Journal of Nutrition and Metabolism最新文献

{"title":"Metabolic Syndrome With Concomitant Anaemia Among Patients With Type 2 Diabetes Mellitus in the Volta Region of Ghana: A Cross-Sectional Study.","authors":"Sylvester Yao Lokpo, David Avoyi, Eric Boateng, Samuel Ametepe, Francis Abeku Ussher, Michael Appiah, Precious Kwablah Kwadzokpui, Esther Ngozi Adejumo, Christian Obirikorang, James Osei-Yeboah, Kenneth Ablordey, Abigail Ibrahim","doi":"10.1155/jnme/1310197","DOIUrl":"10.1155/jnme/1310197","url":null,"abstract":"<p><strong>Introduction: </strong>Anaemia and metabolic syndrome (MetS) worsen the pathogenesis of Type 2 diabetes mellitus (T2DM), leading to increased diabetes-related complications. This study aimed to assess the prevalence and associated factors of anaemia-MetS comorbidity in individuals with T2DM in the Ho municipality.</p><p><strong>Methods: </strong>A cross-sectional study was conducted between January and October 2022 at the Ho Municipal Hospital, targeting patients aged ≥ 20 years with T2DM who were conveniently selected from the diabetic clinic. Data on sociodemographic and clinical characteristics were collected using semistructured questionnaires. Anthropometric and blood pressure measurements were performed. Fasting blood samples were obtained to measure glucose, lipid profile and haemoglobin (Hb) levels. MetS was defined using the harmonized criteria, and anaemia was defined according to WHO gender-specific cut-offs. Logistic regression models were utilized to determine factors associated with anaemia alone and anaemia-MetS comorbidity.</p><p><strong>Results: </strong>A total of 193 participants were enrolled (61.7% female). The prevalence of MetS was 64.8% (<i>n</i> = 125), while anaemia prevalence was 23.8% (<i>n</i> = 46). Anaemia-MetS comorbidity was observed in 33 participants (17.1%). Anaemia with elevated fasting blood glucose (FBG) was the most frequent combination (23.8%). In the multivariable analysis, female sex was significantly associated with higher odds of anaemia-MetS comorbidity in the sociodemographic model (OR = 3.51; 95% CI: 1.34-10.31), but this association was attenuated after full adjustment. Current alcohol consumption was independently associated with substantially reduced odds of anaemia-MetS comorbidity in the fully adjusted models (OR = 0.10; 95% CI: 0.01-0.54).</p><p><strong>Conclusion: </strong>Anaemia-MetS comorbidity was common among patients with T2DM. Alcohol consumption was associated with lower odds of comorbidity, suggesting a potential protective effect that warrants further investigation. Female sex may confer increased risk, though this relationship is confounded by lifestyle and clinical factors.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"1310197"},"PeriodicalIF":4.0,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beneficial Outcome Pathways: A New Mechanistic Framework to Map the Health Effects of Fasting in Metabolic Dysfunction-Associated Steatotic Liver Disease.","authors":"Robin Mesnage, Verena Buchinger","doi":"10.1155/jnme/3190642","DOIUrl":"10.1155/jnme/3190642","url":null,"abstract":"<p><p>Lifestyle interventions such as fasting are difficult to evaluate using placebo-controlled randomized trials, resulting in fragmented and heterogeneous evidence. The beneficial outcome pathways (BOPs) framework can address this limitation by integrating mechanistic data to clarify the causal processes leading to beneficial health outcomes, adapted from the adverse outcome pathway concept in toxicology. To illustrate the approach, we apply the BOP framework to fasting interventions for metabolic dysfunction-associated steatotic liver disease (MASLD). The initial trigger is an acute energy deficit that activates AMP-activated protein kinase (AMPK) signalling and inhibits mTORC1. Downstream key changes include the activation of autophagy and lipophagy, the suppression of de novo lipogenesis, the enhancement of fatty acid oxidation and ketogenesis, anti-inflammatory changes, and the restoration of hepatic and systemic insulin sensitivity. Overall, this new framework helps connect laboratory findings with clinical results and provides a clearer way to understand how fasting improves MASLD.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"3190642"},"PeriodicalIF":4.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13063385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147674258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Power of Food Scale Scores and Weight Among Black/African American Individuals Consuming a Vegan or Low-Fat Omnivorous Diet in a Randomized Controlled Trial.","authors":"Alexis Bell, John A Bernhart, Yesil Kim, Enid A Keseko, Gabrielle Turner-McGrievy","doi":"10.1155/jnme/4084525","DOIUrl":"10.1155/jnme/4084525","url":null,"abstract":"<p><p>The NEW Soul study was a 2-year, 2-group randomized controlled trial intervention in South Carolina comparing the effects of a vegan (plant based) diet to those of a low-fat (< 30%) omnivorous diet among African American adults, ages 18-65 years old, and with overweight or obesity. The current study assessed changes in the Power of Food Scale (PFS) scores-a measure of hedonic hunger using three domains (food available, food tasted, and food present)-by group across the study and the relationship between changes in PFS scores and weight loss among all participants such that increases in PFS scores were associated with less weight loss. We used repeated measures models to compare changes in scores by group. We also used repeated measures models to see if changes in scores were associated with changes in weight, controlling for employment status, education, food security status, sex, and age. There were no differences in PFS scores between the vegan and low-fat omnivorous groups across time; however, both groups showed decreases in PFS domain scores over time suggesting reduced hedonic hunger among all participants. Furthermore, while score changes in the food available and food tasted domains were not associated with weight change, significant associations were observed for the food present domain and the total PFS scores (<i>p</i> < 0.05 for both). Future studies should more closely target food available, tasted, and present domains to see if changes are associated with weight loss. <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT03354377.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"4084525"},"PeriodicalIF":4.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147674180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Green Tea-Intake Timing on Glucose and Lipid Metabolism in Older Adults: An 8-Week Randomized Controlled Trial.","authors":"Saeka Fuke, Kyoko Fujihira, Masaki Takahashi","doi":"10.1155/jnme/2301278","DOIUrl":"10.1155/jnme/2301278","url":null,"abstract":"<p><p>Catechins in green tea have been reported to enhance glucose tolerance and lipid metabolism. However, the influence of chronic intake timing on these outcomes in older adults has not been fully elucidated. In this randomized controlled trial, we investigated the effects of green tea intake at different timings on glucose and lipid metabolism in older adults. Forty-five participants aged ≥ 65 years were randomly assigned to morning (<i>n</i> = 15), day (<i>n</i> = 15), or evening (<i>n</i> = 15) group. Participants consumed green tea daily for 8 weeks at specified times (0600-1100, 1100-1600, and 1600-2100 h for the morning, day, and evening groups, respectively). Glucose metabolism, lipid metabolism, and body composition were evaluated before and after the intervention. Blood glucose level, glycated hemoglobin level, body weight, and fat mass decreased with green tea intervention, while muscle mass increased across all groups (all <i>p</i> < 0.05). These findings indicate that individuals can expect similar improvements in glucose tolerance and body composition parameters from continuous green tea consumption regardless of intake timing in older adults. <b>Trial Registration:</b> University Hospital Medical Information Network (UMIN): UMIN000058708.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"2301278"},"PeriodicalIF":4.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13054514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: HO-1 Upregulation Attenuates Adipocyte Dysfunction, Obesity, and Isoprostane Levels in Mice Fed High Fructose Diets.","authors":"Journal Of Nutrition And Metabolism","doi":"10.1155/jnme/9842407","DOIUrl":"10.1155/jnme/9842407","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2014/980547.].</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"9842407"},"PeriodicalIF":4.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Feeding Patterns as a Dominant Factor in the Occurrence of Stunting in Toddlers in Ponorogo.","authors":"Kurnia Dwi Artanti, Dyah Silviananda Widhiastuti, Devina Dwi Kurnia, Arina Mufida Ersanti, Taufiq Hidayat","doi":"10.1155/jnme/7589972","DOIUrl":"10.1155/jnme/7589972","url":null,"abstract":"<p><strong>Introduction: </strong>Stunting in Indonesia, caused by nutritional deficiencies from pregnancy until the age of two, remains above the WHO target despite a decrease in prevalence from 37.2% in 2017 to 21.6% in 2022. The detrimental impact of stunting on child development and the high rates in Indonesia underscore the importance of improving maternal and child nutrition to reduce this prevalence.</p><p><strong>Objective: </strong>The objective of this study was to analyze the effect of feeding patterns on the incidence of stunting in toddlers in the Ponorogo District.</p><p><strong>Methods: </strong>This research is an analytical observational study with a case-control study design. The sample size was calculated using the case-control sample size formula with a 1:1 ratio, resulting in 44 cases and 44 control samples. The case samples consist of children aged 1-5 years who experience stunting in the North Ponorogo Community Health Center area. The control samples consist of children aged 1-5 years who do not experience stunting in the same area. The sampling method used is simple random sampling. Risk factor analysis uses the odds ratio (OR) value and a 95% confidence interval (CI).</p><p><strong>Results: </strong>There is an association between feeding patterns and the incidence of stunting, with an OR value of 14.54 (95% CI = 3.11 < OR < 67.86). There is no association between immunization completeness status and the incidence of stunting, with an OR value of 0.42 (95% CI = 0.14 < OR < 1.25).</p><p><strong>Conclusions: </strong>Based on the conducted research, it can be concluded that there is a significant relationship between feeding patterns and the incidence of stunting in the North Ponorogo Community Health Center area. Inadequate feeding patterns significantly increase the risk of stunting.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"7589972"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbiota Alterations in Hypothyroidism: A Pilot Study Revealing Increased Abundance of Specific Bacterial Genera.","authors":"Zahra Hoseini Tavassol, Farima Farsi, Fateme Ettehad-Marvasti, Hanieh-Sadat Ejtahed, Shirin Hasani-Ranjbar","doi":"10.1155/jnme/9988966","DOIUrl":"10.1155/jnme/9988966","url":null,"abstract":"<p><strong>Background: </strong>Hypothyroidism (HT) is a prevalent thyroid disorder characterized by insufficient thyroid hormone production, leading to metabolic complications. Emerging research suggests a link between gut microbiota and thyroid regulation, positing that alterations in gut bacterial populations may contribute to HT's development and progression. This study aimed to investigate these associations by comparing gut microbiota compositions between individuals with HT and healthy adults, potentially refining diagnostic tools and therapeutic strategies.</p><p><strong>Methods: </strong>In this pilot study conducted between 2019 and 2023, 15 hypothyroid patients and 15 age- and gender-matched healthy controls participated in the study. Exclusion criteria were applied to eliminate confounding factors. Anthropometric data were collected, and stool samples underwent microbial analysis. Total bacterial DNA was extracted, and quantitative real-time PCR targeting 16S rRNA genes across eight bacterial genera was performed. The Mann-Whitney <i>U</i> test was used for statistical analyses.</p><p><strong>Results: </strong>No significant differences were observed in baseline demographic and anthropometric characteristics between groups. However, hypothyroid patients exhibited significantly elevated levels of <i>Bacteroides</i>, <i>Bifidobacterium</i>, <i>Escherichia</i>, <i>Fecalibacterium</i>, and <i>Prevotella</i> (<i>p</i> values < 0.001-0.030). No significant differences were found in levels of <i>Akkermansia, Lactobacillus</i>, or in the <i>Bacteroides</i>/<i>Prevotella</i> ratio.</p><p><strong>Conclusion: </strong>This pilot study provides preliminary indications of a possible role of gut microbiota in the pathophysiology of HT. Variations in bacterial composition suggest a significant influence of gut health on thyroid regulation. Future studies with larger cohorts are needed to explore the biological pathways linking the gut microbiome to thyroid function, which may lead to novel microbiota-targeted therapeutic approaches.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"9988966"},"PeriodicalIF":4.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12946809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese Herbal Medicines for Diabetic Cardio-Cerebrovascular Diseases: Key Bioactive Metabolites and Action Mechanisms.","authors":"Ying Su, Shuwen Luo, Wei Li, Cuicui Cheng, Wei Liu, Xinyu Yang, Zhen Xing","doi":"10.1155/jnme/5563248","DOIUrl":"10.1155/jnme/5563248","url":null,"abstract":"<p><p>Currently, the global incidence of diabetes is increasing, particularly in populous developing regions. In China, over 290 million people are affected by diabetic cardio-cerebrovascular diseases. These diseases account for more than 40% of deaths and impose a significant economic burden on both society and families. Diabetes can result in vascular complications through multiple mechanisms, including cardiovascular and cerebrovascular diseases. Current management guidelines recommend conducting risk assessments before prescribing medications like antihypertensives, hypoglycemics, and lipid-lowering drugs, alongside lifestyle interventions, to help prevent cardio-cerebrovascular diseases. However, pharmacological approaches have several limitations, including adverse drug reactions and variability in patient responses. Chinese herbal medicine (CHM) exerts its therapeutic effects via bioactive metabolites that modulate multiple molecular targets, including enzymes, receptors, and transcriptional regulators, through complex interactions with cellular signaling networks. While modern pharmacological research validates its polypharmacological mechanisms, concerns persist regarding potential botanical drug interactions, toxicological profiles, and pharmacokinetic variability of certain botanicals. Only through a balanced scientific approach can CHM's unique therapeutic value be fully realized. This review evaluates the efficacy of CHM in mitigating metabolic disorders, focusing on its diverse pharmacological mechanisms, including antioxidant defenses, inflammation suppression, and programmed cell death regulation. It elucidates the role of pivotal signaling cascades, including the glucagon (GLC)/5'-adenosine monophosphate-activated protein kinase (AMPK)/nuclear transcription factor-κB (NF-κB) axis, the GLC/peroxisome proliferator-activated receptor α (PPARα)/PGC-1α pathway, as well as the PI3K/Akt and AMPK/mammalian target of rapamycin (mTOR) signaling pathway, alongside oxidative stress and inflammatory responses. However, future research should prioritize well-structured clinical trials and mechanistic studies to substantiate CHM's therapeutic potential.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"5563248"},"PeriodicalIF":4.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12930105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-Analysis of Refeeding Syndrome in Predicting the Risk of Occurrence in Critically Ill Patients.","authors":"Xuanle Wu, Min Zhang, Jiajia Pan","doi":"10.1155/jnme/6660254","DOIUrl":"10.1155/jnme/6660254","url":null,"abstract":"<p><strong>Background: </strong>Patients admitted to the intensive care unit (ICU) have a high risk of refeeding syndrome (RFS). Identifying RFS in its early stages is often challenging, making preventive interventions for high-risk patients difficult. The aim of this review is to identify risk factors for RFS in ICU patients receiving nutritional support.</p><p><strong>Study design: </strong>We systematically searched CNKI, Wanfang, VIP, PubMed, Cochrane, Embase, and Web of Science up to November 2024 for cohort/case-control studies assessing RFS risk factors in adults (≥ 18 years). Risk of bias was evaluated using Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I). Data were analyzed using RevMan 5.4.</p><p><strong>Results: </strong>Eighteen articles were included, comprising 3360 cases. Baseline serum phosphate [weighted mean difference (WMD) = -0.10, 95% confidence interval (95% CI) (-0.19∼-0.01)], magnesium [WMD = -0.01, 95% CI (-0.04-0.02)], potassium [WMD = -0.02, 95% CI (-0.06-0.02)], albumin [WMD = -2.08, 95% CI (-3.81, -0.36)], prealbumin [(WMD = -15.37, 95% CI (-33.00-2.27)], daily protein intake [WMD = 0.23, 95% CI (0.17-0.28)], APACHE II score [WMD = 2.65, 95% CI (1.22-4.08)], NRS2002 score [WMD = 0.68, 95% CI (-0.41-1.77)], SOFA score [WMD = 1.87, 95% CI (1.50-2.25)], age [WMD = 8.67, 95% CI (7.14-10.19)], daily calorie intake [odds ratio (OR) = 0.35, 95% CI (0.25, 0.49)], feeding within 48 h of ICU admission [OR = 1.98, 95% CI (1.56, 2.51)], and a history of diabetes [OR = 3.84, 95% CI (1.17, 12.59)] are the risk factors for meta-analysis in this article. The ROBINS-I assessment showed moderate-to-severe bias (10 severe, 8 moderate).</p><p><strong>Conclusion: </strong>The meta-analysis identified serum levels of phosphorus and albumin; daily protein and calorie intake; APACHE II score; SOFA score; age; initiation of feeding within 48 h of ICU admission; and a history of diabetes as significant predictors of RFS development in critically ill patients. Serum levels of magnesium, potassium, and prealbumin and the NRS2002 score were not associated with RFS in these patients.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"6660254"},"PeriodicalIF":4.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12917335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thiamine Use in Hospitalized Patients: A Clinical Review.","authors":"Rowan E Rosewarne, Nicholas Farina","doi":"10.1155/jnme/7143046","DOIUrl":"10.1155/jnme/7143046","url":null,"abstract":"<p><p>Thiamine, or vitamin B1, is a water-soluble vitamin necessary for multiple metabolic processes throughout the human body. Thiamine is primarily obtained from our diet and is found in sources such as whole grains, legumes, and pork. Short bowel syndrome, severe malnutrition, alcohol use disorder, or diuretic use can all lead to thiamine deficiency. Thiamine deficiency may contribute to significant morbidity if not promptly identified and treated. Thiamine supplementation has been established as the primary treatment for patients with Wernicke's encephalopathy. Supplementation of thiamine is also commonly provided to patients at risk for refeeding syndrome to prevent exacerbation of an underlying thiamine deficiency when nutrition is reintroduced. More recent studies have investigated thiamine supplementation for a broader use in patients with sepsis, impaired lactate clearance, and delirium. The purpose of this review is to provide an overview of the indications for thiamine supplementation in hospitalized patients, analyze literature for historical and emerging thiamine supplementation utilization, and provide a framework for supplementation based on indication.</p>","PeriodicalId":16587,"journal":{"name":"Journal of Nutrition and Metabolism","volume":"2026 ","pages":"7143046"},"PeriodicalIF":4.0,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146180709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}