiaojun Yang","doi":"10.1186/s13048-025-01773-5","DOIUrl":"https://doi.org/10.1186/s13048-025-01773-5","url":null,"abstract":"<p><strong>Background: </strong>Fertility-sparing surgery (FSS) is commonly performed in patients with borderline ovarian tumors (BOT) due to their favorable prognosis. However, the long-term prognosis and pregnancy outcomes for these patients remain uncertain. This study aims to assess the feasibility of ovarian cystectomy (OC) and evaluate both oncologic and reproductive outcomes in BOT patients.</p><p><strong>Methods: </strong>A retrospective analysis of oncologic and reproductive outcomes was conducted on BOT patients who underwent OC at our department between July 1, 2007, and April 30, 2024, using univariate and multivariate analyses and survival curves.</p><p><strong>Results: </strong>Among 85 patients in the study, 12 experienced recurrence post-ovarian cystectomy. High-risk indicators included ultrasound findings, CA-125 levels, extent of surgery, and histological type. Of the 45 who attempted pregnancy, 38 conceived successfully, though no specific factors significantly influenced pregnancy outcomes. Among patients with micropapillary serous borderline ovarian tumors (MP-sBOT), 8 did not receive chemotherapy, while 6 did. Recurrence (2/8 vs. 1/6, p = 0.707) and fertility outcomes (1/8 vs. 2/6, p = 0.347) were not significantly different between those who received adjuvant chemotherapy and those who did not.</p><p><strong>Conclusions: </strong>OC is the preferred fertility-preserving treatment for BOT patients, with laparoscopic ovarian cystectomy recommended for most young, reproductive-aged patients. Early conception and close monitoring are advised for those with bilateral or high-risk tumors, though more research is needed on managing pregnancy-associated BOT.</p>","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"195"},"PeriodicalIF":4.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12382073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STAT1β modulates the tumor immune microenvironment to improve prognosis in ovarian cancer: a comprehensive study of transcriptional and protein expression differences.","authors":"Ning Lan, Xintong Li, Yifan Qiao, Siyi Zhang, Min Chen, Xiaofeng Yang, Yuliang Zou, Juan Ren, Meili Pei","doi":"10.1186/s13048-025-01780-6","DOIUrl":"https://doi.org/10.1186/s13048-025-01780-6","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;As a central regulator of the JAK/STAT signaling pathway, STAT1 generates functionally distinct α and β protein isoforms through alternative splicing. We systematically investigated the expression patterns and prognostic relevance of STAT1 isoform-specific transcripts across pan-cancer tissues, with a particular focus on ovarian cancer (OV), and elucidated their potential mechanisms in modulating the tumor immune microenvironment (TIME) to influence patient prognosis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Integrated analysis of the GTEx and TCGA databases was conducted to systematically evaluate the transcript expression profiles of STAT1 isoforms across 32 cancer types and 29 normal tissues. Clinical prognostic significance was analyzed using Cox proportional hazards regression models, complemented by multi-omics approaches including functional enrichment analysis, Tumor immune dysfunction and exclusion (TIDE) immune signature evaluation, and mediation effect models. At the experimental validation level, protein expression differences were assessed by Western blotting, while dynamic changes in immune cell infiltration were examined via immunohistochemistry (IHC) and multiplex immunofluorescence.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In the GTEx/TCGA combined dataset, the transcriptional level of the STAT1α isoform was significantly higher than that of the β isoform in most tissues. However, Western blot revealed elevated expression of the STAT1β isoform in OV tissues and cell lines-a phenomenon that may reflect isoform-specific variations in mRNA translation efficiency and/or protein stability. IHC and multiplex immunofluorescence analyses demonstrated that STAT1 expression promoted CD8&lt;sup&gt;+&lt;/sup&gt; T-cell infiltration, suppressed M2 tumor-associated macrophages (M2-TAMs), and remodeled the immune microenvironment. Multivariate Cox regression analysis identified the β isoform as an independent protective prognostic factor in OV (HR = 0.74, 95%CI: 0.55-0.99, p &lt; 0.05), and correlation analysis with TIDE immune scores showed higher absolute correlation coefficients for STAT1β. Mediation analysis indicated that STAT1β improved prognosis by reducing T-cell dysfunction (mediation: 26.53%) and inhibiting M2-TAMs infiltration (mediation: 48.07%). These effects may stem from underlying molecular mechanisms involving modulation of PD-L1/PD-1 signaling and transcriptional interference with CSF1-dependent differentiation signals.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The STAT1β isoform plays a more critical role in OV progression and immunomodulation, with its prognostic protective effect closely linked to the regulation of the immune microenvironment. These findings underscore the functional heterogeneity of STAT1 isoforms and their distinct roles in tumor immunology. Future research should prioritize the development of subtype-specific diagnostic tools and targeted therapeutic strategies to advance the development of precision immunothera","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"192"},"PeriodicalIF":4.2,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotinamide mononucleotide protects ovarian function and oocyte developmental competence during chemotherapy.","authors":"Lin Shen, Hemei Li, Xueqi Gong, Hanwang Zhang, Yiqing Zhao","doi":"10.1186/s13048-025-01782-4","DOIUrl":"https://doi.org/10.1186/s13048-025-01782-4","url":null,"abstract":"<p><strong>Background: </strong>Cyclophosphamide (CTX)-induced ovarian dysfunction and infertility represent significant concerns for reproductive-age or younger female cancer patients. Although various fertility preservation techniques are currently accessible, there remains a pressing demand for an efficient, non-invasive strategy to protect ovarian function that can be employed concurrently with chemotherapy. Considering the significance of nicotinamide adenine dinucleotide (NAD+) in regulating DNA damage and apoptosis, we aimed to examine the protective effects of nicotinamide mononucleotide (NMN, an NAD⁺ precursor) on ovarian function against CTX-induced damage.</p><p><strong>Results: </strong>Eight-week-old female C57 mice were underwent to a 14-day treatment protocol, receiving either saline, CTX, or CTX combined with NMN supplementation. The protective effects of NMN supplementation during CTX treatment on ovarian reserve, oocyte quality, and developmental competence were evaluated. NMN supplementation during CTX treatment increased NAD⁺ content in the ovary, improved ovarian reserve, enhanced endocrine function, reduced reactive oxygen species (ROS) levels, alleviated DNA damage, and reduced apoptosis. Furthermore, this supplementation improved the rates of two-cell embryo and blastocyst formation, increased total cell counts, while decreasing ROS levels, DNA damage, and apoptosis in blastocysts. Moreover, the protective mechanisms of NMN may involve key genes such as Banp and Rbm47 in the ovarian tissue, along with serum/glucocorticoid-regulated kinase 1 (Sgk1) in oocytes.</p><p><strong>Conclusions: </strong>Collectively, our results highlight the protective effects of NMN against CTX-induced damage to the reproductive function, thus addressing a critical gap in fertility preservation. We present a potential non-invasive strategy that does not interfere with cancer therapy timelines.</p>","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"193"},"PeriodicalIF":4.2,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-derived organoids as a model to study tubo-ovarian carcinoma: a pathologist's perspective.","authors":"Catarina Alves-Vale, Beatriz Galvão, Ana Rita Silvestre, José Silva Pereira, Li Bei, João Paulo Fernandes, Paula Borralho, Maria Carmo-Fonseca, Noélia Custódio","doi":"10.1186/s13048-025-01766-4","DOIUrl":"https://doi.org/10.1186/s13048-025-01766-4","url":null,"abstract":"<p><strong>Background: </strong>Tubo-ovarian carcinoma, a leading cause of gynaecological-related mortality, holds substantial biological and clinical heterogeneity. Despite advancements in drug development, predicting therapeutic efficacy remains challenging, partly due to the limited availability of in vitro models that accurately replicate tumour behaviour. We present a concise overview of the intrahospital workflow for establishing patient-derived organoids and analyse the morphological and immunophenotypical features of high-grade serous carcinoma (HGSC), serous borderline tumour (SBT)/low-grade serous carcinoma (LGSC), and normal fallopian tube (FT) organoids.</p><p><strong>Results: </strong>Samples were collected from patients undergoing surgery or paracentesis. Tissue underwent mechanical and enzymatical digestion. Resulting cell suspensions were resuspended in an extracellular matrix substitute for subsequent culture. Despite the low efficacy in establishing HGSC organoids (n = 1/7, 14%; 96 days, 11 passages), we successfully established two organoid lines of SBT/LGSC (n = 2/2, 100%; 65 days, 7 passages; 134 days, 16 passages) and normal FT (n = 2/2, 100%; 73 days, 10 passages; 58 days, 8 passages). HGSC organoids exhibited limited growth and mostly irregular structures, while preserving the p53 immunostaining pattern of the original tumour. SBT/LGSC and FT organoids maintained features of architectural complexity and faithfully recapitulated the original immunoprofile.</p><p><strong>Conclusions: </strong>This study highlights the need for a multidisciplinary collaboration in both clinical and research settings to establish patient-derived organoids. It emphasises the pivotal contribution of pathologists in meticulous sampling and organoid characterisation. The integration of diverse expertise is essential for maximising the potential of organoids as preclinical tools, advancing our understanding of tubo-ovarian carcinoma, and ultimately improving patient outcomes.</p>","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"191"},"PeriodicalIF":4.2,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12366147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of ammonium trichloride tellurate (AS101) on ovarian injury induced by chemotherapy drug doxorubicin in rats.","authors":"Yumeng Zhai, Yaoyang Zhang, Yachai Li, Min Geng, Gaoyuan Liu, Liwei Yan, Jinfang Hu, Yuanmei Deng, Jiming Chen, Zhihui Cai","doi":"10.1186/s13048-025-01709-z","DOIUrl":"10.1186/s13048-025-01709-z","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the protective effect of ammonium trichloride tellurate (AS101) on doxorubicin induced ovarian function damage in rats.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Eighteen female SD rats were randomly divided into three groups with 6 rats in each group: group A blank control group (0.9% normal saline 0.1 ml intraperitoneally for 21 consecutive days), group B (0.9% normal saline 0.1 ml intraperitoneally for 5 days, doxorubicin 10 mg / kg intraperitoneally on day 6, and continued to be injected with normal saline for 15 days), group C (0.9% normal saline 0.1 ml intraperitoneally for 5 days, doxorubicin 10 mg / kg intraperitoneally on day 6, and continued to be injected with AS101 twice every other day). The contents to be recorded by the operator team include: (1) before operation: ① observe the general state of rats in each group and record the weight of rats. ② Vaginal smears of rats in each group were observed at the same time every day to observe the estrous cycle of rats. (2) After operation: ① observe the general state of rats in each group, read the weight of rats, and record the data Vaginal smears of rats in each group were observed at the same time every day after operation to observe the estrous cycle of rats. ③ At the end of the postoperative observation period, blood samples were taken from the tail of rats to measure the serum levels of estrogen 2 (E2), follicle stimulating hormone (FSH), and anti-M ü llerian hormone (AMH). ④ At the end of the observation period, the animals were sacrificed to observe the development of bilateral ovarian follicles. ⑤ At the end of the observation period, blood was taken from the abdominal aorta of rats after anesthesia, and the upper serum was separated after centrifugation at 3000 rpm. The levels of malondialdehyde (MDA), superoxide dismutase (SOD) and reactive oxygen species (ROS) were measured according to the operation methods of the kit instructions.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Result: &lt;/strong&gt;The body weight of rats in group B was significantly lower than that in group A, while that in group C was significantly higher than that in group B (P &lt; 0.05). The estrous cycle of rats in group B was disordered, and the estrous cycle of rats in group C was restored regularly (P &lt; 0.05). The serum estradiol(E2) and AMH levels in group C were significantly higher than those in group B, and the FSH level was significantly lower than that in group B. Compared with group B, the number of primary follicles increased and the number of atretic follicles decreased in group C (P &lt; 0.05). The SOD level in group B was lower than that in group A, and that in group C was higher than that in group B (P &lt; 0.05). The levels of MDA and ROS in group B were higher than those in group A (P &lt; 0.05), while those in group C were lower than those in group B (P &lt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;AS101 can protect the damage of doxorubicin on ovarian function in rats, and its mechanism is related to i","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"190"},"PeriodicalIF":4.2,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL2RG knockout mitigates polycystic ovary syndrome pathogenesis by transitioning pyroptosis to apoptosis through the GSDME pathway.","authors":"Sailing Chen, Han Lu, Yingfen Ying, Haitao Xi, Jingyi Zheng, Chaochao Gong, Shaowei Wang, Yunbin Tang, Junzhao Zhao, Ren-Shan Ge, Xiaoheng Li","doi":"10.1186/s13048-025-01774-4","DOIUrl":"10.1186/s13048-025-01774-4","url":null,"abstract":"","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"189"},"PeriodicalIF":4.2,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}