Journal of Obstetrics and Gynaecology Research最新文献

{"title":"To improve outcome after ovarian tissue cryopreservation and transplantation: Clinical approach based on a case series and literature review","authors":"Hannah R. Rowling,&nbsp;Lucette A. J. van der Westerlaken,&nbsp;Eileen E. L. O. Lashley","doi":"10.1111/jog.70080","DOIUrl":"10.1111/jog.70080","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Ovarian tissue cryopreservation (OTC) is an acceptable fertility preservation technique in prepubertal girls and those unable to undergo ovarian stimulation for oocyte vitrification. Currently, there is limited data regarding the optimal fertility approach within this patient population. We aimed to determine a protocol for clinicians to help patients that underwent postpubertal OTC and return with the wish to conceive.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this study, we describe the management and outcome of 14 patients that underwent OTC and ovarian tissue transplantation (OTT) in our tertiary center and review the existing literature on management and outcome after OTC and OTT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our findings suggest pregnancy chances after OTT are highest in patients &lt;36 years of age, with normal ovarian reserve at the time of OTC, who have not received radiotherapy to the pelvic area. Chances of pregnancy after heterotopic transplantation are low. Assisted reproductive technology (ART) outcomes after OTT are lower than in the general population with subfertility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A passive ART approach is advised after OTT, except in patients with pre-existing fertility issues. For others, ART can be considered if pregnancy is not achieved within 10 months after ovarian function recovery. Repeated transplantation has limited efficacy and should be carefully considered, especially in those who did not regain ovarian function after first OTT.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.70080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Regional Cohort Study Examining Causes and Trends in Early Neonatal Death Over 20 Years in Miyazaki, Japan","authors":"Shoko Ohtomi,&nbsp;Yohei Maki,&nbsp;Emi Kino,&nbsp;Yuki Kodama,&nbsp;Shinji Katsuragi","doi":"10.1111/jog.70096","DOIUrl":"10.1111/jog.70096","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To determine the causes and trends of early neonatal death over 20 years using a regional database in the regional part of Japan.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this regional cohort study conducted in Miyazaki Prefecture, Japan, the causes of neonatal deaths were determined through a multidisciplinary regional audit and registered in a database. Data on early neonatal death, defined as neonate birth at ≥ 22 weeks gestational age and death within the first 7 days from birth, were extracted from the database between 2003 and 2022. The causes of early neonatal death were reclassified according to the International Classification of Diseases as perinatal mortality. The major categories were sub-classified into specific causes according to the International Classification of Disease-10. Trends in total early neonatal deaths and each cause were evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 186 583 live births and 124 early neonatal deaths occurred (0.66 per 1000 births). Among the 105 cases registered in the database, the most common category of early neonatal death was “congenital malformations, deformations, and chromosomal abnormalities” (48.6%), followed by “complications of intrapartum events” (12.4%), “infection” (9.5%), and “low birth weight and prematurity” (9.5%). Trisomy 18 was the most common cause (12.4%). The trends in the incidence of each cause of early neonatal death remained unchanged within the 20-year period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study revealed the common causes and trends of early neonatal death in a regional part of Japan. To reduce early neonatal death, a preventive strategy against early neonatal death due to common causes would be required in the future.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological, Immunohistochemical, and Biochemical Evaluation of the Effect of Berberine on Ovarian Hyperstimulation Syndrome in Rats","authors":"Filiz Yilmaz,&nbsp;Orkun Ilgen,&nbsp;Alper Mankan,&nbsp;Bayram Yilmaz,&nbsp;Ercan Ayaz,&nbsp;Sefa Kurt","doi":"10.1111/jog.70088","DOIUrl":"10.1111/jog.70088","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>OHSS is a potentially fatal condition. We aimed to investigate the effects of berberine administration on folliculogenesis and VEGF, TGF-α, IL-1β, and IL-6 levels in the OHSS model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A total of 28 female immature Wistar albino rats were divided into four groups: Sham group, Berberine group, OHSS group, and OHSS + Bb group. An OHSS model was created in which 10 IU PMSG was administered for four consecutive days and 30 IU hCG on Day 5. On Day 7, all subjects were sacrificed. Body weight, ovarian weight, histologic evaluation of ovaries, biochemical evaluation of TGF-α, IL-1β, and IL-6 expressions, and VEGF immunohistochemical analysis were performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Body weight, ovarian weight, follicular cell degeneration, vascular congestion, edema, and inflammation parameters were highest in the OHSS group (<i>p</i> &lt; 0.05). In the OHSS + Bb group, primary follicles and secondary follicles increased, while corpus luteum, atretic follicles, TGF-α, IL-1β, and IL-6 levels, and VEGF expressions decreased compared to the OHSS group (<i>p</i> &lt; 0.05). No statistical difference was observed between the control group and the OHSS + Bb group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In the present study, we demonstrated that berberine has the potential to prevent the development of OHSS in animal models. This finding suggests that further investigation into the use of berberine in human studies could provide valuable insights and inform the development of effective treatment strategies for OHSS. Consequently, the risk of OHSS can be reduced by administering berberine to patients undergoing the controlled ovarian hyperstimulation protocol. Therefore, the life risk of patients due to OHSS may be eliminated.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The initial report of prospective study for maternal and fetal outcomes to investigate the safety of multifetal pregnancy reduction in Japan","authors":"Nao Wakui,&nbsp;Masayuki Endo,&nbsp;Ayaka Shima,&nbsp;Aiko Okada,&nbsp;Tatsuya Miyake,&nbsp;Shoko Sugao,&nbsp;Kazuya Mimura,&nbsp;Tadashi Kimura,&nbsp;Michiko Kodama","doi":"10.1111/jog.70072","DOIUrl":"10.1111/jog.70072","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to establish the safety of multifetal pregnancy reduction (MFPR) and examine its complications, patient background, and psychological impact.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This single-center, single-arm, prospective intervention study included 10 women who were treated at our institution between April and December 2024. The indications were triplet or higher-order multiple pregnancies, as well as twin pregnancies with serious maternal complications. Procedures were performed between 11 and 13 gestational weeks, and the patients were observed for up to 1 week postoperatively. The primary outcome was the completion ratio at hospital discharge, whereas the secondary outcomes were the survival rate of non-targeted fetuses, the number of adverse events, and the psychological evaluation of the patients at 1 week postoperatively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 10 patients, one carried twins, seven carried triplets, and two carried quadruplets; half had received ovulation-induction treatment. The procedure completion rate at discharge was 100%, although one patient required reoperation. The survival rate of non-targeted fetuses was 89.5% (17/19), and adverse events included vaginal bleeding and complete miscarriage. Maternal state-anxiety scores decreased significantly postprocedure, whereas depression scores remained elevated both before and after the procedure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The completion rate of MFPR using echo-guided transabdominal potassium chloride infusion was high, ensuring short-term maternal safety. Although no serious adverse event other than one case of total miscarriage was observed, a long-term safety evaluation is warranted. Moreover, the emotional burden on patients is high before and after the procedure, necessitating the importance of long-term support.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Study on CO2 Laser for Second-Line Treatment of Vulvar Lichen Sclerosus","authors":"Gian Piero Siliquini,&nbsp;Margherita Giorgi,&nbsp;Concetta Strano,&nbsp;Francesca Accomasso,&nbsp;Beatrice Marina Pennati,&nbsp;Irene Fusco,&nbsp;Tiziano Zingoni,&nbsp;Fabrizio Bert,&nbsp;Valentina Elisabetta Bounous","doi":"10.1111/jog.70098","DOIUrl":"10.1111/jog.70098","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Vulvar Lichen Sclerosus (VLS) represents a persistent inflammatory disease of the skin that particularly affects the genital area.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The study purpose was to investigate the effectiveness of CO₂ laser as a treatment of recalcitrant VLS. The parameters examined included treatment tolerance, patient satisfaction, symptoms, and VLS clinical markers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study enrolled 85 adult women affected by Vulvar Lichen Sclerosus (VLS), refractory to local corticosteroids. Patients were treated with three sessions of fractional CO₂ laser treatment at 4-week intervals. For vulvovaginal treatment, a device with a scanning handpiece and dedicated probes was used. The effectiveness of the treatment was evaluated at 1 month follow up (T1) and at 6 months follow up (T2) from the last treatment session. The Vulvar Health Index (VuHI) and the Vaginal Health Index score (VHI) were used. Patients assessed the severity of their symptoms (dyspareunia and dryness specifically) using the Visual Analogue Scale (VAS), a 10-point scale going from 0 (no symptoms) to 10 (maximum symptoms).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>VuHI showed significant improvement after completion of treatment compared to baseline (<i>p</i> &lt; 0.001). VHI showed significant improvement after completion of treatment compared to baseline (<i>p</i> &lt; 0.001). There was clear improvement, compared to baseline values, in the VAS score for superficial dyspareunia and for vulvar dryness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Overall, the results of this study demonstrated that treatment of recalcitrant VLS with fractional CO₂ laser improved both clinical assessment and symptoms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning–Predictive Models for Survival in Uterine Cancer Patients With Type 2 Diabetes: A Territory-Wide Cohort Study","authors":"Claire Chenwen Zhong,&nbsp;Junjie Huang,&nbsp;Zehuan Yang,&nbsp;Zhaojun Li,&nbsp;Yu Jiang,&nbsp;Jinqiu Yuan,&nbsp;Xiaodan Huang,&nbsp;Xiaofang Liu,&nbsp;Queran Lin,&nbsp;Han Wang,&nbsp;Jonathan Poon,&nbsp;Qi Dou,&nbsp;Irene Xin Yin Wu,&nbsp;Martin C. S. Wong","doi":"10.1111/jog.70087","DOIUrl":"10.1111/jog.70087","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to develop predictive models and establish a risk scoring system to identify risk factors associated with survival in uterine cancer patients with type 2 diabetes (T2D) and estimate their survival probabilities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were collected from the Hong Kong Hospital Authority Data Collaboration Laboratory (HADCL) from 2000 to 2020. Cox proportional hazards regression, survival tree, LASSO Cox regression, boosting, and random survival forest (RSF) were utilized to develop predictive models for survival. Key risk factors were identified through Shapley Additive Explanations analysis, whereas the AutoScore-Survival package facilitated the development of a risk scoring system.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This cohort study included 2047 uterine cancer patients with T2D. The average survival time was 100.82 (standard deviation: 72.75) months. The RSF model demonstrated the strongest predictive performance, achieving a time-dependent area under the curve (AUC) of 0.823 and a <i>C</i>-index of 0.90. A risk scoring system was created based on several criteria: age at cancer diagnosis, duration of T2D, creatinine levels, serum potassium level, low-density lipoprotein cholesterol level (LDL-C) level, body mass index (BMI), and triglycerides level. This scoring system classified 31.4% of patients as high-risk, resulting in a 5-year survival probability of 43.5%, about 1.7 times lower than that of the low-risk group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study leveraged machine learning to identify key survival predictors and develop a clinically interpretable risk scoring system for uterine cancer patients with T2D. Key predictors, including age at cancer diagnosis, duration of T2D, creatinine levels, serum potassium levels, LDL-C levels, BMI, and triglycerides levels, effectively stratified survival risk. These findings demonstrate the potential of data-driven models to enhance individualized prediction and inform targeted clinical management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances and Challenges in Robotic-Assisted Gynecologic Surgery: A Comprehensive Review of Port Strategies, Surgical Platforms, and Learning Curves in Japan","authors":"Hiroaki Komatsu,&nbsp;Yuki Hiratsuka,&nbsp;Koji Yamamoto,&nbsp;Kohei Hikino,&nbsp;Masayo Okawa,&nbsp;Yuki Iida,&nbsp;Hiroki Nagata,&nbsp;Ai Ikebuchi,&nbsp;Mayumi Sawada,&nbsp;Shinya Sato,&nbsp;Fuminori Taniguchi","doi":"10.1111/jog.70089","DOIUrl":"https://doi.org/10.1111/jog.70089","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Robotic-assisted surgery has significantly advanced gynecologic surgery by improving precision, ergonomics, and patient outcomes. This review highlights recent developments and ongoing challenges in robotic gynecologic procedures, with a focus on port placement strategies, evolving surgical platforms, and learning curves. Particular emphasis is placed on Japan's growing experience, including novel techniques and training initiatives.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a literature review of English-language publications (2020–2025) focusing on robotic gynecologic surgery, particularly in Japan. Topics included surgical platforms (da Vinci, Hugo, hinotori), port configurations, clinical outcomes, and training. Selected studies were synthesized to reflect current evidence and expert consensus.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Advancements include innovative port strategies (e.g., diamond configuration) and expanded use of alternative robotic systems. New platforms like Hugo and hinotori show comparable outcomes to da Vinci, despite longer setup times during early adoption. Robotic surgery provides advantages in complex benign cases and gynecologic cancers, such as improved lymph node mapping and reduced morbidity. Surveys in Japan show strong support for robotics, though barriers like cost and uneven access remain. Learning curve data suggest surgical proficiency can be achieved after 10–30 cases. However, consensus on certification remains divided.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Robotic-assisted gynecologic surgery is advancing rapidly, supported by technical innovation and improved clinical outcomes. Japan plays a key role in refining techniques and evaluating new systems. Although training and cost challenges persist, continued investment in education and infrastructure is essential to broaden access and optimize patient care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to “Perioperative Outcomes in Patients With Very Low-Risk Endometrial Cancer Undergoing Surgery Without Lymph Node Dissection: Results From KGOG 2021”","authors":"Celal Akdemir","doi":"10.1111/jog.70090","DOIUrl":"https://doi.org/10.1111/jog.70090","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Insulin-Like Growth Factor Binding Protein-1 (Actim PROM Test) for Detection of Premature Rupture of Fetal Membranes","authors":"","doi":"10.1111/jog.70094","DOIUrl":"10.1111/jog.70094","url":null,"abstract":"<p>\u0000 <b>RETRACTION</b>: <span>I. A. Abdelazim</span>, “ <span>Insulin-Like Growth Factor Binding Protein-1 (Actim PROM Test) for Detection of Premature Rupture of Fetal Membranes</span>,” <i>Journal of Obstetrics and Gynaecology Research</i> <span>40</span>, no. <span>4</span> (<span>2014</span>): <span>961</span>–<span>967</span>, https://doi.org/10.1111/jog.12296.\u0000 </p><p>The above article, published online on 26 February 2014 in Wiley Online Library (wileyonlinelibrary.com), and the associated Expression of Concern (https://doi.org/10.1111/jog.16211) have been retracted by agreement between the journal Editor-in-Chief, Hiroaki Kajiyama; Japan Society of Obstetrics and Gynecology; and John Wiley &amp; Sons, Australia, Ltd. The retraction has been agreed upon following concerns raised by a third-party regarding inconsistencies in the reported data. The author stated that Group 1 in this paper was identical to Group 1 in their previous article. However, Table 1 of this article displaying the maternal and gestational age of the patients contains different data from that shown for the same group in the previous article. Furthermore, the author disclosed that the statistical analysis of the patient data had been outsourced to a statistical specialist, who provided only the results and significance levels. As a result, the author was unable to explain or verify the methodology used to calculate the p-values and Chi Square tests. The inconsistencies in participant data and absence of a clear explanation for the statistical procedures undermine confidence in the validity of the results. Therefore, the editors consider the results and conclusions reported in this article to be unreliable. The authors disagree with the retraction.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.70094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Placental Alpha Microglobulin-1 (AmniSure Test) Versus Insulin-Like Growth Factor Binding Protein-1 (Actim PROM Test) for Detection of Premature Rupture of Fetal Membranes","authors":"","doi":"10.1111/jog.70095","DOIUrl":"10.1111/jog.70095","url":null,"abstract":"<p>\u0000 <b>RETRACTION</b>: <span>I. A. Abdelazim</span> and <span>H. H. Makhlouf</span>, “ <span>Placental Alpha Microglobulin-1 (AmniSure Test) Versus Insulin-Like Growth Factor Binding Protein-1 (Actim PROM Test) for Detection of Premature Rupture of Fetal Membranes</span>,” <i>Journal of Obstetrics and Gynaecology Research</i> <span>39</span>, no. <span>6</span> (<span>2013</span>): <span>1129</span>–<span>1136</span>, https://doi.org/10.1111/jog.12045.\u0000 </p><p>The above article, published online on 30 May 2013 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement the journal Editor-in-Chief, Hiroaki Kajiyama; Japan Society of Obstetrics and Gynecology; and John Wiley &amp; Sons, Australia, Ltd. The retraction has been agreed upon following concerns raised by a third party regarding incorrect reporting of p-values. Following an investigation, the corresponding author disclosed that the statistical analysis of the patient data had been outsourced to a statistical specialist, who provided only the results and significance levels. As a result, the authors were unable to explain or verify the methodology used to calculate the p-values and Chi Square tests. The absence of a clear explanation for the statistical procedures undermines confidence in the validity of the results. Therefore, the editors consider the results and conclusions reported in this article to be unreliable. The authors disagree with the retraction.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.70095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}