Journal of Obstetrics and Gynaecology Research最新文献_第2页

Correction to "Overactive bladder symptom scores (OABSS) responsiveness before and after anticholinergic treatment in women with overactive bladder (OAB): The pilot study". 更正 "膀胱过度活动症（OAB）女性患者在抗胆碱能治疗前后的膀胱过度活动症状评分（OABSS）反应性：试点研究"。

IF 1.6 4区医学

Journal of Obstetrics and Gynaecology Research Pub Date : 2024-08-29 DOI: 10.1111/jog.16071

引用次数: 0

Cyclosporine A improves the binding of mouse embryos to fibronectin. 环孢素 A 可改善小鼠胚胎与纤维粘连蛋白的结合。

IF 1.6 4区医学

Journal of Obstetrics and Gynaecology Research Pub Date : 2024-08-27 DOI: 10.1111/jog.16046

Tian Shengnan, Zheng Mei, Wang Jiaxing, Li Dan, Ma YanLin, Yuanhua Huang

{"title":"Cyclosporine A improves the binding of mouse embryos to fibronectin.","authors":"Tian Shengnan, Zheng Mei, Wang Jiaxing, Li Dan, Ma YanLin, Yuanhua Huang","doi":"10.1111/jog.16046","DOIUrl":"https://doi.org/10.1111/jog.16046","url":null,"abstract":"Aim: The binding of integrin αvβ3 with endometrial fibronectin (FN) promotes the migration of preimplantation embryos in mice. We have previously shown that cyclosporine A (CsA) improves the adhesion and invasion of mouse preimplantation embryos. In this study, we evaluated the roles of calcium ions and downstream signaling factors in the binding of integrin αvβ3 to FN.Methods: Female Institute of Cancer Research (ICR) mice were superovulated and mated, and two-cell embryos were harvested from the oviducts and cultured to the blastocyst stage The adhesion and stretching growth of hatched embryos in laminin-coated dishes were evaluated, and integrinβ3 expression was determined using qPCR. Blastocytes were cultured with 0 or 1 <math> <semantics><mrow><mi>μM</mi></mrow> <annotation>$$ upmu mathrm{M} $$</annotation></semantics> </math> cyclosporine A (CsA) and the attachment of embryonic integrin αvβ3 to FN120 was observed using a fluorescent bead. To further determine the mechanism, the cells were also incubated with calcium ions and protein kinase C and calmodulin antagonists. The binding of integrin αvβ3 to FN120 was examined via confocal laser scanning microscopy.Results: The adhesion and stretching growth of peri-implantation embryos were greater and integrinβ3 expression was higher in the 1 μM CsA group than in the 0 μM CsA group (p < 0.05). When incubated with calcium ions and protein kinase C and calmodulin antagonists, the ability of peri-implantation embryos to bind to FN decreased; CsA treatment promoted this binding.Conclusion: This study revealed that CsA up - regulates integrinβ3 expression in peri - implantation embryos and promotes binding to FN via calcium ions, and protein kinase C, and calmodulin. These findings provide evidence supporting the beneficial effect of CsA on the peri - implantation embryo adhesion.","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Normal menstrual flow volume range and its characteristics measured from sanitary napkins in Japanese women: Discrepancy between measured and subjective menstrual flow volume. 通过卫生巾测得的日本女性正常月经量范围及其特征：测量值与主观月经量之间的差异。

IF 1.6 4区医学

Journal of Obstetrics and Gynaecology Research Pub Date : 2024-08-26 DOI: 10.1111/jog.16064

Shiota Atsuko, Teraoka Hiromi, Ishikawa Hiroki

{"title":"Normal menstrual flow volume range and its characteristics measured from sanitary napkins in Japanese women: Discrepancy between measured and subjective menstrual flow volume.","authors":"Shiota Atsuko, Teraoka Hiromi, Ishikawa Hiroki","doi":"10.1111/jog.16064","DOIUrl":"https://doi.org/10.1111/jog.16064","url":null,"abstract":"Aim: The 2018 International Federation of Gynecology and Obstetrics abnormal uterine bleeding System-1 defines menstrual flow volume on a 3-point scale based on subjective assessment. However, the normal flow range has not been established, and it is unclear whether subjective assessment is accurate. We investigated the normal menstrual flow volume range in Japanese women and whether the actual measured menstrual flow volume agreed with the subjective evaluation.Methods: We included female menstruating volunteers aged 18-49 years in this prospective observational study. Menstrual napkins were weighed before and after use for up to three cycles, and the values were recorded in an online diary.Results: Overall, 211 participants were recruited. All items were completed by 167 participants, and 497 menstrual cycles were included in the analysis. The median total menstrual flow volume per cycle for 497 cycles was 56.7 g. The 5th-95th percentile values ranged from 15.7 to 166.4 g. The mean value was 77.6 ± 99.6 g, with no significant differences according to age group. In the 25 cycles corresponding to heavy flow, that is, above the 95th percentile of measured flow volume, 92% were underrated as \"normal\" by subjective evaluation, and only 8% were correctly rated as \"heavy.\"Conclusions: Our results clarify the actual menstrual flow volume in the Japanese population; this will contribute toward making women aware of the normal range of menstrual flow volume, which may facilitate appropriate preconception care.","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Should the sex of the fetus be considered when administering antenatal corticosteroids to preterm fetuses? 在对早产儿使用产前皮质类固醇时，是否应考虑胎儿的性别？

IF 1.6 4区医学

Journal of Obstetrics and Gynaecology Research Pub Date : 2024-08-26 DOI: 10.1111/jog.16062

Erdal Şeker, Elvis Kraja, Maide Selin Çakır, Yasemin Ezgi Köstekçi, Mehmet Obut, Emel Okulu, Ömer Erdeve, Fatma Begüm Atasay, Saadet Arsan, Acar Koç

{"title":"Should the sex of the fetus be considered when administering antenatal corticosteroids to preterm fetuses?","authors":"Erdal Şeker, Elvis Kraja, Maide Selin Çakır, Yasemin Ezgi Köstekçi, Mehmet Obut, Emel Okulu, Ömer Erdeve, Fatma Begüm Atasay, Saadet Arsan, Acar Koç","doi":"10.1111/jog.16062","DOIUrl":"https://doi.org/10.1111/jog.16062","url":null,"abstract":"Aim: We aimed to determine whether the effect of antenatal corticosteroids (ANS) differs in male and female fetuses without anomalies born before 32 weeks in terms of mortality and short-term morbidity.Methods: This single-center retrospective study included infants born before 32 weeks' gestation and admitted to the neonatal intensive care unit between January 1, 2018, and December 31, 2020.Results: The study included 210 infants with a median gestational age of 28.6 weeks (24-31.6), a birth weight of 1065 g (445-2165), and an ANS use rate of 80%. Compared to female fetuses exposed to ANS, male fetuses exposed to ANS had a lower mortality rate (23% and 11%, respectively, p = 0.038), but there were no differences in intraventricular hemorrhage, retinopathy of prematurity, necrotizing enterocolitis, respiratory distress syndrome, and APGAR scores of 1st and 5th but an increased rate of bronchopulmonary dysplasia (moderate/severe) (p = 0.008). In addition, the mortality rate was similar in exposed and unexposed female fetuses (p = 0.850). Enzyme activities and steroid levels in the placenta might be different in male and female fetuses, which could explain the results of ANS administration.Conclusions: In our study, we have shown that ANS has no effect on mortality in female fetuses younger than 32 weeks. Future studies may focus on adjusting the administration of ANS based on fetal sex, altering the dose or taking fetal sex into account when performing ANS.","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Factors related to clearance of the small pelvic cavity during gynecologic laparoscopic surgery". 更正 "妇科腹腔镜手术中清理小盆腔的相关因素"。

IF 1.6 4区医学

Journal of Obstetrics and Gynaecology Research Pub Date : 2024-08-26 DOI: 10.1111/jog.16066

引用次数: 0

Granulomatous mastitis during pregnancy with sudden onset of gait difficulty and erythema nodosum: A case report and review of the literature. 妊娠期肉芽肿性乳腺炎伴有突然出现的步态困难和结节性红斑：病例报告和文献综述。

IF 1.6 4区医学

Journal of Obstetrics and Gynaecology Research Pub Date : 2024-08-26 DOI: 10.1111/jog.16067

Hideyuki Miyahara, Yusuke Kurokawa, Megumi Muto, Yuko Takao, Erina Iwanaga, Yutaro Mihara, Nao Fukushima, Toshiyuki Yoshizato, Naotake Tsuda

引用次数: 0

Gestational diabetes mellitus management according to ultrasound fetal growth versus strict glycemic treatment in singleton pregnancies: A systematic review and meta-analysis of clinical trials. 单胎妊娠中根据超声胎儿生长情况进行妊娠糖尿病管理与严格血糖治疗的比较：临床试验的系统回顾和荟萃分析。

IF 1.6 4区医学

Journal of Obstetrics and Gynaecology Research Pub Date : 2024-08-25 DOI: 10.1111/jog.16059

Ana M Fernández-Alonso, Angélica Monterrosa-Blanco, Álvaro Monterrosa-Castro, Faustino R Pérez-López

{"title":"Gestational diabetes mellitus management according to ultrasound fetal growth versus strict glycemic treatment in singleton pregnancies: A systematic review and meta-analysis of clinical trials.","authors":"Ana M Fernández-Alonso, Angélica Monterrosa-Blanco, Álvaro Monterrosa-Castro, Faustino R Pérez-López","doi":"10.1111/jog.16059","DOIUrl":"https://doi.org/10.1111/jog.16059","url":null,"abstract":"Aim: The objective of this meta-analysis was to evaluate obstetric outcomes in gestational diabetes mellitus (GDM) patients treated with flexible management based on intrauterine ultrasound fetal growth (FMIUFG) or strict maternal glycemic adjustment (SMGA).Methods: We performed a comprehensive systematic review of electronic databases for randomized clinical trials (RCTs) comparing obstetrics outcomes of singleton GDM patients managed according to FMIUFG or SMGA. The review protocol was registered in PROSPERO (CRD497888). Searches were conducted in PubMed, Embase, Cochrane, and LILACS. Primary outcomes were gestational age at delivery and birth weight. Random-effect model meta-analyses were used to minimize the effects of uncertainty associated with inter-study variability. Results are reported as standardized mean differences (SMDs) or as odds ratios (ORs) and their 95% confidence interval (CI). Heterogeneity between studies was estimated using the I2 statistic. The Cochrane Risk of Bias Scale was used to assess the quality of studies. There were five RCTs with low to moderate risk of bias, including 450 patients managed according to the FMIUFSG and 381 according to the SMGA.Results: The macrosomia (birthweight >4000 g) rate was lower in pregnancies managed according to FMIUFG than SMGA adjustments (OR: 0.34; 95%CI: 0.16, 0.71). There were no significant differences in hypertensive disorder, cesarean section, neonatal intensive care unit admission, and large newborn for gestational age rates.Conclusions: The macrosomia rate was lower in women managed with the FMIUFG. There were no significant differences in other obstetric and neonate outcomes.","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstetric outcomes of transabdominal cerclage: A retrospective observational study in Japan. 经腹宫颈环扎术的产科结果：日本的一项回顾性观察研究。

IF 1.6 4区医学

Journal of Obstetrics and Gynaecology Research Pub Date : 2024-08-25 DOI: 10.1111/jog.16063

Yoshifumi Kasuga, Shinji Tanigaki, Kohei Seo, Ayumi Harada, Yoshimitsu Kuwabara, Shinichi Ishioka, Mamoru Tanaka

{"title":"Obstetric outcomes of transabdominal cerclage: A retrospective observational study in Japan.","authors":"Yoshifumi Kasuga, Shinji Tanigaki, Kohei Seo, Ayumi Harada, Yoshimitsu Kuwabara, Shinichi Ishioka, Mamoru Tanaka","doi":"10.1111/jog.16063","DOIUrl":"https://doi.org/10.1111/jog.16063","url":null,"abstract":"Objective: This study aimed to investigate the obstetric outcomes of transabdominal cerclage (TAC) in Japan.Methods: Questionnaires on TAC were sent to 183 institutions performing high-quality perinatal management in Japan. As a first-step questionnaire, we asked whether TAC was performed between January 1, 2011, and December 31, 2022. In the second step of the questionnaire, the characteristics of all cases were asked from all institutions in which TAC was performed.Results: The response rate for the first survey was 59% (108/183). Of the 108 institutions, 27 performed TAC (25%) in 133 pregnancies. Of these 27 institutions, 19 responded to the second survey. One hundred twenty-five pregnancies were included in this study, five of which were aborted (gestational weeks <22 weeks), and 69 babies were born after 37 gestational weeks (55%). Eighty-two open abdominal cerclages were performed at 17 institutions and 43 laparoscopic TACs at three institutions. There were no differences in the age at TAC, gestational weeks at TAC, operative time of TAC, gestational weeks at delivery, incidence rate of second-trimester loss, or preterm delivery (before 37 gestational weeks) rate between the two groups. However, blood loss during open TAC was greater than that during laparoscopic TAC.Conclusion: TAC is a rare surgery for cervical insufficiency in Japan. TAC may be a safe and useful method for preventing second-trimester loss and preterm delivery in high-risk patients. TAC may also be a key option in Japan to improve perinatal outcomes in patients with cervical insufficiency.","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metformin enhances the survival ability of ovarian granulosa cells in polycystic ovary syndrome by promoting LINC00548 to suppress androgen receptor/klotho pathway. 二甲双胍通过促进LINC00548抑制雄激素受体/klotho通路提高多囊卵巢综合征卵巢颗粒细胞的存活能力

IF 1.6 4区医学

Journal of Obstetrics and Gynaecology Research Pub Date : 2024-08-21 DOI: 10.1111/jog.16060

Guangxin Pan, Sha Li, Guoping Xiong, Pei Zhang, Li Zhang, Yanru Yao, Gang Lei

{"title":"Metformin enhances the survival ability of ovarian granulosa cells in polycystic ovary syndrome by promoting LINC00548 to suppress androgen receptor/klotho pathway.","authors":"Guangxin Pan, Sha Li, Guoping Xiong, Pei Zhang, Li Zhang, Yanru Yao, Gang Lei","doi":"10.1111/jog.16060","DOIUrl":"https://doi.org/10.1111/jog.16060","url":null,"abstract":"Background: Metformin (Met) has been reported to play the key role in the pathogenesis of polycystic ovary syndrome (PCOS). However, the precise mechanisms underlying the actions of Met in PCOS remain incompletely understood. This study aimed to confirm the mechanism of Met interacting with a long non-coding RNA LINC00548 in PCOS.Methods: Ovarian granulosa cells (OGCs) were incubated 500 nM dihydrotestosterone (DHT) to construct PCOS in vitro model and then were treated 20 μM Met. A series of cell experiments including Cell Counting Kit-8, Terminal uridine nucleotide end labeling, and flow cytometry were performed to confirm the changes of OGC survival ability. Quantitative real-time polymerase chain reaction was conducted to determine the levels of LINC00548, whereas Western blotting was applied to determine the levels of androgen receptor (AR) and klotho.Results: Met improved the cell viability and suppressed cell apoptosis in DHT-treated OGCs. LINC00548 downregulated in DHT-treated OGCs was upregulated by Met, and its overexpression further enhanced the positive effects of Met on the survival ability of DHT-treated OGCs. In addition, Met could induce the upregulation of LINC00548 to suppress the activation of AR/klotho pathway in DHT-treated OGCs.Conclusion: Overall, this study discovers that Met enhances the survival ability of OGCs in PCOS by elevating LINC00548 expression to suppress AR/klotho pathway.","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in perinatal complications and serum hormone levels due to uterine endometrial preparation methods in frozen-thawed embryo transfer. 冷冻解冻胚胎移植中子宫内膜制备方法导致围产期并发症和血清激素水平的差异。

IF 1.6 4区医学

Journal of Obstetrics and Gynaecology Research Pub Date : 2024-08-21 DOI: 10.1111/jog.16058

Tatsuya Yoshihara, Yasuhiko Okuda, Maki Ogi, Dai Miyashita, Osamu Yoshino

{"title":"Differences in perinatal complications and serum hormone levels due to uterine endometrial preparation methods in frozen-thawed embryo transfer.","authors":"Tatsuya Yoshihara, Yasuhiko Okuda, Maki Ogi, Dai Miyashita, Osamu Yoshino","doi":"10.1111/jog.16058","DOIUrl":"https://doi.org/10.1111/jog.16058","url":null,"abstract":"Aim: In frozen-thawed embryo transfer (FET), differences in endometrial preparation methods affect the incidence of perinatal complications. However, the underlying causes are unclear. We aimed to investigate whether serum E2, P4 levels are associated with perinatal complications.Methods: This is a retrospective cohort study, involving 306 successful FET pregnancies from 2017 to 2022. Participants were divided into Natural Cycle (NC) and Hormone Replacement Cycle (HRC) group. We compared serum hormone levels, maternal backgrounds, and perinatal outcomes and complications. Furthermore, within the HRC group, serum hormone levels were compared for perinatal complications previously reported to show differences in incidence rates depending on the method of endometrial preparation.Results: HRC exhibited significantly higher serum E2 levels during the implantation period, but lower P4 levels during ovulation, implantation, and pregnancy test period compared with NC. HRC also had significantly higher rates of postpartum hemorrhage (PPH) and placenta accreta spectrum (PAS). There was no association found between perinatal complications more likely to occur in HRC and serum E2, P4 levels.Conclusions: In HRC, there were more occurrences of PPH and PAS. Although serum E2, P4 levels during FET did not correlate with perinatal complications.","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0