Melek Aydin, Nebahat Çağlayan, Özlem Kara, Mustafa Kara
{"title":"硼酸对内毒素血症致卵巢损伤的保护作用","authors":"Melek Aydin, Nebahat Çağlayan, Özlem Kara, Mustafa Kara","doi":"10.1111/jog.70055","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>Sepsis is a serious reaction of the whole body to an infection that develops in the presence of bacteria or toxins in the body. Boric acid (BA) is the most common mineral acid among boron compounds and is easily soluble in water. BA has antioxidant and anti-inflammatory properties. In line with this information, in our study, the protective effect of BA was examined by creating sepsis with lipopolysaccharide (LPS), a bacterial endotoxin.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>In our study, 32 Wistar Albino female rats were used and divided into four groups. The protective effect of BA on ovarian histopathology and ovarian functions as a result of endotoxaemia was investigated.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>As a result of the examinations, follicle counts were evaluated in the groups. As a result, it was found that fibrosis occurred in the cortex vessels in the ovary of rats given LPS, follicle loss occurred, and ovarian tissue scarring caused toxicity on primordial follicles. The number of primordial follicles in the LPS group was significantly lower than in the BA + LPS group (<i>p</i> < 0.05). Contrary to this, the number of atretic follicles was found to be significantly higher in the LPS group than in the BA + LPS group (<i>p</i> < 0.05).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>In this study, it was concluded that BA had a protective effect on the ovarian damage caused by endotoxaemia induced by LPS.</p>\n </section>\n </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 8","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Protective effect of boric acid on ovarian damage caused by endotoxaemia\",\"authors\":\"Melek Aydin, Nebahat Çağlayan, Özlem Kara, Mustafa Kara\",\"doi\":\"10.1111/jog.70055\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>Sepsis is a serious reaction of the whole body to an infection that develops in the presence of bacteria or toxins in the body. Boric acid (BA) is the most common mineral acid among boron compounds and is easily soluble in water. BA has antioxidant and anti-inflammatory properties. In line with this information, in our study, the protective effect of BA was examined by creating sepsis with lipopolysaccharide (LPS), a bacterial endotoxin.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Materials and Methods</h3>\\n \\n <p>In our study, 32 Wistar Albino female rats were used and divided into four groups. The protective effect of BA on ovarian histopathology and ovarian functions as a result of endotoxaemia was investigated.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>As a result of the examinations, follicle counts were evaluated in the groups. As a result, it was found that fibrosis occurred in the cortex vessels in the ovary of rats given LPS, follicle loss occurred, and ovarian tissue scarring caused toxicity on primordial follicles. The number of primordial follicles in the LPS group was significantly lower than in the BA + LPS group (<i>p</i> < 0.05). Contrary to this, the number of atretic follicles was found to be significantly higher in the LPS group than in the BA + LPS group (<i>p</i> < 0.05).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>In this study, it was concluded that BA had a protective effect on the ovarian damage caused by endotoxaemia induced by LPS.</p>\\n </section>\\n </div>\",\"PeriodicalId\":16593,\"journal\":{\"name\":\"Journal of Obstetrics and Gynaecology Research\",\"volume\":\"51 8\",\"pages\":\"\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-08-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Obstetrics and Gynaecology Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://obgyn.onlinelibrary.wiley.com/doi/10.1111/jog.70055\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Obstetrics and Gynaecology Research","FirstCategoryId":"3","ListUrlMain":"https://obgyn.onlinelibrary.wiley.com/doi/10.1111/jog.70055","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Protective effect of boric acid on ovarian damage caused by endotoxaemia
Objective
Sepsis is a serious reaction of the whole body to an infection that develops in the presence of bacteria or toxins in the body. Boric acid (BA) is the most common mineral acid among boron compounds and is easily soluble in water. BA has antioxidant and anti-inflammatory properties. In line with this information, in our study, the protective effect of BA was examined by creating sepsis with lipopolysaccharide (LPS), a bacterial endotoxin.
Materials and Methods
In our study, 32 Wistar Albino female rats were used and divided into four groups. The protective effect of BA on ovarian histopathology and ovarian functions as a result of endotoxaemia was investigated.
Results
As a result of the examinations, follicle counts were evaluated in the groups. As a result, it was found that fibrosis occurred in the cortex vessels in the ovary of rats given LPS, follicle loss occurred, and ovarian tissue scarring caused toxicity on primordial follicles. The number of primordial follicles in the LPS group was significantly lower than in the BA + LPS group (p < 0.05). Contrary to this, the number of atretic follicles was found to be significantly higher in the LPS group than in the BA + LPS group (p < 0.05).
Conclusion
In this study, it was concluded that BA had a protective effect on the ovarian damage caused by endotoxaemia induced by LPS.
期刊介绍：
The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology.
The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.
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