Eosinophils and other blood cell traits in the risk of infertility population: A Mendelian randomization analysis

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-06-18 DOI:10.1111/jog.16347

Shiqi Yi, Ying Feng, Yuping Zhang, Linyu Zhang, Xinrui Sun, Yi Zhang, Qianhong Ma, Fang Ma

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Abstract

Background

Abnormalities in blood cell parameters, including eosinophil traits, have been implicated in reproductive system damage. However, their specific relationship with infertility and abnormal spermatozoa remains unclear.

Objective

In this study, we investigated 23 blood cell parameters, including eosinophil traits, using bidirectional Mendelian randomization analysis to explore their causal relationship with male and female infertility.

Methods

We utilized data from the INTERVAL study, UK Biobank, Blood Cell Consortium, and GWAS Catalog for 23 blood cell parameters, as well as GWAS data from the FinnGen database for two infertile populations and one clinical phenotype related to infertility. MR analysis was conducted employing various methods, including inverse-variance weighting (IVW), to obtain statistically significant results.

Results

Among the blood cell parameters examined, three were associated with the risk of male infertility: eosinophil percentage of granulocytes, eosinophil cell count, and mean sphered cell volume. Among these, eosinophil levels exhibited the most significant correlation with male infertility. In contrast, no blood cell traits were identified as risk factors for female infertility. However, basophil cell count and hemoglobin concentration-related traits appeared to serve as protective factors for female infertility.

Conclusion

Abnormal eosinophil levels may increase the risk of male infertility. However, given the limitations inherent in the observational design of this MR study, further research is required to assess the potential therapeutic effects of eosinophil reduction in idiopathic male infertility. Regarding female infertility, the study suggests that certain blood cell traits, such as basophil cell count, may act as protective factors, which warrants further investigation.

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嗜酸性粒细胞和其他血细胞特征在不孕症人群中的风险：孟德尔随机分析

背景血细胞参数异常，包括嗜酸性粒细胞特征，与生殖系统损伤有关。然而，它们与不孕症和异常精子的具体关系尚不清楚。目的采用双向孟德尔随机分析方法，对23项血细胞参数（包括嗜酸性粒细胞特征）进行分析，探讨其与男性和女性不育的因果关系。方法利用来自INTERVAL研究、UK Biobank、Blood Cell Consortium和GWAS目录的23个血细胞参数数据，以及来自FinnGen数据库的2个不育人群和1个与不育相关的临床表型的GWAS数据。采用反方差加权（IVW）等多种方法进行MR分析，获得具有统计学意义的结果。结果在检查的血细胞参数中，有三个与男性不育的风险相关：粒细胞的嗜酸性百分比，嗜酸性细胞计数和平均球形细胞体积。其中，嗜酸性粒细胞水平与男性不育的相关性最显著。相比之下，没有血细胞特征被确定为女性不育的危险因素。然而，嗜碱性细胞计数和血红蛋白浓度相关特征似乎是女性不孕症的保护因素。结论嗜酸性粒细胞水平异常可增加男性不育的风险。然而，考虑到这项MR研究的观察性设计固有的局限性，需要进一步的研究来评估减少嗜酸性粒细胞对特发性男性不育症的潜在治疗效果。关于女性不孕症，研究表明，某些血细胞特征，如嗜碱性细胞计数，可能是保护因素，这值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.