Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Birth and pregnancy numbers decreased during the COVID-19 pandemic in Japan: A time series analysis with the ARIMA model","authors":"Keiko Yamamoto,&nbsp;Koji Uchiyama,&nbsp;Yoshiko Abe,&nbsp;Nobuko Takaoka,&nbsp;Yasuo Haruyama,&nbsp;Gen Kobashi","doi":"10.1111/jog.16202","DOIUrl":"10.1111/jog.16202","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The long-term effects of the COVID-19 pandemic on birth and pregnancy trends in Japan remain unclear. Although major sporting events are usually followed by an increase in births 9 months later, Japan's fifth wave of COVID-19 occurred during the Olympics held in Japan during the summer of 2021. In this study, we analyzed how the number of births and pregnancies changed during the COVID-19 pandemic and large-scale events in Japan.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We utilized monthly vital statistical data from birth certificates spanning the years 2010 to 2022. Our analysis followed the identification, estimation, and forecasting stages of autoregressive integrated moving average (ARIMA) modeling. We found the ARIMA (1, 12, 12) model to be adequate for forecasting the monthly number of births.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Comparing actual birth data from 2020 to 2022 with our forecast, we observed a significant decrease in births across all of Japan, urban residential areas, and 13 prefectures—primarily metropolitan regions—in January 2021 and May 2022. We also observed a decrease in pregnancy notifications in May 2020, May 2021, and October 2021. The decrease in births in May 2022 in Japan aligns with the decrease in pregnancy notifications 8 months earlier in October 2021.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Although major sporting events are expected to lead to an increase in the number of births approximately 9 months later, the number of births decreased in May 2022 during the fifth wave of the COVID-19 pandemic in Japan. These findings suggest that the number of pregnancies and births should be monitored in future pandemics with particular attention to fertility trends.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes after 2-year follow-up of transvaginal radiofrequency ablation of symptomatic uterine fibroids","authors":"Ángel Santalla-Hernández,&nbsp;Mariña Naveiro-Fuentes,&nbsp;María Setefilla López-Criado,&nbsp;Roi Naveiro-Flores,&nbsp;Jorge Fernández-Parra","doi":"10.1111/jog.16216","DOIUrl":"10.1111/jog.16216","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of this study was to evaluate the efficacy after 2 years follow-up of transvaginal radiofrequency ablation (TVRA) to treat myomas, and to identify factors predictive of the response to the treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a prospective cohort study of a 2-year follow-up of 65 patients who underwent TVRA for the treatment uterine fibroids at Virgen de las Nieves University Hospital in Granada, Spain. Ultrasound mean fibroid volume, symptom severity scale, total bleeding days, complications, pregnancy outcomes were recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Statistically significant improvements in symptoms and bleeding were observed at 6, 12, and 24 months after the procedure. The mean myoma volume (cc) was significantly lower (<i>p</i> &lt; 0.05) at 12 and 24 months, with a mean reduction in myoma volume of more than 80% and 60%, respectively. After a 24-month follow-up, 5 patients (7.7%) required additional surgical treatment to control symptoms. Patient age (&gt;40 years), initial myoma size, and the timing of radiofrequency were identified as factors related to outcomes in the bivariate analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Transvaginal radiofrequency ablation is an effective and safe technique for the treatment of myomas after 2 years of follow-up, which improves the symptoms of the patients and decreases the final volume of the myoma.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometrial cancer with para-aortic lymph node metastasis following medroxyprogesterone acetate therapy: A case report","authors":"Miku Nakamura,&nbsp;Yoshifumi Takahashi,&nbsp;Takahiro Koyanagi,&nbsp;Yuji Takei,&nbsp;Hiroyuki Fujiwara","doi":"10.1111/jog.16217","DOIUrl":"10.1111/jog.16217","url":null,"abstract":"<p>Medroxyprogesterone acetate (MPA) is a promising fertility-sparing treatment for early stage endometrial cancer; however, it has a high recurrence rate and is inferior to surgery. Although the site of recurrence is mostly the endometrium, we here report a case of metastatic recurrence to the para-aortic lymph node with endometrial recurrence despite a careful follow-up. A 31-year-old woman was diagnosed with grade 1 endometrioid carcinoma, stage IA without myometrial invasion. She requested fertility-sparing treatment and underwent a 48-week MPA therapy with complete remission. Follow-up continued with ultrasonography and endometrial biopsy every 3 and 6 months, respectively; however, at 10 months following MPA therapy, cancer recurrence was detected in the endometrium and para-aortic lymph node, requiring hysterectomy, bilateral adnexectomy, and lymph node dissection, followed by paclitaxel/carboplatin chemotherapy. This case report highlights that lymph node recurrence can develop despite careful follow-up following complete remission with MPA therapy for stage IA endometrial cancer.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of deep vein thrombosis in pregnant women by platelet indices: A retrospective case–control study","authors":"Serap Topkara,&nbsp;Şevki Çelen","doi":"10.1111/jog.16212","DOIUrl":"10.1111/jog.16212","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aimed to investigate the predictive value of the platelet indices for the diagnosis of acute deep vein thrombosis (DVT) in pregnant women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Pregnant women aged 20–45 years who presented to the emergency room with leg pain and edema and underwent bilateral lower extremity venous Doppler examination for DVT were included in the study. Platelet large cell ratio (P-LCR), platelet distribution width (PDW) and mean platelet volume (MPV) values, which provide information on current platelet activity in the hemogram parameters recorded at first presentation in the emergency department, were analyzed between the two groups. Pregnant women with a history of venous thromboembolism, anticoagulant medication, heart disease, cancer, essential thrombocytopenia, gestational thrombocytopenia, pulmonary embolism, and multiple pregnancies were excluded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 125 participants were included in the study. Acute DVT was diagnosed in 37 participants using venous Doppler of the lower extremities. In the remaining 88 patients, the diagnosis of DVT was excluded. There was no significant difference between the groups in terms of age, body mass index, parity, and gestational age at diagnosis. Although platelet counts were similar between groups, P-LCR, PDW, and MPV values, which provide information on platelet shape and volume, were statistically significantly lower in Group DVT (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>According to this study, low MPV, PDW and P-LCR values in pregnant women can be evaluated as independent markers in the diagnosis of acute DVT or these markers can be included in the DVT scoring system for pregnant women.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing oocyte competence in patients with polycystic ovarian syndrome: A microfluidic study on the effects of follicular fluid meiosis-activating sterol in in vitro oocyte maturation","authors":"Hossein Torkashvand,&nbsp;Ronak Shabani,&nbsp;Tayebe Artimani,&nbsp;Shamim Pilehvari,&nbsp;Mahdi Moghimi,&nbsp;Leila Torkashvand,&nbsp;Mahnaz Ashrafi,&nbsp;Mehdi Mehdizadeh","doi":"10.1111/jog.16203","DOIUrl":"10.1111/jog.16203","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the efficacy of a microfluidic culture system supplemented with follicular fluid meiosis-activating sterol (FF-MAS) on the maturation of immature oocytes in patients with polycystic ovarian syndrome (PCOS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 438 germinal vesicle oocytes from 163 PCOS patients were included. Oocytes were divided into five groups: (1) cultured in static drops without FF-MAS, (2) cultured in static drops with FF-MAS, (3) cultured in a microfluidic device without FF-MAS, (4) cultured in a microfluidic device with FF-MAS for the first 2 h, and (5) cultured in a microfluidic device with FF-MAS for 24 h. Maturation, fertilization, and embryo development rates were assessed, alongside gene expression analysis using quantitative real-time PCR. Ultrastructural analysis was performed using transmission electron microscopy (TEM).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The maturation rates for oocytes in groups 1 to 5 were 36%, 48%, 42%, 64%, and 65%, respectively, with groups 4 and 5 showing significant increases (<i>p</i> &lt; 0.05). Fertilization rates were higher in groups 4 and 5 (p &lt; 0.05). High-quality embryo formation rates were significantly higher in groups 3, 4, and 5. Gene expression analysis indicated enhanced expression of BRCA1 and TP53 in the dynamic culture groups. Ultrastructural analysis showed improved mitochondrial integrity and cytoplasmic maturation in the dynamic groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The dynamic microfluidic culture system with FF-MAS supplementation significantly enhances oocyte maturation and embryo quality in PCOS patients by closely mimicking the natural in vivo environment. This approach shows promise for optimizing in vitro oocyte maturation and improving fertility outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Re: Gulseren V, Gungorduk K, Uyar BS, Ozdemir IA. Is single port laparoscopy or vaginal natural orifice transluminal endoscopic surgery the better option for salpingo-oophorectomy? J Obstet Gyaecol Res 2024; 50: 2147–52","authors":"Zachary Penny,&nbsp;Olushola Ariyo,&nbsp;Wai Yoong","doi":"10.1111/jog.16215","DOIUrl":"10.1111/jog.16215","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomograph of cancer-specific survival in elderly patients with endometrial cancer based on SEER database","authors":"Fanghua Ma,&nbsp;Jiesheng Huang","doi":"10.1111/jog.16214","DOIUrl":"10.1111/jog.16214","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aims to identify prognostic factors for elderly patients with endometrial cancer and to develop a nomogram for predicting cancer-specific survival in this population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Clinicopathological data of elderly patients diagnosed with endometrial cancer between 2004 and 2015 were extracted from the SEER database. Patients were randomly assigned to either a training cohort or a validation cohort at a ratio of 7:3. Univariate and multivariable Cox regression analyses were performed to identify independent prognostic factors. A nomogram was then constructed based on these factors, and its predictive accuracy and discriminative ability were assessed using the C-index, receiver operating characteristic (ROC), and calibration curve.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Multivariate analysis identified age, marital status, grade, Federation of International of Gynecology and Obstetrics, surgery, chemotherapy, radiation, and tumor size as independent prognostic factors for elderly patients with endometrial carcinoma. Nomograms derived from these factors demonstrated excellent calibration and discrimination. The C-indexes were 0.83 for the training set and 0.82 for the validation set. The area under the curve (AUC) values for the training set were 0.88, 0.87, and 0.86 at 1, 3, and 5 year respectively. Corresponding AUC values for the validation set were 0.89, 0.86, and 0.86. Calibration curves for both cohorts demonstrated close alignment with the diagonal, indicating robust agreement between nomogram predictions and actual outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A novel nomogram has been developed for personalized prognosis assessment in elderly patients with endometrial carcinoma, aiming to enhance tailored treatment strategies and clinical management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hysteroscopy combined with laparoscopy in the diagnosis and treatment of omentum majus incarceration secondary to uterine perforation: A case report and literature review","authors":"Xiaolin Li,&nbsp;Jiandong Hu,&nbsp;Jing Li,&nbsp;Zhonge Tao,&nbsp;Quanxin Qu,&nbsp;Fenge Li","doi":"10.1111/jog.16213","DOIUrl":"10.1111/jog.16213","url":null,"abstract":"<p>Cervical dilatation, uterine evacuation, and curettage (D&amp;E&amp;C) are common gynecological procedures for abortion, yet they carry risks of complications such as uterine perforation and intra-abdominal organ incarceration. Here, we report a rare case of a breastfeeding patient who had an embedded abdominal greater omentum in the anterior wall of the uterus and into the uterine cavity during D&amp;E&amp;C. We used combined hysteroscopic and laparoscopic treatment for this case and successfully removed the embedded greater omentum. Our experience underscores the importance of vigilant intraoperative monitoring and prompt management to prevent serious complications like infection and bowel injury. In conclusion, hysteroscopic and laparoscopic combination treatment can be a preferred approach to avoid serious adverse outcomes for uterus perforation patients who developed omentum majus incarceration.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Th1, Th2, Th17, and Treg cell levels and imbalance with recurrent spontaneous abortion: A meta-analysis","authors":"Yuan Li,&nbsp;Shuxia Chen,&nbsp;Jiecheng Yang,&nbsp;Kejuan Zhang,&nbsp;Xin Feng,&nbsp;Chao Sun,&nbsp;Qiang Feng,&nbsp;Zhe Li","doi":"10.1111/jog.16207","DOIUrl":"10.1111/jog.16207","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Abnormal levels and imbalances of T cell subsets are common in recurrent spontaneous abortion (RSA) patients, but most studies have small sample sizes, and comprehensive evaluations are lacking. Therefore, this meta-analysis aimed to comprehensively investigate T cell subsets and their ratios in RSA patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Four databases (PubMed, EMBASE, Web of Science, and Cochrane Library databases) were searched until 10 January 2024. T helper 1 (Th1), Th2, Th1/Th2 ratio, Th17, regulatory T (Treg), Treg/Th17 ratio, and the correlation between Th17 and Treg were considered endpoint indexes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-six studies involving 1143 RSA women (RSA group) and 863 healthy women (healthy control group) were included. Th1 (standardized mean difference [SMD] = 0.603%; 95% confidence intervals [CI]: 0.406%, 0.800%; <i>p</i> &lt; 0.001), Th1/Th2 ratio (SMD = 0.838; 95% CI: 0.364, 1.312; <i>p</i> = 0.001), and Th17 (SMD = 1.047%; 95% CI: 0.734%, 1.360%; <i>p</i> &lt; 0.001) increased; Th2 (SMD = −0.719%; 95% CI: −1.263%, −0.174%; <i>p</i> = 0.010), Treg (SMD = −1.176%; 95% CI: −1.755%, −0.596%; <i>p</i> &lt; 0.001) and Treg/Th17 ratio (SMD = −0.978; 95% CI: −1.576, −0.381; <i>p</i> = 0.001) reduced in RSA group versus healthy control group. Th17 were inversely correlated with Treg in RSA patients (Correlation coefficient = −0.488; 95% CI: −0.726, −0.145; <i>p</i> = 0.019). The risk of bias was relatively low. There was no publication bias for Th1, Th2, or Th1/Th2 ratio; publication biases for other outcomes were corrected by the trim-and-fill method. Sensitivity analyses showed relatively high robustness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Th1, Th1/Th2 ratio, and Th17 are elevated, while Th2, Treg, and Treg/Th17 ratio are reduced in RSA patients. Meanwhile, Th17 was inversely correlated with Treg in these patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPRESSION OF CONCERN: Combined Metformin and Clomiphene Citrate Versus Laparoscopic Ovarian Diathermy for Ovulation Induction in Clomiphene-Resistant Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial","authors":"","doi":"10.1111/jog.16206","DOIUrl":"10.1111/jog.16206","url":null,"abstract":"<p><b>EXPRESSION OF CONCERN</b>: <span>H. A. Hashim</span>, <span>N. El Lakany</span>, <span>L. Sherief</span>, “ <span>Combined Metformin and Clomiphene Citrate Versus Laparoscopic Ovarian Diathermy for Ovulation Induction in Clomiphene-Resistant Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial</span>,” <i>The Journal of Obstetrics and Gynaecology Research</i> <span>37</span>, no. <span>3</span> (<span>2011</span>): <span>169</span>–<span>177</span>, https://doi.org/10.1111/j.1447-0756.2010.01383.x.</p><p>This Expression of Concern is for the above article, published online on 28 November 2010, in Wiley Online Library (http://onlinelibrary.wiley.com/), and has been issued by agreement between the journal Editor-in-Chief, Hiroaki Kajiyama; and John Wiley &amp; Sons, Australia, Ltd. The Expression of Concern has been agreed upon following concerns raised by a third party and further investigation by Wiley's Integrity Assurance and Case Resolution team which revealed concerns about the validity of the statistical analysis and the data presented in the article. An institutional investigation at Mansoura University into the reliability of the published clinical trial was requested in 2021. In response to inquiries by the publisher, the authors have stated that the original data are no longer available and that their data presented in this article are valid. The author previously provided a letter from Mansoura University, dated March 17, 2012, which confirms the author did work and publish studies between 2009 and 2012 at the institute. In 2014, an internal investigation conducted by professors affiliated with Mansoura University reported serious inconsistencies in the research reported in this article. However, the publisher was unsuccessful in receiving a direct response from Mansoura University with regard to the current investigation, despite our attempts. The journal has decided to issue an Expression of Concern to alert the readers as the authenticity of the data could not be confirmed. The authors disagree with the Expression of Concern.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}