Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Preoperative Prediction of the Risk of Intraoperative Hypothermia in Patients Undergoing Gynecological Laparoscopic Surgery: A Retrospective Cohort Study","authors":"Li Huang,&nbsp;Bo Liu,&nbsp;Dechao Lai,&nbsp;Liansheng Xu","doi":"10.1111/jog.70513","DOIUrl":"10.1111/jog.70513","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Intraoperative hypothermia (IOH) is a common complication in patients undergoing gynecological laparoscopic surgery that could benefit from early accurate identification of high-risk individuals. We developed a prediction model to predict IOH using only routine preoperative variables.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study utilized a retrospective cohort dataset from a single center, including patients undergoing gynecological laparoscopic surgery. Candidate predictors were extracted from electronic health records (EHRs) and anesthesia records. Stepwise logistic regression based on the Akaike information criterion (AIC) was applied for feature selection. A multivariable logistic regression model was developed and evaluated using an internal train-test split of the same single-center dataset. A nomogram was constructed to visualize the prediction model. Model performance was assessed using the area under the curve (AUC), calibration curve, Hosmer–Lemeshow test, and decision curve analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 1092 patients were included in this study, of which 433 cases (39.7%) were diagnosed with IOH. After feature selection using stepwise logistic regression, the model retained six key predictors: age, fasting duration, basal temperature, emergency surgery, estimated duration of surgery, and anesthesia induction time. The multivariable logistic regression model achieved an AUC of 0.7731 in the training set and 0.7475 in the test set. The Hosmer–Lemeshow test indicated good calibration (<i>χ</i>² = 3.8795, df = 8, <i>p</i> = 0.8678).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The logistic regression model performed well in predicting the risk of IOH in patients undergoing gynecological laparoscopic surgery. A nomogram was developed to provide an intuitive tool for preoperative risk screening.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 10","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age at Natural Menopause and Associated Lifestyle and Reproductive Factors Among Postmenopausal Women in Northwest Iran: A Cross-Sectional Study","authors":"Alireza Gholampour-Nooran,&nbsp;Mahnaz Azari,&nbsp;Afrouz Mardi,&nbsp;Fatemeh Abdoli","doi":"10.1111/jog.70507","DOIUrl":"10.1111/jog.70507","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Natural menopause marks the end of a woman's reproductive lifespan and has important implications for long-term health. The timing of natural menopause is associated with several health outcomes and is influenced by reproductive, anthropometric, and lifestyle factors. This study investigated age at natural menopause (ANM) and its associated lifestyle and reproductive determinants among postmenopausal women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study was conducted between March and December 2024 among 400 eligible postmenopausal women attending health centers affiliated with Ardabil University of Medical Sciences. Participants were selected using cluster random sampling. Data were collected using a demographic and reproductive characteristics questionnaire and the Lifestyle Questionnaire (LSQ). Statistical analyses included descriptive statistics, independent <i>t</i>-test, ANOVA, Pearson's correlation, and multivariable regression using SPSS version 21.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean ANM was 49.98 ± 2.62 years. Most participants were housewives (78%) and had low economic status (76%). Significant associations were found between menopause age and BMI (<i>p</i> = 0.001), number of abortions (<i>p</i> = 0.043), breastfeeding duration (<i>p</i> = 0.006), gravidity (<i>p</i> = 0.030), and contraceptive use (<i>p</i> = 0.050). Lifestyle score showed a positive correlation with menopause age (<i>p</i> = 0.001). Multivariable regression identified BMI and lifestyle dimensions, including weight control and nutrition, psychological, spiritual, social, environmental health, and accident prevention, as significant predictors of ANM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Natural menopause age was associated with reproductive characteristics, BMI, and lifestyle factors. Promoting healthy lifestyle behaviors may support healthy reproductive aging. However, prospective longitudinal studies are required to confirm these findings and clarify underlying mechanisms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 10","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological Findings in Tubal Sterilization Specimens: A Single-Center Cohort Study","authors":"Tuğba Gül Yılmaz,&nbsp;Addule Serhanoğlu Seçen,&nbsp;Saliha Sağnıç","doi":"10.1111/jog.70511","DOIUrl":"10.1111/jog.70511","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the histopathological spectrum of fallopian tube specimens obtained after tubal sterilization and to investigate its association with sterilization timing, surgical technique, and patient characteristics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study reviewed the medical records of women who underwent tubal sterilization between January 2023 and August 2025 at a tertiary referral center. Procedures were classified by timing (peripartum, interval, opportunistic) and surgical technique. Histopathological findings were categorized as normal, vascular congestion, cystic changes, inflammatory alterations, structural or obstructive changes, or specific lesions. Associations between histopathological findings and age, gravida, parity, sterilization timing, and surgical technique were analyzed using appropriate statistical methods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 944 women were included (median age: 35 years; range: 22–49). Most procedures were peripartum (83.2%), followed by interval (16.6%) and opportunistic (0.2%). Normal histology was the most common finding (62.1%), followed by vascular congestion (21.5%), cystic changes (11.1%), inflammation (3.3%), and specific lesions (1.3%). Histopathological findings differed significantly according to sterilization timing and surgical technique (<i>p</i> &lt; 0.001). Normal histology predominated in peripartum sterilizations performed during cesarean delivery, whereas abnormal findings were more frequent in interval and opportunistic procedures. Increasing age was associated with specific histopathological categories (<i>p</i> = 0.003), while no significant associations were observed with gravida or parity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Histopathological findings in tubal sterilization specimens were associated with sterilization timing and patient age, while no significant associations were observed with gravida or parity. These results underscore the importance of interpreting tubal pathology within the appropriate clinical context and provide large-scale data addressing an existing gap in the literature.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 10","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Discordant Monochorionic Dizygotic Twins After Double Blastocyst Transfer: Blood Chimerism Demonstrated by Multimodal Genetic Testing","authors":"Kotaro Yuki,&nbsp;Yumiko Taura,&nbsp;Hiroki Morishita,&nbsp;Takako Sugiura,&nbsp;Saki Kido,&nbsp;Yu Nakashima,&nbsp;Vlad Tocan,&nbsp;Yoshihito Inoue,&nbsp;Kiyoko Kato","doi":"10.1111/jog.70512","DOIUrl":"10.1111/jog.70512","url":null,"abstract":"<p>A 38-year-old woman conceived after intracytoplasmic sperm injection and frozen–thawed double blastocyst transfer. First-trimester ultrasonography suggested monochorionic diamniotic twins, but discordant external genitalia were identified at 21 weeks of gestation. Delivery at 37 weeks resulted in phenotypically normal female and male infants. Placental histopathology confirmed monochorionic diamniotic placentation. Postnatal multimodal genetic evaluation, including G-banding, single nucleotide polymorphism array, and buccal cell X/Y fluorescence in situ hybridization, demonstrated mixed 46,XX/46,XY cell lines in peripheral blood, consistent with predominantly blood-limited chimerism. Single nucleotide polymorphism array analysis demonstrated admixture of two independently derived genomes and findings inconsistent with a primary dispermic mechanism. These results supported a diagnosis of monochorionic dizygotic twinning with predominantly blood chimerism, most likely reflecting intertwin cell exchange. This case highlights the value of integrating tissue-specific genetic findings with postnatal phenotypic and clinical assessment to interpret predominantly blood-limited chimerism in MCDZ twins.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 10","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastasis of Invasive Ductal Carcinoma of the Breast to the Uterine Cervix 30 Years Post-Mastectomy: A Case Report","authors":"Taro Miyake,&nbsp;Hidenori Sasa,&nbsp;Tsubasa Ito,&nbsp;Takanori Watanabe,&nbsp;Takako Sato,&nbsp;Sho Ogata,&nbsp;Masashi Takano","doi":"10.1111/jog.70509","DOIUrl":"10.1111/jog.70509","url":null,"abstract":"<p>Metastasis of invasive ductal carcinoma of the breast to the uterine cervix is rare, with only one report of a case occurring more than 20 years after the primary surgery. A 69-year-old woman presented with abnormal uterine cervical cytology (atypical glandular cells without tumor diathesis) 30 years after undergoing breast cancer surgery. Magnetic resonance imaging revealed a 38-mm cervical mass. Modified radical hysterectomy was performed. The resected specimen exhibited an immunohistochemical profile of GATA3(+)/mammaglobin(+)/PAX8(−), which definitively excluded primary cervical adenocarcinoma and confirmed the diagnosis of metastatic invasive ductal carcinoma. Crucially, although the primary tumor was hormone receptor-positive, cervical metastasis exhibited receptor conversion to HER2-positive status. This case underscores the importance of considering metastatic breast cancer in the differential diagnosis of cervical masses in breast cancer survivors regardless of the disease-free interval. This further highlights the necessity for receptor re-evaluation in metastatic lesions to guide appropriate targeted therapy.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 10","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additive and Dose-Dependent Effects of Coenzyme Q10 Combined With Myoinositol on Insulin Resistance and Hyperandrogenism in Women With Polycystic Ovary Syndrome: A Retrospective Controlled Study","authors":"Burcu Dincgez,&nbsp;Gulten Ozgen,&nbsp;Nergis Kender Erturk,&nbsp;Hazel Cagın Kuzey,&nbsp;Esra Kartal Golcuk","doi":"10.1111/jog.70502","DOIUrl":"10.1111/jog.70502","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Polycystic ovary syndrome (PCOS) is characterized by insulin resistance, hyperandrogenism, and reproductive dysfunction. Myoinositol and coenzyme Q10 (CoQ10) have complementary metabolic and hormonal effects; however, the additive and dose-dependent effects of CoQ10 remain unclear. This study evaluated these effects in women with PCOS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this retrospective study, 200 women with PCOS were assigned to four groups: myoinositol plus CoQ10 100 mg (<i>n</i> = 55), myoinositol plus CoQ10 200 mg (<i>n</i> = 55), myoinositol alone (<i>n</i> = 45), and untreated controls (<i>n</i> = 45). Fasting insulin, HOMA-IR, total testosterone, and menstrual cycle regularity were assessed at baseline and 6 months. Between-group differences were evaluated using multivariable regression analyses and sensitivity analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All treatment groups showed improvements in metabolic and hormonal parameters, with the greatest effects observed in the combination therapy groups. Myoinositol alone was associated with significant reductions in HOMA-IR (<i>β</i> = −0.219; <i>p</i> &lt; 0.001) and total testosterone (<i>β</i> = −3.145; <i>p</i> &lt; 0.001) compared with untreated controls. The addition of CoQ10 resulted in dose-dependent improvements, with 100 and 200 mg doses demonstrating progressively greater reductions in HOMA-IR (<i>β</i> = −0.308 and −0.571, respectively) and total testosterone (<i>β</i> = −2.847 and −5.325, respectively) (all <i>p</i> &lt; 0.001). Multivariable regression analyses confirmed that both CoQ10 doses remained significantly superior to myoinositol monotherapy. Menstrual cycle regularity improved most in the MI + CoQ10 200 mg group (36.4%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Adjunctive CoQ10 supplementation with myoinositol provides significant and dose-dependent improvements in insulin resistance and hyperandrogenism in PCOS. The magnitude of reduction observed with 200 mg CoQ10 suggests potential clinical relevance, particularly in metabolically compromised patients. Prospective randomized studies are warranted to confirm these findings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 10","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Inequities in the Obstetrics and Gynecology Workforce: A Narrative Review","authors":"Tuangsit Wataganara,&nbsp;Eiko Yamamoto,&nbsp;Somsook Santibenchakul,&nbsp;Ninlapa Pruksanusak,&nbsp;Jitti Hanprasertpong,&nbsp;Suthee Panichkul,&nbsp;Supitchaya Surasereewong","doi":"10.1111/jog.70514","DOIUrl":"10.1111/jog.70514","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Obstetricians and gynecologists (OBGYNs) are high-risk, surgically intensive, and emergency-driven specialists. Women are the majority of OBGYNs, but their representation in decision-making roles remains disproportionately low. This narrative review explores the empirical evidence and aims to narrow gender gaps among OBGYNs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We included 154 publications from 2000 to 2025 on gender inequity, career progression, women physicians, OBGYNs, academic promotion, leadership, workforce, and regional variation from Asia, Europe, North America, Africa, South America, and the Caribbean. Eligible studies either (1) focused on OBGYNs or female surgeons, (2) reported gender disparities in academic, administrative, or service domains, or (3) provided regional data. Qualitative and quantitative studies, policy reports, and professional society publications were included.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were insufficient data from South America and the Caribbean. For the other regions, we identified cultures, societal norms, and the structures of health systems as contributors to gender barriers in OBGYNs. These barriers are not at the entry levels, but rather in career ascension. In high-income countries, implicit biases persist despite established work-life policies and legislative protections. In low and middle-income countries, disparities are shaped by sociocultural expectations, fewer institutional supports, and rigid hierarchical structures. Men also face distinct barriers, such as limited patient acceptance and unequal distribution of out-of-hours duties.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>There is an urgent need to acquire high-quality data on stereotypic biases, structural, and cultural barriers to gender inequities among OBGYNs. Without timely intervention, gender gaps within the OBGYN workforce will likely be widened over time.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 10","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PD-L1 Expression in Uterine Mesenchymal Tumors: A Comparative Immunohistochemical Analysis","authors":"Fajrin Mammadova Bahitli,&nbsp;Levent Akman,&nbsp;Gurdeniz Serin,&nbsp;Mert Acar,&nbsp;Nuri Yildirim,&nbsp;Osman Zekioglu,&nbsp;Mustafa Cosan Terek,&nbsp;Erdem Goker,&nbsp;Ahmet Aydin Ozsaran","doi":"10.1111/jog.70508","DOIUrl":"https://doi.org/10.1111/jog.70508","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate and compare programmed cell death-ligand 1 (PD-L1) expression across benign and malignant uterine mesenchymal tumors using immunohistochemical analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included 100 patients who underwent hysterectomy for uterine mesenchymal tumors at a single tertiary center between 2000 and 2022. Cases included leiomyoma (LM; <i>n</i> = 20), leiomyosarcoma (LMS; <i>n</i> = 20), low-grade endometrial stromal sarcoma (LG-ESS; <i>n</i> = 20), high-grade endometrial stromal sarcoma (HG-ESS; <i>n</i> = 20), and endometrial stromal nodule (ESN; <i>n</i> = 20). Immunohistochemical staining was performed using the PD-L1 (22C3) antibody, and PD-L1 expression was evaluated using the combined positive score. Clinicopathological parameters and PD-L1 expression were compared among tumor subtypes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients with HG-ESS demonstrated a significantly higher mean age at diagnosis compared with the other histopathological subtypes. PD-L1 expression was detected in 9 (45%) LMS, 10 (50%) HG-ESS, 3 (15%) LG-ESS, and 1 (5%) ESN cases, whereas no LM cases demonstrated positivity. PD-L1 expression rates were significantly higher in LMS and HG-ESS than in LM, LG-ESS, and ESN cases (<i>p</i> &lt; 0.0001). Combined group analyses also demonstrated significantly higher PD-L1 expression rates in the combined LMS/HG-ESS group compared with the LG-ESS group and the combined LM/ESN group (<i>p</i> &lt; 0.0001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings demonstrate increased PD-L1 expression in aggressive uterine mesenchymal tumors; however, the clinical and therapeutic significance of these immunohistochemical findings remains unclear. Further studies integrating PD-L1 expression with clinical findings and treatment outcomes are needed to determine the potential therapeutic relevance of PD-L1 in these neoplasms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 10","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149014714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Paternal Age: Implications on Fertility, Pregnancy Outcomes, and Offspring Health","authors":"Rana Mondal,&nbsp;Mouli Nandi,&nbsp;Ifra Iqbal","doi":"10.1111/jog.70505","DOIUrl":"10.1111/jog.70505","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To review associations between advanced paternal age (APA) and male reproductive health, assisted reproductive technology (ART) outcomes, pregnancy outcomes, and offspring health, to grade the evidence in each domain, and to address counseling implications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Narrative review with a structured, reproducible search. PubMed/MEDLINE was searched from 1 January 1990 to 4 September 2026 using controlled-vocabulary and free-text terms for paternal age and for reproductive, pregnancy, perinatal, and offspring outcomes, limited to human studies in English (1975 records), supplemented by hand-searching, Cochrane reviews, and professional society guidance. Systematic reviews, randomized trials, and large cohorts were prioritized, and confidence in each association was graded qualitatively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>APA (≥ 40 years) is consistently associated with lower semen volume, motility, and viability, higher sperm DNA fragmentation, and a linear increase in de novo mutations. Associations with reduced natural fecundability and modestly higher miscarriage risk are moderately consistent; ART outcomes are heterogeneous and largely attenuated once maternal age is controlled. Large registries show small but consistent associations with stillbirth, preterm birth, selected congenital anomalies, schizophrenia, and autism (relative effects mostly 1.1–3.0); associations with bipolar disorder, ADHD, childhood cancer, and cognitive outcomes are weaker or inconsistent. Because these outcomes are rare, absolute increments remain small. Paternal age alone is not an evidence-based indication for ICSI, sperm DNA fragmentation testing, preimplantation genetic testing, or other add-ons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>APA is associated with measurable changes in sperm biology and modest increases in relative risk for several adverse outcomes, most evident beyond 40 years. Nearly all evidence is observational and should not be read as causal. Paternal age warrants inclusion in reproductive counseling, communicated in absolute terms and without alarm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Ethical Issue</h3>\u0000 \u0000 <p>Beyond biological risks, APA raises concerns about long-term child welfare, emotional well-being, and potential socio-economic implications due to a greater risk of early parental loss.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 9","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Anxiety and Early Postoperative Recovery Among Women Undergoing Gynecologic Surgery in Vietnam: A Prospective Longitudinal Observational Study","authors":"Nguyen Thi Bich Van,&nbsp;Nguyen Thi Thuy Chung,&nbsp;Nguyen Ngoc Minh Hai,&nbsp;Trinh Quoc Huy","doi":"10.1111/jog.70501","DOIUrl":"10.1111/jog.70501","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To determine the prevalence of preoperative anxiety among women undergoing gynecologic surgery in Vietnam and evaluate its association with early postoperative pain, sleep disturbance, and functional status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective longitudinal observational study included 394 women scheduled for gynecologic surgery at a tertiary hospital in Hanoi, Vietnam, from May to December 2024. Preoperative anxiety was assessed using the Generalized Anxiety Disorder-7 scale. Preoperative information and counseling, perceived social support, and clinical characteristics were evaluated before surgery. Pain and functional status were assessed 48 h after surgery using the Numeric Rating Scale and Barthel Index, respectively, while the Insomnia Severity Index (ISI) was administered at the same assessment using its standard 2-week recall period. Multivariable linear and logistic regression models were performed to identify factors associated with preoperative anxiety and postoperative outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>One hundred thirty-one participants (33.2%) screened positive for anxiety symptoms (GAD-7 ≥ 5), with mild, moderate, and severe anxiety observed in 25.6%, 4.6%, and 3.0% of the cohort, respectively. Preexisting mental health conditions, lower perceived quality of preoperative information and counseling, and lower perceived support from significant others and friends were associated with higher preoperative anxiety scores. Higher preoperative anxiety was associated with greater postoperative pain intensity and higher ISI scores, but not with early functional status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Preoperative anxiety was highly prevalent among women undergoing gynecologic surgery and was associated with poorer early postoperative pain and sleep outcomes. Routine anxiety screening, improved preoperative communication, and targeted psychosocial support may contribute to more patient-centered perioperative care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 9","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}