Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Association of intrahepatic cholestasis of pregnancy with preterm birth and low birth weight in offspring: A prospective cohort and Mendelian randomization study","authors":"Jiapeng Tang,&nbsp;Mengting Sun,&nbsp;Manjun Luo,&nbsp;Ye Chen,&nbsp;Yige Chen,&nbsp;Jianhui Wei,&nbsp;Xiaorui Ruan,&nbsp;Tingting Wang,&nbsp;Jiabi Qin","doi":"10.1111/jog.16348","DOIUrl":"https://doi.org/10.1111/jog.16348","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Intrahepatic cholestasis of pregnancy (ICP) is a common complication of pregnancy, which may lead to an increased risk of adverse pregnancy outcomes. This study aimed to use two different methods to explore the association of ICP with preterm birth (PTB) and low birth weight (LBW) in offspring.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>First, a large early pregnancy cohort with a sample size of 34 104 was used to explore the association of ICP with PTB and LBW by using logistic regression analysis. Second, using a two-sample Mendelian randomization, we further assessed the effect of ICP on PTB and birth weight based on 15 single nucleotide polymorphisms from a genome-wide association study of ICP (<i>n</i> = 210 870).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results of the cohort study show that maternal ICP was associated with an increased risk of both PTB (aOR = 1.760, 95% CI: 1.443, 2.146, <i>p</i> &lt; 0.001) and LBW (aOR = 2.220, 95% CI: 1.797, 2.741, <i>p</i> &lt; 0.001) after adjusting for potential confounders. Mendelian randomization analyses suggested a potential causal effect of ICP on the risk of PTB (OR = 1.037, 95% CI: 1.011, 1.063, <i>p</i> = 0.005) and that ICP significantly reduced birth weight (beta = −0.010, 95% CI: −0.016, −0.004, <i>p</i> = 0.002).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings suggest that ICP increases the risk of PTB and LBW, providing further evidence of these associations and highlighting the need for increased clinical monitoring of pregnant women with ICP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can vaginal natural orifice transluminal endoscopic surgery hysterectomy be performed in patients with an enlarged uterus?","authors":"Kemal Güngördük,&nbsp;Varol Gülseren,&nbsp;Berican Şahin Uyar,&nbsp;Özgün Akbaş,&nbsp;Serkan Üstüntaş,&nbsp;Emre Biton,&nbsp;İsa Aykut Özdemir","doi":"10.1111/jog.16345","DOIUrl":"https://doi.org/10.1111/jog.16345","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>In this study, the application of vaginal natural orifice transluminal endoscopic surgery (vNOTES) and conventional laparoscopy (CLS) underwent hysterectomy in patients with enlarged uterus was compared.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This multicenter study enrolled patients with an enlarged uterus (≥300 g) who underwent minimally invasive hysterectomy using either CLS or vNOTES in the Department of Obstetrics and Gynecology between January 2020 and December 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the enrolled patients with an enlarged uterus, 39 (65.0%) underwent conventional laparoscopy, and 21 (35.0%) underwent vNOTES. The median operative times were 80 (50–140) min in the conventional laparoscopy group and 70 (60–130) min in the vNOTES group (<i>p</i> = 0.008). Median blood loss was significantly lower in the vNOTES group (140 [80–210] vs. 160 [90–370] mL; <i>p</i> = 0.013). The length of hospital stay was comparable between groups. Intraoperative bladder injury occurred in one patient in each group—conventional laparoscopy (2.6%) and vNOTES (4.8%) (<i>p</i> = 0.651). Conversion to laparotomy was required in three patients (7.7%) in the CLS group and one patient (4.8%) in the vNOTES group (<i>p</i> = 0.664). The visual analog scale pain score was significantly lower in the vNOTES group at 6, 12, and 24 h postoperatively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>vNOTES was confirmed to be a safe, feasible, and effective approach for hysterectomy in patients with an enlarged uterus.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophils and other blood cell traits in the risk of infertility population: A Mendelian randomization analysis","authors":"Shiqi Yi,&nbsp;Ying Feng,&nbsp;Yuping Zhang,&nbsp;Linyu Zhang,&nbsp;Xinrui Sun,&nbsp;Yi Zhang,&nbsp;Qianhong Ma,&nbsp;Fang Ma","doi":"10.1111/jog.16347","DOIUrl":"https://doi.org/10.1111/jog.16347","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Abnormalities in blood cell parameters, including eosinophil traits, have been implicated in reproductive system damage. However, their specific relationship with infertility and abnormal spermatozoa remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>In this study, we investigated 23 blood cell parameters, including eosinophil traits, using bidirectional Mendelian randomization analysis to explore their causal relationship with male and female infertility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We utilized data from the INTERVAL study, UK Biobank, Blood Cell Consortium, and GWAS Catalog for 23 blood cell parameters, as well as GWAS data from the FinnGen database for two infertile populations and one clinical phenotype related to infertility. MR analysis was conducted employing various methods, including inverse-variance weighting (IVW), to obtain statistically significant results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the blood cell parameters examined, three were associated with the risk of male infertility: eosinophil percentage of granulocytes, eosinophil cell count, and mean sphered cell volume. Among these, eosinophil levels exhibited the most significant correlation with male infertility. In contrast, no blood cell traits were identified as risk factors for female infertility. However, basophil cell count and hemoglobin concentration-related traits appeared to serve as protective factors for female infertility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Abnormal eosinophil levels may increase the risk of male infertility. However, given the limitations inherent in the observational design of this MR study, further research is required to assess the potential therapeutic effects of eosinophil reduction in idiopathic male infertility. Regarding female infertility, the study suggests that certain blood cell traits, such as basophil cell count, may act as protective factors, which warrants further investigation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent cisplatin chemotherapy with intensity-modulated radiotherapy followed by consolidation chemotherapy in early-stage cervical cancer patients with high-risk factors after radical hysterectomy","authors":"Si-Tong Wang,&nbsp;Gui-Fen Ma,&nbsp;Chun-Li Xiao,&nbsp;Ting-Yan Shi,&nbsp;Li-Bing Xiang,&nbsp;Li Ma,&nbsp;Gen-Lai Lin","doi":"10.1111/jog.16346","DOIUrl":"https://doi.org/10.1111/jog.16346","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the efficacy and toxicity of consolidation chemotherapy (C-CT) following concurrent cisplatin chemotherapy combined with intensity-modulated radiotherapy (IMRT) in patients with early-stage cervical cancer who present high-risk factors (HRFs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Between 2013 and 2023, a total of 190 women were included in this retrospective study. Among these, 82 patients received postoperative concurrent chemoradiotherapy (CCRT) with weekly cisplatin and IMRT (45.0–50.4 Gy), followed by C-CT, while 108 patients received CCRT alone. A propensity score matching (PSM) was performed with a ratio of 1:1. Clinical parameters, overall survival (OS), and relapse-free survival (RFS) were analyzed for both groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median follow-up duration was 50.2 months. The 4-year OS rates were 88.7% in the C-CT group and 87.9% in the CCRT-only group (<i>p</i> = 0.886). The 4-year RFS rates were 76.3% for the C-CT group and 80.5% for the CCRT-only group (<i>p</i> = 0.289). In patients with three or more positive lymph nodes, C-CT was associated with significantly improved OS compared to the CCRT-only group (HR 0.14, 95% CI 0.02–0.88, <i>p</i> = 0.036), while RFS showed no significant difference (HR 0.80, 95% CI 0.27–2.32, <i>p</i> = 0.676). However, the incidence of grade 3/4 hematologic toxicity was higher in the C-CT group (16.8% vs. 1.7%, <i>p</i> = 0.009).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study found that C-CT following concurrent cisplatin chemotherapy with IMRT did not confer additional benefits over CCRT alone in the majority of early-stage cervical cancer patients with HRFs, except in those with three or more positive lymph nodes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive score using umbilical vein leucine-rich α-2 glycoprotein as a useful biomarker for diagnosing histological chorioamnionitis in preterm infants","authors":"Genichiro Sotodate,&nbsp;Satoshi Serada,&nbsp;Mitsumasa Osakabe,&nbsp;Fumiaki Takahashi,&nbsp;Atsushi Matsumoto,&nbsp;Yukiko Toya,&nbsp;Shigekuni Tsuchiya,&nbsp;Minoru Fujimoto,&nbsp;Tetsuji Naka,&nbsp;Manami Akasaka","doi":"10.1111/jog.16344","DOIUrl":"https://doi.org/10.1111/jog.16344","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>We investigated the value of leucine-rich α-2 glycoprotein (LRG) in cord blood for diagnosing histological chorioamnionitis (HCAM) in preterm infants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective cohort study included 68 infants, born between 22 and 31 weeks of gestation, comprising 29 infants without and 39 infants with HCAM. Maternal, infant, and cord blood inflammatory markers were compared between the groups, and expression levels were compared using immunohistopathological staining of placental tissue.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The umbilical vein leucine-rich α-2 glycoprotein (UV-LRG) and gestational age were independent risk factors for HCAM (odds ratio [OR] 2.395, 95% confidence interval [CI] 1.230–4.663, OR 0.678, 95% CI 0.492–0.934, respectively). The predictive score was calculated as follows: 9.575 + (−0.386) × gestational age + 0.756 × UV-LRG. The predictive score (area under the curve 0.802, 95% CI [0.696–0.958]) appeared to be a reliable diagnostic model for HCAM and outperformed other inflammatory markers. At a cut-off value of 0.852, the predictive score showed a sensitivity of 57.1% and specificity of 93.1% for diagnosing HCAM. Immunohistopathological evaluation of the placenta revealed stronger LRG expression in the trophoblasts (TBs) and stroma in the group with HCAM than in the group without UV-LRG levels correlated positively with the immunohistopathological LRG intensity in the TBs and stroma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The predictive score using UV-LRG is a more useful biomarker than the other inflammatory markers for HCAM diagnosis. Investigating the mechanism by which TBs produce LRG and by which LRG migrates from the TBs to the stroma may help elucidate HCAM pathogenesis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angle of progression as a potential risk factor for emergency cesarean section following induction of labor in Japanese nulliparous women at term","authors":"Satoshi Shinohara,&nbsp;Rei Sunami,&nbsp;Genki Yasuda,&nbsp;Mayuko Kasai","doi":"10.1111/jog.16343","DOIUrl":"https://doi.org/10.1111/jog.16343","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To examine the association between the angle of progression (AOP) measured before labor induction and the occurrence of emergency cesarean section (ECS). Additionally, a predictive model was developed for ECS following labor induction using sonographic and clinical data accessible to obstetricians.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective observational cohort study was conducted at the Yamanashi Prefectural Central Hospital between January 2022 and July 2024. A total of 143 nulliparous Japanese women with singleton term pregnancies in the cephalic presentation were recruited. Transabdominal and transperineal ultrasound examinations were performed before labor induction. All variables with a <i>p</i>-value of &lt;0.05 in the bivariate analysis were evaluated using multivariable logistic regression analysis to examine the association between AOP and ECS and to identify AOP cutoff values predictive of ECS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The incidence of ECS was 39.9% (57/143). Multivariable analysis indicated that the AOP (adjusted odds ratio [OR]: 0.89, 95% confidence interval [CI]: 0.85–0.94) and pre-pregnancy body mass index (adjusted OR: 1.14, 95% CI: 1.03–1.27) were associated with ECS. The prediction model had a sensitivity and specificity of 82.5% and 82.6%, respectively (area under the curve [AUC] = 0.88). The optimal AOP cutoff point for predicting ECS was 91.2° (AUC: 0.77).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The ECS prediction model incorporating AOP may facilitate individualized counseling before labor induction. Women with an AOP less than 91.2° are at an elevated risk for ECS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and predictors of non-alcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD) in Indian women with polycystic ovarian syndrome","authors":"Aditi Rathi,&nbsp;Deepti Goswami,&nbsp;Anju Garg,&nbsp;Smita Kaushik,&nbsp;Niharika Dhiman","doi":"10.1111/jog.16335","DOIUrl":"https://doi.org/10.1111/jog.16335","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To study the prevalence and predictors of non-alcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD) in women with polycystic ovarian syndrome (PCOS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Seventy-eight PCOS patients and 78 age and body mass index (BMI)-matched controls were studied. PCOS was diagnosed by Rotterdam criteria. Clinical examination, biochemical, and hormonal investigations, and transabdominal sonography were done for all participants. Based on gray-scale sonography, NAFLD was graded as 0, 1, 2, and 3. MAFLD was diagnosed when imaging or serological evidence of fatty liver disease was present and one of the following three criteria was met: overweight/obesity, diabetes, or metabolic disorders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Women with PCOS had a higher prevalence of NAFLD (53.8% vs. 17.9%; <i>p</i> &lt; 0.001), MAFLD (70.5% vs. 48.7%; <i>p</i> &lt; 0.01), insulin resistance (HOMA-IR 2.8 ± 1.3 vs. 1.4 ±0.3; <i>p</i> &lt; 0.001) and metabolic syndrome (51.3% vs. 10.3%; <i>p</i> &lt; 0.001) and higher values of waist-hip ratio (0.88 ± 0.1 vs. 0.83 ± 0.1; <i>p</i> &lt; 0.001), alanine transferase (44.1 ± 19.7 vs. 30.3 ± 7.6; <i>p</i> &lt; 0.001), and free androgen index (FAI; 7.8 ± 4.4 vs. 3.4 ± 1.7; <i>p</i> &lt; 0.001) than controls. Twenty-three percent of PCOS patients with NAFLD and 18.4% with MAFLD had Grades 2 and 3 disease. Among different PCOS phenotypes, phenotype A was maximally affected with NAFLD and MAFLD. Multiple regression analysis showed that PCOS status and FAI were the predicting factors for NAFLD. MAFLD was significantly associated with hepatic steatosis index (HSI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PCOS patients were at a higher risk for NAFLD and MAFLD than age- and BMI-matched controls. The prevalence of NAFLD and MAFLD was highest in phenotype A. Hyperandrogenism is a predictor of NAFLD in PCOS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative outcomes in patients with very low-risk endometrial cancer undergoing surgery without lymph node dissection: Results from KGOG 2021","authors":"Dae Hoon Jeong,&nbsp;Yong Beom Kim,&nbsp;Kidong Kim,&nbsp;Jong-Min Lee,&nbsp;Dae Gy Hong,&nbsp;Jaeman Bae,&nbsp;Kwang-Beom Lee,&nbsp;Chae Hyeong Lee,&nbsp;Myong Cheol Lim,&nbsp;Min Kyu Kim","doi":"10.1111/jog.16342","DOIUrl":"https://doi.org/10.1111/jog.16342","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the perioperative outcomes of patients with endometrial cancer meeting the Korean Gynecologic Oncology Group (KGOG) criteria who underwent surgery without lymph node dissection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included 153 patients who met the KGOG criteria: (1) endometrioid histology, (2) myometrial invasion &lt;50%, (3) tumor confined to the corpus, (4) no lymph node &gt;1 cm, and (5) serum CA125 ≤ 35 U/mL. The patients underwent surgery without lymph node dissection at 11 hospitals in Korea between February 2020 and May 2024. Perioperative outcomes were collected prospectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 153 patients, 89 (58%) underwent surgery without lymph node removal, while 64 (42%) underwent surgery with lymph node removal. Minimally invasive surgery was performed in &gt;90% of cases, with a conversion rate to laparotomy of 1%. The mean surgery time was 109.37 ± 37.67 min. Estimated blood loss was minimal (93.74 ± 93.13 mL), with a mean hemoglobin drop of 1.32 ± 1.01 g/dL. Transfusions were required in only three patients (2%). Postoperative hospital stays exceeded 2 days in 51% of cases. Lymph node metastasis was observed in just one case (1%). Adverse events included 52 grade 1 and 2 grade 2 events (e.g., headache, paresthesia). Patients undergoing lymph node removal (primarily sentinel lymph node biopsy) had significantly longer surgery times and postoperative hospital stays compared to those without lymph node removal.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Surgery without lymph node dissection demonstrated excellent perioperative outcomes and minimal adverse events in patients meeting KGOG criteria.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16342","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of the prognostic nutritional index in the first trimester on birth weight: A retrospective study","authors":"Arife Akay,&nbsp;Yıldız Akdaş-Reis,&nbsp;Khurshud Hajıyeva,&nbsp;Neval Çayonu-Kahraman,&nbsp;Yaprak Engin-Üstün","doi":"10.1111/jog.16341","DOIUrl":"https://doi.org/10.1111/jog.16341","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The study aimed to investigate the effect of the maternal prognostic nutritional index (PNI) in the first trimester on birth weight.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study was conducted on term births between 2015 and 2022. The subjects were classified into three categories based on their birth weight: small gestational age (SGA), adequate gestational age (AGA), and large gestational age (LGA). The values of PNI, albumin (ALB), and hemoglobin (HB) were determined in the first trimester. PNI, ALB, and HB levels, demographic, obstetric, and neonatal outcomes were compared in the three groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 302 singleton pregnancies were included, with 79 cases classified as SGA (26.2%), 147 cases as AGA (48.6%), and 76 cases as LGA (25.2%). The mean ages and body mass index (BMI) of the groups were found to be similar (<i>p</i> &lt; 0.05). HB (12.3 ± 1.28 g/dL), ALB (3.5 ± 0.37 g/dL), and PNI (35.7 ± 3.78) levels were found to be lower in the SGA group (<i>p</i> &lt; 0.05). The cut-off values for ALB and PNI were 3.5 g/dL and 35, respectively (80.3% and 81% sensitivity and 54.4% specificity). A positive correlation was identified between the 1 min Apgar score and both ALB and PNI (<i>p</i> = 0.002, <i>r</i> = 0.176).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>A reduction in PNI, HB, and ALB levels was observed in the SGA group, whereas no significant difference was identified in the LGA group. To achieve an adequate birth weight, it is recommended that the nutritional status and anemia of the mother be improved before and during pregnancy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of drospirenone as a progestin-only pill in Japanese women: A phase III study","authors":"Kunio Kitamura,&nbsp;Enrico Colli,&nbsp;Ryoko Kikuyama,&nbsp;Yumiko Kurihara,&nbsp;Rieko Azuma,&nbsp;Tomoya Kagawa","doi":"10.1111/jog.16340","DOIUrl":"https://doi.org/10.1111/jog.16340","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the efficacy and safety of 4 mg of drospirenone (DRSP), a progestin-only pill (POP), for contraception in Japanese women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a multicenter, open-label, single-arm study. The dosing period of DRSP was 13 cycles, each lasting for 28 days. In one cycle, 4 mg of DRSP was administered orally once daily for the first 24 days, followed by a placebo for 4 days.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Data from 276 subjects were analyzed, with a total of 3319 DRSP exposure cycles. Pregnancy occurred in one subject. The overall Pearl Index [95% CI] was 0.39 [0.01, 2.18], and the cumulative pregnancy rate [95% CI] was 0.40% [0.06, 2.81]. Of the 276 subjects, 273 (98.9%) experienced treatment-emergent adverse events (TEAEs) and 264 (95.7%) experienced adverse drug reactions. All TEAEs were mild or moderate, with no severe events. The most common TEAE was intermenstrual bleeding (irregular uterine bleeding) (89.5%). Although 31.9% of the subjects had risk factors for venous thromboembolism (VTE), no VTE-related TEAEs were observed. The incidence of unscheduled bleeding [95% CI] across all cycles was 91.6% [87.7, 94.3].</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>DRSP, the first POP in Japan, is effective and safe as a contraceptive in Japanese women. It provides a new contraceptive option for Japanese women, including those at risk of VTE for whom combined oral contraceptives are contraindicated.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16340","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}