Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Effects of Estriol-Lactobacilli Combination Versus Polycarbophil-Based Vaginal Moisturizer on Post-Radiation Vaginitis in Women With Cervical Cancer: A Randomized Controlled Trial","authors":"Natcha Koohachaiskun,&nbsp;Thiti Atjimakul,&nbsp;Krantarat Peeyananjarassri,&nbsp;Satit Klangsin,&nbsp;Kanet Kanjanapradit","doi":"10.1111/jog.70525","DOIUrl":"10.1111/jog.70525","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To compare the efficacy of an estriol-lactobacilli combination vaginal tablet (E3/L) and polycarbophil-based vaginal moisturizer (PBVM) in women with post-radiation vaginitis following cervical cancer treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This open-label, randomized controlled trial recruited 34 women with Stages I–III cervical cancer who had completed pelvic radiotherapy and developed vaginal toxicity symptoms. Participants were randomized 1:1 to E3/L (Gynoflor) or PBVM (Regelle) for 4 weeks. The primary outcome was change in vaginal maturation value (VMV). Secondary outcomes included changes in vaginal pH, vaginal toxicity symptom scores, and Female Sexual Function Index (FSFI) scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median improvement in VMV was significantly greater with E3/L than with PBVM (19.65 [IQR: 0–39.5] vs. 2.08 [IQR: 0–20.1] points; <i>p</i> = 0.035; 95% CI: 10.22–32.59). Vaginal dryness and inflammation improved significantly in the E3/L group. Changes in vaginal pH, dyspareunia, and vaginal pain were similar between groups. Although the FSFI change was greater with E3/L (median +6 vs. +2; <i>p</i> = 0.01), absolute FSFI scores at Week 4 were similar, and clinical significance is uncertain. Both treatments were well tolerated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In women with cervical cancer and radiation-induced vaginitis, E3/L showed greater short-term improvements in vaginal epithelial maturation, dryness, and inflammation than PBVM over 4 weeks. These findings are exploratory given the modest sample size, open-label design, and short follow-up; larger double-blind randomized trials with extended follow-up are needed to confirm these results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>Thai Clinical Trials Registry: TCTR2024051001</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 10","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Family Support and Loneliness at the First Consultation Among Women With Infertility","authors":"Satomi K. Doi,&nbsp;Aya Isumi,&nbsp;Mai Ohashi,&nbsp;Hiroyuki Fujiwara,&nbsp;Seung Chik Jwa","doi":"10.1111/jog.70519","DOIUrl":"10.1111/jog.70519","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>We examined the association between family support during fertility treatment and loneliness at the first clinical consultation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data from 204 women with infertility who first visited the Reproduction Center of a university hospital in Tochigi Prefecture between May 2024 and December 2025 and completed both a medical intake questionnaire and a web-based survey were analyzed. Family support from partners, own parents, and parents-in-law was assessed. Loneliness was measured using the three-item UCLA Loneliness Scale. Multivariable regression analyses were adjusted for sociodemographic, clinical, and psychosocial covariates, including adverse childhood experiences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among participants, 30.9% and 46.6% had not disclosed infertility treatment to their own parents and parents-in-law, respectively. Lower perceived support from parents-in-law and nondisclosure to parents-in-law were significantly associated with greater loneliness, whereas support from partners and own parents was not.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Disclosure to and support from parents-in-law may be particularly associated with lower level of loneliness at the initial consultation among women undergoing infertility treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 10","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Adoption of Minimally Invasive Surgery for Stage IA Endometrial Cancer: A Regional Multicenter Study in Japan","authors":"Kohshiro Nakao,&nbsp;Soichi Yamashita,&nbsp;Anri Azuma,&nbsp;Toshio Nishimura,&nbsp;Azusa Kobayashi,&nbsp;Tae Oike,&nbsp;Sadatomo Ikeda,&nbsp;Takashi Hirakawa,&nbsp;Ikuro Ito,&nbsp;Kazuto Nakamura,&nbsp;Akira Iwase","doi":"10.1111/jog.70528","DOIUrl":"10.1111/jog.70528","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The adoption of minimally invasive surgery (MIS) for endometrial cancer has progressed. This study aimed to evaluate the perioperative outcomes and early implementation of MIS in patients with preoperative International Federation of Gynecology and Obstetrics (FIGO) Stage IA endometrial cancer in a regional healthcare setting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective multicenter cohort study included consecutive patients who underwent surgery for presumed FIGO Stage IA endometrial cancer at three tertiary and cancer-specialized institutions in Gunma Prefecture, Japan, between 2018 and 2021. Patients were categorized into the MIS and open surgery groups according to the surgical approach. Perioperative outcomes, including operative time, estimated blood loss, hospital stay, blood transfusion, perioperative complications, and laboratory parameters, were compared between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This study included 365 patients, of whom 182 underwent MIS and 183 underwent open surgery. The proportion of MIS increased during the study period. Compared with open surgery, MIS was associated with significantly lower estimated blood loss (52 vs. 220 mL, <i>p</i> &lt; 0.001) and a shorter postoperative hospital stay (5 vs. 9 days, <i>p</i> &lt; 0.001), although operative time was longer (256 vs. 215 min, <i>p</i> &lt; 0.001). Postoperative complication rates were comparable, and severe complications were rare. Postoperative Day 1 C-reactive protein and creatine kinase levels were significantly lower in the MIS group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>MIS for preoperative FIGO Stage IA endometrial cancer was introduced across major institutions in a regional healthcare system. MIS was associated with favorable perioperative outcomes without increased complications, supporting the feasibility and perioperative safety of regional implementation of MIS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 10","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving Fetal Biometry in Fetal Intrahepatic Portosystemic Shunt With Late-Onset Preeclampsia and Focal Umbilical Cord Hypercoiling: A Case Report","authors":"Shiqi Liu,&nbsp;Xiaoya Shen,&nbsp;Ying Tang","doi":"10.1111/jog.70526","DOIUrl":"10.1111/jog.70526","url":null,"abstract":"<div>\u0000 \u0000 <p>Fetal intrahepatic portosystemic shunt may complicate fetal growth assessment, particularly when maternal and umbilical cord abnormalities coexist. We report a pregnancy first evaluated at our center at 26 + 3 weeks for suspected severe early-onset fetal growth restriction, with estimated fetal weight below the 1st percentile and abdominal circumference below the 3rd percentile. Prenatal ultrasound and fetal magnetic resonance imaging findings were consistent with fetal intrahepatic portosystemic shunt. Subsequent serial assessments showed improved fetal biometry. Routine umbilical artery and ductus venosus assessments were not clearly abnormal, whereas middle cerebral artery pulsatility index decreased in late gestation. A focal hypercoiled cord segment showed a higher umbilical artery systolic-to-diastolic ratio than routine sampling. Delivery at 35 + 2 weeks was indicated by severe preeclampsia and a positive oxytocin challenge test. The neonate was appropriate for gestational age, with postnatal ultrasound confirmation of persistent shunting and mild hyperammonemia.</p>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 10","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational Choriocarcinoma With Inferior Vena Cava Tumor Thrombus Formation","authors":"Qiong Yang,&nbsp;Ziyan Liang,&nbsp;Zhenhua Ming,&nbsp;Bing Wang,&nbsp;Rongkai Xie","doi":"10.1111/jog.70510","DOIUrl":"10.1111/jog.70510","url":null,"abstract":"<div>\u0000 \u0000 <p>Gestational choriocarcinoma with inferior vena cava (IVC) tumor thrombus formation is exceedingly rare. We report a case initially presenting with recurrent nausea and vomiting in a 52-year-old woman. Laboratory studies revealed elevated serum β-hCG levels, and ultrasonography demonstrated a pelvic mass extending from the parametrial area into the IVC. Pathological examination of a pelvic mass biopsy confirmed the diagnosis of choriocarcinoma. Further assessment identified pulmonary hypertension and emboli within small pulmonary artery branches. The patient received EMA-CO chemotherapy and achieved complete remission, with no evidence of recurrence during a one-year follow-up. This case highlights the diagnostic challenges posed by non-classical metastases and underscores the importance of considering choriocarcinoma in the differential diagnosis of women with a pregnancy history and unexplained systemic symptoms.</p>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 10","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and Validation of Biomarkers Associated With Mitochondrial Dynamics in Preeclampsia.","authors":"Xueying Liu, Mei Liu, Chuanyan Chen, Xiaoyan Gao, Zhenru Xu, Wenxiao Gao, Haining Qi, Qi Li, Jianhong Xing","doi":"10.1111/jog.70444","DOIUrl":"https://doi.org/10.1111/jog.70444","url":null,"abstract":"<p><strong>Aim: </strong>Despite studies highlighting mitochondrial dynamics in preeclampsia (PE), the regulatory mechanisms of mitochondrial dynamics-related genes (MD-RGs) in PE remain unclear. This study aims to explore these mechanisms.</p><p><strong>Methods: </strong>PE-related datasets (GSE10588 and GSE98224) and 23 MD-RGs were used. Differential expression, protein-protein interaction (PPI) network, machine learning (ML), gene expression, and receiver operating characteristic (ROC) analyses were conducted to screen for PE biomarkers. A nomogram was established to predict PE occurrence. Gene set enrichment analysis (GSEA) and immunoinfiltration analysis were subsequently performed.</p><p><strong>Results: </strong>Reverse transcription quantitative PCR (RT-qPCR) was used to measure biomarker expression, identifying GLUL, GPX3, and KCND2 as PE biomarkers. GPX3 and KCND2 were upregulated, whereas GLUL was downregulated in PE. These biomarkers had area under the curve (AUC) values of 0.7-0.9 in the datasets, and the integrated nomogram reached 0.973, indicating precision in PE prediction. GSEA revealed that ribosome and E. coli coenriched KCND2 and GLUL. Immunoinfiltration analysis revealed that Tregs were significantly correlated with KCND2 and GLUL among differential immune cells in PE patients versus controls. Finally, expression validation revealed that GLUL was significantly upregulated and expressed in the control group, whereas GPX3 and KCND2 were highly expressed in PE patients, with KCND2 reaching significant levels, which is consistent with the bioinformatics analysis.</p><p><strong>Conclusion: </strong>In total, 3 mitochondrial dynamics-related biomarkers (GLUL, GPX3, and KCND2) were identified, and the biomarker-based nomogram was used to predict the onset risk of PE patients. The mining of these biomarkers contributed to an in-depth understanding of the pathogenesis of MD-RGs in PE.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 10","pages":"e70444"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to \"Nigella sativa (Black Seed) Oil Alleviates the Serum Levels of IL-6 and Insulin in Patients With Polycystic Ovary Syndrome\".","authors":"Ronghua Jiang","doi":"10.1111/jog.70535","DOIUrl":"https://doi.org/10.1111/jog.70535","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 10","pages":"e70535"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Inflammatory Indices in Predicting Adverse Perinatal Outcomes in Pregnant Patients Undergoing Surgery for Acute Appendicitis: A Retrospective Cohort Study From a Tertiary Care Center.","authors":"Elif Isik, Zahid Agaoglu, Ciğdem Karagoz, Aydan Sezgin, Ayşe Altindis Bal, Dilek Sahin","doi":"10.1111/jog.70534","DOIUrl":"10.1111/jog.70534","url":null,"abstract":"<p><strong>Aim: </strong>The aim of this study was to investigate the predictive efficacy of inflammatory indices in predicting adverse perinatal outcomes in pregnant patients who underwent surgery for acute appendicitis.</p><p><strong>Methods: </strong>This single-center retrospective cohort study included 98 pregnant women who underwent appendectomy for acute appendicitis between December 2019 and December 2025 at a tertiary care hospital. Patients were classified according to the presence of composite adverse perinatal outcome (CAPO). The predictive value of preoperative inflammatory indices derived from routine complete blood count was evaluated using multivariable logistic regression and receiver operating characteristic (ROC) curve analyses.</p><p><strong>Results: </strong>In the CAPO+ group, gestational age at delivery, birth weight, and 1- and 5-min Apgar scores were significantly lower, whereas NICU admission rates were significantly higher (all p < 0.001). Among inflammatory indices, PIV, PLR, SII, and SIRI were significantly elevated, whereas LMR was significantly decreased (p < 0.001). Multivariate analysis identified LMR (OR: 0.32; 95% CI: 0.18-0.51) and SIRI (OR: 1.33; 95% CI: 1.16-1.56) as independent predictors of CAPO (p < 0.001). ROC analysis demonstrated that LMR achieved the highest predictive accuracy (AUC: 0.857; cut-off: ≤ 1.69; specificity: 93.4%).</p><p><strong>Conclusions: </strong>LMR and SIRI, calculated from routine complete blood count, emerged as independent predictors of CAPO with high predictive accuracy in pregnant patients with acute appendicitis and represent practical biomarkers that can be readily integrated into clinical decision-making without additional cost. Prospective, multicenter studies with larger sample sizes are needed to confirm the broader applicability of these findings.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 10","pages":"e70534"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early β-hCG Trajectories After Single-Dose Methotrexate Treatment and Their Predictive Value for Treatment Failure in Tubal Ectopic Pregnancy: A Retrospective Cohort Study.","authors":"Juanping Zhang, Yanni Ma","doi":"10.1111/jog.70532","DOIUrl":"https://doi.org/10.1111/jog.70532","url":null,"abstract":"<p><strong>Objective: </strong>To identify distinct early beta-human chorionic gonadotropin (β-hCG) trajectories following single-dose methotrexate (MTX) treatment for tubal ectopic pregnancy and to evaluate their associations with treatment outcomes and potential value for Day-7 posttreatment risk stratification.</p><p><strong>Methods: </strong>This retrospective cohort study included hemodynamically stable patients with confirmed tubal ectopic pregnancy treated with single-dose MTX. Among 828 patients in the all-clinical cohort, 373 had quantitative β-hCG measurements at Day 0, Day 4, and Day 7 and were included in trajectory modeling. Group-based trajectory modeling was applied to log-transformed β-hCG values. Multivariable logistic regression evaluated associations with overall treatment failure and clinical treatment failure, while exploratory Day-7 risk-stratification analyses assessed model discrimination, calibration, and net benefit.</p><p><strong>Results: </strong>Overall treatment failure occurred in 94 of 373 patients (25.2%), and clinical treatment failure occurred in 45 patients. A three-class quadratic model identified a rapid decline class (56.3%), delayed decline class (28.2%), and persistent elevation/slow decline class (15.5%). Compared with the rapid decline class, the persistent elevation/slow decline class was associated with higher odds of overall treatment failure (adjusted OR [aOR] = 85.42, 95% CI: 25.64-284.55) and clinical treatment failure (aOR = 52.65, 95% CI: 11.22-246.88), although estimates for clinical failure were imprecise. In the exploratory Day-7 model for overall treatment failure, the apparent AUC increased from 0.775 for the base clinical model to 0.862 after adding trajectory class (p < 0.001). Trajectory classes also showed heterogeneity in clinical failure within conventional Day 4-Day 7 β-hCG response categories.</p><p><strong>Conclusion: </strong>Early β-hCG trajectories were associated with treatment outcomes after single-dose MTX and may complement conventional Day-7 posttreatment reassessment. Their clinical utility requires prospective multicenter external validation before routine use.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 10","pages":"e70532"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic Versus Laparotomy for Cytoreductive Surgery in Advanced Ovarian Cancer: A Prospective Cohort Study Comparing Surgical Outcomes, Postoperative Complications, Quality of Life, and Survival.","authors":"Guiyan Yang, Jiali Yang, Yanli Chen","doi":"10.1111/jog.70516","DOIUrl":"https://doi.org/10.1111/jog.70516","url":null,"abstract":"<p><strong>Objective: </strong>To compare surgical outcomes, postoperative complications, quality of life, and survival between laparoscopic surgery and laparotomy for cytoreductive surgery in patients with advanced ovarian cancer.</p><p><strong>Methods: </strong>This cohort study included 60 patients with FIGO Stage III-IV advanced ovarian cancer, allocated to the control group or the study group. Quality of life was measured. Overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS) were analyzed.</p><p><strong>Results: </strong>Laparoscopic surgery significantly reduced operative time, blood loss, time to bowel recovery, and chemotherapy initiation. It also resulted in higher lymph node yield and optimal cytoreduction rate. Postoperative complication rates, including hypokalemia, hypoproteinemia, wound infection, and venous thrombosis, were significantly lower in the laparoscopic group. Quality of life improved significantly post-treatment in the laparoscopic group. Five-year OS rates were 75.0% vs. 51.9% (p = 0.055), DFS rates were 75.0% vs. 51.9% (p = 0.057), and PFS rates were 75.0% vs. 51.9% (p = 0.072) for laparoscopic and laparotomy groups, respectively. Kaplan-Meier analysis showed trends favoring the laparoscopic group, with OS approaching statistical significance.</p><p><strong>Conclusion: </strong>Laparoscopic cytoreductive surgery in advanced ovarian cancer improves perioperative outcomes, reduces complications, and enhances postoperative recovery while maintaining comparable long-term survival outcomes to laparotomy.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 10","pages":"e70516"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}