Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Successful treatment of chylous leakage with delayed presentation after endometrial cancer surgery using dietary therapy, octreotide, and computed tomography-guided lymphangiography: A case report and literature review","authors":"Takayuki Takahashi,&nbsp;Iori Kisu,&nbsp;Shunki Kiyokawa,&nbsp;Mayuka Anko,&nbsp;Haruko Ohno,&nbsp;Teppei Okamura,&nbsp;Nobumaru Hirao","doi":"10.1111/jog.70066","DOIUrl":"10.1111/jog.70066","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Chylous ascites (CA) is a rare yet clinically significant complication following gynecologic cancer surgery, with incidence rates of 0.17 % to 9%. We aimed to describe a case of CA with a delayed clinical presentation nearly 100 days postoperatively in a patient with advanced endometrial cancer and to review the management strategies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively evaluated a 75-year-old patient who underwent radical hysterectomy, bilateral salpingo-oophorectomy, extended lymphadenectomy (pelvic and para-aortic), and partial omentectomy for stage IIIB endometrial cancer. Data collected included onset timing, ascitic fluid analysis, imaging findings, and treatment responses. Additionally, a narrative review identified 13 relevant studies discussing the onset, risk factors, diagnosis, and therapies for post-operative CA in gynecologic oncology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Although CA typically appears within 4 to 21 days, our patient developed CA at approximately post-operative day 99. Diagnostic paracentesis confirmed triglyceride-rich ascitic fluid, establishing the diagnosis of CA. Dietary modification (fasting followed by medium-chain triglyceride diet), octreotide therapy, and computed tomography (CT)-guided lymphangiography effectively controlled the chylous leakage without requiring surgery.</p>\u0000 \u0000 <p>Conservative measures—low-fat or medium-chain triglyceride diets, total parenteral nutrition, and somatostatin analogs—are considered first-line, while lymphangiography/embolization and eventual surgical ligation may be needed for refractory cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This case illustrates that CA with a delayed clinical presentation can be successfully treated with a stepwise conservative approach comprising dietary therapy, octreotide, and CT-guided lymphangiography, even when presenting more than 3 months postoperatively. Moreover, our patient remained free of disease recurrence at 1 year and 8 months postoperatively, underscoring that timely management of CA can avoid delays in adjuvant therapy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 9","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.70066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of androgens on pregnancy and fetal outcomes in patients with polycystic ovary syndrome","authors":"Ömer Tammo,&nbsp;Esra Söylemez,&nbsp;Yusuf Ziya Kızıldemir,&nbsp;Mehmet İncebıyık,&nbsp;Muhammet Erdal Sak","doi":"10.1111/jog.70056","DOIUrl":"10.1111/jog.70056","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting approximately 20% of women of reproductive age. The impact of high androgen levels on pregnancy and fetal outcomes is complex and multifaceted, largely due to the heterogeneous nature of PCOS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This prospective cohort study included 65 pregnant women diagnosed with PCOS (using the Rotterdam criteria) and 65 age-matched healthy pregnant controls at Harran University Hospital. Blood samples were collected at 18–19 weeks of gestation to quantify testosterone and sex hormone-binding globulin (SHBG) levels, and the free androgen index (FAI) was calculated. Demographic and clinical data were recorded, and obstetric complications and birth outcomes were analyzed, adjusting for potential confounding factors using multivariate analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Pregnant women with PCOS exhibited lower parity (1.8 ± 1.0 vs. 2.2 ± 1.3, <i>p</i> = 0.033), lower birth weight (2827.0 ± 579.3 g vs. 3059.1 ± 561.2 g, <i>p</i> = 0.022), and lower SHBG levels (67.8 ± 58.8 nmol/L vs. 125.3 ± 36.8 nmol/L, <i>p</i> &lt;0.001). Conversely, they demonstrated higher BMI (31.1 ± 6.1 vs. 27.6 ± 5.1, <i>p</i> = 0.001), total testosterone (32.6 ± 14.1 vs. 26.1 ± 8.1, <i>p</i> = 0.009), and FAI levels (136.9 ± 128.2 vs. 31.2 ± 39.4, <i>p</i> &lt;0.001). The incidence of complications such as intrauterine growth retardation (IUGR) and small for gestational age (SGA) was higher in the PCOS group, while the healthy birth rate was lower. The incidence of preeclampsia was also higher in the PCOS group. In the PCOS group, the FAI demonstrated a negative correlation with gestational week and birth weight (<i>r</i> = −0.376, <i>p</i> = 0.002), indicating that as these values increased, the FAI exhibited a corresponding decrease.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study demonstrates the adverse effects of hyperandrogenism on pregnancy and fetal development in women with PCOS, highlighting the clinical significance of this condition. Further research is required to elucidate the underlying mechanisms of hyperandrogenism and to identify effective strategies to improve pregnancy outcomes in women with PCOS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 9","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transvaginal mesh surgery for pelvic organ prolapse without blind maneuver: Follow-up of 1 year or longer","authors":"Kikuo Okamura,&nbsp;Kensuke Yoshizawa,&nbsp;Hideji Kawanishi,&nbsp;Yudai Miyata,&nbsp;Junko Tanaka,&nbsp;Yasushi Yoshino","doi":"10.1111/jog.70051","DOIUrl":"10.1111/jog.70051","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To present surgical outcomes of transvaginal mesh surgery for pelvic organ prolapse (POP) without the blind maneuver, followed up 1 year or more.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included 140 consecutive women with a mean age of 77.6 years. We investigated surgical outcomes, including early and late complications and recurrence. Furthermore, we studied risk factors for recurrence and mesh extrusion using uni- and multivariate analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Surgery required 120 ± 21 min, with blood loss of 58 ± 63 g. Minor injuries of the bladder and rectum occurred in six and two patients, respectively. The urethral catheter was removed on postoperative day 1.2, and patients were discharged on postoperative day 4. There was no case of voiding dysfunction requiring catheterization. Wound infections occurred in four patients; but they subsided with only peroral antibiotics. Twenty-five patients had anatomical recurrences; of those, nine underwent additional surgery. Mesh extrusion occurred in six patients; the extruded part was excised in all patients. Eleven patients underwent transvaginal tape surgery for subsequent stress urinary incontinence. Logistic regression analyses indicated that risk factors for recurrence were prolapse stage and uterine status, and that for mesh extrusion was uterine status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Although recurrence and mesh-related problems could occur especially in patients with a higher stage of prolapse and/or a history of hysterectomy, it is considered that our technique is safe and effective to treat women with POP. However, we need to identify other, more appropriate techniques for patients with severe prolapse and/or a history of hysterectomy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 9","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical analysis of the effect of embryonic outcomes in carriers of chromosomal translocations from different parental sources: A retrospective cohort study of 178 couples","authors":"Yarong Guo,&nbsp;Xinhai Liu,&nbsp;Zehui Xie,&nbsp;Xiaoling Ma","doi":"10.1111/jog.70044","DOIUrl":"10.1111/jog.70044","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the impact of parental origin (paternal vs. maternal) on embryonic developmental potential and clinical outcomes in carriers of balanced chromosomal translocations; to provide evidence for sex-specific genetic counseling.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Study Design</h3>\u0000 \u0000 <p>A total of 178 couples undergoing preimplantation genetic testing for structural rearangement treatment for balanced chromosomal translocations at the Center for Reproductive Medicine, First Hospital of Lanzhou University, between January 2019 and December 2022 were retrospectively included. They were stratified into paternal translocation (<i>n</i> = 75) and maternal translocation (<i>n</i> = 103) groups based on parental origin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>(1) Sperm quality parameters (progressive motility, immotile sperm, and normal morphology rate) were significantly lower in paternal translocation carriers compared to maternal translocation carriers. (2) Paternal translocation carriers demonstrated significantly higher blastocyst formation rates (59.82% vs. 52.35%, <i>p</i> = 0.006) and high-quality blastocyst rates (38.61% vs. 31.07%, <i>p</i> = 0.034) than maternal translocation carriers. (3) The transferable embryo rate was significantly lower in the maternal translocation group than in the paternal group (<i>p</i> = 0.004). Among abnormal embryos, the maternal group exhibited higher rates of both parental-origin abnormalities (<i>p</i> = 0.012) and complex abnormalities (<i>p</i> = 0.021) compared to the paternal group. (4) The 2:2 alternate segregation rate was significantly higher in the paternal translocation group than in the maternal group (29.67% vs. 39.83%, <i>p</i> = 0.002). Conversely, the 3:1 segregation rate was significantly higher in the maternal translocation group than in the paternal group (26.33% vs. 17.35%, <i>p</i> = 0.002).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Embryos derived from paternal translocation carriers demonstrated significantly higher developmental potential than those from maternal carriers. The elevated rate of de novo chromosomal abnormalities in embryos of maternal translocation carriers underscores the necessity for genetic counseling that differentiates between translocation-associated and incidental genetic anomalies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144905659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of boric acid on ovarian damage caused by endotoxaemia","authors":"Melek Aydin,&nbsp;Nebahat Çağlayan,&nbsp;Özlem Kara,&nbsp;Mustafa Kara","doi":"10.1111/jog.70055","DOIUrl":"10.1111/jog.70055","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Sepsis is a serious reaction of the whole body to an infection that develops in the presence of bacteria or toxins in the body. Boric acid (BA) is the most common mineral acid among boron compounds and is easily soluble in water. BA has antioxidant and anti-inflammatory properties. In line with this information, in our study, the protective effect of BA was examined by creating sepsis with lipopolysaccharide (LPS), a bacterial endotoxin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In our study, 32 Wistar Albino female rats were used and divided into four groups. The protective effect of BA on ovarian histopathology and ovarian functions as a result of endotoxaemia was investigated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>As a result of the examinations, follicle counts were evaluated in the groups. As a result, it was found that fibrosis occurred in the cortex vessels in the ovary of rats given LPS, follicle loss occurred, and ovarian tissue scarring caused toxicity on primordial follicles. The number of primordial follicles in the LPS group was significantly lower than in the BA + LPS group (<i>p</i> &lt; 0.05). Contrary to this, the number of atretic follicles was found to be significantly higher in the LPS group than in the BA + LPS group (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In this study, it was concluded that BA had a protective effect on the ovarian damage caused by endotoxaemia induced by LPS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considering its mechanism of action it may be logical to choose letrozole as an initial option for endometrium preparation before vitrified-warmed embryo transfer","authors":"Gercek Aydin,&nbsp;Kiper Aslan,&nbsp;Merve Arac,&nbsp;Elif Ergin,&nbsp;Isil Kasapoglu,&nbsp;Gurkan Uncu","doi":"10.1111/jog.70048","DOIUrl":"10.1111/jog.70048","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To assess the efficacy of letrozole and programmed hormone replacement therapy (HRT) cycles in terms of obstetric outcomes for women undergoing a single vitrified-warmed blastocyst embryo transfer (SVBT).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study is a retrospective study conducted in a private IVF (in vitro fertilization) clinic. A total of 324 FET cycles (letrozole group = 183, HRT = 141), consisting of primary infertile patients aged &lt;40 years, were enrolled. The cycle characteristics, pregnancy results, and perinatal parameters were recorded. The primary outcomes of this study are pregnancy and miscarriage rates, live birth rates, whereas hypertensive disease of pregnancy (HDP), intrauterine growth restriction (IUGR) and preterm birth are the secondary outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Positive β-HCG rates were 53% (97/183) versus 61% (86/141), whereas clinical pregnancy rates were 47% (86/183) versus 51.1% (72/141) for the letrozole and HRT groups, respectively. For clinical miscarriage, the results were 6.5% (12/183) for letrozole versus 15.6% (22/141) for HRT groups, which were statistically significant. For live birth rate (LBR), letrozole was found to be slightly better compared to HRT 40.4% (74/183) versus 35.5% (50/141). Considering the perinatal outcomes, the parameters were comparable between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In terms of perinatal outcomes and IVF success, letrozole was not found to be inferior to HRT. Letrozole can be utilized as a safe and effective agent, even as a first-line treatment, given the potential benefits offered by its mechanism of action and being a reasonable option for both ovulatory and unovulatory patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometrial thickness as a predictor of methotrexate treatment success in ectopic pregnancy: A prospective cohort study","authors":"Shima Hoseini,&nbsp;Sara Ashtari,&nbsp;Mohammad Mahdi Mehrabi,&nbsp;Nafiseh Saedi,&nbsp;Zahra Rezaei","doi":"10.1111/jog.70043","DOIUrl":"10.1111/jog.70043","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Ectopic pregnancy (EP) remains a significant cause of first-trimester maternal morbidity and mortality. Methotrexate (MTX) is an effective non-surgical treatment for selected early pregnancy cases; however, predicting treatment success remains challenging. Endometrial thickness (ET) has been suggested as a potential predictor, though its clinical utility remains uncertain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this prospective cohort study, 86 women with diagnosed tubal EP and stable hemodynamic status received a single intramuscular dose of MTX (50 mg/m²). Endometrial thickness was measured via transvaginal sonography. Treatment success was defined as a &gt;15% decline in serum β-hCG between days 4 and 7 post-MTX without the need for a second dose or surgery. Logistic regression and ROC analysis were conducted to evaluate predictors of treatment success.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Treatment was successful in 57% of patients. Responders had significantly thinner endometria (mean ET: 8.09 ± 3.53 mm) compared to non-responders (11.54 ± 4.07 mm, <i>p</i> &lt; 0.001). An ET cut-off of 9.5 mm predicted treatment success with 73% sensitivity and 69.6% specificity (AUC = 0.740, <i>p</i> &lt; 0.001). Mass size was also a significant independent predictor, while initial β-hCG and yolk sac presence were not.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Endometrial thickness is a significant predictor of MTX treatment success in unruptured EP. An ET ≤9.5 mm is associated with a higher likelihood of response. ET measurement may aid clinicians in selecting patients and developing effective management strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the 2023 FIGO staging system and its concordance with the JSGO guidelines in endometrial cancer: A multi-institutional retrospective study in Japan","authors":"Takatoshi Manabe,&nbsp;Hiroko Machida,&nbsp;Taichi Mizushima,&nbsp;Shinichi Endo,&nbsp;Jun Takeuchi,&nbsp;Koji Matsuo,&nbsp;Miwa Yasaka,&nbsp;Hiroshi Kajiwara,&nbsp;Satoshi Fujii,&nbsp;Mayu Nakagawa,&nbsp;Junki Koike,&nbsp;Motohiro Chosokabe,&nbsp;Etsuko Miyagi,&nbsp;Kazuyoshi Kato,&nbsp;Nao Suzuki,&nbsp;Mikio Mikami","doi":"10.1111/jog.70049","DOIUrl":"10.1111/jog.70049","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To validate the prognostic accuracy of the 2023 FIGO staging system and assess its alignment with the Japan Society of Gynecologic Oncology (JSGO) guidelines for endometrial cancer treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study included 1207 patients with endometrial cancer treated at four academic hospitals in Kanagawa, Japan, between 2018 and 2022. Patients were reclassified according to the FIGO 2023 system and the JSGO recurrence risk categories. Primary endpoints included stage migration, recurrence risk (RR), overall survival (OS), and concordance between the two classification systems.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Under FIGO 2023, the stage distribution was: I, 741 (61.4%); II, 203 (16.8%); III, 149 (12.3%); and IV, 114 (9.4%), with stage migration observed in 36.3% of cases. The FIGO 2023 system provided clearer stratification of 3-year RR than FIGO 2009, with the RR gap widening from 80.0% to 90.1%. Sixteen patients (3.5%) with stage IA3 were classified as high risk by JSGO criteria, while 14.4% of patients considered high risk by JSGO were downstaged under FIGO 2023. Additionally, 46 patients (19.6%) with FIGO stage IA were reclassified as intermediate risk owing to focal lymphovascular space invasion (LVSI). Substantial LVSI was significantly associated with recurrence and poor prognosis (3-year OS rates: none 94.3%, focal 89.9%, and substantial 40.7%; <i>p</i> &lt; 0.05). Molecular testing was limited: p53 in 30.2%, MSI in 5.9%, and POLE was not available.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>FIGO 2023 improves prognostic precision. Incorporating LVSI extent and molecular data may refine JSGO classifications and support more individualized adjuvant therapy strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptomatic and asymptomatic venous thromboembolism after minimally invasive surgery for gynecological cancers","authors":"Michiko Kubo-Kaneda,&nbsp;Hanano Hirota,&nbsp;Saki Kotaka,&nbsp;Asumi Okumura,&nbsp;Tsuyoshi Mastumoto,&nbsp;Kota Okamoto,&nbsp;Masafumi Nii,&nbsp;Kenta Yoshida,&nbsp;Kuniaki Toriyabe,&nbsp;Eiji Kondo","doi":"10.1111/jog.70054","DOIUrl":"10.1111/jog.70054","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To clarify the frequency of postoperative symptomatic and asymptomatic venous thromboembolism (VTE) in patients who underwent minimally invasive surgery (MIS) for gynecological cancers; and to identify the risk factors associated with pulmonary embolism (PE).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed data for patients with endometrial, cervical, or ovarian cancers who underwent MIS or open surgery between February 2012 and December 2021 at Mie University Hospital, Japan. Patients who required conversion to open surgery were excluded. We treated deep vein thrombosis (DVT), including distal DVT, with preoperative anticoagulation. In all cases, intra- and postoperative VTE prophylaxis with anticoagulation, intermittent pneumatic compression, and compression stockings were provided.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 382 patients with gynecological cancers who underwent MIS were included. Approximately 90% of patients had stage I disease. Symptomatic and asymptomatic PE occurred in 0.2% and 1.5% of patients who underwent MIS, respectively. All patients who developed PE had DVT. In the MIS group, both DVT and PE occurred in seven cases each (1.8%). Conversely, in the open surgery group (<i>n</i> = 817), there were 19 (2.3%) and 13 (1.6%) cases of DVT and PE, respectively. DVT and PE incidence rates did not significantly differ between the MIS and open surgery groups (DVT: <i>p</i> = 0.67, PE: <i>p</i> = 0.80). Uni- and multivariate analyses revealed that an operative time &gt;6 h was associated with PE (<i>p</i> = 0.034).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>VTE incidence was low among patients with gynecological cancers who underwent MIS. VTE rates remained low following open surgery or MIS when appropriate anticoagulation was administered. However, caution should be exercised during prolonged surgeries.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.70054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three cases of pregnancies complicated with myotonic dystrophy type 1","authors":"Asako Kumagai,&nbsp;Yusen Sugimura,&nbsp;Satomi Tanaka,&nbsp;Shotaro Yata,&nbsp;Hiroshi Kaneda,&nbsp;Toshitaka Tanaka","doi":"10.1111/jog.70053","DOIUrl":"10.1111/jog.70053","url":null,"abstract":"<p>Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by trinucleotide repeat expansion. Pregnancies with DM1 are prone to complications, and congenital DM1 often presents with severe symptoms at birth. This report reviews three cases of congenital DM1 and explores potential predictive factors for both maternal and fetal DM1. Among the three cases, two were diagnosed with DM1 either before or during their current pregnancy. Although no common features were observed across all cases, elevated serum creatinine phosphokinase (CPK) levels were noted in two cases diagnosed with DM1 before labor. Despite all cases being congenital DM1, biophysical profile scores were normal. Severe congenital DM1 should be considered if unexpected neonatal asphyxia occurs even when typical signs such as polyhydramnios or abnormal fetal heart rate are absent. Maternal DM1 diagnosis was supported by elevated serum CPK, muscle weakness, and family history.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}