Journal of Nutrition and Metabolism最新文献

{"title":"Muscle-Bone Relationship: Positive Association Between Appendicular Skeletal Muscle Mass and Bone Microarchitecture in Postmenopausal Women.","authors":"Camila Vilarinho Vidigal, Patrícia Paula da Fonseca Grili, Geise Ferreira da Cruz, Ben-Hur Albergaria, Luciane Daniele Cardoso, José Luiz Marques-Rocha, Valdete Regina Guandalini","doi":"10.1155/jnme/3170619","DOIUrl":"10.1155/jnme/3170619","url":null,"abstract":"<p><strong>Background: </strong>Low estrogen levels affect bone mineral density and bone microarchitecture, increasing the risk of osteoporosis. This hormonal change can also contribute to the loss of strength, muscle mass, and physical performance.</p><p><strong>Aim: </strong>To investigate associations between the components of sarcopenia and bone microarchitecture in postmenopausal women.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with 98 women ≥ 50 years of age. Data were collected on sociodemographic, lifestyle, and clinical characteristics. Measurements were performed of height, body mass, calf circumference adjusted for BMI, grip strength, and physical performance using the Timed Up and Go test. The appendicular skeletal muscle mass index (ASMI) and bone mineral density were estimated by dual energy X-ray absorptiometry. Bone microarchitecture was determined by the trabecular bone score. The association between ASMI and bone microarchitecture was tested using multivariate linear regression analysis with adjusted models.</p><p><strong>Results: </strong>The participants were predominantly between 60.0 and 69.9 years of age (62.3%), lived with a partner (51.0%), declared themselves to be non-White (59.2%), had low or no education (67.3%), were sufficiently active (52.0%), and did not consume alcohol (87.8%) or smoke (94.9%). ASMI was associated with bone microarchitecture after the adjustment of the models (<i>β</i> = 0.047; 95% CI: 0.009-0.084; <i>p</i> = 0.015).</p><p><strong>Conclusion: </strong>The positive association found between skeletal muscle mass and bone microarchitecture indicates that maintaining muscle mass may play a significant role in bone health among postmenopausal women.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2025 ","pages":"3170619"},"PeriodicalIF":2.4,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12664717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the University Students' Knowledge, Attitudes, and Use of Protein Supplements: A Cross-Sectional Study From the United Arab Emirates.","authors":"Taima Qudah, Sehar Iqbal, Hamza Al Absi, Sayed Sanal, Aya Elkoumi, Leen Fino, Suhad Abumweis","doi":"10.1155/jnme/5582105","DOIUrl":"10.1155/jnme/5582105","url":null,"abstract":"<p><strong>Background: </strong>Dietary supplements are widely used by athletes and sportspersons; however, little is known about protein supplement intake among university students undertaking strength training in gyms in the United Arab Emirates (UAE).</p><p><strong>Purpose: </strong>The purpose of this study was to examine the consumption, knowledge, perceptions, and use of protein supplementation, alone or in association with other supplements, among university students attending fitness centers in the UAE.</p><p><strong>Method: </strong>A cross-sectional study was conducted among university students in the UAE using a previously validated, self-administered online survey.</p><p><strong>Result: </strong>A total of 402 adults participated in the study. Approximately 260 (64%) of the participants visited fitness centers, with a higher percentage of males (154/207, 74.4%) than females (106/195, 54.4%). Those who frequented gyms consumed more protein supplements (91/260, 35.0%) compared with nonattendees (8/142, 5.6%). Significant gender differences were observed regarding the benefits and risks of protein supplementation. Among all the participants, 123 (31%) thought that the greatest benefit was building muscle mass, while 141 (35%) believed there was no risk involved. Among protein supplement users, 65 of 109 (59.6%) experienced some type of side effect. Additionally, 57 (14.2%) reported that friends or family encouraged them to take protein supplements.</p><p><strong>Conclusion: </strong>There is an urgent need to educate university students about the responsible use of protein supplements and the potential risks associated with their misuse. This can be achieved by providing reliable information through university health centers, academic tutors, nutritionists, and awareness campaigns conducted by student wellness services.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2025 ","pages":"5582105"},"PeriodicalIF":2.4,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12662688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Dietary Intake of Aromatic Amino Acids and Metabolic Syndrome.","authors":"Mahshid Rezaei, Somayeh Hosseinpour-Niazi, Neda Akhavan, Firoozeh Hosseini-Esfahani, Parvin Mirmiran, Fereidoun Azizi","doi":"10.1155/jnme/2102446","DOIUrl":"10.1155/jnme/2102446","url":null,"abstract":"<p><strong>Background: </strong>The present study aimed to explore the association between dietary sources of aromatic amino acids (AAAs) from both animal and plant sources and the risk of developing metabolic syndrome (MetS).</p><p><strong>Objective: </strong>The primary goal of this research was to examine how the intake of AAAs correlates with the incidence of MetS.</p><p><strong>Methods: </strong>The current prospective observational study was conducted on collected data from 4920 adult individuals aged between 19 and 74 years, participants from Tehran Lipid and Glucose Study. Dietary data and usual intake of AAAs such as phenylalanine, tyrosine, and tryptophan were calculated using a validated semiquantitative food frequency questionnaire.</p><p><strong>Result: </strong>In this study, median intakes of AAAs were 5.9 g/d (IQR: 4.7-7.4 g/d), which corresponded to 2.8 g/d (2.2-3.4 g/d) of animal sources and 2.5 g/d (1.8-3.2 g/d) of plant sources. An increased intake of total AAAs (HR: 1.28; 95% CI: 1.05, 1.57) and AAAs from animal sources (HR: 1.30 and 95% CI: 1.03, 1.65) was positively linked to a higher risk of MetS, even after controlling for confounding variables. In different strata of BMI, the risk of MetS was positively associated with MetS only in obese subjects in the highest tertile of total AAAs intake (HR: 1.36 and 95% CI: 1.02-1.87) and for AAAs from animal sources (HR: 1.16 and 95% CI: 1.09-2.12). Nevertheless, none of the three BMI groups showed a statistically significant association between incident MetS and AAAs from plant sources. Also, no significant interactions were found between sex and AAAs intake and its constituents on MetS risk.</p><p><strong>Conclusion: </strong>The intake of AAAs, particularly from animal sources, was positively associated with the risk of MetS, especially in obese individuals. However, more studies are needed in this area.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2025 ","pages":"2102446"},"PeriodicalIF":2.4,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12629699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145564398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Predictors of Obesity, Undernutrition, and Anemia in Women of Reproductive Age Living in Nepal: A Scoping Review.","authors":"Shishir Paudel, Tulsi Ram Bhandari, Yoko Oda Thapa, Amar Nagila, Anisha Chalise, Nawaraj Chapagain, Sakai Hiroko","doi":"10.1155/jnme/8897249","DOIUrl":"10.1155/jnme/8897249","url":null,"abstract":"<p><p>Malnutrition remains a critical public health issue among women of reproductive age (WRA) worldwide, and Nepal is no exception, as the country experiences a triple burden of malnutrition among WRA, including undernutrition, overnutrition, and anemia. This scoping review aimed to map and synthesize the existing literature to explore the scope of research on the prevalence and predictors of malnutrition (underweight, obesity, and anemia) among WRA in Nepal. A comprehensive search was conducted using several databases, including MEDLINE, DOAJ, CINAHL, and NepJOL, covering studies published between January 1, 2000, and June 15, 2024. Studies reporting the prevalence and/or predictors of undernutrition, obesity, or anemia among women aged 15-49 years in Nepal were included in this review. The exclusion criteria were studies focusing on disease-specific malnutrition, review articles, and clinical trials. Studies relying solely on secondary analyses of Nepal Demographic and Health Survey (NDHS) data were excluded to prevent duplication of estimates. A total of 1448 records were retrieved, and 751 duplicates were removed, leaving 697 records for screening. After excluding 577 records at the title/abstract stage, 120 full texts (including 6 from citation searching) were assessed, and 16 studies met the inclusion criteria. The prevalence of underweight ranged from 2.0% to 30.3%; overweight/obesity ranged from 4.8% to 55.0%; and anemia ranged from 12.83% to 66.8%. Definitions and measurement methods varied considerably across studies, contributing to wide variability in reported prevalence estimates. The studies identified numerous factors associated with malnutrition. Demographic and socioeconomic characteristics such as age, ethnicity, family size, educational status, occupation, food consumption patterns, and health-seeking behavior were linked to different forms of malnutrition. Anemia was associated with women's ethnicity, deworming medication, and reproductive health factors, such as menarcheal status and number of antenatal visits. This review maps the existing research on malnutrition among WRA in Nepal, identifying key trends and critical gaps that require further investigation. It also emphasizes the need for multisector-targeted interventions to address the diverse factors contributing to malnutrition, including anemia.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2025 ","pages":"8897249"},"PeriodicalIF":2.4,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12585867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145451463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interplay Between Dietary Phytochemicals and Gut Microbiota in Colorectal Cancer: Future Directions and Considerations.","authors":"Fernando Tume, Edgardo J Palma-Gutierrez, Román Acevedo-Espinola, Marysol Olivares-Etchebaster","doi":"10.1155/jnme/5512453","DOIUrl":"10.1155/jnme/5512453","url":null,"abstract":"<p><p>Colorectal cancer (CRC) is one of the most lethal cancers worldwide. Its development and progression are influenced by a combination of genetic and environmental factors such as diet. Recent studies highlight the role of dietary phytochemicals in the prevention and treatment of CRC. In this review, we explore the role of phytochemicals in directly targeting CRC and examine how microbiota convert these phytochemicals into bioactive metabolites. These metabolites may play a preventive and therapeutic role against CRC through cellular, molecular, and epigenetic mechanisms. We emphasize the need for additional actions to translate the existing knowledge effectively and safely into complementary treatments for CRC patients. The incorporation of phytochemical-rich diets represents a viable option in the battle against this debilitating condition.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2025 ","pages":"5512453"},"PeriodicalIF":2.4,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12585870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145451538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coffee Roast Level, Timing, and Carbohydrate Source Affect Peak Blood Glucose and Area Under the Curve Values in a Randomized Pilot Clinical Trial.","authors":"Lina Maria Rayo-Mendez, Craig Kinzer, Jonathan McMahon, Magaritte Nguyen, Gabriel Keith Harris","doi":"10.1155/jnme/4174563","DOIUrl":"10.1155/jnme/4174563","url":null,"abstract":"<p><p>Roasted coffee's bioactive compounds may affect human glucose metabolism. This pilot clinical trial investigated the impact of coffee roast level, coffee timing, and carbohydrate (CHO) type on blood glucose responses. Healthy participants (15 female and 4 male) completed this six-week, randomized, single-blinded study. Treatments comprised combinations of roast levels (light, medium, or dark), coffee timings (pre-, co-, or post-CHO ingestion), and CHO types: oral glucose tolerance test (OGTT) beverages or a standardized breakfast designated as PreO, PreB, CoO, CoB, PostO, and PostB. Subjects consumed 300 mL of test beverages and provided 10 capillary blood samples over 4 h. Coffees were analyzed for caffeine, 3, 4, and 5 chlorogenic acids (CGA), trigonelline, total phenols, color, °Brix, and total dissolved solids (TDS). Significant (<i>p</i> < 0.05) differences in 3CQA, 5CQA, and trigonelline, but not caffeine and 4CQA, were observed across roast levels. Prior to CHO, coffee did not increase blood glucose, but potentiated increases after CHO. PreO and PreB treatments produced the highest peak glucose values (160 mg/dL). This was not observed for co- or posttreatments. In the CoO combination, AUC values were significantly (<i>p</i> < 0.05) lower than placebo only for medium roast. In posttreatments, peak glucose levels were higher following OGTT than breakfast, but AUCs did not differ. Light roast coffee yielded the lowest AUC for PreO and the highest peak at 3 h in the CoO combination. Medium roast resulted in the lowest AUC across all time points in CoO, while both medium and dark roasts elevated AUC in PreO. Only dark roast increased AUC in the PreB condition. Three AUC main effects (CHO type, coffee roast, and timing) and two interactions (timing × roast; timing × CHO × roast) were highly significant (<i>p</i> < 0.002). These findings may benefit those desiring temporary blood glucose elevations for exercise performance and recovery versus those seeking to moderate glucose. <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT05119153.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2025 ","pages":"4174563"},"PeriodicalIF":2.4,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12575026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145431751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involvement of Phosphate and the Consequences of Its High Consumption in Energy Metabolism and Muscle Functions.","authors":"Nourin Jahan, Asadur Rahman, Akira Nishiyama, Kento Kitada","doi":"10.1155/jnme/5383415","DOIUrl":"10.1155/jnme/5383415","url":null,"abstract":"<p><p>Phosphate is an important element in energy metabolism and muscle function and is essential for numerous biological processes. This review emphasizes the implications of increased phosphate intake, particularly from processed foods supplemented with phosphate additives. These dietary habits raise substantial concerns regarding their potential health effects, including the exacerbation of metabolic disorders. Elevated phosphate levels disrupt the delicate balance between energy production and utilization, markedly influencing key metabolic processes in skeletal muscle. Excessive phosphate intake may impair mitochondrial function, reduce adenosine triphosphate synthesis, and alter phosphocreatine levels, which are vital for effective muscle contraction and endurance. Additionally, chronic high-phosphate consumption has been linked to increased inflammation and oxidative stress, contributing to cardiovascular complications and muscle atrophy, especially in susceptible populations, such as those with chronic kidney disease. This review summarizes the current understanding of phosphate metabolic functions and the detrimental effects of excessive phosphate intake on energy metabolism and muscular performance. We provide insights into the adverse health effects linked to elevated phosphate levels, particularly focusing on the consequences on muscle strength and overall muscular function. In addition, we highlight the gaps in the literature and propose future studies to understand the effects of high-phosphate diets on energy metabolism, muscle function, and structural integrity through molecular processes.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2025 ","pages":"5383415"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12507500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Concentration of Ethanol as a Vehicle for the Administration of Resveratrol Measured Through Its Antioxidant Effect in the Hippocampus of Wistar Rats.","authors":"Addí Rhode Navarro-Cruz, Ivan Cesar-Arteaga, Daniel Juárez-Serrano, Raúl Ávila-Sosa Sánchez, Teresa Soledad Cid-Pérez, Obdulia Vera-López, Gladys Quezada-Figueroa, Ashuin Kammar-García, Orietta Segura-Badilla","doi":"10.1155/jnme/6614635","DOIUrl":"10.1155/jnme/6614635","url":null,"abstract":"<p><p><b>Introduction:</b> Oxidative stress is an imbalance between endogenous antioxidants and oxidizing molecules, the latter having an unpaired electron in their last valence layer, with those derived from oxygen and nitrogen being the most important. Resveratrol is a natural polyphenol with antioxidant properties that reduce oxidative stress. However, the bioavailability of resveratrol is low due to its rapid excretion and extensive metabolism. Polyphenols improve their bioavailability in the presence of ethanol, a popular substance present in alcoholic beverages, which is used as a vehicle in the pharmaceutical industry. The objective of this work was to determine the optimal concentration of ethanol for the administration of resveratrol at a concentration of 10 mg/kg/day. Fifty-four Wistar male rats were randomly allocated to nine groups: control (water), four vehicle groups (2.5%, 5%, 7.5%, and 10% ethanol v/v), and four resveratrol + vehicle groups (10 mg/kg/day + ethanol concentrations 2.5%-10%) (ResVitále®, <i>Polygonum cuspidatum</i>, USA). Posterior to administration, the hippocampus of Wistar rats was analyzed for oxidative stress and enzyme activity. Nitric oxide levels and lipid peroxidation products were significantly lower with 7.5% ethanol, compared to 10% ethanol. Resveratrol modulated CAT and SOD activity at certain ethanol concentrations, with a limited overall effect. In conclusion, 7.5% ethanol is the most optimal vehicle concentration for enhancing the antioxidant effects of resveratrol.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2025 ","pages":"6614635"},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Gut Microbiota-Derived Short-Chain Fatty Acids With Persistent Elevated Serum Transaminase Levels in Normal Weight and Obesity: A Pilot Study.","authors":"David Alberto Díaz de Sandy-Galán, Hugo Villamil-Ramírez, Maricela Rodríguez-Cruz, Blanca López-Contreras, Paola León-Mimila, Marisol Olivares-Arévalo, Jorge Maldonado-Hernández, Israel Domínguez-Calderon, Jorge Salmerón, Daniel Cerqueda-García, Teresa Villarreal-Molina, Rafael Velázquez-Cruz, Samuel Canizales-Quinteros","doi":"10.1155/jnme/6652392","DOIUrl":"10.1155/jnme/6652392","url":null,"abstract":"<p><p>Although obesity is the most common risk factor for hepatic steatosis, this disease may occur in normal-weight individuals. While gut microbial metabolites such as short-chain fatty acids (SCFAs) have been associated with obesity and metabolic disease, the relationship among fecal SCFA concentrations, SCFA-producing bacteria, and hepatic steatosis with and without obesity is not fully understood. This pilot study aimed to compare fecal SCFA concentrations and SCFA-producing gut bacteria in four study groups: 7 individuals with normal-weight and normal alanine aminotransferase levels (Nw-N ALT), 7 individuals with normal-weight and elevated ALT levels (Nw-E ALT), 12 individuals with obesity and normal ALT levels and (Ob-N ALT), and 18 individuals with obesity and elevated ALT levels (Ob-E ALT). Fecal SCFA concentrations were quantified using gas chromatography, and gut microbiota was characterized by sequencing 16S rRNA. Median fecal SCFA concentrations (propionate, butyrate, and valerate) were highest in the Ob-E ALT group and lowest in the Nw-N ALT group (<i>p</i> < 0.05). These SCFA concentrations were also higher in obese than in normal-weight individuals regardless of ALT levels (<i>p</i> < 0.05) and in elevated ALT individuals regardless of obesity status, although the difference lost significance after correction for multiple testing. Notably, the abundance of <i>Roseburia</i> was higher in Ob-N ALT and Ob-E ALT than in the Nw-N ALT group and correlated positively with fecal SCFA concentrations. In conclusion, this pilot study suggests that the presence of both obesity and persistent elevated serum ALT levels is associated with increased fecal SCFA concentrations and SCFA-producing bacteria, particularly <i>Roseburia</i>. However, a larger sample is required to define whether the associations of SCFA fecal levels with obesity and elevated ALT levels are independent.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2025 ","pages":"6652392"},"PeriodicalIF":2.4,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Causal Evidence for the Role of Circulating Lipid Metabolites in Breast Cancer Risk: A Bidirectional Mendelian Randomization Analysis.","authors":"Cheng Zeng, Shuning Liu, Yuhan Wei, Yalong Qi, Yujing Tan, Haili Qian, Jiani Wang, Fei Ma","doi":"10.1155/jnme/2292774","DOIUrl":"10.1155/jnme/2292774","url":null,"abstract":"<p><p><b>Background:</b> Dysregulated lipid metabolism has been implicated in breast cancer pathogenesis; however, the causal nature of these associations remains unclear. This study aimed to investigate the causal relationships between circulating lipid metabolites and the risk of estrogen receptor-positive (ER+) and ER-negative (ER-) breast cancer using a bidirectional Mendelian randomization (MR) approach. <b>Methods:</b> We evaluated 386 circulating lipid metabolites as exposures in two-sample MR analyses, with ER+ and ER- breast cancer as outcomes. Genetic instruments were selected based on genome-wide significance (<i>p</i> < 1 × 10^-5) and linkage disequilibrium clumping (<i>R</i> ² < 0.01 within a 1000 kb window). The inverse variance weighted method was used as the primary analytical approach. Sensitivity analyses-including MR-Egger regression, Cochran's <i>Q</i> test, and leave-one-out analyses-were conducted to assess pleiotropy and heterogeneity. Validation analyses were performed using an independent genome-wide association study (GWAS) dataset for ER+ breast cancer. Reverse MR analysis was also conducted to evaluate potential reverse causality. <b>Results:</b> Among the 386 lipid metabolites analyzed, 24 and 23 exhibited nominal associations (<i>p</i> < 0.05) with ER+ and ER- breast cancer, respectively. After applying false discovery rate (FDR) correction (FDR < 0.05), three metabolites-myristoleate (14:1n5), tricosanoyl sphingomyelin (d18:1/23:0), and 5α-androstan-3β, 17β-diol monosulfate (2)-remained significantly associated with an increased risk of ER+ breast cancer. In contrast, none of the associations with ER- breast cancer remained significant after FDR correction. Sensitivity analyses indicated no evidence of horizontal pleiotropy or heterogeneity, and the associations remained robust in leave-one-out analyses. These findings were further validated in an independent GWAS dataset. Moreover, reverse MR analysis found no evidence supporting a causal effect of ER+ breast cancer on the levels of the three identified lipid metabolites. <b>Conclusions:</b> This study provides robust genetic evidence supporting a causal role for specific lipid metabolites in the development of ER+ breast cancer. These metabolites may serve as potential biomarkers for early detection and targets for preventive interventions.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2025 ","pages":"2292774"},"PeriodicalIF":2.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}