Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Sertoli cell tumor associated with ovarian sex cord tumor with annular tubules in a patient with 46 XY disorder of sex development and 9p24.3 deletion, case report","authors":"Tabatha Petrillo,&nbsp;Christian Battipaglia,&nbsp;Elisa Semprini,&nbsp;Cinzia Baldessari,&nbsp;Marta Pirola,&nbsp;Olga Calabrese,&nbsp;Antonino Farulla,&nbsp;Giliana Ternelli,&nbsp;Albino Eccher,&nbsp;Laura Botticelli,&nbsp;Alessandro D. Genazzani","doi":"10.1111/jog.70027","DOIUrl":"10.1111/jog.70027","url":null,"abstract":"<p>We report a rare case involving a 22-year-old phenotypically female patient who presented to our care with primary amenorrhea and spontaneous breast development. Hormonal analysis indicated hypergonadotropic hypogonadism, and imaging revealed a hypoplastic uterus and calcified ovaries. Karyotyping was 46, XY and the presence of the <i>SRY</i> gene was confirmed. The patient underwent laparoscopic bilateral salpingo-oophorectomy due to the high risk of malignancy development. Histopathological analysis revealed bilateral Sertoli cell tumors and a sex cord tumor with annular tubules in the right gonad. Next generation sequencing genetic testing identified a 1.24 Mb deletion on chromosome 9p24.3, which included the DMRT1, DMRT2, and DMRT3 genes, as well as a partial deletion of KANK1. Hormonal replacement therapy was not initiated due to the potential risk of tumor recurrence, and follow-up imaging was scheduled every 6 months for the first 2 years and then annually. No recurrence was observed at 24 months.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.70027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates and advances for gynecologic imaging","authors":"Kazuhiro Kitajima","doi":"10.1111/jog.70025","DOIUrl":"10.1111/jog.70025","url":null,"abstract":"<p>A gynecologic malignancy is one of the most common cancers affecting females and is responsible for significant rates of morbidity and mortality throughout the world. Early discovery and accurate staging, as well as early recurrence detection and correct assessment of therapeutic response, are important factors for patient management and survival. For detection and characterization, as well as staging and restaging of gynecologic conditions most commonly encountered, that is, cervical, endometrial, and ovarian malignancy, the usage of ultrasound, analysis of images obtained with computed tomography (CT), magnetic resonance imaging, and positron emission tomography–CT has critical roles. Recently, artificial intelligence used to extract quantitative information from radiological imaging has become an important factor for treatment decisions. The present review article provides important information related to recent advances in gynecologic malignancy imaging options, with a focus on findings related to cervical, endometrial, and ovarian neoplasms.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.70025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of patients with mesh or sling exposure: A single-center retrospective study","authors":"Xiaohui Sun,&nbsp;Yuancui Xiang,&nbsp;Shiyan Wang,&nbsp;Xiuli Sun","doi":"10.1111/jog.70018","DOIUrl":"10.1111/jog.70018","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aims to (1) summarize the chief complaints related to mesh exposure, offering insights for clinical identification; (2) detail the clinical characteristics of mesh exposure using the category-time-section (CTS) system; and (3) describe the management and outcomes of mesh exposure to offer evidence for guidance and share opinions for other surgeons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a single-center retrospective study. We analyzed data of mesh or sling exposure patients clinically collected by our hospital from January 2008 to January 2020. Analysis was performed on the basic information, primary operation for pelvic organ prolapse or stress urinary incontinence, chief complaint, CTS classification, treatment, and outcome for mesh or sling exposure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 71 women were included in this study, whose median age was 56 years. Twenty-five of those patients (35.21%) underwent transvaginal mesh (TVM) for POP. The most common chief complaint was vaginal bleeding (40/71, 56.34%). Category 2 (49.30%) and category 3 (46.48%) were the predominant CTS categories. The majority of those patients were identified to have mesh exposures in 12 months post-surgery. Thirty-nine patients (54.93%) underwent multiple procedures to address mesh or sling exposure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Vaginal bleeding and pain can be indicative symptoms for mesh exposure. Mesh or sling exposure initiates most frequently in 12 months post-surgery and localizes predominantly at the vaginal suture area. Non-surgical approaches can be adopted as initial preservative treatment for patients who are asymptomatic and have exposure smaller than 1 cm².</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of hepatitis C virus infection with risk of gestational diabetes mellitus: A systematic review and meta-analysis","authors":"Qingyun Liu,&nbsp;Fang Liu,&nbsp;Yuefeng Xia,&nbsp;Shanshan Wei","doi":"10.1111/jog.70015","DOIUrl":"10.1111/jog.70015","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Whether hepatitis C virus (HCV) infection is associated with the risk of gestational diabetes mellitus (GDM) remains controversial. This study aims to systematically evaluate the impact of HCV infection on GDM risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Seven electronic databases, including PubMed, Embase, Web of Science, Ovid, ScienceDirect, China National Knowledge Infrastructure, and SinoMed, were retrieved for all related studies by October of 2024. Studies on the relationship between HCV infection and GDM risk were included. The quality of included studies was assessed using the Newcastle-Ottawa Scale. A random effects meta-analysis was performed to estimate the overall odds ratio (OR) and 95% confidence intervals (CI) by Stata software.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The analysis included 18 studies comprising 45 567 678 pregnancies. HCV infection was significantly associated with increased GDM risk (pooled OR = 1.21, 95% CI: 1.04–1.40), with substantial heterogeneity (<i>I</i>² = 87.6%). Subgroup analyses demonstrated significant associations in European populations (OR = 1.66, 95% CI: 1.13–2.43; <i>I</i>² = 40.4%), prospective cohort studies (OR = 1.72, 95% CI: 1.33–2.22; <i>I</i>² = 0.0%), human immunodeficiency virus-positive populations (OR = 2.04, 95% CI: 1.04–3.99; <i>I</i>² = 46.2%), and general populations (OR = 1.16, 95% CI: 1.00–1.34; <i>I</i>² = 88.7%). There was a positive but not statistically significant association for the North America population and retrospective studies (<i>p</i> &lt; 0.05), with considerable heterogeneity. The overall results were robust, indicated by sensitivity analysis, and no obvious publication bias was observed according to Begg's test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>HCV infection is positively associated with increased GDM risk. Further studies with diverse representative populations and more rigorous prospective designs are warranted to establish more comprehensive conclusions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive Endocrinology Committee, Japan Society of Obstetrics and Gynecology: Annual report 2023–2024","authors":"Akira Iwase,&nbsp;Yoshikazu Kitahara,&nbsp;Hiroshi Ishikawa,&nbsp;Hidetaka Okada,&nbsp;Yukiko Katagiri,&nbsp;Kazuhiro Kawamura,&nbsp;Fuminori Kimura,&nbsp;Toshifumi Takahashi,&nbsp;Yukihiro Terada,&nbsp;Osamu Hiraike,&nbsp;Yasushi Hirota,&nbsp;Atsushi Fukui,&nbsp;Mitsutoshi Yamada,&nbsp;Satoko Osuka,&nbsp;Seung Chik Jwa,&nbsp;Fuminori Taniguchi","doi":"10.1111/jog.70008","DOIUrl":"10.1111/jog.70008","url":null,"abstract":"<p>Since 2005, the Reproductive Endocrinology Committee of the Japan Society of Obstetrics and Gynecology has conducted research and provided recommendations for reproductive medicine and endocrinology. This report summarizes the activities of eight subcommittees over 2 years, from 2023 to 2024. These subcommittees addressed various topics, including the review of medical and social indications for oocyte cryopreservation, the current status and challenges of embryo cryopreservation and disposal, the investigation of ovulatory disorders through the HyPO-P classification and a nationwide survey of young women with suspected polycystic ovary syndrome, the revision of polycystic ovary syndrome diagnostic criteria and the development of updated treatment guidelines, the survey of adoption rates of in vitro fertilization add-on treatments following insurance coverage, the national survey on the diagnosis and management of diffuse uterine leiomyomatosis and hereditary leiomyomatosis and renal cell carcinoma, the establishment of a clinical registry system for adenomyomectomy cases, the management of subclinical hypothyroidism in patients with infertility, and the promotion of effective utilization of assisted reproductive technology registry data in Japan. Each subcommittee provides valuable insights into the current status of reproductive medicine in Japan, identifies key challenges, and proposes recommendations to support clinical practice and guideline development. This report will serve as a foundation for advancing reproductive medicine and ensuring high-quality patient care in Japan.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The magnitude and distribution of pressure of obstetric forceps on a fetal head mannequin model","authors":"Alfredo Gei,&nbsp;Kim Hennan,&nbsp;Victor Suarez,&nbsp;Rafaela Germano Toledo,&nbsp;Julia Molisani,&nbsp;Nathalia Martinez","doi":"10.1111/jog.16363","DOIUrl":"10.1111/jog.16363","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Considerations for forceps specific shape and dimensions are usually not available for review. This study evaluates surfaces of contact, magnitude of force, and pressure distribution of different forceps on a fetal head model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Pressure-sensitive films were cut following planar impressions of commonly used forceps. After biparieto-bimalar applications on a term fetal head model, the films were scanned and areas of contact, pressure, and force calculated. Comparisons were made between different types of film and forceps. Significance was considered if <i>p</i> &lt; 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty-four forceps impressions were analyzed. With decreasing film sensitivities, smaller contact areas (<i>p</i> &lt; 0.01) and higher mean pressures (<i>p</i> &lt; 0.01) were detected. No significant differences were noted between different forceps regarding contact areas, pressure, or force. Most impressions reveal pressure points in the range of 980–1400 psi.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Ergonomic improvements can be made to the design of forceps blades in order to improve maternal-fetal morbidity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic impact of neoadjuvant chemotherapy on lymph node metastasis in locally advanced cervical cancer","authors":"Yuka Mizuta,&nbsp;Koji Yamanoi,&nbsp;Taito Miyamoto,&nbsp;Rin Mizuno,&nbsp;Mana Taki,&nbsp;Ryusuke Murakami,&nbsp;Yuki Himoto,&nbsp;Ken Yamaguchi,&nbsp;Junzo Hamanishi,&nbsp;Masaki Mandai","doi":"10.1111/jog.70022","DOIUrl":"10.1111/jog.70022","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cervical cancer remains a global health concern. Lymph node (LN) metastasis, especially para-aortic LN (PAN) involvement, is a critical prognostic factor. While neoadjuvant chemotherapy (NAC) followed by radical hysterectomy (RH) is used for locally advanced cervical cancer, its therapeutic effect on LN metastases remains uncertain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This retrospective study analyzed 110 patients treated with NAC followed by RH. Patients were grouped into nine cIIIC2 cases with PAN metastasis, 81 non-cIIIC2 squamous cell carcinoma (SCC) cases, and 20 non-squamous cell carcinoma (non-SCC) cases. Non-cIIIC2 SCC cases were further divided into four subgroups by LN status: cN1ypN1 (<i>n</i> = 16), cN1ypN0 (<i>n</i> = 24), cN0ypN1 (<i>n</i> = 10), and cN0ypN0 (<i>n</i> = 31). Tumor and LN size changes by NAC and survival outcomes were analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In cIIIC2 cases, ypPAN-negative patients showed significantly better 5-year progression-free survival (PFS) compared to ypPAN-positive cases (100% vs. 0%, <i>p</i> &lt; 0.0001). Among non-SCC cases, ypN1 patients (<i>n</i> = 9) had poorer outcomes than ypN0 cases (<i>n</i> = 11) (5-year PFS: 25% vs. 90%, <i>p</i> = 0.0005). As for non-cIIIC2 SCC cases, tumor shrinkage rates varied among SCC subgroups: cN0ypN0 (−58.3%), cN1ypN0 (−45.5%), cN1ypN1 (−36.4%), and cN0ypN1 (−29.6%). cN0ypN1 cases also showed distinct recurrence patterns, with 66.7% experiencing distant metastases; however, prognosis did not differ among four LN-related groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>NAC can significantly improve prognosis in selected cases where LN metastases are eliminated, particularly in PAN and non-SCC pelvic region metastasis cases. However, such cases are rare, emphasizing the need for better candidate selection and enhanced treatment strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144716889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hysterectomy for postpartum hemorrhage in Japan: Diagnostic code validation and nationwide descriptive analysis","authors":"Eishin Nakamura,&nbsp;Tadahiro Goto,&nbsp;Shigetaka Matsunaga,&nbsp;Akihiko Kikuchi,&nbsp;Yasushi Takai,&nbsp;Sayuri Shimizu","doi":"10.1111/jog.70019","DOIUrl":"10.1111/jog.70019","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Hysterectomy is a life-saving procedure for severe postpartum hemorrhage (PPH), but reports on postoperative mortality are limited. This study aimed to describe the rates of hysterectomy and associated mortality in PPH patients using the Diagnosis Procedure Combination (DPC) database, Japan's largest inpatient database.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>We first validated the accuracy of PPH diagnostic coding at a tertiary perinatal center, then conducted a nationwide descriptive analysis using DPC data from April 2018 to March 2023. The DPC database includes over half of all acute care hospital admissions in Japan. PPH cases were identified using International Statistical Classification of Diseases and Related Health Problems, 10th Revision codes and blood loss data. We examined hysterectomy rates and postoperative mortality, including a subgroup excluding cases with conditions requiring planned hysterectomy during cesarean section (e.g., placenta previa, accreta, uterine rupture, and cervical cancer).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The validation study showed high accuracy of PPH coding, with a sensitivity of 97.8% and specificity of 99.7%. Among 209 555 PPH cases, 1835 (0.88%) underwent hysterectomy, with a mortality rate of 0.87% (16 deaths). After excluding 23 039 cases with indications for planned hysterectomy, 681 of 186 516 cases (0.36%) required hysterectomy, with a higher mortality rate of 2.2%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The DPC database reliably identifies PPH cases. Hysterectomy was performed in 0.88% of all PPH cases, with higher mortality in emergency cases after excluding planned procedures.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144716612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking informed consent: Is telling all always necessary?","authors":"Shigeki Matsubara","doi":"10.1111/jog.70023","DOIUrl":"10.1111/jog.70023","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early prediction of preeclampsia using first-trimester maternal serum levels of vasohibin-1, cardiotropin-1, and endocan","authors":"İbrahim Kale,&nbsp;Ayşe Keleş,&nbsp;Merve Dizdar,&nbsp;Simge Pesen,&nbsp;Berat Berrin Gençoğlu Bakbak,&nbsp;Aybike Kaya,&nbsp;Ayşegül Özel","doi":"10.1111/jog.70012","DOIUrl":"10.1111/jog.70012","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To explore the potential role of first-trimester serum levels of vasohibin-1, cardiotropin-1, and endocan in predicting the development of preeclampsia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this prospective case–control study, blood samples were collected from 1054 pregnant women during the first-trimester screening test. The preeclampsia group consisted of 43 pregnant women who developed preeclampsia, while the control group included 129 pregnant women selected from a pool of 777 women whose pregnancies progressed without complications. The selection of controls was performed using the SPSS program at a 1:3 ratio (one case to three controls). Levels of vasohibin-1, cardiotropin-1, and endocan in the samples were measured using the ELISA method with commercial kits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>While serum levels of cardiotropin-1 and endocan did not differ between the preeclampsia and control groups, serum vasohibin-1 levels were significantly higher in the preeclampsia group (<i>p</i> = 0.301, <i>p</i> = 0.066, <i>p</i> = 0.010, respectively). In the ROC analysis conducted to determine the cut-off value of first-trimester serum vasohibin-1 in predicting preeclampsia (AUC: 0.631, 95% CI = 0.53–0.72), the optimal cut-off value for vasohibin-1 was identified as 1314.73 pg/mL, with a sensitivity of 60% and a specificity of 60%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Although serum vasohibin-1 levels in the first trimester demonstrated low sensitivity and specificity for the early prediction of preeclampsia, our results indicate that elevated first-trimester vasohibin-1 levels may be linked to the subsequent onset of preeclampsia. Additionally, our findings suggest that first-trimester serum levels of cardiotropin-1 and endocan are not reliable markers for predicting the development of preeclampsia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}