Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Research progress on the impact of intravenous remifentanil used for labor analgesia on parturient women and infants","authors":"Lingfei Pu,&nbsp;jia Lou,&nbsp;Mochi Guo","doi":"10.1111/jog.16365","DOIUrl":"https://doi.org/10.1111/jog.16365","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Remifentanil's safety in labor analgesia is as yet unknown, despite its special pharmacological characteristics, which include a strong analgesic impact, quick onset, and brief duration of action. This paper aims to offer a thorough analysis of the effects on pregnant women and infants of intravenous remifentanil used for labor analgesia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Based on the literature, the study divides the maternal system into many systems and discusses the effects of remifentanil on each. In contrast to the use of remifentanil during a general anesthesia cesarean delivery, we show the effects of an intravenous remifentanil analgesia pump on infants. Instead of making broad generalizations, we describe how different analgesic pump modes may influence maternal pain control.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Remifentanil's favorable benefits on the mother are mostly focused on pain control and the labor process, whereas its negative effects are primarily focused on the influence on breathing and sedation levels. Currently, it is widely regarded to have no substantial effect on the cardiovascular system. It is widely regarded as safe for infants, and current study focuses on its short-term effects on them. Of course, the setting of the analgesic pump plays a vital part in the whole process.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>As an alternative to labor analgesia, remifentanil can be used. However, to prevent its harmful effects on expectant mothers and newborns, we advise adopting some safety measures.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncommon postpartum delayed hemolytic transfusion reaction caused by anti-C antibodies: A rare presentation without prior risk factors","authors":"Takehiko Mitsuyama,&nbsp;Saki Takahashi,&nbsp;Emi Kondo,&nbsp;Toshitaka Mutoh,&nbsp;Kosuke Kawakami,&nbsp;Toshiyuki Yoshizato","doi":"10.1111/jog.16362","DOIUrl":"https://doi.org/10.1111/jog.16362","url":null,"abstract":"<p>Delayed hemolytic transfusion reaction (DHTR) is a rare post-transfusion complication, typically involving extravascular hemolysis. We present an unusual case of postpartum DHTR caused by anti-C antibodies in a 35-year-old Japanese woman, gravida 2, para 1, with no history of transfusion, alloimmunization, or underlying hemoglobinopathy. The patient developed dark-colored urine on postpartum day 25, 12 days after receiving a blood transfusion for hemorrhage due to placenta accreta spectrum. Laboratory findings revealed indirect hyperbilirubinemia, elevated lactate dehydrogenase, low haptoglobin, and hemoglobinuria, indicating concurrent extravascular and intravascular hemolysis. DHTR was confirmed by the detection of anti-C antibodies and the presence of C-antigen-positive transfused red cells. Maternal sensitization likely resulted from subclinical fetomaternal transfusion, with an immune response triggered post-transfusion. This case highlights the diagnostic challenges of DHTR in the postpartum setting, emphasizing the importance of post-transfusion antibody screening and the need for heightened awareness of unexplained fever as a potential early indicator.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenesis and MRI findings in two cases of seromucinous borderline tumors coexisting with carcinoma in endometriotic cysts: Case reports and literature review","authors":"Mayumi Takeuchi,&nbsp;Kenji Matsuzaki,&nbsp;Yoshimi Bando,&nbsp;Masato Nishimura,&nbsp;Masafumi Harada","doi":"10.1111/jog.16368","DOIUrl":"https://doi.org/10.1111/jog.16368","url":null,"abstract":"<p>Seromucinous borderline tumors (SMBTs) generally have a favorable prognosis, and fertility-preserving surgery may be indicated. However, SMBT may occasionally coexist with carcinoma, necessitating careful management. This report presents two cases of SMBT coexisting with carcinoma within endometriotic cysts and reviews pathogenesis mechanisms with MRI-pathological correlations. In both cases, SMBT components appeared as papillary or nodular projections with prominent high signal intensity on T2WI, no diffusion restriction on DWI, and gradual, weak enhancement on dynamic contrast-enhanced (DCE) MRI. In contrast, coexisting carcinoma components showed intermediate signal intensity on T2WI, diffusion restriction on DWI, and rapid, intense enhancement on DCE-MRI. As it affects prognosis and treatment strategy, assessing the coexistence of carcinoma with SMBT is essential. This is the first report to demonstrate the usefulness of multiparametric MRI, including DWI and DCE-MRI, in evaluating SMBT and coexisting carcinoma in endometriotic cysts.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective observational study of changes in uterine fibroid blood flow and fibroid diameter after administration of gonadotropin-releasing hormone agonists and antagonists using superb microvascular imaging","authors":"Yudai Tanaka,&nbsp;Hiroaki Fujita,&nbsp;Reiko Kitayama,&nbsp;Minako Katano,&nbsp;Eri Nakano,&nbsp;Naoki Yoshikawa,&nbsp;Aya Shiraiwa,&nbsp;Kana Hirayama,&nbsp;Akane Takaya,&nbsp;Reiko Numazaki,&nbsp;Yuki Furusawa,&nbsp;Yoshihiro Nishijima,&nbsp;Eri Obiya","doi":"10.1111/jog.16361","DOIUrl":"https://doi.org/10.1111/jog.16361","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The relationship between the changes in fibroid blood flow and fibroid diameter during the administration of GnRH agonists and antagonists was examined using superb microvascular imaging (SMI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Changes in the maximum fibroid blood flow and diameter at weeks 0, 2, 4, and 8 were compared between the relugolix, a GnRH antagonist, and leuprolide, a GnRH agonist, groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Data were collected for 16 fibroids from 12 patients in the relugolix group and 12 fibroids from 9 patients in the leuprorelin group. A significant decrease was observed in the fibroid diameter at 8 weeks in the relugolix group, but no significant change was observed at any time point in the leuprorelin group. In the relugolix group, a significant correlation were observed between changes in blood flow at 2 weeks and fibroid diameter changes at 2 and 4 weeks, and between changes in blood flow at 4 weeks and fibroid diameter changes at 4 weeks. No significant correlation was observed in the leuprorelin group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In the treatment of uterine fibroids with relugolix, a reduction in fibroid blood flow assessed by SMI may suggest a subsequent reduction in fibroid size. These results provide useful insights when making the decision whether or not to continue relugolix administration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16361","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The peripheral cysts sign of ovarian thecoma-fibroma groups: Incidence and diagnostic value","authors":"Shulin Ma,&nbsp;Huanhuan Su,&nbsp;Yuan Chen,&nbsp;Mengya Sun,&nbsp;Guanglei Tang,&nbsp;Ruling Xu,&nbsp;Xuhui Zhou,&nbsp;Chang Li,&nbsp;Jian Guan","doi":"10.1111/jog.16369","DOIUrl":"https://doi.org/10.1111/jog.16369","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To investigate the incidence of the peripheral cysts sign of ovarian thecoma-fibroma groups (OTFGs), and to discuss the value of the peripheral cysts sign in the diagnosis of OTFGs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 112 patients with surgically proven fibromas and fibrothecomas were screened consecutively from January 2016 to December 2022. Peripheral cysts were recognized in 25 patients (Group A) but were absent in the remaining 87 patients (Group B). Clinical data (including age, menopausal state, incidence of vaginal bleeding, and thickening of the endometrium) were recorded and compared between the two groups. Preoperative images of Group A and 50 matched patients with other ovarian solid and cystic tumors were combined (test group, 75 patients) and reviewed by two radiologists before and after learning about the sign. The diagnostic accuracy of OTFGs with peripheral cysts was compared.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Preoperative imaging revealed that 22.3% (25/112) of patients with OTFGs presented with peripheral cysts. Age (56.4 ± 15.1 years vs. 43.3 ± 16.2 years, <i>p</i> = 0.02), postmenopausal status (84% vs. 48%, <i>p =</i> 0.002), and presence of thickening of the endometrium (39% vs. 7%, <i>p =</i> 0.001) were significantly different between Groups A and B. The diagnostic accuracy of OTFGs was significantly improved after learning about the sign [radiologist 1, 16% (4/25) vs. 84% (21/25), <i>p</i> &lt; 0.001; radiologist 2, 32% (8/25) vs. 88% (22/25), <i>p</i> &lt; 0.001, respectively].</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The presence of peripheral cysts was not uncommon in patients with OTFGs, especially in postmenopausal patients. Familiarity with the sign could help avoid misdiagnosing solid and cystic-like ovarian OTFGs as other ovarian solid and cystic tumors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antenatal corticosteroid treatment for women with hypertensive disorders of pregnancy: A population-based study in Japan","authors":"Takafumi Ushida,&nbsp;Kazuya Fuma,&nbsp;Satoru Katsuki,&nbsp;Sho Tano,&nbsp;Seiko Matsuo,&nbsp;Kenji Imai,&nbsp;Hiroaki Kajiyama,&nbsp;Tomomi Kotani","doi":"10.1111/jog.16364","DOIUrl":"https://doi.org/10.1111/jog.16364","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to evaluate the current antenatal corticosteroid (ACS) treatment practices for hypertensive disorders of pregnancy (HDP) in Japan, by evaluating annual trends and identifying clinical disparities and factors influencing non-administration of ACS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective population-based study was conducted using the Japanese Perinatal Research Network Database from 2013 to 2022. We analyzed ACS administration rates over time, across facility types, and the timing of delivery. Factors influencing non-administration were identified using univariate and multivariate logistic regression analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>ACS administration rates among patients with HDP nearly doubled over the past decade, reaching 64.0% in 2022. Approximately 70% of patients with HDP who received ACS delivered before 34 weeks of gestation; however, only 30% achieved the optimal administration-to-birth interval of 48 h to 7 days. ACS administration rates in patients with HDP differed by facility type: 67.8% (1641/2419) in general perinatal medical centers, 60.5% (1107/1830) in regional perinatal medical centers, and 39.7% (23/58) in non-perinatal medical centers. Factors contributing to non-administration included smoking during pregnancy, eclampsia, placental abruption, HELLP syndrome, regional perinatal medical centers, non-perinatal medical centers, and gestational hypertension. Conversely, conditions such as fetal growth restriction, threatened preterm labor, and preterm premature rupture of membranes were associated with higher rates of ACS administration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Although ACS administration rates in patients with HDP have improved over time, challenges remain in achieving optimal administration timing and addressing facility-based disparities. To improve administration rates, clinicians should increase awareness of ACS treatment and proactively manage HDP-related emergencies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16364","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tenofovir exerts antiviral effects in pregnant women with chronic hepatitis B by influencing the expression of miR-21-5p","authors":"Lei Zhang,&nbsp;Juan Du,&nbsp;Lan Shao,&nbsp;Cuili Yang,&nbsp;Yu Wang,&nbsp;Zhongfu Mo,&nbsp;Jinyu Gu","doi":"10.1111/jog.16355","DOIUrl":"https://doi.org/10.1111/jog.16355","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>In pregnant women with chronic hepatitis B (CHB), tenofovir (TDF) has demonstrated significant efficacy in disrupting the replication of the hepatitis B virus (HBV) and in preventing mother-to-child transmission (MTCT). This study seeks to elucidate the role of miR-21-5p in mediating the antiviral effect of TDF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Initially, the levels of miR-21-5p in pregnant women with and without CHB were compared by RT-qPCR assay. Subsequently, a comparison was made between the levels of HBV and miR-21-5p prior to and following treatment with TDF. Moreover, the correlation between miR-21-5p levels and HBV DNA, HBsAg or HBeAg was analyzed by Pearson correlation analysis. Lastly, HBV-infected huh-7 cells were cultured in vitro. Then, RT-qPCR and ELISA assays were conducted to investigate the influence of modulating miR-21-5p levels on HBV replication.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>miR-21-5p levels were significantly increased in CHB pregnant women. Following treatment with TDF, HBV was effectively controlled. More crucially, TDF led to a reduction in miR-21-5p levels. The level of miR-21-5p exhibited a positive correlation with HBV DNA, HBsAg and HBeAg. In cell experiments, the inhibition of miR-21-5p resulted in a significant decrease in levels of HBV DNA, HBsAg, and HBeAg. Conversely, overexpression of miR-21-5p yielded opposing results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In pregnant women with CHB, TDF may inhibit HBV replication by inhibiting the expression of miR-21-5p. This mechanism contributes to the mitigation of infection exacerbation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometriosis-related infertility focusing on mitochondrial DNA damage and its repair mechanism: Considering treatment strategies","authors":"Hiroshi Kobayashi,&nbsp;Shogo Imanaka","doi":"10.1111/jog.16358","DOIUrl":"https://doi.org/10.1111/jog.16358","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Endometriosis is a chronic gynecological condition characterized by persistent inflammation and frequently associated with dysmenorrhea and infertility. The success rate of assisted reproductive technology (ART) in individuals with endometriosis is often reported to be suboptimal. This review consolidates recent insights into mitochondrial DNA (mtDNA) damage and repair mechanisms in endometriosis patients and examines prospective therapeutic strategies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>For this narrative review, an extensive search of electronic databases was undertaken to identify relevant studies published up to August 31, 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In oocytes and granulosa cells from endometriosis patients, elevated levels of reactive oxygen species (ROS), driven by hypoxia and oxidative stress, contribute to the accumulation of mtDNA mutations. mtDNA repair is primarily dependent on the base excision repair (BER) pathway, mediated by poly(ADP-ribose) polymerase (PARP-1), due to a deficiency in double-strand break repair mechanisms. Upon mtDNA damage, PARP-1 activates single-strand break repair, utilizing nicotinamide adenine dinucleotide (NAD⁺) as a substrate. This process depletes ATP and leads to mitochondrial dysfunction in oocytes and granulosa cells. Such mitochondrial impairment may underlie the reduced efficacy of ART in endometriosis patients. Therapeutic interventions aimed at enhancing mitochondrial function, particularly by increasing mitochondrial NAD⁺ levels, represent a promising approach to addressing endometriosis-associated infertility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>mtDNA mutations and defective repair pathways in endometriosis are key contributors to mitochondrial dysfunction, which compromises ART success. This review highlights the potential of mitochondrial function-enhancing therapies as innovative strategies for improving reproductive outcomes in patients with endometriosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of pregnant HBV/HCV carriers and status of their internal medicine consultation: A nationwide survey in Japan","authors":"Manabu Ogoyama,&nbsp;Shunji Suzuki,&nbsp;Shin-ichi Hoshi,&nbsp;Akihiko Sekizawa,&nbsp;Yoko Sagara,&nbsp;Isamu Ishiwata,&nbsp;Tadaichi Kitamura","doi":"10.1111/jog.16351","DOIUrl":"https://doi.org/10.1111/jog.16351","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The present study investigated the prevalence of pregnant hepatitis B (HBV) and hepatitis C (HCV) carriers and their internal medicine consultation rates in Japan.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A questionnaire was sent to 1931 delivery facilities regarding their delivery management policies and care of pregnant HBV and HCV carriers who delivered between January and December 2023, including internal medicine consultation rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Responses were received from 1077 facilities (55.8%). The prevalence of HBV was 0.14% in Japanese women (406/288847) and 3.00% (196/6527) in non-Japanese women. The prevalence of HBV in 12 Japanese teenagers (≤19 years) was 0.53%, which was significantly higher than that in adult pregnant women (0.14%) (<i>p</i> &lt; 0.001). HBe antigen was positive in 12.6% of pregnant HBV carriers. The overall prevalence of HCV was 0.23% (684/295374), with similar rates in Japanese and non-Japanese women (0.23% vs. 0.31%), and 3.1% (21/684) had high HCV-RNA levels. Internal medicine consultations were performed on 64.8% (295/455) of known HBV carriers before pregnancy and on 66.7% (98/147) of those diagnosed during pregnancy. Regarding HCV, consultation rates were 10.5% (68/645) before pregnancy and 69.2% (27/39) during pregnancy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The prevalence of pregnant hepatitis virus carriers in Japan is approximately 0.2% for both HBV and HCV, with a high HBV rate in teenagers. Only 60%–70% of patients receive proper internal medicine consultations, highlighting the need for increased awareness among patients, physicians, and healthcare systems.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16351","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defecation disorder after anterior pelvic exenteration","authors":"Daiki Nishiyama,&nbsp;Sachiko Kitamura,&nbsp;Koji Yamanoi,&nbsp;Ryusuke Murakami,&nbsp;Masumi Sunada,&nbsp;Mana Taki,&nbsp;Akihito Horie,&nbsp;Ken Yamaguchi,&nbsp;Junzo Hamanishi,&nbsp;Yuki Kita,&nbsp;Masaki Mandai","doi":"10.1111/jog.16353","DOIUrl":"https://doi.org/10.1111/jog.16353","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Anterior pelvic exenteration preserves rectal function. However, we observed postoperative defecation disorders, mainly frequent, divided, and watery stools, that are not transient and persist even after hospital discharge. No reports of defecation problems after anterior pelvic exenteration for gynecological malignancies exist. Therefore, we evaluated defecation status after anterior pelvic exenteration for gynecological malignancies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sixteen patients who underwent anterior pelvic exenteration in our department between 2012 and 2022 were included. For comparison, 132 radical hysterectomy and 13 radical cystectomy cases were also included. The postoperative defecation frequency and stool form were retrospectively evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients who underwent rectal mobilization, laparoscopy, and prior hysterectomy had more frequent defecation 8–14 days postoperatively than those who did not. Laparoscopy and rectal mobilization were plausible causes of increased defecation frequency after anterior pelvic exenteration. Anterior pelvic exenteration with rectal mobilization was associated with more frequent defecation than radical hysterectomy and radical cystectomy, and laparoscopic-anterior pelvic exenteration was associated with more frequent stools than laparoscopic- radical hysterectomy and laparoscopic-radical cystectomy. However, there was no difference in defecation frequency among laparotomic-anterior pelvic exenteration, laparotomic-radical hysterectomy, and laparotomic-radical cystectomy. Anterior pelvic exenteration with rectal mobilization and laparoscopic-anterior pelvic exenteration had higher Bristol Stool Form Scale scores than radical hysterectomy and laparoscopic-radical hysterectomy, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In anterior pelvic exenteration requiring the preservation of defecatory function, patients can experience postoperative frequent watery stools. Prospective studies are needed to validate these findings in larger cohorts.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144492973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}