Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Intrathecal Chemotherapy Through Ommaya Reservoir in Leptomeningeal Metastasis From Cervical Cancer: A Rare Case Report and Literature Review","authors":"Chery Ahn,&nbsp;Haein Seo,&nbsp;Dongmin Jo,&nbsp;Byeol Han,&nbsp;Eunmi Choi,&nbsp;Sewon Kim,&nbsp;Seo Woo Chung,&nbsp;Ok-Ju Kang","doi":"10.1111/jog.70490","DOIUrl":"10.1111/jog.70490","url":null,"abstract":"<p>Leptomeningeal metastasis (LM) is a rare complication of cervical cancer associated with a poor prognosis. We report a 61-year-old woman with stage IVB cervical squamous cell carcinoma who developed acute headache and diplopia during systemic chemotherapy. Brain magnetic resonance imaging suggested LM, which was confirmed by cerebrospinal fluid (CSF) cytology. An Ommaya reservoir was inserted, and intrathecal methotrexate therapy was initiated. The patient showed rapid neurological improvement, normalization of CSF opening pressure, and sustained clearance of malignant cells on serial CSF cytology. Although systemic disease subsequently progressed, LM-related neurological symptoms remained well controlled. The patient survived for 8 months after LM diagnosis. This case highlights the importance of considering LM in cervical cancer patients with new neurological symptoms and suggests that intrathecal chemotherapy via an Ommaya reservoir may provide effective neurological control and symptomatic relief.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 9","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Course and Clinical Characteristics of Severe Cerebral Palsy Associated With Perinatal Cerebral Infarction: A Nationwide Registry-Based Study in Japan","authors":"Manabu Ogoyama,&nbsp;Hironori Takahashi,&nbsp;Kenji Horie,&nbsp;Hirotada Suzuki,&nbsp;Akihide Ohkuchi,&nbsp;Hiroyuki Fujiwara","doi":"10.1111/jog.70491","DOIUrl":"10.1111/jog.70491","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To clarify the clinical characteristics, diagnostic course, and presumed etiologies of severe cerebral palsy associated with perinatal cerebral infarction, and to compare cases in which cerebral infarction was diagnosed during and after the neonatal period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective registry-based study used data from the Japan Obstetric Compensation System for Cerebral Palsy between 2009 and 2022. Severe cerebral palsy cases associated with cerebral infarction were identified. The clinical characteristics and diagnostic courses of cerebral infarction were evaluated and compared between neonatally diagnosed cases and post-neonatally diagnosed cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 85 cases of cerebral infarction analyzed, neonatally diagnosed cases accounted for 40 (47.1%) and post-neonatally diagnosed cases for 44 (51.8%); 1 case was diagnosed prenatally. Neonatal diagnosis was more frequently triggered by seizures, apnea, respiratory distress, or neuroimaging during NICU hospitalization, whereas most post-neonatal diagnoses followed recognition of motor impairment. Neonatally diagnosed cases more frequently exhibited a non-reassuring fetal status, lower umbilical artery pH, lower Apgar scores, and neonatal asphyxia. However, no significant differences were observed in median age at the recognition of motor impairment (7 months in both groups) or severe brain injury findings between neonatally and post-neonatally diagnosed cases. Potential contributing conditions were identified in 15.3% of cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Similar timing of motor impairment recognition and frequency of severe brain injury findings between the two groups may suggest that differences in cerebral infarction diagnostic timing may primarily reflect different clinical triggers for neuroimaging. The etiology and timing of infarction onset remained unclear in many cases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 9","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Markedly Elevated sFlt-1/PlGF Ratios in Atypical Superimposed Preeclampsia Before 20 Weeks of Gestation: A Three-Case Series","authors":"Chisa Ito,&nbsp;Manabu Ogoyama,&nbsp;Akihide Ohkuchi,&nbsp;Hirotada Suzuki,&nbsp;Hironori Takahashi,&nbsp;Hiroyuki Fujiwara","doi":"10.1111/jog.70492","DOIUrl":"10.1111/jog.70492","url":null,"abstract":"<div>\u0000 \u0000 <p>Atypical superimposed preeclampsia (sPE) developing before 20 weeks of gestation is extremely rare, and its pathophysiology remains unclear. We herein report three women with underlying chronic hypertension or IgA nephropathy who developed severe hypertension, worsening proteinuria, and fetal growth restriction or fetal death before 20 weeks of gestation. All cases showed markedly elevated soluble fms-like tyrosine kinase-1/placental growth factor (sFlt-1/PlGF) ratios (617–1357), and placental pathology demonstrated maternal vascular malperfusion. Maternal clinical manifestations promptly improved after the termination of pregnancy. All three women subsequently achieved successful pregnancies with appropriate management. These results suggest that atypical sPE shares the angiogenic imbalance and placental pathology characteristic of conventional preeclampsia. Although limited by the small number of cases, these results provide additional insights into the pathophysiology of atypical sPE and suggest a role for angiogenic biomarkers in evaluating placental dysfunction.</p>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 9","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Landscape of Women's Health Podcasts: A Scoping Review","authors":"Ellen Beatriz Saboia de Castro,&nbsp;Janielle Ferreira de Brito Lima,&nbsp;Kayo Elmano Costa da Ponte Galvão,&nbsp;Eremita Val Rafael,&nbsp;William Caracas Moreira,&nbsp;Roger Rodrigues da Silva,&nbsp;Mônica Oliveira Batista Oriá,&nbsp;Maria Luziene de Sousa Gomes","doi":"10.1111/jog.70483","DOIUrl":"10.1111/jog.70483","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To map and characterize the available evidence on podcasts addressing topics related to women's health.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This scoping review was conducted in accordance with the Joanna Briggs Institute (JBI) guidelines. A comprehensive search was carried out in 12 databases in November 2025. Quantitative and qualitative studies addressing podcasts related to women's health were included, with no restrictions on publication date or language. The review protocol was registered on the Open Science Framework (https://osf.io/7p9yr/overview). The results are reported in accordance with the PRISMA extension for Scoping Reviews (PRISMA-ScR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 37 studies were included, primarily targeting health professionals and students (<i>n</i> = 15). Thematic analysis showed that gynecology was the most frequent category (48.6%), with subthemes focusing on the climacteric (<i>n</i> = 6), breast cancer (<i>n</i> = 4), and fertility (<i>n</i> = 3). Breastfeeding and healthy lifestyle shared second place (18.9% each), emphasizing lactation challenges and physical activity/nutrition, respectively. Obstetrics (13.5%) addressed labor and postpartum recovery, while motherhood (8.1%) explored maternal guilt. Finally, miscellaneous themes (16.2%) covered mental health, chronic diseases, and maternal mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Podcasts have emerged as a versatile and strategic tool for health education and self-care promotion throughout the female life cycle. While widely used for professional training and patient empowerment, there is a critical need for rigorous content curation and evidence-based production to mitigate the risks of misinformation. Future research should focus on validating these digital tools and evaluating their long-term impact on clinical outcomes and health literacy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 9","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13533598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA Methylation Testing in Cervical Cancer: A Triage Tool for HPV-Based Screening and Post-Treatment Surveillance","authors":"Yuance Xu,&nbsp;Xiaoting Zhou,&nbsp;Lina Guo,&nbsp;Rongjun Lyu","doi":"10.1111/jog.70473","DOIUrl":"10.1111/jog.70473","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>High-risk HPV screening achieves high sensitivity but low specificity, resulting in excessive colposcopy referrals. DNA methylation biomarkers could refine risk stratification across the cervical cancer care continuum.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the diagnostic performance and clinical implementation of DNA methylation testing in HPV-positive triage and post-treatment surveillance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Narrative review of prospective cohorts and randomized trials (2013–2024) evaluating methylation markers in cervical cancer screening and monitoring.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The FAM19A4/miR124-2 panel demonstrated sensitivity/specificity of 0.83/0.90 for CIN3+ in HPV-positive women, reducing colposcopy referrals by 45% while maintaining &lt; 3% missed CIN3+. In post-treatment surveillance, plasma cell-free DNA (cfDNA) methylation may enable earlier recurrence detection than imaging (sensitivity 0.81, specificity 0.93, based on limited prospective data). A proposed three-step conceptual framework integrating methylation testing across screening, postoperative assessment, and recurrence monitoring is presented as a hypothesis-generating model requiring prospective validation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>DNA methylation testing shows promise for clinical implementation in HPV triage and post-treatment surveillance. Evidence remains fragmented across separate studies. Standardization of thresholds and cost reduction are priorities for guideline inclusion.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 9","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Exercise on Reproductive and Metabolic Outcomes in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis","authors":"Kangxi Zou,&nbsp;Yunlu Ping,&nbsp;Qiuyang Wei,&nbsp;Xiaoxuan Zhao,&nbsp;Ying Wang,&nbsp;Di Wu,&nbsp;Lu Chen,&nbsp;Shimeng Wang,&nbsp;Xiaoling Feng","doi":"10.1111/jog.70477","DOIUrl":"10.1111/jog.70477","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder, and the independent effect of exercise as a fundamental intervention for it remains to be clarified. Therefore, this study aimed to examine the effect of exercise intervention alone on improving reproductive endocrine and metabolic profiles in individuals with PCOS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic search of multiple databases was conducted for randomized controlled trials (RCTs) published until July 2025. Data from eligible RCTs were collected, and quality evaluation with meta-analysis was performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This investigation encompassed 22 RCTs involving 1044 women with PCOS. The meta-analysis indicated that exercise significantly reduced total testosterone (TT), free testosterone, fasting insulin, and homeostatic model assessment of insulin resistance (HOMA-IR), while increasing high-density lipoprotein levels. Subgroup analyses showed that moderate-to-low intensity exercise specifically increased sex hormone-binding globulin. Exercise duration ≥ 150 min per week yielded more pronounced reductions in TT. Concerning population characteristics, Asian cohorts exhibited particularly prominent improvements in reducing body mass index, TT, low-density lipoprotein, fasting insulin, and HOMA-IR. South American and European populations showed significant benefits in lowering TT and fasting insulin, respectively. Moreover, non-obese women with PCOS experienced greater reductions in TT compared to their obese counterparts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Exercise intervention alone significantly ameliorates body composition, hyperandrogenism, and certain glucose and lipid metabolic disturbances in individuals with PCOS. The benefits are modulated by exercise parameters (intensity, weekly duration) and baseline patient characteristics (geographical distribution, obesity status), highlighting the importance of individualized interventions in clinical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 9","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Point-of-Care Fibrinogen Testing and Hemorrhage Outcomes in Severe Postpartum Hemorrhage: An Interrupted Time Series Analysis","authors":"Eishin Nakamura,&nbsp;Shigetaka Matsunaga,&nbsp;Akihiko Kikuchi,&nbsp;Yasushi Takai","doi":"10.1111/jog.70482","DOIUrl":"10.1111/jog.70482","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Increasingly, point-of-care testing has been adopted to rapidly assess fibrinogen levels for managing severe postpartum hemorrhage; however, evidence regarding its impact on clinical outcomes is limited. We evaluated whether implementing a transfusion strategy guided by point-of-care testing was associated with changes in blood loss and transfusion outcomes in patients with severe postpartum hemorrhage.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective single-center interrupted time series analysis at a tertiary perinatal referral center in Japan. Consecutive patients with severe postpartum hemorrhage (blood loss, ≥ 1000 mL) requiring emergency transfer between April 2014 and March 2019 were included. A dry hematology–based point-of-care testing system combined with a standardized transfusion protocol was introduced in March 2016. The primary outcome was total blood loss. Secondary outcomes included transfusion volumes and in-hospital maternal mortality. Segmented regression models were used to estimate changes in level and trend before and after implementation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 142 patients included (52 before and 90 after intervention implementation), baseline severity indicators were higher in the pre-intervention period. Implementation of the point-of-care testing–guided transfusion strategy was not associated with significant changes in total blood loss or volumes of red blood cells or fresh frozen plasma transfused. Similar findings were observed for in-hospital outcomes. Results were consistent across the adjusted and sensitivity analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Implementing a point-of-care testing–guided transfusion strategy was not associated with significant improvements in blood loss or transfusion outcomes among patients with severe postpartum hemorrhage at our tertiary referral center. These findings should be interpreted within the context of this institutional setting and do not exclude the possibility that point-of-care testing may provide clinical benefit in other patient populations or healthcare settings. Further studies are needed to identify the clinical settings in which point-of-care testing–guided transfusion strategies are most effective.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 9","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal Changes in Serum Fibroblast Growth Factor 21 and Their Association With Postpartum Insulin Resistance in Women With Gestational Diabetes Mellitus.","authors":"Yosuke Suzuki, Akihito Morita, Jun Okaniwa, Ayuko Tanaka, Yuko Hasegawa, Tatsuya Sato, Daisuke Higeta, Akira Iwase","doi":"10.1111/jog.70480","DOIUrl":"10.1111/jog.70480","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to clarify the clinical significance of perinatal changes in fibroblast growth factor 21 and their association with postpartum metabolic outcomes in women with gestational diabetes mellitus.</p><p><strong>Methods: </strong>This single-center retrospective observational study used prospectively collected residual serum samples to investigate longitudinal changes in serum fibroblast growth factor 21 concentrations at approximately 26 (T1) and 36 (T2) weeks of gestation and within 7 days postpartum (T3) in 45 women with gestational diabetes mellitus and 30 controls. Associations between fibroblast growth factor 21 concentrations and postpartum metabolic outcomes were evaluated in the gestational diabetes mellitus group.</p><p><strong>Results: </strong>Serum fibroblast growth factor 21 concentrations increased significantly from T1 to T2 and remained elevated at T3, irrespective of gestational diabetes mellitus status, as assessed using the Friedman test with post hoc comparisons. In women with gestational diabetes mellitus, fibroblast growth factor 21 showed predictive performance for postpartum insulin resistance, as assessed using the homeostasis model assessment of insulin resistance. Receiver operating characteristic analysis showed the highest area under the curve for predicting postpartum insulin resistance at T1 (area under the curve, 0.871; bootstrap 95% confidence interval, 0.732-0.973). Fibroblast growth factor 21 concentrations appeared to decline during the early postpartum period, as indicated by significantly lower T3/T1 ratios in samples from postpartum Days 5-7 compared with those from Days 1-4.</p><p><strong>Conclusions: </strong>These findings suggest that perinatal fibroblast growth factor 21 dynamics may reflect physiological changes in insulin sensitivity and that fibroblast growth factor 21 concentrations measured during pregnancy may serve as a complementary indicator for postpartum metabolic risk stratification in women with gestational diabetes mellitus. Further validation is needed before clinical application.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 9","pages":"e70480"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Hysterectomy for Postpartum Hemorrhage in Japan: Diagnostic Code Validation and Nationwide Descriptive Analysis\".","authors":"","doi":"10.1111/jog.70475","DOIUrl":"10.1111/jog.70475","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 9","pages":"e70475"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Application of a Psychological Expectations Scale for Patients With Middle- and Late-Stage Cervical Cancer in China.","authors":"Huaiming Zhang, Aonan Liu, Rong Zhang, Yufeng Wang","doi":"10.1111/jog.70481","DOIUrl":"10.1111/jog.70481","url":null,"abstract":"<p><strong>Objective: </strong>The Psychological Expectation Scale for Patients with Middle- and Late-Stage Cervical Cancer (PES-PMLSCC) was developed to assess the psychological expectations of patients with middle and late cervical cancer, and its reliability, validity, and acceptability were tested.</p><p><strong>Method: </strong>Employing classical test theory methodology, a cohort of 148 cervical cancer patients classified as FIGO Stage III or IV (or equivalent TNM staging) was enrolled in this study. The PES-PMLSCC scale was developed. The initial iteration of the PES-PMLSCC was refined through item analysis. To assess the structural validity of the final scale, exploratory factor analysis (EFA) was conducted, followed by preliminary internal validation using confirmatory factor analysis (CFA) and structural equation modeling (SEM). The criterion-related validity (CRV) of the final PES-PMLSCC version was evaluated by calculating the Pearson correlation coefficient between the PES-PMLSCC and the QLQ-C30.</p><p><strong>Results: </strong>The PES-PMLSCC scale comprises 14 items distributed across four subscales: physiological needs (three items), safety needs (four items), social needs (two items), and self-actualization (five items). Preliminary evidence of reliability, as indicated by a Cronbach's alpha of 0.819, a Spearman-Brown coefficient of 0.912, and a test-retest reliability coefficient of 0.928. The preliminary internal validation of the validity showed that χ²/df = 1.39, GFI = 0.93, CFI = 0.98, NFI = 0.93, IFI = 0.98, TLI = 0.97, RMSEA = 0.05, and the I-CVIs exceeded 0.80.</p><p><strong>Conclusions: </strong>The findings indicate that the PES-PMLSCC is applicable for assessing the level of psychological expectations among patients with middle- and late-stage cervical cancer in China, particularly in the southwestern region.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 9","pages":"e70481"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}