Journal of Obstetrics and Gynaecology Research最新文献

{"title":"A study on the factors influencing pregnancy-related anxiety and its correlation with family functioning and social support among primiparous pregnant women in early pregnancy","authors":"Jing Jin,&nbsp;Yinan Bao,&nbsp;Yingjie Han,&nbsp;Huixin Zhang,&nbsp;Qian Zheng,&nbsp;Xiaoling Zhao,&nbsp;Xiaoqing Xu,&nbsp;Dongyan Ji,&nbsp;Cuixiu Wang","doi":"10.1111/jog.16333","DOIUrl":"https://doi.org/10.1111/jog.16333","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The purpose of this study was to investigate the current status of pregnancy-related anxiety (PrA) in primiparous pregnant women, analyze the influencing factors of PrA, and its correlation with family function and social support.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a cross-sectional study that recruited 773 primiparous pregnant women from March to December 2019. The Pregnancy-related Anxiety Questionnaire was used to assess PrA, family function was measured by the Family Adaptation, Partnership, Growth, Affection, Resolve Scale, and social support was measured by the Perceived Social Support Scale.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The incidence of PrA among 773 primiparous pregnant women was 19.9%. Multiple logistic regression analysis showed that current physical discomfort, current working pressure, whether there were major changes in the family in the past half year, physical condition before this pregnancy, pregnancy intention, and family function were risk factors influencing PrA in primiparous pregnant women. PrA was negatively associated with family functioning (<i>p</i> &lt; 0.01). Family function was positively correlated with social support, family support dimension, and outside family support dimension (<i>p</i> &lt; 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>PrA was common among primiparous pregnant women in early pregnancy. Poor physical condition before and during pregnancy, major family accidents in the past half year, high work pressure during pregnancy, unexpected pregnancy, and family dysfunction were risk factors for PrA of primiparous pregnant women in early pregnancy. The PrA of primiparous pregnant women was negatively correlated with family function. Family function was positively correlated with social support, family support dimension, and outside family support dimension.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and prognostic values of serum insulin-like growth factor binding protein 4 expression in cervical cancer","authors":"Mingyang Wang,&nbsp;Zhiliang Wang,&nbsp;Xiaofeng Zou,&nbsp;Danhe Yang,&nbsp;Ke Xu","doi":"10.1111/jog.16313","DOIUrl":"https://doi.org/10.1111/jog.16313","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Insulin-like growth factor binding protein 4 (IGFBP4) is lowly expressed in cervical cancer (CC) cells. However, it remains unclear about its expression and diagnostic and prognostic values in CC. Therefore, this research probed the serum expression of IGFBP4 in CC patients and its diagnostic and prognostic values.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study prospectively included 146 CC patients admitted to our hospital (the CC group) from January 2018 to June 2020 and 146 patients with cervical intraepithelial neoplasia (CIN) admitted to the hospital (the CIN group) and 146 normal women receiving health checkups during the same period (the normal group). Serum IGFBP4 expression in CC patients was detected with quantitative reverse transcription-polymerase chain reaction. Receiver-operating characteristic (ROC) curves were utilized to evaluate whether serum IGFBP4 expression could assist in predicting CC occurrence. Kaplan–Meier survival analysis and Cox regression analysis were utilized to assess the significance of serum IGFBP4 expression in the prognosis of CC patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>IGFBP4 was downregulated in serum from CIN and CC patients, with lower expression in CC patients. Marked differences were noted in histologic differentiation, FIGO stage, and lymph node metastasis between the high and low IGFBP4 expression groups. The area under the ROC curve of serum IGFBP4 expression to assist in CC diagnosis was 0.9206 (cut-off, 0.8450; sensitivity, 86.30%; specificity, 81.51%). Low serum expression of IGFBP4 augmented the risk of poor prognosis in CC patients and was an independent risk factor for poor prognosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Low serum expression of IGFBP4 can assist in CC diagnosis and is an independent risk factor for the dismal prognosis of CC patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of uterine liposarcoma with PLAG1 rearrangement that was difficult to classify into established subtypes","authors":"Junka Koyama,&nbsp;Kota Washimi,&nbsp;Akihiko Yoshida,&nbsp;Hiroyuki Shigeta,&nbsp;Chie Murata,&nbsp;Hiroyuki Hayashi","doi":"10.1111/jog.16356","DOIUrl":"https://doi.org/10.1111/jog.16356","url":null,"abstract":"<p>Herein, we present a case of International Federation of Gynecology and Obstetrics stage IIIB (pT3bNxM0) uterine liposarcoma. Although intensive tumor resection was performed, the patient died 53 days after surgery. The resected surface of the tumor showed a yellowish hemorrhagic infarction. Histologically, adipocytes and lipoblasts were observed in the myxoid stroma. Immunohistochemical examination revealed that the tumor was diffusely positive for PLAG1 (pleomorphic adenoma gene 1) and focally positive for S100 protein and CDK10. The tumor was negative for smooth muscle actin, desmin, MDM2, CDK4, ER, ALK, STAT6, NKX2.2, SS18, DDIT3, BCOR, and pan-TRK. Fluorescence in situ hybridization showed that the tumor had a <i>PLAG1</i> gene rearrangement. However, further examination using RNA sequencing analysis failed to identify specific sequences. As the tumor was difficult to classify into the four subtypes of liposarcoma, the current disease might be a new type of uterine liposarcoma.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 7","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of dolutegravir on obstetrical outcomes among women living with HIV: A retrospective cohort study","authors":"Ammar Al Naimi,&nbsp;Charlotte Chang,&nbsp;Holly Rawizza,&nbsp;Oluwaseun Olaifa,&nbsp;Olabanjo Ogunsola,&nbsp;Prosper Okonkwo,&nbsp;Phyllis Kanki","doi":"10.1111/jog.16349","DOIUrl":"https://doi.org/10.1111/jog.16349","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To assess the effect of dolutegravir (DTG) on obstetrical outcomes for women living with HIV (WLWH).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study evaluated adult WLWH in antenatal care between 2016 and 2022 at two Nigerian centers. Patients were stratified into three antiretroviral therapy (ART) exposure groups: non-DTG ART, DTG-switch, and DTG. Multivariate linear and logistic regression models were utilized to assess the association between the type of ART and gestational weight gain (GWG), small for gestational age (SGA), gestational hypertension, and preterm birth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study included 1839 (77.1%) non-DTG users, 359 (15%) DTG users, and 188 (7.9%) DTG switchers. The adjusted association between DTG exposure and GWG was 0.72 (−0.08, 1.53) kg and 0.51 (−0.51, 1.54) kg for the DTG and DTG-switch groups, respectively, compared to other ARTs. The adjusted odds ratios for gestational hypertension were 0.47 (0.09, 2.49) and 1.31 (0.43, 4.02), 0.57 (0.22, 1.52) and 0.73 (0.25, 2.10) for preterm birth, and 0.55 (0.25, 1.20) and 0.26 (0.08, 0.83) for SGA in DTG and DTG-switch, respectively, compared to other ARTs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>DTG therapy is not associated with the risk of gestational hypertension nor preterm birth, and antenatal ART switching to DTG decreases the risk of growth restriction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16349","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative ongoing pregnancy and live birth rates after assisted reproduction among women with diminished ovarian reserve: A multi-institutional retrospective cohort study","authors":"Mio Kobayashi,&nbsp;Yoshimasa Asada,&nbsp;Yodo Sugishita,&nbsp;Satoko Osuka,&nbsp;Michio Kitajima,&nbsp;Kazuhiro Kawamura,&nbsp;Hiromitsu Shirasawa,&nbsp;Tomoko Tsuzuki,&nbsp;Mitsutoshi Yamada,&nbsp;Haipeng Huang,&nbsp;Seung Chik Jwa,&nbsp;Tatsuya Suzuki,&nbsp;Haruhiko Kanasaki,&nbsp;Keiji Kuroda,&nbsp;Masanori Ono,&nbsp;Yukiko Katagiri,&nbsp;Hiroki Noguchi,&nbsp;Atsushi Fukui,&nbsp;Osamu Wada-Hiraike,&nbsp;Kiyo Masaki,&nbsp;Yoshikazu Kitahara,&nbsp;Akira Iwase","doi":"10.1111/jog.16336","DOIUrl":"https://doi.org/10.1111/jog.16336","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To examine the cumulative ongoing pregnancy/live birth rate per patient by encompassing all embryo transfer (ET) cycles associated with a single oocyte retrieval cycle among women with diminished ovarian reserve (DOR), and to investigate whether serum anti-Müllerian hormone (AMH) levels can predict a live birth success.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This multi-institutional retrospective cohort study included infertile women with DOR (AMH &lt;1.1 ng/mL) who began their first cycle of in vitro fertilization and/or intracytoplasmic sperm injection between January and December 2021. Outcomes using the retrieved embryos were evaluated for up to four ET cycles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 606 patients, 113 did not undergo ET. A total of 605 ET cycles were analyzed. Clinical pregnancy and ongoing pregnancy/live birth rates per ET cycle were significantly dependent on age, not AMH levels. Ongoing pregnancy/live birth rates per patient increased significantly with higher AMH levels. A significant difference in the cumulative ongoing pregnancy/live birth rate was observed depending on whether cases with no remaining embryos were included among the censored cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Assisted reproductive technology (ART) outcomes per ET cycle in women with DOR were similar to those reported in the Japanese ART registry without distinguishing DOR. The greater the number of good-quality embryos that can be frozen, the higher the expected cumulative live birth rate.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of intrahepatic cholestasis of pregnancy with preterm birth and low birth weight in offspring: A prospective cohort and Mendelian randomization study","authors":"Jiapeng Tang,&nbsp;Mengting Sun,&nbsp;Manjun Luo,&nbsp;Ye Chen,&nbsp;Yige Chen,&nbsp;Jianhui Wei,&nbsp;Xiaorui Ruan,&nbsp;Tingting Wang,&nbsp;Jiabi Qin","doi":"10.1111/jog.16348","DOIUrl":"https://doi.org/10.1111/jog.16348","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Intrahepatic cholestasis of pregnancy (ICP) is a common complication of pregnancy, which may lead to an increased risk of adverse pregnancy outcomes. This study aimed to use two different methods to explore the association of ICP with preterm birth (PTB) and low birth weight (LBW) in offspring.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>First, a large early pregnancy cohort with a sample size of 34 104 was used to explore the association of ICP with PTB and LBW by using logistic regression analysis. Second, using a two-sample Mendelian randomization, we further assessed the effect of ICP on PTB and birth weight based on 15 single nucleotide polymorphisms from a genome-wide association study of ICP (<i>n</i> = 210 870).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results of the cohort study show that maternal ICP was associated with an increased risk of both PTB (aOR = 1.760, 95% CI: 1.443, 2.146, <i>p</i> &lt; 0.001) and LBW (aOR = 2.220, 95% CI: 1.797, 2.741, <i>p</i> &lt; 0.001) after adjusting for potential confounders. Mendelian randomization analyses suggested a potential causal effect of ICP on the risk of PTB (OR = 1.037, 95% CI: 1.011, 1.063, <i>p</i> = 0.005) and that ICP significantly reduced birth weight (beta = −0.010, 95% CI: −0.016, −0.004, <i>p</i> = 0.002).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings suggest that ICP increases the risk of PTB and LBW, providing further evidence of these associations and highlighting the need for increased clinical monitoring of pregnant women with ICP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can vaginal natural orifice transluminal endoscopic surgery hysterectomy be performed in patients with an enlarged uterus?","authors":"Kemal Güngördük,&nbsp;Varol Gülseren,&nbsp;Berican Şahin Uyar,&nbsp;Özgün Akbaş,&nbsp;Serkan Üstüntaş,&nbsp;Emre Biton,&nbsp;İsa Aykut Özdemir","doi":"10.1111/jog.16345","DOIUrl":"https://doi.org/10.1111/jog.16345","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>In this study, the application of vaginal natural orifice transluminal endoscopic surgery (vNOTES) and conventional laparoscopy (CLS) underwent hysterectomy in patients with enlarged uterus was compared.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This multicenter study enrolled patients with an enlarged uterus (≥300 g) who underwent minimally invasive hysterectomy using either CLS or vNOTES in the Department of Obstetrics and Gynecology between January 2020 and December 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the enrolled patients with an enlarged uterus, 39 (65.0%) underwent conventional laparoscopy, and 21 (35.0%) underwent vNOTES. The median operative times were 80 (50–140) min in the conventional laparoscopy group and 70 (60–130) min in the vNOTES group (<i>p</i> = 0.008). Median blood loss was significantly lower in the vNOTES group (140 [80–210] vs. 160 [90–370] mL; <i>p</i> = 0.013). The length of hospital stay was comparable between groups. Intraoperative bladder injury occurred in one patient in each group—conventional laparoscopy (2.6%) and vNOTES (4.8%) (<i>p</i> = 0.651). Conversion to laparotomy was required in three patients (7.7%) in the CLS group and one patient (4.8%) in the vNOTES group (<i>p</i> = 0.664). The visual analog scale pain score was significantly lower in the vNOTES group at 6, 12, and 24 h postoperatively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>vNOTES was confirmed to be a safe, feasible, and effective approach for hysterectomy in patients with an enlarged uterus.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophils and other blood cell traits in the risk of infertility population: A Mendelian randomization analysis","authors":"Shiqi Yi,&nbsp;Ying Feng,&nbsp;Yuping Zhang,&nbsp;Linyu Zhang,&nbsp;Xinrui Sun,&nbsp;Yi Zhang,&nbsp;Qianhong Ma,&nbsp;Fang Ma","doi":"10.1111/jog.16347","DOIUrl":"https://doi.org/10.1111/jog.16347","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Abnormalities in blood cell parameters, including eosinophil traits, have been implicated in reproductive system damage. However, their specific relationship with infertility and abnormal spermatozoa remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>In this study, we investigated 23 blood cell parameters, including eosinophil traits, using bidirectional Mendelian randomization analysis to explore their causal relationship with male and female infertility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We utilized data from the INTERVAL study, UK Biobank, Blood Cell Consortium, and GWAS Catalog for 23 blood cell parameters, as well as GWAS data from the FinnGen database for two infertile populations and one clinical phenotype related to infertility. MR analysis was conducted employing various methods, including inverse-variance weighting (IVW), to obtain statistically significant results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the blood cell parameters examined, three were associated with the risk of male infertility: eosinophil percentage of granulocytes, eosinophil cell count, and mean sphered cell volume. Among these, eosinophil levels exhibited the most significant correlation with male infertility. In contrast, no blood cell traits were identified as risk factors for female infertility. However, basophil cell count and hemoglobin concentration-related traits appeared to serve as protective factors for female infertility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Abnormal eosinophil levels may increase the risk of male infertility. However, given the limitations inherent in the observational design of this MR study, further research is required to assess the potential therapeutic effects of eosinophil reduction in idiopathic male infertility. Regarding female infertility, the study suggests that certain blood cell traits, such as basophil cell count, may act as protective factors, which warrants further investigation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent cisplatin chemotherapy with intensity-modulated radiotherapy followed by consolidation chemotherapy in early-stage cervical cancer patients with high-risk factors after radical hysterectomy","authors":"Si-Tong Wang,&nbsp;Gui-Fen Ma,&nbsp;Chun-Li Xiao,&nbsp;Ting-Yan Shi,&nbsp;Li-Bing Xiang,&nbsp;Li Ma,&nbsp;Gen-Lai Lin","doi":"10.1111/jog.16346","DOIUrl":"https://doi.org/10.1111/jog.16346","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the efficacy and toxicity of consolidation chemotherapy (C-CT) following concurrent cisplatin chemotherapy combined with intensity-modulated radiotherapy (IMRT) in patients with early-stage cervical cancer who present high-risk factors (HRFs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Between 2013 and 2023, a total of 190 women were included in this retrospective study. Among these, 82 patients received postoperative concurrent chemoradiotherapy (CCRT) with weekly cisplatin and IMRT (45.0–50.4 Gy), followed by C-CT, while 108 patients received CCRT alone. A propensity score matching (PSM) was performed with a ratio of 1:1. Clinical parameters, overall survival (OS), and relapse-free survival (RFS) were analyzed for both groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median follow-up duration was 50.2 months. The 4-year OS rates were 88.7% in the C-CT group and 87.9% in the CCRT-only group (<i>p</i> = 0.886). The 4-year RFS rates were 76.3% for the C-CT group and 80.5% for the CCRT-only group (<i>p</i> = 0.289). In patients with three or more positive lymph nodes, C-CT was associated with significantly improved OS compared to the CCRT-only group (HR 0.14, 95% CI 0.02–0.88, <i>p</i> = 0.036), while RFS showed no significant difference (HR 0.80, 95% CI 0.27–2.32, <i>p</i> = 0.676). However, the incidence of grade 3/4 hematologic toxicity was higher in the C-CT group (16.8% vs. 1.7%, <i>p</i> = 0.009).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study found that C-CT following concurrent cisplatin chemotherapy with IMRT did not confer additional benefits over CCRT alone in the majority of early-stage cervical cancer patients with HRFs, except in those with three or more positive lymph nodes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive score using umbilical vein leucine-rich α-2 glycoprotein as a useful biomarker for diagnosing histological chorioamnionitis in preterm infants","authors":"Genichiro Sotodate,&nbsp;Satoshi Serada,&nbsp;Mitsumasa Osakabe,&nbsp;Fumiaki Takahashi,&nbsp;Atsushi Matsumoto,&nbsp;Yukiko Toya,&nbsp;Shigekuni Tsuchiya,&nbsp;Minoru Fujimoto,&nbsp;Tetsuji Naka,&nbsp;Manami Akasaka","doi":"10.1111/jog.16344","DOIUrl":"https://doi.org/10.1111/jog.16344","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>We investigated the value of leucine-rich α-2 glycoprotein (LRG) in cord blood for diagnosing histological chorioamnionitis (HCAM) in preterm infants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective cohort study included 68 infants, born between 22 and 31 weeks of gestation, comprising 29 infants without and 39 infants with HCAM. Maternal, infant, and cord blood inflammatory markers were compared between the groups, and expression levels were compared using immunohistopathological staining of placental tissue.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The umbilical vein leucine-rich α-2 glycoprotein (UV-LRG) and gestational age were independent risk factors for HCAM (odds ratio [OR] 2.395, 95% confidence interval [CI] 1.230–4.663, OR 0.678, 95% CI 0.492–0.934, respectively). The predictive score was calculated as follows: 9.575 + (−0.386) × gestational age + 0.756 × UV-LRG. The predictive score (area under the curve 0.802, 95% CI [0.696–0.958]) appeared to be a reliable diagnostic model for HCAM and outperformed other inflammatory markers. At a cut-off value of 0.852, the predictive score showed a sensitivity of 57.1% and specificity of 93.1% for diagnosing HCAM. Immunohistopathological evaluation of the placenta revealed stronger LRG expression in the trophoblasts (TBs) and stroma in the group with HCAM than in the group without UV-LRG levels correlated positively with the immunohistopathological LRG intensity in the TBs and stroma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The predictive score using UV-LRG is a more useful biomarker than the other inflammatory markers for HCAM diagnosis. Investigating the mechanism by which TBs produce LRG and by which LRG migrates from the TBs to the stroma may help elucidate HCAM pathogenesis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}