Journal of Nutrition and Metabolism最新文献

{"title":"Characterization of Gastrointestinal Absorption of Salmon Milt-Derived Oligodeoxyribonucleic Acids in Mice.","authors":"Fuyu Hayashi, Yusuke Masuo, Yuki Nishizawa, Ayaka Koike, Takahiro Ishimoto, Keisuke Kiriyama, Mica Fujita, Keita Sutoh, Yukio Kato","doi":"10.1155/jnme/2183675","DOIUrl":"10.1155/jnme/2183675","url":null,"abstract":"<p><p>Dietary nucleic acids exert physiological effects beyond serving as substrates for nucleic acid synthesis; however, their exact molecular forms that are absorbed in the small intestine remain unclear. In this study, we investigated the absorption forms of food-derived DNA by comprehensively quantifying 31 nucleic acid monomers that permeated the intestinal membrane after oral administration, using LC-MS/MS. Hydrolyzed <i>Oncorhynchus</i> milt DNA (HD-omDNA; mainly 1-4-mer nucleotides), deoxyribonucleotides (dNTs), and deoxyribonucleosides (dNSs) were orally administered to mice, and blood samples were collected from the tail vein, aorta, and portal vein. Intestinal permeation was also assessed using the Ussing chamber method. Oral administration of HD-omDNA, dNTs, or dNSs increased the plasma levels of pyrimidine dNSs-such as thymidine, deoxyuridine, and deoxycytidine-identifying them as the major forms of high-molecular-weight DNA absorbed into systemic circulation. Portal vein concentrations of these pyrimidine dNSs were elevated compared with vehicle controls, confirming their intestinal absorption. In contrast, purine nucleic acid monomers were metabolized to uric acid, as indicated by elevated portal vein concentrations of its precursors, hypoxanthine, and xanthine upon co-administration with the xanthine oxidase inhibitor febuxostat. Notably, dinucleotides were also detected in portal vein plasma in vivo and on the basolateral side in Ussing chamber experiments, suggesting that dinucleotides are a previously unrecognized absorption form of HD-omDNA. Collectively, these findings demonstrate that dietary DNA permeates the intestine mainly as pyrimidine dNSs, whereas dinucleotides are also an absorption form, revealing unique absorption characteristics of dietary deoxyribonucleotides and oligodeoxyribonucleotides.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"2183675"},"PeriodicalIF":4.0,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13239040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Complementary Feeding Practices and Determinants Among 6-23 Months Aged Children's Mothers in Kedida Gamela District and Durame Town, Southern Ethiopia: Cross-Sectional Comparative Study.","authors":"Yididia Desta Langena, Diliab Desta Langena, Minale Fekadie Baye, Alemayehu Atomsa Sona, Melese Sinaga Teshome","doi":"10.1155/jnme/5360358","DOIUrl":"10.1155/jnme/5360358","url":null,"abstract":"<p><strong>Background: </strong>For children to grow and develop to their full potential, the first 2 years of life are critical. Infectious disease incidence and associated mortality can be reduced by optimal complementary feeding practices. Studies on these practices and determinants, however, are few in this field. The purpose of this study is to close this information gap.</p><p><strong>Methods: </strong>Between January 15 and February 15, 2021, 565 mothers of children ages 6 to 23 months participated in a community-based comparative cross-sectional study in Durame town and Kedida Gamela district. Structured questionnaires were used to gather data through in-person interviews, and SPSS Version 25 was used for analysis. Determinants of complementary feeding practices were identified through bivariate and multivariable logistic regression, utilizing adjusted odds ratios with a 95% confidence interval <i>p</i> value 0.05.</p><p><strong>Results: </strong>Complementary feeding practice magnitudes in rural and urban areas were 13.1% and 25.1%, respectively. The mother's knowledge of good complementary feeding (AOR = 5.13, 95% CI: 1.68, 15.65) and household food insecurity (AOR = 3.5, 95% CI: 1.4, 8.75) was associated with optimal complementary feeding practices in rural areas, while child age (AOR = 3.57, 95% CI: 1.08, 11.805), postnatal care (AOR = 2.58, 95% CI: 1.28, 5.16), and the mother's awareness about complementary feeding practices (AOR = 4.5, 95% CI: 1.13, 14.17) were associated with good complementary feeding practices in urban settings.</p><p><strong>Conclusion and recommendation: </strong>In comparison with rural areas, the magnitude of optimal complementary feeding practice is significantly higher in urban areas. Integration of nutrition education and infant and young child feeding into maternal and child health services is essential to improving child feeding practices.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"5360358"},"PeriodicalIF":4.0,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13213713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148054809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Diversity and Associated Factors Among Children in the Tahtay Maichew District, Northern Ethiopia.","authors":"Ermyas Brhane Reda, Teklit Grum, Kiros Gereziher Arefayne, Ebud Ayele Dagnazgi, Teklehaymanot Huluf Abraha, Gebrekiros Aregawi, Shewit Engdashet Berhe","doi":"10.1155/jnme/2092071","DOIUrl":"10.1155/jnme/2092071","url":null,"abstract":"<p><strong>Background: </strong>Children aged 6-23 months are in a period of intense physical and neurological development and therefore require nutrient-dense complementary foods from multiple food groups. However, information on what young children eat and which factors influence the variety of their diets remains scarce in the study area. Therefore, this study was conducted to assess the level of dietary diversity among 6-23-month-old children in the Tahtay Maichew district and to identify demographic, household, and health-service-related determinants of their food variety.</p><p><strong>Methods: </strong>A community-based cross-sectional study was carried out among 981 children aged 6-23 months in the Tahtay Maichew district, northern Ethiopia. Dietary diversity was evaluated using a 24-h maternal recall of all foods and beverages consumed by the child. After checking questionnaires for completeness and consistency, data were coded and entered into EPI INFO Version 7 and then exported to STATA-12 for analysis. In the final multivariable model, variables with a <i>p</i> value < 0.05, identified through backward elimination, were considered factors associated with dietary diversity.</p><p><strong>Results: </strong>Only 31.1% (95% CI: 28.3%-34.3%) of children received the recommended minimum dietary diversity for their age. Having a housewife mother (AOR = 1.76, 95% CI = 1.15-2.7), being from a government-employed mother (AOR = 2.67, 95% CI = 1.03-6.87), having a father with primary (AOR = 1.67, 95% CI = 1.01-2.77) or secondary education (AOR = 2.12, 95% CI = 1.26-3.57), attending postnatal care follow-up (AOR = 1.54, 95% CI = 1.08-2.21), and good maternal knowledge of child feeding were significantly associated with achieving recommended dietary diversity among children.</p><p><strong>Conclusion: </strong>The proportion of children meeting the minimum dietary diversity was low. Mothers' occupation, husband's educational status, postnatal care follow-up, and maternal knowledge of child feeding were independent determinants of dietary diversity.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"2092071"},"PeriodicalIF":4.0,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147973097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Curcumin in Chronic Disease Management: Anti-Inflammatory Pathways, Antioxidant Activity, and Therapeutic Advances.","authors":"Sammra Maqsood, Farhang Hameed Awlqadr, Iffat Ullah, Muhammad Tayyab Arshad, Humaira Parveen, Sayeed Mukhtar, Emmanuel Laryea","doi":"10.1155/jnme/9985642","DOIUrl":"10.1155/jnme/9985642","url":null,"abstract":"<p><p>The medicinal properties of <i>Curcuma longa</i> L. (turmeric) have long been recognized, especially in traditional medicine, where it has been used to treat diverse ailments for thousands of years. The bioactive polyphenol responsible for the health benefits associated with <i>C. longa</i> is curcumin, which offers a variety of health advantages, particularly, anti-inflammatory properties. This review discusses the molecular mechanisms underlying the anti-inflammatory properties of curcumin, focusing on its interaction with significant inflammatory signaling pathways, modulation of the gut microbiota, and antioxidant activity. The therapeutic potential of curcumin is rooted in its ability to reduce enzymes such as COX-2 and LOX, downregulate proinflammatory cytokines, and block the NF-κB pathway. In addition to its ability to decrease oxidative stress, a primary mediator of inflammation, curcumin also functions in scavenging reactive oxygen species (ROS) and activating antioxidant defense systems. This review further highlights the clinical relevance of curcumin in chronic inflammatory conditions including rheumatoid arthritis, inflammatory bowel disease, and cardiovascular disorders. Despite its encouraging therapeutic potential, curcumin bioavailability remains a major problem, prompting advancements in drug administration methods. Further research is needed to improve its formulations, study how curcumin synergizes with other treatments, and conduct clinical studies.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"9985642"},"PeriodicalIF":4.0,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147973045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fructose Diet-Induced Liver Injury Through Oxidative Stress: A Systematic Review of Preclinical Studies.","authors":"Marissa Arifin, Wardatul Jannah, Neily Zakiyah, Anna Meiliana, Melisa Intan Barliana, Keri Lestari","doi":"10.1155/jnme/1644860","DOIUrl":"10.1155/jnme/1644860","url":null,"abstract":"<p><strong>Background: </strong>Fructose consumption has significantly increased in recent years and is associated with hepatic oxidative stress, playing a major role in metabolic diseases such as metabolic-associated fatty liver disease (MAFLD). This systematic review aimed to summarize how excessive fructose consumption causes liver injury through oxidative stress, leading to lipid accumulation in hepatic cells.</p><p><strong>Methods: </strong>PubMed, Scopus, and Web of Science databases were systematically searched (2019-2024) for preclinical studies using fructose-only diets. Criteria were applied to identify relevant studies. The primary outcome was hepatic oxidative stress, and the secondary outcomes included weight, metabolic markers, liver function, and histopathology changes. Two reviewers assessed bias risk using SYRCLE.</p><p><strong>Results: </strong>Among 517 studies screened, 26 met the inclusion criteria. Most studies had unclear bias risk due to poor reporting. Low-dose fructose intake (10%) over 8-12 weeks induced hepatic oxidative stress, indicated by elevated malondialdehyde (MDA) in 53.8% of cases, increased reactive oxygen species (ROS) in 19.2%, and reduced antioxidant defenses, including glutathione (GSH), GSH peroxidase (GSH-Px), and superoxide dismutase (SOD) in 38.5%. Four studies showed early upregulation of antioxidant responses (11.5%), suggesting initial adaptation. Prolonged fructose exposure (up to 36 weeks) caused sustained liver injury due to overwhelming defenses and increased oxidative stress. Most studies also reported metabolic disturbances, liver dysfunction, and lipid accumulation.</p><p><strong>Conclusion: </strong>This systematic review showed that excessive fructose consumption induces liver injury through oxidative stress, which then triggers subsequent processes like inflammation. Overconsumption led to uncontrolled hepatic metabolism, increasing lipid synthesis, metabolic overload, overproduction of ROS, impairment of antioxidant defenses, and histopathological changes.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"1644860"},"PeriodicalIF":4.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a Pregnancy Lifestyle Intervention Embedded Into a Home Visiting Program on Child Neurodevelopment.","authors":"Sarah S Farabi, Rosemary Bass, Amit Mathur, Cindy Schwarz, Candice Woolfolk, Richard Stein, Samuel Klein, Debra Haire-Joshu, Alison G Cahill","doi":"10.1155/jnme/5518243","DOIUrl":"10.1155/jnme/5518243","url":null,"abstract":"<p><p>Maternal obesity is associated with a higher risk of abnormal child neurodevelopment. The aim of this study was to determine the effect of a lifestyle intervention embedded into a home visiting program, Parents as Teachers (PAT), on 18-month neurodevelopment in the offspring. Pregnant women (9-15 weeks) of African American Race, 18-45 years old, first-trimester BMI 25.0-45.0 kg/m², and socioeconomically disadvantaged (e.g., Medicaid status) were randomized to standard home visiting (PAT only) or home visiting with lifestyle weight management counseling (PAT+), which began after the baseline assessment in pregnancy and continued until 12 months postpartum. Cognitive, language, and motor development at 18 months was assessed using the Bayley III Scales of Infant Development. Neurodevelopment outcomes were compared between groups and between child sex using un-paired <i>t</i>-tests and ANCOVA. 200 children (105 PAT+/95 PAT only) completed the neurodevelopmental testing at 18 months. Cognitive, language, and motor composite scores did not differ between groups. Across groups, number of PAT visits was positively correlated with scores in the cognitive and language domains. Our findings suggest that a lifestyle weight management program which decreased gestational weight gain does not affect offspring neurodevelopmental outcomes at 18 months. <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT01768793.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"5518243"},"PeriodicalIF":4.0,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception and Practices Regarding Muscle Loss Protection in Childhood Cancer Patients: A National Survey of Chinese Pediatric Oncologists in China.","authors":"Feng Tian, Yali Han, Pengli Wang, Chencheng Xu, Qianjun Wan, Kejia Yang, Dapeng Jiang","doi":"10.1155/jnme/8934452","DOIUrl":"10.1155/jnme/8934452","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate perception and practices regarding muscle loss protection (MLP) among Chinese pediatric oncologists in a nationwide survey.</p><p><strong>Methods: </strong>A nationwide online survey was conducted among pediatric oncologists using a self-designed structured questionnaire assessing predominant roles, barriers, practices, attitudes, and knowledge. Behavior and attitude were measured using a 5-point Likert scale. Barrier scores were based on classification: denial scores 3, uncertainty 2, and confirmation 1. Knowledge scores were calculated based on the number of correct responses (one point per correct answer). Binary logistic regression, ordinal logistic regression, and multiple linear regression models were applied to identify factors associated with knowledge, attitudes, behaviors, and composite scores related to MLP, and spatial analysis (Moran's I) was used to evaluate geographic clustering.</p><p><strong>Results: </strong>Among 253 respondents, physicians, surgeons, physiatrists, and nutritionists were most trusted to lead MLP. Physicians, particularly hematologists, received the most support as the predominant specialists. While the absence of relevant guidelines and consensus was a significant barrier, the primary barrier was illness severity. Although the general attitude was positive, behavior and knowledge were far from satisfactory. Doctors in centers with ML assessment resources had significantly higher practice scores. Spatial analysis indicated regional variation in scores, with localized patterns of relatively higher and lower performance across provinces.</p><p><strong>Conclusion: </strong>Chinese pediatric oncologists demonstrate positive attitudes but concerning deficiencies in MLP practices and knowledge, with notable disparities primarily associated with institutional resources and regional context. The development of evidence-based national guidelines is strongly recommended to standardize care and address these gaps.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"8934452"},"PeriodicalIF":4.0,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of Preoperative Very Low-Calorie Diets in Preparation for Metabolic and Bariatric Surgery.","authors":"Tala Abedalqader, Annabella R Strathman, Alberto Migliorini, Leonardo Garcia Cerecedo, Nour El Ghazal, Wah Yang, Adrian Dan, Manpreet S Mundi, Omar M Ghanem","doi":"10.1155/jnme/7371866","DOIUrl":"10.1155/jnme/7371866","url":null,"abstract":"<p><p>Very low-calorie diets (VLCDs) have been commonly implemented prior to metabolic and bariatric surgery (MBS) with the goal of shrinking left liver lobe size and reducing intra-abdominal mesenteric fat. Through this manuscript, we aimed to review the available literature discussing the types of VLCDs, their mode of implementation, preoperative duration, and the intraoperative and postoperative measures. A total of 103 articles was used in the generation of this review, including 3402 MBS candidates across the studies. VLCD was shown to induce significant preoperative weight loss, reduction in body fat mass, glycemic improvement, and decrease in proinflammatory makers. Liver volume reduction of 5%-23% and abdominal wall circumference reduction of 2.0-8.5 cm were noted following short regimens of VLCD, leading to improvement in perceived intraoperative difficulty. Postoperatively, metabolic improvements and reduction in perioperative complication rates were observed in some studies. In conclusion, VLCD demonstrated potential preoperative, intraoperative, and postoperative improvements in patients undergoing MBS.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"7371866"},"PeriodicalIF":4.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Safety Profile of Aspartame: A Review of Regulatory Standards and Emerging Health Concerns.","authors":"Hasan Uğur Öncel, Zehra Sökmen","doi":"10.1155/jnme/4727546","DOIUrl":"10.1155/jnme/4727546","url":null,"abstract":"<p><p>We reviewed the effects of aspartame, one of the artificial sweeteners widely used in the food industry, on human health. We evaluated the chemical structure, metabolic processes, and potential health effects of aspartame in light of scientific studies. Studies in various health areas, such as cancer risk assessment, effects on the nervous system and cardiovascular system, and its role in metabolic disorders, have led to various debates about the safety of aspartame for human health. While aspartame's low-calorie structure provides an advantage for metabolic diseases such as obesity and diabetes, its potential effects on insulin sensitivity and gut microbiota have led to different conclusions. In light of the adverse effects of the phenylalanine amino acid in the structure of aspartame on brain development, we have tried to emphasize that consumption levels should be more closely monitored in special risk groups such as phenylketonuria (PKU) patients, children, pregnant women, and the elderly. The widespread use of aspartame in the food industry has led to the view that this structure is safe when consumed as a sweetener at acceptable daily intake levels. This review seeks to answer, \"Is it a safe additive for human health when individual sensitivities and long-term effects are considered?\".</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"4727546"},"PeriodicalIF":4.0,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Probiotics in Psoriasis: An Umbrella Review.","authors":"Maulidah Ayuningtyas, Farapti Farapti, Siti Sarah Hajar","doi":"10.1155/jnme/1120062","DOIUrl":"10.1155/jnme/1120062","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis is an immune-mediated inflammatory skin condition that is chronic and causes a great deal of disease burden, especially for those affected in their most productive years. Gut microbiota, immune parameters and, in turn, psoriasis symptom improvement have recently been associated with the use of probiotics in several different studies.</p><p><strong>Objectives: </strong>This study aims to conduct an umbrella review of systematic reviews and meta-analyses of the effectiveness of probiotic supplementation as a possible adjuvant in the treatment of psoriasis.</p><p><strong>Methods: </strong>This umbrella review is listed in the PROSPERO database (registration number CRD420251130518) and was referenced according to the PRISMA 2020 guidelines. The data were obtained after a systematic search of the literature in Cochrane, Scopus and PubMed. The quality of the methodology was evaluated using the AMSTAR 2 tool; the overlap was evaluated with the corrected covered area (CCA) method.</p><p><strong>Discussions: </strong>Five systematic reviews and meta-analyses were included, covering hundreds of adult psoriasis patients. The probiotics studied consisted of both single-strain and multistrain formulations, sometimes combined with prebiotics. Probiotics are associated with significantly reduced Psoriasis Area and Severity Index (PASI) scores, increased PASI 75 response rates, lowered inflammatory biomarkers (CRP, TNFα, IL-6) and improved Dermatology Life Quality Index (DLQI). Greater effectiveness was found with multistrain probiotics, treatment duration of ≥ 12 weeks and studies conducted in Asia. Most studies reported good safety and minimal side effects. However, a high overlap among included reviews was observed (CCA = 38.64%), which should be considered when interpreting the findings and their limitations.</p><p><strong>Conclusions: </strong>Probiotics, particularly multistrain formulations, show potential as a safe and effective adjuvant therapy for reducing psoriasis severity and improving patient quality of life. Further clinical trials are needed to identify the most effective strains and optimal duration of treatment.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"1120062"},"PeriodicalIF":4.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}