Journal of neurophysiology最新文献

{"title":"Feeding State-Specific Hormonal Tuning of Neural Circuit Modulation.","authors":"Logan J Fickling, Aaron P Cook, Wenxin Wu, Angel Erbey Ibarra, Lingjun Li, Michael P Nusbaum","doi":"10.1152/jn.00164.2025","DOIUrl":"https://doi.org/10.1152/jn.00164.2025","url":null,"abstract":"<p><p>Studies of hormone influences on neural circuits and behavior have primarily focused on the manipulation of individual hormones. Here we examine the influence of behavioral (feeding) state-specific hormonal environments on the gastric mill (chewing) circuit configured by the neuropeptide Gly¹-SIFamide (G-SIFamide) in the isolated <i>Cancer borealis</i> stomatogastric ganglion. The G-SIFamide-activated gastric mill rhythm, which is similar to that driven by the G-SIFamidergic projection neuron MCN5, is distinguished from other gastric mill rhythms by the presence of rhythmic, prolonged IC neuron bursts and associated interruptions of the pyloric rhythm. Applying 1 μM G-SIFamide in saline only occasionally activated the gastric mill rhythm, whereas this rhythm occurred more frequently when 1 μM G-SIFamide was applied in hemolymph from an unfed crab and even more often in 1 hr post-fed hemolymph. No novel gastric mill neuron activity occurred under these latter conditions, suggesting that hemolymph strengthened the G-SIFamide actions. Supporting this suggestion, 10 μM G-SIFamide in saline elicited this rhythm as frequently as 1 μM G-SIFamide in unfed hemolymph. Moreover, any G-SIFamide application following an initial application of 1 μM G-SIFamide in hemolymph (unfed or fed) or 10 μM G-SIFamide in saline, but not 1 μM G-SIFamide in saline, activated the gastric mill rhythm less frequently. Mass spectrometry analysis indicated that the hemolymph influence was unlikely due to additional G-SIFamide, because no SIFamide peptide family members were identified in either hemolymph. These results suggest that one or more non-SIFamide hormones strengthen this neuropeptide-modulated circuit output by increasing the effectiveness of the applied G-SIFamide.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the degree of post-activation depression similar between soleus responses evoked by transcutaneous spinal cord and peripheral nerve stimulation?","authors":"Julia Sordet, Alain Martin, Thomas Lapole, Ioannis G Amiridis, Jean-Pierre Quenot, Maria Papaiordanidou","doi":"10.1152/jn.00137.2025","DOIUrl":"https://doi.org/10.1152/jn.00137.2025","url":null,"abstract":"<p><p>Transcutaneous spinal cord stimulation (tSCS) evokes responses in multiple lower limb muscles, referred to as transspinal evoked potentials (TEPs). In certain conditions, these responses can result primarily from the activation of Ia afferents at the dorsal roots of the spinal cord and share similarities with the H-reflex elicited by peripheral nerve stimulation (PNS). The aim of this study was to compare these two responses with regard to the post activation depression mechanism. Volunteers participated in two experimental sessions, in which tSCS was applied at the L1-L2 level (<i>n</i> = 20, main experiment) or at the T10-T11 level (<i>n</i> = 10, additional experiment). Recruitment curves in 1s paired-pulse stimulations were constructed for the two types of stimulation. The amplitude of soleus H-reflex and TEP was matched (∼ 85 % of maximal H-reflex) and post-activation depression was tested by conditioning the H-reflex (H_COND) or the TEP (TEP_COND) using either PNS (H_TEST) or tSCS (TEP_TEST). The results of the main experiment demonstrated no significant difference in the conditioning ratios (<i>P</i> = 0.99). However, in the additional experiment the degree of post activation depression was found to be higher when a TEP was conditioned using tSCS compared to the other conditioning ratios obtained in the two experiments (for all, <i>P</i> < 0.03). Although both responses evoked on soleus muscle seem to be similarly sensitive to the post activation depression phenomenon when low stimulation intensities are used, the electrode placement seems to exert an influence on the degree of depression induced on tSCS-evoked responses.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-methyl d-aspartate receptor hypofunction reduces steady state visual evoked potentials.","authors":"Alexander Schielke, Bart Krekelberg","doi":"10.1152/jn.00296.2024","DOIUrl":"https://doi.org/10.1152/jn.00296.2024","url":null,"abstract":"<p><p>The dynamic coordination of neural activity across populations of neurons is impaired in neuropsychiatric disorders. Here, we focused on the large-scale rhythmic responses induced by flickering light. These so-called steady-state visual evoked potentials (SSVEPs) are reduced in people with schizophrenia (Sz). A large body of work has identified hypofunction of the N-methyl d-aspartate receptor (NMDAR) as a potential contributor to the symptoms of Sz. Here, we tested the hypothesis that NMDAR hypofunction can account for a reduced ability to generate the coordinated activity reflected in SSVEPs. We recorded SSVEPs using multielectrode arrays permanently implanted in the primary visual cortex of nonhuman primates. In separate sessions, animals were injected with saline (control) or a subanesthetic dose of ketamine (an NMDAR antagonist) to induce a NMDAR hypofunction state. SSVEPs generated during NMDAR hypofunction were substantially reduced and, consistent with findings in Sz, this reduction was found across a range of frequencies from 5 to 40 Hz. These findings provide novel insight into the role of NMDAR hypofunction in the generation of altered coordinated activity and provide experimental support for the hypothesis that NMDAR hypofunction underlies some of the symptoms of schizophrenia.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corticospinal excitability during timed interception depends on the speed of the moving target.","authors":"Justin R McCurdy, Daniel Zlatopolsky, Ria Doshi, Jing Xu, Deborah A Barany","doi":"10.1152/jn.00153.2025","DOIUrl":"https://doi.org/10.1152/jn.00153.2025","url":null,"abstract":"<p><p>Successfully intercepting a moving object requires precisely timing the optimal moment to act by integrating information about the target's visual motion properties. Neurophysiological evidence indicates that activity in the primary motor cortex (M1) during interception preparation is sensitive to both the target's kinematic features and motor planning. However, how visual motion signals modulate M1 during timed interception remains unclear. In the present study, we applied single-pulse transcranial magnetic stimulation (TMS) over M1 to examine how a target's kinematics influence corticospinal excitability during interception preparation. Participants were instructed to abduct their right index finger to intercept a target moving horizontally at a constant speed toward a fixed interception zone. Target speed (Fast or Slow) and travel distance (Far or Close) were manipulated while controlling motion duration across conditions. Motor-evoked potentials (MEPs) were elicited at five latencies before target arrival at the interception zone. Consistent with previous behavioral findings, movement initiation occurred earlier for faster targets and was delayed when TMS was applied closer to the target's arrival. Though MEPs were generally suppressed relative to baseline at earlier timepoints and facilitated closer to movement initiation, we observed that target speed-but not distance-influenced the time course of MEP modulation. When adjusting for movement initiation times, there was an overall reduced suppression and increased facilitation for faster-moving targets, possibly reflecting a heightened urgency to move. These results suggest M1 activity during interception preparation reflects internal estimates of target motion, which may serve to optimize interception timing and performance.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing- and Frequency-Specific Effects of Dentate Nucleus Deep Brain Stimulation on Somatosensory Evoked Potentials in People with Post-Stroke Hemiparesis.","authors":"Noah Slobodin, Owen Denes Anderson, Prateek Dullur, David Escobar Sanabria, Nymisha Mandava, Anish Singh, Carmen Toth, Andre G Machado, Kenneth B Baker","doi":"10.1152/jn.00256.2025","DOIUrl":"https://doi.org/10.1152/jn.00256.2025","url":null,"abstract":"<p><p>Deep brain stimulation (DBS) of the dentate nucleus (DN) is being investigated as a therapy to enhance perilesional cortical excitability and promote motor recovery for individuals with chronic, post-stroke motor deficits. Given that acute motor changes are not anticipated, DBS optimization would benefit from surrogate markers of stimulation's effect on cortical excitability. Here, we evaluate whether continuous and paired DN stimulation modulates somatosensory evoked potentials (SSEPs), providing first-in-human insight into their candidacy as a tool for device programming. SSEPs were collected from participants in a phase I DN DBS clinical trial to characterize the effects of continuous and paired stimulation on SSEP response characteristics. Continuous low frequency DBS did not yield significant changes in short latency peak-to-peak amplitude, though high frequency stimulation yielded significantly lower peak-to-peak amplitude during double, but not single, pulse SSEP (64% of baseline, p < 0.05). As interstimulus interval (ISI) between SSEP and DBS was increased, short-latency power decreased (p < 0.005), with greatest power at an ISI of 0 ms (156% of baseline, p < 0.05). Our results support involvement of DN output in both early and late SSEP components. Modulation was modest and variable across subjects, limiting its potential role in therapeutic programming. Further work is required to elucidate the effects of lesion size and DBS lead placement.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impairment of the blood brain barrier accelerates a negative ultraslow potential in the locust CNS.","authors":"R Meldrum Robertson, Andrew Donini, Yuyang Wang","doi":"10.1152/jn.00191.2025","DOIUrl":"https://doi.org/10.1152/jn.00191.2025","url":null,"abstract":"<p><p>Insects provide useful models for investigating evolutionarily conserved mechanisms underlying electrical events associated with brain injury and death. Spreading depolarizations (SD) are transient events that propagate through neuropil whereas the negative ultraslow potential (NUP) is sustained and reflects accumulating damage in the tissue. We used the locust, <i>Locusta migratoria</i>, to investigate ion homeostasis at the blood brain barrier (BBB) during SD and NUP induced by treatment with the Na⁺/K⁺-ATPase inhibitor, ouabain. We found that sustained SD caused by the metabolic inhibitor, sodium azide, was associated with a large reduction of K⁺ efflux through the BBB at ganglia (= grey matter) but not at connectives (= white matter). This was accompanied by a large increase in tissue resistivity but no conductance changes of identified motoneuron dendrites in the neuropil. Males recovered more slowly from ouabain-induced SD, as previously described for anoxic SD. Impairment of barrier functions of the BBB pharmacologically with cyclosporin A or DIDS, or by cutting nerve roots, accelerated the NUP, thus promoting earlier and more frequent SD, but had no effect on the temporal parameters of SD. We conclude that the mechanisms underlying onset and recovery of SD are minimally affected by the damage associated with the NUP. We suggest that future research using tissue-specific genetic approaches in <i>Drosophila</i> to target identified molecular structures of the BBB are likely to be fruitful.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of sustained cognitive loading on finger circulatory and thermoperceptual responsiveness to localized cooling.","authors":"Maaike I Moes, Antonis Elia, Ola Eiken, Michail E Keramidas","doi":"10.1152/jn.00090.2025","DOIUrl":"https://doi.org/10.1152/jn.00090.2025","url":null,"abstract":"<p><p>We examined whether finger vasomotor and thermoperceptual responses to local cooling would be modulated by sustained cognitive loading. Finger temperature, circulatory (i.e., cutaneous vascular conductance, CVC) and perceptual responses were monitored, in twelve healthy men, during and after a 30-min hand-immersion in 8°C-water, performed either immediately after a 60-min continual execution of a cognitive task (cognitive→cold trial), or during the simultaneous performance of the cognitive task (cognitive+cold trial). Subjects' responses were compared with those obtained in a control cold-provocation trial, wherein they watched an emotionally-neutral documentary. The cognitive task temporarily enhanced the perceived levels of mental effort and fatigue in both intervention trials. During cooling in the cognitive→cold trial, the area under the curve (AUC) for finger CVC was enhanced [49(23) PU･mmHg^-1･min vs. control: 36(22) PU･mmHg^-1･min], the cold-induced increase in mean arterial pressure was blunted [2(4) mmHg vs. control: 8(4) mmHg] (<i>P</i><0.01), and the thermal discomfort was alleviated [2.2(0.5) vs. control: 2.5(0.7); <i>P</i>=0.05]. In the cognitive+cold trial, no intertrial differences were noted during the cold-water immersion (<i>P</i>≥0.28), but AUC for finger CVC was augmented during the last part of the rewarming [29(12) PU･mmHg^-1･min vs. control: 24(11) PU･mmHg^-1･min; <i>P</i>=0.05]. Present findings demonstrate that <i>(i)</i> in moderately mentally-fatigued individuals, finger cold-induced vasoconstriction is transiently attenuated, and thermal discomfort is mitigated, and <i>(ii)</i> superimposition of cognitive loading on cold stress does not alter finger vasoreactivity or thermosensitivity during cooling, but facilitates reperfusion following cooling.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review of HCN channel expression and I_h in the auditory system: Then, now, and future perspectives.","authors":"George Ordiway, Kristine McLellan, Jason Tait Sanchez","doi":"10.1152/jn.00602.2024","DOIUrl":"https://doi.org/10.1152/jn.00602.2024","url":null,"abstract":"<p><p>The hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channel is highly specialized, mediating the flow of potassium and sodium ions when a cell is hyperpolarized. Since it was discovered nearly half a century ago, the HCN channel structure and function have been extensively characterized throughout the nervous system. This includes the auditory system, where HCN channels are abundantly expressed and are utilized to encode sound features with high temporal fidelity. Despite the ubiquitous presence of HCN channels in auditory regions, the physiological benefits of these channels within the auditory system have not been synthesized. Here, we summarize the reported empirical measurements of HCN channel expression and HCN channel-mediated current, known as I_h. From the hair cells of the inner ear to the auditory cortex, this comprehensive review reveals HCN channel contributions that mediate sound encoding (Graphical Abstract). First, HCN channel subtype expression is heterogeneous and varies along the auditory structures' frequency axis (i.e., tonotopic gradient). Second, I_h contributes to action potential firing patterns and is influenced by channel localization, metabolic rate, and cyclic nucleotides in a context-dependent manner. Finally, HCN channels promote behaviors related to auditory perception, including synaptic coincidence detection, a property critical for auditory temporal processing, sound localization, and binaural hearing. This review establishes key features of HCN channels and I_h, highlighting seminal work, emerging trends, and gaps in knowledge for future research.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Studies in Neuroscience: Movement-Related Cortical Stimulation to Enhance Corticospinal Transmission in Chronic Incomplete Spinal Cord Injury.","authors":"David A Cunningham, Christina V Oleson, P Hunter Peckham, Kevin Lloyd Kilgore","doi":"10.1152/jn.00083.2025","DOIUrl":"https://doi.org/10.1152/jn.00083.2025","url":null,"abstract":"<p><p>Incomplete spinal cord injury (iSCI) disrupts signal transmission at the level of injury (LOI) and in higher brain structures, weakening intracortical circuits and impairing movement initiation. A potential approach to target intracortical circuits is to deliver transcranial magnetic stimulation (TMS) during motor intention, known as movement-related cortical stimulation (MRCS). We hypothesize that delivering TMS during motor intention will enhance corticospinal excitability (CE) and improve muscle activation below the LOI. One participant with chronic severe iSCI participated in a crossover study followed by five consecutive treatment sessions. First, we investigated the impact of TMS intensity (subthreshold vs. suprathreshold) on CE when delivered 50 ms prior to movement. The participant then received five consecutive days of MRCS with active subthreshold TMS for 15-20 minutes. <i>Experiment 1:</i> CE was assessed before and after sham, suprathreshold, and subthreshold MRCS (one-week washout), targeting the abductor hallucis muscle. <i>Experiment 2:</i> CE and volitional motor unit recruitment were measured at baseline, the start of each session and 3- and 7-day follow-up. Corticomotor maps were assessed at baseline and post 3- and 7-day follow-up. Subthreshold MRCS increased CE compared to sham and suprathreshold MRCS. Five days of subthreshold MRCS increased CE, motor maps, and volitional motor unit recruitment, with improvements lasting up to 3-days follow-up and remaining above baseline at day seven. These findings suggest that timed cortical stimulation with movement intention may enhance signal transmission in iSCI below the LOI. Future studies will investigate whether MRCS can prime intracortical circuitry prior to therapy to improve motor function.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-stomatology: Neologism or a paradigm change? A perspective evaluation.","authors":"Rodrigo Valério, Israel Junior Borges do Nascimento, Patricia Valério","doi":"10.1152/jn.00149.2025","DOIUrl":"https://doi.org/10.1152/jn.00149.2025","url":null,"abstract":"<p><p><b>Background:</b> The stomatognathic system (SS) has gained higher visibility over the last decades due emerging primary records evaluating its complex relationships with the central nervous system (CNS). Multiple anatomical and functional functions can be correlated with the SS, including its critical role in craniofacial development, sensory perception, and motor coordination. Despite its central role in neurosensory integration, its relationship with the central nervous system (CNS) remains underexplored in the neurological sciences. <b>Objective:</b> The present study aimed to revisit the major (but commonly unexplored) principles of Jaw Functional Orthopedics (JFO) and evidence emerging academic foundation that supports the reframing of the SS within a generalized taxonomy of neural regulation and plasticity. We assessed whether the suggested terminology \"neuro-stomatology\" adequately reflects true conceptual scientific advancements or should be considered as a mere neologism. <b>Methods:</b> This study utilized principles of integrative synthesis of the literature, including evidence from multiple fields and medical specialties. Therefore, we collated information related to embryology, neural crest migration, cranial nerve distribution, neurotrophins signaling, as well as bone mechanotransduction, and CNS-SS feedback loops. Additionally, we emphasized our analysis and descriptive summarization on experimental and clinical results correlating mastication, neuroplasticity, and hippocampal function. <b>Results:</b> The SS is derived from neural crest cells, is formed by a dense network of afferent and efferent neural pathways and connections, exhibiting a highly developed proprioceptive sensitivity property. The functional stimulation of the SS, specially related to the mastication activation, has been demonstrated to impact hippocampal activity, besides modulating neurotrophins expression, and shaping bone architecture through cellular signaling networks. The collated evidence highlights the SS as an active modulator of the neural development, maintenance, and adaptation. <b>Conclusion:</b> Based on the various publications beforementioned, the authors conclude that the term \"neuro-stomatology\" is not solely a neologism but depicts an existing paradigm shift in comprehending of stomatognathic system physiology. This expanded evaluation of literature and historical features related to the theme reinforces the fundamentals of JFO.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}