Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Prenatal ultrasound diagnosis of intrauterine caput succedaneum: Case report","authors":"Chen Jiao,&nbsp;Guo Yuanyuan,&nbsp;Zhang Maochun","doi":"10.1111/jog.70081","DOIUrl":"10.1111/jog.70081","url":null,"abstract":"<p>Caput succedaneum typically forms during vaginal delivery. However, caput succedaneum in the fetal period is extremely rare. Here, we report two clinical cases in which intrauterine caput succedaneum was detected by prenatal ultrasound. Case 1: a 38-week pregnant woman was incidentally found to have fetal caput succedaneum during a routine obstetric ultrasound examination. Case 2: a 33⁺² week pregnant woman with preterm premature rupture of membranes was hospitalized for pregnancy maintenance. Fetal caput succedaneum was identified during a follow-up amniotic fluid volume assessment 1 week later. Following thorough antenatal counseling, all parents opted for cesarean delivery. At birth, physical examination revealed subtle, well-circumscribed scalp swellings with overlying hair; no bony defect was palpable. Consistent with the sonographic impression of benign scalp edema, the swellings resolved completely within the first week of life, and all neonates demonstrated normal growth and development at follow-up.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 9","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between ultrasonographic features and molecular markers of cancer cell proliferation, invasion, and apoptosis in young patients with advanced breast cancer","authors":"Hongmei Zhang,&nbsp;Lili Hu,&nbsp;Ping Li,&nbsp;Ge Sun","doi":"10.1111/jog.70073","DOIUrl":"10.1111/jog.70073","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to investigate the correlation between ultrasonographic features and the expression of genes (as molecular markers) related to cancer cell proliferation, invasion, and apoptosis in young patients with advanced breast cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 203 young patients with advanced breast cancer admitted to our hospital were enrolled and divided into a deceased group (<i>n</i> = 52) and a survival group (<i>n</i> = 151) based on overall survival status. Ultrasonographic features and expression levels of proliferation- (PKM2, Notch1), invasion-(Gab2, NUAK1), and apoptosis-related (Bcl-2) genes were compared between groups. The correlation between the Ki67 proliferation index and ultrasonographic features was also analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant differences between the deceased and survival groups were identified in internal echogenicity, margin, morphology, blood flow grade, BI-RADS classification, and calcification (<i>p</i> &lt;0.05). The deceased group exhibited significantly higher expression levels of PKM2, Notch1, Gab2, NUAK1, and Bcl-2 (<i>p</i> &lt;0.05). Spearman analysis revealed significant positive correlations between adverse ultrasonographic features and the expression of PKM2, Notch1, Gab2, NUAK1, and Bcl-2 (<i>p</i> &lt;0.01). Furthermore, Ki67 expression levels were significantly positively correlated with adverse features such as irregular margins, irregular morphology, and higher blood flow grade (<i>p</i> &lt;0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Proliferation-related genes (PKM2, Notch1), invasion-related genes (Gab2, NUAK1), the apoptosis-related gene Bcl-2, and the proliferation marker Ki67 are positively correlated with specific ultrasonographic features in young patients with advanced breast cancer, suggesting a link between imaging phenotypes and molecular markers of aggressiveness.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 9","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doppler abnormality predisposes preterm infants with fetal growth restriction to postnatal intestinal disorder","authors":"Tomohiro Ohtani,&nbsp;Mari Ichinose,&nbsp;Yu Ariyoshi,&nbsp;Miho Irie,&nbsp;Masatake Toshimitsu,&nbsp;Seisuke Sayama,&nbsp;Takahiro Seyama,&nbsp;Hiroshi Muto,&nbsp;Yoshihiko Shitara,&nbsp;Atsushi Ito,&nbsp;Mariko Yoshida,&nbsp;Satsuki Kakiuchi,&nbsp;Akio Ishiguro,&nbsp;Keiichi Kumasawa,&nbsp;Takayuki Iriyama,&nbsp;Jun Fujishiro,&nbsp;Naoto Takahashi,&nbsp;Yasushi Hirota,&nbsp;Yutaka Osuga","doi":"10.1111/jog.70075","DOIUrl":"10.1111/jog.70075","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Intestinal disorders (ID) impose a significant burden on preterm infants. Although previous studies have examined individual risk factors for types of ID such as necrotizing enterocolitis (NEC), meconium-related ileus (MRI), and focal intestinal perforation (FIP), the overarching etiology of ID as a whole remains underexplored. Therefore, this study aimed to identify obstetric risk factors for ID.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively investigated singletons without congenital anomalies born between 22 weeks 0 days and 28 weeks 6 days of gestation between January 2013 and December 2022. We compared the frequencies of obstetric factors between patients with ID (ID group) and those without (non-ID group). The obstetric risk factors were maternal background, complications, fetal growth restriction (FGR), chorioamnionitis, Apgar score, and umbilical artery blood gas.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 119 preterm infants were investigated. Of these, 22 (18.5%) had ID, including 14 MRI, 4 FIP, and 5 NEC cases. A total of 33 infants (27.7%) had FGR, which was more common in the ID group (10/22, 45.5% vs. 23/97, 23.7%, <i>p</i> = 0.047). Among patients with FGR, the median time from the onset of Doppler abnormalities in the umbilical artery, middle cerebral artery, or ductus venosus to delivery was significantly longer in patients with ID than in those without (180 h vs. 24 h, <i>p</i> = 0.049).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>FGR was potentially associated with ID in preterm infants. To our knowledge, this is the first study to highlight the impact of prolonged Doppler abnormalities on ID development. These findings suggest that a chronically stressful intrauterine environment may increase postnatal intestinal vulnerability.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 9","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and risk factor evaluation for postoperative nausea and vomiting in cesarean section under general anesthesia compared to the gynecologic surgery: A retrospective study","authors":"Su Yeon Kim,&nbsp;Seukyoung Hong,&nbsp;Jung-Won Hwang,&nbsp;Sang-Hwan Do,&nbsp;Hyo-Seok Na","doi":"10.1111/jog.70074","DOIUrl":"10.1111/jog.70074","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This retrospective study sought to investigate the incidence of postoperative nausea and vomiting (PONV) and its associated risk factors in patients undergoing cesarean section under general anesthesia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients who underwent cesarean section under general anesthesia or who underwent open gynecologic surgery were assigned to the OB group (<i>n</i> = 291) or the GY group (<i>n</i> = 225), respectively. The primary outcome was the incidence of PONV. Multivariable logistic regression analysis was performed to identify independent risk factors for PONV in the OB group. Propensity score matching was additionally conducted to facilitate a comparison of PONV incidence between the OB and GY groups (<i>n</i> = 66 in each group).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the OB group, 21 patients (7.2%) experienced PONV, which was significantly lower than the 68 patients (30.2%) in the GY group (<i>p</i> &lt; 0.001). This difference remained statistically significant after propensity score matching (15.2% in the OB group vs. 31.8% in the GY group; <i>p</i> = 0.019). In multivariable logistic regression analysis of the OB group, abdominal surgical history (<i>p</i> = 0.032), longer surgical duration (<i>p</i> = 0.017), lower fluid intake (<i>p</i> = 0.011), and higher estimated blood loss (<i>p</i> = 0.009) were associated with PONV.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>PONV may occur less frequently in patients undergoing cesarean section under general anesthesia than in those undergoing gynecologic surgery. In obstetric patients, substantial intraoperative blood loss with inadequate fluid replacement, prolonged surgical duration, and a history of abdominal surgery may represent additional risk factor for PONV.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 9","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.70074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145062770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-mutation of PCLO and SYNE1 defines an immune-activated endometrial cancer subtype with favorable prognosis","authors":"Caihong Wu,&nbsp;Dongmei Han,&nbsp;Xin Li,&nbsp;Dan Wang,&nbsp;Hao Jin","doi":"10.1111/jog.70077","DOIUrl":"10.1111/jog.70077","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Endometrial cancer (EC) is a genomically heterogeneous malignancy with diverse immune microenvironment profiles. Although POLE mutations and MSI-H status are established predictors of immunotherapy response, additional composite biomarkers that integrate mutational burden and immune activation are needed. PCLO and SYNE1 are frequently mutated structural genes in EC, yet their cooperative significance remains unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed 505 EC cases from The Cancer Genome Atlas (TCGA) and 95 additional samples from the Clinical Proteomic Tumor Analysis Consortium (CPTAC), stratifying tumors based on PCLO and SYNE1 mutation status. Genomic, transcriptomic, immunologic, and clinical features were compared between co-mutation and non-co-mutation groups. Differential expression gene and pathway enrichment were conducted to identify immune-related transcriptional programs. Survival analysis and nomogram were performed to assess prognostic impact.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PCLO and SYNE1 co-mutation defined a notable EC subtype with significant enrichment of POLE mutations, high tumor mutation burden (TMB), reduced aneuploidy, and elevated MSIsensor scores. Clinically, the overall survival (OS), progression-free survival (PFS), and disease-free survival (DFS) of the co-mutation group was significantly improved. Moreover, the co-mutation group exhibited increased infiltration of CD8⁺ T cells, M1 macrophages, and activated CD4⁺ memory T cells, as well as upregulation of immune checkpoint genes and chemokine signaling pathways. Finally, a nomogram incorporating co-mutation status outperformed conventional prognosticators and demonstrated high accuracy in survival prediction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>PCLO and SYNE1 co-mutation identifies a biologically distinct EC subset with heightened immunogenicity and superior prognosis. The co-mutation may serve as a robust, integrative biomarker for immune responsiveness and risk stratification in EC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 9","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of bowel mucosal invasion in epithelial ovarian cancer","authors":"Yusuke Toyohara,&nbsp;Atsushi Fusegi,&nbsp;Motoko Kanno,&nbsp;Sachiho Netsu,&nbsp;Terumi Tanigawa,&nbsp;Mayu Yunokawa,&nbsp;Hiroyuki Kanao","doi":"10.1111/jog.70076","DOIUrl":"10.1111/jog.70076","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Bowel mucosal invasion in epithelial ovarian cancer (EOC) is classified as stage IVB disease. However, the reason for this classification remains unclear, and the clinical outcomes of bowel mucosal invasion in EOC warrant further investigation. Therefore, we aimed to examine patients with EOC presenting with bowel mucosal invasion and evaluate the validity of the current classification.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively reviewed data from patients with stage IVB EOC who presented with bowel mucosal invasion at our hospital between January 2015 and September 2023. Patients with bowel mucosal invasion and other factors associated with stage IVB EOC were excluded. The primary and secondary endpoints were progression-free survival (PFS) and overall survival (OS), respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 226 patients diagnosed with stage IVB EOC, 22 (9.7%) exhibited bowel mucosal invasion and 13 (5.8%) were diagnosed with stage IVB EOC based solely on the presence of bowel mucosal invasion. The median follow-up period was 40.5 months (range, 14.9–81.6 months). Primary debulking surgery was performed in nine patients (69.2%) and neoadjuvant chemotherapy-interval debulking surgery in four (30.8%). Complete resection was achieved in all 13 patients without other stage IVB-related factors. Among them, the 3-year PFS and OS rates were 54.9% and 82.1%, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In cases of bowel mucosal invasion, complete resection appears feasible and may be associated with a more favorable prognosis compared with that of the overall stage IVB population. Therefore, bowel mucosal invasion alone may not represent a potential prognostic factor for stage IVB ovarian cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 9","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of preterm premature rupture of membranes: Antimicrobial stewardship and novel therapeutic strategies","authors":"Ya-Wen Zhong,&nbsp;Xiu-Fang Wang,&nbsp;Hong Ding,&nbsp;Sui-Jin Zheng,&nbsp;Cai-Hong Wang,&nbsp;Rui-Man Li","doi":"10.1111/jog.70020","DOIUrl":"10.1111/jog.70020","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Preterm premature rupture of membranes (PPROM) is a major contributor to preterm birth and is associated with increased risks of maternal and neonatal complications. The aim of this review is to summarize current antibiotic strategies and explore emerging adjunctive therapies, including probiotics, amnioinfusion, and fetal membrane repair, to improve the management of PPROM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Relevant literature on antibiotic therapy for PPROM and emerging treatment strategies was systematically retrieved from PubMed. The data were analyzed to compare standard antibiotic protocols with personalized and combination regimens.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Evidence indicates that adjusting antibiotic duration and adopting precision-based regimens may improve clinical efficacy while minimizing adverse effects. Moreover, probiotics, amnioinfusion, and fetal membrane repair hold promise in alleviating infection-related inflammation and improving pregnancy outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Optimizing antibiotic therapy via individualized approaches and incorporating adjunctive treatments could enhance the management of PPROM. Future research ought to concentrate on pinpointing biomarkers for personalized antibiotic selection, evaluating combination therapies, and assessing long-term maternal–fetal outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 9","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of surgical outcomes between robotic and laparoscopic sacrocolpopexy with concomitant total hysterectomy for pelvic organ prolapse: A retrospective cohort study","authors":"Kuniaki Ota,&nbsp;Toshifumi Takahashi,&nbsp;Yoshiaki Ota,&nbsp;Kayo Tsuji,&nbsp;Keitaro Tasaka,&nbsp;Hana Okamoto,&nbsp;Shogo Kawamura,&nbsp;Wataru Saito,&nbsp;Mitsuru Shiota,&nbsp;Koichiro Shimoya","doi":"10.1111/jog.70068","DOIUrl":"10.1111/jog.70068","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to compare short- and long-term surgical outcomes between robotic sacrocolpopexy (RSC) and laparoscopic sacrocolpopexy (LSC), performed with concomitant total hysterectomy, in patients with symptomatic pelvic organ prolapse (POP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study included 167 women who underwent RSC (<i>n</i> = 113) or LSC (<i>n</i> = 54) with hysterectomy for uterine prolapse at Kawasaki Medical University between March 2020 and December 2024. Perioperative parameters, complications (Clavien–Dindo classification), and POP recurrence were assessed. The POP-Q was used for anatomical evaluation. Long-term outcomes such as recurrence, urinary incontinence, and mesh erosion were monitored over a median follow-up of 30 (RSC) and 52.5 (LSC) months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The patients in the RSC group were significantly younger and had a higher incidence of diabetes. RSC had longer operative times (median 175 min vs. 152 min; <i>p</i> &lt; 0.01) but comparable blood loss, complication rates, and hospital stay. POP-Q showed greater cervical elevation in the RSC group at one month (<i>p</i> &lt; 0.05). The long-term recurrence rate was low and similar between the groups (RSC, 2.7%; LSC, 3.7%; <i>p</i> = 0.71). Mesh erosion, urinary incontinence, and organ prolapse were rare and did not differ significantly between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>RSC with concomitant hysterectomy is a safe and effective alternative to LSC with comparable short- and long-term outcomes. Despite longer operative times, RSC offers anatomical benefits without increasing the risk of postoperative complications or recurrence.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 9","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145012396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the microbiome in endometrial carcinoma: Pathogenesis, biomarkers, and therapeutic prospects","authors":"Wafa Abdalla,&nbsp;Wisam Nabeel Ibrahim,&nbsp;Atiyeh M. Abdallah,&nbsp;Maha Abdulla Al-Asmakh,&nbsp;Sawsan Sudqi Said","doi":"10.1111/jog.70070","DOIUrl":"10.1111/jog.70070","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Recent studies show that human microbiomes play a significant role in the development of endometrial carcinoma, which is a common gynecological cancer affecting women of reproductive age. This review provides an extensive analysis of how the microbiome interacts with endometrial carcinoma while focusing on its impact on disease progression and potential therapeutic advancements.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Extensive literature research was conducted to examine how microbial dysbiosis affects endometrial cancer development. The research analyzed both animal model studies and clinical cohort data to assess how microbiome composition influences cancer risk and progression alongside treatment outcomes. The research explored possible microbiome interventions alongside the translational challenges they present.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>New research findings demonstrate that microbial imbalance contributes to endometrial cancer development through chronic inflammatory processes and estrogen metabolism changes while affecting immune system behavior in the tumor microenvironment. Scientists are exploring unique microbial patterns to serve as biomarkers for detecting diseases and predicting treatment outcomes. Microbiome-targeted strategies, including probiotics and diet changes, demonstrate the potential to enhance treatment results for individuals receiving immunotherapy and chemotherapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This review examines the detailed interactions between the microbiome and endometrial carcinoma and outlines their importance in developing predictive models and innovative treatments. We explore both the obstacles faced in applying microbiome research to clinical settings and potential research paths that could speed up the integration of microbiome-based therapies into patient healthcare.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 9","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.70070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145012395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative assessment of placental alpha macroglobulin-1 for predicting impending preterm delivery in asymptomatic women with a short cervix","authors":"Yuki Nozaki,&nbsp;Kenji Imai,&nbsp;Rika Miki,&nbsp;Sho Tano,&nbsp;Kazuya Fuma,&nbsp;Seiko Matsuo,&nbsp;Takafumi Ushida,&nbsp;Hiroaki Kajiyama,&nbsp;Tomomi Kotani","doi":"10.1111/jog.70071","DOIUrl":"10.1111/jog.70071","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Preterm delivery (PTD) is a leading cause of neonatal morbidity and mortality. Accurate prediction is crucial for optimizing clinical outcomes, particularly in women with a short cervix. Although fetal fibronectin (FFN) is widely used to predict PTD, placental alpha-microglobulin-1 (PAMG-1) has gained attention for its potential to improve predictive accuracy. This study aimed to evaluate the utility of quantitative PAMG-1 assessment for predicting impending PTD in asymptomatic women with a short cervix (≤25 mm) between 24 and 34 weeks of gestation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This observational cohort study analyzed 212 cervicovaginal fluid samples from 77 patients (132 from 49 singleton and 80 from 28 twin pregnancies). PAMG-1 and FFN levels were measured, and multivariate logistic regression was performed to evaluate their association with PTD risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In singleton pregnancies, positive PAMG-1 was independently associated with impending PTD, with odds ratios of 7.84 (95% confidence interval [CI], 2.02–30.50; <i>p</i> = 0.003) and 7.34 (95% CI, 2.75–19.60; <i>p</i> &lt; 0.001) for PTD within 1 and 2 weeks, respectively. Quantitative PAMG-1 showed a dose-dependent relationship, with PTD risks increasing from 4.3% (&lt;1000 pg/mL) to 50.0% (≥3000 pg/mL) within 1 week and from 10.0% to 90.0% for PTD within 2 weeks. In twin pregnancies, both PAMG-1 and FFN showed limited predictive utility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study highlights the potential of PAMG-1 quantification as a valuable tool for refining PTD risk stratification, particularly in singleton pregnancies. While further prospective multicenter validation is needed, these findings provide new clinical insights for improving PTD management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 9","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.70071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144998718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}