Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Analysis of factors influencing endometrial polyp recurrence after hysteroscopic polypectomy","authors":"Xiaoning Li,&nbsp;Xiaopeng Zhao,&nbsp;Beibei Wang,&nbsp;Jun Bai,&nbsp;Qiaoxia Qi,&nbsp;Danni Li,&nbsp;Lili Yang,&nbsp;Hongli Zhu","doi":"10.1111/jog.16352","DOIUrl":"https://doi.org/10.1111/jog.16352","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To analyze the factors influencing the recurrence of endometrial polyps after hysteroscopic polypectomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective analysis was conducted on the clinical data of 925 patients who underwent hysteroscopic polypectomy for endometrial polyps at the Affiliated Hospital of Shaanxi University of Chinese Medicine from January 2017 to December 2023. All patients were followed up for 6 months, and the factors influencing the recurrence of endometrial polyps after hysteroscopic polypectomy were analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The recurrence rate of endometrial polyps after hysteroscopic polypectomy was 7.78% (72/925). Significant differences were observed between the recurrence and non-recurrence groups in terms of body mass index (BMI), menopausal status, levels of luteinizing hormone (LH), estradiol (E2), follicle-stimulating hormone (FSH), endometrial thickness, and polyp diameter (<i>p</i> &lt; 0.05). Multivariate logistic regression analysis showed that high BMI, elevated levels of LH, E2, and FSH, increased endometrial thickness, and larger polyp diameter were independent risk factors for the recurrence of endometrial polyps after hysteroscopic polypectomy (odds ratio &gt;1, <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>High BMI, elevated levels of LH, E2, and FSH, increased endometrial thickness, and larger polyp diameter increase the risk of recurrence of endometrial polyps after hysteroscopic polypectomy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of post-warming culture duration and blastocyst morphology on reproductive outcomes in vitrified–warmed cycles: A retrospective cohort study","authors":"Jae Kyun Park,&nbsp;Ji Young Hwang,&nbsp;Soyoung Bang,&nbsp;Yunmi Jeon,&nbsp;Min Kyoung Kim,&nbsp;Ji Won Kim,&nbsp;Woo Sik Lee","doi":"10.1111/jog.16357","DOIUrl":"https://doi.org/10.1111/jog.16357","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The use of vitrified–warmed blastocyst transfer (VBT) cycles has increased significantly. This study aimed to investigate the effects of the post-warming culture duration and blastocyst morphology on clinical outcomes in VBT cycles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective cohort study of 1551 VBT cycles. After propensity score matching to adjust for confounding variables, cycles were categorized based on post-warming culture duration into short-period (SPC; <i>n</i> = 365) and long-period (LPC; <i>n</i> = 730) culture groups. Blastocysts were classified into good (GG; <i>n</i> = 413) and poor morphological grade (PG; <i>n</i> = 289) groups. Clinical pregnancy and miscarriage rates were compared between groups to assess correlations with culture duration and morphological quality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the GG group, post-warming culture duration was not significantly associated with survival, clinical pregnancy, implantation, ongoing pregnancy, or miscarriage rates for both single and double embryo transfers. However, in the PG group, the miscarriage rate was significantly higher in the SPC group than in the LPC group (26.7% vs. 2.6%). Furthermore, the SPC-PG group showed increased vulnerability in embryonic markers (positive markers: 82.5% vs. 69.5%; negative markers: 17.5% vs. 30.5%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Overall, no statistically significant differences were observed in clinical and ongoing pregnancy rates between the SPC and LPC groups. These findings suggest that while the timing of embryo transfer (ET) after warming can be adjusted to optimize each laboratory's workflow, the primary determinant of ET strategy should be blastocyst morphology, with culture duration tailored accordingly.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in proportions of Cesarean section before and during the COVID-19 pandemic in Japan","authors":"Kensuke Shimada,&nbsp;Jun Komiyama,&nbsp;Takehiro Sugiyama,&nbsp;Shin Jung-Ho,&nbsp;Tomomi Kihara,&nbsp;Rie Masuda,&nbsp;Susumu Kunisawa,&nbsp;Masao Iwagami,&nbsp;Isao Muraki,&nbsp;Yuichi Imanaka,&nbsp;Hiroyasu Iso,&nbsp;Nanako Tamiya","doi":"10.1111/jog.16370","DOIUrl":"https://doi.org/10.1111/jog.16370","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>After the coronavirus disease 2019 (COVID-19) pandemic, Cesarean sections for COVID-19-positive cases were performed to reduce delivery time and thus control infection. This may have increased the proportion of Cesarean sections and affected many pregnant women in Japan; though this expected trend has not yet been quantified. This study examined changes in the proportions of Cesarean sections in Japan before and during the pandemic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study retrospective observational study used the National Database of Health Insurance Claims and Specific Health Checkups of Japan and Vital Statistics from the National Statistical Surveys from April 2018 to October 2022. We compared proportions of Cesarean sections (total Cesarean sections/total live births) in Japan before and during the pandemic and by the COVID-19 pandemic phase: pre-COVID-19 (April 2018 to December 2019), Wave 1 (January to May 2020), Wave 2 (June to October 2020), Wave 3 (November 2020 to February 2021), Wave 4 (March to June 2021), Wave 5 (July to December 2021), Wave 6 (January to June 2022), and Wave 7 (July to October 2022).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The proportion of Cesarean sections in Japan was 20.27% (317 241/1 564 912) before the pandemic and increased to 21.19% (486 172/2 294 488) during the pandemic. The highest proportion was in Wave 6 (22.14%), dropping to 21.27% in Wave 7.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The overall proportion of Cesarean sections increased by 0.92% point during the COVID-19 pandemic in Japan, possibly due in part to infection control measures. Verification and preparation are necessary to respond to future pandemics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16370","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of the level by which women were influenced by the earthquake on their menstrual cycles","authors":"Ceylan Güzel Inal,&nbsp;Sermin Timur Taşhan","doi":"10.1111/jog.16350","DOIUrl":"https://doi.org/10.1111/jog.16350","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The impact of the Kahramanmaraş earthquake on the menstrual cycles of surviving women was investigated in this research.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study included 233 single women aged 15–49 affected by the earthquake. An online questionnaire that was created on Google Forms and whose link was sent to the women via the WhatsApp application was used to collect the data. This questionnaire included a descriptive information form, the impact of event scale (IES), and the Visual Analog Scale.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The duration of women's menstrual bleeding decreased following the earthquake, their menstrual cycles became irregular, and hormonal drug use to regulate the cycle, the occurrence of dysmenorrhea, and its severity increased (<i>p</i> &lt; 0.05). The mean IES scores of those reporting that the amount of menstrual bleeding decreased, that their cycles became irregular, and that the severity of dysmenorrhea increased following the earthquake were significantly greater (<i>p</i> &lt; 0.05). The results of the binary logistic regression analysis indicated that when the effect of the earthquake on women increased by one unit, as shown by their total IES score, the risk of change in the amount of menstrual bleeding increased by 0.046 times (<i>p</i> = 0.000), the risk of irregular menstrual cycles increased by 0.022 times (<i>p</i> = 0.005), and the risk of experiencing severe dysmenorrhea increased by 0.028 times (<i>p</i> = 0.000).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Natural disasters such as earthquakes negatively affect women's menstrual cycles. It is recommended that health professionals consider that women's menstrual cycles will be affected following disasters and support them in improving their menstrual cycles.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic challenges in uterine tumor resembling ovarian sex cord tumor: Two case reports","authors":"Yunqi Liu,&nbsp;Dong Zhang,&nbsp;Linzhi Gao,&nbsp;Siqi Zhou,&nbsp;Yuan Shen","doi":"10.1111/jog.70000","DOIUrl":"https://doi.org/10.1111/jog.70000","url":null,"abstract":"<p>Uterine tumors resembling ovarian sex cord tumors (UTROSCTs) are rare neoplasms, with cervical involvement posing exceptional diagnostic challenges. We report two cases: Case 1: a 43-year-old woman presenting with abnormal uterine bleeding and a cervical mass. An initial biopsy misinterpreted the lesion as a perivascular epithelioid cell tumor (PEComa), resulting in modified radical hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymphadenectomy. Subsequent multi-institutional histopathological consultation confirmed cervical UTROSCT. Case 2: a 53-year-old postmenopausal woman underwent hysteroscopic resection for endometrial thickening revealing UTROSCT, prompting total hysterectomy with bilateral salpingo-oophorectomy. Both patients remain disease-free at 72 and 3 months postoperatively. These cases highlight UTROSCT's non-specific imaging features and frequent histomorphologic overlap with other benign and malignant entities, particularly in the cervix, necessitating immunohistochemical differentiation. Case 1 underscores how diagnostic error can lead to overtreatment. Comprehensive immunohistochemical evaluation is critical for accurate diagnosis. Although total hysterectomy remains standard management, fertility-sparing options may be appropriate for select patients. Long-term surveillance is recommended due to the risk of recurrence.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential preoperative three-dimensional computed tomography for para-aortic lymphadenectomy in gynecological malignancies","authors":"Shintaro Yanazume,&nbsp;Fumitaka Ejima,&nbsp;Yusuke Kobayashi,&nbsp;Ayumi Kozai,&nbsp;Mika Fukuda,&nbsp;Shinichi Togami,&nbsp;Takashi Yoshiura,&nbsp;Hiroaki Kobayashi","doi":"10.1111/jog.16367","DOIUrl":"https://doi.org/10.1111/jog.16367","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The evaluation of anatomical abnormalities involving urinary vessel variations prior to para-aortic lymphadenectomy in gynecological malignancies is challenging. In this context, the utility of preoperative three-dimensional (3D) computed tomography (3DCT) angiography in improving surgical outcomes was examined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study evaluated the utility of 3DCT in patients who underwent para-aortic lymphadenectomy between January 2023 and November 2024. 3D fusion images were constructed from the arterial phase, CT-venography, and CT-urography. A total of 72 patients were included and divided into two groups: non-3DCT and 3DCT. Outcomes included detection rates of arterial, venous, or urinary tract variations and surgical outcomes, including complications, in both groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The 3DCT group included 14/34 (41.2%) cases with renal vessel variations and two cases (5.9%) with double ureters; the non-3DCT group did not detect any anatomical abnormalities. In the 3DCT group, renal vessel and urinary tract variations were clearly shown. Postoperative complications tended to be slightly higher in the non-3DCT group, including lymphocyte infection, chylous leakage, and bowel obstruction. Postoperative CT revealed reduced contrast in the lower pole of the right kidney in the 3DCT case with the most complex urinary vessel variations. Furthermore, in the 3DCT group, 8/34 (23.5%) unilateral or bilateral renal arteries were located caudally to the lower edge of the renal vein.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In gynecological malignancies, 3DCT before para-aortic lymphadenectomy seems superior in identifying urinary vessel variations over conventional contrast-enhanced CT; thus, aiding realistic preoperative simulations and potentially reducing surgeons' burden and perioperative complications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asia Oceania Federartion of Obstetrics and Gynaecocoly recommendation on the use of heat-stable carbetocin in the prevention of postpartum hemorrhage","authors":"U. D. P. Ratnasiri,&nbsp;Pisake Lumbiginon,&nbsp;Rohana Hattotuwa,&nbsp;John Tait,&nbsp;Krishnendu Gupta","doi":"10.1111/jog.16366","DOIUrl":"https://doi.org/10.1111/jog.16366","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular leiomyoma: A 10-year retrospective analysis of clinical features, and recurrence risk","authors":"Yang Ming,&nbsp;Ting Liang,&nbsp;Lu Wang,&nbsp;Duosheng Jiang,&nbsp;Tongfu Feng","doi":"10.1111/jog.16359","DOIUrl":"https://doi.org/10.1111/jog.16359","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>In this study, we aimed to compare the clinical characteristics of cellular leiomyoma (CL) with those of typical uterine leiomyoma (UL) and explore recurrence risk factors in patients with CL myomectomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Study Design</h3>\u0000 \u0000 <p>In this retrospective cohort study, we analyzed medical records of patients diagnosed with CL (<i>n</i> = 102) and UL (<i>n</i> = 105) who underwent surgery between January 2013 and May 2023. Postoperative prognosis was assessed through patient follow-up until June 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients with CL were likelier to have adenomyosis (odds ratio [OR], 4.06; 95% confidence interval [CI], 1.28–12.88; <i>p</i> = 0.017) and late-age menarche (OR, 1.50; 95% CI, 1.15–1.95; <i>p</i> = 0.002). A uterus that has three or fewer fibroids (OR, 2.14; 95% CI, 1.05–4.37; <i>p</i> = 0.037) was more likely to develop into CL than the control group. Concerning the predictive aspect, more than three fibroids are associated with a higher risk of recurrence (OR, 5.33; 95% CI, 1.02–27.76; <i>p</i> = 0.047). The use of hysteroscopy to remove submucosal fibroids is associated with a lower risk (OR, 0.08; 95% CI, 0.01–0.78; <i>p</i> = 0.030).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study confirms that CL exhibits distinct clinical characteristics from ULs, with a higher postoperative recurrence rate and risks of malignant transformation and abdominal dissemination. Our study identified for the first time that adenomyosis is an independent risk factor for CL. Additionally, submucous fibroids tend to be resected while still small, allowing for more complete removal and reducing recurrence risk. An increased number of fibroids was also identified as a risk factor for recurrence.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on the impact of intravenous remifentanil used for labor analgesia on parturient women and infants","authors":"Lingfei Pu,&nbsp;jia Lou,&nbsp;Mochi Guo","doi":"10.1111/jog.16365","DOIUrl":"https://doi.org/10.1111/jog.16365","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Remifentanil's safety in labor analgesia is as yet unknown, despite its special pharmacological characteristics, which include a strong analgesic impact, quick onset, and brief duration of action. This paper aims to offer a thorough analysis of the effects on pregnant women and infants of intravenous remifentanil used for labor analgesia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Based on the literature, the study divides the maternal system into many systems and discusses the effects of remifentanil on each. In contrast to the use of remifentanil during a general anesthesia cesarean delivery, we show the effects of an intravenous remifentanil analgesia pump on infants. Instead of making broad generalizations, we describe how different analgesic pump modes may influence maternal pain control.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Remifentanil's favorable benefits on the mother are mostly focused on pain control and the labor process, whereas its negative effects are primarily focused on the influence on breathing and sedation levels. Currently, it is widely regarded to have no substantial effect on the cardiovascular system. It is widely regarded as safe for infants, and current study focuses on its short-term effects on them. Of course, the setting of the analgesic pump plays a vital part in the whole process.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>As an alternative to labor analgesia, remifentanil can be used. However, to prevent its harmful effects on expectant mothers and newborns, we advise adopting some safety measures.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncommon postpartum delayed hemolytic transfusion reaction caused by anti-C antibodies: A rare presentation without prior risk factors","authors":"Takehiko Mitsuyama,&nbsp;Saki Takahashi,&nbsp;Emi Kondo,&nbsp;Toshitaka Mutoh,&nbsp;Kosuke Kawakami,&nbsp;Toshiyuki Yoshizato","doi":"10.1111/jog.16362","DOIUrl":"https://doi.org/10.1111/jog.16362","url":null,"abstract":"<p>Delayed hemolytic transfusion reaction (DHTR) is a rare post-transfusion complication, typically involving extravascular hemolysis. We present an unusual case of postpartum DHTR caused by anti-C antibodies in a 35-year-old Japanese woman, gravida 2, para 1, with no history of transfusion, alloimmunization, or underlying hemoglobinopathy. The patient developed dark-colored urine on postpartum day 25, 12 days after receiving a blood transfusion for hemorrhage due to placenta accreta spectrum. Laboratory findings revealed indirect hyperbilirubinemia, elevated lactate dehydrogenase, low haptoglobin, and hemoglobinuria, indicating concurrent extravascular and intravascular hemolysis. DHTR was confirmed by the detection of anti-C antibodies and the presence of C-antigen-positive transfused red cells. Maternal sensitization likely resulted from subclinical fetomaternal transfusion, with an immune response triggered post-transfusion. This case highlights the diagnostic challenges of DHTR in the postpartum setting, emphasizing the importance of post-transfusion antibody screening and the need for heightened awareness of unexplained fever as a potential early indicator.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}