Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Maternal and perinatal outcomes of birth center births compared to planned home births: A nation-wide, propensity-matched analysis","authors":"Madeline Burt,&nbsp;Dmitry Tumin,&nbsp;Neill Bates,&nbsp;Kerianne Crockett,&nbsp;James L. Whiteside","doi":"10.1111/jog.16329","DOIUrl":"https://doi.org/10.1111/jog.16329","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Rates of community births, including home and birth center births, have steadily increased in recent decades. Safety outcomes of community births have primarily been compared to hospital births. This study compares maternal and infant morbidity between birth centers and home births in the United States.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We identified planned home births and birth center births in 2016–2021 using the Centers for Disease Control and Prevention National Vital Statistics System. We used propensity score matching to compare each birth center birth to the most similar home birth, with outcomes including maternal and neonatal adverse events recorded on the birth certificate.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified 262 954 community births (42% in birth centers; 4% involving maternal or infant morbidity). After propensity score matching, we analyzed outcomes in a sample of 97 759 pairs of birth center births matched to planned home births. In the matched sample, maternal and infant morbidity was more likely in birth center births than in home births (odds ratio [OR]: 1.13, 95% confidence interval [CI]: 1.08–1.18). This difference was primarily due to higher maternal morbidity at birth centers (OR 1.57, 95% CI 1.44–1.71), with the largest difference seen for severe perineal trauma. Overall infant morbidity did not differ significantly between the two settings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In the United States, planned birth center births have higher rates of maternal morbidity than planned home births, mostly due to higher rates of severe perineal trauma. These data could support informed choice of community birth settings for patients considering home birth or birth at a birth center.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of knowledge, not vaccine hesitancy, is the main cause of low human papilloma virus vaccination rate among systemic lupus erythematosus patients in Japan after suspension of proactive recommendation: Analysis of a patients' survey","authors":"Takashi Kurita,&nbsp;Akio Yamamoto,&nbsp;Tadashi Hosoya,&nbsp;Marina Tsuchida,&nbsp;Shinsuke Yasuda,&nbsp;Yoshiaki Gu","doi":"10.1111/jog.16330","DOIUrl":"https://doi.org/10.1111/jog.16330","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To identify the factors that inhibit human papilloma virus (HPV) vaccination to improve the high HPV infection rate and cervical cancer incidence among SLE patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a questionnaire survey of female SLE patients aged 18–45 years attending our hospital to analyze factors related to HPV vaccination.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We obtained responses of 88 participants. Only 5 (5.7%) were received HPV vaccination, 15 (17.0%) were uncertain of their vaccine history, and 27 (30.7%) had never even heard of HPV vaccination. The reasons for unvaccinated against HPV were “don't know” with 24 participants, “missed opportunity” with 15, and “troublesome, somehow” with 8. The most trusted source of medical information for the unvaccinated was their physician (69, 60.2%). Among the unvaccinated, those who wished to be vaccinated in the future were positively correlated with “trust of vaccine benefit” (<i>r</i> = 0.561, <i>p</i> = 0.005) and “general knowledge about HPV vaccine” (<i>r</i> = 0.512, <i>p</i> = 0.013), and negatively correlated with “negative attitudes toward vaccination and vaccine policy” (<i>r</i> = −0.547, <i>p</i> = 0.007).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>HPV vaccination rate among SLE patients in Japan was extremely low. The main reason was lack of knowledge. The most effective solution is considered to provide accurate information and adequate recommendations of HPV vaccination by attending physicians.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16330","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A risk nomogram for assessing complications in patients undergoing surgical procedures for cervical cancer. Does baseline quality of life play a role?","authors":"Jorge Cea García,&nbsp;Inmaculada Rodríguez Jiménez,&nbsp;Laura Ríos-Pena,&nbsp;M. Carmen Rubio Rodríguez,&nbsp;Francisco Márquez Maraver","doi":"10.1111/jog.16318","DOIUrl":"https://doi.org/10.1111/jog.16318","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Surgery for cervical cancer is a known risk factor for hospital readmission, often due to urological, lymphovascular, or neurological complications. While comorbidities are commonly used to assess surgical risk, patient-reported measures like baseline quality of life (QoL) may also help predict complications. This study aimed to estimate how often surgical complications occur and what factors predict them, with a focus on baseline QoL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a prospective observational study of 100 cervical cancer patients who had surgery at a tertiary hospital between January 2010 and January 2019. A binary logistic regression model was used to predict surgical complications. Baseline QoL was measured with the Functional Assessment Cancer Therapy-cervix questionnaire. Data were analyzed using R software.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Surgical complications occurred in 54% of patients, most of them after surgery. There was no significant difference in QoL scores between patients with and without complications (<i>p</i> = 0.753). The prediction model showed good calibration (Hosmer–Lemeshow <i>p</i> = 0.999), no multicollinearity (variance inflation factor = 1.01), and moderate accuracy (<i>C</i>-index = 0.67). A history of cesarean section and pelvic lymphadenectomy was significant predictors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Surgical complications were common in this group. Cesarean section history and pelvic lymphadenectomy were linked to a higher risk. However, baseline QoL did not predict complications. Further research is needed to test this model in other patient groups.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the relationship between fertility health knowledge and healthy lifestyle behaviors among adult women and men","authors":"Ebru Cirban-Ekrem","doi":"10.1111/jog.16320","DOIUrl":"https://doi.org/10.1111/jog.16320","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aims to determine the relationship between fertility health knowledge and healthy lifestyle behaviors in adult women and men.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>It is a cross-sectional, relationship-seeking type. The research was completed with 1417 participants (921 female, 496 male) of active reproductive age living in Turkey. Data were collected online using the snowball sampling method between August 2023 and January 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The women who participated in the study answered 75.620% of the Fertility Health Knowledge Survey (FHKS) correctly, and their Healthy Lifestyle Behaviors Scale (HLBS)-II mean score was 123.865 ± 21.552. The men answered 68.770% of the FHKS correctly, and their HLBS-II mean score was 123.746 ± 21.077. A significant relationship was found between the participants' FHKS and HLBS-II scores. Healthy lifestyle behaviors explained 14% of the total variance in fertility health knowledge in women and 4.3% in men.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Participants exhibited fertility health knowledge and healthy lifestyle behaviors above the mean. It was determined that healthy lifestyle behaviors are a significant determinant of fertility health knowledge.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the attitudes of women who have undergone NIPT toward prenatal testing: The impact of the introduction of the prenatal testing certification system in Japan","authors":"Takeshi Nakamura,&nbsp;Nahoko Shirato,&nbsp;Tatsuko Ishii,&nbsp;Keiko Koide,&nbsp;Keiko Miyagami,&nbsp;Takahiro Yamada,&nbsp;Akihiko Sekizawa","doi":"10.1111/jog.16324","DOIUrl":"https://doi.org/10.1111/jog.16324","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>We compared changes in the perceptions of non-invasive prenatal testing (NIPT) before and after the introduction of a government-involved NIPT certification system in July 2022.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Web-based surveys of pregnant women who underwent NIPT were conducted in 2020 (pre-certification) and 2023 (post-certification) using a pregnancy-related mobile application.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We obtained 1198 and 1227 responses from the 2020 and 2023 surveys, respectively. Compared with 2020 respondents, 2023 respondents who chose non-certified facilities emphasized word-of-mouth reputation, online appointment availability, expanded testing beyond the three major trisomies, low cost, and improved accessibility. The two survey years showed no significant differences in overall trends in facility selection and the tendency to choose certified facilities to prioritize recommendations from their primary care physicians and the availability of pre-test genetic counseling. Additionally, when NIPT results were non-negative, respondents tested at non-certified facilities in 2023 were more likely to report concerns such as “insufficient explanation increased my anxiety” and “I regretted my choice of testing facility.” More respondents in 2023 preferred to undergo NIPT at facilities that provide routine prenatal checkups and believed each pregnant woman should make testing decisions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>After introducing the NIPT certification system, those choosing to undergo testing at certified facilities emphasized the importance of comprehensive support, whereas those opting for non-certified facilities prioritized convenience. However, the latter group became increasingly aware of the lack of post-test support when faced with non-negative results.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premature mortality due to cervical and ovarian cancers in Japan, 2000 to 2020","authors":"Duc-Cuong Le,&nbsp;Truong-Minh Pham,&nbsp;Pham Nguyen Quy,&nbsp;Junzo Hamanishi,&nbsp;Thi Thu Huong Le,&nbsp;Alysha Crocker,&nbsp;Jingyu Bu,&nbsp;Tatsuhiko Kubo","doi":"10.1111/jog.16327","DOIUrl":"https://doi.org/10.1111/jog.16327","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Using the national Japanese mortality data, we investigated whether there has been an improvement in the lifespan among Japanese women who died from cervical and ovarian cancers from the years 2000 through 2020.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The number of deaths due to cervical and ovarian cancers in Japan was obtained from the World Health Organization mortality database. We calculated age standardized rates (ASR) using the direct method adjusted to the World Standard Population. Years of life lost (YLL) due to those cancers were calculated using Japanese life tables. Average lifespan shortened (ALSS) measure was calculated as a ratio of YLL to the expected lifespan. We used the bootstrap method to calculate the 95% confidence interval (95% CI) for the ALSS measure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The ASR for death remained mostly stable over the study at about two deaths per 100 000 women for cervical cancer, and three deaths for ovarian cancer. The ALSS values report that women who died from cervical cancer lost on average 28.3% of their lifespan (95% CI: 27.7–28.9) in 2000 and 26.6% (26.1–27.2) in 2020. Women who died from ovarian cancer lost on average 26.9% (26.5–27.4) and 23.5% (23.1–23.9) of their lifespan in 2000 and 2020, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The ALSS results show that over a 20-year period, women who died of cervical and ovary cancers in Japan had their lifespans prolonged by about two and three percentage points, respectively.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent chemoradiotherapy for advanced cervical cancer during second trimester pregnancy: A case report","authors":"Taichi Minakawa,&nbsp;Ayako Nozaki,&nbsp;Tetsuya Nakajin,&nbsp;Kenrokuro Mitsube","doi":"10.1111/jog.16326","DOIUrl":"https://doi.org/10.1111/jog.16326","url":null,"abstract":"<p>In Japan, pregnancies complicated by cervical cancer are rising due to the higher incidence of cervical cancer among younger women, coupled with an increase in maternal age. Evidence regarding the treatment of cervical cancer during pregnancy is limited, especially for advanced cases that cannot be managed surgically. We present a case of stage IIIC1r cervical cancer in a 30-year-old woman, in which concurrent chemoradiotherapy (CCRT) was initiated at 15 weeks of gestation, with the fetus remaining in utero. Intrauterine fetal death was confirmed on the 21st day of treatment, and the fetus was delivered at 38 days. The patient completed CCRT with minimal delay and achieved complete tumor remission, with no recurrence observed at 1 year. This case also highlights the importance of early multidisciplinary intervention.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A live birth after bilateral salpingo-oophorectomy for seromucinous borderline ovarian tumor","authors":"Kyota Saito,&nbsp;Tatsuya Ishiguro,&nbsp;Yukina Kitazawa,&nbsp;Eri Shibaoka,&nbsp;Kaoru Yamawaki,&nbsp;Sosuke Adachi,&nbsp;Osamu Arakawa,&nbsp;Kosuke Yoshihara","doi":"10.1111/jog.16323","DOIUrl":"https://doi.org/10.1111/jog.16323","url":null,"abstract":"<p>Borderline ovarian tumors primarily affect younger women and are associated with favorable prognosis, making fertility-sparing surgery a viable option. However, owing to recurrence and malignant transformation risks, careful monitoring is required. Seromucinous borderline ovarian tumors, a rare subtype that is often associated with endometriosis, lack standardized guidelines for fertility-sparing surgery or infertility management following bilateral salpingo-oophorectomy with uterine preservation. We present a case of bilateral seromucinous borderline ovarian tumors stage IC3 managed with bilateral salpingo-oophorectomy, without observed recurrence, resulting in a live birth after frozen–thawed embryo transfer using embryos preserved before surgery. This case highlights the feasibility of bilateral salpingo-oophorectomy with uterine preservation and hormone replacement therapy-assisted frozen–thawed embryo transfer for seromucinous borderline ovarian tumors, emphasizing the importance of long-term surveillance and multidisciplinary management. Further research is required to establish evidence-based guidelines for seromucinous borderline ovarian tumor treatment and infertility care post-bilateral salpingo-oophorectomy.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy outcomes in women with different endometriosis lesion types: A review of current evidence","authors":"Hrishikesh Munshi,&nbsp;Nayna Barada,&nbsp;Sandhya Anand,&nbsp;Rahul K. Gajbhiye","doi":"10.1111/jog.16321","DOIUrl":"https://doi.org/10.1111/jog.16321","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Endometriosis, affecting ~10% of women of reproductive age, is associated with infertility and adverse pregnancy outcomes. The condition is classified into superficial peritoneal endometriosis (SUP), ovarian endometriomas (OMA), and deep infiltrating endometriosis (DIE), with varying impacts on pregnancy. This review examines the relationship between lesion subtypes and adverse maternal–fetal outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive literature search was conducted using PubMed, Scopus, Google Scholar, and Web of Science. Studies published between 2014 and 2025 that investigated pregnancy outcomes in women with endometriosis were included. Articles were screened based on predefined inclusion criteria, with 10 studies meeting the final selection. Outcomes analyzed included placenta previa, preterm birth, stillbirth, pre-eclampsia, intrauterine growth restriction (IUGR), and miscarriage.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Women with endometriosis exhibited a significantly higher risk of placenta previa, particularly those with Stages III–IV disease (<i>p</i> &lt; 0.05) and deep infiltrating lesions (<i>p</i> &lt; 0.05). The risk was further elevated in pregnancies conceived via assisted reproductive technologies (ART) (<i>p</i> = 0.01). The likelihood of preterm birth was higher in patients with bladder DIE (<i>p</i> = 0.02) and rectal DIE (<i>p</i> = 0.01), but not in those with ovarian endometriomas. Meta-analysis data indicated a moderate association between endometriosis and pre-eclampsia (<i>p</i> &lt; 0.05), particularly in patients with deep lesions (<i>p</i> = 0.03). Stillbirth risk showed inconsistent findings, with some studies reporting an increased risk (<i>p</i> &lt; 0.05) while others found no significant association. IUGR and small-for-gestational-age (SGA) infants were more common in women with DIE (<i>p</i> = 0.03) and advanced-stage disease (<i>p</i> = 0.05). Miscarriage risk was elevated in patients with superficial endometriosis (<i>p</i> &lt; 0.05) compared with those with DIE or OMA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Endometriosis, particularly ovarian and deep infiltrating, significantly increases the risk of placenta previa, preterm birth, IUGR, and miscarriage. ART conception further amplifies these risks. While conflicting evidence exists for stillbirth and pre-eclampsia, lesion-specific trends suggest a need for individualized obstetric management. Larger studies are required to clarify these associations and optimize pregnancy care for affected women.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of intraovarian versus subcutaneous corifollitropin alfa administration in DuoStim protocol for infertile women with low in vitro fertilization response","authors":"Fatemeh Keikha,&nbsp;Firoozeh Rakhshani Moghadam,&nbsp;Seyedeh Shahed Shoarishoar,&nbsp;Azadeh Tarafdari,&nbsp;Marjan Ghaemi","doi":"10.1111/jog.16316","DOIUrl":"https://doi.org/10.1111/jog.16316","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>Infertility in women, particularly those with a poor response to in vitro fertilization (IVF), poses significant challenges in reproductive medicine. This study aimed to compare the effectiveness of intraovarian versus subcutaneous injection of corifollitropin alfa in the DuoStim protocol among infertile women exhibiting a poor response to IVF, with a specific focus on oocyte retrieval counts and quality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A total of 40 poorly responding infertile women were randomly assigned to two groups: 20 women received corifollitropin alfa via intraovarian injection, and 20 women received it via subcutaneous injection. Key demographic data, cycle duration, gonadotropin dosage, the number of oocytes retrieved, and oocyte quality (specifically Grade B oocytes) were assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Demographic analyses revealed no significant differences between the two groups in terms of age (subcutaneous: 37.91 ± 6.11 years; intraovarian: 36.84 ± 5.42 years; <i>p</i> = 0.17) or weight (subcutaneous: 74.15 ± 10.51 kg; intraovarian: 78.24 ± 13.22 kg; <i>p</i> = 0.42). The number of oocytes retrieved during both phases did not significantly differ, but the intraovarian group yielded a notably higher number of Grade B oocytes during the follicular phase (<i>p</i> = 0.02). No significant differences were observed in cycle duration (<i>p</i> &gt; 0.05) or the final dose of gonadotropins administered (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study revealed that intraovarian injection of corifollitropin alfa may enhance the quality of oocytes retrieved, particularly Grade B oocytes, in women with poor response to IVF under the DuoStim protocol, while both methods exhibited similar outcomes in terms of demographic factors, cycle duration, and gonadotropin dosage.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}