Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Pregnancy outcomes in women with different endometriosis lesion types: A review of current evidence","authors":"Hrishikesh Munshi,&nbsp;Nayna Barada,&nbsp;Sandhya Anand,&nbsp;Rahul K. Gajbhiye","doi":"10.1111/jog.16321","DOIUrl":"https://doi.org/10.1111/jog.16321","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Endometriosis, affecting ~10% of women of reproductive age, is associated with infertility and adverse pregnancy outcomes. The condition is classified into superficial peritoneal endometriosis (SUP), ovarian endometriomas (OMA), and deep infiltrating endometriosis (DIE), with varying impacts on pregnancy. This review examines the relationship between lesion subtypes and adverse maternal–fetal outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive literature search was conducted using PubMed, Scopus, Google Scholar, and Web of Science. Studies published between 2014 and 2025 that investigated pregnancy outcomes in women with endometriosis were included. Articles were screened based on predefined inclusion criteria, with 10 studies meeting the final selection. Outcomes analyzed included placenta previa, preterm birth, stillbirth, pre-eclampsia, intrauterine growth restriction (IUGR), and miscarriage.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Women with endometriosis exhibited a significantly higher risk of placenta previa, particularly those with Stages III–IV disease (<i>p</i> &lt; 0.05) and deep infiltrating lesions (<i>p</i> &lt; 0.05). The risk was further elevated in pregnancies conceived via assisted reproductive technologies (ART) (<i>p</i> = 0.01). The likelihood of preterm birth was higher in patients with bladder DIE (<i>p</i> = 0.02) and rectal DIE (<i>p</i> = 0.01), but not in those with ovarian endometriomas. Meta-analysis data indicated a moderate association between endometriosis and pre-eclampsia (<i>p</i> &lt; 0.05), particularly in patients with deep lesions (<i>p</i> = 0.03). Stillbirth risk showed inconsistent findings, with some studies reporting an increased risk (<i>p</i> &lt; 0.05) while others found no significant association. IUGR and small-for-gestational-age (SGA) infants were more common in women with DIE (<i>p</i> = 0.03) and advanced-stage disease (<i>p</i> = 0.05). Miscarriage risk was elevated in patients with superficial endometriosis (<i>p</i> &lt; 0.05) compared with those with DIE or OMA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Endometriosis, particularly ovarian and deep infiltrating, significantly increases the risk of placenta previa, preterm birth, IUGR, and miscarriage. ART conception further amplifies these risks. While conflicting evidence exists for stillbirth and pre-eclampsia, lesion-specific trends suggest a need for individualized obstetric management. Larger studies are required to clarify these associations and optimize pregnancy care for affected women.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of intraovarian versus subcutaneous corifollitropin alfa administration in DuoStim protocol for infertile women with low in vitro fertilization response","authors":"Fatemeh Keikha,&nbsp;Firoozeh Rakhshani Moghadam,&nbsp;Seyedeh Shahed Shoarishoar,&nbsp;Azadeh Tarafdari,&nbsp;Marjan Ghaemi","doi":"10.1111/jog.16316","DOIUrl":"https://doi.org/10.1111/jog.16316","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>Infertility in women, particularly those with a poor response to in vitro fertilization (IVF), poses significant challenges in reproductive medicine. This study aimed to compare the effectiveness of intraovarian versus subcutaneous injection of corifollitropin alfa in the DuoStim protocol among infertile women exhibiting a poor response to IVF, with a specific focus on oocyte retrieval counts and quality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A total of 40 poorly responding infertile women were randomly assigned to two groups: 20 women received corifollitropin alfa via intraovarian injection, and 20 women received it via subcutaneous injection. Key demographic data, cycle duration, gonadotropin dosage, the number of oocytes retrieved, and oocyte quality (specifically Grade B oocytes) were assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Demographic analyses revealed no significant differences between the two groups in terms of age (subcutaneous: 37.91 ± 6.11 years; intraovarian: 36.84 ± 5.42 years; <i>p</i> = 0.17) or weight (subcutaneous: 74.15 ± 10.51 kg; intraovarian: 78.24 ± 13.22 kg; <i>p</i> = 0.42). The number of oocytes retrieved during both phases did not significantly differ, but the intraovarian group yielded a notably higher number of Grade B oocytes during the follicular phase (<i>p</i> = 0.02). No significant differences were observed in cycle duration (<i>p</i> &gt; 0.05) or the final dose of gonadotropins administered (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study revealed that intraovarian injection of corifollitropin alfa may enhance the quality of oocytes retrieved, particularly Grade B oocytes, in women with poor response to IVF under the DuoStim protocol, while both methods exhibited similar outcomes in terms of demographic factors, cycle duration, and gonadotropin dosage.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External validation of a risk-scoring model for predicting adverse perinatal outcomes in pregnancies with fetal growth restriction","authors":"Jiratchaya Lekhalawan,&nbsp;Chitkasaem Suwanrath,&nbsp;Noppasin Khwankaew,&nbsp;Polathep Vichitkunakorn","doi":"10.1111/jog.16319","DOIUrl":"https://doi.org/10.1111/jog.16319","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to validate the Prince of Songkla University (PSU) risk-scoring model for predicting adverse perinatal outcomes in pregnancies with an antenatal diagnosis of fetal growth restriction (FGR) in an independent cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective study was conducted on 121 non-anomalous singleton pregnancies affected by FGR between July 2022 and April 2024. The predictive performance of the PSU risk-scoring model, which combines maternal factors and simple ultrasound measurements to predict adverse perinatal outcomes in FGR, was evaluated by applying the original model to this independent cohort. Model variables included a history of hypertensive disorders of pregnancy (HDP) (1 point), chronic hypertension (3 points), HDP (2 points), maternal weight gain &lt;8 kg (1 point), early-onset FGR (1 point), estimated fetal weight &lt; 5th percentile (2 points), amniotic fluid index &lt;5 cm (3 points), and abnormal umbilical artery Doppler (2 points). Predictive performance was evaluated using area under the receiver operating characteristic curve (AUC). Sensitivity and specificity were calculated at different cut-off values.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Median (interquartile range) gestational age at FGR diagnosis was 29 (22–39) weeks. Adverse perinatal outcomes occurred in 35 cases (28.9%). A cut-off score of 2 provided the highest sensitivity (85.7%) with a specificity of 51.2% for predicting adverse perinatal outcomes, with an AUC of 0.809 (95% confidence interval 0.714–0.905).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study confirms the predictive performance of the PSU risk-scoring model for adverse perinatal outcomes in FGR pregnancies, highlighting its potential to identify at-risk patients for referral, particularly in low-resource settings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between uric acid to high-density lipoprotein cholesterol ratio and the prevalence of female infertility","authors":"Jing Zhe,&nbsp;Dan Zheng","doi":"10.1111/jog.16309","DOIUrl":"https://doi.org/10.1111/jog.16309","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The relationship between uric acid to high-density lipoprotein (HDL) cholesterol ratio (UHR) and female infertility remains unclear. The aim of our study was to explore the correlation between UHR and fertility in US adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data from the National Health and Nutrition Examination Survey from 2013 to 2018 was analyzed in this study. UHR was considered the independent variable, and female infertility was the dependent variable. Multivariable logistic regression and smooth curve fitting were conducted to evaluate the correlation between UHR and infertility. Subgroup and sensitivity analyses were utilized to assess the stability of the findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>UHR in transform and female infertility proved to have a positive relationship in logistic regression models, and this relationship remained significant after adjusting for all possible confounding factors (odds ratio [OR] = 1.86, 95% confidence interval: 1.28–2.69, <i>p</i> = 0.001). When UHR was split into four quartile groups, individuals in Tertiles 2, 3, and 4 separately had a 1.84, 1.86, and 2.02 times greater incidence of female infertility than those in Tertile 1. A positive linear relationship between UHR and female infertility incidence was demonstrated using smooth curve fitting. The results of the subgroup analysis revealed consistent correlations and no difference in the UHR index and infertility subgroups (<i>p</i> for interaction tests  &gt;0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This national study identified the association between a higher prevalence of female infertility and an elevated UHR. The findings suggested that UHR levels could be useful in predicting the incidence of infertility. The management of UHR should be given more consideration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of oncological outcomes between radical hysterectomy and radiochemotherapy for International Federation of Gynecology and Obstetrics 2018 stage IIIC1 cervical adenocarcinoma: A retrospective multicenter cohort study","authors":"Zhenwei Gao,&nbsp;Zhaohong Yin,&nbsp;Lixin Sun,&nbsp;Hongwei Zhao,&nbsp;Chunlin Chen,&nbsp;Ping Liu","doi":"10.1111/jog.16307","DOIUrl":"https://doi.org/10.1111/jog.16307","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>To compare oncological outcomes of radical hysterectomy (RH) and radiochemotherapy (R-CT) for stage IIIC1 (FIGO 2018) cervical adenocarcinoma patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Based on the Chinese Cervical Cancer Clinical Diagnosis and Treatment Project Database, we retrospectively reviewed 236 cases of FIGO stage IIIC1 cervical adenocarcinoma diagnosed between 2005 and 2019. The 5-year overall survival (OS) and 5-year disease-free survival (DFS) rates were compared between the two treatment groups using multivariate Cox regression models and the log-rank test, both in the overall study population and after propensity score matching (PSM).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From 63 926 patients, we selected 236 cases, including 203 in the RH group and 33 in the R-CT group. In the overall study population, R-CT was associated with significantly worse 5-year OS (51.8% vs. 67.2%, <i>p</i> &lt; 0.05) and 5-year DFS (43.1% vs. 60.1%, <i>p</i> &lt; 0.05) compared to RH. Multivariate analysis revealed that R-CT was an independent risk factor for 5-year DFS (hazard ratio [HR] = 2.226, 95% confidence interval [CI] 1.141–4.343, <i>p</i> &lt; 0.05) but not for 5-year OS (HR = 1.834, 95% CI: 0.829–4.061, <i>p</i> &gt; 0.05) in FIGO stage IIIC1 cervical adenocarcinoma. After matching (<i>n</i> = 26 in R-CT group vs. 73 in RH group), the R-CT group showed significantly lower 5-year OS (50.3% vs. 77.4%, <i>p</i> &lt; 0.05) and DFS (38.2% vs. 65.0%, <i>p</i> &lt; 0.05) compared to the RH group. In the matched cohort, R-CT remained an independent risk factor for 5-year DFS (HR = 2.299, 95% CI: 1.113–4.750, <i>p</i> &lt; 0.05) but not for 5-year OS (HR = 1.926, 95% CI: 0.792–4.682, <i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Among patients with stage FIGO 2018 IIIC1 cervical cancer adenocarcinoma, R-CT was not associated with better oncological outcomes than RH. Radiotherapy should not be the only recommended treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ischemic placental disease as a risk factor for bronchopulmonary dysplasia in extremely preterm infants","authors":"Yu Ariyoshi,&nbsp;Takayuki Iriyama,&nbsp;Seisuke Sayama,&nbsp;Eri Suzuki-Ariyoshi,&nbsp;Eriko Yano,&nbsp;Haruka Matsui,&nbsp;Kensuke Suzuki,&nbsp;Ayako Hashimoto,&nbsp;Mari Ichinose,&nbsp;Masatake Toshimitsu,&nbsp;Takahiro Seyama,&nbsp;Kenbun Sone,&nbsp;Osamu Wada-Hiraike,&nbsp;Atsushi Ito,&nbsp;Yoshihiko Shitara,&nbsp;Keiichi Kumasawa,&nbsp;Akio Ishiguro,&nbsp;Satsuki Kakiuchi,&nbsp;Kohei Kashima,&nbsp;Yasushi Hirota,&nbsp;Naoto Takahashi,&nbsp;Yutaka Osuga","doi":"10.1111/jog.16315","DOIUrl":"https://doi.org/10.1111/jog.16315","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aims to investigate the association between placental insufficiency and complications in extremely preterm infants in the context of ischemic placental disease (IPD), including preeclampsia, small-for-gestational-age (SGA), and placental abruption.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Infants born between 22 and 28 weeks of gestation were classified into IPD and non-IPD groups, matched 1:1 by gestational age and sex. The incidence of neonatal complications was analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Analysis included 48 infants in each group. The IPD group had a significantly lower birth weight (IPD vs. non-IPD: 679 g vs. 979 g, <i>p</i> &lt; 0.001), whereas the non-IPD group was characterized by a higher prevalence of spontaneous preterm births (12% vs. 79%, <i>p</i> &lt; 0.001) and a significantly higher incidence of histological chorioamnionitis (CAM) (15% vs. 50%, <i>p</i> &lt; 0.001). The IPD group showed a significantly higher incidence of bronchopulmonary dysplasia (BPD) compared to the non-IPD group (85% vs. 48%, <i>p</i> &lt; 0.001), with no significant differences in other complications such as intraventricular hemorrhage, retinopathy of prematurity, and necrotizing enterocolitis. Logistic regression identified IPD as a significant risk factor for BPD (odds ratio [OR] [95% confidence interval]: 9.4 [2.8–31.8], <i>p</i> &lt; 0.001), along with preeclampsia (OR: 4.9 [1.3–18.3], <i>p</i> = 0.01) and SGA (OR: 31.9 [5.9–171], <i>p</i> &lt; 0.001). CAM was not associated with BPD (OR: 0.6 [0.2–1.7], <i>p</i> = 0.45).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Placental insufficiency, manifesting as IPD, is strongly associated with an increased risk of BPD in extremely preterm infants.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16315","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epicatechin prevents preeclampsia-associated hypertension and oxidative stress","authors":"Luis J Soto,&nbsp;Cecilia del Tufiño,&nbsp;Martha E Macias-Pérez,&nbsp;Seidy Castro-García,&nbsp;Estefanía Jiménez-Cruz,&nbsp;Rosa A Bobadilla-Lugo","doi":"10.1111/jog.16290","DOIUrl":"https://doi.org/10.1111/jog.16290","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Preeclampsia (PE) is a frequent and dangerous multisystemic pregnancy complication, associated with blood pressure control. Some antioxidants, including chocolate-derived epicatechin, can effectively attenuate hypertensive disorders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to assess whether epicatechin or dark chocolate (DC) could revert vascular increased reactivity and oxidative stress, both features of an experimental PE model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Rats from healthy pregnant or PE groups received vehicle, epicatechin (10 mg/kg/day) po, or DC (1 g) po, administered on days 1–14 (early) or days 7–21(late) of pregnancy. Blood pressure was measured by the tail-cuff plethysmography method. Aorta contractility was evaluated using a conventional isolated organ bath, and oxidative stress was determined by nicotine adenine dinucleotide phosphate reduced (NADPH) serum activity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Epicatechin and DC significantly reduced hypertension, decreased abdominal aorta contractility, and decreased NADPH activity of the PE animals. The effects were more evident when administered during the last 2 weeks of pregnancy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Results suggest that epicatechin has a significant antihypertensive effect in PE mediated by an antioxidant activity that improves vascular contractility.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of esketamine on perioperative anxiety and depressive symptoms in patients undergoing total hysterectomy","authors":"Jinfeng Ding,&nbsp;Yanqing Yang,&nbsp;Donghang Cao,&nbsp;Tingting Wang,&nbsp;Qimin Yu","doi":"10.1111/jog.16311","DOIUrl":"https://doi.org/10.1111/jog.16311","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to evaluate the effect of esketamine on perioperative anxiety and depressive symptoms, acute stress reaction, and serum neurotransmitters in patients undergoing total hysterectomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Clinical data of 120 patients undergoing total hysterectomy from May 2020 to June 2021 were retrospectively analyzed and divided into group C (3 mL of saline administered intravenously 10 min before surgical excision, 65 patients) or group K (0.5 mg/kg of esketamine administered intravenously 10 min before surgical excision, 55 patients).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Acute stress reaction, depression, and anxiety; and myeloperoxidase levels were lower while serum dopamine, 5-hydroxytryptamine, neuropeptide, as well as brain-derived neurotrophic factor levels were higher in group K than those in group C at 12 h postoperatively (<i>p</i> &lt; 0.05). Additionally, analgesic effect and postoperative fatigue at 3 h and 12 h postoperatively were lower in group K than those in group C (<i>p</i> &lt; 0.05). The incidence of adverse reactions in group K (14.55%) did not differ significantly from group C (4.62%) (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In summary, as a preventive measure for patients undergoing total hysterectomy, esketamine can reduce perioperative anxiety and depression, result in good analgesic and sedative effects without significantly increasing adverse effects.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143926094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From ethical or unethical to beneficial or non-beneficial: Shifting viewpoints on ChatGPT use in letter writing","authors":"Shigeki Matsubara","doi":"10.1111/jog.16317","DOIUrl":"https://doi.org/10.1111/jog.16317","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term relugolix use for rapidly growing uterine fibroids before uterus-preserving surgery in women seeking to conceive: Two case reports","authors":"Hiroshi Ishikawa,&nbsp;Erika Yao,&nbsp;Meika Kaneko,&nbsp;Masayuki Ota,&nbsp;Akiyo Takada,&nbsp;Kaori Koga","doi":"10.1111/jog.16312","DOIUrl":"https://doi.org/10.1111/jog.16312","url":null,"abstract":"<p>Large uterine fibroids that grow rapidly over a short period should be differentiated from uterine leiomyosarcoma, and their treatment remains controversial in women seeking to conceive. Here, we report two cases of uterine fibroids treated with short-term relugolix administration followed by myomectomy. Needle biopsy specimens obtained before relugolix administration showed no malignancy, and significant tumor shrinkage was observed following treatment. Both patients subsequently underwent myomectomy. One patient achieved a live birth 14 months after myomectomy, whereas the other experienced improvement in severe anemia, allowing her to prepare for pregnancy. Histological examination after relugolix administration revealed atrophic changes in spindle cells within the fibroids, characterized by nuclear crowding and decreased immunoreactivity for desmin and α-smooth muscle actin. The significant fibroid shrinkage observed after the short-term administration of relugolix provided a rationale for myomectomy, improved anemia, and facilitated appropriate uterine reconstruction, ensuring structural integrity for future pregnancies in women of reproductive age.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16312","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}