Impact of ovarian cystectomy on oncological and reproductive outcomes in borderline ovarian tumors: a retrospective study from a tertiary center.

IF 4.2 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research Pub Date : 2025-08-26 DOI:10.1186/s13048-025-01773-5

Chujun Jiang, Yuyin Liu, Jianzhong Yu, Liying Huang, Xiaojun Yang

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Abstract

Background: Fertility-sparing surgery (FSS) is commonly performed in patients with borderline ovarian tumors (BOT) due to their favorable prognosis. However, the long-term prognosis and pregnancy outcomes for these patients remain uncertain. This study aims to assess the feasibility of ovarian cystectomy (OC) and evaluate both oncologic and reproductive outcomes in BOT patients.

Methods: A retrospective analysis of oncologic and reproductive outcomes was conducted on BOT patients who underwent OC at our department between July 1, 2007, and April 30, 2024, using univariate and multivariate analyses and survival curves.

Results: Among 85 patients in the study, 12 experienced recurrence post-ovarian cystectomy. High-risk indicators included ultrasound findings, CA-125 levels, extent of surgery, and histological type. Of the 45 who attempted pregnancy, 38 conceived successfully, though no specific factors significantly influenced pregnancy outcomes. Among patients with micropapillary serous borderline ovarian tumors (MP-sBOT), 8 did not receive chemotherapy, while 6 did. Recurrence (2/8 vs. 1/6, p = 0.707) and fertility outcomes (1/8 vs. 2/6, p = 0.347) were not significantly different between those who received adjuvant chemotherapy and those who did not.

Conclusions: OC is the preferred fertility-preserving treatment for BOT patients, with laparoscopic ovarian cystectomy recommended for most young, reproductive-aged patients. Early conception and close monitoring are advised for those with bilateral or high-risk tumors, though more research is needed on managing pregnancy-associated BOT.

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卵巢囊肿切除术对交界性卵巢肿瘤的肿瘤和生殖结局的影响：来自三级中心的回顾性研究。

背景：由于交界性卵巢肿瘤（BOT）预后良好，保留生育能力的手术（FSS）常用于患者。然而，这些患者的长期预后和妊娠结局仍不确定。本研究旨在评估卵巢囊肿切除术（OC）的可行性，并评估BOT患者的肿瘤和生殖结局。方法：回顾性分析2007年7月1日至2024年4月30日在我科行卵巢切除术的BOT患者的肿瘤和生殖结局，采用单因素和多因素分析及生存曲线分析。结果：85例患者中，12例卵巢囊肿切除术后复发。高危指标包括超声检查结果、CA-125水平、手术程度和组织学类型。在45名尝试怀孕的女性中，有38人成功怀孕，尽管没有具体的因素显著影响怀孕结果。在微乳头状浆液性交界性卵巢肿瘤（MP-sBOT）患者中，8例未接受化疗，6例接受化疗。复发率（2/8 vs 1/6, p = 0.707）和生育结果（1/8 vs 2/6, p = 0.347）在接受辅助化疗的患者和未接受辅助化疗的患者之间无显著差异。结论：卵巢切除术是BOT患者保留生育能力的首选治疗方法，大多数年轻育龄患者推荐腹腔镜卵巢囊肿切除术。对于双侧或高风险肿瘤患者，建议早期怀孕并密切监测，尽管需要更多的研究来管理与妊娠相关的BOT。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Ovarian Research REPRODUCTIVE BIOLOGY-

CiteScore

6.20

自引率

2.50%

发文量

125

审稿时长

>12 weeks

期刊介绍： Journal of Ovarian Research is an open access, peer reviewed, online journal that aims to provide a forum for high-quality basic and clinical research on ovarian function, abnormalities, and cancer. The journal focuses on research that provides new insights into ovarian functions as well as prevention and treatment of diseases afflicting the organ. Topical areas include, but are not restricted to: Ovary development, hormone secretion and regulation Follicle growth and ovulation Infertility and Polycystic ovarian syndrome Regulation of pituitary and other biological functions by ovarian hormones Ovarian cancer, its prevention, diagnosis and treatment Drug development and screening Role of stem cells in ovary development and function.