Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Expression patterns of aquaporin 9 in umbilical cord and fetal membranes in women with pregestational and gestational diabetes","authors":"Selin Kenan,&nbsp;Nuray Bostancıeri,&nbsp;Demet Taşdemir Kahraman,&nbsp;Ali Ovayolu,&nbsp;Çiğdem Karaca","doi":"10.1111/jog.70014","DOIUrl":"10.1111/jog.70014","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Aquaporins (AQPs) play crucial roles in the fetal development process. We aimed to investigate the expression patterns of AQP-9 in the umbilical cord and fetal membranes in pregnancies complicated by gestational diabetes mellitus (GDM) and pregestational diabetes mellitus (PGDM) compared to normoglycemic pregnancies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Samples of umbilical cord and fetal membranes were collected from women with GDM (<i>n</i> = 6), PGDM with nephropathy (White Class F) (<i>n</i> = 6). Histomorphologic evaluation was performed using hematoxylin–eosin staining. AQP-9 expression was analyzed by immunohistochemistry and quantitative real-time PCR (qPCR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Histologically, the GDM group showed increased umbilical cord diameter with edematous changes in Wharton's jelly, while the PGDM group exhibited decreased umbilical cord diameter. Immunohistochemical evaluation revealed significantly increased AQP-9 protein expression in vascular endothelium and amnion of both umbilical cord and fetal membranes in diabetic groups compared to controls, with the PGDM group showing the most intense immunoreactivity. qPCR demonstrated significantly decreased AQP-9 gene expression in umbilical cord of diabetic groups compared to controls (<i>p</i> = 0.026), while no significant differences in mRNA levels were found in fetal membranes between groups (<i>p</i> = 0.980).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>AQP-9 exhibits significantly increased protein expression in both umbilical cord and fetal membranes of diabetic pregnancies, while mRNA levels are decreased only in the umbilical cord of diabetic patients with no changes in fetal membranes. This tissue-specific discrepancy between protein upregulation and gene expression suggests complex post-transcriptional regulatory mechanisms in diabetes-affected pregnancies, providing novel insights into the molecular pathophysiology of maternal-fetal complications in diabetes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The AOFOG declaration on violence against women: A regional call to action for Asia and Oceania","authors":"Unnop Jaisamrarn,&nbsp;Pisake Lumbiganon,&nbsp;Rohana Haththotuwa,&nbsp;Jiayu Li,&nbsp;Alyssa L. Olson,&nbsp;Krishnendu Gupta,&nbsp;John Beng Ho Teo,&nbsp;Sze-yan Charleen Cheung,&nbsp;Kirsten I. Black,&nbsp;Soerjo Hadijono,&nbsp;Osamu Hiraike,&nbsp;Sadaqat Jabeen,&nbsp;Mandakini Megh,&nbsp;Ferdousi Begum,&nbsp;Darshana Bangamuwe Abeygunawardana,&nbsp;Sekaran Shantha Kumari,&nbsp;John David Tait","doi":"10.1111/jog.70004","DOIUrl":"10.1111/jog.70004","url":null,"abstract":"<p>Violence against women remains a severe human rights violation and public health challenge across Asia and Oceania, with significant variations in prevalence and response capacity among countries. Despite global frameworks such as the Convention on the Elimination of All Forms of Discrimination Against Women and regional initiatives like the ASEAN Declaration on the Elimination of Violence Against Women and Violence Against Children, implementation gaps hinder effective protection. The Asia-Oceania Federation of Obstetrics and Gynaecology (AOFOG) Declaration on Violence Against Women: A Commitment to Action and Change reinforces key commitments across 10 action areas, including recognizing violence against women as a critical issue, advancing international agreements, strengthening regional cooperation, mobilizing stakeholders, empowering healthcare professionals, enhancing comprehensive services, promoting public education, improving healthcare training, supporting research and data collection, and preparing for crisis responses such as pandemics. Emphasizing evidence-based policymaking and regional collaboration, the Declaration establishes a roadmap for accountability through robust monitoring and evaluation. By uniting stakeholders across sectors, AOFOG aims to eliminate VAW and foster environments where women's rights, safety, and dignity are universally upheld. This Declaration was officially presented at the 28th AOFOG Congress held in Busan, Korea, on May 18, 2024.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.70004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High uterosacral ligament suspension with vaginal natural orifice transluminal endoscopic surgery: A better alternative to sacrospinous fixation in postmenopausal women?","authors":"Ayşe Betül Albayrak Denizli,&nbsp;Eralp Bulutlar,&nbsp;Gizem Berfin Uluutku Bulutlar,&nbsp;Sadık Şahin","doi":"10.1111/jog.70017","DOIUrl":"10.1111/jog.70017","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Pelvic organ prolapse (POP) significantly impacts women's quality of life, often necessitating surgical intervention. Sacrospinous ligament fixation (SSF) and uterosacral ligament suspension (USLS) are commonly performed, mesh-free procedures for apical prolapse repair. While SSF provides durable support, it may alter vaginal axis alignment and compromise visualization, whereas traditional USLS is associated with ureteral complications. This study compares the perioperative and postoperative outcomes of SSF and Vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) high uterosacral ligament suspension (VN-HUSLS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective case series was conducted at Zeynep Kamil Hospital and included 50 patients with Stage 3 or 4 POP who underwent vaginal hysterectomy followed by SSF (<i>n</i> = 27) or VN-HUSLS (<i>n</i> = 23). Demographic data, operative times, hospitalization duration, POP-Q scores, recurrence rates, and complications were analyzed using SPSS (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No significant differences were found in age, BMI, or preoperative POP stage (<i>p</i> &gt; 0.05). Prolapse-specific surgical time was significantly shorter in the VN-HUSLS group (<i>p</i> &lt; 0.05). All VN-HUSLS patients underwent bilateral adnexectomy with preoperative indications, compared to five in the SSF group. Postoperative POP-Q scores showed better anatomical correction in the VN-HUSLS group, with sustained improvements at 6- and 12-month follow-ups. In the SSF group, two patients experienced recurrence, one at 6 months (Ba point +2) and the other at 12 months (Ba point +3). In the VN-HUSLS group, one patient was found to have Ba point at +1 at the 12-month follow-up, but this did not result in any additional symptoms for the patient.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>VN-HUSLS is a promising alternative to SSF, improving surgical outcomes while reducing recurrence and postoperative morbidity. Further studies are needed to evaluate long-term outcomes and postoperative sexual function.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heavy menstrual bleeding in adolescents: Prevalence, quality of life, and treatment-seeking behavior","authors":"Betül Sultan Haliç,&nbsp;Semra Kocaöz","doi":"10.1111/jog.70016","DOIUrl":"10.1111/jog.70016","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To determine the prevalence of heavy menstrual bleeding (HMB) in adolescents and the affecting factors and to examine the effect of this condition on their treatment-seeking behaviors and quality of life (QoL).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study was carried out with 299 girls aged 13–19 years and their parents who visited the pediatrics outpatient clinic for examination at a state hospital in a district in Turkey. Data were collected through a questionnaire form developed by the researchers and the Quality of Life Scale (QoLS) for Children, Adolescent Evaluation Form.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Around half of the adolescents (48.2%) were found to have HMB, and only 23.4% of those who reportedly had heavy/very heavy bleeding consulted a physician for this reason. No statistically significant difference was detected between the presence of HMB in adolescents and consulting a physician for heavy/very heavy bleeding. In comparison to those who did not have HMB, adolescents who had HMB were found to obtain significantly lower QoLS overall and subscale scores, except for the physical health dimension.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The results of this study suggest that HMB is common in adolescents, yet treatment-seeking behaviors on the issue are not at the desired level, which has negative effects on many areas of QoL.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of serum lipoprotein(a) in the early diagnosis of intrahepatic cholestasis of pregnancy","authors":"Xiaohong Zhu,&nbsp;Yeliang Sun,&nbsp;Yongli Zhou,&nbsp;Liping Han,&nbsp;Yuqin Hu,&nbsp;Qin Li,&nbsp;Yuhua Wei","doi":"10.1111/jog.70002","DOIUrl":"10.1111/jog.70002","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Intrahepatic cholestasis of pregnancy (ICP) represents the predominant hepatic condition that is specific to pregnancy and impacts expectant mothers. We desired to explore the clinical significance of serum lipoprotein(a) [Lp(a)] in the early diagnosis of ICP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective study was conducted on 156 ICP patients, with 88 healthy pregnant women with normal indicators during mid-to-late pregnancy selected as controls. Clinical baseline data of all participants were collected, and serum Lp(a) expression was measured by turbidimetric immunoassay. The association between fasting serum total bile acids (TBA) and serum Lp(a) in ICP patients was evaluated using Spearman correlation analysis. The value of serum Lp(a) was assessed using ROC analysis in assessing high-risk ICP patients and diagnosing early-onset ICP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The ICP group had significantly higher weight gain during pregnancy, family history of ICP, histories of cholecystectomy and gallbladder disease, with higher fasting serum TBA. The gestational age in the ICP group was significantly shorter, with increased serum Lp(a) levels. Serum Lp(a) levels enhanced with disease severity and were positively correlated with fasting serum TBA. Early-onset ICP patients had higher serum Lp(a) levels than late-onset ICP patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Serum Lp(a) levels increased with disease severity in ICP patients, providing effective guidance for early diagnosis and clinical treatment decisions in ICP patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Perinatal Committee report: Review of the progress of obstetric healthcare in Japan","authors":"Shoji Satoh,&nbsp;Atsuo Itakura,&nbsp;Tomoaki Ikeda,&nbsp;Kentaro Kurasawa,&nbsp;Akihito Nakai","doi":"10.1111/jog.16354","DOIUrl":"10.1111/jog.16354","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Japan's maternal mortality rate and perinatal mortality rate have shown one of the world's most significant declines, positioning Japan at the global forefront of the lowest levels. The nearly logarithmic annual decline in maternal and perinatal mortality rates suggests that, in addition to advances in medicine and healthcare, various types of care for mothers and newborns have played a crucial role in this achievement.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Method&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;From the period of World War II to the postwar era, up to around 1980, and then every decade thereafter, the events and movements surrounding perinatal healthcare in each era were examined from the perspectives of epidemiology, medical/healthcare advancements, and institutional/policy trends.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;div&gt;The major events in each era are outlined as follows:\u0000 &lt;ul&gt;\u0000 \u0000 &lt;li&gt;&lt;i&gt;Until around 1980&lt;/i&gt;: After World War II, in 1948, several laws were enacted to protect mothers and fetuses, including the Maternal and Child Health Handbook, in 1966. The number of births experienced a baby boom for about 10 years following 1945, peaking in 1973. Birthplaces shifted from home deliveries to medical facilities, with doctors becoming the primary birth attendants. Academically, the Japan Association of Obstetricians and Gynecologists (JAOG) for Maternal Protection and the Japan Society of Obstetrics and Gynecology (JSOG) were established in 1949. In the medical field, neonatal intensive care units (NICUs) were introduced and neonatal transport systems became well-established by the 1970s. In 1976, the limit of viability was revised from under 28 weeks of gestation to under 24 weeks. The late 1970s saw the fetal heart rate monitoring, the heartbeat detection using Doppler ultrasound and the ultrasound imaging techniques.&lt;/li&gt;\u0000 \u0000 &lt;li&gt;&lt;i&gt;1980s&lt;/i&gt;: The perinatal medicine became well established, leading to hold The Japan Society of Perinatal Medicine. For fetal management, the fields of fetal diagnosis and fetal treatment entered their early stages with the widespread use of fetal heart rate monitoring and ultrasound imaging. In neonatal care, neonatal transport systems to NICU facilities were enhanced. A major breakthrough in this field was the discovery and widespread use of pulmonary surfactant. Two key concepts that emerged and advanced during this period were maternal transport systems and the Perinatal Maternal and Child Center initiative. In 1987, cases of hepatitis caused by non-heat-treated coagulation products became a major iss","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16354","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy-specific reference intervals for complete blood count parameters in a Japanese cohort","authors":"Kanatsu Kawakami,&nbsp;Shimokawa Risa,&nbsp;Fumitaka Saito,&nbsp;Akihito Sagara,&nbsp;Saori Yoshimura,&nbsp;Yutaka Iwagoi,&nbsp;Munekage Yamaguchi,&nbsp;Shoichi Kawakami,&nbsp;Eiji Kondoh","doi":"10.1111/jog.70011","DOIUrl":"10.1111/jog.70011","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To establish gestational age-specific reference intervals for complete blood count (CBC) parameters in a Japanese population and examine the influence of maternal body mass index (BMI) and age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective cohort study was conducted at a single institution, analyzing eight CBC parameters in 33 355 singleton pregnancies. Reference intervals (2.5th–97.5th percentiles) for white blood cell count (WBC), red blood cell count (RBC), hemoglobin (Hb), hematocrit (Ht), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and platelet count (PLT) were determined across early (&lt;20 weeks), mid (20–29 weeks), and late (≥30 weeks) pregnancy. One-way analysis of variance with Tukey's intervals assessed the impact of BMI and age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Up to 69 758 values per parameter were analyzed. WBC, MCV, and MCH increased in mid-pregnancy and then declined, while RBC and Ht reached their lowest levels in mid-pregnancy before partial recovery. Hb, MCHC, and PLT steadily decreased. Higher BMI was associated with higher WBC, RBC, Hb, Ht, and PLT at all gestational periods (<i>p</i> &lt; 0.001). WBC declined, whereas MCV and MCH increased with maternal age, with more marked differences in late pregnancy. Hb decline was more evident in teenagers and women in their early 20s. Longitudinal comparisons showed lower WBC and higher PLT in the latest pregnancy compared to the preceding one (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study provides pregnancy-specific CBC reference intervals and highlights the need to consider BMI- and age-related factors in prenatal hematological assessment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiologies and clinical characteristics of primary amenorrhea: A study from a quaternary care hospital in southern Thailand","authors":"Krantarat Peeyananjarassri,&nbsp;Satit Klangsin,&nbsp;Patchayapan Bhumsiriwilai,&nbsp;Saranya Wattanakumtornkul,&nbsp;Rassamee Chotipanvithayakul","doi":"10.1111/jog.70009","DOIUrl":"10.1111/jog.70009","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to investigate the causes and clinical characteristics of patients presenting with primary amenorrhea.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective review was conducted on patients diagnosed with primary amenorrhea at a quaternary care center in southern Thailand between January 2002 and September 2024. Patients with missing data or ambiguous genitalia were excluded. Primary amenorrhea was categorized into three main etiologies: hypergonadotropic hypogonadism (characterized by low serum estradiol and elevated follicle-stimulating hormone [FSH] levels, indicative of ovarian or gonadal disorders), hypogonadotropic hypogonadism (low serum estradiol with low or normal serum FSH levels, associated with hypothalamic–pituitary dysfunction), and eugonadotropic eugonadism (disorders of the uterus or genital outflow tract). Other conditions included anovulation, hyperprolactinemia, and thyroid disorders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 320 patients included, 150 (46.9%) were classified as having eugonadotropic eugonadism. Among these, Müllerian agenesis was the most common cause (33.8%), followed by gonadal dysgenesis (28.8%). Patients with genital outflow tract obstruction were diagnosed at a significantly younger median age compared to those with Müllerian agenesis (14 years [interquartile range; IQR 13, 16] vs. 20 years [IQR 18, 24]; <i>p</i> &lt; 0.001). Serum FSH levels differed significantly across the three main categories, with higher levels observed in hypergonadotropic hypogonadism (81.1 IU/L [IQR 65.2, 95.0]) compared to hypogonadotropic hypogonadism (0.8 IU/L [IQR 0.3, 3.4]) and eugonadotropic eugonadism (5.2 IU/L [IQR 3.5, 6.3], <i>p</i> &lt; 0.001). Among patients with hypergonadotropic hypogonadism and hypogonadotropic hypogonadism who underwent ultrasonography (USG) (<i>n</i> = 100), the uterus was not visualized in 44 cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Müllerian agenesis emerged as the most frequent cause of primary amenorrhea, although it tended to be diagnosed later than genital outflow tract obstruction. Caution is warranted when assessing the presence of the uterus by USG, particularly in patients with hypergonadotropic hypogonadism or hypogonadotropic hypogonadism.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor growth direction predicts surgical difficulty in large uterine fibroids: A retrospective imaging-based study","authors":"Satoshi Tamauchi,&nbsp;Kaoru Niimi,&nbsp;Shohei Iyoshi,&nbsp;Kosuke Yoshida,&nbsp;Kazumasa Mogi,&nbsp;Masato Yoshihara,&nbsp;Yukari Nagao,&nbsp;Akira Yokoi,&nbsp;Nobuhisa Yoshikawa,&nbsp;Hiroaki Kajiyama","doi":"10.1111/jog.70013","DOIUrl":"10.1111/jog.70013","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To identify preoperative imaging features associated with retroperitoneal growth of large uterine fibroids and evaluate their impact on surgical outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included 20 patients who underwent hysterectomy for uterine fibroids measuring ≥10 cm between 2014 and 2024. Preoperative CT or MRI was evaluated for four features: bladder displacement, sigmoid colon deviation, cecal displacement, and hydronephrosis. Tumor growth direction (intraperitoneal vs. retroperitoneal) was determined intraoperatively. Operative time, blood loss, and complications were compared between groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eight tumors exhibited retroperitoneal growth. Bladder displacement, cecal shift, sigmoid colon deviation, and hydronephrosis were significantly more common in retroperitoneal cases (all <i>p</i> &lt; 0.05). Retroperitoneal tumors were associated with significantly greater median blood loss (1591 mL vs. 651 mL, <i>p</i> = 0.043), although operative time did not differ significantly (301 vs. 232 min, <i>p</i> = 0.237). Organ injury or resection occurred only in the retroperitoneal group. A bubble plot illustrated the trend of increased surgical burden in retroperitoneal cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Retroperitoneal growth of large uterine fibroids is associated with increased intraoperative blood loss and surgical complexity. Four simple imaging features may serve as reliable indicators of growth direction and help guide preoperative planning.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The involvement of ribonucleoproteins in promoting epithelial ovarian cancer through a systems biology approach","authors":"Dastan Abdullah,&nbsp;Vyan Qadir,&nbsp;Dawan J. Hawezy,&nbsp;Marwa Fadhil Alsaffar,&nbsp;Mahla Masoudi,&nbsp;Ali Qorbanee,&nbsp;Hossein Azizi","doi":"10.1111/jog.16360","DOIUrl":"10.1111/jog.16360","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Epithelial ovarian cancer (EOC), originating from the ovarian epithelial cells, represents approximately 90% of all ovarian cancer cases and includes several subtypes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study investigates the role of hub ribonucleoprotein genes in EOC progression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Microarray datasets GSE28799 and GSE54388 from GEO were analyzed using Transcriptome Analysis Console (TAC) software for differential expression (<i>p</i> ≤ 0.05, LogFC ≥4). Upregulated RNP genes, including FBL and HNRNPC, were identified. Protein–protein interactions were analyzed using STRING and visualized in Cytoscape. Clustering was performed with Gephi software. Gene expression and alterations were validated using the HPA and cBioPortal databases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>FBL and HNRNPC were significantly upregulated in EOC, playing key roles in tumor progression. Network analysis showed close interactions within the same gene cluster. Pathway enrichment linked them to spliceosome and ribosome biogenesis, affecting gene regulation and cellular function. Samples with FBL and HNRNPC deletions showed lower mRNA expression. Survival analysis indicated that their upregulation negatively affects patient survival, suggesting that disrupting these genes could slow cancer progression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study highlights the crucial role of FBL and HNRNPC in EOC. These genes are significantly upregulated and actively contribute to key cellular processes like spliceosome function and ribosome biogenesis, which help sustain tumor growth. Through network and pathway analyses, researchers have uncovered their strong functional connection, further emphasizing their importance in cancer biology. Notably, higher expression levels of these genes are linked to poorer patient survival. Targeting and disrupting their expression may provide new strategies to slow tumor progression and improve patient outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}