Influence of equol production capacity on female lower urinary tract symptoms

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-03-25 DOI:10.1111/jog.16266

Chie Nakagawa, Yoshiyuki Okada, Miwa Shigeta, Yukiko Nomura, Akihiko Sekizawa, Yasukuni Yoshimura

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Abstract

Aim

We aimed to investigate the relationship between lower urinary tract symptoms in females and their equol production capacity.

Methods

In this cross-sectional study, the production capacity of equol in Japanese women (aged 20–75 years), with (group L, n = 95) and without (group C, n = 122) lower urinary tract symptoms, was examined. Equol production was determined by measuring the concentration of urinary equol by immunochromatography. Equol production was defined as a urinary equol concentration of 1.0 μM or more. The presence of lower urinary tract symptoms was determined using three questionnaires that evaluated lower urinary tract symptoms.

Results

The proportions of equol production in groups L and C were 28.4% and 52.5%, respectively (p = 0.0004). Multivariate analysis (logistic regression analysis) showed that the inability to produce equol was a significant risk factor for lower urinary tract symptoms (odds ratio, 2.21; p = 0.0144).

Conclusions

This study revealed that equol production capacity may be associated with lower urinary tract symptoms. Further research, including interventional studies, is required for verification. Additionally, because lower urinary tract symptoms include a variety of symptoms, the association between each symptom and equol production capacity needs to be investigated.

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.