Journal of Ovarian Research最新文献

{"title":"Immediate protective effect of rUCMSC-EVs on ovarian function in a cyclophosphamide -induced premature ovarian insufficiency rats: counteracting granulosa cell apoptosis.","authors":"Zelan Yang, Cheng Zou, Yufei Deng, Hanyu Xiao, Yan Zou, Zhibiao Wang, Liaoqiong Fang, Jin Bai","doi":"10.1186/s13048-026-02119-5","DOIUrl":"https://doi.org/10.1186/s13048-026-02119-5","url":null,"abstract":"<p><strong>Backgrounds: </strong>Premature ovarian insufficiency (POI), which is defined as the loss of ovarian activity before the age of 40 leading to amenorrhea and infertility, is often induced in female patients treated with alkylating agents such as cyclophosphamide (CTX). Currently, the standard clinical management for POI is hormone replacement therapy, which alleviates symptoms but does not restore fertility. Although multiple previous studies have demonstrated that mesenchymal stem cells and their derived extracellular vesicles can protect ovarian function and restore fertility, whether concurrent EV intervention during chemotherapy can preserve ovarian reserve remains unclear.</p><p><strong>Methods: </strong>The rat umbilical cord mesenchymal stem cells derived extracellular vesicles (rUCMSC-EVs) in this study were isolated from the culture supernatant of rat umbilical cord mesenchymal stem cells (rUCMSC), and POI rat model was established via intraperitoneal injection of CTX and subcutaneous administration of busulfan. Concurrently with the chemotherapeutic drug injection, rUCMSC-EVs were injected into the ovaries. ELISA, histological assessment and mating experiments were used to evaluate ovarian function and reproductive outcomes. Additionally, ovarian granulosa cells were isolated and co-treated with CTX and rUCMSC-EVs to assess apoptosis and DNA repair capacity via flow cytometry and gene expression assays.</p><p><strong>Results: </strong>Treatment with rUCMSC-EVs effectively counteracted CTX-induced ovarian damage, as evidenced by restored ovarian weight, improved follicular reserve (increased antral follicles and reduced atreic follicles), and elevated serum anti-Müllerian hormone (AMH) and estradiol (E2) levels. Consequently, EV-treated rats exhibited reduced ovarian fibrosis and apoptosis, resulting in improved pregnancy and live birth rates. Furthermore, in ovarian granulosa cells, compared to cells treated with CTX alone, co-treatment with CTX and EVs significantly reduced apoptosis and DNA damage, while upregulating the expression levels of key DNA repair molecules (including BRCA1, BRCA2, MRE11 and RAD51).</p><p><strong>Conclusions: </strong>Our study demonstrates that the combined intervention of rUCMSC-EVs and chemotherapy drugs can alleviate the apoptosis of ovarian granulosa cells, thereby preserving the ovarian function and improving the fertility of the POI rats. The reduction in granulosa cell apoptosis may be related to the enhancement of DNA damage repair capacity.</p>","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Norepinephrine triggers ovarian granulosa cell ferroptosis via α₁ receptor-mediated FDXR suppression.","authors":"Hanqing Hong, Junyan Sun, Lichun Weng, Lin Hou, Chengqi Xiao, Qian Wang, Dongmei Lai","doi":"10.1186/s13048-026-02118-6","DOIUrl":"https://doi.org/10.1186/s13048-026-02118-6","url":null,"abstract":"","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-ovarian injection of platelet-rich plasma in patients with poor ovarian response; a randomized controlled clinical trial.","authors":"Azar Yahyaei, Tahereh Madani, Firoozeh Ahmadi, Maryam Niknejadi, Samira Vesali, Shiva Parvand, Mehri Mashayekhi","doi":"10.1186/s13048-026-02012-1","DOIUrl":"https://doi.org/10.1186/s13048-026-02012-1","url":null,"abstract":"","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The stromal microenvironment of ovary: a novel area in polycystic ovary syndrome.","authors":"Haichang Wang, Huiqin Zhou, Zhi Liu, Tiancheng Zhao, Chunping Zhang","doi":"10.1186/s13048-026-02117-7","DOIUrl":"https://doi.org/10.1186/s13048-026-02117-7","url":null,"abstract":"","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian leiomyoma revisited: a retrospective study of 18 cases with diagnostic and therapeutic implications.","authors":"Wei Qi, Zhenna Wang, Xi Xie, Jinna Zhang, Yi Wang, Zhe Xue, Guan Lin, Yan Lin, Shunhe Lin","doi":"10.1186/s13048-026-02100-2","DOIUrl":"https://doi.org/10.1186/s13048-026-02100-2","url":null,"abstract":"","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma cell-free DNA 5-hydroxymethylcytosine signatures as predictive biomarkers for platinum resistance and prognosis in epithelial ovarian cancer.","authors":"Yuan Xue, Lei Zhang, Xianglong Chen, Zhanmiao Yi, Cuiyu Huang, Ping Yu, Mengzhu Zheng, Zhanqun Yang, Hui Li, Duan Wang, Shengbo Xu, Hongyan Guo, Libo Zhao, Jian Lin, Long Chen","doi":"10.1186/s13048-026-02113-x","DOIUrl":"https://doi.org/10.1186/s13048-026-02113-x","url":null,"abstract":"","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemoresistance in gynecologic cancers: mechanistic insights and emerging platforms to overcome drug failure.","authors":"Pankaj Garg, Ravi Salgia, Sharad S Singhal","doi":"10.1186/s13048-026-02115-9","DOIUrl":"https://doi.org/10.1186/s13048-026-02115-9","url":null,"abstract":"","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"19 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The immunogenetic basis of ovarian apoptosis: from TNF-α polymorphisms and signaling pathways to glucocorticoid-mediated rescue.","authors":"Farzaneh Motafeghi, Parham Mortazavi, Nasrin Ghassemi Barghi","doi":"10.1186/s13048-026-02112-y","DOIUrl":"https://doi.org/10.1186/s13048-026-02112-y","url":null,"abstract":"","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic changes in homologous recombination status before and after chemotherapy in advanced ovarian, fallopian tube, and primary peritoneal cancers.","authors":"Akemi Morimoto, Takashi Matsumoto, Norifumi Teramoto, Sakiko Murakami, Tomoka Usami, Junko Murai, Takashi Sugiyama","doi":"10.1186/s13048-026-02101-1","DOIUrl":"https://doi.org/10.1186/s13048-026-02101-1","url":null,"abstract":"","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness analysis of nab-paclitaxel with or without relacorilant for platinum-resistant ovarian cancer.","authors":"Shubin Lai, Shufei Lai, Xiaoxin Xu, Wenhui Huang, Qiuhong Chen, Suling He, Honglin Xue","doi":"10.1186/s13048-026-02109-7","DOIUrl":"https://doi.org/10.1186/s13048-026-02109-7","url":null,"abstract":"","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}