Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Prevalence and predictors of vaginal douching among pregnant women","authors":"Pınar Kara","doi":"10.1111/jog.16286","DOIUrl":"https://doi.org/10.1111/jog.16286","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to determine the prevalence of vaginal douching and its predictors among pregnant women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional and multi-center study was conducted from March to November 2024, involving 1523 pregnant women receiving routine antenatal care at four government hospital obstetric outpatient clinics. Data were collected using a structured questionnaire addressing personal and vaginal douching practices. Statistical analyses were performed at a significance level of <i>p</i> &lt; 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The prevalence of vaginal douching among the participants was 30.7%. The primary motivation for vaginal douching was personal hygiene, with water being the most frequently used substance. Information about the practice was predominantly obtained from family elders, friends, or individual experience. Misconceptions regarding the hygienic and health implications of vaginal douching were prevalent among participants. Despite awareness of its association with genital infections or related problems, many participants continued the practice. Multiple logistic regression analysis identified significant predictors of vaginal douching, including perceptions that it is hygienic, healthy, and associated with risks of genital infections/problems; a history of genital infections/problems within the previous year; receiving information about vaginal douching from family elders; engaging in sexual intercourse 1–2 times per week during the current pregnancy; being in the third trimester; being unemployed; and having completed secondary or high school education. The independent variables accounted for 73.9% of the variance in the dependent variable (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study provides essential insights into the prevalence of vaginal douching among pregnant women and highlights their perceptions and motivations for engaging in this practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between loneliness perception and breastfeeding self-efficacy and breastfeeding behaviors in mothers","authors":"Rukiye Demir,&nbsp;Resmiye Kaya Odabaş,&nbsp;Ayten Taşpınar","doi":"10.1111/jog.16280","DOIUrl":"https://doi.org/10.1111/jog.16280","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Breast milk and breastfeeding affect the health of the child, the mother, and indirectly the public. Therefore, it is important to determine the breastfeeding self-efficacy of mothers, breastfeeding behaviors, and the factors affecting them, and to eliminate the factors that negatively affect breastfeeding.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The study was conducted to examine the relationship between the perception of loneliness in mothers and breastfeeding self-efficacy and breastfeeding behaviors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This descriptive and correlational study was conducted in Turkey between March and November 2024 with 382 mothers (<i>n</i> = 382). The data were collected using the Descriptive Information Form, Breastfeeding Self-Efficacy Scale (BSES), and Social and Emotional Loneliness Scale (SELSA-S).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean total score of the mothers in the study was 43.72 ± 11.13 and the mean total score of SELSA-S was 59.67 ± 13.25. In the study, it was found that those who were university graduates, were employed, received education about breastfeeding, were currently breastfeeding, as well as those who exclusively breastfed for the first 6 months, received spousal support while breastfeeding, had statistically significantly higher mean total scores on the BSES and lower mean total scores on the SELSA-S than the others. Additionally, receiving general social support and specifically from their spouses also contributed to these higher scores. In addition, a high-level negative linear relationship was found between the BSES and SELSA-S total and sub-dimensions (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>It was concluded that the perception of social and emotional loneliness negatively affected breastfeeding self-efficacy and some breastfeeding behaviors in mothers with infants aged 0–24 months.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive value of triglyceride-glucose index, lipid accumulation product and lipid ratio on metabolic syndrome in polycystic ovary syndrome patients","authors":"Ning Ma,&nbsp;Xiao-Ning Cui,&nbsp;Na Wang","doi":"10.1111/jog.16283","DOIUrl":"https://doi.org/10.1111/jog.16283","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To identify reliable indicators to predict the occurrence of metabolic syndrome (MetS) and to provide an effective way to prevent it in polycystic ovary syndrome (PCOS), we explored the relationships between triglyceride-glucose index (Ty-G), lipid accumulation product (LAP), lipid accumulation product ratio, and MetS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We detected the relationship between the Ty-G index, LAP, lipid ratio, and incidence of MetS. In addition, we classified the Ty-G index and LAP into tertiles to determine the efficacy of these indicators in predicting the risk of MetS. Finally, the effects of the Ty-G index, LAP, and lipid ratio on the prediction of MetS were evaluated with the receiver operating characteristic (ROC) curve.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our results indicate that the incidence of MetS was 38% in 134 patients with PCOS, and that the Ty-G index, LAP, and lipid ratio were independent risk factors for MetS. In addition, the incidence of MetS significantly increased with Ty-G index and LAP. The ROC curve showed that the Ty-G index, LAP, and lipid ratio all showed good performance in predicting the occurrence of MetS in PCOS patients, but the Ty-G index had the highest predictive value, with a cut-off value of 8.70.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study revealed that the Ty-G index plays an important role in predicting the occurrence of MetS in PCOS patients. In addition, monitoring blood glucose and lipid levels is an effective approach for preventing MetS in PCOS patients clinically regardless of age, and weight management should be strictly implemented in overweight and obese patients to prevent MetS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of erector spinae plane block and transversus abdominis plane block on quality of recovery and postoperative pain after laparoscopic hysterectomy; randomized, double-blinded clinical trial","authors":"Pelin Dilsiz,&nbsp;İsmail Gökbel,&nbsp;Yaşam Umutlu,&nbsp;Hüseyin Alp Ertuğrul,&nbsp;Sinem Sari","doi":"10.1111/jog.16284","DOIUrl":"https://doi.org/10.1111/jog.16284","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The erector spinae plane (ESP) block is used in various surgical procedures as an effective and safe regional analgesia technique. Unlike other plane blocks, the ESP block provides cutaneous and visceral analgesia by involving both ventral and dorsal roots. This study compared the ESP block and the transversus abdominis plane (TAP) block after laparoscopic hysterectomy, aiming primarily to compare quality of recovery (QoR) and secondarily to compare pain scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A prospective randomized controlled study involved 64 patients. After ethical approval and patient consent, patients undergoing elective laparoscopic hysterectomy were randomly assigned to two groups: Group E received a bilateral ESP block, and Group T received a bilateral lateral TAP block. In the recovery room, patients with a numerical rating score (NRS) of 4 or above received intravenous meperidine as rescue analgesia. The same postoperative analgesia plan was applied to all patients, including intravenous paracetamol and intramuscular diclofenac sodium. Tramadol was administered if the NRS score was 4 or above. Preoperative and postoperative QoR scores, pain scores, rescue analgesia use, nausea and vomiting, antiemetic use, unexpected side effects, mobilization time, and discharge time were recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>When comparing preoperative and postoperative QoR scores, it was found that the decreases in scores were less in Group E. NRS scores were lower at the 4th, 8th, 12th, and 16th hours in Group E. Mobilization times were also shorter in Group E.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The ESP block is more effective than the TAP block in improving the quality of recovery and pain scores after laparoscopic hysterectomy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to “Is it ethical to use ChatGPT to write scientific papers?”","authors":"Minna J. Hsu,&nbsp;Govindasamy Agoramoorthy","doi":"10.1111/jog.16274","DOIUrl":"https://doi.org/10.1111/jog.16274","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of miRNA polymorphisms on male and female infertility and recurrent implantation failure","authors":"Reza Alibakhshi,&nbsp;Masoud Soleimani,&nbsp;Kheirollah Yari,&nbsp;Amir Ali Kalhori,&nbsp;Mohsen Karami,&nbsp;Mohammad Reza Kalhori","doi":"10.1111/jog.16281","DOIUrl":"https://doi.org/10.1111/jog.16281","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>MiRNAs regulate gene expression, impacting reproductive health, such as infertility and implantation failure. This study investigated the association between miRNA polymorphisms and male infertility (azoospermia, oligospermia), female infertility (endometriosis), and recurrent implantation failure in IVF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In order to find relevant articles, a search was conducted in PubMed, WOS, Scopus, and the Cochrane Library databases using Mesh terms and Entry terms with the keywords (miRNA OR microRNA polymorphism) AND (abortion OR miscarriage OR infertility OR sterility OR pregnancy loss OR implantation failure).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study revealed miRNA polymorphisms linked to a higher risk of male and female infertility and repeated implantation failure in IVF. These results underscore the significance of genetic variations in miRNAs in developing reproductive issues and the promise of personalized treatment strategies guided by genetic profiles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These results provide valuable insights into the genetic basis of infertility and emphasize the need for further research to develop targeted diagnostic tools and therapies. Understanding the role of miRNA polymorphisms in reproductive health has significant implications for improving outcomes for couples struggling with infertility. By elucidating the genetic factors contributing to infertility, this study paves the way for personalized approaches to diagnosis and treatment, ultimately enhancing reproductive care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Situation of sexual and reproductive health and rights in Japan in comparison with the world","authors":"Hiromi Obara,&nbsp;Rei Haruyama,&nbsp;Sumiyo Okawa","doi":"10.1111/jog.16273","DOIUrl":"https://doi.org/10.1111/jog.16273","url":null,"abstract":"<p>Since the 1994 Cairo Conference, global efforts have focused on improving sexual and reproductive health and rights. This review examined the progress and challenges of the SRHR in Japan, comparing it with the global situation. SRHR indicators and situations were assessed using the United Nations Sustainable Development Goals' monitoring indicators and relevant reports. For the past two decades, Japan has consistently maintained the lowest maternal and neonatal mortality rates, as well as adolescent birth rates, globally. However, contraception-related indicators remain suboptimal and inadequately monitored at the national level. Although the percentage of unwanted pregnancies has decreased over time, unintended and unwanted pregnancies remain prevalent in Japan. Notably, adolescents (aged &lt;20 years) and youth (aged 20–24 years) accounted for over 33% of the total 126 734 induced abortions in 2023. The number of induced abortions among adolescents has consistently exceeded the number of live births in the same age group since the mid-1970s. In conclusion, key areas for further improvement in Japan include reducing unintended and unwanted pregnancies, improving contraception access and monitoring systems, and ensuring women's right to self-determination. As outlined by the Programme of Action of the Cairo Conference, appropriate information and means should be provided to support women and men, including adolescents and youths appropriately, in making informed decisions about their fertility. In collaboration with various health professionals and other sectors, obstetricians and gynecologists are expected to be more actively committed to improving SRHR in Japan and the world.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ubiquinol intake on improving menstrual symptoms among female healthcare workers: An open-label pilot study","authors":"Tetsu Kinoshita,&nbsp;Koutatsu Maruyama,&nbsp;Kikumi Katakami,&nbsp;Takayo Sakiyama","doi":"10.1111/jog.16279","DOIUrl":"https://doi.org/10.1111/jog.16279","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to investigate the effects of ubiquinol on menstrual symptoms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This open-label trial involved 86 female healthcare workers aged 21–48 years. The study design included an observation period and a ubiquinol intake period. During the intake period, the participants consumed two soft capsules containing 75 mg of ubiquinol daily (i.e., 150 mg/day). At baseline and after the observation and intake periods, the participants underwent blood testing and completed the Pittsburgh Sleep Quality Index to evaluate their sleep condition. In addition, the Menstrual Distress Questionnaire was completed before, during, and after each of the first seven menses. All statistical analyses were performed, stratified by the median age of the participants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Regarding the Menstrual Distress Questionnaire, in the younger group (age: &lt;36 years), a significant improvement was observed in menstrual “Control” (<i>p</i> = 0.049) by ubiquinol intake. In the older group (age: ≥36), the effects of ubiquinol on the improvement of premenstrual “Negative affect” and “Control” scores reached significance (<i>p</i> = 0.02 and <i>p</i> &lt; 0.01, respectively); further, menstrual “Control” score was significantly improved (<i>p</i> = 0.03). In addition, the Pittsburgh Sleep Quality Index showed a significant effect of ubiquinol in the older group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This pilot study indicated that ubiquinol alleviated menstrual symptoms among premenopausal female healthcare workers. In those aged ≥36 years, ubiquinol intake may reduce premenstrual irritability and improve sleep quality.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application value of routine office hysteroscopy prior in patients with one embryo transferred failure and normal transvaginal ultrasound","authors":"Hui-Juan Guan,&nbsp;Huai-Yun Tang,&nbsp;Hui Li,&nbsp;Jia-Hui Zhao,&nbsp;Jia Song,&nbsp;Li-Sha Tang","doi":"10.1111/jog.16267","DOIUrl":"https://doi.org/10.1111/jog.16267","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of our study was to investigate whether outpatient hysteroscopy performed in the month before starting an embryo transfer cycle in women who had experienced one failed in vitro fertilization treatment cycle could improve the treatment outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective analysis selected the patients who were failures after the first embryo transfer of good-quality embryos between January 2019 to February 2023; the women did not undergo hysteroscopy before IVF, and ultrasound did not observe the pathological abnormalities. A total of 199 patients were included for analysis, 119 females in the hysteroscopic group and 80 females in the controlled group. Women in the study group underwent hysteroscopic examination 3–7 days of the clean menstrual period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There was no statistically significant difference between the groups for demographic features and hysteroscopy cycle characteristics. The logistic regression analysis showed that performing hysteroscopy prior to patients who had one embryo transferred failure and normal transvaginal scan findings was not an influencing factor for live birth rate.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Performing diagnostic hysteroscopy in patients who had one embryo transfer failure and normal transvaginal scan findings did not improve fertility outcomes. Hence, routine usage of hysteroscopy should not be offered to patients who had one embryo transfer failure and without previously detected pathology of the uterine cavity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can fetal ultrasound predict adrenal hypoplasia congenita caused by Xp21 deletion?","authors":"Yuko Yokohama,&nbsp;Yoshio Makita,&nbsp;Yuriko Oishi,&nbsp;Ken Nagaya,&nbsp;Shigeru Suzuki,&nbsp;Yasuhito Kato","doi":"10.1111/jog.16276","DOIUrl":"https://doi.org/10.1111/jog.16276","url":null,"abstract":"<p>Xp21 deletion is a contiguous gene deletion syndrome characterized by adrenal hypoplasia congenita (AHC). If prenatal genetic diagnosis does not determine whether a male fetus at risk is affected, it is necessary to monitor him to diagnose adrenal insufficiency in the first few days of life to avoid a salt-losing adrenal crisis. Whether AHC can be diagnosed by prenatal ultrasound is not known. Ultrasound findings of fetal adrenal glands were compared between healthy and affected siblings whose mother was a carrier of the Xp21 deletion. The couple did not want an invasive prenatal diagnosis during either pregnancy. The adrenal glands of a healthy fetus have a two-layered structure, but this structure could not be confirmed in the affected male. We believe this is an important finding that suggests that steroid supplementation may be necessary immediately after birth.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}