Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Evaluation of Maternal Serum ELABELA Levels in Pregnancies Diagnosed With Abortus Imminens Between 8 and 14 Weeks of Gestation","authors":"Simge Özgedik,&nbsp;Metehan Hergüner,&nbsp;Alihan Duraçe,&nbsp;Çağdaş Necati Al,&nbsp;Ecem Yücel,&nbsp;Çağdaş Özgökçe,&nbsp;İbrahim Kale","doi":"10.1111/jog.70450","DOIUrl":"https://doi.org/10.1111/jog.70450","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Abortus imminens is a common condition in early pregnancy characterized by vaginal bleeding with a closed cervix and viable intrauterine pregnancy. Current biochemical markers have limited accuracy in predicting pregnancy outcomes. ELABELA (also known as Apela or Toddler), a peptide involved in angiogenesis and placental development, may serve as a potential biomarker in early pregnancy complications. This study aimed to evaluate maternal serum ELABELA levels in pregnancies diagnosed with abortus imminens.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective cross-sectional study included 45 pregnant women diagnosed with abortus imminens between 8 and 14 weeks of gestation and 45 healthy controls. Maternal serum ELABELA levels were measured using enzyme-linked immunosorbent assay (ELISA). All serum samples were analyzed simultaneously in a single analytical batch to minimize interassay variability. Statistical analyses included group comparisons, receiver operating characteristic (ROC) curve analysis, and binary logistic regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were no significant differences between groups in terms of age, body mass index (BMI), gestational age at sampling, gravidity, or parity (<i>p</i> &gt; 0.05). ELABELA levels were significantly lower in the abortus imminens group compared with controls (median: 649.82 vs. 859.60 pg/mL; <i>p</i> = 0.021). ROC analysis demonstrated modest discriminative ability (area under the curve [AUC] = 0.641; 95% confidence interval [CI]: 0.520–0.751), with an optimal cut-off value of 712.0 pg/mL (sensitivity 60.0%, specificity 68.9%). Logistic regression analysis showed no independent predictive value for ELABELA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Maternal serum ELABELA levels are significantly reduced in pregnancies with abortus imminens, suggesting a potential role in early placental dysfunction. Although ELABELA alone may not be a strong independent predictor, it may serve as a complementary biomarker in the evaluation of abortus imminens. Further large-scale prospective studies are needed to confirm these findings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 8","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental Senescence: An Emerging Target for Precision Obstetrics","authors":"Gunvanti Rathod,&nbsp;Pragnesh Parmar","doi":"10.1111/jog.70464","DOIUrl":"10.1111/jog.70464","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 8","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraplacental Choriocarcinoma Presenting With Postpartum Hemorrhage Requiring Uterine Artery Embolization: A Case Report","authors":"Shiori Tsuge,&nbsp;Kosuke Yoshida,&nbsp;Mari Shirasaki,&nbsp;Hiromi Nakamura,&nbsp;Kaoru Niimi,&nbsp;Hiroaki Kajiyama","doi":"10.1111/jog.70463","DOIUrl":"https://doi.org/10.1111/jog.70463","url":null,"abstract":"<div>\u0000 \u0000 <p>Intraplacental choriocarcinoma (ICC) is a rare gestational trophoblastic tumor that is often difficult to diagnose and is occasionally associated with fetomaternal hemorrhage (FMH). A 28-year-old woman presented with decreased fetal movements at 38 weeks of gestation. Due to a nonreassuring fetal heart rate pattern, an emergency cesarean section was performed. Severe neonatal anemia (3.2 g/dL) and markedly elevated maternal serum alpha-fetoprotein levels suggested FMH, despite normal maternal hemoglobin F levels. Initial placental pathology was unremarkable. Thirteen days postpartum, the patient developed massive vaginal bleeding requiring uterine artery embolization (UAE). Elevated serum β-hCG levels and multiple pulmonary nodules led to a clinical diagnosis of choriocarcinoma. Placental re-evaluation confirmed ICC. Chemotherapy with methotrexate, etoposide, and actinomycin D resulted in complete remission. In conclusion, ICC should be considered in cases of unexplained FMH or postpartum hemorrhage. UAE did not appear to impair the efficacy of subsequent chemotherapy in this case.</p>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 8","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal and Neurodevelopmental Outcomes Following Category 1 Cesarean Section in a Japanese Tertiary Perinatal Center","authors":"Yuka Sano Wada,&nbsp;Yuka Shibata,&nbsp;Sayaka Hayashi,&nbsp;Risa Arai,&nbsp;Masaki Sato,&nbsp;Yoko Yamashita,&nbsp;Nagayoshi Umehara,&nbsp;Yushi Ito,&nbsp;Tetsuya Isayama,&nbsp;Seiji Wada,&nbsp;Haruhiko Sago","doi":"10.1111/jog.70457","DOIUrl":"https://doi.org/10.1111/jog.70457","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To elucidate the neonatal and neurodevelopmental outcomes of infants born via Category 1 cesarean section (CS) in a Japanese tertiary perinatal center.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Infants born via Category 1 CS from 2015 to 2019 at the National Center for Child Health and Development were included. Neonatal outcomes, including intrapartum/infant death, cord blood pH, and Apgar scores, and neurodevelopmental outcomes assessed using the Kinder Infant Development Scale (KIDS) were examined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 101 children from 95 mothers were evaluated. The median decision-to-delivery interval (DDI) was 16 min. No intrapartum deaths occurred. Three children died during the neonatal period, whereas one died at 5 years of age. Among those who died, two had congenital diaphragmatic hernia, whereas two were preterm. The mean cord blood pH was 7.22; the median Apgar scores were 8 and 9, at 1 and 5 min, respectively. Among the 97 children aged 1 year 9 months to 6 years 5 months who received the KIDS questionnaire, 74 (76%) responded, with a median developmental quotient (DQ) of 110. Two children had a DQ below 70, one of whom had trisomy 21. Poor outcomes, including death and DQ below 70, appeared associated with severe congenital diseases or preterm birth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In this single-center cohort from a Japanese tertiary perinatal center operating in accordance with national guidelines and established emergency protocols, neonatal and neurodevelopmental outcomes were generally favorable among full-term infants without severe congenital disease who underwent Category 1 CS. Poor outcomes appeared to be related to fetal conditions including prematurity or anomalies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 8","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Observation of Abortion of Heterotopic Cesarean Scar Pregnancy: A Case Report With Literature Review","authors":"Tetsuro Shimada,&nbsp;Kenji Horie,&nbsp;Hirotada Suzuki,&nbsp;Manabu Ogoyama,&nbsp;Hironori Takahashi,&nbsp;Hiroyuki Fujiwara","doi":"10.1111/jog.70454","DOIUrl":"10.1111/jog.70454","url":null,"abstract":"<div>\u0000 \u0000 <p>Heterotopic cesarean scar pregnancy (HCSP) is a rare condition in which an intrauterine pregnancy coexists with an ectopic pregnancy implanted in a cesarean scar. Due to its rarity, no standardized management has been established. Here, we report a 38-year-old Japanese woman diagnosed with HCSP, who experienced massive bleeding associated with spontaneous abortion (SA) of the cesarean scar pregnancy (CSP) at 8 weeks of gestation. The coexisting intrauterine pregnancy remained viable. As she desired pregnancy continuation, she was managed expectantly. At 33^5/7 weeks, she developed massive bleeding leading to hemorrhagic shock, necessitating emergency cesarean section. Bilateral uterine artery embolization was performed postoperatively to achieve hemostasis. Both the mother and her baby were discharged uneventfully. Although expectant management following SA of CSP in a dichorionic twin pregnancy may permit survival of the co-twin, pregnancy continuation carries a persistent risk of sudden-onset heavy bleeding. Active intervention for CSP in HCSP may improve perinatal outcomes.</p>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 8","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative Management and Outcomes of Preoperatively Diagnosed Venous Thromboembolism in Gynecological Surgery: A Multicenter Retrospective Study Based on 2020–2022 Data From the Japanese Society of Anesthesiologists","authors":"Ryuji Kawaguchi,&nbsp;Motoi Sugimura,&nbsp;Reiko Neki,&nbsp;Yugo Yamashita,&nbsp;Kenichi Masui,&nbsp;Chikashi Takeda,&nbsp;Pulmonary Embolism Working Group of the Japanese Society of Anesthesiologists","doi":"10.1111/jog.70452","DOIUrl":"https://doi.org/10.1111/jog.70452","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Patients with preoperatively diagnosed venous thromboembolism (VTE) present complex management challenges, and optimal strategies for gynecological surgery remain unclear. Because malignancy is a major risk factor for VTE, perioperative management and outcomes may differ between malignant and benign gynecological diseases. This study aimed to compare perioperative management and short-term outcomes between these groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective observational study included 1406 patients with preoperatively diagnosed VTE undergoing gynecological surgery between 2020 and 2022 using the Japanese Society of Anesthesiologists database. Patients were divided into malignant (M-group, <i>n</i> = 1126) and benign (B-group, <i>n</i> = 280) groups. Clinical characteristics, treatment strategies, and postoperative outcomes within 28 days after surgery were compared.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 1406 patients, 421 (29.9%) had pulmonary embolism, 161 (11.5%) had proximal deep vein thrombosis (DVT), and 824 (58.6%) had distal DVT. Direct oral anticoagulants were the most commonly used preoperative anticoagulants (61.3%), followed by unfractionated heparin (24.8%). Postoperative anticoagulation was more frequent in the M-group than in the B-group (57.5% vs. 44.6%; <i>p</i> &lt; 0.001). The 28-day all-cause mortality (1.2% vs. 0.7%; <i>p</i> = 0.752), VTE recurrence (2.0% vs. 2.9%; <i>p</i> = 0.406), and major bleeding (1.1%; <i>p</i> = 0.220) were comparable between groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study provides real-world data on perioperative management and short-term outcomes in gynecological surgical patients with preoperatively diagnosed VTE in Japan. Prospective studies are required to establish optimal, risk-stratified perioperative management strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 8","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes Associated With Methotrexate Use in Conservatively Managed Placenta Accreta Spectrum: A Retrospective Comparative Study","authors":"Shizuki Daiho,&nbsp;Yutaka Iwagoi,&nbsp;Akihito Sagara,&nbsp;Risa Shimokawa,&nbsp;Saori Yoshimura,&nbsp;Masaru Kobayashi,&nbsp;Miyuki Ochiai,&nbsp;Yasuhiro Yamamoto,&nbsp;Munekage Yamaguchi,&nbsp;Haruta Mogami,&nbsp;Eiji Kondoh","doi":"10.1111/jog.70447","DOIUrl":"https://doi.org/10.1111/jog.70447","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Conservative management with the placenta left in situ has emerged as an alternative approach for placenta accreta spectrum (PAS). Methotrexate (MTX) is sometimes used to facilitate placental resorption; however, its clinical benefit remains uncertain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective cohort study at two tertiary centers including patients with PAS managed conservatively with the placenta left in situ after cesarean delivery between April 2011 and March 2026. Patients were divided into MTX and non-MTX groups. The primary outcome was a composite adverse outcome, defined as cytopenia, bloodstream infection (BSI), late postpartum hypofibrinogenemia (LPH), therapeutic uterine artery embolization (UAE), or delayed hysterectomy. Secondary outcomes included suspected intrauterine infection and time to serum human chorionic gonadotropin (hCG) normalization.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seventeen patients were included (MTX, <i>n</i> = 8; non-MTX, <i>n</i> = 9). The composite adverse outcome occurred in 50.0% of patients in the MTX group and 44.4% in the non-MTX group, with no significant difference (RR 1.13, 95% CI 0.40–3.10; <i>p</i> = 1.00). Cytopenia was observed only in the MTX group (37.5% vs. 0%; <i>p</i> = 0.08). Other outcomes, including BSI, LPH, UAE, hysterectomy, and suspected intrauterine infection, were similar between groups. The median time to hCG normalization did not differ significantly between groups (66.5 vs. 64.0 days; <i>p</i> = 0.76).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>MTX use in conservatively managed PAS was not associated with improved clinical outcomes and may be associated with increased hematologic toxicity. These findings suggest that routine MTX administration does not appear to provide clinical benefit and may increase toxicity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 8","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ophthalmic Artery Doppler Indices and Maternal Factors in the Prediction of Preeclampsia in a High-Risk Obstetric Population: A Prospective Cohort Study","authors":"Giselle Odette Noyola-Landázuri,&nbsp;Francisco Javier Castro-Apodaca,&nbsp;Ramón Jafit González-López,&nbsp;Víctor Manuel Martínez-Vera,&nbsp;Gloria María Peña-García,&nbsp;Nidia Leon-Sicairos,&nbsp;Adrian Canizalez-Roman","doi":"10.1111/jog.70449","DOIUrl":"10.1111/jog.70449","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the utility of ophthalmic artery Doppler (OAD) indices, combined with maternal clinical factors, mean arterial pressure (MAP), and uterine artery pulsatility index (UtA-PI), for the prediction of preeclampsia (PE) in a high-risk obstetric population at 18–24 weeks of gestation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Prospective cohort study conducted at a tertiary referral unit (UMAE HGO–CMNO, IMSS, Guadalajara, Mexico) from January to December 2025. Singleton pregnancies with at least one major or two minor PE risk factors per NICE/ACOG guidelines were included. Assessments comprised MAP (bilateral brachial), UtA-PI (transabdominal Doppler), and OAD quantified as the second-to-first peak systolic velocity ratio (R-PSV_1–2) via convex transducer over the right eye; R-PSV_1–2 &gt; 0.60 was defined as abnormal. Hierarchical logistic regression models and ROC analysis were constructed; significance was set at <i>p</i> &lt; 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 182 women included, 81 had abnormal OAD and 101 had normal OAD. Overall, PE occurred in 24 (13.2%): 20/81 (24.7%) in the abnormal group versus 4/101 (4.0%) in the normal group (OR 7.95, 95% CI 2.59–24.38; <i>p</i> &lt; 0.001). All 16 early-onset PE cases (&lt; 34 weeks) arose exclusively in the abnormal OAD group (sensitivity 100%, NPV 100%). The full model (clinical + MAP + UtA-PI + OAD) achieved an AUC of 0.815 (95% CI 0.698–0.909), superior to the clinical-only model (AUC 0.722). In multivariable analysis, abnormal OAD was the strongest independent predictor (adjusted OR, 6.49; 95% CI 1.91–22.03; <i>p</i> = 0.003).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>OAD at 18–24 weeks significantly improves PE prediction in high-risk pregnancies beyond conventional risk factors. Its perfect sensitivity and NPV for early-onset PE support its integration into multiparametric second-trimester screening protocols.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 8","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Labor Induction Versus Expectant Management—A Scoping Review of Randomized Controlled Trial Evidence","authors":"Premanjali Chowdhury,&nbsp;Ilari Kuitunen","doi":"10.1111/jog.70445","DOIUrl":"10.1111/jog.70445","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Induction of labor is increasingly used across diverse obstetric indications, yet uncertainty persists regarding its impact on neonatal outcomes compared with expectant management across gestational ages. This scoping review aimed to map the scope, characteristics, and findings of randomized controlled trial (RCT) evidence comparing induction of labor with expectant management in singleton pregnancies, with particular emphasis on neonatal outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>PubMed, Scopus, and Web of Science were searched in March 2025. Eligible studies were parallel-group RCTs comparing induction of labor with expectant management involving at least 24 h of planned delay in singleton pregnancies. Trials addressing any gestational age or clinical indication were included. Findings were synthesized descriptively by clinical indication.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty RCTs published between 1987 and 2023 were included. Indications comprised post-term pregnancy, prelabor rupture of membranes, hypertensive disorders, suspected macrosomia, elective induction at term, and preterm medical conditions. Neonatal outcomes were heterogeneously reported, most commonly NICU admission and perinatal mortality. Across indications, trials generally showed similar or improved neonatal outcomes with induction compared with expectant management in term and post-term settings, alongside comparable or reduced cesarean delivery rates. In hypertensive and preterm conditions, neonatal outcomes varied by gestational age, with higher NICU admissions reflecting prematurity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This scoping review maps RCT evidence suggesting that induction is not associated with worse neonatal outcomes across most indications. Effects are context-specific and gestational age-dependent, with important trade-offs in preterm settings. Substantial heterogeneity and evidence gaps highlight the need for standardized outcomes and further research.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 8","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.70445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Reduction of an Incarcerated Gravid Uterus With a Giant Uterine Fibroid in Late Pregnancy: A Case Report","authors":"Taishin Kido,&nbsp;Ken Takahashi,&nbsp;Miyu Yoshida,&nbsp;Hiromitsu Azuma,&nbsp;Nagayoshi Umehara,&nbsp;Seiji Wada","doi":"10.1111/jog.70459","DOIUrl":"10.1111/jog.70459","url":null,"abstract":"<div>\u0000 \u0000 <p>Incarceration of the gravid uterus is a rare obstetric complication causing serious maternal and fetal morbidity. This report describes the case of a 43-year-old gravida 3, para 0 woman with a giant uterine fibroid who was diagnosed with an incarcerated gravid uterus at 24 gestational weeks based on transvaginal ultrasonography and magnetic resonance imaging (MRI). The largest fibroid measured 15 cm in maximum diameter and was thought to limit uterine mobility; therefore, conservative management with a planned cesarean delivery was selected. Repeat MRI at 34 weeks unexpectedly demonstrated spontaneous reduction of the incarcerated uterus, with the cervix restored to its normal caudal position. Hence, delivery planning and surgical strategy were revised based on updated anatomical findings. Emergency cesarean delivery was successfully performed at 36 weeks, without recurrence of uterine incarceration. Continuous anatomical reassessment throughout pregnancy, including the third trimester, is essential for optimizing peripartum management and avoiding preventable complications.</p>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 8","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}