Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Histone Deacetylase 10 Inhibitors Suppress Progression of Endometriosis via Activation of Interferon Regulatory Factor 6 and Dachshund Homolog 1.","authors":"Saki Aso, Shusaku Kurogi, Shuichi Kubo, Naoki Hijiya, Yoko Aoyagi, Kentaro Kai, Eiji Kobayashi, Kaei Nasu","doi":"10.1111/jog.70315","DOIUrl":"https://doi.org/10.1111/jog.70315","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the mechanisms of histone deacetylase (HDAC) 10 inhibitors (HDAC10Is) action in endometriosis and the target molecules of HDAC10Is.</p><p><strong>Methods: </strong>We assessed the effects of HDAC10Is, tucidinostat and TH34, on the proliferation and the cell cycle in human endometriotic cyst stromal cells (ECSCs). Target genes of HDAC10 were identified by RNA sequencing. We assessed the expression of dachshund homolog 1 (DACH1) and interferon regulatory factor 6 (IRF6) mRNA in ECSCs and normal endometrial stromal cells. The functions of DACH1 and IRF6 were confirmed by compulsory expression of these genes in ECSCs using lentivirus. Effects of tucidinostat and TH34 on the promoter acetylation of the DACH1 and IRF6 genes in ECSCs were assessed by chromatin immunoprecipitation assays.</p><p><strong>Results: </strong>Both HDAC10Is had an inhibitory effect on the proliferation of ECSCs and caused them to enter cell cycle arrest at G0/G1. DACH1 and IRF6 were identified as the target genes of HDAC10. HDAC10Is caused acetylated histones to accumulate in the promoters of the genes encoding DACH1 and IRF6 in ECSCs.</p><p><strong>Conclusions: </strong>These findings indicate that HDAC10 is a factor which contributes to endometriosis pathogenesis by inhibiting DACH1 and IRF6 expression, and that HDAC10Is are therefore promising agents for endometriosis treatment.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 5","pages":"e70315"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uterine and Sigmoid Colon Perforation Following Hysteroscopy-Guided Microwave Endometrial Ablation (MEA) in a Patient With a Bicornuate Uterus and Multiple Myomas: A Case Report.","authors":"Kanae Dofutsu, Kumi Masuda, Masami Takemura, Tomoko Sumikura, Ken-Ichiro Morishige, Masahiko Takemura","doi":"10.1111/jog.70293","DOIUrl":"https://doi.org/10.1111/jog.70293","url":null,"abstract":"<p><p>In Japan, the microwave endometrial ablation system (MEA, Microsulis PLC, Waterlooville, UK) is the most widely used device for endometrial ablation and is considered a minimally invasive, uterus-preserving treatment for menorrhagia. Although MEA is generally safe, uterine and/or bowel perforation can occur as a rare but serious complication. We report a case of uterine and sigmoid colon perforations following hysteroscopy-guided MEA in a patient with a bicornuate uterus, endometriosis, and multiple uterine myomas. To our knowledge, this is the first reported case of simultaneous uterine and bowel perforation due to thermal injury after MEA in a patient with a bicornuate uterus. Careful preoperative evaluation and appropriate postoperative counseling are crucial, particularly in patients with uterine anomalies or suspected intra-abdominal adhesions.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 5","pages":"e70293"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Pamiparib Monotherapy in Recurrent Ovarian Cancer After Prior PARPi Exposure: A Prospective, Open-Label, Single-Arm, Phase II Study.","authors":"Feng Cheng, Lu Sun, Feng Shao, Li Yang, Guangyi Jiang, Jianqing Zhu","doi":"10.1111/jog.70292","DOIUrl":"https://doi.org/10.1111/jog.70292","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the efficacy and safety of pamiparib monotherapy in recurrent ovarian cancer (rOC) after prior PARPi exposure.</p><p><strong>Methods: </strong>This was a prospective clinical trial. Fifteen patients were enrolled between August 2022 and December 2023. Oral pamiparib 60 mg twice daily was administered until conditions specified in the protocol. Primary endpoint was clinical benefit rate ≥ 4 months (CBR4m; percentage of patients who sustained complete response, partial response [PR], and stable disease for at least 4 months). Secondary endpoints included progression-free survival (PFS), overall response rate (ORR), overall survival (OS), and safety.</p><p><strong>Results: </strong>Median number of previous treatment line was 3 (range, 2-6). CBR4m was 26.7% and the study was halted in the first stage according to the pre-set statistical criteria. Two patients achieved PR for an ORR of 13.3%. With a median follow-up of 16.1 months, median PFS and OS were respectively 2.8 (95% confidence interval [CI], 1.6-NR) and 15.6 (95% CI, 8.4-NR) months. Subgroup analyses showed CBR4m of 37.5% (3/8) in BRCAmut and 14.3% (1/7) in BRCAwt cohorts. CA-125 response according to GCIG criteria was observed in 26.7% of patients. There were no treatment-related serious adverse events or deaths.</p><p><strong>Conclusions: </strong>Pamiparib monotherapy preliminarily showed limited efficacy and acceptable safety profiles in heavily pretreated rOC after prior PARPi exposure. The results suggested that single-agent pamiparib retreatment may not be an effective treatment for this patient population; further investigation of combining PARPi with agents with different mechanisms may be warranted.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 5","pages":"e70292"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Predictive Model for Intrapartum Cesarean Delivery in Multiparous Women After Active Labor Onset.","authors":"Yanqing Liu, Jinyin Fan, Feng Man, Han Hu, Bo Tang","doi":"10.1111/jog.70294","DOIUrl":"https://doi.org/10.1111/jog.70294","url":null,"abstract":"<p><strong>Objective: </strong>Although prediction models for cesarean delivery have been established for nulliparous women, few have been developed for multiparous women, particularly for predicting intrapartum cesarean delivery after the onset of active labor. This study aimed to develop and validate a risk prediction model for intrapartum cesarean delivery in this population and evaluate its clinical utility.</p><p><strong>Methods: </strong>We conducted a retrospective case-control study at a single tertiary center (Suining Central Hospital, China) from January 2019 to June 2025. The study included 58 multiparous women who required cesarean delivery after active labor onset (cases) and 116 who had successful vaginal deliveries (controls). Candidate predictors included maternal age, prenatal body mass index, gravidity, parity, interdelivery interval, induction of labor, amniotic fluid characteristics, and fetal abdominal circumference. Predictors were identified through univariate analyses (Mann-Whitney U test for continuous variables, chi-square tests for categorical variables) followed by multivariate logistic regression. Model performance was evaluated by assessing discrimination (area under the receiver operating characteristic curve [AUC]), calibration (Hosmer-Lemeshow goodness-of-fit test), and internal validity (bootstrapping with 1000 replicates). A clinical nomogram was developed using R software (version 4.2.3) to facilitate practical application of the prediction model.</p><p><strong>Results: </strong>The final model incorporated five independent predictors: prenatal BMI, induction of labor, interdelivery interval, fetal abdominal circumference, and amniotic fluid characteristics. The model demonstrated good discrimination, with an AUC of 0.82 (95% CI: 0.76-0.89). The Hosmer-Lemeshow test showed good calibration (p = 0.91), and bootstrap validation yielded a calibration slope of 0.92, indicating minimal overfitting.</p><p><strong>Conclusions: </strong>This novel prediction model, using readily available intrapartum variables, shows promise for identifying multiparous women at high risk of intrapartum cesarean delivery after active labor onset, potentially aiding clinical decision-making. External validation is warranted before clinical implementation.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 5","pages":"e70294"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13120863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate Change and Pregnant Women: Context of Education?","authors":"Shigeki Matsubara","doi":"10.1111/jog.70311","DOIUrl":"https://doi.org/10.1111/jog.70311","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 5","pages":"e70311"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional Reaction at Pregnancy Recognition and Risk of Postpartum Depressive Symptoms.","authors":"Takuma Yamada, Rena Suzuki, Mamiko Kaneko, Taeko Oota, Takeshi Murakoshi","doi":"10.1111/jog.70297","DOIUrl":"https://doi.org/10.1111/jog.70297","url":null,"abstract":"<p><strong>Aim: </strong>To examine whether women's emotional reaction when they first recognize their pregnancy is associated with postpartum depressive symptoms and whether risk increases across positive, ambivalent, and negative feelings.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study at a tertiary perinatal center in Japan. At the first prenatal visit, women answered the free-text question, \"How did you feel when you found out you were pregnant?\" Responses were coded as positive, ambivalent, or negative; unclear descriptions were excluded. All women who delivered at ≥ 22 weeks' gestation between 2018 and 2024 were eligible. Postpartum depressive symptoms at 1 month were assessed using the Edinburgh Postnatal Depression Scale. Multivariable logistic regression with multiple imputation for missing EPDS and covariates estimated adjusted odds ratios (aORs) and 95% confidence intervals (CIs), adjusting for age, parity, single status, employment, prior mental illness, infertility treatment, plurality, and prior miscarriage. Complete-case analyses were performed as sensitivity analyses.</p><p><strong>Results: </strong>Of the 8932 women, 6835 (76.5%) reported positive, 1729 (19.4%) ambivalent, and 368 (4.1%) negative feelings. The PPD prevalence was 3.5%, 6.2%, and 9.0%, respectively. Compared with positive feelings, aORs were 1.69 (95% CI, 1.30-2.19) for ambivalent and 2.56 (95% CI, 1.73-3.79) for negative feelings (P for trend < 0.001). Estimates were similar in complete-case analyses.</p><p><strong>Conclusions: </strong>Free-text emotional reactions at pregnancy recognition, categorized as positive, ambivalent, or negative, were strongly and progressively associated with postpartum depressive symptoms. Simple assessment of women's feelings when they discover pregnancy may help identify those at increased risk early in the perinatal course.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 5","pages":"e70297"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placenta Accreta Spectrum: A Call for Renewed Caution.","authors":"Shigeki Matsubara","doi":"10.1111/jog.70301","DOIUrl":"https://doi.org/10.1111/jog.70301","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 5","pages":"e70301"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hysteroscopy Is A Promising Diagnostic and Therapeutic Approach for Vaginal Foreign Bodies in Preadolescent Girls.","authors":"Xiaolin Wang, Tianjiao Liu, Xiaoqi Jiang, Liwen Yang, Dehua Wan, Bao Qiao","doi":"10.1111/jog.70296","DOIUrl":"https://doi.org/10.1111/jog.70296","url":null,"abstract":"<p><strong>Background: </strong>Vaginal foreign bodies (VFBs) are rare yet clinically significant in preadolescent gynecology. Prompt identification and removal are crucial to avert complications such as infection, mucosal injury or ulceration, and potential long-term reproductive consequences. Although hysteroscopic vaginoscopy is widely regarded as the reference standard and allows simultaneous extraction, ultrasound is more commonly used because it is noninvasive, inexpensive, and readily accessible. In China, however, hysteroscopy for VFBs is underutilized due to cultural and socioeconomic considerations and concerns related to anesthesia.</p><p><strong>Methods: </strong>We conducted a retrospective review of 73 girls with suspected or hysteroscopically confirmed VFBs managed at Chengdu Women's and Children's Central Hospital or Yunyang County People's Hospital between January 2011 and February 2025. Extracted variables included age, presenting symptoms and duration, foreign-body type, pathology results, and length of stay. Diagnostic performance of transabdominal and transperineal ultrasound was evaluated with hysteroscopy as the comparator.</p><p><strong>Results: </strong>Vaginal discharge and bleeding were the leading clinical presentations (34/73, 46.6%; 27/73, 37.0%, respectively). Commonly retrieved objects included textile fibers (20/73, 27.4%) and plastic tubes or fragments (5/73, 6.8%). Transabdominal ultrasound showed sensitivity, specificity, and overall accuracy of 0.556, 0.412, and 0.521, respectively. Transperineal ultrasound yielded higher sensitivity (0.704) and accuracy (0.606) but remained limited in specificity (0.294).</p><p><strong>Conclusion: </strong>Ultrasound demonstrated suboptimal diagnostic performance for VFBs in preadolescent girls. Given its greater diagnostic yield and therapeutic utility, hysteroscopy should be considered earlier as a preferred diagnostic and treatment option, especially in cases with negative ultrasound findings of foreign body but persistent clinical symptoms.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 5","pages":"e70296"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between the Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) Score and Lymph Node Metastasis in Early and Locally Advanced Cervical Cancer.","authors":"Oğuz Kaan Köksal, Şahin Kaan Baydemir, Hande Nur Öncü, Fatma Ecem Bakan, Neslihan Öztürk, Gökçen Ege, Candost Hanedan, Vakkas Korkmaz","doi":"10.1111/jog.70290","DOIUrl":"https://doi.org/10.1111/jog.70290","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between hemoglobin-albumin-lymphocyte-platelet (HALP) score and lymph node metastasis (LNM) in patients with early and locally advanced cervical cancer.</p><p><strong>Methods: </strong>This retrospective observational cohort study included patients with FIGO 2018 stage IA-IIIC cervical cancer treated at a tertiary gynecologic oncology center between November 2022 and January 2025. Lymph node status was determined by pathological and/or radiological evaluation. HALP score was calculated using pretreatment hemoglobin, albumin, lymphocyte, and platelet values. Receiver operating characteristic (ROC) analysis was performed to determine the optimal HALP cutoff value to predict LNM. Univariate and multivariate logistic regression analyses were conducted to identify factors associated with LNM, adjusting for established clinicopathological variables.</p><p><strong>Results: </strong>A total of 136 patients were included. Patients with LNM had significantly lower HALP scores than those without LNM (median 29.8 vs. 42.8, p = 0.001). ROC analysis demonstrated a moderate discriminative ability of HALP for predicting LNM (AUC 0.697, 95% CI 0.610-0.785), with an optimal cutoff value of 22.4. Sensitivity analysis in surgically staged patients (n = 83) yielded consistent results (AUC 0.692; p = 0.006). In univariate analysis, HALP ≤ 22.4, tumor size > 2 cm, lymphovascular space invasion (LVSI), and parametrial involvement were significantly associated with LNM. In multivariate analysis, HALP ≤ 22.4 and LVSI remained independent predictors of LNM.</p><p><strong>Conclusion: </strong>The HALP score is a simple, inexpensive, and readily available immunonutrition index that may serve as an adjunctive biomarker for pretreatment risk stratification of LNM in patients with early and locally advanced cervical cancer. Prospective multicenter studies are warranted to confirm these findings.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 5","pages":"e70290"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Energy Distribution Between Dinner and Breakfast With Depressive Symptoms in Early Pregnancy.","authors":"Yixin Jiang, Jing Luo, Lu Zheng, Kun Dai, Liping Yu, Huan Zhang, Suqing Wang","doi":"10.1111/jog.70298","DOIUrl":"https://doi.org/10.1111/jog.70298","url":null,"abstract":"<p><strong>Aim: </strong>To examine the association between the distribution of energy and macronutrients between dinner and breakfast and depressive symptoms in early pregnancy.</p><p><strong>Methods: </strong>This study used baseline data from a maternity cohort conducted in Wuhan, China. Dietary intake was assessed via a 24-h recall, and depressive symptoms were defined as EPDS ≥ 10. The differences in energy and macronutrient intake between dinner and breakfast (Δ = dinner-breakfast) were categorized into tertiles. Logistic regression models were developed to assess the associations between Δ and depressive symptoms. Isocaloric substitution models were used to evaluate the effect of shifting energy or macronutrients from dinner to breakfast.</p><p><strong>Results: </strong>Two hundred two individuals (41.74%) met the criteria for depressive symptoms. The highest tertile was associated with a significantly increased risk of depressive symptoms compared with the lowest tertile after multivariable adjustment (ΔEnergy: OR = 1.97, 95% CI: 1.21-3.19; ΔCarbohydrate: OR = 1.89, 95% CI: 1.17-3.06; ΔFat: OR = 1.65, 95% CI: 1.03-2.64). Isocalorically replacing 5% of total energy at dinner with breakfast was associated with a 7% (OR = 0.93, 95% CI: 0.86-0.99) lower risk of depressive symptoms, while macronutrient substitution between meals showed no significant effect.</p><p><strong>Conclusions: </strong>Higher energy and macronutrient intake at dinner relative to breakfast was associated with a higher risk of depressive symptoms, highlighting the potential importance of daily energy distribution for mental health in early pregnancy.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 5","pages":"e70298"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}