Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Pregnant Women With Ulcerative Colitis Have a Higher Risk of Delivering Small-For-Gestational-Age Infants: The Japan Environment and Children's Study (JECS)","authors":"Tamami Tsuzuki,&nbsp;Marina Minami,&nbsp;Ryuhei Nagai,&nbsp;Yusuke Oki,&nbsp;Hedeyuki Miyachi,&nbsp;Masamitsu Eitoku,&nbsp;Narufumi Suganuma,&nbsp;Nagamasa Maeda,&nbsp;The Japan Environment and Children's Study Group","doi":"10.1111/jog.70109","DOIUrl":"https://doi.org/10.1111/jog.70109","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Ulcerative colitis primarily affects individuals of reproductive age, raising concerns regarding its impact on pregnancy, lactation, and postpartum outcomes. Although numerous international studies exist, research on the Japanese population remains limited. This study aimed to analyze data from a large-scale nationwide cohort in Japan.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were derived from a prospective birth cohort study conducted between 2011 and 2014 that recruited pregnant women in early pregnancy across Japan. Of the 97 075 pregnancies, 214 were complicated by ulcerative colitis. These were compared with 96 861 pregnancies without a history of ulcerative colitis in terms of background characteristics, perinatal outcomes, and neonatal findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Pregnant women with ulcerative colitis were older and had a lower smoking rate than those without the condition. Gestational weight gain was lower in the ulcerative colitis group than in the control group. The proportion of small-for-gestational-age infants was higher in pregnancies complicated by ulcerative colitis. This risk is further elevated in patients with anemia or inflammation during early pregnancy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>There is limited research on the impact of ulcerative colitis on pregnancy in Japan. This study found that pregnancies complicated by ulcerative colitis were associated with a higher risk of delivering small-for-gestational-age infants. Further studies with more detailed data on disease status are needed to assess disease activity and perinatal risk better.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.70109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in the Management of Decreased Fetal Movement in Fetomaternal Hemorrhage With Cerebral Palsy: A Nationwide Registry Study","authors":"Yoshimitsu Wada,&nbsp;Hironori Takahashi,&nbsp;Manabu Ogoyama,&nbsp;Kenji Horie,&nbsp;Hirotada Suzuki,&nbsp;Rie Usui,&nbsp;Seung Chik Jwa,&nbsp;Akihide Ohkuchi,&nbsp;Hiroyuki Fujiwara","doi":"10.1111/jog.70106","DOIUrl":"https://doi.org/10.1111/jog.70106","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To describe how decreased fetal movement (DFM) was managed in patients with fetomaternal hemorrhage (FMH) and to evaluate the diagnostic limitations of this condition in real-world settings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study included individuals who developed FMH with cerebral palsy from the Japanese nationwide cerebral palsy registry between 2009 and 2022. We investigated whether patients experienced DFM or were prenatally diagnosed with FMH. Furthermore, we assessed how DFM was managed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This study included 57 patients who developed FMH with cerebral palsy, and none were prenatally diagnosed with FMH. DFM was present in 43/57 (75.4%) patients. A sinusoidal pattern was observed in 29/57 (50.9%) patients, and elevated middle cerebral artery peak systolic velocity (MCA-PSV) was detected in 6/10 (60.0%) patients who underwent this test. Of the 43 patients with DFM, 42 (97.7%) sought medical care for this symptom; however, only 12 (27.9%) underwent examinations on the same day as the onset of DFM, and 9 (20.9%) were admitted on that same day. Furthermore, 6/43 (14.0%) were instructed to stay home after telephone consultation or medical examination for this symptom. In five of the 43 patients (11.6%) who experienced DFM, the initial non-stress test was reactive. However, all these patients eventually developed either a non-reactive or non-reassuring fetal status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>DFM was prevalent among pregnancies complicated by FMH; however, it was often inadequately managed, resulting in diagnostic delays. Furthermore, fetal heart rate monitoring and MCA-PSV evaluations had diagnostic limitations. To facilitate early treatment, clinicians need to promptly assess preceding DFM while recognizing the limitations of existing tests.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145272661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PSG1 in Regulating Proliferation and Migration of Human Umbilical Vein Endothelial Cells Through the TGF-β/Orai3 Signaling Pathway","authors":"Yali Yang,&nbsp;Qiaofang Yang,&nbsp;Shanyan Lai,&nbsp;Mianbo Lin,&nbsp;Lichao Yuan,&nbsp;Guilan Nie,&nbsp;Xufei Fan","doi":"10.1111/jog.70092","DOIUrl":"10.1111/jog.70092","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To study the function of pregnancy-specific glycoprotein 1 (PSG1) in regulating proliferation, migration, and vascular tone of human umbilical vein endothelial cells (HUVECs), and further explore its role in placental development and potential molecular mechanisms through co-culturing HUVECs with HTR8/svneo cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>HUVECs were treated with 2, 4, and 8 μg/mL PSG1. The Cell Counting Kit-8 assay was used to test cell proliferation, apoptosis by Annexin V/PI staining, and intracellular calcium and nitric oxide (NO) levels by fluorescence microscopy. Western blotting quantified the expression of vascular endothelial growth factor (VEGF), transforming growth factor-beta (TGF-β), endothelial nitric oxide synthase (eNOS), calcium release-activated calcium channel protein 3 (Orai3), and PSG1. To study PSG1's effect on placental development, HUVECs were co-cultured with HTR8/svneo cells. siRNA-mediated knockdown of PSG1 was performed in both cell types to evaluate its impact on endothelial function, vascular tone, and trophoblast-endothelial cell interactions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PSG1 treatment enhanced HUVEC proliferation, with high concentrations reducing apoptosis. PSG1 upregulated the expression of VEGF, TGF-β, eNOS, and Orai3, and significantly increased both intracellular calcium and NO levels. Knockdown of PSG1 reduced these effects in HUVECs, and co-culture with PSG1-deficient trophoblast cells further diminished HUVEC proliferation, enhanced apoptosis, and decreased NO release. Our study highlighted the crucial role of PSG1 in endothelial cell function and vascular tone regulation. Furthermore, PSG1 modulation influenced eNOS activity, enhancing NO release, which contributed to vascular dilation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>PSG1 promotes HUVEC proliferation, inhibits apoptosis, and regulates vascular tone through the TGF-β/Orai3 signaling pathway, primarily by modulating NO production.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Rechallenge With Pembrolizumab After a Grade 3 Infusion Reaction With a Far Slower Infusion Rate and Premedication: A Case Report","authors":"Takashi Uehara,&nbsp;Kanae Tahatsu,&nbsp;Satomi Aoyama,&nbsp;Ryutaro Yamada,&nbsp;Shinichiro Minobe","doi":"10.1111/jog.70101","DOIUrl":"10.1111/jog.70101","url":null,"abstract":"<div>\u0000 \u0000 <p>Patients who experience grade 3 and 4 infusion reactions during pembrolizumab treatment should discontinue treatment, per the prescribing guidelines. We report a case of successful rechallenge with pembrolizumab after a grade 3 infusion reaction with a slow infusion rate and premedication. A Japanese woman in her 60s with recurrent endometrial cancer was treated using a combination of pembrolizumab and lenvatinib. During the second cycle of pembrolizumab treatment, delayed and recurrent grade 3 infusion reactions associated with systematic flushes and elevated body temperature occurred. Pembrolizumab rechallenge was performed, accompanied by the administration of premedication (histamine receptor inhibitors and acetaminophen) and reduction of the infusion rate. The flow rate was reduced to 25% of the normal rate, followed by a 50% reduction of the normal infusion rate; no recurrence of the infusion reaction was noted. Proper management of severe-grade infusion reactions may allow the continuation of pembrolizumab treatment, thereby improving patient prognosis.</p>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global research trends and focus areas in gynecologic oncology education: A bibliometric and network visualization study","authors":"Xianye Zhu,&nbsp;Yingchao Zhao","doi":"10.1111/jog.70083","DOIUrl":"10.1111/jog.70083","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Gynecologic cancers, comprising 14.4% of newly diagnosed cancer cases in women globally, are substantial causes of both mortality and morbidity, with a profound impact on the quality of life (QoL) of survivors. Therefore, it is crucial to strengthen education for both healthcare providers and patients. However, there remains a limited amount of comprehensive, systematic analysis on global research trends and key developments in this area, so this study aims to investigate global research trends and key focus areas in gynecologic oncology education through bibliometric analysis and network visualization, providing data-driven support and valuable academic insights for future research.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Articles on gynecologic oncology education published between 2014 and 2024 were retrieved from the Web of Science Core Collection database. We used bibliometric software (VOSviewer and CiteSpace) for quantitative analysis of co-citation, co-authorship, and co-occurrence patterns, focusing on geographical distribution, key authors, references, and keywords.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Research in this field has grown modestly since 2014, with annual publications exceeding 10 only after 2018. The author's analysis indicates that Ignacio Zapardiel, Lisa Singer, Manchanda, Ranjit and others are the core authors in this field. Western nations such as the United States and Germany lead in publication volume and citation impact, while Asian countries rarely appear in leading rankings. Keyword analysis indicates a recent focus on “education” within training frameworks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Gynecologic oncology education remains nascent yet promising. Fostering international interdisciplinary collaboration—especially with Asian nations—is critical. Future priorities include high-fidelity bioprinting, intraoperative navigation systems, multicenter technology standardization, specialized sexual health rehabilitation, and culturally adapted interventions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility-Sparing Trachelectomy With Sentinel Node Mapping in Early-Stage Cervical Cancer: Oncological Safety and Obstetric Outcomes From a Single-Institution Study","authors":"Shinichi Togami,&nbsp;Nozomi Furuzono,&nbsp;Yusuke Kobayashi,&nbsp;Mika Fukuda,&nbsp;Shintaro Yanazume,&nbsp;Hiroaki Kobayashi","doi":"10.1111/jog.70091","DOIUrl":"10.1111/jog.70091","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Trachelectomy is a fertility-preserving surgical approach for early-stage cervical cancer. To enhance oncological safety, intraoperative sentinel lymph node (SN) evaluation has been incorporated. This study aimed to evaluate the long-term oncological and obstetric outcomes of trachelectomy with SN biopsy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We enrolled 53 patients who underwent trachelectomy with intraoperative SN assessment at Kagoshima University Hospital between 2014 and 2022. The preoperative and intraoperative eligibility criteria were strictly applied. Surgical and obstetric outcomes were evaluated, and recurrence-free survival (RFS) and overall survival (OS) were calculated using the Kaplan–Meier analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 78 candidates, 53 met all criteria and successfully underwent trachelectomy. The 5-year RFS and OS rates were both 98%. Bilateral SNs were detected in 98% of patients, and intraoperative SN biopsy-guided surgical decisions were made. Postoperative complications occurred in 6% of the patients. Of the 19 patients who attempted conception, 10 (53%) became pregnant, leading to 8 live births (five preterm, three term). In vitro fertilization and embryo transfer were used in 60% of the pregnancies. Pregnancy was associated with a high risk of preterm delivery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Trachelectomy with intraoperative SN biopsy is a feasible and safe treatment option for appropriately selected patients with early-stage cervical cancer. It offers excellent oncological outcomes and acceptable fertility potential. However, the risk of obstetric complications, particularly preterm births, remains high. Structured postoperative and perinatal management is crucial. Further prospective multicenter studies are warranted to validate and refine this approach.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Helicobacter pylori Infection Is a Risk Factor for Severe Hyperemesis Gravidarum Requiring Prolonged Hospitalization","authors":"Ryuhei Kurashina,&nbsp;Masafumi Toyoshima,&nbsp;Jun Ogawa,&nbsp;Youhei Tsunoda,&nbsp;Nozomi Ouchi,&nbsp;Mirei Yonezawa,&nbsp;Rintaro Sawa,&nbsp;Yoshimitsu Kuwabara,&nbsp;Shunji Suzuki","doi":"10.1111/jog.70099","DOIUrl":"10.1111/jog.70099","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This retrospective study investigated the relationship between <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection and prolonged hospitalization in patients with severe hyperemesis gravidarum (HG). We also aimed to identify other factors associated with extended hospital stays.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed data from 164 patients with severe HG. The patients were initially divided into two groups based on their anti-<i>H. pylori</i> IgG antibody status (positive vs. negative). Subsequently, a second analysis stratified all patients into a short-stay group (&lt; 21 days) and a long-stay group (≥ 21 days).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients who were positive for anti-<i>H. pylori</i> IgG antibodies had significantly longer hospital stays (median 24 vs. 15 days, <i>p</i> = 0.032). In a univariate analysis, anti-<i>H. pylori</i> IgG positivity, higher serum free thyroxine (FT4) levels, and strong urine ketone positivity were all significantly associated with long-term hospitalization. In the subsequent multivariate analysis, anti-<i>H. pylori</i> IgG positivity emerged as an independent risk factor for prolonged hospitalization (odds ratio 4.67, 95% CI 1.61–13.49, <i>p</i> = 0.004). Although strongly positive urine ketones were also associated with longer hospital stays (median 19 vs. 12 days, <i>p</i> = 0.001), this was not identified as an independent risk factor (odds ratio 2.169, 95% CI 0.97–4.85, <i>p</i> = 0.059).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings suggest that testing for anti-<i>H. pylori</i> IgG antibodies may help identify patients at a higher risk for a longer hospital stay due to severe HG. Pregnant women who test positive for anti-<i>H. pylori</i> IgG antibodies may benefit from closer monitoring. Additionally, these results raise the possibility that preconception care could be a preventive measure.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.70099","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pause for Reflection: Artificial Intelligence in Medical Writing and Patient Benefit","authors":"Shigeki Matsubara","doi":"10.1111/jog.70105","DOIUrl":"10.1111/jog.70105","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Trends and Determinants of Low-Dose Estrogen-Progestin Prescription in Japan During 2014–2022: An Ecological Study Using a Nationwide Claims Database","authors":"Keiko Takata,&nbsp;Mariko Ogawa,&nbsp;Toshifumi Takahashi","doi":"10.1111/jog.70093","DOIUrl":"10.1111/jog.70093","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to evaluate the trends and regional disparities in low-dose estrogen-progestin (LEP) prescription in Japan from 2014 to 2022 and the factors contributing to these disparities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>LEP prescription data were obtained from the National Health Insurance Claims and Specific Health Examination Database; the prescriptions per 1000 women aged 10–54 years were calculated. Trends were analyzed in terms of the overall volume, age group distribution, and formulation type. The regional distribution in 2022 was also examined; the factors influencing regional differences were identified using multiple regression analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>LEP prescriptions showed a significant annual increase (<i>p</i> &lt; 0.05), rising approximately five-fold over 9 years. A significant increase was observed in all age groups, except for those in their 50s (<i>p</i> &lt; 0.05). Ethinylestradiol 0.035 mg/norethisterone 1 mg (<i>p</i> &lt; 0.005) and ethinylestradiol 0.02 mg/drospirenone 3 mg (cyclic dosing regimen) (<i>p</i> &lt; 0.001) usage declined. Conversely, ethinylestradiol 0.02 mg/drospirenone 3 mg (continuous dosing regimen) and ethinylestradiol 0.02 mg/levonorgestrel 0.09 mg usage increased significantly (<i>p</i> &lt; 0.05). In 2022, regional disparities in LEP prescriptions reached a maximum of 2.7-fold. These disparities were not associated with the number of obstetricians and gynecologists and women's health specialists. However, the prescription of EE 0.02 mg/drospirenone 3 mg (continuous dosing regimen) showed a significant association with the number of women's health specialists (<i>p</i> = 0.002).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study provides the first comprehensive analysis of real-world LEP prescription patterns in Japan, revealing significant regional disparities.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-Amniotic Infection Prediction Score Based on Simple Maternal Information for Preterm Premature Rupture of Membranes","authors":"Yuko Oshima,&nbsp;Makoto Nomiyama,&nbsp;Keisuke Tsumura,&nbsp;Satoko Tsuda,&nbsp;Takeshi Ono,&nbsp;Yutaka Kozuma,&nbsp;Fumio Yamasaki,&nbsp;Yukiko Nakura,&nbsp;Itaru Yanagihara,&nbsp;Masatoshi Yokoyama","doi":"10.1111/jog.70100","DOIUrl":"https://doi.org/10.1111/jog.70100","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to develop and validate a predictive model for intra-amniotic infection in preterm premature rupture of membranes (PPROM) using simple maternal clinical parameters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective cohort study was conducted on pregnant women with PPROM between 22 + 0 and 35 + 6 weeks of gestation. The patients were categorized into development (2013–2017) and validation (2018–2023) cohorts. Intra-amniotic infection was defined as the microbial invasion of the amniotic cavity with intra-amniotic inflammation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 229 patients were analyzed, with 121 and 108 patients in the development and validation cohorts, respectively. A scoring system was established, assigning 1 point for gestational age of &lt; 32 weeks and white blood cell (WBC) count of ≥ 11 400/μL, and 3 points for C-reactive protein (CRP) level of ≥ 0.51 mg/dL. The areas under the receiver operating characteristic curve were 0.92 (95% confidence interval [CI], 0.87–0.98) and 0.86 (95% CI, 0.75–0.97) in the development and validation cohorts, respectively. The mean predicted probabilities were 2.6%, 8.7%, 24.9%, 53.6%, 80.1%, and 93.3% at scores of 0, 1, 2, 3, 4, and 5, respectively. The difference between the predicted and observed probabilities remained within 10% for all scores except for 3.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A predictive score for intra-amniotic infection in PPROM was developed and validated using the WBC count, CRP level, and gestational age, demonstrating high diagnostic accuracy. Further validation in diverse populations is necessary for broader clinical applicability.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}