Journal of neurophysiology最新文献_第4页

Locomotor CPG of mammals: the role of pacemaker and network mechanisms. 哺乳动物运动CPG：起搏器的作用及网络机制。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-27 DOI: 10.1152/jn.00208.2025

Yuri I Arshavsky

引用次数: 0

Simulations reveal that beta burst detection may inappropriately characterize the beta band. 模拟结果表明，β突发探测可能不恰当地表征了β波段。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-23 DOI: 10.1152/jn.00125.2024

Zachary D Langford, Charles R E Wilson

{"title":"Simulations reveal that beta burst detection may inappropriately characterize the beta band.","authors":"Zachary D Langford, Charles R E Wilson","doi":"10.1152/jn.00125.2024","DOIUrl":"https://doi.org/10.1152/jn.00125.2024","url":null,"abstract":"In neurophysiological research, the traditional view of beta band activity as sustained oscillations is being reinterpreted as transient bursts. Bursts are characterized by a distinct wavelet shape, high amplitude, and, most importantly, brief temporal occurrence. The primary method for their detection relies on a threshold-based analysis of spectral power, and this presents two fundamental issues. First, the threshold selection is effectively arbitrary, being influenced by both temporally proximal and distal factors in the signal. Second, the method necessarily detects temporal events, as such it is susceptible to misidentifying sustained signals as transient bursts. To address these issues, this study systematically explores burst detection through simulations, shedding light on the method's robustness across various scenarios. Although the method is effective in detecting transients in numerous cases, it can be overly sensitive, leading to spurious detections. Moreover, when applied to simulations featuring exclusively sustained events, the method frequently yields events exhibiting characteristics consistent with a transient burst interpretation. By simulating an average difference in power between experimental conditions, we illustrate how apparent burst rate differences between conditions can emerge even in the absence of actual burst rate disparities, and even in the absence of bursts. This capacity to produce misleading outcomes challenges the reinterpretation of sustained beta oscillations as transient bursts and prompts a critical reassessment of the existing literature.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms and implications of high depolarization baseline offsets in conductance-based neuronal models. 在基于电导的神经元模型中，高去极化基线偏移的机制和意义。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-19 DOI: 10.1152/jn.00617.2024

Anal Kumar, Anzal K Shahul, Upinder Singh Bhalla

引用次数: 0

Indecision under time pressure arises from suboptimal switching behaviour. 时间压力下的优柔寡断源于次优切换行为。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-17 DOI: 10.1152/jn.00563.2024

Seth R Sullivan, Rakshith Lokesh, Jan A Calalo, Truc Ngo, John H Buggeln, Adam M Roth, Christopher Peters, Isaac Kurtzer, Michael J Carter, Joshua G A Cashaback

{"title":"Indecision under time pressure arises from suboptimal switching behaviour.","authors":"Seth R Sullivan, Rakshith Lokesh, Jan A Calalo, Truc Ngo, John H Buggeln, Adam M Roth, Christopher Peters, Isaac Kurtzer, Michael J Carter, Joshua G A Cashaback","doi":"10.1152/jn.00563.2024","DOIUrl":"https://doi.org/10.1152/jn.00563.2024","url":null,"abstract":"Indecisive behaviour can be catastrophic, leading to car crashes or stock market losses. Despite fruitful efforts across several decades to understand decision-making, there has been little research on what leads to indecision. Here we examined how indecisions arise under high-pressure deadlines. In our first experiment participants attempted to select a target by either reacting to a stimulus or guessing, when acting under a high pressure time constraint. We found that participants were suboptimal, displaying a below chance win percentage due to an excessive number of indecisions. Computational modelling suggested that participants were excessively indecisive because they failed to account for a time delay and temporal uncertainty when switching from reacting to guessing, a phenomenon previously unreported in the literature. In a follow-up experiment we pro- vide direct evidence for a functionally relevant time delay and temporal uncertainty when switching from reacting to guessing. Collectively, our results indicate that participants failed to account for a time delay and temporal uncertainty associated with switching from reacting to guessing, leading to suboptimal and indecisive behaviour.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ventral Striatum is Preferentially Correlated with the Salience Network Including Regions in Dorsolateral Prefrontal Cortex. 腹侧纹状体优先与突出网络相关，包括背外侧前额皮质区域。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-16 DOI: 10.1152/jn.00477.2024

Heather L Kosakowski, Jingnan Du, Vaibhav Tripathi, Mark C Eldaief, Randy L Buckner

{"title":"Ventral Striatum is Preferentially Correlated with the Salience Network Including Regions in Dorsolateral Prefrontal Cortex.","authors":"Heather L Kosakowski, Jingnan Du, Vaibhav Tripathi, Mark C Eldaief, Randy L Buckner","doi":"10.1152/jn.00477.2024","DOIUrl":"10.1152/jn.00477.2024","url":null,"abstract":"The ventral striatum (VS) receives input from the cerebral cortex and is modulated by midbrain dopaminergic projections in support of processing reward and motivation. Here we explored the organization of cortical regions linked to the human VS using within-individual functional connectivity MRI in intensively scanned participants. In two initial participants (scanned 31 sessions each), seed regions in the VS were preferentially correlated with distributed cortical regions that are part of the Salience network. The VS seed regions recapitulated Salience network topography and replicated in each individual including anterior and posterior midline regions, anterior insula, and dorsolateral prefrontal cortex (DLPFC). The topography was distinct from adjacent striatal seed regions and from cortical networks associated with domain-flexible cognitive control. Unbiased comprehensive analyses of the full striatum confirmed that the VS is coupled to the Salience network while also revealing the established, spatially separated cognitive zones of the caudate and motor zones of the putamen. VS correlation with the Salience network including DLPFC was observed in 15 additional participants (scanned 8 or more times each) indicating it is a robust and generalizable finding. These results suggest that the VS contributes to a cortico-basal ganglia loop that is part of the Salience network and raise the possibility that the DLPFC may be an effective neuromodulatory target for neuropsychiatric disorders of reward and motivation because of its preferential coupling to the VS.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EEG Burst Dynamics as an Indicator of a Progressive Hypoxic State. 脑电图爆发动力学作为进行性缺氧状态的指标。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-15 DOI: 10.1152/jn.00430.2024

Matthew J Hall, Giuseppe Pellizzer, Daniel G McHail, Kara J Blacker, David J Francis, Nuri F Ince

{"title":"EEG Burst Dynamics as an Indicator of a Progressive Hypoxic State.","authors":"Matthew J Hall, Giuseppe Pellizzer, Daniel G McHail, Kara J Blacker, David J Francis, Nuri F Ince","doi":"10.1152/jn.00430.2024","DOIUrl":"https://doi.org/10.1152/jn.00430.2024","url":null,"abstract":"Hypoxia disrupts perceptual and cognitive processes, posing serious risks for aircraft pilots. To investigate the neural mechanisms underlying these effects, we analyzed EEG subband power and burst dynamics in 27 participants reporting symptoms and performing cognitive tasks under progressive hypoxia. We hypothesized that specific burst features reflect declining oxygen availability and correlate with physiological, task performance, and symptom measures. Measurements were obtained during two conditions: normoxia, with O2 maintained at 21%, and hypoxia, where O2 was progressively decreased in four exposures (14.3%, 11.8%, 9.7%, and 8.1% O2) of 5 minutes each after a 10-minute normoxia baseline. EEG burst features-rate, duration, and cross-channel synchrony-were evaluated across overlapping subbands (1-7 Hz, 5-15 Hz, 13-24 Hz) to identify neural signatures of hypoxic burden. Significant increases in burst features were observed in the 5-15 Hz and 13-24 Hz subbands starting at the second hypoxia exposure. In the 1-7 Hz subband, bursts emerged at the third exposure, coinciding with participant dropout. The strongest linear correlations of burst features with physiological, task performance, and symptom measures were found in the 5-15 Hz band: SpO₂ (-0.953), heart rate (0.963), task accuracy (-0.736), task completion time (0.653), and symptom rate (0.758). This study identifies novel EEG-based signatures of hypoxia, showing burst features increase with hypoxic exposure in a frequency- and time-dependent manner. These features strongly correlate with physiological decline and impaired cognitive performance. The findings may support real-time detection of hypoxia in aviation and other operational settings.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How shape information is coded by V4 cortical response of Macaque Monkey. 猕猴V4皮质反应如何编码形状信息。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-14 DOI: 10.1152/jn.00520.2024

Meilan Liu, Shanshan Chang, Meixuan Chen, Peichao Li, Anna Wang Roe, Jia Ming Hu

{"title":"How shape information is coded by V4 cortical response of Macaque Monkey.","authors":"Meilan Liu, Shanshan Chang, Meixuan Chen, Peichao Li, Anna Wang Roe, Jia Ming Hu","doi":"10.1152/jn.00520.2024","DOIUrl":"https://doi.org/10.1152/jn.00520.2024","url":null,"abstract":"Previous neural recording studies have shown that monkey V4 can process the shape information across populations of neurons. The responses recorded from each single neuron make it possible to retrieve shape information. However, these studies did not fully characterize the spatial distribution of activity in the cortex. There are multiple types of functional columns (orientation, curvature) in V4; how do these structures respond to different shapes? Here, with intrinsic optical imaging, we explored the cortical responses of V4 to contours (straight and curved) and shapes (circle and square). We found that in V4, the response of neurons to different shapes is highly dependent on the compositional features contained in the shape. A specific local network would have a higher response magnitude to its corresponding shape than other shapes. Meanwhile, the cortical response of V4 exhibits a tolerance to the shift of stimulus location. Our results suggest that two essential cortical response features in V4 are the specificity of the activated response pattern in the cortex and tolerance to the stimulus location variance. These features can help decode shape information from imaging results.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic inflammatory pain and chronic THC vapor inhalation alter midbrain neuronal activity. 慢性炎症性疼痛和慢性四氢大麻酚蒸气吸入改变中脑神经元活动。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-14 DOI: 10.1152/jn.00456.2024

Leslie K Kelley, Nicholas W Gilpin, Jason W Middleton

{"title":"Chronic inflammatory pain and chronic THC vapor inhalation alter midbrain neuronal activity.","authors":"Leslie K Kelley, Nicholas W Gilpin, Jason W Middleton","doi":"10.1152/jn.00456.2024","DOIUrl":"https://doi.org/10.1152/jn.00456.2024","url":null,"abstract":"In an effort to reduce reliance on opioids for the treatment of pain in the clinic, ongoing work is testing the utility of cannabinoid drugs as a potential alternative for treatment of chronic pain. We tested chronic THC vapor inhalation effects on intrinsic and synaptic properties of vlPAG neurons in male and female rats treated with Complete Freund's Adjuvant (CFA). We report that chronic THC vapor inhalation modulates intrinsic and synaptic properties of vlPAG neurons, including reductions in action potential firing rate and spontaneous inhibitory synaptic transmission in males, and that these effects occur specifically in neurons that respond to current input with a \"delayed\" firing phenotype. Treatment with CFA led to increased firing rate and increased sIPSC amplitude in vlPAG neurons of female rats, and chronic THC vapor rescued sIPSC amplitudes to control levels - these effects in females were specific to vlPAG neurons categorized as having an \"onset\" firing phenotype. Ongoing work is exploring sex-specific mechanisms and cell types involved in THC vapor inhalation effects on vlPAG neurons in rats treated with CFA, and determining the role of these changes in THC vapor inhalation effects on pain-related behavior.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iota oscillations (25-35 Hz) during wake and REM sleep in children and young adults. 儿童和年轻人在清醒和快速眼动睡眠期间的Iota振荡（25-35 Hz）。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-13 DOI: 10.1152/jn.00081.2025

Sophia Snipes

引用次数: 0

Single-shot detection of microscale tactile features. 微尺度触觉特征的单镜头检测。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-13 DOI: 10.1152/jn.00414.2024

Sasha Reschechtko, Wylianne R Pangan, Reza Zeinal Zadeh, J Andrew Pruszynski

{"title":"Single-shot detection of microscale tactile features.","authors":"Sasha Reschechtko, Wylianne R Pangan, Reza Zeinal Zadeh, J Andrew Pruszynski","doi":"10.1152/jn.00414.2024","DOIUrl":"https://doi.org/10.1152/jn.00414.2024","url":null,"abstract":"Tactile detection of very small features requires relative motion between the fingertip and a surface. The specific movement strategies that people use may be critical to maximize detection ability but little is known about the movement strategies people employ to support such detection. Here, human participants actively scanned a fingertip across a pair of silica wafers to detect which of the two contained a microscale feature (2, 6, and 10 μm height and 525 μm diameter). We constrained fingertip movement to ensure that participants would always contact the feature and would only contact the feature once. These procedures encouraged participants to use strategies that optimized detection rather than search and thus allowed us to more directly link movement strategies to detection. We also investigated the effects of fingertip movement direction and the finger used on detection. We found that participants were able to consistently detect microscale features as small as 2 μm on the basis of a single contact event. The contact forces that participants used were substantially higher than those observed in previous studies focused on tactile search or geometric feature extraction. Scanning speeds were slower than those found during tactile search but faster than those reported during geometric feature extraction. Taken in conjunction with the associations between detection and finger used as well as scan direction, our results suggest that control and consistency of fingertip movement may be a primary consideration for movement strategies that optimize tactile detection.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0