Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Risk and survival of third primary cancers in a population-based cohort of patients with a cervical, endometrial, or ovarian cancer","authors":"Elisabete Gonçalves,&nbsp;Filipa Fontes,&nbsp;Jéssica Rocha Rodrigues,&nbsp;Rita Calisto,&nbsp;Maria José Bento,&nbsp;Nuno Lunet,&nbsp;Samantha Morais","doi":"10.1111/jog.16297","DOIUrl":"https://doi.org/10.1111/jog.16297","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Multiple primary cancers are relevant outcomes among survivors of gynecological cancers, contributing to the overall cancer burden and having a potential impact on the management of each primary cancer. This study aimed to estimate the risk and survival of third primary cancers (TPCs) among females with a cervical, endometrial, or ovarian first primary cancer (FPC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with a cervical, endometrial, or ovarian FPC from the Portuguese North Region Cancer Registry, diagnosed between 2000 and 2010 (<i>n</i> = 5846), were followed for a TPC (December 31, 2015) and death from any cause (December 31, 2023). The cumulative incidence of TPCs and mortality was estimated. Patients with a TPC were matched (1:1) to patients without a TPC (FPC + second primary cancer [SPC] only) to compare survival.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 29 (0.5% of FPCs and 5.4% of SPCs) TPCs were diagnosed. The most common sites were digestive organs (<i>n</i> = 9) followed by breast and urinary tract cancers (<i>n</i> = 4 each). Among all FPCs, the 10-year cumulative incidence (95% confidence interval [CI]) of a TPC was 0.5% (0.3%–0.7%) and among SPCs, it was 5.8% (3.3%–8.2%). For TPCs, compared to matched patients, the age-adjusted hazard ratio (95% CI) for death was 3.0 (1.39–6.50). The 10-year cumulative mortality of TPCs and matched patients was 75.7% and 42.0%, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In Northern Portugal, TPCs occurred mainly in digestive organs, followed by the breast and urinary tract, with a 10-year cumulative incidence of 0.5% among all FPCs. TPCs had a worse long-term survival compared to patients with an SPC only.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between serum and seminal vitamin D levels and sperm parameters","authors":"Goksun Ipek,&nbsp;Sezcan Mumusoglu,&nbsp;Gurkan Bozdag,&nbsp;Serdar Gunalp","doi":"10.1111/jog.16305","DOIUrl":"https://doi.org/10.1111/jog.16305","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To examine the association between serum/seminal plasma vitamin D levels and sperm parameters, the possible effects of serum/seminal vitamin D on sperm motility via seminal intracellular calcium measurement, and the antioxidant effect via malondialdehyde (MDA) measurement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective study was conducted on 87 male patients. Serum vitamin D levels of patients were evaluated and grouped based on their serum vitamin D levels: low (&lt;50 nmol/L), normal (50–75 nmol/L), and high (&gt;75 nmol/L). Sperm characteristics were evaluated. Seminal plasma vitamin D, intracellular calcium, and MDA concentrations were measured using Liquid Chromatography Mass Spectrometry (LC–MS/MS), High-performance liquid chromatography (HPLC), and fluorescence plate reader methods, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients with normal serum vitamin D levels had higher total progressive motile sperm concentrations (14.0 vs. 8.5 vs. 4 million/mL, <i>p</i> = 0.037) and higher normal sperm morphology (6% vs. 4% vs. 3%, <i>p</i> = 0.020) compared to those with low and high levels. No correlations were found between serum vitamin D levels and seminal vitamin D (<i>r</i> = 0.052, <i>p</i> = 0.468), MDA (<i>r</i> = −0.048, <i>p</i> = 0.791), and intracellular calcium levels (<i>r</i> = 0.064, <i>p</i> = 0.929). Seminal intracellular calcium levels were significantly correlated with total (<i>r</i> = 0.241, <i>p</i> = 0.024) and progressive (<i>r</i> = 0.217, <i>p</i> = 0.043) sperm motility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>There were positive correlations between serum vitamin D levels, total progressive motile sperm concentration, and normal sperm morphology. However, serum vitamin D levels were not correlated with seminal vitamin D levels and showed no correlations with potential mechanisms of action, reflected by intracellular calcium and MDA concentrations. Conversely, intracellular calcium levels were positively correlated with both total and progressive sperm motility, suggesting that intracellular calcium plays an essential role in sperm motility.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Exenatide plus Metformin versus Metformin alone on insulin resistance in women with Polycystic Ovary Syndrome: A systematic review and meta-analysis","authors":"Abd-alrahman Al-Qudah,&nbsp;Mohammad Al-Hanaktah,&nbsp;Reham Albadaineh","doi":"10.1111/jog.16296","DOIUrl":"https://doi.org/10.1111/jog.16296","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Polycystic ovary syndrome (PCOS) is a common endocrine disorder among reproductive-age women, often accompanied by insulin resistance, obesity, and increased metabolic risk. While Metformin (MET) is commonly used to improve insulin sensitivity, its limited effect on postprandial glucose has led to interest in combination therapies. Exenatide (EX), a glucagon-like peptide-1 receptor agonist, may offer complementary benefits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To assess the effectiveness of EX combined with MET (EX + MET) versus MET alone (MET) in improving insulin resistance and metabolic outcomes in overweight and obese women with PCOS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This systematic review and meta-analysis included five randomized controlled trials (<i>n</i> = 339) and followed Preferred Reporting Items for Systematic reviews and Meta-Analysis Extension guidelines. The primary outcome was the change in insulin resistance (Homeostatic Model Assessment of Insulin Resistance [HOMA-IR]). Secondary outcomes included body mass index (BMI), 2-h oral glucose tolerance test (OGTT), lipid profile, and reproductive hormones.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Pooled analysis revealed that EX + MET significantly reduced HOMA-IR (mean difference [MD]: –0.9; <i>p</i> &lt; 0.001), improved 2-h OGTT values (MD: –1.78; <i>p</i> &lt; 0.001), reduced BMI (MD: –0.4; <i>p</i> = 0.03), with low heterogeneity. Combination therapy also improved triglyceride and total cholesterol levels. However, no significant effects were observed on reproductive hormones or low-density lipoprotein and high-density lipoprotein cholesterol.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>While hormonal and some lipid changes were not significant, their inclusion highlights the multifaceted impact of PCOS and the need for longer-term studies. By improving insulin sensitivity and weight-related outcomes, EX + MET may be a valuable clinical option for metabolically high-risk PCOS patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship of marital adjustment with mothers' postpartum comfort and adjustment to the postpartum period in Turkiye: A cross-sectional study","authors":"Rukiye Demir,&nbsp;Pelin Akçar","doi":"10.1111/jog.16293","DOIUrl":"https://doi.org/10.1111/jog.16293","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of this study is to examine the relationship between marital adjustment and mothers' postpartum comfort and adjustment to the postpartum period in Turkiye.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The cross-sectional study was conducted in a public hospital in Turkey between October 2023 and 2024. The population of the study consisted of women who gave birth in this hospital between the dates of the study, and the sample consisted of 200 women (<i>n</i> = 200). The data were collected through face-to-face interviews using the personal information form, marital adjustment scale, postpartum comfort scale, and postpartum self-assessment scale.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean total score of the mothers who participated in the study was 41.78 ± 7.96 on the Marital Adjustment Scale [MAS], 174.08 ± 11.80 on the Postpartum Comfort Scale (PCS), and 100.12 ± 3.62 on the Postpartum Self-Assessment Scale. It was determined that the mean total scores of the mothers with high mean total scores on the MAS were higher (186.06 ± 7.53 and 129.28 ± 5.38, respectively) than those with low mean total scores on the MAS (154.16 ± 10.83 and 96.28 ± 3.62, respectively) (<i>p</i> &lt; 0.05). A strong positive correlation was found between the mothers' MAS and PCS and PSAS (<i>r</i> = 0.542, <i>p</i> = 0.000 and <i>r</i> = 0.234, <i>p</i> = 0.021, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In the study, it was concluded that marital adjustment increased the postpartum comfort level of mothers and their adaptation to this period.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of local vasopressin injection and vaginal evacuation for cesarean scar pregnancy: A retrospective review of 11 cases","authors":"Hiroshi Ishikawa,&nbsp;Yuki Goto,&nbsp;Chigusa Hirooka,&nbsp;Eri Katayama,&nbsp;Nao Baba,&nbsp;Yoshiko Saito,&nbsp;Meika Kaneko,&nbsp;Kaori Koga","doi":"10.1111/jog.16306","DOIUrl":"https://doi.org/10.1111/jog.16306","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Vaginal removal of cesarean scar pregnancy (CSP) carries the risk of massive bleeding and residual gestational tissue. To address these complications, we administered local injections of diluted vasopressin surrounding the gestational tissue before vaginal evacuation. In this study, we investigated the surgical and subsequent reproductive outcomes of patients with CSP treated using this technique.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed 11 patients between January 2014 and December 2023, for whom the above technique was used to manage cases in which gestational tissue did not bulge on the bladder side. We injected 5–10 mL of vasopressin diluted 100 times with saline surrounding the gestational sac under transvaginal ultrasound guidance and performed vaginal evacuation either electronically or manually.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median (range) age, body mass index, and gestational week at surgery were 35 (27–43) years, 26.0 (21.5–33.0) kg/m², and 6 (5–8) weeks of gestation, respectively. The longest diameter of the gestational sac was 9.7 (6.5–19.4) mm, and serum human chorionic gonadotropin level at vaginal evacuation was 6327 (1284–14 446) mIU/mL. Surgeries were completed in 17 (10–18) min with minimal blood loss and no residual tissue. Five of the 10 patients who wished for a subsequent pregnancy conceived successfully, and three patients had term deliveries. One patient with a T-shaped uterine cavity experienced recurrent CSP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Local injection of diluted vasopressin and vaginal evacuation is safe and easy without critical adverse events in patients with CSP, where the gestational tissue is not bulging toward the bladder.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NINJ1 exerts a role in the development of preeclampsia through potential regulation by the Notch1 signaling pathway","authors":"Qin Shi,&nbsp;Panyun Gu,&nbsp;Yi Tang,&nbsp;Qianqian Ma,&nbsp;Yunzhao Xu","doi":"10.1111/jog.16295","DOIUrl":"https://doi.org/10.1111/jog.16295","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To explore NINJ1 expression in the placental tissue of preeclampsia patients, its correlation with patient status and pregnancy outcome, and offer preliminary insights into the relationship between NINJ1 and the Notch1 signaling pathway.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Placental tissue samples from PE and normal pregnancies were collected. NINJ1 expression was detected and compared between groups. Correlation with clinical data was analyzed. A PE cell model was established using hypoxia-treated cells. The Notch pathway inhibitor DAPT was used. Additionally, trophoblast cells were treated with different concentrations of the Notch pathway inhibitor DAPT. The CCK-8 assay and scratch test were used to assess cell proliferation and migration. The levels of NINJ1 and Notch signaling components were measured using qRT-PCR and western blot.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>NINJ1 expression was higher in PE placental tissues compared to normal tissues. Women in the PE group had a higher incidence of hypoproteinemia, thoracoabdominal effusions, premature deliveries, and a higher hospitalization rate for newborns compared to the normal group. NINJ1 protein expression in the PE group placental tissues was negatively correlated with newborn birth weight and the serum albumin level and positively correlated with the 24-h urinary protein and uric acid levels. NINJ1 expression was increased in trophoblast cells under hypoxic conditions, while Notch signaling pathway inhibition reduced the proliferation and migration abilities of trophoblast cells, downregulated Notch1, Hes1, and Hes5 protein expression, and significantly upregulated NINJ1 expression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>High expression of NINJ1 is associated with the occurrence of preeclampsia and adverse pregnancy outcomes, potentially regulated by the Notch1 signaling pathway.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Letter to “Will the day come when opinion and letter pieces disappear from the medical journals?”","authors":"Shigeki Matsubara","doi":"10.1111/jog.16302","DOIUrl":"https://doi.org/10.1111/jog.16302","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in factors influencing specialty choice in obstetrics and gynecology: A national survey of graduating senior residents","authors":"Kyosuke Kamijo,&nbsp;Tokumasa Suemitsu,&nbsp;Masako Hayashi,&nbsp;Yuki Iida,&nbsp;Ayana Ogawa,&nbsp;Yoko Kashima,&nbsp;Yoko Aoyagi,&nbsp;Satoshi Takemori,&nbsp;Takuma Ohsuga,&nbsp;Kazutoshi Nakano,&nbsp;Yu Ito,&nbsp;Hiroaki Komatsu,&nbsp;Kaori Koga,&nbsp;Fuminori Taniguchi","doi":"10.1111/jog.16299","DOIUrl":"https://doi.org/10.1111/jog.16299","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To analyze gender differences in factors influencing the choice of obstetrics and gynecology as a specialty and to inform gender-specific recruitment strategies for a more diverse and sustainable obstetrics and gynecology workforce.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This nationwide cross-sectional survey was conducted annually in Japan from 2019 to 2024, targeting post-senior residency obstetricians and gynecologists. The survey collected data on demographics, timing, reasons for choosing obstetrics and gynecology, and changes in concerns from pre- to post-senior residency.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The survey received 2049 responses out of 2458 distributed surveys, resulting in a response rate of 83.9% (60.6% female, 39.4% male). Moreover, 52.4% of respondents initially considered obstetrics and gynecology during medical school, with females more likely to consider it before medical school than males (24.8% vs. 17.3%). Clinical clerkship experience was the most common reason (57.7%), particularly among females compared to males (62.3% vs. 50.5%). However, males were more influenced by family members or relatives (6.9% vs. 13.1%) and lectures (8.6% vs. 12.6%) than females. Pre-residency concerns—physical burden, mental burden, night on-call demands, marriage and family planning, career path planning, litigation risks, and workforce shortages—were higher in females than in males, although these concerns decreased significantly post-residency, excluding those regarding workforce shortages and income. Male-specific concern about the “need for male physicians” decreased significantly from 32.3% to 11.9%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This nationwide survey provides valuable insights into the role of gender in specialty decision-making, with important implications for developing gender-specific recruitment strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microdissection testicular sperm extraction in male partner with non-obstructive azoospermia: Fresh or frozen–thawed sperm for intracytoplasmic sperm injection?","authors":"Sevinc Özmen,&nbsp;Esra Nur Tola","doi":"10.1111/jog.16298","DOIUrl":"https://doi.org/10.1111/jog.16298","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To compare the outcomes of intracytoplasmic sperm injection (ICSI) of fresh and cryopreserved sperm obtained via microdissection testicular sperm extraction (micro-TESE) in cases of non-obstructive azoospermia (NOA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 147 patients with NOA who underwent micro-TESE and obtained viable sperm via micro-TESE at Istanbul Medipol In Vitro Fertilization unit were recruited retrospectively. The cases were divided into two groups depending on the sperm used (fresh or frozen–thawed) for ICSI: The micro-TESE group (<i>n</i> = 93) underwent ICSI cycles with fresh spermatozoa and the micro-TESE-Thaw group (<i>n</i> = 54) underwent ICSI cycles with cryopreserved spermatozoa. Patient demographics, embryo development, and pregnancy outcomes were compared between the two groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No statistical difference was observed between the two groups in terms of demographic features (age, body mass index, etc.) and cycle characteristics (induction protocol, gonadotropin dose, etc.). Fertilization rates and embryo quality were also similar between the groups. Higher clinical pregnancy and live birth rates were observed in the micro-TESE group than in the micro-TESE-Thaw group (<i>p</i> &lt;0.04 and <i>p</i> &lt;0.003, respectively). The miscarriage rate was higher in the micro-TESE-Thaw group, although the difference did not reach statistical significance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion(s)</h3>\u0000 \u0000 <p>In cases where frozen sperm obtained by micro-TESE are used, even if viable and motile sperm are found after thawing, there may be a negative impact on the ICSI result. Fresh testicular spermatozoa appear to result in better clinical pregnancy and live birth rates than cryopreserved testicular spermatozoa in males with NOA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The persistence of HPV type-specific infections in patients following colposcopic examination: An observational study","authors":"Serkan Akis,&nbsp;Canan Kabaca,&nbsp;Yunus Emre Purut,&nbsp;Esra Keles,&nbsp;Ugur Kemal Ozturk,&nbsp;Mine Guray Uzun,&nbsp;Murat Api","doi":"10.1111/jog.16301","DOIUrl":"https://doi.org/10.1111/jog.16301","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>High-risk HPV infection is a necessary but not sufficient factor for the development of precancerous lesions and cervical cancer. Beyond mere HPV positivity, the persistence of infection over time plays a crucial role. This study aims to evaluate the clearance and persistence rates of HPV 16 and 18 genotypes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The cervical cytology results were reported using the 2014 Bethesda System classification. The cervical cytology samples were analyzed using the Roche Cobas® 4800 HPV tests. Patients with any HPV genotype other than 16 or 18, those with missing data, those who were lost to follow-up, those who underwent excisional procedures or hysterectomy, and those with high-grade cervical dysplasia were excluded from this study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 191 patients (mean age: 41.2 ± 0.6 years, 16.8% postmenopausal), the mean follow-up was 21.6 ± 0.7 months. No significant differences were found between the clearance and persistence groups in age, follow-up duration, cervical biopsy, or endocervical curettage results. However, HPV 16 had a higher persistence rate (28.2%), and abnormal cytology was more frequent in the persistence group (<i>p</i> = 0.038).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Around 25% of patients had persistent HPV infection. Close monitoring is essential for those with CIN 1 on initial colposcopy, as they may have a higher risk of progressing to high-grade dysplasia compared to those without dysplasia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}