Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Predictive score using umbilical vein leucine-rich α-2 glycoprotein as a useful biomarker for diagnosing histological chorioamnionitis in preterm infants","authors":"Genichiro Sotodate,&nbsp;Satoshi Serada,&nbsp;Mitsumasa Osakabe,&nbsp;Fumiaki Takahashi,&nbsp;Atsushi Matsumoto,&nbsp;Yukiko Toya,&nbsp;Shigekuni Tsuchiya,&nbsp;Minoru Fujimoto,&nbsp;Tetsuji Naka,&nbsp;Manami Akasaka","doi":"10.1111/jog.16344","DOIUrl":"https://doi.org/10.1111/jog.16344","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>We investigated the value of leucine-rich α-2 glycoprotein (LRG) in cord blood for diagnosing histological chorioamnionitis (HCAM) in preterm infants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective cohort study included 68 infants, born between 22 and 31 weeks of gestation, comprising 29 infants without and 39 infants with HCAM. Maternal, infant, and cord blood inflammatory markers were compared between the groups, and expression levels were compared using immunohistopathological staining of placental tissue.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The umbilical vein leucine-rich α-2 glycoprotein (UV-LRG) and gestational age were independent risk factors for HCAM (odds ratio [OR] 2.395, 95% confidence interval [CI] 1.230–4.663, OR 0.678, 95% CI 0.492–0.934, respectively). The predictive score was calculated as follows: 9.575 + (−0.386) × gestational age + 0.756 × UV-LRG. The predictive score (area under the curve 0.802, 95% CI [0.696–0.958]) appeared to be a reliable diagnostic model for HCAM and outperformed other inflammatory markers. At a cut-off value of 0.852, the predictive score showed a sensitivity of 57.1% and specificity of 93.1% for diagnosing HCAM. Immunohistopathological evaluation of the placenta revealed stronger LRG expression in the trophoblasts (TBs) and stroma in the group with HCAM than in the group without UV-LRG levels correlated positively with the immunohistopathological LRG intensity in the TBs and stroma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The predictive score using UV-LRG is a more useful biomarker than the other inflammatory markers for HCAM diagnosis. Investigating the mechanism by which TBs produce LRG and by which LRG migrates from the TBs to the stroma may help elucidate HCAM pathogenesis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angle of progression as a potential risk factor for emergency cesarean section following induction of labor in Japanese nulliparous women at term","authors":"Satoshi Shinohara,&nbsp;Rei Sunami,&nbsp;Genki Yasuda,&nbsp;Mayuko Kasai","doi":"10.1111/jog.16343","DOIUrl":"https://doi.org/10.1111/jog.16343","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To examine the association between the angle of progression (AOP) measured before labor induction and the occurrence of emergency cesarean section (ECS). Additionally, a predictive model was developed for ECS following labor induction using sonographic and clinical data accessible to obstetricians.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective observational cohort study was conducted at the Yamanashi Prefectural Central Hospital between January 2022 and July 2024. A total of 143 nulliparous Japanese women with singleton term pregnancies in the cephalic presentation were recruited. Transabdominal and transperineal ultrasound examinations were performed before labor induction. All variables with a <i>p</i>-value of &lt;0.05 in the bivariate analysis were evaluated using multivariable logistic regression analysis to examine the association between AOP and ECS and to identify AOP cutoff values predictive of ECS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The incidence of ECS was 39.9% (57/143). Multivariable analysis indicated that the AOP (adjusted odds ratio [OR]: 0.89, 95% confidence interval [CI]: 0.85–0.94) and pre-pregnancy body mass index (adjusted OR: 1.14, 95% CI: 1.03–1.27) were associated with ECS. The prediction model had a sensitivity and specificity of 82.5% and 82.6%, respectively (area under the curve [AUC] = 0.88). The optimal AOP cutoff point for predicting ECS was 91.2° (AUC: 0.77).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The ECS prediction model incorporating AOP may facilitate individualized counseling before labor induction. Women with an AOP less than 91.2° are at an elevated risk for ECS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and predictors of non-alcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD) in Indian women with polycystic ovarian syndrome","authors":"Aditi Rathi,&nbsp;Deepti Goswami,&nbsp;Anju Garg,&nbsp;Smita Kaushik,&nbsp;Niharika Dhiman","doi":"10.1111/jog.16335","DOIUrl":"https://doi.org/10.1111/jog.16335","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To study the prevalence and predictors of non-alcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD) in women with polycystic ovarian syndrome (PCOS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Seventy-eight PCOS patients and 78 age and body mass index (BMI)-matched controls were studied. PCOS was diagnosed by Rotterdam criteria. Clinical examination, biochemical, and hormonal investigations, and transabdominal sonography were done for all participants. Based on gray-scale sonography, NAFLD was graded as 0, 1, 2, and 3. MAFLD was diagnosed when imaging or serological evidence of fatty liver disease was present and one of the following three criteria was met: overweight/obesity, diabetes, or metabolic disorders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Women with PCOS had a higher prevalence of NAFLD (53.8% vs. 17.9%; <i>p</i> &lt; 0.001), MAFLD (70.5% vs. 48.7%; <i>p</i> &lt; 0.01), insulin resistance (HOMA-IR 2.8 ± 1.3 vs. 1.4 ±0.3; <i>p</i> &lt; 0.001) and metabolic syndrome (51.3% vs. 10.3%; <i>p</i> &lt; 0.001) and higher values of waist-hip ratio (0.88 ± 0.1 vs. 0.83 ± 0.1; <i>p</i> &lt; 0.001), alanine transferase (44.1 ± 19.7 vs. 30.3 ± 7.6; <i>p</i> &lt; 0.001), and free androgen index (FAI; 7.8 ± 4.4 vs. 3.4 ± 1.7; <i>p</i> &lt; 0.001) than controls. Twenty-three percent of PCOS patients with NAFLD and 18.4% with MAFLD had Grades 2 and 3 disease. Among different PCOS phenotypes, phenotype A was maximally affected with NAFLD and MAFLD. Multiple regression analysis showed that PCOS status and FAI were the predicting factors for NAFLD. MAFLD was significantly associated with hepatic steatosis index (HSI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PCOS patients were at a higher risk for NAFLD and MAFLD than age- and BMI-matched controls. The prevalence of NAFLD and MAFLD was highest in phenotype A. Hyperandrogenism is a predictor of NAFLD in PCOS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative outcomes in patients with very low-risk endometrial cancer undergoing surgery without lymph node dissection: Results from KGOG 2021","authors":"Dae Hoon Jeong,&nbsp;Yong Beom Kim,&nbsp;Kidong Kim,&nbsp;Jong-Min Lee,&nbsp;Dae Gy Hong,&nbsp;Jaeman Bae,&nbsp;Kwang-Beom Lee,&nbsp;Chae Hyeong Lee,&nbsp;Myong Cheol Lim,&nbsp;Min Kyu Kim","doi":"10.1111/jog.16342","DOIUrl":"https://doi.org/10.1111/jog.16342","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the perioperative outcomes of patients with endometrial cancer meeting the Korean Gynecologic Oncology Group (KGOG) criteria who underwent surgery without lymph node dissection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included 153 patients who met the KGOG criteria: (1) endometrioid histology, (2) myometrial invasion &lt;50%, (3) tumor confined to the corpus, (4) no lymph node &gt;1 cm, and (5) serum CA125 ≤ 35 U/mL. The patients underwent surgery without lymph node dissection at 11 hospitals in Korea between February 2020 and May 2024. Perioperative outcomes were collected prospectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 153 patients, 89 (58%) underwent surgery without lymph node removal, while 64 (42%) underwent surgery with lymph node removal. Minimally invasive surgery was performed in &gt;90% of cases, with a conversion rate to laparotomy of 1%. The mean surgery time was 109.37 ± 37.67 min. Estimated blood loss was minimal (93.74 ± 93.13 mL), with a mean hemoglobin drop of 1.32 ± 1.01 g/dL. Transfusions were required in only three patients (2%). Postoperative hospital stays exceeded 2 days in 51% of cases. Lymph node metastasis was observed in just one case (1%). Adverse events included 52 grade 1 and 2 grade 2 events (e.g., headache, paresthesia). Patients undergoing lymph node removal (primarily sentinel lymph node biopsy) had significantly longer surgery times and postoperative hospital stays compared to those without lymph node removal.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Surgery without lymph node dissection demonstrated excellent perioperative outcomes and minimal adverse events in patients meeting KGOG criteria.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16342","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of the prognostic nutritional index in the first trimester on birth weight: A retrospective study","authors":"Arife Akay,&nbsp;Yıldız Akdaş-Reis,&nbsp;Khurshud Hajıyeva,&nbsp;Neval Çayonu-Kahraman,&nbsp;Yaprak Engin-Üstün","doi":"10.1111/jog.16341","DOIUrl":"https://doi.org/10.1111/jog.16341","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The study aimed to investigate the effect of the maternal prognostic nutritional index (PNI) in the first trimester on birth weight.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study was conducted on term births between 2015 and 2022. The subjects were classified into three categories based on their birth weight: small gestational age (SGA), adequate gestational age (AGA), and large gestational age (LGA). The values of PNI, albumin (ALB), and hemoglobin (HB) were determined in the first trimester. PNI, ALB, and HB levels, demographic, obstetric, and neonatal outcomes were compared in the three groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 302 singleton pregnancies were included, with 79 cases classified as SGA (26.2%), 147 cases as AGA (48.6%), and 76 cases as LGA (25.2%). The mean ages and body mass index (BMI) of the groups were found to be similar (<i>p</i> &lt; 0.05). HB (12.3 ± 1.28 g/dL), ALB (3.5 ± 0.37 g/dL), and PNI (35.7 ± 3.78) levels were found to be lower in the SGA group (<i>p</i> &lt; 0.05). The cut-off values for ALB and PNI were 3.5 g/dL and 35, respectively (80.3% and 81% sensitivity and 54.4% specificity). A positive correlation was identified between the 1 min Apgar score and both ALB and PNI (<i>p</i> = 0.002, <i>r</i> = 0.176).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>A reduction in PNI, HB, and ALB levels was observed in the SGA group, whereas no significant difference was identified in the LGA group. To achieve an adequate birth weight, it is recommended that the nutritional status and anemia of the mother be improved before and during pregnancy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of drospirenone as a progestin-only pill in Japanese women: A phase III study","authors":"Kunio Kitamura,&nbsp;Enrico Colli,&nbsp;Ryoko Kikuyama,&nbsp;Yumiko Kurihara,&nbsp;Rieko Azuma,&nbsp;Tomoya Kagawa","doi":"10.1111/jog.16340","DOIUrl":"https://doi.org/10.1111/jog.16340","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the efficacy and safety of 4 mg of drospirenone (DRSP), a progestin-only pill (POP), for contraception in Japanese women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a multicenter, open-label, single-arm study. The dosing period of DRSP was 13 cycles, each lasting for 28 days. In one cycle, 4 mg of DRSP was administered orally once daily for the first 24 days, followed by a placebo for 4 days.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Data from 276 subjects were analyzed, with a total of 3319 DRSP exposure cycles. Pregnancy occurred in one subject. The overall Pearl Index [95% CI] was 0.39 [0.01, 2.18], and the cumulative pregnancy rate [95% CI] was 0.40% [0.06, 2.81]. Of the 276 subjects, 273 (98.9%) experienced treatment-emergent adverse events (TEAEs) and 264 (95.7%) experienced adverse drug reactions. All TEAEs were mild or moderate, with no severe events. The most common TEAE was intermenstrual bleeding (irregular uterine bleeding) (89.5%). Although 31.9% of the subjects had risk factors for venous thromboembolism (VTE), no VTE-related TEAEs were observed. The incidence of unscheduled bleeding [95% CI] across all cycles was 91.6% [87.7, 94.3].</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>DRSP, the first POP in Japan, is effective and safe as a contraceptive in Japanese women. It provides a new contraceptive option for Japanese women, including those at risk of VTE for whom combined oral contraceptives are contraindicated.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16340","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug development for adenomyosis based on pathophysiology","authors":"Sun-Wei Guo","doi":"10.1111/jog.16322","DOIUrl":"https://doi.org/10.1111/jog.16322","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Adenomyosis is a common uterine disease second only to uterine leiomyoma. Its management often requires medical treatment. However, practically no drug has ever been developed exclusively for adenomyosis. Development of non-hormonal drugs for adenomyosis so far has been unsuccessful. In this review, challenges in the development of non-hormonal drugs for adenomyosis are spelled out, an overview of current knowledge on the pathophysiology of adenomyosis is provided, and some promising avenues for drug development are outlined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Published studies are reviewed and trials on adenomyosis registered at ClinicalTrials.gov are also reviewed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Results</h3>\u0000 \u0000 <p>A survey of the interventional trials on new drugs gave a grim picture. Among seven trials on four classes of new drugs, a single trial on aromatase inhibitors reported symptom improvement but was marred by data authenticity concerns; the only trial on oxytocin receptor (OTR) antagonist was withdrawn, two trials on dopamine receptor D2 (DRD2) agonists yielded conflicting results, and the only trial on ulipristal acetate was completed but not reported and presumed to have failed. The only drug that is reported to be efficacious is mifepristone, an old drug that induces amenorrhea in 90% of patients.</p>\u0000 \u0000 <p>On the bright side, a mouse model that apparently recapitulates one subtype of adenomyosis became available fairly recently. The big picture of the natural history of adenomyotic lesions has become clear, and the mechanisms underlying adenomyosis-induced heavy menstrual bleeding are being unveiled. Along these lines, several drugs have been tested in preclinical settings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>With a better understanding of adenomyosis pathophysiology, more druggable targets will be discovered.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA TTC28-AS1 promotes the progression of cervical cancer by targeting miR-377-3p","authors":"Nianhong Yang,&nbsp;Tingting Xia,&nbsp;Ying Huang","doi":"10.1111/jog.16331","DOIUrl":"https://doi.org/10.1111/jog.16331","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Cervical cancer (CC) is the fourth most common malignancy affecting women worldwide and has a poor prognosis. The aim of this study was to investigate the clinical significance and mechanism of TTC28-AS1 in CC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 120 individuals suffering from CC were included in this study. RT-qPCR was used to detect the level of TTC28-AS1, and the prognostic value of TTC28-AS1 was analyzed by Kaplan–Meier curve and Cox regression analyses. Dual-Luciferase reporter assay was used to verify the targeting relationship between TTC28-AS1 and miR-377-3p. The proliferative ability of CC cells was detected by CCK-8 kit. The migration and invasion of CC cells were detected by transwell system.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The expression level of TTC28-AS1 was elevated in patients with CC, serving as an indicator of unfavorable clinical outcome. TTC28-AS1 may promote the proliferation, migration, and invasion of CC cells by targeting miR-377-3p.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>TTC28-AS1 has the potential to promote the malignant progression of CC by targeting miR-377-3p, thus emerging as a promising therapeutic target for the treatment of CC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of diffuse uterine leiomyomatosis for fertility preservation: Case series and systematic literature review","authors":"Kiko Yamamoto,&nbsp;Kaoru Kawasaki,&nbsp;Kosuke Murakami,&nbsp;Yasushi Kotani,&nbsp;Noriomi Matsumura","doi":"10.1111/jog.16332","DOIUrl":"https://doi.org/10.1111/jog.16332","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of this study was to evaluate the surgical, reproductive, and perinatal outcomes of patients with diffuse uterine leiomyomatosis desiring fertility preservation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients diagnosed with diffuse uterine leiomyomatosis based on magnetic resonance imaging at Kindai University Hospital between 2017 and 2024 were included in a case series. A systematic literature review on diffuse uterine leiomyomatosis desiring fertility preservation was carried out.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The case series showed that fertility preservation was desired in 8 of 18 cases, of which 1 was conceived after assisted reproductive technology and underwent cesarean section at 34 weeks of gestation for placenta previa accreta. A systematic literature review identified 31 cases from descriptive observational studies (1–8 cases per study). Although more fibroids (<i>n</i> = 87) were enucleated by extensive myomectomy than by hysteroscopic myomectomy (<i>n</i> = 33) (<i>p</i> &lt; 0.0001), extensive myomectomy was often associated with massive blood loss and blood transfusion. Perinatal complications were more frequent in extensive myomectomy (5/7) compared to hysteroscopic myomectomy (2/12, <i>p</i> = 0.04). Preterm delivery before 36 weeks was more frequent in extensive myomectomy (4/6 cases) than in hysteroscopic myomectomy (1/11 cases, <i>p</i> = 0.03).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Fertility preservation in diffuse uterine leiomyomatosis was previously considered difficult, but it is now recognized to be possible. Hysteroscopic myomectomy is a minimally invasive option. If conception is not achieved, extensive myomectomy may be considered. However, extensive myomectomy is more invasive, with a higher risk of perinatal complications. Large-scale clinical trials are required to establish a management standard for diffuse uterine leiomyomatosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16332","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preconception health assessments in occupational settings: Counseling versus written feedback","authors":"Akiko Fujishima,&nbsp;Eri Maeda,&nbsp;Koki Sato,&nbsp;Hidekazu Saito,&nbsp;Yuka Uchikura,&nbsp;Takashi Sugiyama,&nbsp;Yukihiro Terada","doi":"10.1111/jog.16337","DOIUrl":"https://doi.org/10.1111/jog.16337","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Our preconception care (PCC) initiative in Akita (Japan) was previously reported to improve health literacy and motivate behavioral changes. To make the check-up widely available, a more feasible and sustainable system is necessary. Our aim was to evaluate a resource-efficient preconception check-up implemented in Ehime Prefecture.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The Ehime PCC check-up included female employees aged 18–39 and took place between July 2023 and January 2024. Participants attended a lecture, underwent blood tests, and received written feedback. Pre- and post-intervention surveys were conducted for check-up evaluation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty-nine women (median age: 31 years) participated. The results revealed that their health was inadequate for future pregnancies, with 23% exhibiting anemia (hemoglobin &lt;12.0 g/dL) and 29% iron deficiency (serum ferritin &lt;12 ng/mL). Furthermore, all participants had low 25-hydroxyvitamin D levels (&lt;30 ng/mL). After receiving written feedback, 66% manifested an intention to improve their lifestyle, 21% an intention to consult an obstetrician and gynecologist, and 32% expressed a desire to become pregnant sooner. The proportion of those without intention to change their future behavior was significantly higher in Ehime (23.7%) compared to Akita (4.9%, <i>p</i> = 0.018). Recommendation ratings were significantly lower in Ehime (strongly recommend: 18.2% vs. 65.9%, <i>p</i> &lt; 0.001), with more reporting anxiety (10.5% vs. 4.9%, <i>p</i> = 0.02).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Preconception check-ups improved the intention to change behavior, even in resource-efficient settings. However, individual counseling may be more effective than written feedback in increasing the intention to change behavior and satisfaction. A resource-efficient feedback method that effectively motivates behavioral change and improves satisfaction is required.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 6","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16337","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}