Effects of ubiquinol intake on improving menstrual symptoms among female healthcare workers: An open-label pilot study

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-03-27 DOI:10.1111/jog.16279

Tetsu Kinoshita, Koutatsu Maruyama, Kikumi Katakami, Takayo Sakiyama

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引用次数: 0

Abstract

Aim

This study aimed to investigate the effects of ubiquinol on menstrual symptoms.

Methods

This open-label trial involved 86 female healthcare workers aged 21–48 years. The study design included an observation period and a ubiquinol intake period. During the intake period, the participants consumed two soft capsules containing 75 mg of ubiquinol daily (i.e., 150 mg/day). At baseline and after the observation and intake periods, the participants underwent blood testing and completed the Pittsburgh Sleep Quality Index to evaluate their sleep condition. In addition, the Menstrual Distress Questionnaire was completed before, during, and after each of the first seven menses. All statistical analyses were performed, stratified by the median age of the participants.

Results

Regarding the Menstrual Distress Questionnaire, in the younger group (age: <36 years), a significant improvement was observed in menstrual “Control” (p = 0.049) by ubiquinol intake. In the older group (age: ≥36), the effects of ubiquinol on the improvement of premenstrual “Negative affect” and “Control” scores reached significance (p = 0.02 and p < 0.01, respectively); further, menstrual “Control” score was significantly improved (p = 0.03). In addition, the Pittsburgh Sleep Quality Index showed a significant effect of ubiquinol in the older group.

Conclusions

This pilot study indicated that ubiquinol alleviated menstrual symptoms among premenopausal female healthcare workers. In those aged ≥36 years, ubiquinol intake may reduce premenstrual irritability and improve sleep quality.

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泛醇摄入对改善女性保健工作者月经症状的影响：一项开放标签的试点研究

目的探讨泛醇对月经症状的影响。方法86例21 ~ 48岁的女性医护人员参与开放标签试验。研究设计包括一个观察期和一个泛醇摄入期。在摄入期间，参与者每天食用两粒含有75毫克泛醇的软胶囊（即150毫克/天）。在基线和观察和摄入期之后，参与者接受了血液测试并完成了匹兹堡睡眠质量指数来评估他们的睡眠状况。此外，在前七次月经之前、期间和之后分别填写月经困扰问卷。所有的统计分析都按照参与者的年龄中位数进行分层。结果在月经困扰问卷调查中，年轻组（36岁）服用泛醇后，月经“控制”有显著改善（p = 0.049）。在年龄≥36岁的老年患者中，泛醇对经前“负性情绪”和“控制性情绪”评分的改善效果均有显著性意义（p = 0.02和p <； 0.01）；月经“控制”评分显著提高（p = 0.03）。此外，匹兹堡睡眠质量指数显示，泛醇对老年人有显著影响。结论本初步研究表明泛醇可缓解绝经前女性医护人员的月经症状。在年龄≥36岁的人群中，摄入泛醇可减少经前烦躁，改善睡眠质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.