Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Integrated analysis of DNA methylation and transcriptome profiles to identify oxidative stress-related placenta-specific molecules for preeclampsia","authors":"Yang Xu, Xiaolin Zeng, Shuang Guo, Yuan Liao, Danqing Zhao","doi":"10.1111/jog.16209","DOIUrl":"https://doi.org/10.1111/jog.16209","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Preeclampsia (PE) is a pregnancy-specific hypertensive disorder and one of the leading causes of maternal mortality. However, its etiology and pathogenesis are not yet fully clarified. This study aimed to uncover methylation-regulated oxidative stress-related placenta-specific molecules in PE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Two PE datasets, GSE57767 and GSE25906, were subjected into this study. The oxidative stress-related genes were derived from GeneCards database. Differential methylation and expression analysis were applied to identify methylation-regulated oxidative stress-related genes in PE. The methylation-regulated oxidative stress-related placenta-specific molecules were determined by receiver operating characteristic (ROC) analysis. The single-gene gene set enrichment analysis (GSEA) were executed using the R “clusterProfiler.” The transcription factor (TF)-gene regulatory network of placenta-specific molecules was created through Network Analyst database and Cytoscape software. The drug-gene network of placenta-specific molecules were developed through DGIdb database and Cytoscape software. Eventually, we further examined biomarker expression trends in the collected clinical samples using real time quantitative PCR (RT-qPCR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 13 methylation-regulated oxidative stress-related genes in PE were identified. Then, five genes (<i>VIM</i>, <i>SNCA</i>, <i>PIK3CG</i>, <i>DNM2</i>, and <i>BMP6</i>) were authenticated as methylation-regulated oxidative stress-related placenta-specific molecules in PE by ROC curves, suggesting a potential clinical diagnostic value. Single-gene GSEA pointed to the linkage of these five genes to the immune-related pathways, ferroptosis, and oxidative phosphorylation. Finally, a TF-gene regulatory network containing 32 nodes and 38 edges and a drug-gene network containing 126 nodes and 123 edges were generated based on methylation-regulated oxidative stress-related placenta-specific molecules in PE. Ultimately, the experimental results confirmed that the expression trends of <i>VIM</i>, <i>PIK3CG</i>, and <i>BMP6</i> in our collected clinical samples were in line with the expression trends in the GSE25906 dataset.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Three genes, <i>VIM</i>, <i>PIK3CG</i>, and <i>BMP6</i>, were identified as methylation-regulated oxidative stress-related placenta-specific molecules in PE. This might have helped to understand the pathogenesis of the disease and might also have pro","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 3","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16209","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143564520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Underrecognized diagnostic discordance and delay in endometrial dedifferentiated and undifferentiated carcinoma","authors":"Saria Kawano,&nbsp;Hiroshi Yoshida,&nbsp;Nao Kikkawa,&nbsp;Mayumi Kobayashi-Kato,&nbsp;Yasuhito Tanase,&nbsp;Masaya Uno,&nbsp;Mitsuya Ishikawa","doi":"10.1111/jog.16260","DOIUrl":"https://doi.org/10.1111/jog.16260","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Dedifferentiated and undifferentiated endometrial carcinoma (DC/UC) is a rare subtype of endometrial cancer characterized by undifferentiated carcinoma components. This study aimed to investigate diagnostic discrepancies and delays in DC/UC and compare them with low-grade endometrioid carcinoma (LGEC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed 20 DC/UC and 40 LGEC cases finally diagnosed at our hospital (2016–2024). We compared the data of the two groups, including clinicopathologic characteristics and diagnostic intervals defined as the time from the date of initial biopsy to the date of definitive diagnosis. We assessed diagnostic discordances between preoperative diagnoses, including radiological, clinical, and biopsy, and final diagnoses with immunohistochemical analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>DC/UC cases exhibited significantly longer diagnostic intervals (median 46 vs. 5 days, <i>p</i> = 0.037) and required more biopsy attempts (median two vs. 1, <i>p</i> = 0.002) and immunohistochemical tests (median 19 vs. 6, <i>p</i> = 0.001) than LGEC cases. In preoperative diagnoses, 60% of DC/UC cases showed diagnostic discrepancies. Radiological findings frequently suggested uterine sarcoma in DC/UC (30%, 6/20). Only 50% of DC/UC were suggested via initial biopsy. Immunohistochemistry revealed mismatch repair deficiency in 70% of DC/UC cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Frequent diagnostic discrepancies and delays were observed in DC/UC, possibly due to its atypical imaging and histopathological features. Raising awareness of DC/UC's clinical and pathological characteristics is crucial to minimizing diagnostic delays. Given its frequency (at least 1% of endometrial cancers) and eligibility for emerging therapies, prioritizing DC/UC in differential diagnoses and improving diagnostic workflows through interdisciplinary collaboration are required for timely and effective treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 3","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143564519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of attitudes toward sexuality and sexual function on marital satisfaction during pregnancy","authors":"Derya Öztürk Özen,&nbsp;Neslihan Yılmaz Sezer,&nbsp;Menekşe Nazlı Aker,&nbsp;Melike Demir Çaltekin","doi":"10.1111/jog.16258","DOIUrl":"https://doi.org/10.1111/jog.16258","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Aim of the study investigating the impact of attitudes toward sexuality and sexual function on marital satisfaction during pregnancy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study, in which a descriptive design was used, was conducted with 520 pregnant women. The Introductory Information Form, The Attitude Scale toward Sexuality During Pregnancy (AStSdP) (subdimensions: anxiety about sexual intercourse during pregnancy [anxiety], dysfunctional beliefs and values about sexuality during pregnancy [beliefs and values], and approving sexuality during pregnancy [approval]), Female Sexual Function Index (FSFI) (subdimensions: sexual function, including desire, arousal, lubrication, orgasm, satisfaction, and pain), and Marital Adjustment Scale (MAS) (subdimensions: family, sex, and self) were used for data collection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean AStSdP score was 104.61 ± 18.75, the mean FSFI score was 19.54 ± 8.91, and the mean MAS score was 48.58 ± 8.54. Negative attitudes toward sexuality during pregnancy were reported by 30% of the participants, while 79.4% experienced sexual dysfunction. The AStSdP, FSFI, and MAS scores exhibited a positive correlation. Additionally, adverse economic conditions, gestational week, Anxiety, Beliefs and Values, AStSdP scores, and arousal scores were significant predictors of marital satisfaction in pregnant women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>There exists a positive relationship between attitudes toward sexuality during pregnancy, sexual function scores, and marital satisfaction. Moreover, attitudes toward sexuality during pregnancy influence marital satisfaction. Nurses and other antenatal team members should implement interventions to foster positive attitudes toward sexuality in pregnancy, as these can enhance marital satisfaction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 3","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal arrhythmias: Current evidence of prenatal diagnosis and management","authors":"Takekazu Miyoshi","doi":"10.1111/jog.16256","DOIUrl":"https://doi.org/10.1111/jog.16256","url":null,"abstract":"<p>Fetal arrhythmias present as an irregular cardiac rhythm and heart rate. Fetal echocardiography and cardiotocography play a pivotal role in diagnosing and managing fetal arrhythmia. Fetal magnetocardiography and electrocardiography can provide electrical assessment but have several limitations; thus, prenatal diagnosis of fetal arrhythmia remains challenging. Most cases of fetal arrhythmia have a structurally normal heart with isolated premature contractions that spontaneously resolve in utero or after birth without treatment. Despite the theoretical advantage of fetoplacental circulation, progression to heart failure or hydrops is found in fetuses with tachy- or bradyarrhythmia due to the limited heart rate reserve. There is a clear clinical consensus on the efficacy of transplacental antiarrhythmic therapy using digoxin, sotalol, and flecainide for fetal supraventricular tachyarrhythmia. A recent Japanese multicenter clinical trial confirmed the efficacy and safety of these agents. Fetal ventricular tachycardia is an infrequent occurrence but can be associated with heart failure, hydrops, and sudden death. It is important to search for long QT syndrome. Transplacental administration of magnesium, propranolol, mexiletine, and lidocaine, alone or in combination, has been attempted for fetal ventricular tachycardia. Fetal complete atrioventricular block is caused by maternal autoantibodies or fetal congenital heart defects and is irreversible. There is currently no consensus on the indications for fetal treatment, including beta-sympathomimetics for bradyarrhythmia. Dexamethasone and intravenous immunoglobulin have been used to prevent or treat atrioventricular block and myocarditis, but recent studies have not shown the efficacy of these agents.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 3","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epithelioid trophoblastic tumor diagnosed during a thorough examination of recurrent implantation failure: A case report","authors":"Yasuhiko Kamada,&nbsp;Junko Haraga,&nbsp;Naoyuki Ida,&nbsp;Shoji Nagao,&nbsp;Hiroyuki Yanai,&nbsp;Hisashi Masuyama","doi":"10.1111/jog.16259","DOIUrl":"https://doi.org/10.1111/jog.16259","url":null,"abstract":"<p>We describe an exceptionally rare case of epithelioid trophoblastic tumor (ETT) in a patient with recurrent implantation failure (RIF). A 38-year-old Japanese woman, gravida 1, para 1, was diagnosed with RIF following three unsuccessful cryopreserved morphologically good embryo transfers with hormone replacement cycles after thawing. She underwent hysteroscopy and endometrial biopsy to exclude chronic endometritis but was referred because ETT was strongly suspected. Following a preoperative diagnosis of stage I ETT, she underwent laparoscopic total hysterectomy and bilateral salpingo-oophorectomy. A yellowish elevated lesion was observed in the lower uterine body. Immunohistochemical staining was negative for human chorionic gonadotropin and human placental lactogen and positive for p63, with a Ki-67 proliferation index of &gt;10%. She was diagnosed with stage I ETT, but postoperative chemotherapy was not administered because of the lesion location and occurrence within 48 months of the prior term delivery. She had no recurrence at 24 months postoperatively.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 3","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The current status of preconception counseling for female cancer survivors on cardiovascular complications in pregnancy: A questionnaire survey to doctors and survivors","authors":"Nanayo Sasagasako,&nbsp;Chizuko Aoki-Kamiya,&nbsp;Yuma Tada,&nbsp;Tatsuya Miyake,&nbsp;Tadashi Maezawa,&nbsp;Hidetaka Kawabata,&nbsp;Kaoru Kawasaki,&nbsp;Masashi Takamura,&nbsp;Asuka Okunomiya,&nbsp;Jun Yoshimatsu","doi":"10.1111/jog.16252","DOIUrl":"https://doi.org/10.1111/jog.16252","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The number of childhood or adolescent and young adult cancer survivors is increasing. Often, they encounter new problems, such as late complications after cancer treatment and pregnancy. Female cancer survivors were reported to have increased risks of obstetrical complications and pregnancy-associated cardiovascular disease (CVD), such as cardiomyopathy. Therefore, preconception counseling (PC) is important. This study aimed to assess the current status of PC for cancer survivors through a questionnaire survey.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An online questionnaire survey was conducted on doctors specializing in oncology and female cancer survivors aged 18–39 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 34 doctors and 18 cancer survivors responded. Specifically, 32 (94.1%) explained the effect of cancer treatment on reproductivity, 8 (23.5%) explained the risks of CVD and other-organ complications during pregnancy, and 14 (41.2%) recommended PC and screening health checks to their patients before pregnancy. Although many doctors feel the importance and need for PC, only half responded that their facilities have a department in charge of PC. Sixteen cancer survivors (88.9%) were informed about their reproductivity before or during cancer treatment. Only two women (11.1%) were informed of the increased risks of CVD and other-organ complications during pregnancy. Four women (22.2%) received PC preoperatively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Female cancer survivors are mostly informed about their reproductive health, but poorly informed about the CVD risks after conception. Currently, the implementation rate of PC is low; thus, spreading awareness of the importance of PC among doctors and patients is necessary.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 3","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical translation of metabolomics markers in endometrial carcinoma","authors":"Nur Fatin Nabilah Mohd Sahardi,&nbsp;Manishaa Priya,&nbsp;Suzana Makpol,&nbsp;Mohamad Nasir Shafiee","doi":"10.1111/jog.16246","DOIUrl":"https://doi.org/10.1111/jog.16246","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This comprehensive review highlights the current research on metabolomics and the metabolic pathways involved in endometrial cancer (EC), offering potential non-invasive biomarkers for EC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The data was extracted from published manuscripts between 2015 and 2024 using the reputed search engine “Pubmed.” All gathered data were organized into a single table, facilitating a comparison with earlier findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results of this study revealed most metabolites identified in previous metabolomic research on EC are associated with lipid, glucose, and amino acid metabolism.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Therefore, understanding these metabolic pathway alterations in EC is crucial for improving diagnosis, prognosis, and treatments by specially targeting these metabolic pathways.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 3","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary chondrosarcoma of the ovary","authors":"Yukiko Matsuzawa,&nbsp;Hiroki Kurosawa,&nbsp;Kazuhiro Murakami,&nbsp;Mitsumasa Osakabe,&nbsp;Yoh Watanabe","doi":"10.1111/jog.16250","DOIUrl":"https://doi.org/10.1111/jog.16250","url":null,"abstract":"<p>Ovarian heterologous sarcoma is a rare malignancy. Only three cases of ovarian chondrosarcoma have been reported in the literature, and almost all of these were components of ovarian teratomas. Herein, we report the clinicopathological characteristics of an ovarian chondrosarcoma in a 68-year-old woman who had previously undergone total hysterectomy. She had no subjective symptoms, and the tumor was unexpectedly found by further examination of osteoarthritis of the hip joint. Preoperative magnetic resonance imaging revealed curious findings of a lobulated high-intensity component with a leaf-vein-like low-intensity component. Computed tomography revealed irregularly distributed ossification extending to the entire tumor. Preoperative levels of CA125, CA19-9, carcinoembryonic antigen, α-fetoprotein, and lactic dehydrogenase were all within normal limits. Macroscopic findings of the surgically resected tumor and pathologic findings revealed no teratoma component in the tumor. Finally, we diagnosed the tumor as a primary chondrosarcoma of the ovary.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematometra within a cesarean scar defect in a perimenopausal woman: A case report","authors":"Atsushi Murakami,&nbsp;Shunichiro Tsuji,&nbsp;Yu Koikawa,&nbsp;Mari Nakata,&nbsp;Suzuko Moritani,&nbsp;Takashi Murakami","doi":"10.1111/jog.16253","DOIUrl":"https://doi.org/10.1111/jog.16253","url":null,"abstract":"<p>Cesarean scar defect (CSD) is a long-term complication of cesarean section (CS). However, its risks for perimenopausal women remain unclear. We present a rare case of CSD involving hematometra in a perimenopausal woman, which led to emergency hysterectomy. A 51-year-old woman with a history of CS presented with acute abdominal pain. Transvaginal ultrasonography and magnetic resonance imaging identified a hematometra within a large CSD extending into the cervical myometrium. Emergent hysterectomy was performed due to persistent pain. Histopathology revealed a fresh hematoma within the CSD, with ectopic endometrial glands and hemorrhage on its walls. This case highlights the pathogenesis of hematometra within a CSD and underscores its potential to cause acute abdomen in perimenopausal women.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16253","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of anti-angiogenic drugs in gastric-type endocervical adenocarcinoma: A retrospective study","authors":"Jing Li,&nbsp;Dian Wang,&nbsp;Qing Duan,&nbsp;Ning Su,&nbsp;Xiufang Li,&nbsp;Haifeng Qiu","doi":"10.1111/jog.16247","DOIUrl":"https://doi.org/10.1111/jog.16247","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Gastric-type endocervical adenocarcinoma (GEA) is a rare malignant tumor that is not associated with high-risk HPV infection, known for its high invasiveness and resistance to current treatments. This study assessed the effectiveness of anti-angiogenic regimens in real-world GEA patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with GEA were enrolled between February 2012 and March 2023, and their clinicopathological characteristics were collected from their medical records. The patients were categorized into groups based on whether they received anti-angiogenic treatments or not. Survival analysis was conducted using the Kaplan–Meier method.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 43 GEA patients were enrolled in this study, with 23 cases who received anti-angiogenic drugs (nine received them as the primary treatment, 12 as first-line therapy after recurrence/metastasis, and two as second-line therapy) as the observation group. The other 20 patients who received similar treatments without the anti-angiogenic regimens serve as the control group. Compared to the control group, the addition of anti-angiogenic drugs as the primary treatment mildly extended progression-free survival (PFS) while not being statistically significant (16 months vs 11 months, <i>p</i> = 0.744). The negative results were also observed in 12 patients who started anti-angiogenic therapy as first-line therapy after recurrence/metastasis (8.5 months vs 9 months, <i>p</i> = 0.518). As for the overall survival (OS), no benefits were detected in either patients who started the anti-angiogenic therapy as primary or subsequent treatments (<i>p</i> = 0.499 and 0.450, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We firstly evaluated the efficacy of anti-angiogenic drugs in treating patients with GEA. Although with a small sample size, our preliminary results clearly proposed that the anti-angiogenic therapy failed in suppressing tumors and should not be a preferred choice for GEA. As a much rarer tumor without standard treatments, we herein warned of a pitfall for gynecologic oncologists when facing this malignancy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}