Journal of Obstetrics and Gynaecology Research最新文献

{"title":"NINJ1 exerts a role in the development of preeclampsia through potential regulation by the Notch1 signaling pathway","authors":"Qin Shi,&nbsp;Panyun Gu,&nbsp;Yi Tang,&nbsp;Qianqian Ma,&nbsp;Yunzhao Xu","doi":"10.1111/jog.16295","DOIUrl":"https://doi.org/10.1111/jog.16295","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To explore NINJ1 expression in the placental tissue of preeclampsia patients, its correlation with patient status and pregnancy outcome, and offer preliminary insights into the relationship between NINJ1 and the Notch1 signaling pathway.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Placental tissue samples from PE and normal pregnancies were collected. NINJ1 expression was detected and compared between groups. Correlation with clinical data was analyzed. A PE cell model was established using hypoxia-treated cells. The Notch pathway inhibitor DAPT was used. Additionally, trophoblast cells were treated with different concentrations of the Notch pathway inhibitor DAPT. The CCK-8 assay and scratch test were used to assess cell proliferation and migration. The levels of NINJ1 and Notch signaling components were measured using qRT-PCR and western blot.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>NINJ1 expression was higher in PE placental tissues compared to normal tissues. Women in the PE group had a higher incidence of hypoproteinemia, thoracoabdominal effusions, premature deliveries, and a higher hospitalization rate for newborns compared to the normal group. NINJ1 protein expression in the PE group placental tissues was negatively correlated with newborn birth weight and the serum albumin level and positively correlated with the 24-h urinary protein and uric acid levels. NINJ1 expression was increased in trophoblast cells under hypoxic conditions, while Notch signaling pathway inhibition reduced the proliferation and migration abilities of trophoblast cells, downregulated Notch1, Hes1, and Hes5 protein expression, and significantly upregulated NINJ1 expression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>High expression of NINJ1 is associated with the occurrence of preeclampsia and adverse pregnancy outcomes, potentially regulated by the Notch1 signaling pathway.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Letter to “Will the day come when opinion and letter pieces disappear from the medical journals?”","authors":"Shigeki Matsubara","doi":"10.1111/jog.16302","DOIUrl":"https://doi.org/10.1111/jog.16302","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in factors influencing specialty choice in obstetrics and gynecology: A national survey of graduating senior residents","authors":"Kyosuke Kamijo,&nbsp;Tokumasa Suemitsu,&nbsp;Masako Hayashi,&nbsp;Yuki Iida,&nbsp;Ayana Ogawa,&nbsp;Yoko Kashima,&nbsp;Yoko Aoyagi,&nbsp;Satoshi Takemori,&nbsp;Takuma Ohsuga,&nbsp;Kazutoshi Nakano,&nbsp;Yu Ito,&nbsp;Hiroaki Komatsu,&nbsp;Kaori Koga,&nbsp;Fuminori Taniguchi","doi":"10.1111/jog.16299","DOIUrl":"https://doi.org/10.1111/jog.16299","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To analyze gender differences in factors influencing the choice of obstetrics and gynecology as a specialty and to inform gender-specific recruitment strategies for a more diverse and sustainable obstetrics and gynecology workforce.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This nationwide cross-sectional survey was conducted annually in Japan from 2019 to 2024, targeting post-senior residency obstetricians and gynecologists. The survey collected data on demographics, timing, reasons for choosing obstetrics and gynecology, and changes in concerns from pre- to post-senior residency.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The survey received 2049 responses out of 2458 distributed surveys, resulting in a response rate of 83.9% (60.6% female, 39.4% male). Moreover, 52.4% of respondents initially considered obstetrics and gynecology during medical school, with females more likely to consider it before medical school than males (24.8% vs. 17.3%). Clinical clerkship experience was the most common reason (57.7%), particularly among females compared to males (62.3% vs. 50.5%). However, males were more influenced by family members or relatives (6.9% vs. 13.1%) and lectures (8.6% vs. 12.6%) than females. Pre-residency concerns—physical burden, mental burden, night on-call demands, marriage and family planning, career path planning, litigation risks, and workforce shortages—were higher in females than in males, although these concerns decreased significantly post-residency, excluding those regarding workforce shortages and income. Male-specific concern about the “need for male physicians” decreased significantly from 32.3% to 11.9%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This nationwide survey provides valuable insights into the role of gender in specialty decision-making, with important implications for developing gender-specific recruitment strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microdissection testicular sperm extraction in male partner with non-obstructive azoospermia: Fresh or frozen–thawed sperm for intracytoplasmic sperm injection?","authors":"Sevinc Özmen,&nbsp;Esra Nur Tola","doi":"10.1111/jog.16298","DOIUrl":"https://doi.org/10.1111/jog.16298","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To compare the outcomes of intracytoplasmic sperm injection (ICSI) of fresh and cryopreserved sperm obtained via microdissection testicular sperm extraction (micro-TESE) in cases of non-obstructive azoospermia (NOA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 147 patients with NOA who underwent micro-TESE and obtained viable sperm via micro-TESE at Istanbul Medipol In Vitro Fertilization unit were recruited retrospectively. The cases were divided into two groups depending on the sperm used (fresh or frozen–thawed) for ICSI: The micro-TESE group (<i>n</i> = 93) underwent ICSI cycles with fresh spermatozoa and the micro-TESE-Thaw group (<i>n</i> = 54) underwent ICSI cycles with cryopreserved spermatozoa. Patient demographics, embryo development, and pregnancy outcomes were compared between the two groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No statistical difference was observed between the two groups in terms of demographic features (age, body mass index, etc.) and cycle characteristics (induction protocol, gonadotropin dose, etc.). Fertilization rates and embryo quality were also similar between the groups. Higher clinical pregnancy and live birth rates were observed in the micro-TESE group than in the micro-TESE-Thaw group (<i>p</i> &lt;0.04 and <i>p</i> &lt;0.003, respectively). The miscarriage rate was higher in the micro-TESE-Thaw group, although the difference did not reach statistical significance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion(s)</h3>\u0000 \u0000 <p>In cases where frozen sperm obtained by micro-TESE are used, even if viable and motile sperm are found after thawing, there may be a negative impact on the ICSI result. Fresh testicular spermatozoa appear to result in better clinical pregnancy and live birth rates than cryopreserved testicular spermatozoa in males with NOA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 5","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The persistence of HPV type-specific infections in patients following colposcopic examination: An observational study","authors":"Serkan Akis,&nbsp;Canan Kabaca,&nbsp;Yunus Emre Purut,&nbsp;Esra Keles,&nbsp;Ugur Kemal Ozturk,&nbsp;Mine Guray Uzun,&nbsp;Murat Api","doi":"10.1111/jog.16301","DOIUrl":"https://doi.org/10.1111/jog.16301","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>High-risk HPV infection is a necessary but not sufficient factor for the development of precancerous lesions and cervical cancer. Beyond mere HPV positivity, the persistence of infection over time plays a crucial role. This study aims to evaluate the clearance and persistence rates of HPV 16 and 18 genotypes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The cervical cytology results were reported using the 2014 Bethesda System classification. The cervical cytology samples were analyzed using the Roche Cobas® 4800 HPV tests. Patients with any HPV genotype other than 16 or 18, those with missing data, those who were lost to follow-up, those who underwent excisional procedures or hysterectomy, and those with high-grade cervical dysplasia were excluded from this study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 191 patients (mean age: 41.2 ± 0.6 years, 16.8% postmenopausal), the mean follow-up was 21.6 ± 0.7 months. No significant differences were found between the clearance and persistence groups in age, follow-up duration, cervical biopsy, or endocervical curettage results. However, HPV 16 had a higher persistence rate (28.2%), and abnormal cytology was more frequent in the persistence group (<i>p</i> = 0.038).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Around 25% of patients had persistent HPV infection. Close monitoring is essential for those with CIN 1 on initial colposcopy, as they may have a higher risk of progressing to high-grade dysplasia compared to those without dysplasia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of treatment and prognosis for clear cell carcinoma of the uterine cervix: 15-year experience at a single institution","authors":"Yusuke Inomata,&nbsp;Keisuke Kodama,&nbsp;Shoji Maenohara,&nbsp;Hiroshi Yagi,&nbsp;Masafumi Yasunaga,&nbsp;Ichiro Onoyama,&nbsp;Kazuo Asanoma,&nbsp;Hideaki Yahata,&nbsp;Yoshinao Oda,&nbsp;Kiyoko Kato","doi":"10.1111/jog.16300","DOIUrl":"https://doi.org/10.1111/jog.16300","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Clear cell carcinoma of the uterine cervix (CCCUC) is a rare disease, accounting for 4% to 9% of cervical adenocarcinomas. Because it is so rare, its pathogenesis is largely unknown, and the standard treatment is unclear due to a lack of prospective studies. Our aim is to investigate the clinical features, treatment, and prognosis of CCCUC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively evaluated the clinical characteristics, treatment choices, and outcomes of 12 patients with CCCUC treated at our institution between January 2009 and July 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median patient age was 62.5 years (range, 14–90 years). The most common stage was IB (IA, <i>n</i> = 3; IB, <i>n</i> = 4; IIB, <i>n</i> = 1; IIIC, <i>n</i> = 2; IVB, <i>n</i> = 2). Ten patients underwent surgery as initial treatment: 6 underwent radical hysterectomy plus pelvic lymphadenectomy (PLD) or sentinel lymph node biopsy (SLNB), with or without para-aortic lymphadenectomy (PALD); 3 underwent modified radical hysterectomy plus PLD with or without PALD; and 1 underwent radical trachelectomy with SLNB as fertility-preserving surgery. All patients underwent bilateral salpingo-oophorectomy except for the patient who opted for radical trachelectomy. Five patients received adjuvant treatment: 3 received platinum-based systemic chemotherapy (2 of whom had combination therapy with bevacizumab), and 2 received concurrent chemoradiotherapy. The median follow-up was 43.5 months (range, 1–123 months). The 5-year progression-free survival rate was 64.5%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Systemic platinum-based chemotherapy with bevacizumab may be more effective than concurrent chemoradiotherapy as adjuvant therapy for CCCUC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16300","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 76th Annual Congress of the Japan Society of Obstetrics and Gynecology","authors":"","doi":"10.1111/jog.16282","DOIUrl":"https://doi.org/10.1111/jog.16282","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 77th Annual Congress of the Japan Society of Obstetrics and Gynecology","authors":"","doi":"10.1111/jog.16285","DOIUrl":"https://doi.org/10.1111/jog.16285","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological classification of uterine cervical adenocarcinomas: Its alteration and current status","authors":"Masanori Yasuda,&nbsp;Tomomi Katoh,&nbsp;Yu Miyama,&nbsp;Taku Honma,&nbsp;Mitsutake Yano,&nbsp;Akira Yabuno","doi":"10.1111/jog.16287","DOIUrl":"https://doi.org/10.1111/jog.16287","url":null,"abstract":"<p>Adenocarcinomas (ADCs) of the uterine cervix are relatively minor compared to squamous cell carcinomas. However, ADCs are histologically and histogenetically unique, especially because they can be with or without human papillomavirus (HPV) infection. At present, ADCs are divided into tumors as HPV-associated ADCs (HA-ADCs) and HPV-independent ADCs (HI-ADCs), including adenocarcinomas in situ (AIS) as their precursor, both of which consist of variable histological types. The usual-type accounts for the majority of HA-ADCs, and the gastric-type is a representative of HI-ADCs. Notably, it is clinicopathologically significant to differentiate between HA-ADCs and HI-ADCs because of the discrepancy in prognosis between them. Although relatively rare in comparison with HPV-associated AIS (HA-AIS), HPV-independent AIS (HI-AIS) has gradually attracted attention since gastric-type ADC (g-ADC) was introduced in the World Health Organization Classification 4th ed. (2014). Occasional HA-ADCs and HI-ADCs, including HA-AIS and HI-AIS, require p16 immunostaining, in situ hybridization, or HPV testing to differentiate between them because morphological features alone cannot often be conclusive for the diagnosis. A system focusing on the infiltrative pattern has been introduced due to its clinicopathological value. Staging criteria of HA-ADCs with polypoid/exophytic growth, recommended by the International Collaboration on Cancer Reporting, may supplement the International Federation of Gynecology and Obstetrics staging system for clinical management and treatment.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16287","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between low-grade cervical cytology and histological cervical intraepithelial neoplasia concurrent vaginal intraepithelial neoplasia among outpatient colposcopy: A retrospective study","authors":"Min Lu,&nbsp;Xiping Luo,&nbsp;Qiaowen Bu,&nbsp;Peijuan Li,&nbsp;Wanting Luo,&nbsp;Shuling Ji,&nbsp;Huanxin Yue,&nbsp;Xiaoshan Hong","doi":"10.1111/jog.16289","DOIUrl":"https://doi.org/10.1111/jog.16289","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>There is evidence that cytological low-grade squamous intraepithelial lesion (LSIL) is associated with cervical intraepithelial neoplasia (CIN) in colposcopy, but its link to cervical intraepithelial neoplasia concurrent vaginal intraepithelial neoplasia (VaIN) remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective chart review was performed that encompassed patients who were pathologically diagnosed with CIN at a single center from 2017 to 2021. Demographics, referring cytology, HPV genotype, and histologic information were recorded. The primary outcome was CIN coexisted with VaIN.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 5488 patients included in this study (mean age, 37.0 years [SD 10]; 1376 [25.4]) had low-grade cervical cytology positive. A total of 458 participants were classified as having histologically CIN concurrent VaIN. Compared with participants without LSIL cytology, those with LSIL cytology had a higher prevalence of histological CIN concurrent VaIN (38.1% [172] vs. 24.2% [1204]). After adjusting for potential confounders, we found an association between LSIL cytology and histological CIN concurrent VaIN (odds ratio [OR], 3.28; 95% confidence interval [CI], 1.84–5.82). In subgroup analyses, LSIL cytology was associated with histological CIN concurrent VaIN among participants sexual life year 10 to 19 years (OR, 5.35; 95% CI, 1.58–18.04), gravidity 1–2 fetus (OR, 5.49; 95% CI, 1.62–18.61), HPV33 positive (OR, 90.06; 95% CI, 2.27–3579.46), HPV52 positive (OR, 9.09; 95% CI, 1.96–42.12).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In this cross-sectional study, LSIL cytology was associated with histological CIN concurrent VaIN in the outpatient colposcopy in adjusted models. This association may be important to consider in the colposcopy for the early detection of CIN concurrent VaIN.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16289","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}