Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Association of opportunistic bacterial pathogens with female infertility: A case–control study","authors":"Zahid Hasan,&nbsp;Nurjahan Begum,&nbsp;Sangita Ahmed,&nbsp;Mahmuda Yasmin","doi":"10.1111/jog.16243","DOIUrl":"https://doi.org/10.1111/jog.16243","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Infertility affects a significant proportion of women worldwide, and the colonization of certain vaginal pathogens has been suggested as a possible contributing factor. To explore the relationship between bacterial pathogens and female infertility, a case–control study was conducted involving 55 infertile women as cases and 5 fertile women as controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Conventional culture-based techniques and biochemical assays followed by 16S rDNA sequence analysis were employed for the identification of vaginal isolates from the two groups. The strength of association between the isolated bacterium and infecundity was derived by odds ratio calculation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The investigation revealed the presence of bacteria including <i>Enterococcus faecalis</i>, <i>Escherichia coli</i>, <i>Bacillus</i> spp., <i>Acinetobacter baumannii</i>, <i>Pseudomonas</i> spp., <i>Micrococcus luteus</i>, <i>Staphylococcus aureus</i>, <i>Staphylococcus haemolyticus</i>, <i>Staphylococcus hominis</i>, <i>Staphylococcus capitis</i>, <i>Staphylococcus epidermidis</i>, and <i>Staphylococcus saprophyticus</i> in the vaginal swabs of infertile women. Of these, the odds ratios for <i>Staphylococcus aureus</i>, <i>Klebsiella pneumoniae</i>, <i>E. faecalis</i>, and <i>E. coli</i> were 5.43 (95% CI = 0.28, 103.49), 4.59 (95% CI = 0.24, 87.93), 2.25 (95% CI = 0.11, 44.16), and 1.70 (95% CI = 0.09, 34.01), respectively, displaying an association with infertility. Moreover, vaginal colonization of these four bacterial species was also dominant in cases that were diagnosed with pelvic inflammatory disease and idiopathic infertility by laparoscopic examination.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Overall, the findings of this study indicate a probable association between specific pathogenic microorganisms and women's barrenness, emphasizing the significant role of these disease-causing agents in hindering conception. This highlights the significance of a complete understanding of the vaginal microbiome and emphasizes further research in this area.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference line lengthening on resting-state magnetic resonance imaging in patients with pelvic organ prolapse seeking surgical treatment","authors":"Yoshiyuki Okada,&nbsp;Chie Nakagawa,&nbsp;Ippei Kurokawa,&nbsp;Miwa Shigeta,&nbsp;Yukiko Nomura,&nbsp;Eisuke Inoue,&nbsp;Yasukuni Yoshimura","doi":"10.1111/jog.16248","DOIUrl":"https://doi.org/10.1111/jog.16248","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Injury to and laxity of the pelvic floor muscles are highly important factors in the etiology of pelvic organ prolapse. When women with pelvic organ prolapse perform the Valsalva maneuver, progressive descent and widening of the levator ani muscle are observed on dynamic magnetic resonance images. However, physical examination of such women often reveals pelvic floor laxity, even in a relaxed state. Therefore, we aimed to verify the hypothesis that sagging of the pelvic floor can be detected on resting-state magnetic resonance images in the supine position.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively evaluated resting-state magnetic resonance imaging findings in women with (<i>n</i> = 193; all underwent surgical treatment) and without (controls; <i>n</i> = 193) pelvic organ prolapse who had at least one prior vaginal delivery. We compared the lengths of the pubococcygeal line, H-line, and M-line between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median lengths (interquartile ranges) for the prolapse and control groups were 98.3 (91.9–104.0) and 95.1 (90.3–101.4) mm (<i>p</i> = 0.0011), respectively, for the pubococcygeal line; 61.5 (56.0–67.9) and 51.1 (47.2–55.6) mm (<i>p</i> &lt; 0.0001), respectively, for the H-line; and 24.6 (20.4–29.0) and 8.6 (3.9–13.0) mm (<i>p</i> &lt; 0.0001), respectively, for the M-line. Similarly, in the multiple regression analysis adjusted for age, height, body mass index, a history of operative vaginal delivery, and a history of hysterectomy, the pubococcygeal line, H-line, and M-line were significantly longer in the prolapse group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In women with pelvic organ prolapse, the H-line and M-line are significantly longer on resting-state magnetic resonance images, allowing for the detection of pelvic floor relaxation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trimethylamine N-oxide induces pyroptosis in HTR8-S/Vneo cells through the ten-eleven translocation 2-cytochrome b-reactive oxygen species pathway","authors":"Lingli Liang,&nbsp;Yuzhu Rao,&nbsp;Jingjing Wang,&nbsp;Jinli Zhao,&nbsp;Lu He,&nbsp;Jun Meng,&nbsp;Peng Wu,&nbsp;Zuo Wang","doi":"10.1111/jog.16237","DOIUrl":"https://doi.org/10.1111/jog.16237","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aim&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Pyroptosis is a type of programmed cell death characterized by pro-inflammatory activity and is an important factor in pre-eclampsia (PE). Trimethylamine N-oxide (TMAO) is a gut microbial metabolite closely associated with pyroptosis and PE. This study aims to investigate the role of TMAO in trophoblast cell pyroptosis and explore possible mechanisms.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Western blot and qRT-polymerase chain reaction (PCR) were used to detect the expression levels of ten-eleven translocation 2 (TET2), cytochrome b (CYTB), pyroptosis-related molecules, and mitochondrial proteins. The level of mitochondrial reactive oxygen species (mtROS) was detected by fluorescent probe DCFH-DA. Immunofluorescence was used to measure the level of 5-hydroxymethylcytosine (5hmC). TET2 overexpression/silencing and CYTB overexpression/silencing lentiviruses were transfected into HTR8/SVneo cells, respectively. MitoTEMPO was used to reduce mtROS. TMAO levels in placental tissues were quantified by liquid chromatography-tandem mass spectrometry (LC–MS/MS), and representative extracted ion chromatograms were analyzed for retention times and peak areas. ELISA was used to further validate TMAO concentrations in placental tissues.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;TMAO is capable of enhancing the expression of proteins related to pyroptosis (including NLRP3, GSDMD, GSDMD-N, Caspase-1) as well as inflammatory factors (such as IL-1β, IL-18) in HTR8-S/Vneo cells. Meanwhile, the positive rate of propidium iodide (PI), mtROS levels, and intracellular Ca2+ levels all increased. Electron microscopy results showed an increase in mitochondrial membrane pore numbers, abnormal mitochondrial morphology, and downregulation of the expression levels of mitochondrial proteins nuclear respiratory factor 1 (NRF1), NRF2, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), and NADH dehydrogenase subunit 2 (ND2). LC–MS/MS and ELISA analyses revealed significantly elevated TMAO levels in PE placental tissues compared to normal tissues, further supporting the role of TMAO accumulation in placental dysfunction associated with PE. Overexpression of CYTB inhibited TMAO-induced pyroptosis and mitochondrial dysfunction (MDF) in HTR8-S/Vneo cells, while silencing of CYTB promoted pyroptosis and MDF in HTR8-S/Vneo cells, but this condition could be partially reversed by MitoTEMPO. TMAO inhibited the expression of TET2 and CYTB and downregulated the level of 5hmc. The results of TET2 overexpression/knockout indicated that the expression of CYTB was regulated by TET2, and overexpression of TET2 alleviated TMAO-induced pyroptosis and MDF as well as the decrease in 5hmc lev","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effect of Kegel plus abdominal exercises and Kegel only exercises on urinary incontinence severity, quality of life, and sleep quality in postmenopausal women with stress urinary incontinence: A randomized controlled trial","authors":"Şükran Başgöl,&nbsp;Emine Koç,&nbsp;Meltem Mecdi Kaydırak","doi":"10.1111/jog.16233","DOIUrl":"https://doi.org/10.1111/jog.16233","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The purpose of this study was to compare the effect of Kegel exercises plus abdominal exercises to Kegel only exercises on urinary incontinence severity, quality of life, and sleep quality in postmenopausal women with stress urinary incontinence (SUI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective, randomized controlled trial adhered to the CONSORT guidelines and included 70 postmenopausal women (35 in each group) diagnosed with SUI who attended an Obstetrics and Gynecology outpatient clinic in northern Turkey between May and November 2023. The experimental group performed Kegel and abdominal exercises, while the control group practiced Kegel exercises only. Both groups followed a 12-week exercise program, with data collected through pre- and post-tests and three face-to-face interviews during the intervention period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After the 12-week exercise programs, both Kegel only and Kegel plus abdominal exercise combination decreased the severity of incontinence and improved quality of life and sleep quality in postmenopausal women with SUI (<i>p</i> &lt; 0.001). However, in this population, Kegel plus abdominal exercises give better results than Kegel only exercises (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>According to the outcome of this evidence-based study, it is recommended that exercise programs combining Kegel and abdominal exercises be established for postmenopausal women with SUI within the scope of conservative treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Letter to Human-written versus ChatGPT-generated case reports”","authors":"Shigeki Matsubara","doi":"10.1111/jog.16240","DOIUrl":"https://doi.org/10.1111/jog.16240","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota and potential serum metabolites biomarkers of pregnant woman for preeclampsia","authors":"Qingju Meng,&nbsp;Jingjin Gong,&nbsp;Junwei Wu,&nbsp;Fang Chen,&nbsp;Yanqiu Li","doi":"10.1111/jog.16229","DOIUrl":"https://doi.org/10.1111/jog.16229","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The pathogenesis of preeclampsia (PE) remains unclear, but the interaction between intestinal flora and PE has been attention in recent studies. Several studies have shown that imbalanced intestinal flora plays an important role in the inducement of PE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The potential correlation among intestinal flora, metabolites, and fetal growth restriction was explored by integrating data and analyzing neonatal growth. The study is hoped to provide references for subsequent studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comparison between the intestinal flora of healthy pregnant women and pregnant with PE was conducted using 16S rRNA gene sequencing. Subsequently, the feces, serum and umbilical cord blood collected from healthy pregnant women and those with PE were analyzed using global untargeted metabolomics to identify differences in metabolites.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results showed that <i>Bifidobacterium</i>, <i>Chryseobacterium</i>, <i>Eubacterium</i>, <i>Pravotella</i> and <i>Bacteroides</i> are the core species associated with many metabolites. Normal-birth weight had a negative correlation with the abundance of raclopride, Phe-Gly-O and Lys-Phe-OH showed a positive correlation with Phosphonate and Lys-Gly. Simultaneously, these core metabolites showed a strong correlation with other growth indices (BPD, AC, FL). In summary, the imbalance of intestinal flora in pregnant women may alter the abundance of the core metabolites, thereby affecting the neonatal growth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A global untargeted metabolomics was performed on the samples including feces, serum, and umbilical cord blood. The integrated multi-omics analysis revealed the interaction among intestinal flora, metabolites and the clinical indices, demonstrating the potential effects of the imbalance of intestinal flora on neonatal growth in the pregnant women with PE.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of menstrual symptoms and genital hygiene behaviors of female healthcare professionals after the earthquake in Türkiye","authors":"Reyyan Gürel,&nbsp;Rabia Atilla,&nbsp;Vildan Savaş","doi":"10.1111/jog.16231","DOIUrl":"https://doi.org/10.1111/jog.16231","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of this study was to describe the post-earthquake menstrual symptoms, genital hygiene behaviors and the relationship between them among female healthcare workers who experienced the devastating earthquake in February 2023.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The sample of this descriptive and cross-sectional study consists of female healthcare professionals working in a public hospital in Iskenderun. Data were collected through face-to-face interviews between June 7 and September 7, 2023. Sociodemographic Form, Menstrual Symptom Scale, and Genital Hygiene Scale were used as data collection tools.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean age of the participants was 34.07 ± 8.08. Before the earthquake, 81.5% had regular menses, while in 58.6% of them the pattern of menses changed after the earthquake. It was found that there was a negative and weakly significant relationship between the total mean scores of “Menstrual Symptom Scale” and “Genital Hygiene Scale” (<i>p</i> &lt; 0.05). Significant differences were found between “age,” “perceived income level,” “marital status,” and “experiencing women's health problems after the earthquake” with menstrual symptoms. Additionally, significant differences were observed between “changes in menstrual regulation after the earthquake,” “the major earthquake's impact on the availability of hygienic products,” and genital hygiene behaviors (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>It was determined that the menstrual symptoms experienced by health workers after the earthquake were above moderate severity and their genital hygiene behaviors were less positive. Furthermore, genital hygiene behaviors were more negatively affected as the severity of menstrual symptoms increased.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide survey on the transition of treatment protocols after the introduction of insurance coverage for assisted reproductive technology in Japan: The IZANAMI project","authors":"Keiji Kuroda,&nbsp;Seung Chik Jwa,&nbsp;Hiromitsu Shirasawa,&nbsp;Miyuki Harada,&nbsp;Yutaka Osuga,&nbsp;Mitsutoshi Yamada","doi":"10.1111/jog.16234","DOIUrl":"https://doi.org/10.1111/jog.16234","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>How has the treatment policy changed since the introduction of health insurance coverage for assisted reproductive technology (ART) in Japan?</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study was conducted as a nationwide fact-finding survey to determine the current situation of ART treatment in Japan, the IZANAMI project. Among the 616 ART facilities across Japan, 283 (45.9%) that responded to the first (December 2021–February 2022) and second surveys (December 2023–January 2024) were recruited. Information on the clinical practices was collected via a questionnaire survey and analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the facilities with ≤200, 201–500, 501–1000, 1001–2000, and ≥2000 annual oocyte retrieval (OR) cycles, 93.9%, 88.7%, 75.0%, 69.7% and 42.9% performed ≥80% of their OR cycles using health insurance, respectively (<i>p</i> &lt; 0.001), whereas 51.9%, 53.7%, 41.0%, 40.0% and 12.5% exhibited an increase in number of OR cycles, respectively (<i>p</i> = 0.03). Therefore, a significantly higher proportion of smaller-scale institutions than larger clinics had insured treatment and an increase in the number of OR cycles. Significantly more large clinics than small facilities selected mild stimulation, intracytoplasmic sperm injection, and freeze-all embryo cycle; however, no significant transitions were observed in the main policies for ART, regardless of facility size. However, the indication for mild stimulation significantly increased in normal to high responders, and the choice of ovarian stimulation protocol according to the patient's wishes was significantly reduced.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Small-scale institutions were more likely to offer insured treatment and increase the number of OR cycles than large facilities; however, the main protocols did not significantly change.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraskeletal myxoid chondrosarcoma mimicking mucinous ovarian cancer: A case report","authors":"Sebile Güler Çekiç,&nbsp;Ömer Faruk Atay,&nbsp;Volkan Ülker,&nbsp;Özgür Akbayir","doi":"10.1111/jog.16235","DOIUrl":"https://doi.org/10.1111/jog.16235","url":null,"abstract":"<p>Pelvic masses can represent various etiologies, including gynecologic and non-gynecologic conditions. As discussed in this paper, among all pathologies, intraabdominal dissemination of an extraskeletal myxoid chondrosarcoma (ESMC) presenting as a pelvic mass is a rare condition. The case is a 58-year-old woman with a history of soft tissue sarcoma who presented to the gynecologic oncology department with a pelvic mass and was operated on with the suspicion of mucinous ovarian cancer. She underwent complete cytoreductive surgery, and her final pathology was reported as ESMC. Due to several numbers of metastases shown in positron emission tomography-computed tomography, she had chemotherapy and then operated on for tumorectomy from the right leg. ESMC is a rare, aggressive soft tissue neoplasm that rarely has metastasis to the abdomen. This unique case presents a late recurrence of the disease to the pelvis, which can mimic mucinous ovarian cancer.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of oral postbiotics on the restoration of pelvic floor muscle function","authors":"Yuan Xu,&nbsp;Yawei Yang,&nbsp;Ruxin Chen,&nbsp;Can Li,&nbsp;Mingdian Li,&nbsp;Qingxi Yuan,&nbsp;He Gao","doi":"10.1111/jog.16236","DOIUrl":"https://doi.org/10.1111/jog.16236","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To elucidate the efficacy and underlying mechanisms of postbiotics in ameliorating stress urinary incontinence (SUI) in a rat model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>SUI model was established via pelvic floor injury and bilateral ovariectomy to simulate postmenopausal conditions. Following successful model induction, subjects were randomly allocated into control, model, positive drug, and experimental groups. The positive drug group received midodrine hydrochloride (20 mg/kg), while the experimental group received postbiotics (75 mg/kg) daily for 28 days. Urodynamic and abdominal leak point pressure tests were conducted on days 7, 14, 21, and 28. After 28 days, histopathology and western blot analysis for collagen I (Col I), collagen III (Col III), and elastin, as well as quantitative polymerase chain reaction for gene expression, were performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The model group showed abnormal urodynamic waveforms and lower maximum abdominal leak point pressure compared to controls. Histopathology revealed muscle fiber disarray, fiber rupture, and decreased muscle thickness. Both mRNA and protein levels of Col I, Col III, and Elastin were reduced. Midodrine improved urodynamic parameters and pathology, increasing Col I, Col III, and Elastin levels. Postbiotics also improved urodynamic parameters and pathology, with increased protein levels of Col I, Col III, and Elastin, and upregulated mRNA levels of Col I, Col III, Elastin, and transforming growth factor β1.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Postbiotics demonstrate therapeutic potential in alleviating SUI in rats by upregulating the expression of Col I, Col III, Elastin, and transforming growth factor β1 genes, enhancing collagen and elastin protein content in sphincter and pubococcygeus muscles, and consequently restoring muscle contractility and function.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}