Protective effect of boric acid on ovarian damage caused by endotoxaemia

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-08-25 DOI:10.1111/jog.70055

Melek Aydin, Nebahat Çağlayan, Özlem Kara, Mustafa Kara

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引用次数: 0

Abstract

Objective

Sepsis is a serious reaction of the whole body to an infection that develops in the presence of bacteria or toxins in the body. Boric acid (BA) is the most common mineral acid among boron compounds and is easily soluble in water. BA has antioxidant and anti-inflammatory properties. In line with this information, in our study, the protective effect of BA was examined by creating sepsis with lipopolysaccharide (LPS), a bacterial endotoxin.

Materials and Methods

In our study, 32 Wistar Albino female rats were used and divided into four groups. The protective effect of BA on ovarian histopathology and ovarian functions as a result of endotoxaemia was investigated.

Results

As a result of the examinations, follicle counts were evaluated in the groups. As a result, it was found that fibrosis occurred in the cortex vessels in the ovary of rats given LPS, follicle loss occurred, and ovarian tissue scarring caused toxicity on primordial follicles. The number of primordial follicles in the LPS group was significantly lower than in the BA + LPS group (p < 0.05). Contrary to this, the number of atretic follicles was found to be significantly higher in the LPS group than in the BA + LPS group (p < 0.05).

Conclusion

In this study, it was concluded that BA had a protective effect on the ovarian damage caused by endotoxaemia induced by LPS.

Abstract Image

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硼酸对内毒素血症致卵巢损伤的保护作用

目的脓毒症是在体内存在细菌或毒素的情况下，整个身体对感染的严重反应。硼酸（BA）是硼化合物中最常见的无机酸，易溶于水。BA具有抗氧化和抗炎特性。根据这一信息，在我们的研究中，通过使用脂多糖（LPS）（一种细菌内毒素）产生脓毒症来检测BA的保护作用。材料与方法选用Wistar白化雌性大鼠32只，分为4组。研究了BA对内毒素血症所致卵巢组织病理学和卵巢功能的保护作用。结果根据检查结果，对各组卵泡计数进行评估。结果发现，给予LPS的大鼠卵巢皮质血管发生纤维化，卵泡丢失，卵巢组织瘢痕形成对原始卵泡产生毒性。LPS组原始卵泡数量显著低于BA + LPS组（p < 0.05）。与此相反，LPS组闭锁卵泡数量明显高于BA + LPS组（p < 0.05）。结论BA对内毒素血症致卵巢损伤有保护作用。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.