Effects of ubiquinol intake on improving menstrual symptoms among female healthcare workers: An open-label pilot study

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-03-27 DOI:10.1111/jog.16279

Tetsu Kinoshita, Koutatsu Maruyama, Kikumi Katakami, Takayo Sakiyama

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引用次数: 0

Abstract

Aim

This study aimed to investigate the effects of ubiquinol on menstrual symptoms.

Methods

This open-label trial involved 86 female healthcare workers aged 21–48 years. The study design included an observation period and a ubiquinol intake period. During the intake period, the participants consumed two soft capsules containing 75 mg of ubiquinol daily (i.e., 150 mg/day). At baseline and after the observation and intake periods, the participants underwent blood testing and completed the Pittsburgh Sleep Quality Index to evaluate their sleep condition. In addition, the Menstrual Distress Questionnaire was completed before, during, and after each of the first seven menses. All statistical analyses were performed, stratified by the median age of the participants.

Results

Regarding the Menstrual Distress Questionnaire, in the younger group (age: <36 years), a significant improvement was observed in menstrual “Control” (p = 0.049) by ubiquinol intake. In the older group (age: ≥36), the effects of ubiquinol on the improvement of premenstrual “Negative affect” and “Control” scores reached significance (p = 0.02 and p < 0.01, respectively); further, menstrual “Control” score was significantly improved (p = 0.03). In addition, the Pittsburgh Sleep Quality Index showed a significant effect of ubiquinol in the older group.

Conclusions

This pilot study indicated that ubiquinol alleviated menstrual symptoms among premenopausal female healthcare workers. In those aged ≥36 years, ubiquinol intake may reduce premenstrual irritability and improve sleep quality.

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.